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3. Effects of topically applied heterologous serum on reepithelialization rate of superficial chronic corneal epithelial defects in dogs.

Author

Eaton, J Seth, Hollingsworth, Steven R, Holmberg, Bradford J, Brown, Michael H, Smith, Patricia J, and Maggs, David J

Subjects
Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Animals, Anti-Bacterial Agents, Atropine, Corneal Diseases, Dog Diseases, Dogs, Double-Blind Method, Drug Therapy, Combination, Female, Keratotomy, Radial, Male, Muscarinic Antagonists, Ophthalmic Solutions, Serum, Tobramycin, Treatment Outcome, Wound Healing, Veterinary Sciences
Abstract

OBJECTIVE To assess the effects of topical application of undiluted heterologous serum on time to corneal reepithelialization in dogs with superficial chronic corneal epithelial defects (SCCEDs). DESIGN Multicenter, randomized, double-masked, controlled clinical trial. ANIMALS 41 client-owned dogs. PROCEDURES After collection of baseline clinical and historical data, dogs were randomly assigned to receive topically applied undiluted heterologous serum (n = 22) or isotonic saline (0.9% NaCl) solution (19) along with tobramycin and atropine. Epithelial debridement (at all visits) and grid keratotomy (at visits 2, 3, and 4) of SCCEDs were performed. Ophthalmic examination including fluorescein application was performed once weekly for 4 weeks or until corneal reepithelialization. Clinicians and owners were masked to treatment group. RESULTS No differences in baseline data were detected between treatment groups. No difficulties with medication administration, noncompliance, or adverse reactions were noted. All SCCEDs in both groups healed by 4 weeks after treatment began. Median time to reepithelialization (2 weeks) was not significantly different between serum-treated and placebo-treated eyes. Irrespective of treatment group, median time to reepithelialization was not significantly different for Boxers versus non-Boxer breeds. Direct correlations were detected between time to reepithelialization and vascularization score at study entry, vascularization score at time of reepithelialization, and ulcer area at study entry in both groups. Time to reepithelialization was not correlated with age, sex, or duration of signs in either group. CONCLUSIONS AND CLINICAL RELEVANCE Topical application of undiluted heterologous serum was well tolerated by dogs with SCCEDs but, as an adjunct to standard treatment, did not reduce time to corneal reepithelialization.

Published
2017

4. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels

Author

Gomes, Filipe Espinheira, primary, Casanova, Maria Isabel, additional, Mouttham, Lara, additional, Bannasch, Danika L., additional, Park, Sangwan, additional, Kim, Soohyun, additional, Young, Laura J., additional, Daley, Nicole L., additional, Thomasy, Sara M., additional, Castelhano, Marta G., additional, Ledbetter, Eric C., additional, Holmberg, Bradford, additional, Boyd, Ryan, additional, Van Der Woerdt, Alexandra, additional, McDonald, Jessica, additional, and Hayward, Jessica J., additional

Published
2022
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5. Contributors

Author

Abbott, Jonathan A., primary, Adamantos, Sophie, additional, Adin, Christopher A., additional, Allen-Durrance, Ashley E., additional, Armentano, Robert A., additional, Aronson, Lillian R., additional, Balakrishnan, Anusha, additional, Beal, Matthew W., additional, Berent, Allyson, additional, Boag, Amanda K., additional, Boller, Elise Mittleman, additional, Boller, Manuel, additional, Boothe, Dawn Merton, additional, Borchers, Angela, additional, Boysen, Søren R., additional, Brainard, Benjamin M., additional, Brown, Andrew J., additional, Brown, Scott, additional, Burkitt, Jamie M., additional, Casal, Margret L., additional, Caulfield, Ann M., additional, Chan, Daniel L., additional, Chapman, Peter S., additional, Chastain, C.B., additional, Chew, Dennis J., additional, Clarke, Dana L., additional, Claus, Melissa A., additional, Cohn, Leah A., additional, Cooper, Edward, additional, Côté, Etienne, additional, Crane, M. Bronwyn, additional, Culp, William T.N., additional, Daly, Meredith L., additional, Davis, Emily, additional, Davis, Harold, additional, de Laforcade, Armelle, additional, DeFrancesco, Teresa, additional, Dixon-Jimenez, Amy, additional, Donahue, Suzanne, additional, Dowling, Patricia M., additional, Drobatz, Kenneth J., additional, Eatroff, Adam E., additional, Edwards, Melissa, additional, Eirmann, Laura, additional, Epstein, Steven, additional, Fletcher, Daniel J., additional, Francey, Thierry, additional, Fudge, Mack, additional, Garzotto, Caroline K., additional, Gaynor, Alison R., additional, Giger, Urs, additional, Giunti, Massimo, additional, Goggs, Robert A.N., additional, Goldstein, Richard E., additional, Green, Todd A., additional, Groman, Reid P., additional, Guillaumin, Julien, additional, Hackett, Tim B., additional, Hackner, Susan G., additional, Haldane, Sarah, additional, Hallowell, Terry C., additional, Harvey, Ralph C., additional, Haskins, Steve C., additional, Hayes, Galina, additional, Hess, Rebecka S., additional, Hoareau, Guillaume L., additional, Hogan, Daniel F., additional, Hollingsworth, Steven R., additional, Holmberg, Bradford J., additional, Holt, David, additional, Hopper, Kate, additional, Hughes, Dez, additional, Hume, Daniel Z., additional, Humm, Karen R., additional, Jandrey, Karl E., additional, Jasani, Shailen, additional, Johnson, Lynelle R., additional, Jutkowitz, L. Ari, additional, Kanakubo, Kayo, additional, Kerl, Marie E., additional, King, Lesley G., additional, Knipe, Marguerite F., additional, Koenig, Amie, additional, Labato, Mary Anna, additional, Langston, Catherine E., additional, Larsen, Jennifer A., additional, Larson, Victoria S., additional, LeCouteur, Richard A., additional, Lee, Justine A., additional, Lewis, Daniel Huw, additional, Li, Ronald, additional, Liu, Debra T., additional, MacDonald, Kristin A., additional, Machen, Maggie C., additional, Madden, Valerie, additional, Maglaras, Christina, additional, Mandell, Deborah C., additional, Mann, F.A. (Tony), additional, Martin, Linda G., additional, Massicotte, Christiane, additional, Mathews, Karol A., additional, Mazzaferro, Elisa M., additional, McIntyre, Robin L., additional, McMichael, Maureen, additional, Mehl, Margo, additional, Mellema, Matthew S., additional, Michel, Kathryn E., additional, Miller, Carrie J., additional, Miller, James B., additional, Moeser, Adam, additional, Otto, Cynthia M., additional, Oura, Trisha J., additional, Oyama, Mark A., additional, Palm, Carrie A., additional, Papich, Mark G., additional, Pariaut, Romain, additional, Perkowski, Sandra, additional, Pich, Michele, additional, Platt, Simon R., additional, Powell, Lisa Leigh, additional, Prošek, Robert, additional, Pypendop, Bruno H., additional, Quandt, Jane, additional, Rahilly, Louisa J., additional, Ralph, Alan G., additional, Rankin, Shelley C., additional, Rebar, Alan H., additional, Reineke, Erica L., additional, Reiss, Adam J., additional, Reynolds, Caryn, additional, Riordan, Laura L., additional, Robben, Joris H., additional, Robinson, Narda G., additional, Rondeau, Mark P., additional, Rosenstein, Patricia G., additional, Rousseau, Alexandre, additional, Rozanski, Elizabeth A., additional, Rudloff, Elke, additional, Santoro-Beer, Kari, additional, Sauvé, Valérie, additional, Savino, Emily, additional, Schaer, Michael, additional, Serrano, Sergio, additional, Sharp, Claire R., additional, Shaw, Scott P., additional, Sigrist, Nadja E., additional, Silverstein, Deborah C., additional, Sleeper, Meg, additional, Smarick, Sean, additional, Smart, Lisa, additional, Sorrell-Raschi, Laurie, additional, Steinberg, Sheldon A., additional, Stewart, Randolph H., additional, Sturges, Beverly K., additional, Sykes, Jane E., additional, Syring, Rebecca S., additional, Todd, Jeffrey M., additional, Trotman, Tara K., additional, Vernau, Karen M., additional, Villaverde, Cecilia, additional, Vite, Charles H., additional, Volk, Susan W., additional, Waddell, Lori S., additional, Wang, Andrea, additional, Ward, Cynthia R., additional, Ware, Wendy A., additional, Wey, Aaron C., additional, Willard, Michael D., additional, Winkler, Kevin P., additional, Wright, Annie Malouin, additional, Wright, Bonnie, additional, and Wright, Kathy N., additional

Published
2015
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8. Contributors

Author

Abbott, Jonathan A., primary, Adamantos, Sophie, additional, Aldrich, Janet, additional, Alwood, Amy J., additional, Aronson, Lillian R., additional, Bagley, Rodney S., additional, Barton, Linda, additional, Bateman, Shane W., additional, Beal, Matthew W., additional, Berent, Allyson C., additional, Bergman, Philip J., additional, Boag, Amanda K., additional, Mittleman Boller, Elise, additional, Boller, Manuel, additional, Bond, Betsy R., additional, Boothe, Dawn M., additional, Boysen, Søren R., additional, Brainard, Benjamin M., additional, Brown, Andrew J., additional, Brown, Scott, additional, Burkett, Dennis E., additional, Burkitt, Jamie M., additional, Chan, Daniel L., additional, Chapman, Peter S., additional, Chastain, C.B., additional, Chew, Dennis J., additional, Clare, Monica C., additional, Cohn, Leah A., additional, Cole, Steven G., additional, Costello, Merilee F., additional, Côté, Etienne, additional, Crane, M. Bronwyn, additional, (Tim) Crowe, Dennis T., additional, Culp, William T.N., additional, Daly, Meredith L., additional, Davis, Harold, additional, DeFrancesco, Teresa, additional, de Laforcade, Armelle M., additional, Donahue, Suzanne, additional, Dosher, Kristi L., additional, Dowling, Patricia M., additional, Drellich, Sharon, additional, Drobatz, Kenneth J., additional, Joel Edwards, N., additional, Eirmann, Laura, additional, Elliott, Denise A., additional, Fischer, Julie R., additional, Fletcher, Daniel J., additional, Francey, Thierry, additional, Fudge, Mack, additional, Garzotto, Caroline K., additional, Gaynor, Alison R., additional, Giger, Urs, additional, Giunti, Massimo, additional, Goggs, Robert, additional, Goldstein, Richard E., additional, Green, Todd, additional, Groman, Reid P., additional, Hackett, Timothy B., additional, Hackner, Susan G., additional, Hall, Kelly, additional, Harvey, Ralph C., additional, Hess, Rebecka S., additional, Hogan, Daniel F., additional, Hollingsworth, Steven R., additional, Holmberg, Bradford J., additional, Holt, David, additional, Hopper, Kate, additional, Hughes, Dez, additional, Hume, Daniel Z., additional, Humm, Karen R., additional, Jandrey, Karl E., additional, Jasani, Shailen, additional, Johnson, Kersten, additional, Johnson, Lynelle R., additional, Ari Jutkowitz, L., additional, Kerl, Marie E., additional, King, Lesley G., additional, Klide, Alan M., additional, Koenig, Amie, additional, Kovacic, Jan P., additional, Knipe, Marguerite F., additional, Kutzler, Michelle A., additional, Anna Labato, Mary, additional, Langston, Catherine E., additional, Larson, Victoria, additional, Laste, Nancy J., additional, LeCouteur, Richard A., additional, Lee, Justine A., additional, Lehman, Tracy L., additional, Malouin, Annie, additional, Mandell, Deborah C., additional, Mann, F.A., additional, Martin, Linda G., additional, Mazzaferro, Elisa M., additional, McMichael, Maureen, additional, Mehl, Margo, additional, Kate Meier, C., additional, Mellema, Matthew S., additional, Michel, Kathryn E., additional, Miller, Carrie J., additional, Miller, James B., additional, Monnet, Eric, additional, Murphy, Lisa A., additional, Christopher Orton, E., additional, Otto, Cynthia M., additional, Oyama, Mark A., additional, Pariaut, Romain, additional, Perkowski, Sandra Z., additional, Peterson, Michael E., additional, Platt, Simon R., additional, Leigh Powell, Lisa, additional, Prošek, Robert, additional, Pypendop, Bruno H., additional, Quandt, Jane, additional, Rahilly, Louisa, additional, Rankin, Shelley C., additional, Rebar, Alan H., additional, Lynn Reineke, Erica, additional, Reiss, Adam J., additional, Rieser, Teresa M., additional, Riordan, Laura L., additional, Robinson, Narda G., additional, Rochat, Mark C., additional, Rollings, Christopher, additional, Rondeau, Mark P., additional, Rozanski, Elizabeth A., additional, Rudloff, Elke, additional, Sauvé, Valérie, additional, Schaer, Michael, additional, Schildt, Julie C., additional, Scott, Nancy E., additional, Serrano, Sergio, additional, Shaw, Scott P., additional, Sigrist, Nadja E., additional, Silverstein, Deborah C., additional, Simmons, Jeffery P., additional, Sleeper, Meg, additional, Slensky, Kimberly, additional, Smarick, Sean, additional, Sorrell-Raschi, Laurie, additional, Sturges, Beverly K., additional, Sykes, Jane E., additional, Syring, Rebecca S., additional, Tocci, Lynel J., additional, Todd, Jeffrey, additional, Trotman, Tara K., additional, Vernau, Karen M., additional, Vite, Charles H., additional, Volk, Susan W., additional, Waddell, Lori S., additional, Ward, Cynthia R., additional, Ware, Wendy A., additional, Wey, Aaron C., additional, Willard, Michael D., additional, Winkler, Kevin P., additional, Wohl, James S., additional, Wright, Bonnie, additional, and Wright, Kathy N., additional

Published
2009
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20. Taenia coenurus in the orbit of a chinchilla.

Author

Holmberg, Bradford J., Hollingsworth, Steven R., Osofsky, Anna, and Tell, Lisa A.

Subjects
*CHINCHILLAS, *EXOPHTHALMOS, *EYE-sockets, *TAENIA, *EYE abnormalities
Abstract

A 4-year old, male intact, captive-bred chinchilla ( Chinchilla lanigera) was presented due to progressive exophthalmos of the right eye over a 5-month period. Ophthalmic examination revealed exophthalmos with dorsal displacement of the right globe. Retropulsion was decreased and a fluctuant, subcutaneous mass could be palpated posterior and dorsal to the central aspect of the zygomatic bone. Transdermal ultrasonography revealed a fluid-filled mass consistent with a cyst located within the ventral right orbit. Computed tomography demonstrated dorsal displacement of the globe, lateral displacement of the zygomatic arch, and numerous mineral-dense foci within the lumen of the cyst. The cyst was removed en bloc by ventral transpalpebral orbitotomy. Histopathology revealed a single capsulated cyst with multiple invaginated protoscolices, characterized by a prominent scolex with refractile hooklets, suckers, and abundant calcareous corpuscles consistent with a Taenia coenurus. Exophthalmos resolved with surgical therapy and there was no evidence of recurrence or postoperative complications over a period of 2 years. To the authors’ knowledge, this is the first reported case of an orbital cyst of parasitic origin in a chinchilla. [ABSTRACT FROM AUTHOR]

Published
2007
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21. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels.

Author

Espinheira Gomes, Filipe, Isabel Casanova, Maria, Mouttham, Lara, Bannasch, Danika L., Sangwan Park, Soohyun Kim, Young, Laura J., Daley, Nicole L., Thomasy, Sara M., Castelhano, Marta G., Ledbetter, Eric C., Holmberg, Bradford, Boyd, Ryan, Van Der Woerdt, Alexandra, McDonald, Jessica, and Hayward, Jessica J.

Subjects
*GENOME-wide association studies, *LOCUS (Genetics), *SINGLE nucleotide polymorphisms, *GLAUCOMA, *OPEN-angle glaucoma
Abstract

OBJECTIVE To identify genetic associations with primary glaucoma (PG) in American Cocker Spaniels using a genome-wide association study (GWAS). ANIMALS A nationwide ambidirectional case–control cohort study was performed in American Cocker Spaniels that had an ophthalmic examination performed by a veterinarian. Ninety-four dogs with PG (cases) and 111 dogs without glaucoma (controls) met phenotypic criteria and had a blood sample collected after receiving informed owner consent. PROCEDURES Genomic DNA was extracted from whole blood samples and genotyped (CanineHD BeadChip, Illumina Inc). A case–control GWAS using a linear mixed model was performed, and 3 significance thresholds were calculated (1) using a Bonferroni correction on all single nucleotide polymorphisms (SNPs) included in the GWAS, (2) using a Bonferroni correction on only the unlinked SNPs from a pruned data set, and (3) using 10,000 random phenotype permutations. RESULTS Following genotype data quality control, 89 cases and 93 controls were included in the GWAS. We identified an association on canine chromosome (CFA10); however, it did not reach statistical significance. Potential candidate genes within the surrounding linkage disequilibrium interval include coiled-coil domain containing 85A (CCDC85A) and extracellular growth factor containing fibulin extracellular matrix protein 1 (EFEMP1). CLINICAL RELEVANCE Primary glaucoma in the American Cocker Spaniel is a complex heterogeneous disease that may be influenced by a locus on CFA10. The candidate genes CCDC85A and EFEMP1 within the identified linkage disequilibrium interval have been shown to be involved in human open-angle glaucoma. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Contributors

Author

Abbott, Jonathan A., Adamantos, Sophie, Aldrich, Janet, Alwood, Amy J., Aronson, Lillian R., Bagley, Rodney S., Barton, Linda, Bateman, Shane W., Beal, Matthew W., Berent, Allyson C., Bergman, Philip J., Boag, Amanda K., Mittleman Boller, Elise, Boller, Manuel, Bond, Betsy R., Boothe, Dawn M., Boysen, Søren R., Brainard, Benjamin M., Brown, Andrew J., Brown, Scott, Burkett, Dennis E., Burkitt, Jamie M., Chan, Daniel L., Chapman, Peter S., Chastain, C.B., Chew, Dennis J., Clare, Monica C., Cohn, Leah A., Cole, Steven G., Costello, Merilee F., Côté, Etienne, Crane, M. Bronwyn, (Tim) Crowe, Dennis T., Culp, William T.N., Daly, Meredith L., Davis, Harold, DeFrancesco, Teresa, de Laforcade, Armelle M., Donahue, Suzanne, Dosher, Kristi L., Dowling, Patricia M., Drellich, Sharon, Drobatz, Kenneth J., Joel Edwards, N., Eirmann, Laura, Elliott, Denise A., Fischer, Julie R., Fletcher, Daniel J., Francey, Thierry, Fudge, Mack, Garzotto, Caroline K., Gaynor, Alison R., Giger, Urs, Giunti, Massimo, Goggs, Robert, Goldstein, Richard E., Green, Todd, Groman, Reid P., Hackett, Timothy B., Hackner, Susan G., Hall, Kelly, Harvey, Ralph C., Hess, Rebecka S., Hogan, Daniel F., Hollingsworth, Steven R., Holmberg, Bradford J., Holt, David, Hopper, Kate, Hughes, Dez, Hume, Daniel Z., Humm, Karen R., Jandrey, Karl E., Jasani, Shailen, Johnson, Kersten, Johnson, Lynelle R., Ari Jutkowitz, L., Kerl, Marie E., King, Lesley G., Klide, Alan M., Koenig, Amie, Kovacic, Jan P., Knipe, Marguerite F., Kutzler, Michelle A., Anna Labato, Mary, Langston, Catherine E., Larson, Victoria, Laste, Nancy J., LeCouteur, Richard A., Lee, Justine A., Lehman, Tracy L., Malouin, Annie, Mandell, Deborah C., Mann, F.A., Martin, Linda G., Mazzaferro, Elisa M., McMichael, Maureen, Mehl, Margo, Kate Meier, C., Mellema, Matthew S., Michel, Kathryn E., Miller, Carrie J., Miller, James B., Monnet, Eric, Murphy, Lisa A., Christopher Orton, E., Otto, Cynthia M., Oyama, Mark A., Pariaut, Romain, Perkowski, Sandra Z., Peterson, Michael E., Platt, Simon R., Leigh Powell, Lisa, Prošek, Robert, Pypendop, Bruno H., Quandt, Jane, Rahilly, Louisa, Rankin, Shelley C., Rebar, Alan H., Lynn Reineke, Erica, Reiss, Adam J., Rieser, Teresa M., Riordan, Laura L., Robinson, Narda G., Rochat, Mark C., Rollings, Christopher, Rondeau, Mark P., Rozanski, Elizabeth A., Rudloff, Elke, Sauvé, Valérie, Schaer, Michael, Schildt, Julie C., Scott, Nancy E., Serrano, Sergio, Shaw, Scott P., Sigrist, Nadja E., Silverstein, Deborah C., Simmons, Jeffery P., Sleeper, Meg, Slensky, Kimberly, Smarick, Sean, Sorrell-Raschi, Laurie, Sturges, Beverly K., Sykes, Jane E., Syring, Rebecca S., Tocci, Lynel J., Todd, Jeffrey, Trotman, Tara K., Vernau, Karen M., Vite, Charles H., Volk, Susan W., Waddell, Lori S., Ward, Cynthia R., Ware, Wendy A., Wey, Aaron C., Willard, Michael D., Winkler, Kevin P., Wohl, James S., Wright, Bonnie, and Wright, Kathy N.

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