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This study aimed to examine the prevalence of health outcomes and its associations with adverse childhood experiences (ACEs) in patients with depression. A total of 562 inpatients with depression who met the inclusion criteria were consecutively screened. All enrolled patients completed a series of assessments, including demographic information, ACEs, height and weight used to calculate body mass index (BMI), smoking, and binge drinking. The prevalence of overweight, obese, smoking and binge drinking in the whole sample was 24.3%, 3.1%, 15.7% and 23.7%, respectively. Overweight/obese were associated with physical abuse (OR = 2.793, 95%CI = 1.620-4.815, P < 0.001), emotional abuse (OR = 3.073, 95%CI = 1.796-5.259, P < 0.001; obese-OR = 11.587, 95%CI = 2.729-49.196, P = 0.001), emotional neglect (OR = 4.021, 95%CI = 2.313-6.992, P < 0.001), caregiver divorce/family separation (OR = 2.676, 95%CI = 1.626-4.404, P < 0.001; obese-OR = 5.100, 95%CI = 1.680-15.479, P = 0.004) and caregiver treated violently (OR = 2.304, 95%CI = 1.383-3.837, P = 0.001). Smoking were associated with physical abuse (OR = 2.756, 95%CI = 1.432-5.304, P = 0.002), emotional abuse (OR = 2.811, 95%CI = 1.499-5.270, P = 0.001), physical neglect (OR = 2.901, 95%CI = 1.504-5.596, P = 0.001), sexual abuse (OR = 2.389, 95%CI = 1.310-4.357, P = 0.005) and caregiver incarceration (OR = 2.798, 95%CI = 1.151-6.756, P = 0.023). While physical abuse (OR = 3.164, 95%CI = 1.835-5.454, P < 0.001), emotional abuse (OR = 2.625, 95%CI = 1.529-4.508, P < 0.001), emotional neglect (OR = 2.195, 95%CI = 1.287-3.743, P = 0.004), sexual abuse (OR = 2.453, 95%CI = 1.406-4.280, P = 0.002), caregiver mental illness (OR = 2.004, 95%CI = 1.186-3.386, P = 0.009) and caregiver divorce/family separation (OR = 2.411, 95%CI = 1.481-3.926, P < 0.001)-emerged as significant correlates of binge drinking. And patients who exposed to more types of ACEs showed a higher odds of overweight/obese, smoking and binge drinking compared with patients who have not been exposed to any type ACE. The associations between ACEs and health outcomes should not only consider its potential physiological mechanism, but also consider the emotional characteristics of patients with depression, social and family factors. Besides, standardized screening of ACEs in line with Chinese culture, intervention programs to improve family environment, collaborative and traumatic information services throughout the life cycle may reduce the negative impact of ACEs on patients with depression, and then reduce the risk of health outcomes., Author(s): Lu Wang [sup.1] , Hai-Ou Zou [sup.2] , Jun Liu [sup.3] , Jing-Fang Hong [sup.1] Author Affiliations: (1) https://ror.org/03xb04968, grid.186775.a, 0000 0000 9490 772X, School of Nursing, Anhui Medical [...]

Byline: Jing-Fang. Hong, Xue-Hua. Ding, Shou-Sen. Wang Ectopic pituitary adenoma with an empty sella is extremely rare. We report an unusual patient with an ectopic growth hormone-secreting pituitary adenoma in [...]

Objective: To investigate the protein expression of Discoidin Domain Receptor 1(DDR1) in pituitary adenomas and its clinical significances. Methods: The tissue specimens and clinical data of 81 cases of pituitary adenomas and 5 cases of normal pituitary tissues were obtained. Immunohistochemistry was used to detect and compare the expression of DDR1. The correlation of DDR1 protein expression with the clinical and pathological characteristics of pituitary adenomas patients was analyzed. Results: The positive expression rate of DDR1 protein in pituitary adenomas was 64.2%(52/81). The positive expression rate of DDR1 protein in invasive pituitary adenomas was significantly higher than that in the noninvasive pituitary adenomas(x²= 16.40, P=0.000). The positive expression rate of DDR1 protein in functional pituitary adenomas was significantly higher than that in nonfunctional pituitary adenomas(x²= 18.06, P=0.000). The positive expression rate of DDR1 protein in pituitary adenomas with diameter larger than 10mm was significantly higher than that with diameter smaller than 10 mm (x²=11.68, P=0.003). Conclusion: The expression of DDR1 was significantly correlated with the invasiveness, endocrine subtypes and diameter of pituitary adenomas, DDR1 could play an important role in the pathogenesis of pituitary adenomas. [ABSTRACT FROM AUTHOR]

Background:  The treatment of paraclinoid aneurysms can be challenging due to their relationship to the cavernous sinus, carotid siphon, and optic nerve. The goal of this retrospective analysis is to compare the efficacy and safety of microsurgical versus endovascular treatments for ruptured paraclinoid aneurysms., Methods:  Medical records were reviewed to collect information about patient demographics, risk factors, diagnosis (the position and size of aneurysms), Hunt and Hess grade, and surgical method and outcomes, including modified Rankin Scale (mRS) at the time of discharge and 6 months later, complications, and death., Results:  In total, 15 and 6 patients were recruited into the microsurgery and endovascular groups, respectively. No difference was detected regarding age, sex, risk factors, and Hunt and Hess grade. Most patients had ophthalmic segment aneurysms (87% versus 83%; p  = 1.000) and small aneurysms (< 10 mm, 67% versus 100%; p  = 0.102). In the microsurgical group, five patients (33%) had large aneurysms (10-25 mm); three patients (20%) had multiple aneurysms (all p  > 0.05 compared with the endovascular group). The occlusion rate at 6 months was 93% in the microsurgical group and 100% in the endovascular group ( p  > 0.05). No difference was found regarding mRS or the complication and mortality rates between the two groups (all p  > 0.05). The occurrence of complications was not related to the location and size of aneurysms (all p  > 0.05)., Conclusions:  Our retrospective analysis indicates that good clinical outcomes can be achieved with both microsurgical and endovascular approaches. But further prospective randomized multicenter studies are needed to provide more evidence for clinical practice., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (Georg Thieme Verlag KG Stuttgart · New York.)

MicroRNAs (miRNAs) are a class of small non-coding RNAs that play key roles in cancer development and progression. Therefore, the discovery of miRNAs may provide a new and powerful tool for understanding the mechanism of carcinogenesis. In the present study, we aimed to investigate the functional significance of miR-630 and to identify its possible target genes in human non-small cell lung cancer (NSCLC). Our results showed that miR-630 was significantly down-regulated in NSCLC tissues and cell lines. The enforced expression of miR-630 was able to inhibit cell proliferation, migration, and invasion of NSCLC cells. Moreover, our results further revealed that LMO3, a nuclear LIM-only proteins, was identified as a target of miR-630. Restoration of LMO3 remarkably reversed the tumor-suppressive effects of miR-630 on cell proliferation, migration, and invasion in NSCLC cells. Therefore, we demonstrated that miR-630 suppressed the proliferation, migration, and invasion of NSCLC cells by down-regulating LMO3 expression, suggesting miR-630 as a potential therapeutic target for the treatment of human NSCLC in the future.