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Byline: Peter A Chyka, Joseph E Holley, Timothy D Mandrell, Prasanna Sugathan Abstract: Study objective: To evaluate an animal model of multiple-dose activated charcoal (MDAC) therapy and correlate the pharmacokinetic properties of four drugs with the efficacy of MDAC. Design: Prospective, randomized, controlled, crossover design. Setting: A university animal research facility. Participants: Seven female pigs (15 to 22 kg) with an indwelling central venous line and gastrostomy tube. Interventions: Acetaminophen (30 mg/kg), digoxin (30 [mu]g/kg), theophylline (8.9 mg/kg), and valproic acid (18 mg/kg) were simultaneously administered intravenously over 12 minutes. In the experimental arm, 25 g activated charcoal was administered at 0, 2, 4, 6, 12, 18, 24, and 30 hours through the gastric tube. In the control arm, an equal volume of water was given at the same times. Blood specimens were obtained over 36 hours to measure serum drug concentrations. Results: Each drug exhibited enhanced elimination (P Article History: Received 21 April 1994; Revised 19 September 1994; Accepted 1 October 1994 Article Note: (footnote) [star] From the Departments of Clinical Pharmacy*, Internal Medicinea , and Comparative MedicineAs., The University of Tennessee; and the Southern Poison Centera[yen]; Memphis, Tennessee., [star][star] Supported by a grant from Le Bonheur Children's Medical Center, Memphis, Tennessee., a Address for reprints: Peter A Chyka, PharmD, Southern Poison Center, 847 Monroe Avenue, Memphis, Tennessee 38163, 901-448-6802, aa Reprint no. 47/1/62401