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1. Ligamentum Teres Transfer During Medial Open Reduction in Patients with Developmental Dysplasia of the Hip.

Author

Paez, Conner, Badrinath, Raghav, Holt, Joshua, Bomar, James D, Mubarak, Scott J, Upasani, Vidyadhar V, and Wenger, Dennis R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pain Research, Clinical Research, Chronic Pain, Digestive Diseases, Developmental Dysplasia of the Hip, Hip Dislocation, Congenital, Hip Joint, Humans, Infant, Retrospective Studies, Round Ligaments, Treatment Outcome, ddh, developmental dysplasia of the hip, ligamentum teres reconstruction, ligamentum teres transfer, medial open reduction
Abstract

BackgroundThe ligamentum teres (LT) is believed to have a number of functions, including a role in hip stability, nociception, proprioception, vascular supply to the femoral head, and synovial fluid circulation. The LT is often excised in the process of performing a medial open reduction (MOR) of the hip. We sought to conduct a retrospective review of hips undergoing a MOR for dislocated infantile developmental dysplasia of the hip (DDH) to compare clinical and radiographic outcomes for patients with and without LT reconstruction.MethodsWe performed a retrospective review of 38 hips treated with MOR with or without LT reconstruction with minimum two-year follow-up. Radiographic outcomes were determined using the Severin score. Information regarding avascular necrosis (AVN), concomitant surgical procedures, repeat dislocation, subsequent surgery, limp, pain, and range of motion symmetry was recorded.ResultsEighteen hips that underwent MOR with LT reconstruction were compared to 20 hips that underwent MOR without LT reconstruction. Mean follow up for this cohort was 70.1 months (median: 61.8; Range: 24.2 to 182.2 months). The group with LT reconstruction had an 11% rate of AVN, the group without LT reconstruction had a 15% rate of AVN (p=1.0) No hips in either group re-dislocated or had pain at final follow up. Two hips (5%) had a limp at most recent follow up, all were in the group that did not receive a LT reconstruction (p=0.488). Three hips (17%) in the LT reconstruction group and one hip (5%) in the other group had asymmetrical hip range of motion at final follow up (p=0.328).ConclusionThis study offers preliminary data to suggest that ligamentum teres reconstruction is a safe procedure that can minimize the risk for subluxation or re-dislocation that can occur within the post reduction hip spica cast. Although in this study, the patients who did not have LT reconstruction had a similar re-dislocation rate, we believe that ligamentum teres preservation is a useful adjunct to medial open reduction, especially in centers that may only treat occasional cases or have less experience in applying an excellent hip spica cast.Level of Evidence: III.

Published
2021

17. Delayed Onset Post-Operative Neurologic Deficit in a Patient With Mucopolysaccharidosis type VI: A Case Report

Author

Lindsay, Christopher, Holt, Joshua, and Weinstein, Stuart

Subjects
Pediatrics
Abstract

BACKGROUND: Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by abnormal deposition of glycosaminoglycans (GAGs) in tissues. In type VI MPS, otherwise known as Maroteaux-Lamy syndrome, the defect is in the enzyme N-acetylgalactosamine-4-sulfatase. Thoracolumbar kyphosis results from GAG deposition, leading to incompetence of posterior ligamentous structures as well as poor trunk control. Though neurologic symptoms from canal compression due to deformity and hypertrophy of tissues have been described, occasionally requiring surgical decompression, there has not been a prior report of late onset of symptoms in a previously neurologically intact patient following surgery to correct spine deformity. METHODS: The case reviewed is a 14 year old girl with mucopolysaccharidosis type VI underwent anterior release and posterior instrumentation for correction of severe progressive lumbar kyphosis. Postoperatively she developed delayed onset of profound lower extremity weakness and underwent urgent wide laminectomies and resection of thickened ligamentum flavum. At 1 year follow-up, she had near complete neurologic recovery. CONCLUSION: Patients with mucopolysacchari-doses are at significant risk for neurologic compromise both as part of the natural history of the disease, and as a risk of deformity correction. The surgeon must consider the pathologic thickening of tissues surrounding the spinal cord when planning surgery. Level of Evidence: IV

Published
2022

20. Optimisation of the Americium and Plutonium Purification by Extraction (AMPPEX) Process Flowsheet

Author

Sanderson, Rebecca, primary, Sarsfield, Mark, additional, Maher, Chris, additional, Carrott, Michael, additional, Whittaker, Dan, additional, Keywood, Billy, additional, Mason, Chris, additional, Jackson, Kerry, additional, Edmondson, Chloe, additional, Needham, Catherine, additional, Holt, Joshua, additional, Borwick, Jason, additional, and Stephenson, Keith, additional

Published
2022
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23. The international law exception to the act of state doctrine: redressing human rights abuses in Papua New Guinea.

Author

Holt, Joshua Gregory

Subjects
Jus cogens (International law) -- Laws, regulations and rules, Human rights -- Laws, regulations and rules, Federal jurisdiction -- Laws, regulations and rules, Separation of powers -- Laws, regulations and rules, Sarei v. Rio Tinto PLC 456 F.3d 1069 (9th Cir. 2006) (456 F.3d 1069 (9th Cir. 2006)), Government regulation, Alien Tort Statute
Abstract

Abstract: In Sarei v. Rio Tinto, the Ninth Circuit reversed the dismissal of Papua New Guinea residents' alleged human rights violations and environmental tort claims under customary international law and [...]

Published
2007

29. Comparison of Radiation Effects in Custom and Commercially Fabricated Resistive Memory Devices

Author

Holt, Joshua S., primary, Alamgir, Zahiruddin, additional, Beckmann, Karsten, additional, Suguitan, Nadia, additional, Russell, Sierra, additional, Iler, Evan, additional, Bakhru, Hassaram, additional, Bielejec, Edward S., additional, Jacobs-Gedrim, Robin B., additional, Hughart, David R., additional, Marinella, Matthew J., additional, Yang-Scharlotta, Jean, additional, and Cady, Nathaniel C., additional

Published
2019
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31. List of Contributors

Author

Abtahi, Ali R., Adogwa, Owoicho, Ahmed, A. Karim, Ainechi, Ana, Alan, Nima, Albanese, Jessica, Aleem, Ilyas, Almeida, Joao Paulo, Alshabab, Basel Sheikh, Alvarado, Anthony M., Alvi, Mohammed Ali, Amer, Aboubakr, Ames, Christopher P., Ammanuel, Simon G., Anand, Neel, Anderson, Paul A., Angelov, Lilyana, Arnold, Paul M., Aubin, Carl-Eric, Bae, Junseok, Bain, Mark, Barber, Joshua, Baron, Eli M., Basi, Hersimren Kaur, Bawahab, Asef, Benzel, Edward C., Berven, Sigurd H., Bevan, Adam K., Bice, Miranda, Bilsky, Mark, Bisson, Erica F., Blaskiewicz, Donald, Boody, Barrett S., Bowles, Daniel, Branch, Charles, Brooks, Nathaniel, Buckland, Aaron J., Buell, Thomas J., Burch, Shane, Burke, John F., Butt, Bilal B., Bydon, Mohamad, Camara, Joaquin, Canseco, Jose A., Casper, David S., Cassidy, Matthew, Chao, Samuel T., Chatain, Grégoire P., Chieng, Lee Onn, Cho, Woojin, Choi, Hoon, Christopher, Susan R., Chung, Andrew S., Clark, Aaron J., Coric, Domagoj, Corriveau, Mark D., Cottrill, Ethan, Cychosz, Christopher, Daubs, Gregory, Daubs, Michael D., Davin, Sara, DeMicco, Russell C., de Padua, Ashley, Derman, Peter B., Dhall, Sanjay S., Diab, Mohammad, DiGiorgio, Anthony M., Dimar, John R., II, Dru, Alexander B., Dubousset, Jean, Dunbar, Melissa R., Ebrahim, Zeyd, Ehresman, Jeff, Elder, J. Bradley, Ellenbogen, Richard G., El Naga, Ashraf N., Emans, John B., Engstrom, John W., Errico, Thomas J., Farag, Ehab, Farber, S. Harrison, Fatima, Nida, Fedorak, Graham T., Fehlings, Michael G., Feigenbaum, Frank, Ferrara, Lisa, Fessler, Richard G., Finn, Michael, Fischgrund, Jeffrey S., Fisher, Mark D., Fontes, Ricardo B.V., Fox, Michael A., Freedman, Brett A., Frenkel, Mark, Fridley, Jared, Gabet, Joelle, Garg, Sumeet, German, John W., Ghogawala, Zoher, Gibbs, Christopher M., Gillick, John L., Gilligan, Christopher J., Gillis, Christopher C., Goel, Atul, Gokaslan, Ziya L., Goldstein, Zachary H., Grant, Gerald A., Grasso, Mackenzie, Grossbach, Andrew J., Guan, Jian, Guinn, Jeremy, Gupta, Raghav, Gussous, Yazeed M., Guyer, Richard D., Haddad, Alexander F., Hamilton, Kirsty, Harland, Tessa, Harrop, James S., Hart, David J., Hart, Robert A., Hassan, Waqaas A., Hayes, Amanda W., Heary, Robert F., Hedequist, Daniel, Henderson, Fraser C., Sr., Henzel, M. Kristi, Herring, Eric Z., Higgins, Dominique, Hilibrand, Alan S., Hindoyan, Kevork N., Hines, Kevin, Hitchon, Patrick W., Hoffmann, Jacob C., Hoh, Daniel J., Holt, Joshua, Hsia, Augusto, Hsieh, Jason, Hsu, Wellington K., Hurlbert, John, Hwang, Steven W., Iordanou, Jordan C., Jack, Andrew S., Janich, Karl, Jiang, Bowen, Jiang, Fan, Jimenez, Xavier F., Johnson, J. Patrick, Jones, G. Alexander, Jones, Kristen E., Joseph, Jacob R., Joshi, Rushikesh S., Juthani, Rupa G., Kalfas, Iain H., Kalra, Ricky R., Kang, James D., Kanter, Adam S., Kasliwal, Manish K., Kaushal, Mayank, Kerolus, Mena G., Kesler, Kyle, Kessler, Remi A., Khalaf, Tagreed, Khalil, Jad G., Kim, Terrence T., Kimball, Jon, Kisinde, Stanley, Klineberg, Eric O., Kondylis, Efstathios, Kramer, Dallas E., Krauss, William E., Krishnaney, Ajit A., Krogue, Justin, Kshettry, Varun R., Kumar, Neeraj, Kurpad, Shekar N., Labak, Collin M., Labelle, Hubert, Ladd, Bryan, Lafage, Virginie, Laratta, Joseph L., Lark, Robert, Lau, Darryl, Laufer, Ilya, Lavelle, William F., Le, Hai V., Lee, Andrew, Lee, Nathan J., Lee, Sang-Ho, Lehman, Ronald A., Jr., Lehner, Kurt, Lenke, Lawrence G., Li, Yingda, Lieberman, Isador H., Ling, Marcus Z., Lo, Victor P., Lollis, S. Scott, Lombardi, Joseph M., Long, Donlin, Long, Roger, Lotz, Jeffrey, Lyons, Joseph G., Mac-Thiong, Jean-Marc, Machado, Andre, Mallow, Gary M., Malone, David G., Manjila, Sunil, Maroon, Joseph C., Maslak, Joseph P., Massaad, Elie, Matsumoto, Morio, Martini, Michael L., Mayer, E. Kano, Mayer, Rory, Mazanec, Daniel J., McCormick, Kyle L., McCormick, Paul C., McGrath, Kyle, McNeill, Ian T., Medress, Zachary A., Mendelis, Joseph R., Mendis, Phillip G., Metz, Lionel, Midha, Rajiv, Miele, Vincent J., Mijatovic, Desimir, Mikula, Anthony L., Min, Elliot, Mizuno, Shuichi, Moghaddamjou, Ali, Molenda, Joseph E., Momin, Arbaz, Momin, Eric, Moore, Nina Z., Morris, Dylan, Morrissette, Cole R., Mroz, Thomas E., Mummaneni, Praveen V., Mundis, Gregory M., Munoz, Tess, Naderi, Sait, Nagel, Sean J., Nagoshi, Narihito, Nail, Tara Jayde, Nair, Dileep, NaPier, Zachary, Neifert, Sean N., Nemunaitis, Gregory, Nessim, Adam, Niu, Tianyi, Norwig, John A., Ong, Binnan, Onwuzulike, Kaine C., Oren, Jonathan, Orr, R. Douglas, O’Toole, John E., Ozpinar, Alp, Padua, Fortunato G., Page, Paul, Park, Paul J., Parmar, Vikas, Patel, Arati, Patel, Parthik, Patel, Rakesh, Pelle, Dominic, Peña, Enrique, Pendleton, Courtney, Pennicooke, Brenton, Pennington, Zach, Perez-Cruet, Mick J., Petersen-Fitts, Graysen R., Peterson, Thomas A., Piche, Joshua, Placide, Rick, Platt, Andrew, Polifka, Adam J., Polly, David W., Poree, Lawrence, Rajasekaran, S., Rammo, Richard, Rasouli, Jonathan J., Ratliff, John K., Rawlinson, Jeremy J., Ray, Wilson Z., Recinos, Pablo F., Recinos, Violette M., Reid, Patrick, Renfrow, Jackie, Resnick, Daniel K., Resser, Tina, Rhines, Laurence D., Richardson, Dusty, Riesenburger, Ron, Rispinto, Sarah, Rivera, Joshua, Rosenquist, Richard Wayne, Ross, Lindsey, Rossi, Vincent, Rudisill, Samuel S., Ruggieri, Paul, Ryu, Won Hyung A., Sabourin, Victor, Safaee, Michael M., Safain, Mina, Salaheen, Zaid, Samartzis, Dino, Samdani, Amer F., Samtani, Rahul G., Sasso, Rick, Satin, Alexander M., Savage, Jason W., Sawin, Paul D., Sawires, Andrew N., Sawyer, Aenor, Schmidt, Bradley T., Schmidt, Eric, Schmidt, Meic H., Schwab, Frank J., Sciubba, Daniel M., Sellin, Jonathan N., Shaaya, Elias, Shabani, Saman, Shaffrey, Christopher I., Shankar, Ganesh M., Shao, Jianning, Sharan, Alok D., Shaw, Jeremy D., Shen, Jian, Shenoy, Kartik, Shetty, Ajoy Prasad, Shin, John H., Shook, Steven J., Singh, Harminder, Singh, Rahul, Sissman, Ethan, Siyaji, Zakariah K., Smith, Gabriel A., Smith, John T., Smith, Justin S., Spinner, Robert J., Spurgas, Morgan P., Stefanelli, Anthony J., Steinmetz, Michael P., Sundar, Swetha J., Swarup, Ishaan, Takeoka, Yoshiki, Tatsui, Claudio E., Teferi, Nahom, Telfeian, Albert E., Theodore, Nicholas, Theologis, Alekos A., Thiyagarajah, Nishanth, Thorp, Brian D., Traynelis, Vincent C., Trost, Gregory R., Truong, Huy Q., Tsiang, John T., Tumialán, Luis M., Tymchak, Zane A., Udayasankar, Unni, Umansky, Daniel, Uribe, Juan S., Vaccaro, Alexander R., Vargovich, Alison M., Vaziri, Sasha, Veeravagu, Anand, Venezia, Michael, Verma, Kushagra, Vilarello, Brandon, Viljoen, Stephanus V., Viswanathan, Vibhu Krishnan, Volovetz, Josephine, Vorster, Sarel J., Walker, Corey T., Wallace, Daniel J., Wang, Anthony C., Wang, Jeffrey C., Wang, Marjorie C., Wang, Michael Y., Wang, Xiaoyu, Weinstein, Stuart L., Weisman, Michael H., Weissmann, Karen, Wentworth, Kelly, Whiting, Benjamin, Whitmore, Robert G., Wick, Joseph, Williams, Michelle, Wilson, James R., Wilson, Leslie, Witham, Timothy, Wolfla, Christopher E., Wolinsky, Jean-Paul, Woodard, Eric J., Wu, Hao-Hua, Yang, Michael, Yezdani, Samir G., Yoganandan, Narayan, Yolcu, Yagiz, Young, Robin, Zanation, Adam, Zehri, Aqib, and Zileli, Mehmet

Published
2022
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32. kHz dye laser for use with ultrafast laser systems

Author

Schumacher, Douglass, Marshall, Owen, Holt, Joshua, Bajema, Michael L., van Leeuwen, Robert, and Gallagher, Thomas F.

Subjects
Optics -- Usage, Lasers -- Design and construction, Astronomy, Physics
Abstract

We have constructed a cavity-dumped dye laser optimized for use with kHz repetition rate ultrafast lasers for performing experiments on atomic and molecular systems. The dye laser is inexpensive, robust, and requires little pump energy, making it ideal for experiments requiring multiple excitations for state preparation. OCIS codes: 140.2050, 140.3600, 140.7090.

Published
2002

41. Progressive Elbow Magnetic Resonance Imaging Abnormalities in Little League Baseball Players Are Common: A 3-Year Longitudinal Evaluation.

Author

Holt, Joshua B., Pedowitz, Jason M., Stearns, Philip H., Bastrom, Tracey P., Dennis, M. Morgan, Dwek, Jerry R., and Pennock, Andrew T.

Subjects
*ANALYSIS of variance, *ARM, *ATHLETES, *BASEBALL, *COMPARATIVE studies, *STATISTICAL correlation, *ELBOW, *LONGITUDINAL method, *MAGNETIC resonance imaging, *MEDICAL history taking, *PAIN, *PEDIATRICS, *PHYSICAL diagnosis, *SURGICAL plaster casts, *SPORTS medicine, *STATISTICS, *DATA analysis, *MULTIPLE regression analysis, *QUANTITATIVE research, *SPORTS participation, *THROWING (Sports), *REPEATED measures design, *DATA analysis software, *DESCRIPTIVE statistics, *ODDS ratio
Abstract

Background: Prior studies have revealed magnetic resonance imaging (MRI) evidence of elbow pathology in single-season evaluation of competitive youth baseball players. The natural history of these findings and risk factors for progression have not been reported. Purpose: To characterize the natural history of bilateral elbow MRI findings in a 3-year longitudinal study and to correlate abnormalities with prior MRI findings, throwing history, playing status, and physical examination. Study Design: Cohort study; Level of evidence, 2. Methods: A prospective study of Little League players aged 12 to 15 years was performed. All players had preseason and postseason bilateral elbow MRI performed 3 years before this study. Players underwent repeat bilateral elbow MRI, physical examination, and detailed assessment of throwing history, playing status, and arm pain. Imaging was read by a blinded musculoskeletal radiologist and compared with prior MR images to assess for progression or resolution of previously identified pathology. Results: All 26 players who participated in the previous single-season study returned for a 3-year assessment. At the completion of the study, 15 players (58%) had dominant arm MRI pathology. Eighty percent (12/15 players) of MRI findings were new or progressive lesions. Players with postseason MRI pathology at the beginning of the study were more likely to have MRI pathology at the 3-year follow-up than players with previously normal postseason MRI (P <.05), although 6 of the 14 players (43%) with previously normal MRI developed new pathology. Year-round play was a significant predictor of tenderness to elbow palpation (P =.027) and positive MRI findings at 3 years (P =.047). At the 3-year follow-up, 7 players (27%) reported having throwing elbow pain and 3 had required casting. Additionally, differences were noted in the dominant arm's internal and external rotation in those that continued to play baseball (P <.05). Conclusion: Dominant elbow MRI abnormalities are common in competitive Little League Baseball players. Year-round play imparts significant risk for progression of MRI pathology and physical examination abnormalities. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Decreasing Bacterial Colonization of External Fixation Pins Through Nitric Oxide Release Coatings

Author

Schoenfisch, Mark, Holt, Joshua, Weinhold, Paul, Hertzberg, Brian, Storm, Wesley, and Dahners, Laurence

Abstract

Bacterial infection of the pin tract represents the most common complication associated with external fixation. This study was designed to evaluate the antibacterial activity of nitric oxide (NO) releasing xerogel films applied to commercially pure titanium pins in a rat model.

Published
2011
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47. Pulse width and height modulation for multi-level resistance in bi-layer TaOx based RRAM.

Author

Alamgir, Zahiruddin, Beckmann, Karsten, Holt, Joshua, and Cady, Nathaniel C.

Subjects
TANTALUM oxide, NEUROMORPHICS, COGNITIVE computing, RANDOM access memory, CURVE fitting
Abstract

Mutli-level switching in resistive memory devices enables a wide range of computational paradigms, including neuromorphic and cognitive computing. To this end, we have developed a bilayer tantalum oxide based resistive random access memory device using Hf as the oxygen exchange layer. Multiple, discrete resistance levels were achieved by modulating the RESET pulse width and height, ranging from 2 k⃾ to several M⃾. For a fixed pulse height, OFF state resistance was found to increase gradually with the increase in the pulse width, whereas for a fixed pulse width, the increase in the pulse height resulted in drastic changes in resistance. Resistive switching in these devices transitioned from Schottky emission in the OFF state to tunneling based conduction in the ON state, based on I-V curve fitting and temperature dependent current measurements. These devices also demonstrated endurance of more than 108 cycles with a satisfactory Roff/ Ron ratio and retention greater than 104 s. [ABSTRACT FROM AUTHOR]

Published
2017
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