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387 results on '"Holst, René"'

1. Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy

Author

Hjell, Gabriela, Rokicki, Jaroslav, Szabo, Attila, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Djurovic, Srdjan, Ueland, Thor, Andreassen, Ole Andreas, Melle, Ingrid, Lagerberg, Trine Vik, Mørch-Johnsen, Lynn, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2023
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6. SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people

Author

Garabet, Lamya, Eriksson, Anna, Tjønnfjord, Eirik, Cui, Xue-Yan, Olsen, Magnus Kringstad, Jacobsen, Hege Karine, Jørgensen, Camilla Tøvik, Mathisen, Åse-Berit, Mowinckel, Marie-Christine, Ahlen, Maria Therese, Sørvoll, Ingvild Hausberg, Horvei, Kjersti Daae, Ernstsen, Siw Leiknes, Lægreid, Ingvild Jenssen, Stavik, Benedicte, Holst, René, Sandset, Per Morten, and Ghanima, Waleed

Published
2023
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8. Interleukin-18 signaling system links to agitation in severe mental disorders

Author

Hjell, Gabriela, Szabo, Attila, Mørch-Johnsen, Lynn, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Dieset, Ingrid, Djurovic, Srdjan, Melle, Ingrid, Ueland, Thor, Andreassen, Ole Andreas, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2022
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13. Efficient and Robust Estimation for a Class of Generalized Linear Longitudinal Mixed Models

Author

Holst, René and Jørgensen, Bent

Subjects
Statistics - Methodology, Statistics - Applications, 62E10, 60F99, 60E10 (Primary) 62E20, 62N99 (Secondary)
Abstract

We propose a versatile and computationally efficient estimating equation method for a class of hierarchical multiplicative generalized linear mixed models with additive dispersion components, based on explicit modelling of the covariance structure. The class combines longitudinal and random effects models and retains a marginal as well as a conditional interpretation. The estimation procedure combines that of generalized estimating equations for the regression with residual maximum likelihood estimation for the association parameters. This avoids the multidimensional integral of the conventional generalized linear mixed models likelihood and allows an extension of the robust empirical sandwich estimator for use with both association and regression parameters. The method is applied to a set of otolith data, used for age determination of fish., Comment: 22 pages, 3 figures, IMADA preprint, uploaded 2010-08-17

Published
2010

23. SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people

Author

Garabet, Lamya, primary, Eriksson, Anna, additional, Tjønnfjord, Eirik, additional, Cui, Xue-Yan, additional, Olsen, Magnus Kringstad, additional, Jacobsen, Hege Karine, additional, Jørgensen, Camilla Tøvik, additional, Mathisen, Åse-Berit, additional, Mowinckel, Marie-Christine, additional, Ahlen, Maria Therese, additional, Sørvoll, Ingvild Hausberg, additional, Horvei, Kjersti Daae, additional, Ernstsen, Siw Leiknes, additional, Lægreid, Ingvild Jenssen, additional, Stavik, Benedicte, additional, Holst, René, additional, Sandset, Per Morten, additional, and Ghanima, Waleed, additional

Published
2022
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25. High-intensity interval training may reduce depressive symptoms in individuals with schizophrenia, putatively through improved VO2max: A randomized controlled trial

Author

Bang-Kittilsen, Gry, Engh, John Abel, Holst, René, Holmen, Tom Langerud, Bigseth, Therese Torgersen, Andersen, Eivind, Mordal, Jon, and Egeland, Jens

Subjects
Psychiatry and Mental health
Abstract

IntroductionHigh-intensity interval training (HIIT) may improve cardiorespiratory fitness (CRF) and mental health. The current observer-blinded RCT investigates the sparsely studied efficiency of HIIT in reducing psychotic and non-psychotic symptoms in schizophrenia and complements previous studies by investigating whether symptom reduction following HIIT is associated with, putatively partly mediated by, increased VO2max.MethodsParticipants (outpatients meeting diagnostic criteria for schizophrenia) were randomized to HIIT (n = 43) or a comparison group performing low-intensity active video gaming (AVG) to control for social interaction (n = 39). Both interventions consisted of two supervised sessions/week for 12 weeks and a 4 months follow-up. Effects on overall symptoms and symptom domains [PANSS (0–6 scale), five-factor model] were estimated using mixed-effects models (intention-to-treat, n = 82). Underlying mechanisms were analyzed using moderated mediation analyses (n = 66). We anticipated that HIIT would reduce overall symptoms, particularly depressive symptoms, more than AVG, and symptom reduction would be associated with, putatively mediated through, improved VO2max.ResultsDepressive symptoms (baseline score 3.97, 95% CI: 3.41, 4.52), were −1.03 points more reduced in HIIT than AVG at post-intervention (95% CI: −1.71, −0.35, p = 0.003), corresponding to a small to moderate effect size (d = 0.37) and persisting at follow-up. There was a small reduction in overall symptoms, but no significant between-group differences were observed. Change in VO2max correlated negatively with the change in depressive symptoms. Mediation analysis showed a significant effect of change in VO2max on change in depressive symptoms within HIIT. The total effect was moderated by group, and depressive symptoms were more reduced in HIIT. Direct effects, not mediated through VO2max, were non-significant. Indirect effects, mediated through VO2max, were non-significant, but the moderated mediation test indicated a non-significant trend of 0.4 points (95% CI: −1.188, 0.087) and a larger reduction in depressive symptoms through VO2max in HIIT.ConclusionHIIT reduced depressive symptoms more than AVG, which persisted at follow-up. HIIT may serve as a complementing treatment option targeting these symptoms in individuals with schizophrenia, even before they reach clinical depression. Depressive symptoms are important to prevent, stabilize, and treat due to their negative implications for psychological wellbeing and long-term functional outcome. Reduction in depressive symptoms was associated with improved VO2max, and non-significant trends in the data supported that improved VO2max may be part of the complex mechanisms underlying the anti-depressive effect of HIIT.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT02205684].

Published
2022

32. Statistical advising: Professional development opportunities for the biostatistician

Author

LeBlanc, Marissa, primary, Rueegg, Corina S., additional, Bekiroğlu, Nural, additional, Esterhuizen, Tonya M., additional, Fagerland, Morten W., additional, Falk, Ragnhild S., additional, Frøslie, Kathrine F., additional, Graf, Erika, additional, Heinze, Georg, additional, Held, Ulrike, additional, Holst, René, additional, Lange, Theis, additional, Mazumdar, Madhu, additional, Myrberg, Ida H., additional, Posch, Martin, additional, Sergeant, Jamie C., additional, Vach, Werner, additional, Vance, Eric A., additional, Weedon‐Fekjær, Harald, additional, and Zucknick, Manuela, additional

Published
2022
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37. High-intensity interval training may reduce depressive symptoms in individuals with schizophrenia, putatively through improved VO2max: A randomized controlled trial.

Author

Bang-Kittilsen, Gry, Engh, John Abel, Holst, René, Holmen, Tom Langerud, Bigseth, Therese Torgersen, Andersen, Eivind, Mordal, Jon, and Egeland, Jens

Subjects
HIGH-intensity interval training, MENTAL depression, RANDOMIZED controlled trials, PEOPLE with schizophrenia, EXERCISE video games
Abstract

Introduction: High-intensity interval training (HIIT) may improve cardiorespiratory fitness (CRF) and mental health. The current observerblinded RCT investigates the sparsely studied efficiency of HIIT in reducing psychotic and non-psychotic symptoms in schizophrenia and complements previous studies by investigating whether symptom reduction following HIIT is associated with, putatively partly mediated by, increased VO2max. Methods: Participants (outpatients meeting diagnostic criteria for schizophrenia) were randomized to HIIT (n = 43) or a comparison group performing low-intensity active video gaming (AVG) to control for social interaction (n = 39). Both interventions consisted of two supervised sessions/week for 12 weeks and a 4 months follow-up. Effects on overall symptoms and symptom domains [PANSS (0-6 scale), five-factor model] were estimated using mixed-effects models (intentionto-treat, n = 82). Underlying mechanisms were analyzed using moderated mediation analyses (n = 66). We anticipated that HIIT would reduce overall symptoms, particularly depressive symptoms, more than AVG, and symptom reduction would be associated with, putatively mediated through, improved VO2max. Results: Depressive symptoms (baseline score 3.97, 95% CI: 3.41, 4.52), were -1.03 points more reduced in HIIT than AVG at post-intervention (95% CI: -1.71, -0.35, p = 0.003), corresponding to a small to moderate effect size (d = 0.37) and persisting at follow-up. There was a small reduction in overall symptoms, but no significant between-group differences were observed. Change in VO2max correlated negatively with the change in depressive symptoms. Mediation analysis showed a significant effect of change in VO2max on change in depressive symptoms within HIIT. The total effect was moderated by group, and depressive symptoms were more reduced in HIIT. Direct effects, not mediated through VO2max, were non-significant. Indirect effects, mediated through VO2max, were non-significant, but the moderated mediation test indicated a non-significant trend of 0.4 points (95% CI: -1.188, 0.087) and a larger reduction in depressive symptoms through VO2max in HIIT. Conclusion: HIIT reduced depressive symptoms more than AVG, which persisted at follow-up. HIIT may serve as a complementing treatment option targeting these symptoms in individuals with schizophrenia, even before they reach clinical depression. Depressive symptoms are important to prevent, stabilize, and treat due to their negative implications for psychological wellbeing and long-term functional outcome. Reduction in depressive symptoms was associated with improved VO2max, and non-significant trends in the data supported that improved VO2max may be part of the complex mechanisms underlying the anti-depressive effect of HIIT. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Interleukin-1 Family Signaling Related to Agitation in Severe Mental Disorders

Author

Hjell, Gabriela, primary, Szabo, Attila, additional, Mørch-Johnsen, Lynn, additional, Holst, René, additional, Tesli, Natalia, additional, Bell, Christina, additional, Fisher-Vieler, Thomas, additional, Frogner Werner, Maren Caroline, additional, Lunding, Synve Hoffart, additional, Ormerod, Monica, additional, Dieset, Ingrid, additional, Djurovic, Srdjan, additional, Melle, Ingrid, additional, Ueland, Thor, additional, Andreassen, Ole Andreas, additional, Steen, Nils Eiel, additional, and Haukvik, Unn Kristin, additional

Published
2021
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41. Additional file 2 of Pulmonary rehabilitation to improve physical capacity, dyspnea, and quality of life following pulmonary embolism (the PeRehab study): study protocol for a two-center randomized controlled trial

Author

Haukeland-Parker, Stacey, Jervan, Øyvind, Johannessen, Hege Hølmo, Gleditsch, Jostein, Stavem, Knut, Steine, Kjetil, Spruit, Martijn A., Holst, René, Mazdak Tavoly, Klok, Frederikus A., and Ghanima, Waleed

Abstract

Additional file 2. Ethical approval for the project

Published
2021
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42. Additional file 1 of Exploring intervention components in association with changes in preschool children’s vegetable intake: the BRA-study

Author

Kristiansen, Anne Lene, Himberg-Sundet, Anne, Bjelland, Mona, Lien, Nanna, Holst, René, and Andersen, Lene Frost

Subjects
education
Abstract

Additional file 1: Figure S1. Estimated marginal means of the BRA-study, showing vegetables served in the kindergarten departments (n = 34) at baseline and follow-up 1, in relation to what degree the intervention components (posters, supplementary material and 1-day inspirational course) were perceived useful by the kindergarten staff. (Black box) Baseline data, (Orange dotted box) Follow-up 1 data.

Published
2021
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43. Additional file 1 of Pulmonary rehabilitation to improve physical capacity, dyspnea, and quality of life following pulmonary embolism (the PeRehab study): study protocol for a two-center randomized controlled trial

Author

Haukeland-Parker, Stacey, Jervan, Øyvind, Johannessen, Hege Hølmo, Gleditsch, Jostein, Stavem, Knut, Steine, Kjetil, Spruit, Martijn A., Holst, René, Mazdak Tavoly, Klok, Frederikus A., and Ghanima, Waleed

Abstract

Additional file 1. SPIRIT checklist

Published
2021
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44. Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4

Author

Sækmose, Susanne Gjørup, Holst, René, Lottenburger, Tine, Ytting, Henriette, Nielsen, Hans Jørgen, Junker, Peter, Schlosser, Anders, Sorensen, Grith Lykke, Sækmose, Susanne Gjørup, Holst, René, Lottenburger, Tine, Ytting, Henriette, Nielsen, Hans Jørgen, Junker, Peter, Schlosser, Anders, and Sorensen, Grith Lykke

Abstract

Serum microfibrillar-associated protein 4 (sMFAP4) has been investigated as a biomarker for various diseases and is demonstrated to show significant gradual increase with severity of liver fibrosis. Ideal biomarkers used for disease diagnosis or prognosis should display deviating levels in affected individuals only and be robust to factors unrelated to the disease. Here we show the impact of normal physiological variation of sMFAP4 by characterizing the circadian variation, week-to-week variation, and physical exercise-induced levels. Serum samples from 3 groups of healthy volunteers were drawn: 7 times during a 24-hour period, 5 times during a 3-week period, and before and after a standardized physical exercise challenge. sMFAP4 was determined by AlphaLISA. Statistical analysis was performed using mixed effects modeling of repeated measurements. Circadian variation of sMFAP4 was demonstrated, with time of peak and nadir values depending on age and gender. For males, the peak values were observed during nighttime whereas for females, peak values were observed in the morning. Individual sMFAP4 levels remained stable over a period of 3 weeks and physical exercise inferred a mild negative influence. In conclusion, the circadian sMFAP4 variation was significant, and the levels could be influenced by physical activity. However, these variations were of limited magnitude relative to previously observed disease-induced levels in support of the biomarker potential of sMFAP4.

Published
2021

45. Effects of prebiotics on postprandial GLP-1, GLP-2 and glucose regulation in patients with type 2 diabetes:A randomised, double-blind, placebo-controlled crossover trial

Author

Birkeland, Eline, Gharagozlian, Sedegheh, Gulseth, Hanne L, Birkeland, Kåre I, Hartmann, Bolette, Holst, Jens J, Holst, René, Aas, Anne-Marie, Birkeland, Eline, Gharagozlian, Sedegheh, Gulseth, Hanne L, Birkeland, Kåre I, Hartmann, Bolette, Holst, Jens J, Holst, René, and Aas, Anne-Marie

Abstract

AIMS: We aimed to investigate the effect of prebiotic inulin-type fructans versus a control supplement on postprandial levels of glucagon-like peptide-1 and -2 (GLP-1 and -2), glucose, and insulin in patients with type 2 diabetes.METHODS: Adult men and women with type 2 diabetes were randomised in a double-blind, placebo-controlled crossover study. The study participants received 16 g/d inulin-type fructans and 16 g/d control supplement (maltodextrin) for six weeks each in two phases separated by a four weeks washout. A standardised mixed meal test was performed before and after each intake period. The primary endpoint was changes in the GLP-1 response, and secondary endpoints were GLP-2, glucose and insulin responses. Data were analysed using mixed model analysis.RESULTS: A total of 29 participants were included in the study. Differences between and within the two treatments in estimated area under the curves were not significant. Yet, the predicted means for meal induced GLP-1 response in plasma showed a 4.8% decline after the prebiotic treatment and an 8.6% increase after the control treatment (difference in changes between the treatments, p < 0.001). Fasting or postprandial glucose, insulin or GLP-2 levels were not changed.CONCLUSIONS: Our findings do not support that inulin-type fructans improve incretin responses or glucose-regulations in this population.

Published
2021

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