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797 results on '"Hommel M"'

1. Incidence and Outcomes of Patients With Early Cardiac Complications After Intracerebral Hemorrhage: A Report From VISTA

Author

Ishiguchi, Hironori, Huang, Bi, El-Bouri, Wahbi K., Dawson, Jesse, Lip, Gregory Y.H., Abdul-Rahim, Azmil H., Lees, K.R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Chen, C., Claesson, L., Curram, J., Davis, S.M., Diener, H-C., Donnan, G., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Roffe, C., Sacco, R., Shuaib, A., Teal, P., Venketasubramanian, N., Wahlgren, N.G., and Warach, S.

Published
2024
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2. Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set

Author

Ali, Myzoon, Tibble, Holly, Brady, Marian C., Quinn, Terence J., Sunnerhagen, Katharina S., Venketasubramanian, Narayanaswamy, Shuaib, Ashfaq, Pandyan, Anand, Mead, Gillian, Lees, K.R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Chen, C., Claesson, L., Curram, J., Davis, S.M., Diener, H-C., Donnan, G., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste (Emeritus), M., Lyden, P., Marler, J., Muir, K., Roffe, C., Teal, P., Wahlgren, N.G., Warach, S., Ali, M., Ashburn, A., Barer, D., Barzel, A., Bernhardt, J., Bowen, A., Drummond, A., Edmans, J., English, C., Gladman (Emeritus), J., Godecke, E., Hiekkala, S., Hoffman, T., Kalra, L., Kuys, S., Langhorne, P., Laska, A.C., Lees, K.R., Logan, P., Machner, B., Morris, J., Pollock, A., Pomeroy, V., Rodgers, H., Sackley, C., Shaw, L., Stott, D.J., Tyson, S., van Vliet, P., Walker, M., Whiteley, W., Hanley, D.F., Butcher, K., Davis, S., Gregson, B., Lees, K.R., Lyden, P., Mayer, S., Muir, K., and Steiner, T.

Published
2023
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3. Reduction of Prolonged Excessive Pressure in Seated Persons With Paraplegia Using Wireless Lingual Tactile Feedback: A Randomized Controlled Trial

Author

Moreau-Gaudry, A., Chenu, O., Dang, M., Bosson, J. L., Hommel, M., Demongeot, J., Cannard, F., Diot, B., Prince, A., Hughes, C., Vuillerme, Nicolas, and Payan, Yohan

Subjects
Physics - Medical Physics
Abstract

Pressure ulcers (PU) are known to be a high-cost disease with a risk of severe morbidity. This work evaluates a new clinical strategy based on an innovative medical device (Tongue Display Unit-TDU) that implements perceptive supplementation in order to reduce prolonged excessive pressure, recognized as one of the main causes of PU. A randomized, controlled, parallel-group trial was carried out with 12 subjects with spinal cord injuries (SCI). Subjects were assigned to the control (without TDU, n=6) or intervention (with TDU, n=5) group. Each subject took part in two sessions, during which the subject, seated on a pressure map sensor, watched a movie for one hour. The TDU was activated during the second session of the intervention group. Intention-to-treat analysis showed that the improvement in adequate weight shifting between the two sessions was higher in the intervention group (0.84 [0.24; 0.89]) than in the control group (0.01 [-0.01; 0.09]; p=0.004) and that the ratio of prolonged excessive pressure between the two sessions was lower in the intervention group (0.74 [0.37; 1.92]) than in the control group (1.72 [1.32; 2.56]; p=0.06). The pressure map sensor was evaluated as being convenient for use in daily life, however this was not the case for the TDU. This work shows that persons with SCI could benefit from a system based on perceptive supplementation that alerts and guides the user on how to adapt their posture in order to reduce prolonged excessive pressure, one of the main causes of PU.

Published
2018
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5. Pharmacological therapies in post stroke recovery: recommendations for future clinical trials.

Author

Chollet, F, Cramer, SC, Stinear, C, Kappelle, LJ, Baron, JC, Weiller, C, Azouvi, P, Hommel, M, Sabatini, U, Moulin, T, Tardy, J, Valenti, M, Montgomery, S, and Adams, H

Subjects
Humans, Neuroprotective Agents, Recovery of Function, Clinical Trials as Topic, Stroke, Stroke recovery, Brain plasticity, Pharmacology, Clinical trials, Clinical scales, Outcome scales, Statistical analysis, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

Stroke is a leading cause of serious long-term disability in adults and is the second leading cause of death worldwide. Early reperfusion and neuroprotection techniques have been the focus of much effort with the aim of very acute treatment of the stroke. Targeting different mechanisms, pharmacological therapies have the potential to reduce disability in a large fraction of patients who survive the acute stroke. The brain's capacity to reorganize after stroke through plasticity mechanisms can be modulated by pharmacological agents. A number of therapeutic interventions are under study, including small molecules, growth factors, and monoclonal antibodies. Recently it has been shown that the SSRI fluoxetine improved motor deficit in patients with ischaemic stroke and hemiplegia which appeared to be independent of the presence of depression. In this context, it is of major importance to support innovative research in order to promote the emergence of new pharmacological treatments targeting neurological recovery after stroke, as opposed to acute de-occlusion and neuroprotection. This paper is the work of a group of 14 scientists with aim of (1) addressing key areas of the basic and clinical aspects of human brain plasticity after stroke and potential pharmacological targets for recovery, (2) asking questions about the most appropriate characteristics of clinical trials testing drugs in post stroke recovery and (3) proposing recommendations for future clinical trials.

Published
2014

14. Sex and Stroke in Thrombolyzed Patients and Controls

Author

Hametner, Christian, MacIsaac, Rachael L., Kellert, Lars, Abdul-Rahim, Azmil H., Ringleb, Peter A., Lees, Kennedy R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Chen, C., Claesson, L., Davis, S.M., Donnan, G., Diener, H.C., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Venketasubramanian, N., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N.G., Warach, S., and Weimar, C.

Published
2017
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17. Temporal Profile of Pneumonia After Stroke

Author

de Jonge, Jeroen C., primary, van de Beek, Diederik, additional, Lyden, Patrick, additional, Brady, Marian C., additional, Bath, Philip M., additional, van der Worp, H. Bart, additional, Lees, K.R., additional, Alexandrov, A., additional, Berge, E., additional, Bluhmki, E., additional, Bornstein, N., additional, Chen, C., additional, Claesson, L., additional, Davis, S.M., additional, Donnan, G., additional, Diener, H.C., additional, Fisher, M., additional, Ginsberg, M., additional, Gregson, B., additional, Grotta, J., additional, Hacke, W., additional, Hennerici, M.G., additional, Hommel, M., additional, Kaste, M., additional, Marler, J., additional, Muir, K., additional, Venketasubramanian, N., additional, Sacco, R., additional, Shuaib, A., additional, Teal, P., additional, Wahlgren, N.G., additional, Warach, S., additional, and Weimar, C., additional

Published
2022
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18. Transcatheter Aortic Valve Implantation for Severe Aortic Regurgitation in Patients with Left Ventricular Assist Device Support

Author

Lanmueller, P., additional, Eulert-Grehn, J. J., additional, Unbehaun, A., additional, Klein, C., additional, Hommel, M., additional, Kofler, M., additional, Kempfert, J., additional, Hörmadinger, C., additional, Kaufmann, F., additional, Stawowy, P., additional, Dreysse, S., additional, Mulzer, J., additional, Müller, M., additional, Falk, V., additional, Schönrath, F., additional, Potapov, E., additional, and Just, I., additional

Published
2022
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21. β-Blockers, Pneumonia, and Outcome After Ischemic Stroke: Evidence From Virtual International Stroke Trials Archive

Author

Sykora, Marek, Siarnik, Pavel, Diedler, Jennifer, Lees, K.R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Claesson, L., Davis, S.M., Donnan, G., Diener, H. C., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N.G., Warach, S., and Weimar, C.

Published
2015
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23. P27.06 Multiscale NSCLC Tumor Growth Knowledge-Based Model Reproduces Tumor-Non-Progression under Gefitinib

Author

L'Hostis, A., primary, Palgen, J., additional, Ceres, N., additional, Peyronnet, E., additional, Perrillat-Mercerot, A., additional, Schneider, A., additional, Margreiter, M., additional, Jacob, E., additional, Kahoul, R., additional, Illigens, B., additional, Hommel, M., additional, Boissel, J., additional, Bosley, J., additional, and Monteiro, C., additional

Published
2021
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24. P71.05 Use of a Multiscale NSCLC Tumor Heterogeneity Model to Predict Tumor Growth Under Gefitinib

Author

L'Hostis, A., primary, Palgen, J., additional, Ceres, N., additional, Peyronnet, E., additional, Perrillat-Mercerot, A., additional, Schneider, A., additional, Margreiter, M., additional, Jacob, E., additional, Kahoul, R., additional, Illigens, B., additional, Hommel, M., additional, Boissel, J., additional, Bosley, J., additional, and Monteiro, C., additional

Published
2021
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29. National Institutes of Health Stroke Scale Item Profiles as Predictor of Patient Outcome: External Validation on Independent Trial Data

Author

Abdul-Rahim, Azmil H., Fulton, Rachael L., Sucharew, Heidi, Kleindorfer, Dawn, Khatri, Pooja, Broderick, Joseph P., Lees, Kennedy R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Claesson, L., Curram, J., Davis, S.M., Donnan, G., Diener, H.C., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N.G., Warach, S., and Weimar, C.

Published
2015
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30. Associations of chronic heart failure with outcome in acute ischaemic stroke patients who received systemic thrombolysis: analysis from VISTA

Author

Abdul-Rahim, A. H., Fulton, R. L., Frank, B., McMurray, J. J. V., Lees, K. R., Alexandrov, A. V., Bath, P. W., Bluhmki, E., Claesson, L., Curram, J., Davis, S. M., Donnan, G., Diener, H. C., Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N. G., Warach, S., and Weimar, C.

Published
2015
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31. Characteristic Adverse Events and Their Incidence Among Patients Participating in Acute Ischemic Stroke Trials

Author

Hesse, Kerrick, Fulton, Rachael L., Abdul-Rahim, Azmil H., Lees, Kennedy R., Alexandrov, A.V., Bath, P.W., Bluhmki, E., Claesson, L., Curram, J., Davis, S.M., Donnan, G., Diener, H.C., Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N.G., Warach, S., and Weimar, C.

Published
2014
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34. Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants

Author

Conde-Gallastegi, E. (Enrique), Vercher-Herráez, E. (Enric), Soria-Castellano, M. (Marta), Suarez-Olmos, J. (Jesús), Mancheño, U. (Uxua), Elizalde, E. (Edurne), Rodríguez, M.L. (M. Luis), González-Vaz, J. (Javier), Casares, N. (Noelia), Rodríguez-García, E. (Estefanía), Hommel, M. (Mirja), González-Aseguinolaza, G. (Gloria), Uranga-Murillo, I. (Iratxe), Pardo, J. (Julián), Alkorta-Aranburu, G. (Gorka), Melero, I. (Ignacio), Lasarte, J.J. (Juan José), and Hervas-Stubbs, S. (Sandra)

Subjects
Chimeric antigen, Adaptive immunity, Adoptive, Receptors, Tumor escape, Combined modality therapy, Immunotherapy
Abstract

Background Target antigen (Ag) loss has emerged as a major cause of relapse after chimeric antigen receptor T (CART)-cell therapy. We reasoned that the combination of CART cells, with the consequent tumor debulking and release of Ags, together with an immunomodulatory agent, such as the stimulator of interferon gene ligand (STING-L) 2 ' 3 '-cyclic GMP-AMP (2 ' 3 '-cGAMP), may facilitate the activation of an endogenous response to secondary tumor Ags able to counteract this tumor escape mechanism. Methods Mice bearing B16-derived tumors expressing prostate-specific membrane Ag or gp75 were treated systemically with cognate CART cells followed by intratumoral injections of 2 ' 3 '-cGAMP. We studied the target Ag inmunoediting by CART cells and the effect of the CART/STING-L combination on the control of STING-L-treated and STING-L-non-treated tumors and on the endogenous antitumor T-cell response. The role of Batf3-dependent dendritic cells (DCs), stimulator of interferon gene (STING) signaling and perforin (Perf)-mediated killing in the efficacy of the combination were analyzed. Results Using an immune-competent solid tumor model, we showed that CART cells led to the emergence of tumor cells that lose the target Ag, recreating the cancer immunoediting effect of CART-cell therapy.

Published
2021

36. THRIVE Score Predicts Ischemic Stroke Outcomes and Thrombolytic Hemorrhage Risk in VISTA

Author

Flint, Alexander C., Faigeles, Bonnie S., Cullen, Sean P., Kamel, Hooman, Rao, Vivek A., Gupta, Rishi, Smith, Wade S., Bath, Philip M., Donnan, Geoffrey A., Lees, K.R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Claesson, L., Davis, S.M., Donnan, G., Diener, H.C., Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N.G., Warach, S., and Weimar, C.

Published
2013
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37. Does the cognitive measure Cog-4 show improvement among patients treated with thrombolysis after acute stroke?

Author

Hajjar, Karim, Fulton, Rachael L., Diener, Hans-Christoph, Lees, Kennedy R., Alexandrov, A, Bath, PMW, Bluhmki, E, Claesson, L, Curram, J, Davis, SM, Donnan, G, Diener, HC, Fisher, M, Gregson, B, Grotta, J, Hacke, W, Hennerici, MG, Hommel, M, Kaste, M, Lees, KR, Lyden, P, Marler, J, Muir, K, Sacco, R, Shuaib, A, Teal, P, Wahlgren, NG, Warach, S, and Weimar, C

Published
2013
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38. How Well Do Standard Stroke Outcome Measures Reflect Quality of Life?: A Retrospective Analysis of Clinical Trial Data

Author

Ali, Myzoon, Fulton, Rachael, Quinn, Terry, Brady, Marian, Lees, K. R., Alexandrov, A., Bath, P. M., Bluhmki, E., Bornstein, N., Claesson, L., Davis, S. M., Donnan, G., Diener, H. C., Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N. G., Warach, S., Weimar, C., Brady, M., Ali, M., Ashburn, A., Barer, D., Bernhardt, J., Bowen, A., Brodie, E., Corr, S., Drummond, A., Edmans, J., English, C., Gladman, J., Godecke, E., Hoffmann, T., Kalra, L., Kuys, S., Langhorne, P., Laska, A. C., Lees, K. R., Lincoln, N., Logan, P., Jongbloed, L., Mead, G., Pollock, A., Pomeroy, V., Rodgers, H., Sackley, C., Shaw, L., Stott, D. J., Sunnerhagen, K. S., Tyson, S., van Vliet, P., Walker, M., Whiteley, W., Warach, S., Albers, G., Davis, S., Donnan, G., Fisher, M., Furlan, T., Grotta, J., Hacke, W., Kidwell, C., Koroshetz, W., Lees, K. R., Lev, M., Liebeskind, D., Sorensen, G., Thijs, V., Thomalla, G., Wardlaw, J., Wintermark, M., Hanley, D. F., Gregson, B., Davis, S., Lees, K. R., Lyden, P., Muir, K., Steiner, T., Mayer, S., Wahlgren, N. G., Molina, C., Numminen, H., Lees, K. R., Tsivgoulis, G., Weimar, C., Diener, H. -C., Hankey, G., Lees, K. R., Ovbiagele, B., and Weir, C.

Published
2013
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48. MINS (Myocardial Injury after Non-Cardiac Surgery).

Author

Bosse, G., Friebel, J., Ernst, M., Klages, J., Ruetzler, K., Landmesser, U., Hommel, M., and O'Brien, B.

Subjects
ATHEROSCLEROSIS risk factors, MYOCARDIAL infarction complications, MYOCARDIAL infarction-related mortality, TROPONIN, OPERATIVE surgery, MYOCARDIAL ischemia, SURGICAL complications, MYOCARDIAL reperfusion complications, HYPOTENSION, DISEASE risk factors, DISEASE complications
Abstract

Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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