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166 results on '"Holzhauser T"'

5. List of contributors

Author

Adachi, R., primary, Arrowsmith, H.E., additional, Baumert, J.L., additional, Brown, H.M., additional, Chen, Y., additional, Ciclitira, P.J., additional, Crevel, R.W.R., additional, Deng, T.T., additional, Flanagan, S., additional, Goodman, R.E., additional, Gowland, M.H., additional, Hamilton, R.G., additional, Han, J.X., additional, Hipkiss, J., additional, Hirst, B., additional, Holzhauser, T., additional, Immer, U., additional, Lacorn, M., additional, Löwik, D.W.P.M., additional, Messing, J., additional, Miguel, S.J., additional, Millard, P., additional, Nasr, I.H., additional, Nasr, I., additional, Nikoleiski, D., additional, O’Hagan, S., additional, Paine, S., additional, Panda, R., additional, Remington, B.C., additional, Röder, M., additional, Sakai, S., additional, Stein, K., additional, Taylor, S.L., additional, Teshima, R., additional, Tran, D.H., additional, van Delft, F.L., additional, van Hest, J.C.M., additional, Wal, J.M., additional, Wammes, A.E.M., additional, Wang, P., additional, Wang, W., additional, Ward, R.K., additional, Wong, G.W.K., additional, and Wu, Y.J., additional

Published
2015
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10. COST Action 'ImpARAS': What have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium

Author

Verhoeckx, K., Bøgh, K. lindholm, Constable, A., Epstein, M.M., Sommergruber, K. hoffmann, Holzhauser, T., Houben, G., Kuehn, A., Roggen, E., O'Mahony, L., Remington, B., and Crevel, R.

Subjects
Cross reaction, Allergic reaction, Methodology, In vitro study, Nonhuman, Sensitization, Physical chemistry, Allergenicity, Decision-making criteria, Food allergy, Allergy risk assessment, De novo sensitisation, Prediction, Decision making, Human, Risk assessment
Abstract

The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated allergenicity risk assessment strategy. The COST (Cooperation in Science and Technology) Action ImpARAS (Improved Allergenicity Risk Assessment Strategy), a four-year networking project, identified gaps in current allergy risk assessment, and proposed new ideas and plans for improving it. Here, we report on the lessons learned from the ImpARAS network and suggestions for future research. The safe introduction of novel and more sustainable food protein sources, while protecting humans from food allergy, calls for a multidisciplinary approach based on an improved understanding of what determines the relative allergenic potency of proteins, novel testing and assessment methodologies, harmonized decision-making criteria, and a clear ranking approach to express the allergenicity of novel product relative to that of existing known allergenic proteins: (from 'non'/to weakly and to strongly allergenic proteins). © 2020 The Author(s).

Published
2020

21. BASALIT trial: double‐blind placebo‐controlled allergen immunotherapy with rBet v 1‐FV in birch‐related soya allergy

Author

Treudler, R., primary, Franke, A., additional, Schmiedeknecht, A., additional, Ballmer‐Weber, B., additional, Worm, M., additional, Werfel, T., additional, Jappe, U., additional, Biedermann, T., additional, Schmitt, J., additional, Brehler, R., additional, Kleinheinz, A., additional, Kleine‐Tebbe, J., additional, Brüning, H., additional, Ruëff, F., additional, Ring, J., additional, Saloga, J., additional, Schäkel, K., additional, Holzhauser, T., additional, Vieths, S., additional, and Simon, J. C., additional

Published
2017
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22. EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies: Understanding food consumption, meeting regulations and identifying unmet needs

Author

Muraro, A. Hoffmann-Sommergruber, K. Holzhauser, T. Poulsen, L.K. Gowland, M.H. Akdis, C.A. Mills, E.N.C. Papadopoulos, N. Roberts, G. Schnadt, S. Van Ree, R. Sheikh, A. Vieths, S.

Subjects
digestive, oral, and skin physiology
Abstract

Individuals suffering from IgE-mediated food allergy usually have to practise life-long food allergen avoidance. This document aims to provide an overview of recent evidence-based recommendations for allergen risk assessment and management in the food industry and discusses unmet needs and expectations of the food allergic consumer in that context. There is a general duty of care on the food industry and obligations in European Union legislation to reduce and manage the presence of allergens alongside other food hazards. Current evidence enables quantification of allergen reference doses used to set-up reliable food safety management plans for some foods. However, further work is required to include a wider variety of foods and to understand the impact of the food matrix as well as additional factors which affect the progression and severity of symptoms as a function of dose. Major concerns have been raised by patients, carers and patient groups about the use of precautionary 'may contain' labelling to address the issue of unintended presence of allergens; these therefore need to be reconsidered. New and improved allergen detection methods should be evaluated for their application in food production. There is an urgent requirement for effective communication between healthcare professionals, patient organizations, food industry representatives and regulators to develop a better approach to protecting consumers with food allergies. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Published
2014

23. Standardization of double blind placebo controlled food challenge with soy within a multicentre trial

Author

Treudler, R., primary, Franke, A., additional, Schmiedeknecht, A., additional, Ballmer-Weber, B. K., additional, Worm, M., additional, Werfel, T., additional, Jappe, U., additional, Biedermann, T., additional, Schmitt, J., additional, Brehler, R., additional, Kleinheinz, A., additional, Kleine-Tebbe, J., additional, Brüning, H., additional, Ruëff, F., additional, Ring, J., additional, Saloga, J., additional, Schäkel, K., additional, Holzhauser, T., additional, Vieths, St., additional, and Simon, J. C., additional

Published
2016
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24. The conformational IgE epitope profile of soya bean allergen Gly m 4

Author

Husslik, F., primary, Nürnberg, J., additional, Seutter von Loetzen, C., additional, Mews, T., additional, Ballmer-Weber, B. K., additional, Kleine-Tebbe, J., additional, Treudler, R., additional, Simon, J.-C., additional, Randow, S., additional, Völker, E., additional, Reuter, A., additional, Rösch, P., additional, Vieths, S., additional, Holzhauser, T., additional, and Schiller, D., additional

Published
2016
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26. Standardization of allergen products: 3. Validation of candidate European Pharmacopoeia standard methods for quantification of major birch allergen Bet v 1

Author

Kaul, S., primary, Zimmer, J., additional, Dehus, O., additional, Costanzo, A., additional, Daas, A., additional, Buchheit, K. H., additional, Asturias, J. A., additional, Barber, D., additional, Carnés, J., additional, Chapman, M., additional, Dayan‐Kenigsberg, J., additional, Döring, S., additional, Führer, F., additional, Hanschmann, K. M., additional, Holzhauser, T., additional, Ledesma, A., additional, Moingeon, P., additional, Nony, E., additional, Pini, C., additional, Plunkett, G., additional, Reese, G., additional, Sandberg, E., additional, Sander, I., additional, Strecker, D., additional, Valerio, C., additional, van Ree, R., additional, and Vieths, S., additional

Published
2016
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27. Food processing and allergenicity

Author

Verhoeckx, K.C.M., Vissers, Y.M., Baumert, J.L., Faludi, R., Feys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., Bolt, N. van der, Wichers, H., Kimber, I., Verhoeckx, K.C.M., Vissers, Y.M., Baumert, J.L., Faludi, R., Feys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., Bolt, N. van der, Wichers, H., and Kimber, I.

Abstract

Food processing can have many beneficial effects. However, processing may also alter the allergenic properties of food proteins. A wide variety of processing methods is available and their use depends largely on the food to be processed. In this review the impact of processing (heat and non-heat treatment) on the allergenic potential of proteins, and on the antigenic (IgG-binding) and allergenic (IgE-binding) properties of proteins has been considered. A variety of allergenic foods (peanuts, tree nuts, cows' milk, hens' eggs, soy, wheat and mustard) have been reviewed. The overall conclusion drawn is that processing does not completely abolish the allergenic potential of allergens. Currently, only fermentation and hydrolysis may have potential to reduce allergenicity to such an extent that symptoms will not be elicited, while other methods might be promising but need more data. Literature on the effect of processing on allergenic potential and the ability to induce sensitisation is scarce. This is an important issue since processing may impact on the ability of proteins to cause the acquisition of allergic sensitisation, and the subject should be a focus of future research. Also, there remains a need to develop robust and integrated methods for the risk assessment of food allergenicity. © 2015 The Authors. Chemicals/CAS: immunoglobulin E, 37341-29-0; immunoglobulin G, 97794-27-9

Published
2015

28. Food Processing and Allergenicity

Author

Verhoeckx, K., Vissers, Y., Baumert, J.L., Faludi, R., Fleys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., van der Bolt, Nieke, Wichers, H.J., Kimber, I., Verhoeckx, K., Vissers, Y., Baumert, J.L., Faludi, R., Fleys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., van der Bolt, Nieke, Wichers, H.J., and Kimber, I.

Abstract

Food processing can have many beneficial effects. However, processing may also alter the allergenic properties of food proteins. A wide variety of processing methods is available and their use depends largely on the food to be processed.In this review the impact of processing (heat and non-heat treatment) on the allergenic potential of proteins, and on the antigenic (IgG-binding) and allergenic (IgE-binding) properties of proteins has been considered. A variety of allergenic foods (peanuts, tree nuts, cows' milk, hens' eggs, soy, wheat and mustard) have been reviewed.The overall conclusion drawn is that processing does not completely abolish the allergenic potential of allergens. Currently, only fermentation and hydrolysis may have potential to reduce allergenicity to such an extent that symptoms will not be elicited, while other methods might be promising but need more data. Literature on the effect of processing on allergenic potential and the ability to induce sensitisation is scarce. This is an important issue since processing may impact on the ability of proteins to cause the acquisition of allergic sensitisation, and the subject should be a focus of future research. Also, there remains a need to develop robust and integrated methods for the risk assessment of food allergenicity.

Published
2015

29. EAACI Food Allergy and Anaphylaxis Guidelines. Protecting consumers with food allergies:understanding food consumption, meeting regulations and identifying unmet needs

Author

Muraro, A, Hoffmann-Sommergruber, K, Holzhauser, T, Poulsen, Lars K., Gowland, Mh, Akdis, Ca, Mills, Enc, Papadopoulos, N, Roberts, G, Schnadt, S, van Ree, R, Sheikh, Aziz, Vieths, S, Muraro, A, Hoffmann-Sommergruber, K, Holzhauser, T, Poulsen, Lars K., Gowland, Mh, Akdis, Ca, Mills, Enc, Papadopoulos, N, Roberts, G, Schnadt, S, van Ree, R, Sheikh, Aziz, and Vieths, S

Abstract

Individuals suffering from IgE-mediated food allergy usually have to practice life-long food allergen avoidance. This document aims to provide an overview of recent evidence-based recommendations for allergen risk assessment and management in the food industry and discusses unmet needs and expectations of the food allergic consumer in that context. There is a general duty of care on the food industry and obligations in European Union legislation to reduce and manage the presence of allergens alongside other food hazards. Current evidence enables quantification of allergen reference doses used to set up reliable food safety management plans for some foods. However further work is required to include a wider variety of foods and to understand the impact of the food matrix as well as additional factors which affect the progression and severity of symptoms as a function of dose. Major concerns have been raised by patients, carers and patient groups about the use of precautionary 'may contain' labelling to address issue of unintended presence of allergens; these therefore need to be reconsidered. New and improved allergen detection methods should be evaluated for their application in food production. There is an urgent requirement for effective communication between health care professionals, patient organizations, food industry representatives and regulators to develop a better approach to protecting consumers with food allergies. This article is protected by copyright. All rights reserved.

Published
2014

31. Component-resolved in vitro diagnosis of carrot allergy in three different regions of Europe

Author

Ballmer-Weber, B K, Skamstrup Hansen, K, Sastre, J, Andersson, Klas Olof Daniel, Bätscher, I, Ostling, J, Dahl, L, Hanschmann, K-M, Holzhauser, T, Poulsen, Lars K., Lidholm, J, Vieths, S, Ballmer-Weber, B K, Skamstrup Hansen, K, Sastre, J, Andersson, Klas Olof Daniel, Bätscher, I, Ostling, J, Dahl, L, Hanschmann, K-M, Holzhauser, T, Poulsen, Lars K., Lidholm, J, and Vieths, S

Abstract

Carrot is a frequent cause of food allergy in Europe. The objective of this study was to evaluate a panel of carrot allergens for diagnosis of carrot allergy in Spain, Switzerland and Denmark.

Published
2012

33. Soybean allergen detection methods--a comparison study

Author

Pedersen, M. Højgaard, Holzhauser, T., Bisson, C., Conti, A., Jensen, Louise Bjerremann, Skov, P.S., Bindslev-Jensen, C., Brinch, D.S., Poulsen, Lars K., Pedersen, M. Højgaard, Holzhauser, T., Bisson, C., Conti, A., Jensen, Louise Bjerremann, Skov, P.S., Bindslev-Jensen, C., Brinch, D.S., and Poulsen, Lars K.

Abstract

Soybean containing products are widely consumed, thus reliable methods for detection of soy in foods are needed in order to make appropriate risk assessment studies to adequately protect soy allergic patients. Six methods were compared using eight food products with a declared content of soy: a direct sandwich ELISA based on polyclonal rabbit antibody (ab) to raw soy flakes, a commercial and an in-house competitive ELISA both based on ab to denatured, 'renatured' soy protein, an enzyme-allergosorbent test (EAST) inhibition based on two sera from soy allergic patients, histamine release (HR) using basophils passively sensitized with patient serum and a PCR method detecting soy DNA. Eight food products were selected as model foods to test the performance of the methods. There was an overall good agreement between the methods in terms of ranks of soy content but not the quantity. The sandwich ELISA aimed at native soy proteins had the lowest detection limit of 0.05 ppm, but only identified soy in 5/8 products, and generally in lower amounts compared to other methods. The competitive ELISA had a higher detection limit of 21 ppm, but seemed more successful in detecting processed soy. Only HR, EAST inhibition and PCR detected soy in all eight products. In spite of a general good correlation in terms of ranks of soy content, more than a single method may be necessary to confirm the presence of soy in foods Udgivelsesdato: 2008/12

Published
2008

35. Immunoglobulin E and G4 epitopes of the major allergen of birch pollen Bet v 1 share residues critical for antibody binding

Author

Groh, N, primary, Subbarayal, B, additional, Vogel, L, additional, Möbs, C, additional, de Jong, NW, additional, Pfützner, W, additional, van Wijk, RG, additional, Lidholm, J, additional, Meisel, L, additional, Randow, S, additional, Holzhauser, T, additional, Bohle, B, additional, Vieths, S, additional, and Schiller, D, additional

Published
2013
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36. The europrevall allergen library: a collection of high quality purified natural and recombinant allergens for in vitro diagnosis

Author

Hoffmann-Sommergruber, K., Sanch, A., Holzhauser, T., Skov, P., Alessandri, S., Wal, J., Rigby, N., Marsh, J., Bernard, H., Gaier, S., Lauer, I., Ma, Y., Oberhuber, C., Barkholt, Vibeke, Griesmeier, U., Bublin, M., Radauer, C., Scheurer, S., Reese, G., Zuidmeer, L., Akkerdaas, J., Neubauer, A., Fernandez-Rivas, M., Ballmer-Weber, B., Vieths, S., van Ree, R., Shewry, P., Mills, C., Hoffmann-Sommergruber, K., Sanch, A., Holzhauser, T., Skov, P., Alessandri, S., Wal, J., Rigby, N., Marsh, J., Bernard, H., Gaier, S., Lauer, I., Ma, Y., Oberhuber, C., Barkholt, Vibeke, Griesmeier, U., Bublin, M., Radauer, C., Scheurer, S., Reese, G., Zuidmeer, L., Akkerdaas, J., Neubauer, A., Fernandez-Rivas, M., Ballmer-Weber, B., Vieths, S., van Ree, R., Shewry, P., and Mills, C.

Published
2007

37. Diagnostik I

Author

Becker, W., primary, Jappe, U., additional, Kreft, B., additional, Ludwig, A., additional, Przybilla, B., additional, Walker, A., additional, Biedermann, T., additional, Raulf-Heimsoth, M., additional, Sültz, J., additional, Petersen, A., additional, Seppälä, U., additional, Dauly, C., additional, Robinson, S., additional, Hornshaw, M., additional, Nedergaard, J., additional, Ipsen, H., additional, Seyfarth, F., additional, Hipler, U.-C., additional, Schliemann, S., additional, Elsner, P., additional, Ausner, E., additional, Seelinger, M., additional, Matthias, J., additional, Kirsch, A. I., additional, Oberhofer, E., additional, Möhrenschlager, M., additional, Ring, J., additional, Menz, G., additional, Kespohl, S., additional, Förster, T., additional, Maryska, S., additional, Brüning, T., additional, Neumeister, V., additional, Nemat, K., additional, Hauswald, B., additional, Spornraft-Ragaller, P., additional, Blank, S., additional, Seismann, H., additional, Michel, Y., additional, McIntyre, M., additional, Cifuentes, L., additional, Braren, I., additional, Grunwald, T., additional, Darsow, U., additional, Bredehorst, R., additional, Ollert, M., additional, Spillner, E., additional, Christensen, L. H., additional, Amondsen, P., additional, Henmar, H., additional, Bergmann, K., additional, Schmidt, A., additional, Staatz, A., additional, Strohner, P., additional, Becher, G., additional, Nährlich, L., additional, Rudloff, S., additional, Steiß, J.-O., additional, Lange, L., additional, Sonntag, H., additional, Buderus, S., additional, Wahl, R., additional, Kraus, R., additional, Urbanek, R., additional, Grychtol, R., additional, Meinicke, H., additional, Müller, C., additional, Heinzmann, A., additional, Schiller, D., additional, Kühne, Y., additional, Becker, S., additional, Ballmer-Weber, B., additional, Niggemann, B., additional, Scibilia, J., additional, Bindslev-Jensen, C., additional, Wackermann, O., additional, Reese, G., additional, Vieths, S., additional, Holzhauser, T., additional, Gröger, M., additional, Canis, M., additional, Kramer, M., additional, Beck, I., additional, Jochner, S., additional, Gilles, S., additional, Schmidt-Weber, C., additional, Menzel, A., additional, Behrendt, H., additional, Traidl-Hoffmann, C., additional, Waßmann, A., additional, Wichmann, K., additional, Heratizadeh, A., additional, Wedi, B., additional, Kapp, A., additional, and Werfel, T., additional

Published
2011
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39. 21. Mainzer Allergie-Workshop

Author

Rennert, S., primary, Krause, S., additional, Becker, W., additional, Petersen, A., additional, Schocker, F., additional, Papenfuß, K., additional, Jappe, U., additional, Brehler, R., additional, Lange, L., additional, Riffelmann, F., additional, Nemat, K., additional, Hompes, S., additional, Holzhauser, T., additional, Lidholm, J., additional, Reese, G., additional, Vieths, S., additional, Seismann, H., additional, Blank, S., additional, Braren, I., additional, Greunke, K., additional, Cifuentes, L., additional, Grunwald, T., additional, Bredehorst, R., additional, Ollert, M., additional, Spillner, E., additional, von der Gathen, Y., additional, Sander, I., additional, Flagge, A., additional, Brüning, T., additional, Raulf-Heimsoth, M., additional, Zahradnik, E., additional, Fleischer, C., additional, Schierl, R., additional, Sültz, J., additional, Nowak, D., additional, Buters, J., additional, Weichenmeier, I., additional, Ochs, S., additional, Kreyling, W., additional, Boere, A., additional, Schober, W., additional, Behrendt, H., additional, Jaeger, T., additional, Kerzl, R., additional, Huss-Marp, J., additional, Ring, J., additional, Darsow, U., additional, Roeschmann, K., additional, Vroling, A., additional, van Drunen, C., additional, Ulmer, A., additional, Gilles, S., additional, Mariani, V., additional, Zhang, X., additional, Jakob, T., additional, Müller, M., additional, Pastore, S., additional, Traidl-Hoffmann, C., additional, Oeder, S., additional, Dietrich, S., additional, Fromme, H., additional, Schäfer, V., additional, Renne, J., additional, Werfel, T., additional, Wittmann, M., additional, Grusser, M., additional, Maurer, M., additional, Dudeck, A., additional, Suender, C., additional, Heydrich, S., additional, Bros, M., additional, Wiechmann, N., additional, Besche, V., additional, Hövelmeyer, N., additional, Reissig, S., additional, Massoumi, R., additional, Grabbe, S., additional, Waisman, A., additional, Reske-Kunz, A., additional, Gschwandtner, M., additional, Roßbach, K., additional, Bäumer, W., additional, Kietzmann, M., additional, Dijkstra, D., additional, Stark, H., additional, Gutzmer, R., additional, Höhn, Y., additional, Thamsen, M., additional, Trojandt, S., additional, Bovensiepen, C., additional, Bellinghausen, I., additional, Hilmenyuk, T., additional, Saloga, J., additional, Luxemburger, U., additional, Türeci, Ö., additional, Wiesner, H., additional, Kohlrautz, V., additional, Wahn, U., additional, Stock, P., additional, Mommert, S., additional, Köther, G., additional, Sudowe, S., additional, Barwig, C., additional, Montermann, E., additional, Milovanovic, M., additional, Koch, C., additional, Hilt, K., additional, Hartmann, B., additional, Heine, G., additional, Worm, M., additional, Ambach, A., additional, Hoefeld-Fegeler, M., additional, Besser, C., additional, Weren, A., additional, Schraven, B., additional, Bonekoh, B., additional, Gollnick, H., additional, Raap, M., additional, Bruder, M., additional, Kapp, A., additional, Raap, U., additional, Grosber, M., additional, Hausteiner, C., additional, Bubel, E., additional, Groben, S., additional, Bornschein, S., additional, Lahmann, C., additional, Zilker, T., additional, Eberlein, B., additional, Henningsen, P., additional, Huber, D., additional, Biedermann, T., additional, Kunz, J., additional, Fischer, J., additional, Kempf, W., additional, Wölbing, F., additional, Alexopoulou, A., additional, Albert, A., additional, Pfaar, O., additional, Distler, A., additional, Hörmann, K., additional, Klimek, L., additional, Wieczorek, D., additional, Büsing, M., additional, Wedi, B., additional, Rerinck, H.-C., additional, Przybilla, B., additional, Ruëff, F., additional, Weigert, C., additional, Ghoreschi, K., additional, Röcken, M., additional, Muhr, P., additional, Zeitvogel, J., additional, Ott, H., additional, Wiederholt, T., additional, Andresen-Bergström, M., additional, Skazik, C., additional, Merk, H., additional, Karlberg, A., additional, Zwadlo-Klarwasser, G., additional, Baron, J., additional, Frankenberg, U., additional, Lorenz, N., additional, Steinbrink, K., additional, Pföhler, C., additional, Dietrich, K.-A., additional, Thomas, P., additional, Baran, W., additional, Hänsel, A., additional, Meurer, M., additional, Schäkel, K., additional, Mamerow, D., additional, Niebuhr, M., additional, Bonnekoh, B., additional, Bunselmeyer, B., additional, Laubach, H., additional, Schiller, M., additional, Stanke, M., additional, Luger, T., additional, Böcking, C., additional, Köllisch, G., additional, Pfefferle, P., additional, Renz, H., additional, Conrad, M., additional, Teich, R., additional, Ferstl, R., additional, Brand, S., additional, Yildirim, A., additional, Kirschning, C., additional, Garn, H., additional, Eilbacher, I., additional, Stein, K., additional, Hanuszkiewicz, A., additional, Holst, O., additional, Heine, H., additional, Guenova, E., additional, Hoetzenecker, W., additional, Mailhammer, R., additional, Weindl, G., additional, Sauer, K., additional, Schaller, M., additional, Hiller, J., additional, Förster, S., additional, Eyerich, K., additional, Hofmann, H., additional, Ilchmann, A., additional, Burgdorf, S., additional, Waibler, Z., additional, Kurts, C., additional, Scheurer, S., additional, Kalinke, U., additional, Toda, M., additional, Adler, H. S., additional, Hofmann, C., additional, Becker, C., additional, Hemmer, W., additional, Focke, M., additional, Marzban, G., additional, Mayer, D., additional, Laimer, M., additional, Jarisch, R., additional, McIntyre, M., additional, Thiebes, V., additional, Mempel, M., additional, Jeßberger, B., additional, Vrtala, S., additional, Mauss, V., additional, Eben, R., additional, Walker, A. I., additional, Herzinger, T., additional, Berking, C., additional, Reese, I., additional, Sonar, S., additional, Ehmke, M., additional, Dietze, J., additional, Nockher, W., additional, Reuter, S., additional, Dehzad, N., additional, Martin, H., additional, Jung, M., additional, Heinz, A., additional, Stassen, M., additional, Buhl, R., additional, Taube, C., additional, Lingner, S., additional, Hennig, C., additional, Remke, J., additional, Hansen, G., additional, Dittrich, A., additional, Peters, M., additional, Bufe, A., additional, Polte, T., additional, Schütze, N., additional, Simon, J., additional, Lehmann, I., additional, Albrecht, M., additional, Preston-Hurlburt, P., additional, Bottomoly, H., additional, Pilzner, C., additional, Bühling, F., additional, Reinheckel, T., additional, Lauenstein, H., additional, Braun, A., additional, Welte, T., additional, Groneberg, D., additional, Greiner, T., additional, Zimmer, A., additional, Abram, M., additional, Fokuhl, V., additional, Luger, E., additional, Radbruch, A., additional, Zemlin, M., additional, Kilic, A., additional, Yildirim, A. Ö., additional, Alrifai, M., additional, Hagner, S., additional, Renzing, A., additional, Closs, E., additional, Bopp, T., additional, Schmitt, E., additional, Dicke, T., additional, Seyfarth, F., additional, Hipler, U., additional, Elsner, P., additional, Schliemann, S., additional, Konakovsky, V., additional, Moser, P., additional, Wantke, F., additional, Sesztak-Greinecker, G., additional, Götz, M., additional, Schmid, R., additional, and Hoffmann-Sommergruber, K., additional

Published
2009
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41. Nahrungsmittelallergene

Author

Reuter, F., primary, Bade, S., additional, Hirst, T., additional, Becker, W., additional, Frey, A., additional, Adler, H. S., additional, Hofmann, C., additional, Christ, S., additional, Raps, C., additional, Scheurer, S., additional, Vieths, S., additional, Steinbrink, K., additional, Krüger, U., additional, Buhl, T., additional, Hänßle, H., additional, Fuchs, T., additional, Süß, A., additional, Treudler, R., additional, Averbeck, M., additional, Simon, J., additional, Gorris, H., additional, McIntyre, M., additional, Mohammad-Gholiei, M., additional, Eberlein, B., additional, Ollert, M., additional, Ring, J., additional, Darsow, U., additional, Dölle, S., additional, Schwarz, D., additional, Lehmann, K., additional, Bäßler, O., additional, Franken, P., additional, George, E., additional, Worm, M., additional, Stratmann, C., additional, Fölster-Holst, R., additional, Kühne, Y., additional, Ballmer-Weber, B., additional, Niggemann, B., additional, Scibilia, J., additional, Reese, G., additional, Holzhauser, T., additional, Lorenz, Y., additional, Le Quynh, L., additional, Mahler, V., additional, Foetisch, K., additional, Enrique, E., additional, Bartra, J., additional, and Biemelt, S., additional

Published
2007
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43. Neue Deklarationspflicht für Nahrungsmittelallergene in Lebensmitteln

Author

Vieths, S., primary, Holzhauser, T., additional, Erdmann, S., additional, Fuchs, T., additional, Henzgen, M., additional, Kleine-Tebbe, J., additional, Lepp, U., additional, Niggemann, B., additional, Raithel, M., additional, Reese, I., additional, Saloga, J., additional, Vieluf, I., additional, Zuberbier, T., additional, and Werfel, T., additional

Published
2006
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47. The Development of the Boeing Human Model

Author

Underwood, R. C., Hilby, D. L., Holzhauser, T. B., and Tedlund, B. E.

Abstract

This paper summarizes the methodology and lessons learned in the development of the Boeing Human Model. In our efforts to implement human modeling with Computer Aided Design at Boeing Commercial Airplane Group (BCAG) several externally-developed programs were reviewed. Each system had unique strengths, but none satisfied our requirements for broad utilization. A human modeling program was developed internally which complied with a set of application-oriented development guidelines. Compliance with these guidelines during development led to a high level of utilization by engineering users. The cost of broadly implementing the model, however, was increased development time. Additional functions, such as strength modeling and animation, are required by our users. To accelerate the development of additional functions we may obtain support from other software development sources. Full understanding of our development guidelines will help ensure that additional functions can be fully integrated into our routine engineering operations.

Published
1991
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49. Validation of ELISA methods for quantification of the major birch allergen Bet v 1 (BSP090)

Author

Kaul, S., Zimmer, J., Dehus, O., Constanzo, A., Daas, A., Buchheit, K. -H, Asturias, J., Arilla, M. C., Barber, D., Bertocchi, A., Brunetto, B., Carnes, J. A., Chapman, M., Chaudemanche, G., Dayan-Kenigsberg, J., Döring, S., Führer, F., Gallego, M. T., Iacovacci, P., Hanschmann, K. M., Holzhauser, T., Hrabina, M., Ledesma, A., Moingeon, P., Nony, E., Pini, C., Plunkett, G., Raulf, M., Reese, G., Sandberg, E., Ingrid Sander, Smith, B., Strecker, D., Valerio, C., Ree, R., Weber, B., and Vieths, S.

Subjects
Europe, Quality Control, Biological Products, Humans, Reproducibility of Results, Enzyme-Linked Immunosorbent Assay, Allergens, Antigens, Plant, Reference Standards, Plant Proteins
Abstract

To date, the potency of allergen products in Europe is expressed in manufacturer-specific units relative to a product-specific in-house reference. Consequently, cross-product comparability of allergen products from different manufacturers with respect to strength and efficacy is impossible. The Biological Standardisation Programme (BSP) project BSP090 addresses this issue via the establishment of reference standards in conjunction with ELISA methods for the quantification of major allergens in allergen products. Since the initiation of BSP090, the recombinant major allergen Bet v 1 has been adopted by the European Pharmacopoeia Commission as a Chemical Reference Substance (CRS). In parallel, two sandwich ELISA systems for quantification of Bet v 1 were found suitable in preliminary phases of BSP090 to be validated in a large collaborative study. In this study, the candidate ELISA systems were compared with respect to accuracy, precision and variability. Thirteen participating laboratories tested model samples containing the CRS as well as spiked and unspiked birch pollen extracts. Both in pre-testing and in the collaborative study, the 2 candidate ELISA systems confirmed their suitability to quantify recombinant and native Bet v 1. As no clear-cut decision for one of the ELISA systems could be made based on the results of the collaborative study, a post-study testing was performed. Bet v 1 content of 30 birch pollen allergen products was determined in parallel in both ELISA systems. Consequently, 1 candidate ELISA system was selected to be proposed as the future European Pharmacopoeia standard method for Bet v 1 quantification.

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