14 results on '"Holmqvist, Anna S."'
Search Results
2. Disease-specific Hospitalizations Among 5-Year Survivors of Hepatoblastoma: A Nordic Population-based Cohort Study
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Bonnesen, Trine G., Asdahl, Peter H., de Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Holmqvist, Anna S., Madanat-Harjuoja, Laura-Maria, Tryggvadottir, Laufey, Winther, Jeanette F., and Hasle, and Henrik
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- 2019
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3. Person-centred online lifestyle coaching in childhood, adolescent, and young adult cancer survivors: protocol of the multicentre PanCareFollowUp lifestyle intervention feasibility study
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Bouwman, Eline, Hermens, Rosella P. M. G., Brown, Morven C., Araújo-Soares, Vera, Blijlevens, Nicole M. A., Kepak, Tomas, Kepakova, Katerina, Kremer, Leontien C. M., van den Oever, Selina R., van der Pal, Helena J. H., Skinner, Roderick, Pluijm, Saskia M. F., Loonen, Jacqueline J., Mulder, Renée L., van Kalsbeek, Rebecca J., Hjorth, Lars, Follin, Cecilia, Eriksson, Lill, Relander, Thomas, Engellau, Jacob, Fjordén, Karin, Bogefors, Karolina, Holmqvist, Anna S., Haupt, Riccardo, Muraca, Monica, Nicolas, Brigitte, Bagnasco, Francesca, Benvenuto, Marina, Aulicino, Anna, Laudisi, Luca, Hrstkova, Hana, Bajciova, Viera, Holikova, Marta, Strublova, Lucie, Uyttebroeck, Anne, Renard, Marleen, Jacobs, Sandra, Segers, Heidi, van Helvoirt, Monique, Winther, Jeanette F., Mader, Luzius, Frederiksen, Line E., Andersen, Elisabeth A. W., Michel, Gisela, Boes, Stefan, Roser, Katharina, Göttgens, Irene, Stollman, Iridi, Penson, Adriaan, Breij, Dionne, Araujo-Soares, Vera, Essiaf, Samira, Blondeel, Anne, Sciberras, William, Korevaar, Joke, Rijken, Mieke, Kienesberger, Anita, den Hartogh, Jaap, Gsell, Hannah, Schneider, Carina, Bardi, Edit, te Dorsthorst, Jeroen, CCA - Cancer Treatment and Quality of Life, Amsterdam Reproduction & Development (AR&D), Paediatric Oncology, and Paediatrics
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Physical activity ,Motivational interviewing ,Medicine (miscellaneous) ,Person-centred care ,Feasibility ,and young adult cancer survivors ,Coaching ,Lifestyle ,Childhood ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,Diet ,Screen-to-screen ,All institutes and research themes of the Radboud University Medical Center ,adolescent ,eHealth ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] ,Childhood, adolescent, and young adult cancer survivors - Abstract
Background Physical inactivity and unhealthy dietary habits are known to be disadvantageous for the development of late adverse effects in survivors of childhood, adolescent, and young adult cancer. To make interventions, aimed at improving lifestyle, fit into the daily life of survivors, interventions should be designed and delivered in a person-centred way with a limited time burden. As part of the European PanCareFollowUp project, an eHealth intervention was developed to support sustainable changes to physical activity levels and/or diet of childhood, adolescent, and young adult cancer survivors. This feasibility study aims to gain insight into the feasibility and potential effect sizes of the PanCareFollowUp lifestyle intervention. Methods The PanCareFollowUp lifestyle intervention consists of person-centred 3–6 screen-to-screen sessions with a certified lifestyle coach. The intervention will be evaluated with a single-arm pre-post feasibility study conducted at two survivorship care clinics in the Netherlands. A total of 60 participants who are (i) diagnosed with cancer Discussion Data of this study will be gathered to assess the feasibility and potential effect sizes. This will allow for further intervention refinement as needed as well as to inform a future large-scale intervention study and a manual for implementation at other centres. Trial registration International Clinical Trial Registry Platform (ICTRP) number: NL8932 (ICTRP Search Portal (who.int)). Registered on September 29, 2020.
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- 2022
4. Late mortality among survivors of childhood acute lymphoblastic leukemia diagnosed during 1971–2008 in Denmark, Finland, and Sweden:A population-based cohort study
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Sørensen, Gitte V., Belmonte, Federica, Erdmann, Friederike, Mogensen, Hanna, Albieri, Vanna, Holmqvist, Anna S., Madanat-Harjuoja, Laura, Talbäck, Mats, Heyman, Mats M., Malila, Nea, Feychting, Maria, Schmiegelow, Kjeld, Winther, Jeanette F., Hasle, Henrik, Sørensen, Gitte V., Belmonte, Federica, Erdmann, Friederike, Mogensen, Hanna, Albieri, Vanna, Holmqvist, Anna S., Madanat-Harjuoja, Laura, Talbäck, Mats, Heyman, Mats M., Malila, Nea, Feychting, Maria, Schmiegelow, Kjeld, Winther, Jeanette F., and Hasle, Henrik
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Objective: Investigate all-cause and cause-specific late mortality after childhood acute lymphoblastic leukemia (ALL) in a population-based Nordic cohort. Methods: From the cancer registries of Denmark, Finland, and Sweden, we identified 3765 five-year survivors of ALL, diagnosed before age 20 during 1971–2008. For each survivor, up to five matched comparison subjects were randomly selected from the general population (n = 18,323). Causes of death were classified as relapse related, health related, and external. Late mortality was evaluated by cumulative incidences of death from 5-year survival date. Mortality hazard ratios (HR) were evaluated with Cox proportional models. Results: Among the survivors, 315 deaths occurred during a median follow-up of 16 years from 5-year survival date (range 0–42). The majority were attributable to relapse (n = 224), followed by second neoplasm (n = 45). Cumulative incidence of all-cause late mortality at 15 years from diagnosis decreased gradually over treatment decades, from 14.4% (95% confidence interval [CI]: 11.6–17.2) for survivors diagnosed during 1971–1981, to 2.5% (95% CI: 1.3–3.7) for those diagnosed during 2002–2008. This was mainly attributable to a reduction in relapse-related deaths decreasing from 13.4% (95% CI: 10.7–16.1) for survivors diagnosed during 1971–1981 to 1.9% (95% CI: 0.9–2.8) for those diagnosed during 2002–2008. Health-related late mortality was low and did not change substantially across treatment decades. Compared to comparison subjects, all-cause mortality HR was 40 (95% CI: 26–61) 5–9 years from diagnosis, and 4.4 (95% CI: 3.4–5.6) ≥10 years from diagnosis. Conclusions: Survivors of ALL have higher late mortality than population comparison subjects. Among the survivors, there was a temporal reduction in risk of death from relapse, without increments in health-related death.
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- 2022
5. Late mortality among survivors of childhood acute lymphoblastic leukemia diagnosed during 1971–2008 in Denmark, Finland, and Sweden: A population‐based cohort study
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Sørensen, Gitte V., primary, Belmonte, Federica, additional, Erdmann, Friederike, additional, Mogensen, Hanna, additional, Albieri, Vanna, additional, Holmqvist, Anna S., additional, Madanat‐Harjuoja, Laura, additional, Talbäck, Mats, additional, Heyman, Mats M., additional, Malila, Nea, additional, Feychting, Maria, additional, Schmiegelow, Kjeld, additional, Winther, Jeanette F., additional, and Hasle, Henrik, additional
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- 2021
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6. Late mortality among survivors of childhood acute lymphoblastic leukemia diagnosed during 1971–2008 in Denmark, Finland, and Sweden: A population‐based cohort study.
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Sørensen, Gitte V., Belmonte, Federica, Erdmann, Friederike, Mogensen, Hanna, Albieri, Vanna, Holmqvist, Anna S., Madanat‐Harjuoja, Laura, Talbäck, Mats, Heyman, Mats M., Malila, Nea, Feychting, Maria, Schmiegelow, Kjeld, Winther, Jeanette F., and Hasle, Henrik
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- 2022
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7. Temporal changes in the probability of live birth among female survivors of childhood cancer: A population‐based Adult Life After Childhood Cancer in Scandinavia (ALiCCS) study in five nordic countries.
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Licht, Sofie de Fine, Rugbjerg, Kathrine, Andersen, Elisabeth W., Nielsen, Thomas T., Norsker, Filippa Nyboe, Kenborg, Line, Holmqvist, Anna S., Madanat‐Harjuoja, Laura‐Maria, Tryggvadottir, Laufey, Stovall, Marilyn, Wesenberg, Finn, Hjorth, Lars, Hasle, Henrik, and Winther, Jeanette F.
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CHILDHOOD cancer ,CANCER patients ,CANCER survivors ,PROBABILITY theory ,MEDICAL registries - Abstract
BACKGROUND: During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births. METHODS: In total, 8886 women were identified in the 5 Nordic cancer registries in whom a childhood cancer had been diagnosed during 1954 through 2006. A population comparison cohort of 62,903 women was randomly selected from the central population registries matched by age and country. All women were followed for live births recorded in medical birth registries. The cumulative probability and the risk ratio (RR) with 95% confidence intervals (CIs) of a live birth were calculated by maternal age across treatment decades. RESULTS: The probability of a live birth increased with treatment decade, and, at age 30 years, the rate for survivors most recently diagnosed was close to the rate among the general population (1954‐1969: RR, 0.65 [95% CI, 0.54‐0.78]; 1970s: RR, 0.67 [95% CI, 0.60‐0.74]; 1980s: RR, 0.69 [95% CI, 0.64‐0.74]; 1990s: RR, 0.91 [95% CI, 0.87‐0.95]; 2000s: RR, 0.94 [95% CI, 0.91‐0.97]). CONCLUSIONS: Female childhood cancer survivors had a lower probability of a live birth than women in the general population, although, in survivors diagnosed after 1989, the probability was close to that of the general population. Because the pattern of live births differs by cancer type, continuous efforts must be made to preserve fertility, counsel survivors, and refer them rapidly to fertility treatment if necessary. LAY SUMMARY: The purpose of this study was to compare the probability of giving birth to a liveborn child in female survivors of childhood cancer with that of women in the general population.Survivors of childhood cancer had a lower probability of live births than women in the general population, although survivors diagnosed after 1989 had a probability close to that of the general population.Continuing focus on how to preserve the potential for fertility among female patients with childhood cancer during treatment is important to increase their chances of having a child. Female childhood cancer survivors have a lower probability of live birth than women in the general population. However, female survivors treated more recently in the 1990s and 2000s have a probability close to that of the female background population. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study
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Clausen, Camilla T., primary, Hasle, Henrik, additional, Holmqvist, Anna S., additional, Madanat-Harjuoja, Laura, additional, Tryggvadottir, Laufey, additional, Wesenberg, Finn, additional, Bautz, Andrea, additional, Winther, Jeanette F., additional, and Licht, Sofie de Fine, additional
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- 2018
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9. Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma—Identification of high‐risk populations to guide surveillance: A report from the Late Effects Study Group
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Holmqvist, Anna S., primary, Chen, Yanjun, additional, Berano Teh, Jennifer, additional, Sun, Canlan, additional, Birch, Jillian M., additional, van den Bos, Cor, additional, Diller, Lisa R., additional, Dilley, Kimberley, additional, Ginsberg, Jill, additional, Martin, Laura T., additional, Nagarajan, Rajaram, additional, Nathan, Paul C., additional, Neglia, Joseph P., additional, Terenziani, Monica, additional, Tishler, David, additional, Meadows, Anna T., additional, Robison, Leslie L., additional, Oberlin, Odile, additional, and Bhatia, Smita, additional
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- 2018
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10. Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study.
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Kenborg, Line, Linnet, Karen M., Fine Licht, Sofie, Bautz, Andrea, Holmqvist, Anna S., Tryggvadottir, Laufey, Madanat‐Harjuoja, Laura M., Stovall, Marilyn, Heilmann, Carsten, Albieri, Vanna, Hasle, Henrik, and Winther, Jeanette F.
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NERVOUS system tumors ,CHILDHOOD cancer ,HOSPITAL admission & discharge ,COHORT analysis ,DISEASES - Abstract
Large, comprehensive studies of the risk for neurologic disorders among long‐term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non‐CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5‐year survivors of non‐CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943–2008, and 151,118 matched population comparison subjects. In‐patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9–2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2–5.3) and leukemia (2.8; 95% CI 2.4–3.2). The AER decreased from 331 (278–383) excess neurologic disorders per 100,000 person‐years 5–9 years after diagnosis to 82 (46–118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis (n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non‐CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow‐up to identify those who require close management is needed. What's new? Although several studies have demonstrated increased risks for a wide range of late complications among survivors of non‐central nervous system (CNS) cancers in childhood, a comprehensive overview of neurologic disorders in this population is lacking. In a population‐based cohort study of 15,967 five‐year survivors, the authors report increased risks for several neurologic disorders, including epilepsy, paralytic syndromes, meningitis, hydrocephalus and nerve and degenerative disorders, with highest risks among survivors of neuroblastoma and leukemia. This is the first step toward identifying those survivors who will benefit from closer follow‐up to prevent severe neurologic disorders leading to hospitalization. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma-Identification of high-risk populations to guide surveillance: A report from the Late Effects Study Group.
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Holmqvist, Anna S., Chen, Yanjun, Berano Teh, Jennifer, Sun, Canlan, Birch, Jillian M., van den Bos, Cor, Diller, Lisa R., Dilley, Kimberley, Ginsberg, Jill, Martin, Laura T., Nagarajan, Rajaram, Nathan, Paul C., Neglia, Joseph P., Terenziani, Monica, Tishler, David, Meadows, Anna T., Robison, Leslie L., Oberlin, Odile, and Bhatia, Smita
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THYROID cancer , *TUMORS , *ALKYLATING agents , *HODGKIN'S disease , *CHILDREN , *CANCER risk factors , *HODGKIN'S disease treatment , *DRUG therapy , *PUBLIC health surveillance , *RADIOTHERAPY , *RISK assessment , *SECONDARY primary cancer , *DISEASE complications - Abstract
Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations.Methods: The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. The risk of SMN was estimated using proportional subdistribution hazards regression. The cohort included 1136 patients who were diagnosed with HL before age 17 years between 1955 and 1986. The median length of follow-up was 26.6 years.Results: In 162 patients, a total of 196 solid SMNs (sSMNs) were identified. Compared with the general population, the cohort was found to be at a 14-fold increased risk of developing an sSMN (95% confidence interval, 12.0-fold to 16.3-fold). The cumulative incidence of any sSMN was 26.4% at 40 years after a diagnosis of HL. Risk factors for breast cancer among females were an HL diagnosis between ages 10 years and 16 years and receipt of chest radiotherapy. Males treated with chest radiotherapy at age <10 years were found to be at highest risk of developing lung cancer. Survivors of HL who were treated with abdominal/pelvic radiotherapy and high-dose alkylating agents were found to be at highest risk of developing colorectal cancer and females exposed to neck radiotherapy at age <10 years were at highest risk of thyroid cancer. By age 50 years, the cumulative incidence of breast, lung, colorectal, and thyroid cancer was 45.3%, 4.2%, 9.5%, and 17.3%, respectively, among those at highest risk.Conclusions: Survivors of childhood HL remain at an increased risk of developing sSMNs. In the current study, subgroups of survivors of HL at highest risk of specific sSMNs were identified, and evidence for screening provided. [ABSTRACT FROM AUTHOR]- Published
- 2019
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12. Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.
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Clausen, Camilla T., Hasle, Henrik, Holmqvist, Anna S., Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Wesenberg, Finn, Bautz, Andrea, Winther, Jeanette F., and Licht, Sofie de Fine
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HYPERTHYROIDISM diagnosis ,HYPERTHYROIDISM ,CANCER patients ,CONFIDENCE intervals ,DISEASES ,HEAD tumors ,HODGKIN'S disease ,HOSPITAL care ,LYMPHOCYTIC leukemia ,NECK tumors ,NEUROBLASTOMA ,POPULATION geography ,THYROID gland tumors ,RELATIVE medical risk ,TUMORS in children ,ODDS ratio ,DISEASE complications ,TUMOR treatment ,DISEASE risk factors - Abstract
Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3-1.9) compared with population comparisons. The risk was greatest 1-5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity. [ABSTRACT FROM AUTHOR]
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- 2019
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13. Childhood cancer survivor cohorts in Europe
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Winther, Jeanette F., primary, Kenborg, Line, additional, Byrne, Julianne, additional, Hjorth, Lars, additional, Kaatsch, Peter, additional, Kremer, Leontien C. M., additional, Kuehni, Claudia E., additional, Auquier, Pascal, additional, Michel, Gérard, additional, de Vathaire, Florent, additional, Haupt, Riccardo, additional, Skinner, Roderick, additional, Madanat-Harjuoja, Laura M., additional, Tryggvadottir, Laufey, additional, Wesenberg, Finn, additional, Reulen, Raoul C., additional, Grabow, Desiree, additional, Ronckers, Cecile M., additional, van Dulmen-den Broeder, Eline, additional, van den Heuvel-Eibrink, Marry M., additional, Schindler, Matthias, additional, Berbis, Julie, additional, Holmqvist, Anna S., additional, Gudmundsdottir, Thorgerdur, additional, de Fine Licht, Sofie, additional, Bonnesen, Trine G., additional, Asdahl, Peter H., additional, Bautz, Andrea, additional, Kristoffersen, Anja K., additional, Himmerslev, Liselotte, additional, Hasle, Henrik, additional, Olsen, Jørgen H., additional, and Hawkins, Mike M., additional
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- 2015
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14. Childhood cancer survivor cohorts in Europe
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Grabow, Desiree, De Vathaire, Florent, Berbis, Julie, Kristoffersen, Anja K, Olsen, Jørgen H, Haupt, Riccardo, Tryggvadottir, Laufey, Holmqvist, Anna S, Bonnesen, Trine G, Kuehni, Claudia E, Kremer, Leontien C M, Himmerslev, Liselotte, Hawkins, Mike M, Wesenberg, Finn, Kenborg, Line, Madanat-Harjuoja, Laura M, Schindler, Matthias, Kaatsch, Peter, Byrne, Julianne, Hasle, Henrik, Hjorth, Lars, Van Den Heuvel-Eibrink, Marry M, Gudmundsdottir, Thorgerdur, Ronckers, Cecile M, Reulen, Raoul C, Skinner, Roderick, Auquier, Pascal, Van Dulmen-Den Broeder, Eline, Michel, Gérard, Bautz, Andrea, Winther, Jeanette F, Asdahl, Peter H, and De Fine Licht, Sofie
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal screening and care and to identify and provide adequate interventions. Childhood cancer survivor cohorts in Europe. Considerable advantages exist to study late effects in individuals treated for childhood cancer in a European context, including the complementary advantages of large population-based cancer registries and the unrivalled opportunities to study lifetime risks, together with rich and detailed hospital-based cohorts which fill many of the gaps left by the large-scale population-based studies, such as sparse treatment information. Several large national cohorts have been established within Europe to study late effects in individuals treated for childhood cancer including the Nordic Adult Life after Childhood Cancer in Scandinavia study (ALiCCS), the British Childhood Cancer Survivor Study (BCCSS), the Dutch Childhood Oncology Group (DCOG) LATER study, and the Swiss Childhood Cancer Survivor Study (SCCSS). Furthermore, there are other large cohorts, which may eventually become national in scope including the French Childhood Cancer Survivor Study (FCCSS), the French Childhood Cancer Survivor Study for Leukaemia (LEA), and the Italian Study on off-therapy Childhood Cancer Survivors (OTR). In recent years significant steps have been taken to extend these national studies into a larger pan-European context through the establishment of two large consortia - PanCareSurFup and PanCareLIFE. The purpose of this paper is to present an overview of the current large, national and pan-European studies of late effects after childhood cancer. This overview will highlight the strong cooperation across Europe, in particular the EU-funded collaborative research projects PanCareSurFup and PanCareLIFE. Overall goal. The overall goal of these large cohort studies is to provide every European childhood cancer survivor with better care and better long-term health so that they reach their full potential, and to the degree possible, enjoy the same quality of life and opportunities as their peers.
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