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4. Genomic responses in mouse models poorly mimic human inflammatory diseases.

Author

Seok, Junhee, Warren, H, Cuenca, Alex, Mindrinos, Michael, Baker, Henry, Xu, Weihong, Richards, Daniel, McDonald-Smith, Grace, Gao, Hong, Hennessy, Laura, Finnerty, Celeste, López, Cecilia, Honari, Shari, Moore, Ernest, Minei, Joseph, Bankey, Paul, Johnson, Jeffrey, Sperry, Jason, Nathens, Avery, Billiar, Timothy, Jeschke, Marc, Klein, Matthew, Gamelli, Richard, Gibran, Nicole, Brownstein, Bernard, Miller-Graziano, Carol, Calvano, Steve, Mason, Philip, Cobb, J, Rahme, Laurence, Lowry, Stephen, Maier, Ronald, Moldawer, Lyle, Herndon, David, Davis, Ronald, Xiao, Wenzhong, Tompkins, Ronald, West, Michaela, and Cuschieri, Joseph

Subjects
Acute Disease, Adolescent, Adult, Animals, Burns, Disease Models, Animal, Endotoxemia, Female, Gene Expression Regulation, Genomics, Humans, Inflammation, Male, Mice, Mice, Inbred C57BL, Signal Transduction, Time Factors, Wounds and Injuries, Young Adult
Abstract

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Among genes changed significantly in humans, the murine orthologs are close to random in matching their human counterparts (e.g., R(2) between 0.0 and 0.1). In addition to improvements in the current animal model systems, our study supports higher priority for translational medical research to focus on the more complex human conditions rather than relying on mouse models to study human inflammatory diseases.

Published
2013

20. Abstract 6

Author

Sood, Ravi F., primary, Hocking, Anne M., additional, Muffley, Lara A., additional, Ga, Maricar, additional, Honari, Shari, additional, Alexander, Reiner P., additional, and Gibran, Nicole S., additional

Published
2015
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21. Benchmarking Outcomes in the Critically Injured Burn Patient

Author

Klein, Matthew B., primary, Goverman, Jeremy, additional, Hayden, Douglas L., additional, Fagan, Shawn P., additional, McDonald-Smith, Grace P., additional, Alexander, Andrew K., additional, Gamelli, Richard L., additional, Gibran, Nicole S., additional, Finnerty, Celeste C., additional, Jeschke, Marc G., additional, Arnoldo, Brett, additional, Wispelwey, Bram, additional, Mindrinos, Michael N., additional, Xiao, Wenzhong, additional, Honari, Shari E., additional, Mason, Philip H., additional, Schoenfeld, David A., additional, Herndon, David N., additional, and Tompkins, Ronald G., additional

Published
2014
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23. Correction: Harborview Burns – 1974 to 2009

Author

Engrav, Loren H., primary, Heimbach, David M., additional, Rivara, Frederick P., additional, Kerr, Kathleen F., additional, Osler, Turner, additional, Pham, Tam N., additional, Sharar, Sam R., additional, Esselman, Peter C., additional, Bulger, Eileen M., additional, Carrougher, Gretchen J., additional, Honari, Shari, additional, and Gibran, Nicole S., additional

Published
2013
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26. American Burn Association Consensus Statements

Author

Gibran, Nicole S., primary, Wiechman, Shelley, additional, Meyer, Walter, additional, Edelman, Linda, additional, Fauerbach, Jim, additional, Gibbons, Linda, additional, Holavanahalli, Radha, additional, Hunt, Carly, additional, Keller, Kelly, additional, Kirk, Elizabeth, additional, Laird, Jacqueline, additional, Lewis, Giavonni, additional, Moses, Sidonie, additional, Sproul, Jill, additional, Wilkinson, Gretta, additional, Wolf, Steve, additional, Young, Alan, additional, Yovino, Sandra, additional, Mosier, Michael J., additional, Cancio, Leopoldo C., additional, Amani, Hamed, additional, Blayney, Carolyn, additional, Cullinane, Judith, additional, Haith, Linwood, additional, Jeng, James C., additional, Kardos, Patricia, additional, Kramer, George, additional, Lawless, Mary Beth, additional, Serio-Melvin, Maria L., additional, Miller, Sidney, additional, Moran, Katie, additional, Novakovic, Rachel, additional, Potenza, Bruce, additional, Rinewalt, Anna, additional, Schultz, John, additional, Smith, Howard, additional, Dylewski, Maggie, additional, Wibbenmeyer, Lucy, additional, Bessey, Palmer Q., additional, Carter, Jennifer, additional, Gamelli, Richard, additional, Goodwin, Cleon, additional, Graves, Tamara, additional, Hollowed, Kathleen, additional, Holmes, Jimmy, additional, Noordenbas, John, additional, Nordlund, Megan, additional, Savetamal, Alisa, additional, Simpson, Peggie, additional, Traber, Daniel, additional, Traber, Lillian, additional, Nedelec, Bernadette, additional, Donelan, Matthias, additional, Baryza, Mary Jo, additional, Bhavsar, Dhaval, additional, Blome-Eberwein, Sigrid, additional, Carrougher, Gretchen J., additional, Hickerson, William, additional, Joe, Victor, additional, Jordan, Marion, additional, Kowalske, Karen, additional, Murray, Derek, additional, Murray, Vimal K., additional, Parry, Ingrid, additional, Peck, Michael, additional, Reilly, Debra, additional, Schneider, Jeffrey C., additional, Ware, Linda, additional, Singer, Adam J., additional, Boyce, Steven T., additional, Ahrenholz, David H., additional, Chang, Philip, additional, Clark, Richard A. F., additional, Fey, Ryan, additional, Fidler, Phil, additional, Garner, Warren, additional, Greenhalgh, David, additional, Honari, Shari, additional, Jones, Larry, additional, Kagan, Richard, additional, Kirby, John, additional, Leggett, Jeannie, additional, Meyer, Nicholas, additional, Reigart, Cynthia, additional, Richey, Karen, additional, Rosenberg, Lior, additional, Weber, Joan, additional, and Wiggins, Brad, additional

Published
2013
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27. Harborview Burns – 1974 to 2009

Author

Engrav, Loren H., primary, Heimbach, David M., additional, Rivara, Frederick P., additional, Kerr, Kathleen F., additional, Osler, Turner, additional, Pham, Tam N., additional, Sharar, Sam R., additional, Esselman, Peter C., additional, Bulger, Eileen M., additional, Carrougher, Gretchen J., additional, Honari, Shari, additional, and Gibran, Nicole S., additional

Published
2012
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28. Pressure Ulcers and Risk Assessment in Severe Burns

Author

Lewis, Giavonni M., primary, Pham, Tam N., additional, Robinson, Ellen, additional, Otto, Andrew, additional, Honari, Shari, additional, Heimbach, David M., additional, Klein, Matthew B., additional, and Gibran, Nicole S., additional

Published
2012
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41. Genomic responses in mouse models poorly mimic human inflammatory diseases.

Author

Junhee Seok, Warren, H. Shaw, Cuenca, Alex G., Mindrinos, Michael N., Baker, Henry V., Weihong Xu, Richards, Daniel R., McDonald-Smith, Grace P., Hong Gao, Hennessy, Laura, Finnerty, Celeste C., López, Cecilia M., Honari, Shari, Moore, Ernest E., Mine, Joseph P., Cuschieri, Joseph, Bankey, Paul E., Johnson, Jeffrey L., Sperry, Jason, and Nathens, Avery B.

Subjects
TRANSLATIONAL research, INFLAMMATION, IMMUNE response, LABORATORY mice, CLINICAL trials, ANIMAL models of immunology
Abstract

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Among genes changed significantly in humans, the murine orthologs are close to random in matching their human counterparts (e.g., R2 between 0.0 and 0.1). In addition to improvements in the current animal model systems, our study supports higher priority for translational medical research to focus on the more complex human conditions rather than relying on mouse models to study human inflammatory diseases. [ABSTRACT FROM AUTHOR]

Published
2013
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42. Summary of the 2012 ABA Burn Quality Consensus Conference

Author

Gibran, Nicole S., Wiechman, Shelley, Meyer, Walter, Edelman, Linda, Fauerbach, Jim, Gibbons, Linda, Holavanahalli, Radha, Hunt, Carly, Keller, Kelly, Kirk, Elizabeth, Laird, Jacqueline, Lewis, Giavonni, Moses, Sidonie, Sproul, Jill, Wilkinson, Gretta, Wolf, Steve, Young, Alan, Yovino, Sandra, Mosier, Michael J., Cancio, Leopoldo C., Amani, Hamed, Blayney, Carolyn, Cullinane, Judith, Haith, Linwood, Jeng, James C., Kardos, Patricia, Kramer, George, Lawless, Mary Beth, Serio-Melvin, Maria L., Miller, Sidney, Moran, Katie, Novakovic, Rachel, Potenza, Bruce, Rinewalt, Anna, Schultz, John, Smith, Howard, Dylewski, Maggie, Wibbenmeyer, Lucy, Bessey, Palmer Q., Carter, Jennifer, Gamelli, Richard, Goodwin, Cleon, Graves, Tamara, Hollowed, Kathleen, Holmes, Jimmy, Noordenbas, John, Nordlund, Megan, Savetamal, Alisa, Simpson, Peggie, Traber, Daniel, Traber, Lillian, Nedelec, Bernadette, Donelan, Matthias, Baryza, Mary Jo, Bhavsar, Dhaval, Blome-Eberwein, Sigrid, Carrougher, Gretchen J., Hickerson, William, Joe, Victor, Jordan, Marion, Kowalske, Karen, Murray, Derek, Murray, Vimal K., Parry, Ingrid, Peck, Michael, Reilly, Debra, Schneider, Jeffrey C., Ware, Linda, Singer, Adam J., Boyce, Steven T., Ahrenholz, David H., Chang, Philip, Clark, Richard A. F., Fey, Ryan, Fidler, Phil, Garner, Warren, Greenhalgh, David, Honari, Shari, Jones, Larry, Kagan, Richard, Kirby, John, Leggett, Jeannie, Meyer, Nicholas, Reigart, Cynthia, Richey, Karen, Rosenberg, Lior, Weber, Joan, and Wiggins, Brad

Published
2013
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43. Contributors

Author

Abel, Jenni Jordan, Al-Saden, Patrice C., Baird, Marianne Saunorus, Barrett, Laura, Benoit, Risa, Bethel, Susan, Bittel, Cheryl, Blayney, Carolyn, Callanan, Mimi, Carrougher, Gretchen J., Christensen, Cynthia Rebik, Cosby, A. Suzanne, Davis, Alice, Dirks, Joni, Freeland, Carey, George-Gay, Beverly, Good, Vicki, Gordon, Phyllis, Halvey, Kathleen, Hirsch, Adina Chaya, Honari, Shari, Kerber, Alice, Landreth, Cathie Osika, Leary, Laura Leigh, Liles, Lynda, McLean, Barbara, Mullaney, Mary Ann, Nickles, Barbara, Schmidt, Paul E., Scruth, Elizabeth, Steed, Connie, Warner, Joyce C., Weiskittel, Patricia, Zorn, Karen, Aldridge, Michael D., Alexander, Earnest, Amusina, Olga, Bradshaw, Patricia N., Bressie, Marylee Rollins, Broering, Beth, Brune, Mary, Buonocore, Denise, Byrum, Diane, Chioffi, Susan Marie, Cottrell, Damon, Cygan, Heide Rose, Dechant, Laura, Dirks, Joni L., Flanders, Sonya, Foresman-Capuzzi, Joyce, Graves, James, Hawkins, Joellen W., Holleran, Reneé S., Konopka, Barbara, Kudomovic, Adisa Tokacha, Lamb, Robert E., Leary, Sheryl E., Lee, Rosemary Koehl, Mann, Elizabeth A., Mendeloff, Elizabeth M., Neumiller, Joshua J., Owens, Christopher T., Paul, Michaelynn, Phelps, Beth Anne, Powers, Jan, Rouse, Candace L., Setter, Stephen M., Sheets, Eva, Sutherland, Suzanne, Thurman, Paul, Widener, Jeanne Malcom, Wood, Lindy D., and Zielinski, Tresa E.

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44. Evaluation of Burn Rounds Using Telemedicine: Perspectives from Patients, Families, and Burn Center Staff.

Author

Yenikomshian HA, Lerew TL, Tam M, Mandell SP, Honari SE, and Pham TN

Subjects
Adolescent, Adult, Aged, Attitude of Health Personnel, Cooperative Behavior, Family psychology, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Patient Satisfaction, Videoconferencing organization & administration, Young Adult, Burn Units organization & administration, Burns therapy, Patient Care Team organization & administration, Teaching Rounds organization & administration, Telemedicine organization & administration
Abstract

Introduction: Burn care requires multiple disciplines to collaborate to achieve best patient care. Because of this, rounds involve a very large burn team to assess patients' wounds and formulate plans. To decrease the amount of team members on rounds, our burn center implemented a new budding technology: telemedicine. We created "Zoom Rounds," a Health Insurance Portability and Accountability Act (HIPAA)-compliant, secure videoconferencing system to relay patient wound evaluations to a remote conference room where team members can participate digitally. We sought to evaluate this new rounding process by querying the burn team, patients, and families regarding their experience., Methods: Surveys were developed for each group and were distributed over a 2-month period. Respondents were asked to rate the videoconferencing rounding experience and comment on the educational experience (staff/providers) and one's personal experience (patient/family). We analyzed both the quantitative data with the qualitative responses. Qualitative data analysis for content was used to independently code and analyze responses to the open-ended survey questions by two authors and verified by adjudication review., Results: Thirty-three patients/families and 69 burn staff members completed the confidential survey (response rate of 90% and 83%, respectively). Coded responses identified several themes: inconsistent technology, improved visualization and communication regarding the wounds, better learning experience, and improved patient experience by decreased crowds in the room., Conclusions: There was strong support for the use of videoconferencing for patient wound rounds among providers, burn center staff, and patients/families. Telemedicine is a promising technology to improve inpatient burn rounds.

Published
2019
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45. The optimal time for early excision in major burn injury.

Author

Muangman P, Sullivan SR, Honari S, Engrav LH, Heimbach DM, and Gibran NS

Subjects
Adult, Analysis of Variance, Burns mortality, Burns pathology, Female, Humans, Length of Stay, Male, Retrospective Studies, Survival Rate, Time Factors, Wound Infection epidemiology, Wound Infection mortality, Wound Infection pathology, Burns surgery, Skin Transplantation
Abstract

Introduction: Early excision and grafting (E&G) drastically changed burn care in America by reducing morbidity, mortality and hospital length of stay (LOS). The present study was intended to determine whether an optimal time window exists between resuscitation and wound sepsis for the first E&G in a patient with a large burn., Material and Method: The authors conducted a retrospective study of patients admitted between January 1994 and December 2000 with > or = 40% TBSA burns and at least 1 E&G procedure. Patients were grouped according to the day of their first operation. Patients allowed to heal indeterminate burns prior to excision and grafting of deep partial or full thickness burns were grouped as > or = d7 and were excluded from the present study. The authors correlated the time of first excision with infection, mortality and LOS., Results: Seventy-five patients were identified and 12 patients allowed to heal indeterminate burn prior to excision and grafting of deep partial or full thickness burns were excluded. Sixty-three remaining patients included 51 males and 12 females. Mean burn size was 49% of total body surface area (TBSA) (44% deep partial or full thickness) and the mean age was 36 years. There were 61 flame (2 combined with electrical injuries), 1 scald and 1 chemical burn. Twelve died (19%) and 52 patients developed 121 infections. Whereas there was no statistical difference in mortality for patients operated on different days (p > 0.2), 60% of patients operated within the first 48 hours after injury died; this was not significant due to a small patient number, Conclusions: The present data suggest that patients who undergo early excision and grafting within seven days following a major burn > or = 40% TBSA have equivalent infection or mortality rates regardless of when the first operation occurs between post burn day(PBD) 2 and PBD 7 (p > 0.2).

Published
2006

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