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1. The Past, Present, and Future of the Brain Imaging Data Structure (BIDS)

Author

Poldrack, R, Markiewicz, C, Appelhoff, S, Ashar, Y, Auer, T, Baillet, S, Bansal, S, Beltrachini, L, Benar, C, Bertazzoli, G, Bhogawar, S, Blair, R, Bortoletto, M, Boudreau, M, Brooks, T, Calhoun, V, Castelli, F, Clement, P, Cohen, A, Cohen-Adad, J, D'Ambrosio, S, de Hollander, G, de la Iglesia-Vayá, M, de la Vega, A, Delorme, A, Devinsky, O, Draschkow, D, Duff, E, Dupre, E, Earl, E, Esteban, O, Feingold, F, Flandin, G, Galassi, A, Gallitto, G, Ganz, M, Gau, R, Gholam, J, Ghosh, S, Giacomel, A, Gillman, A, Gleeson, P, Gramfort, A, Guay, S, Guidali, G, Halchenko, Y, Handwerker, D, Hardcastle, N, Herholz, P, Hermes, D, Honey, C, Innis, R, Ioanas, H, Jahn, A, Karakuzu, A, Keator, D, Kiar, G, Kincses, B, Laird, A, Lau, J, Lazari, A, Legarreta, J, Li, A, Li, X, Love, B, Lu, H, Marcantoni, E, Maumet, C, Mazzamuto, G, Meisler, S, Mikkelsen, M, Mutsaerts, H, Nichols, T, Nikolaidis, A, Nilsonne, G, Niso, G, Norgaard, M, Okell, T, Oostenveld, R, Ort, E, Park, P, Pawlik, M, Pernet, C, Pestilli, F, Petr, J, Phillips, C, Poline, J, Pollonini, L, Raamana, P, Ritter, P, Rizzo, G, Robbins, K, Rockhill, A, Rogers, C, Rokem, A, Rorden, C, Routier, A, Saborit-Torres, J, Salo, T, Schirner, M, Smith, R, Spisak, T, Sprenger, J, Swann, N, Szinte, M, Takerkart, S, Thirion, B, Thomas, A, Torabian, S, Varoquaux, G, Voytek, B, Welzel, J, Wilson, M, Yarkoni, T, Gorgolewski, K, Poldrack, Russell A., Markiewicz, Christopher J., Appelhoff, Stefan, Ashar, Yoni K., Auer, Tibor, Baillet, Sylvain, Bansal, Shashank, Beltrachini, Leandro, Benar, Christian G., Bertazzoli, Giacomo, Bhogawar, Suyash, Blair, Ross W., Bortoletto, Marta, Boudreau, Mathieu, Brooks, Teon L., Calhoun, Vince D., Castelli, Filippo Maria, Clement, Patricia, Cohen, Alexander L., Cohen-Adad, Julien, D'Ambrosio, Sasha, de Hollander, Gilles, de la Iglesia-Vayá, María, de la Vega, Alejandro, Delorme, Arnaud, Devinsky, Orrin, Draschkow, Dejan, Duff, Eugene Paul, DuPre, Elizabeth, Earl, Eric, Esteban, Oscar, Feingold, Franklin W., Flandin, Guillaume, Galassi, Anthony, Gallitto, Giuseppe, Ganz, Melanie, Gau, Rémi, Gholam, James, Ghosh, Satrajit S., Giacomel, Alessio, Gillman, Ashley G., Gleeson, Padraig, Gramfort, Alexandre, Guay, Samuel, Guidali, Giacomo, Halchenko, Yaroslav O., Handwerker, Daniel A., Hardcastle, Nell, Herholz, Peer, Hermes, Dora, Honey, Christopher J., Innis, Robert B., Ioanas, Horea-Ioan, Jahn, Andrew, Karakuzu, Agah, Keator, David B., Kiar, Gregory, Kincses, Balint, Laird, Angela R., Lau, Jonathan C., Lazari, Alberto, Legarreta, Jon Haitz, Li, Adam, Li, Xiangrui, Love, Bradley C., Lu, Hanzhang, Marcantoni, Eleonora, Maumet, Camille, Mazzamuto, Giacomo, Meisler, Steven L., Mikkelsen, Mark, Mutsaerts, Henk, Nichols, Thomas E., Nikolaidis, Aki, Nilsonne, Gustav, Niso, Guiomar, Norgaard, Martin, Okell, Thomas W., Oostenveld, Robert, Ort, Eduard, Park, Patrick J., Pawlik, Mateusz, Pernet, Cyril R., Pestilli, Franco, Petr, Jan, Phillips, Christophe, Poline, Jean-Baptiste, Pollonini, Luca, Raamana, Pradeep Reddy, Ritter, Petra, Rizzo, Gaia, Robbins, Kay A., Rockhill, Alexander P., Rogers, Christine, Rokem, Ariel, Rorden, Chris, Routier, Alexandre, Saborit-Torres, Jose Manuel, Salo, Taylor, Schirner, Michael, Smith, Robert E., Spisak, Tamas, Sprenger, Julia, Swann, Nicole C., Szinte, Martin, Takerkart, Sylvain, Thirion, Bertrand, Thomas, Adam G., Torabian, Sajjad, Varoquaux, Gael, Voytek, Bradley, Welzel, Julius, Wilson, Martin, Yarkoni, Tal, Gorgolewski, Krzysztof J., Poldrack, R, Markiewicz, C, Appelhoff, S, Ashar, Y, Auer, T, Baillet, S, Bansal, S, Beltrachini, L, Benar, C, Bertazzoli, G, Bhogawar, S, Blair, R, Bortoletto, M, Boudreau, M, Brooks, T, Calhoun, V, Castelli, F, Clement, P, Cohen, A, Cohen-Adad, J, D'Ambrosio, S, de Hollander, G, de la Iglesia-Vayá, M, de la Vega, A, Delorme, A, Devinsky, O, Draschkow, D, Duff, E, Dupre, E, Earl, E, Esteban, O, Feingold, F, Flandin, G, Galassi, A, Gallitto, G, Ganz, M, Gau, R, Gholam, J, Ghosh, S, Giacomel, A, Gillman, A, Gleeson, P, Gramfort, A, Guay, S, Guidali, G, Halchenko, Y, Handwerker, D, Hardcastle, N, Herholz, P, Hermes, D, Honey, C, Innis, R, Ioanas, H, Jahn, A, Karakuzu, A, Keator, D, Kiar, G, Kincses, B, Laird, A, Lau, J, Lazari, A, Legarreta, J, Li, A, Li, X, Love, B, Lu, H, Marcantoni, E, Maumet, C, Mazzamuto, G, Meisler, S, Mikkelsen, M, Mutsaerts, H, Nichols, T, Nikolaidis, A, Nilsonne, G, Niso, G, Norgaard, M, Okell, T, Oostenveld, R, Ort, E, Park, P, Pawlik, M, Pernet, C, Pestilli, F, Petr, J, Phillips, C, Poline, J, Pollonini, L, Raamana, P, Ritter, P, Rizzo, G, Robbins, K, Rockhill, A, Rogers, C, Rokem, A, Rorden, C, Routier, A, Saborit-Torres, J, Salo, T, Schirner, M, Smith, R, Spisak, T, Sprenger, J, Swann, N, Szinte, M, Takerkart, S, Thirion, B, Thomas, A, Torabian, S, Varoquaux, G, Voytek, B, Welzel, J, Wilson, M, Yarkoni, T, Gorgolewski, K, Poldrack, Russell A., Markiewicz, Christopher J., Appelhoff, Stefan, Ashar, Yoni K., Auer, Tibor, Baillet, Sylvain, Bansal, Shashank, Beltrachini, Leandro, Benar, Christian G., Bertazzoli, Giacomo, Bhogawar, Suyash, Blair, Ross W., Bortoletto, Marta, Boudreau, Mathieu, Brooks, Teon L., Calhoun, Vince D., Castelli, Filippo Maria, Clement, Patricia, Cohen, Alexander L., Cohen-Adad, Julien, D'Ambrosio, Sasha, de Hollander, Gilles, de la Iglesia-Vayá, María, de la Vega, Alejandro, Delorme, Arnaud, Devinsky, Orrin, Draschkow, Dejan, Duff, Eugene Paul, DuPre, Elizabeth, Earl, Eric, Esteban, Oscar, Feingold, Franklin W., Flandin, Guillaume, Galassi, Anthony, Gallitto, Giuseppe, Ganz, Melanie, Gau, Rémi, Gholam, James, Ghosh, Satrajit S., Giacomel, Alessio, Gillman, Ashley G., Gleeson, Padraig, Gramfort, Alexandre, Guay, Samuel, Guidali, Giacomo, Halchenko, Yaroslav O., Handwerker, Daniel A., Hardcastle, Nell, Herholz, Peer, Hermes, Dora, Honey, Christopher J., Innis, Robert B., Ioanas, Horea-Ioan, Jahn, Andrew, Karakuzu, Agah, Keator, David B., Kiar, Gregory, Kincses, Balint, Laird, Angela R., Lau, Jonathan C., Lazari, Alberto, Legarreta, Jon Haitz, Li, Adam, Li, Xiangrui, Love, Bradley C., Lu, Hanzhang, Marcantoni, Eleonora, Maumet, Camille, Mazzamuto, Giacomo, Meisler, Steven L., Mikkelsen, Mark, Mutsaerts, Henk, Nichols, Thomas E., Nikolaidis, Aki, Nilsonne, Gustav, Niso, Guiomar, Norgaard, Martin, Okell, Thomas W., Oostenveld, Robert, Ort, Eduard, Park, Patrick J., Pawlik, Mateusz, Pernet, Cyril R., Pestilli, Franco, Petr, Jan, Phillips, Christophe, Poline, Jean-Baptiste, Pollonini, Luca, Raamana, Pradeep Reddy, Ritter, Petra, Rizzo, Gaia, Robbins, Kay A., Rockhill, Alexander P., Rogers, Christine, Rokem, Ariel, Rorden, Chris, Routier, Alexandre, Saborit-Torres, Jose Manuel, Salo, Taylor, Schirner, Michael, Smith, Robert E., Spisak, Tamas, Sprenger, Julia, Swann, Nicole C., Szinte, Martin, Takerkart, Sylvain, Thirion, Bertrand, Thomas, Adam G., Torabian, Sajjad, Varoquaux, Gael, Voytek, Bradley, Welzel, Julius, Wilson, Martin, Yarkoni, Tal, and Gorgolewski, Krzysztof J.

Abstract

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some of the challenges being addressed as it evolves. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS.

Published
2024

2. The Past, Present, and Future of the Brain Imaging Data Structure (BIDS)

Author

Poldrack, R. A., Markiewicz, C. J., Appelhoff, S., Ashar, Y. K., Auer, T., Baillet, S., Bansal, S., Beltrachini, L., Bertazzoli, G., Bhogawar, S., Blair, R. W., Bortoletto, M., Boudreau, M., Brooks, T. L., Bénar, C. G., Calhoun, V. D., Castelli, F. M., Clement, P., Cohen, A. L., Cohen-Adad, J., Dambrosio, S., Delorme, A., Devinsky, O., Draschkow, D., Duff, E. P., Dupre, E., Earl, E., Esteban, O., Feingold, F. W., Flandin, G., Galassi, A., Gallitto, G., Ganz, M., Gholam, J., Ghosh, S. S., Giacomel, A., Gillman, A. G., Gleeson, P., Gramfort, A., Guay, S., Guidali, G., Halchenko, Y. O., Handwerker, D. A., Hardcastle, N., Herholz, P., Hermes, D., Honey, C. J., Innis, R. B., Ioanas, H.-I., Jahn, A., Karakuzu, A., Keator, D. B., Kiar, G., Kincses, B., Laird, A. R., Lau, J. C., Lazari, A., Legarreta, J. H., Li, A., Li, X., Love, B. C., Lu, H., Maumet, C., Mazzamuto, G., Meisler, S. L., Mikkelsen, M., Mutsaerts, H., Nichols, T. E., Nikolaidis, A., Nilsonne, G., Niso, G., Norgaard, M., Okell, T. W., Oostenveld, R., Ort, E., Park, P. J., Pawlik, M., Pernet, C. R., Pestilli, F., (0000-0002-3201-6002) Petr, J., Phillips, C., Poline, J.-B., Pollonini, L., Raamana, P. R., Ritter, P., Rizzo, G., Robbins, K. A., Rockhill, A. P., Rogers, C., Rokem, A., Rorden, C., Routier, A., Saborit-Torres, J. M., Salo, T., Schirner, M., Smith, R. E., Spisak, T., Sprenger, J., Swann, N. C., Szinte, M., Takerkart, S., Thirion, B., Thomas, A. G., Torabian, S., Varoquaux, G., Vaya, M. D. L. I., Voytek, B., Welzel, J., Wilson, M., Hollander, G., Vega, A., Gorgolewski, K. J., Poldrack, R. A., Markiewicz, C. J., Appelhoff, S., Ashar, Y. K., Auer, T., Baillet, S., Bansal, S., Beltrachini, L., Bertazzoli, G., Bhogawar, S., Blair, R. W., Bortoletto, M., Boudreau, M., Brooks, T. L., Bénar, C. G., Calhoun, V. D., Castelli, F. M., Clement, P., Cohen, A. L., Cohen-Adad, J., Dambrosio, S., Delorme, A., Devinsky, O., Draschkow, D., Duff, E. P., Dupre, E., Earl, E., Esteban, O., Feingold, F. W., Flandin, G., Galassi, A., Gallitto, G., Ganz, M., Gholam, J., Ghosh, S. S., Giacomel, A., Gillman, A. G., Gleeson, P., Gramfort, A., Guay, S., Guidali, G., Halchenko, Y. O., Handwerker, D. A., Hardcastle, N., Herholz, P., Hermes, D., Honey, C. J., Innis, R. B., Ioanas, H.-I., Jahn, A., Karakuzu, A., Keator, D. B., Kiar, G., Kincses, B., Laird, A. R., Lau, J. C., Lazari, A., Legarreta, J. H., Li, A., Li, X., Love, B. C., Lu, H., Maumet, C., Mazzamuto, G., Meisler, S. L., Mikkelsen, M., Mutsaerts, H., Nichols, T. E., Nikolaidis, A., Nilsonne, G., Niso, G., Norgaard, M., Okell, T. W., Oostenveld, R., Ort, E., Park, P. J., Pawlik, M., Pernet, C. R., Pestilli, F., (0000-0002-3201-6002) Petr, J., Phillips, C., Poline, J.-B., Pollonini, L., Raamana, P. R., Ritter, P., Rizzo, G., Robbins, K. A., Rockhill, A. P., Rogers, C., Rokem, A., Rorden, C., Routier, A., Saborit-Torres, J. M., Salo, T., Schirner, M., Smith, R. E., Spisak, T., Sprenger, J., Swann, N. C., Szinte, M., Takerkart, S., Thirion, B., Thomas, A. G., Torabian, S., Varoquaux, G., Vaya, M. D. L. I., Voytek, B., Welzel, J., Wilson, M., Hollander, G., Vega, A., and Gorgolewski, K. J.

Abstract

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, and the mechanisms by which it has been extended. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS.

Published
2024

11. Sonic Hedgehog regulates thymic epithelial cell differentiation

Author

Saldana, J, Solanki, A, Lau, C, Sahni, H, Ross, S, Furmanski, A, Ono, M, Hollander, G, and Crompton, T

Subjects
animal structures, Short Communication, Immunology, education, Mice, Transgenic, Thymus Gland, Mice, Immunology and Allergy, Animals, Humans, Hedgehog Proteins, Mice, Knockout, Thymocytes, Sonic hedgehog, T cell, hemic and immune systems, Cell Differentiation, Epithelial Cells, mTEC, MHCII, embryonic structures, Thymic epithelium, cTEC, tissues, Morphogen, Signal Transduction
Abstract

Sonic Hedgehog (Shh) is expressed in the thymus, where it regulates T cell development. Here we investigated the influence of Shh on thymic epithelial cell (TEC) development. Components of the Hedgehog (Hh) signalling pathway were expressed by TEC, and use of a Gli Binding Site-green fluorescence protein (GFP) transgenic reporter mouse demonstrated active Hh-dependent transcription in TEC in the foetal and adult thymus. Analysis of Shh-deficient foetal thymus organ cultures (FTOC) showed that Shh is required for normal TEC differentiation. Shh-deficient foetal thymus contained fewer TEC than wild type (WT), the proportion of medullary TEC was reduced relative to cortical TEC, and cell surface expression of MHC Class II molecules was increased on both cortical and medullary TEC populations. In contrast, the Gli3-deficient thymus, which shows increased Hh-dependent transcription in thymic stroma, had increased numbers of TEC, but decreased cell surface expression of MHC Class II molecules on both cortical and medullary TEC. Neutralisation of endogenous Hh proteins in WT FTOC led to a reduction in TEC numbers, and in the proportion of mature Aire-expressing medullary TEC, but an increase in cell surface expression of MHC Class II molecules on medullary TEC. Likewise, conditional deletion of Shh from TEC in the adult thymus resulted in alterations in TEC differentiation and consequent changes in T cell development. TEC numbers, and the proportion of mature Aire-expressing medullary TEC were reduced, and cell surface expression of MHC Class II molecules on medullary TEC was increased. Differentiation of mature CD4 and CD8 single positive thymocytes was increased, demonstrating the regulatory role of Shh production by TEC on T cell development. Treatment of human thymus explants with recombinant Shh or neutralising anti-Shh antibody indicated that the Hedgehog pathway is also involved in regulation of differentiation from DP to mature SP T cells in the human thymus., Highlights • TEC express components of the Hedgehog signalling pathway and transduce it's signals. • Sonic hedgehog (Shh) is required for normal TEC development. • Sonic hedgehog particularly influences differentiation to the medullary TEC lineage. • Shh regulates cell surface MHCII expression on both cortical and medullary TEC.

Published
2016

15. Comparison of T2* and QSM contrasts in Parkinson’s disease to visualize the STN with MRI

Author

Alkemade, A., de Hollander, G., Keuken, M.C., Schäfer, A., Ott, D.V.M., Schwarz, J., Weise, D., Kotz, S.A., Forstmann, B.U., Ontwikkelingspsychologie (Psychologie, FMG), FMG, Psychology Other Research (FMG), and Brein en Cognitie (Psychologie, FMG)

Abstract

The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson’s disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD. Using 7T MRI, the present study set out to investigate which MRI contrasts yielded the best results for STN visualization in 12 PD patients and age-matched healthy controls (HC). We found that STNs were more difficult to delineate in PD as reflected by a lower inter-rater agreement when compared to HCs. No STN size differences were observed between the groups. Analyses of quantitative susceptibility mapping (QSM) images showed a higher inter-rater agreement reflected by increased Dice-coefficients. The location of the center of mass of the STN was not affected by contrast. Overall, contrast-to-noise ratios (CNR) were higher in QSM than in T2*-weighted images. This can at least partially, explain the higher inter-rater agreement in QSM. The current results indicate that the calculation of QSM contrasts contributes to an improved visualization of the entire STN. We conclude that QSM contrast is the preferred choice for the visualization of the STN in persons with PD as well as in aging HC.

Published
2017

16. Comparing functional MRI protocols for small, iron-rich basal ganglia nuclei such as the subthalamic nucleus at 7 T and 3 T

Author

de Hollander, G., Keuken, M.C., van der Zwaag, W., Forstmann, B.U., Trampel, R., Spinoza Centre for Neuroimaging, Netherlands Institute for Neuroscience (NIN), FMG, Psychology Other Research (FMG), and Brein en Cognitie (Psychologie, FMG)

Subjects
Adult, Male, Brain Mapping, Iron, behavioral disciplines and activities, Magnetic Resonance Imaging, Basal Ganglia, Oxygen, Inhibition, Psychological, Young Adult, nervous system, Acoustic Stimulation, Subthalamic Nucleus, Image Processing, Computer-Assisted, Reaction Time, Journal Article, Humans, Female, psychological phenomena and processes, Research Articles
Abstract

The basal ganglia (BG) form a network of subcortical nuclei. Functional magnetic resonance imaging (fMRI) in the BG could provide insight in its functioning and the underlying mechanisms of Deep Brain Stimulation (DBS). However, fMRI of the BG with high specificity is challenging, because the nuclei are small and variable in their anatomical location. High resolution fMRI at field strengths of 7 Tesla (T) could help resolve these challenges to some extent. A set of MR protocols was developed for functional imaging of the BG nuclei at 3 T and 7 T. The protocols were validated using a stop‐signal reaction task (Logan et al. [1984]: J Exp Psychol: Human Percept Perform 10:276–291). Compared with sub‐millimeter 7 T fMRI protocols aimed at cortex, a reduction of echo time and spatial resolution was strictly necessary to obtain robust Blood Oxygen Level Dependent (BOLD) sensitivity in the BG. An fMRI protocol at 3 T with identical resolution to the 7 T showed no robust BOLD sensitivity in any of the BG nuclei. The results suggest that the subthalamic nucleus, as well as the substantia nigra, red nucleus, and the internal and external parts of the globus pallidus show increased activation in failed stop trials compared with successful stop and go trials. Hum Brain Mapp 38:3226–3248, 2017. © 2017 Wiley Periodicals, Inc.

Published
2017

19. Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development

Author

Žuklys, S, Handel, A, Zhanybekova, S, Govani, F, Keller, M, Maio, S, Mayer, C, Teh, H, Hafen, K, Gallone, G, Barthlott, T, Ponting, C, and Hollander, G

Subjects
integumentary system
Abstract

Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1, however its target genes have never been physically identified. Using novel static and inducible genetic model systems and chromatin studies, we provide now a genome wide map of direct Foxn1 target genes for postnatal thymic epithelia and define the Foxn1 binding motif. We detail the function of Foxn1 in these cells and demonstrate that in addition to the transcriptional control of genes involved in the attraction and lineage commitment of T cell precursors, Foxn1 regulates the expression of genes involved in antigen processing and thymocyte selection. Thus, critical events in thymic lympho-stromal cross-talk and T cell selection are indispensably choreographed by Foxn1.

Published
2016

21. Balans van de leefomgeving 2014 : de toekomst is nú

Author

Gerwen, O.J., Hoogervorst, N.J.P., Brandes, L., de Hollander, G., Eskinasi, M., Dam, F., Ros, J., van Grinsven, H., Nijland, H., Ligtvoet, W., van Gaalen, F., and Dirkx, G.H.P.

Subjects
ecosysteemdiensten, waterbeheer, flood control, policy evaluation, hoogwaterbeheersing, food supply, energiebeleid, landbouw, milieubeleid, environmental policy, water management, WOT Natuur & Milieu, voedselvoorziening, beleidsevaluatie, ecosystem services, energy policy, agriculture
Abstract

De Balans van de Leefomgeving geeft parlement, kabinet en samenleving een feitelijk onderbouwd inzicht in de huidige kwaliteit van de fysieke leefomgeving. De Balans is de tweejaarlijkse peilstok van het PBL die aangeeft in hoeverre de door de politiek zelf ten doel gestelde leefomgevingskwaliteit tijdig wordt bereikt. De Balans van de Leefomgeving 2014 heeft als motto meegekregen: de toekomst is nú.

Published
2014

22. A gradual increase of iron toward the medial‐inferior tip of the subthalamic nucleus

Author

de Hollander, G., Keuken, M.C., Bazin, P.-L., Weiss, M., Neumann, J., Reimann, K., Wähnert, M., Turner, R., Forstmann, B.U., Schäfer, A., and Ontwikkelingspsychologie (Psychologie, FMG)

Subjects
nervous system, nervous system diseases
Abstract

The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.

Published
2014

23. Technical Report on chemicals, particulate matter and human health, air quality and noise

Author

Smeets W, Pull A van, Eerens H, Sluyter R, Hollander G de, and MNV

Subjects
particulate matter, luchtkwaliteit, assessment, noise pollution, chemicals, costs, health, air quality, scenario, geluidshinder, chemicalien, risico's, scenario's, fijnstof, kosten, gezondheid, toetsing, risks
Abstract

Ondanks verbeteringen van het milieu in Europa op een aantal terreinen, is een aangescherpt milieubeleid in de Europese Unie noodzakelijk om de gezondheidsschade en het natuurverlies te beperken. Een kosten-batenanalyse wijst uit dat zo'n beleid robuust is en dat de macro-economische gevolgen beheersbaar zijn. Belangrijke prioriteiten voor het EU-milieubeleid zijn klimaatverandering, stikstof-eutrofiering, fijn stof, ozon en biodiversiteit. Dit zijn de belangrijkste bevindingen van een internationaal studieconsortium onder leiding van het RIVM. De studie is verricht in samenwerking met EFTEC (UK), NTUA (Griekenland), IIASA (Oostenrijk). Daarnaast hebben TNO en TME bijdragen geleverd. Ook is in het kader van de studie intensief samengewerkt met het Europese Milieuagentschap in Kopenhagen. De studie is verricht op verzoek van de Europese Commissie als bijdrage voor het zesde Milieu-Actieprogramma, dat door de Europese Commissie is gepresenteerd. In de studie stonden vijf vragen centraal: Is het huidige beleid adequaat genoeg? Kan technologie de geconstateerde beleidstekorten oplossen? Zijn ambitieusere milieudoelstellingen te realiseren? Zo ja, zijn deze doelen ook in economische zin verstandig? Welke beleidsreacties en -instrumenten zijn aan te bevelen? Deze vijf vragen zijn geanalyseerd voor twaalf Europese milieuproblemen, zoals klimaatverandering, biodiversiteit en chemische risico's. De analyse bestaat uit een analyse van de kosten van vermeden schade, milieu-uitgaven, risicoschattingen, publieke opinie, sociale gevolgen en duurzaamheid. De studie bevat ook informatie over milieudoelstellingen, scenario's en beleidsopties en - maatregelen, inclusief de kosten en baten hiervan. Dit rapport is het technische achtergrondrapport dat behoort bij het hoofdrapport. Er zijn twaalf technische achtergrondrapporten opgesteld, waarvan negen een specifiek milieuprobleem behandelen (analyse van het probleem, scenarios, kosten-batenanalyse en beleidsopties). Daarnaast zijn er drie algemene achtergrondrapporten opgesteld over de macro-economische gevolgen, de uitbreiding van de EU en de gehanteerde batenmethodiek.

Published
2012

25. Snellere en betere besluiten, erkennen van onzekerheden en risicomanagement

Author

Draaijers, G., Annema, J.A., Broekmeyer, M.E.A., de Hollander, G., van de Ven, H., and Blom, G.

Subjects
environmental impact reporting, regional planning, risk assessment, regionale planning, milieueffectrapportage, risicoschatting
Abstract

Onzekerheden in effectbepalingen zijn onvermijdbaar en meestal ook aanzienlijk. Het erkennen van deze onzekerheden en het beheersen van de bijbehorende risico's zal leiden tot snellere en betere besluiten. De gevolgen van praktische toepassing van risicomanagement voor de m.e.r.-praktijk.

Published
2010

26. VVI PACEMAKER, ATRIAL FIBRILLATION AND ANTICOAGULATION TRENDS

Author

Kabalkin, Chaim and Hollander, G

Subjects
Thromboembolism -- Risk factors, Anticoagulants (Medicine) -- Health aspects, Atrial fibrillation -- Health aspects -- Risk factors, Health, Risk factors, Health aspects
Abstract

Purpose: VVI pacing, being a regular rhythm and dominant feature of the EKG, may distract the physician from examining the underlying atrial rhythm. As a result underlying atrial fibrillation may [...]

Published
1999

27. CAN ECHOCARDIOGRAPHY DISTINGUISH BETWEEN ISCHEMIC AND NON-ISCHEMIC CARDIOMYOPATHY

Author

Birns, Jonathan, Moskovits, N, Torres, R, Greengart, A, Shani, J, Frankel, R, Greenberg, Y, Kerstein, J, Friedman, M, and Hollander, G

Subjects
Heart diseases -- Diagnosis, Echocardiography, Cardiomyopathy -- Diagnosis, Health, Diagnosis
Abstract

Purpose: In patients who present with severe left ventricular (LV) dysfunction, it is important to distinguish between those with and without coronary artery disease as this will influence the treatment [...]

Published
1999

29. De LeefOmgevingsVerkenner: Kaartbeelden van 2030. Een verkenning van de inzet bij beleidsondersteuning

Author

Nijs T de, Niet R de, Hollander G de, Rijks Planologische Dienst, and MNV

Subjects
demography, economy, beleid, assessment, grondgebruik, land use, planologie, planning, economie, toetsing, demografie, policy
Abstract

The applicability of the Environment Explorer was evaluated in a study by the National Institute of Public Health and the Environment (RIVM) in collaboration with the National Spatial Planning Agency (RPD). The Environment Explorer was developed for rapid, integrated assessments of the effects of different spatial policy options based on economic, social and ecological values. It works by sketching the spatial developments, land-use transformations and effects for the Netherlands on a set of indicators up to 2030 under given demographic and economic prognoses. In this study, the Environment Explorer was applied to three spatial policy options so as to examine its strengths and weaknesses. The instrument was found to allow rapid spatial exploration of developments in the "physical environment" of the Netherlands. The current experience with Environment Explorer and the discussions during the project have resulted in a number of recommendations for further validation and development of the instrument

Published
2007

32. The effects of climate change in the Netherlands: 2012

Author

van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., Wardekker, J.A., van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., and Wardekker, J.A.

Abstract

Although climate change is expected to continue, its negative impacts for the Netherlands appear manageable. Here, most climatic changes will take place more gradual than in many other regions, thus enabling citizens, companies and authorities to adapt. Furthermore, current policies focus attention on important aspects of climate change, such as the risk of flooding, drought and precipitation extremes.

Published
2013

33. The effects of climate change in the Netherlands: 2012

Author

Environmental Sciences, van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., Wardekker, J.A., Environmental Sciences, van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., and Wardekker, J.A.

Published
2013

34. Effecten van klimaatverandering in Nederland: 2012

Author

van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., Wardekker, J.A., van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., and Wardekker, J.A.

Published
2012

35. Effecten van klimaatverandering in Nederland: 2012

Author

Minnen, J. van, Ligtvoet, W., Bree, L. van, Hollander, G. de, Visser, H., Schrier, G. van der, Bessembinder, J., Oldenborgh, G.J. van, Prozny, T., Sluijter, R., Klein Tank, A.M.G., Sluijs, J.P. van der, Wardekker, J.A., Minnen, J. van, Ligtvoet, W., Bree, L. van, Hollander, G. de, Visser, H., Schrier, G. van der, Bessembinder, J., Oldenborgh, G.J. van, Prozny, T., Sluijter, R., Klein Tank, A.M.G., Sluijs, J.P. van der, and Wardekker, J.A.

Published
2012

36. Effecten van klimaatverandering in Nederland: 2012

Author

Environmental Sciences, Section Environmental Sciences, Sub Science, Technology & Society begr., van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., Wardekker, J.A., Environmental Sciences, Section Environmental Sciences, Sub Science, Technology & Society begr., van Minnen, J., Ligtvoet, W., van Bree, L., de Hollander, G., Visser, H., van der Schrier, G., Bessembinder, J., van Oldenborgh, G.J., Prozny, T., Sluijter, R., Klein Tank, A.M.G., van der Sluijs, J.P., and Wardekker, J.A.

Published
2012

37. De gezonde wereld: Gezondheidseffecten van klimaatverandering

Author

Huynen, M.M.T.E., Huynen, M.M.T.E., de Hollander, G, Martens, P., Mackenbach, J., Huynen, M.M.T.E., Huynen, M.M.T.E., de Hollander, G, Martens, P., and Mackenbach, J.

Abstract

Volgens de intergovernmental panel on climate change (ipcc) leidt klimaatverandering tot substantiële gezondheidsrisico’s.1 in 2009 nam de who een resolutie aan op het gebied van klimaatverandering en gezondheid die lidstaten oproept om verder onderzoek te verrichten naar het verband tussen klimaatverandering en gezondheidseffecten en beschermende maatregelen te nemen wanneer nodig.2 de europese commissie stelt dat klimaatverandering overduidelijk directe en indirecte schadelijke effecten op de volksgezondheid heeft en onderkent de noodzaak van (onderzoek naar) passende adaptatiemaatregelen.3 ook in nederland worden er uiteenlopende nadelige effecten op de nederlandse volksgezondheid verwacht en is een adequaat adaptatiebeleid noodzakelijk.4,5.

Published
2009

38. Takotsubo cardiomyopathy

Author

Chadha, S., primary, Lodha, A., additional, Shetty, V., additional, Sadiq, A., additional, Hollander, G., additional, and Shani, J., additional

Published
2013
Full Text
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41. Recommandations pratiques pour le traitement d'arythmies aiguës. Rapport du Groupe Interdisciplinaire Belge de Cardiologie Aiguë.

Author

Gevaert, Sofie, Vandekerckhove, Y, De Raedt, H, Renard, Marc, Hollander, G, Bossaert, Leo L., Vorlat, A, Calle, P, Martens, Paul, Evrard, P, Salembier, J, Verbeet, Thierry William, Vanoverschelde, Jean-Louis, Claeys, M., de Meestert, A, Belgium Interdisciplinary Working Group on Acute Cardiology, Gevaert, Sofie, Vandekerckhove, Y, De Raedt, H, Renard, Marc, Hollander, G, Bossaert, Leo L., Vorlat, A, Calle, P, Martens, Paul, Evrard, P, Salembier, J, Verbeet, Thierry William, Vanoverschelde, Jean-Louis, Claeys, M., de Meestert, A, and Belgium Interdisciplinary Working Group on Acute Cardiology

Abstract

Acute arrhythmia is a condition covering a wide variety of rhythm disturbances. The aim of the article is to give practical recommendations for the approach and the treatment of the patient presenting with an acute arrhythmia. We discuss bradycardia and tachycardia. Tachycardias are divided into the small QRS complex tachycardias and the wide QRS complex tachycardias. Another important distinction with immediate therapeutic consequences is that between the hemodynamic stable and unstable patient. Flowcharts with diagnostic means and therapeutic schemes are added and a table with practical considerations for electrical cardioversion., English Abstract, Guideline, Journal Article, Practice Guideline, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2004

44. De LeefOmgevingsVerkenner: Kaartbeelden van 2030. Een verkenning van de inzet bij beleidsondersteuning

Author

MNV, de Nijs T, de Niet R, de Hollander G, MNV, de Nijs T, de Niet R, and de Hollander G

Abstract

RIVM rapport:In samenwerking met de Rijksplanologische Dienst is de bruikbaarheid van de LeefOmgevingsVerkenner geevalueerd. De LeefOmgevingsVerkenner wordt bij het RIVM ontwikkeld om een snelle, interactieve, integrale afweging van verschillende beleidsopties te kunnen maken. De LeefOmgevingsVerkenner simuleert de ontwikkeling van het landgebruik in Nederland tot 2030 en het effect hiervan op een set van indicatoren, gegeven demografische en economische ontwikkelingen en de plannen voor de ontwikkeling van Ecologische Hoofdstructuur. In deze studie stond de vraag centraal of het instrument interactief gebruikt zou kunnen worden ter ondersteuning van beleid met betrekking tot de ruimtelijke ontwikkeling van Nederland. Aan de hand van een toepassing zijn de effecten van 3 ruimtelijke beleidsvarianten geanalyseerd. De ervaringen in deze toepassing laten zien dat het instrument de mogelijkheden biedt om snel een consistent beeld van de ontwikkeling van Nederland te schetsen aan de hand van landgebruikkaarten, indicatoren en geaggregeerde indices. De analyses kunnen snel, binnen enkele dagen, worden uitgevoerd. Op basis van de ervaringen uit deze studie is een lijst met aanbevelingen voor de verdere ontwikkeling en validatie van de LeefOmgevingsVerkenner opgesteld., The applicability of the Environment Explorer was evaluated in a study by the National Institute of Public Health and the Environment (RIVM) in collaboration with the National Spatial Planning Agency (RPD). The Environment Explorer was developed for rapid, integrated assessments of the effects of different spatial policy options based on economic, social and ecological values. It works by sketching the spatial developments, land-use transformations and effects for the Netherlands on a set of indicators up to 2030 under given demographic and economic prognoses. In this study, the Environment Explorer was applied to three spatial policy options so as to examine its strengths and weaknesses. The instrument was found to allow rapid spatial exploration of developments in the "physical environment" of the Netherlands. The current experience with Environment Explorer and the discussions during the project have resulted in a number of recommendations for further validation and development of the instrument

Published
2001

45. De LeefOmgevingsVerkenner: Kaartbeelden van 2030. Een verkenning van de inzet bij beleidsondersteuning

Author

Rijks Planologische Dienst, MNV, Nijs T de, Niet R de, Hollander G de, Rijks Planologische Dienst, MNV, Nijs T de, Niet R de, and Hollander G de

Abstract

RIVM rapport:The applicability of the Environment Explorer was evaluated in a study by the National Institute of Public Health and the Environment (RIVM) in collaboration with the National Spatial Planning Agency (RPD). The Environment Explorer was developed for rapid, integrated assessments of the effects of different spatial policy options based on economic, social and ecological values. It works by sketching the spatial developments, land-use transformations and effects for the Netherlands on a set of indicators up to 2030 under given demographic and economic prognoses. In this study, the Environment Explorer was applied to three spatial policy options so as to examine its strengths and weaknesses. The instrument was found to allow rapid spatial exploration of developments in the "physical environment" of the Netherlands. The current experience with Environment Explorer and the discussions during the project have resulted in a number of recommendations for further validation and development of the instrument, In samenwerking met de Rijksplanologische Dienst is de bruikbaarheid van de LeefOmgevingsVerkenner geevalueerd. De LeefOmgevingsVerkenner wordt bij het RIVM ontwikkeld om een snelle, interactieve, integrale afweging van verschillende beleidsopties te kunnen maken. De LeefOmgevingsVerkenner simuleert de ontwikkeling van het landgebruik in Nederland tot 2030 en het effect hiervan op een set van indicatoren, gegeven demografische en economische ontwikkelingen en de plannen voor de ontwikkeling van Ecologische Hoofdstructuur. In deze studie stond de vraag centraal of het instrument interactief gebruikt zou kunnen worden ter ondersteuning van beleid met betrekking tot de ruimtelijke ontwikkeling van Nederland. Aan de hand van een toepassing zijn de effecten van 3 ruimtelijke beleidsvarianten geanalyseerd. De ervaringen in deze toepassing laten zien dat het instrument de mogelijkheden biedt om snel een consistent beeld van de ontwikkeling van Nederland te schetsen aan de hand van landgebruikkaarten, indicatoren en geaggregeerde indices. De analyses kunnen snel, binnen enkele dagen, worden uitgevoerd. Op basis van de ervaringen uit deze studie is een lijst met aanbevelingen voor de verdere ontwikkeling en validatie van de LeefOmgevingsVerkenner opgesteld.

Published
2001

46. Technical Report on chemicals, particulate matter and human health, air quality and noise

Author

MNV, Smeets W, Pull A van, Eerens H, Sluyter R, Hollander G de, MNV, Smeets W, Pull A van, Eerens H, Sluyter R, and Hollander G de

Abstract

RIVM rapport:Ondanks verbeteringen van het milieu in Europa op een aantal terreinen, is een aangescherpt milieubeleid in de Europese Unie noodzakelijk om de gezondheidsschade en het natuurverlies te beperken. Een kosten-batenanalyse wijst uit dat zo'n beleid robuust is en dat de macro-economische gevolgen beheersbaar zijn. Belangrijke prioriteiten voor het EU-milieubeleid zijn klimaatverandering, stikstof-eutrofiering, fijn stof, ozon en biodiversiteit. Dit zijn de belangrijkste bevindingen van een internationaal studieconsortium onder leiding van het RIVM. De studie is verricht in samenwerking met EFTEC (UK), NTUA (Griekenland), IIASA (Oostenrijk). Daarnaast hebben TNO en TME bijdragen geleverd. Ook is in het kader van de studie intensief samengewerkt met het Europese Milieuagentschap in Kopenhagen. De studie is verricht op verzoek van de Europese Commissie als bijdrage voor het zesde Milieu-Actieprogramma, dat door de Europese Commissie is gepresenteerd. In de studie stonden vijf vragen centraal: Is het huidige beleid adequaat genoeg? Kan technologie de geconstateerde beleidstekorten oplossen? Zijn ambitieusere milieudoelstellingen te realiseren? Zo ja, zijn deze doelen ook in economische zin verstandig? Welke beleidsreacties en -instrumenten zijn aan te bevelen? Deze vijf vragen zijn geanalyseerd voor twaalf Europese milieuproblemen, zoals klimaatverandering, biodiversiteit en chemische risico's. De analyse bestaat uit een analyse van de kosten van vermeden schade, milieu-uitgaven, risicoschattingen, publieke opinie, sociale gevolgen en duurzaamheid. De studie bevat ook informatie over milieudoelstellingen, scenario's en beleidsopties en - maatregelen, inclusief de kosten en baten hiervan. Dit rapport is het technische achtergrondrapport dat behoort bij het hoofdrapport. Er zijn twaalf technische achtergrondrapporten opgesteld, waarvan negen een specifiek milieuprobleem behandelen (analyse van het probleem, scenarios, kosten-batenanalyse en beleidsopties). Daarnaast zijn er d, The economic assessment of priorities for a European environmental policy plan focuses on twelve identified Prominent European Environmental Problems such as climate change, chemical risks and biodiversity. The study, commissioned by the European Commission (DG Environment) to a European consortium led by RIVM, provides a basis for priority setting for European environmental policy planning in support of the sixth Environmental Action Programme as follow-up of the current fifth Environmental Action Plan called 'Towards Sustainability'. The analysis is based on an examination of the cost of avoided damage, environmental expenditures, risk assessment, public opinion, social incidence and sustainability. The study incorporates information on targets, scenario results, and policy options and measures including their costs and benefits. Main findings of the study are the following. Current trends show that if all existing policies are fully implemented and enforced, the European Union will be successful in reducing pressures on the environment. However, damage to human health and ecosystems can be substantially reduced with accelerated policies. The implementation costs of these additional policies will not exceed the environmental benefits and the impact on the economy is manageable. This requires future policies to focus on least-cost solutions and follow an integrated approach. Nevertheless, these policies will not be adequate for achieving all policy objectives. Remaining major problems are the excess load of nitrogen in the ecosystem, exceedance of air quality guidelines (especially particulate matter), noise nuisance and biodiversity loss. This report is one of a series supporting the main report: European Environmental Priorities: an Integrated Economic and Environmental Assessment. The areas discussed in the main report are fully documented in the various Technical reports. A background report is presented for each environmental issue giving an outline of the pro

Published
2001

47. Recent Studies on the Rhizobium-legume symbiosis

Author

Dazzo, F., Hollingsworth, R., Philip Hollingsworth, S., Squartini, Andrea, Chapman, K., Cargill, L., Salzwedel, J., Petersen, M., Pankratz, S., Orgambide, G., De Troch, P., Olen, T., Baker, D. Maya Flores J., Aggarwall, A., and Hollander, G.

Published
1990

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