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5 results on '"Holly J. Thompson"'

1. Tissue Expanders in Staged Calvarial Reconstruction: A Systematic Review

Author

Andrea Y. Lo, Roy P. Yu, Anjali C. Raghuram, Michael N. Cooper, Holly J. Thompson, Charles Y. Liu, and Alex K. Wong

Subjects
plastic surgery, cranioplasty, tissue expander, calvarium, Surgery, RD1-811
Abstract

Cranioplasties are common procedures in plastic surgery. The use of tissue expansion (TE) in staged cranioplasties is less common. We present two cases of cranioplasties with TE and systematically review literature describing the use of TE in staged cranioplasties and postoperative outcomes. A systematic review was performed by querying multiple databases. Eligible articles include published case series, retrospective reviews, and systematic reviews that described use of TE for staged bony cranioplasty. Data regarding study size, patient demographics, preoperative characteristics, staged procedure characteristics, and postoperative outcomes were collected. Of 755 identified publications, 26 met inclusion criteria. 85 patients underwent a staged cranioplasty with TE. Average defect size was 122 cm2, and 30.9% of patients received a previous reconstruction. Average expansion period was 14.2 weeks. The most common soft tissue closures were performed with skin expansion only (75.3%), free/pedicled flap (20.1%), and skin graft (4.7%). The mean postoperative follow-up time was 23.9 months. Overall infection and local complication rates were 3.53 and 9.41%, respectively. The most common complications were cerebrospinal fluid leak (7.1%), hematoma (7.1%), implant exposure (3.5%), and infection (3.5%). Factors associated with higher complication rates include the following: use of alloplastic calvarial implants and defects of congenital etiology (p = 0.023 and 0.035, respectively). This is the first comprehensive review to describe current practices and outcomes in staged cranioplasty with TE. Adequate soft tissue coverage contributes to successful cranioplasties and TE can play a safe and effective role in selected cases.

Published
2022
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2. Domains of professional practice: analysis of publications in the Journal of the Medical Library Association from 2010 to 2019

Author

Holly J. Thompson, Jill T. Boruff, Roy Brown, Alexander J. Carroll, John W. Cyrus, Melanie J. Norton, and Katherine G. Akers

Subjects
MLA domain hubs, content analysis, Bibliography. Library science. Information resources, Medicine
Abstract

The Medical Library Association (MLA) has defined 7 domain hubs aligning to different areas of information professional practice. To assess the extent to which content in the Journal of the Medical Library Association (JMLA) is reflective of these domains, we analyzed the magnitude of JMLA articles aligning to each domain hub over the last 10 years. Bibliographic records for 453 articles published in JMLA from 2010 to 2019 were downloaded from Web of Science and screened using Covidence software. Thirteen articles were excluded during the title and abstract review because they failed to meet the inclusion criteria, resulting in articles included in this review. The title and abstract of each article were screened by two reviewers, each of whom assigned the article up to two tags corresponding to MLA domain hubs (i.e., information services, information management, education, professionalism and leadership, innovation and research practice, clinical support, and health equity & global health). These results inform the MLA community about our strengths in health information professional practice as reflected by articles published in JMLA.

Published
2023
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4. A Self-Paced Online Library Orientation: Development, Implementation, and Assessment

Author

Hannah M. Schilperoort, Amy J. Chatfield, Jennifer E. Dinalo, Karin J. Saric, Holly J. Thompson, and Annie M. Thompson

Subjects
Libraries, Medical, Librarians, COVID-19, Humans, Health Informatics, Library and Information Sciences, Pandemics
Abstract

Health sciences librarians may find it difficult to meet demands for in-person or online synchronous library orientations for various reasons, including short-staffing of librarians, expansion of online programs, and temporary campus closures caused by emergencies, such as the COVID-19 pandemic. The authors discuss the development, implementation, and assessment of an asynchronous online orientation tutorial created for use across various health sciences degree, certificate, and training programs. The tutorial can either replace or supplement synchronous orientations, and the original tutorial can be copied and customized for specific programs.

Published
2022

5. Role of stem cell therapies in treating chronic wounds: A systematic review

Author

Alexander Wong, Holly J Thompson, Anjali C. Raghuram, Roy P. Yu, Melissa Bircan, Andrea Y. Lo, and Cynthia Sung

Subjects
0301 basic medicine, Chronic wound, Embryonic stem cells, Histology, Systematic Reviews, medicine.medical_treatment, Stem cell therapies, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, Genetics, Medicine, Molecular Biology, Genetics (clinical), Chronic wounds, Adult stem cells, business.industry, Regeneration (biology), Mesenchymal stem cell, Cell Biology, Stem-cell therapy, Embryonic stem cell, Erythroid precursor cells, 030104 developmental biology, 030220 oncology & carcinogenesis, Mesenchymal stem cells, Stem cell, medicine.symptom, business, Wound healing, Adult stem cell
Abstract

Background The impairment of cutaneous wound healing results in chronic, non-healing wounds that are caused by altered wound environment oxygenation, tissue injury, and permissive microbial growth. Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis. Consequently, stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity. Aim To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic, non-healing wounds. Methods PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus were queried with combinations of the search terms "mesenchymal stem cells," "adult stem cells," "embryonic stem cells," "erythroid precursor cells," "stem cell therapies," and "chronic wounds" in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts (reviews, case reports/series, retrospective/prospective studies, and clinical trials) were evaluated by the authors for their depiction of clinical stem cell therapy use. Data were extracted from the articles using a standardized collection tool. Results A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review. While stem cell therapies have been explored in in vitro and in vivo applications in the past, recent efforts are geared towards assessing their clinical role. A review of the literature revealed that adipose-derived stem cells, bone marrow-derived stem cells, bone marrow-derived mononuclear cells, epidermally-derived mesenchymal stem cells, fibroblast stem cells, keratinocyte stem cells, placental mesenchymal stem cells, and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies. Most recently, embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation. With the capacity for self-renewal and differentiation, stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing. Further, stem cell therapies can be utilized to augment cell engraftment, signaling and activity, and resultant patient outcomes. Conclusion Assessing observed clinical outcomes, potential for stem cell use, and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients' chronic wounds.

Published
2020

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