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17 results on '"Hong, Gregory K."'

2. Prognostic Significance of Crooke Cell Pituitary Neuroendocrine Tumor/Adenoma Subtype Status in Time to Recurrence of Corticotroph Tumors.

Author

Maragkos, Georgios A., Young, Lena, Popolizio, Vince L., Runge, Sean, Fuentes, Angelica, Mantziaris, Georgios, Catalino, Michael P., Hong, Gregory K., Vance, Mary-Lee, Lopes, Beatriz, and Jane, John

Subjects
PITUITARY tumors, NEUROENDOCRINE tumors, NEUROENDOCRINE cells, DISEASE relapse, ADENOMA
Abstract

This article examines the prognostic significance of Crooke cell adenomas (CCA), a rare subtype of corticotroph pituitary neuroendocrine tumor (PitNET)/adenoma. The study compares CCAs to non-CCA corticotroph PitNET/adenomas in terms of time-to-recurrence (TTR). The results show that while CCAs are associated with larger tumors and cavernous sinus invasion, they do not demonstrate a higher likelihood of recurrence when controlling for other known prognostic factors. The study suggests further investigation into whether CCAs have higher recurrence rates due to their aggressive phenotype or their propensity to invade the cavernous sinus. [Extracted from the article]

Published
2024
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4. Effects of Neuroanatomic Structural Distances on Pituitary Function After Stereotactic Radiosurgery: A Multicenter Study

Author

Ironside, Natasha, primary, Chen, Ching-Jen, additional, Xu, Zhiyuan, additional, Schlesinger, David, additional, Lee Vance, Mary, additional, Hong, Gregory K., additional, Jane, John A., additional, Patel, Samir, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Liscak, Roman, additional, Chytka, Thomas, additional, Jezkova, Jana, additional, Saifi, Omran, additional, Trifiletti, Daniel M., additional, Berger, Assaf, additional, Alzate, Juan, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Lazo, Erwin, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Zacharia, Brad E., additional, Mau, Christine, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, Mathieu, David, additional, Maillet, Michel, additional, and Sheehan, Jason P., additional

Published
2023
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16. The C-Mer Gene Is Induced by Epstein-Barr Virus Immediate-Early Protein BRLF1.

Author

Yuling Li, Mahajan, Nupam P., Webster-Cyriaque, Jennifer, Bhende, Prasanna, Hong, Gregory K., Earp, H. Shelton, and Kenney, Shannon

Subjects
*EPSTEIN-Barr virus, *ONCOGENIC DNA viruses, *VIRAL genetics, *VIROLOGY, *MICROBIOLOGY, *MICROORGANISMS
Abstract

BRLF1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent to the lytic form of viral replication. In this report, we show that R induces expression of the cellular C-mer gene in a variety of cell lines. C-mer expression was detected in lymphoblastoid cells immortalized with wild-type EBV but not in lymphoblastoid cells immortalized with an EBV that had BRLF1 deleted. Oral hairy leukoplakia tongue tissue, which contains the lytic form of EBV replication, also has enhanced C-mer expression. C-mer is a receptor tyrosine kinase activated by the ligand Gas6. C-mer is required for phagocytosis of apoptotic debris by monocytes/macrophages and retinal pigment epithelial cells and is capable of producing an antiapoptotic signal. Modulation of the C-mer signal transduction cascade by a variety of different approaches did not alter the ability of R to induce lytic EBV gene transcription. Therefore, C-mer activation may be important for some other aspect of lytic EBV infection. [ABSTRACT FROM AUTHOR]

Published
2004
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17. Co-occurrence of Functional Gonadotroph Adenoma and Lactotroph Adenoma: A Case Report and Literature Review.

Author

Ullah MT, Lopes MBS, Jane JA Jr, Hong GK, and Love KM

Abstract

Background/objective: Functional gonadotroph adenomas (FGAs) are adenomas producing active gonadotropins, follicle-stimulating hormone or luteinizing hormone. Double pituitary adenomas are 2 distinct adenomas occurring in an individual. This report aimed to present an extremely rare case of an FGA, itself an uncommon disorder, co-occurring with a lactotroph adenoma., Case Report: A 33-year-old woman presented with menorrhagia and was found to have ovarian enlargement, large uterine leiomyomas, and bitemporal hemianopsia. Initially, the levels of follicle-stimulating hormone, luteinizing hormone, estradiol, and prolactin were 73.3 mIU/mL (midcycle peak, 2.3-20.9 mIU/L), 3.74 mIU/L (midcycle peak, 8.7-76.3 mIU/L), 1071 pg/mL (midcycle peak 38-649 pg/mL), and 402 ng/mL (2-30 ng/mL), respectively. Pituitary magnetic resonance imaging demonstrated a single sellar mass (2.0 × 2.2 cm). Two months of cabergoline did not reverse visual field deficits; therefore, transsphenoidal resection was performed. Diagnosis of 2 separate adenomas, a gonadotroph and lactotroph adenoma, was confirmed on pathology., Discussion: In this case, gonadotropins did not suppress in response to hyperprolactinemia. Although marked hyperprolactinemia has been associated with functional and clinically silent gonadotroph adenomas in prior cases, this is the first case to confirm an FGA co-occurring with a lactotroph adenoma., Conclusion: In patients who present with elevated gonadotropin levels despite hyperprolactinemia, we suggest considering FGA. Further research is needed to clarify whether there is underdiagnosis of lactotroph adenomas co-occurring with gonadotroph adenomas., Competing Interests: The authors have no multiplicity of interest to disclose, (© 2022 Published by Elsevier Inc. on behalf of the AACE.)

Published
2022
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