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943 results on '"Holland, Edward J."'

6. Reply

Author

Holland, Edward J., primary, Cheung, Albert Y., additional, and Djalilian, Ali R., additional

Published
2023
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13. Corneal Graft Rejection 10 Years After Penetrating Keratoplasty in the Cornea Donor Study

Author

Dunn, Steven P, Gal, Robin L, Kollman, Craig, Raghinaru, Dan, Dontchev, Mariya, Blanton, Christopher L, Holland, Edward J, Lass, Jonathan H, Kenyon, Kenneth R, Mannis, Mark J, Mian, Shahzad I, Rapuano, Christopher J, Stark, Walter J, and Beck, Roy W

Subjects
Organ Transplantation, Eye Disease and Disorders of Vision, Neurodegenerative, Clinical Research, Transplantation, Rare Diseases, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Eye, Aged, Allografts, Corneal Edema, Follow-Up Studies, Fuchs' Endothelial Dystrophy, Graft Rejection, Graft Survival, Humans, Incidence, Keratoplasty, Penetrating, Middle Aged, Postoperative Complications, Risk Factors, Tissue Donors, Transplant Recipients, corneal graft rejection, penetrating keratoplasty, corneal graft failure, Writing Committee for the Cornea Donor Study Research Group, Clinical Sciences, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

PurposeThe aim of this study was to assess the effect of donor and recipient factors on corneal allograft rejection and evaluate whether a rejection event was associated with graft failure.MethodsOne thousand ninety subjects undergoing penetrating keratoplasty for a moderate risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) were followed for up to 12 years. Associations of baseline recipient and donor factors with the occurrence of a rejection event were assessed in univariate and multivariate proportional hazards models.ResultsAmong 651 eyes with a surviving graft at 5 years, the 10-year graft failure (±99% confidence interval) rates were 12% ± 4% among eyes with no rejection events in the first 5 years, 17% ± 12% in eyes with at least 1 probable, but no definite rejection event, and 22% ± 20% in eyes with at least 1 definite rejection event. The only baseline factor significantly associated with a higher risk of definite graft rejection was a preoperative history of glaucoma, particularly when previous glaucoma surgery had been performed and glaucoma medications were being used at the time of transplant (10-year incidence 35% ± 23% compared with 14% ± 4% in eyes with no history of glaucoma/intraocular pressure treatment, P = 0.008).ConclusionsPatients who experienced a definite rejection event frequently developed graft failure raising important questions as to how we might change acute and long-term corneal graft management. Multivariate analysis indicated that previous use of glaucoma medications and glaucoma filtering surgery was a significant risk factor related to a definite rejection event.

Published
2014

15. Donor Age and Factors Related to Endothelial Cell Loss 10 Years after Penetrating Keratoplasty Specular Microscopy Ancillary Study

Author

Group, Writing Committee for the Cornea Donor Study Research, Lass, Jonathan H, Benetz, Beth Ann, Gal, Robin L, Kollman, Craig, Raghinaru, Dan, Dontchev, Mariya, Mannis, Mark J, Holland, Edward J, Chow, Christopher, McCoy, Kristen, Price, Francis W, Sugar, Alan, Verdier, David D, and Beck, Roy W

Subjects
Transplantation, Clinical Trials and Supportive Activities, Eye Disease and Disorders of Vision, Clinical Research, Eye, Adolescent, Adult, Aged, Aging, Cell Count, Child, Corneal Edema, Corneal Endothelial Cell Loss, Double-Blind Method, Endothelium, Corneal, Eye Banks, Female, Fuchs' Endothelial Dystrophy, Graft Survival, Humans, Keratoplasty, Penetrating, Male, Middle Aged, Postoperative Complications, Prospective Studies, Risk Factors, Time Factors, Tissue Donors, Young Adult, Writing Committee for the Cornea Donor Study Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo examine the effect of donor age and other perioperative factors on long-term endothelial cell loss after penetrating keratoplasty (PKP).DesignMulticenter, prospective, double-masked clinical trial.ParticipantsWe included 176 participants from the Cornea Donor Study cohort who had not experienced graft failure ≥ 10 years after PKP for a moderate risk condition (principally Fuchs' dystrophy or pseudophakic/aphakic corneal edema).MethodsCorneas from donors 12 to 75 years old were assigned to participants using a randomized approach, without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines. Images of the central endothelium were obtained preoperatively and at intervals for 10 years postoperatively. Images were analyzed by a central image analysis reading center to determine endothelial cell density (ECD).Main outcome measuresEndothelial cell density at 10 years.ResultsAmong study participants with a clear graft at 10 years, the 125 who received a cornea from a donor 12 to 65 years old experienced a median cell loss of 76%, resulting in a 10-year median ECD of 628 cells/mm(2) (interquartile range [IQR], 522-850 cells/mm(2)), whereas the 51 who received a cornea from a donor 66 to 75 years old experienced a cell loss of 79%, resulting in a median 10-year ECD of 550 cells/mm(2) (IQR, 483-694 cells/mm(2); P adjusted for baseline ECD = 0.03). In addition to younger donor age, higher ECD values were significantly associated with higher baseline ECD (P1000 cells/mm(2).ConclusionsSubstantial cell loss occurs in eyes with a clear graft 10 years after PKP, with the rate of cell loss being slightly greater with older donor age. Greater preoperative ECD and larger donor tissue size are associated with higher ECD at 10 years.

Published
2013

16. The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease Graft Survival after 10 Years in the Cornea Donor Study

Author

Group, Writing Committee for the Cornea Donor Study Research, Mannis, Mark J, Holland, Edward J, Gal, Robin L, Dontchev, Mariya, Kollman, Craig, Raghinaru, Dan, Dunn, Steven P, Schultze, Robert L, Verdier, David D, Lass, Jonathan H, Raber, Irving M, Sugar, Joel, Gorovoy, Mark S, Sugar, Alan, Stulting, R Doyle, Montoya, Monty M, Penta, Jeffrey G, Benetz, Beth Ann, and Beck, Roy W

Subjects
Eye Disease and Disorders of Vision, Clinical Trials and Supportive Activities, Transplantation, Clinical Research, Eye, Adolescent, Adult, Age Factors, Aged, Aging, Child, Corneal Edema, Double-Blind Method, Eye Banks, Female, Follow-Up Studies, Fuchs' Endothelial Dystrophy, Graft Survival, Humans, Keratoplasty, Penetrating, Male, Middle Aged, Prospective Studies, Registries, Tissue Donors, Young Adult, Writing Committee for the Cornea Donor Study Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.DesignMulticenter, prospective, double-masked clinical trial.ParticipantsA total of 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs' dystrophy (62%), pseudophakic/aphakic corneal edema (34%), or another corneal endothelial disorder (4%) and followed for up to 12 years.MethodsForty-three eye banks provided corneas from donors aged 12 to 75 years, using a randomized approach to assign donor corneas to study participants without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines.Main outcome measuresGraft failure defined as a regraft or, in the absence of a regraft, a cloudy cornea that was sufficiently opaque to compromise vision for 3 consecutive months.ResultsIn the primary analysis, the 10-year success rate was 77% for 707 corneas from donors aged 12 to 65 years compared with 71% for 383 donors aged 66 to 75 years (difference, +6%; 95% confidence interval, -1 to +12; P = 0.11). When analyzed as a continuous variable, higher donor age was associated with lower graft success beyond the first 5 years (P

Published
2013

26. Reply

Author

Sarnicola, Enrica, Sarnicola, Caterina, Cheung, Albert Y., Holland, Edward J., and Sarnicola, Vincenzo

Published
2019
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29. Reply

Author

Cheung, Albert Y., Kurji, Khaliq H., Nordlund, Michael L., and Holland, Edward J.

Published
2018
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40. Keratolimbal Allograft

Author

Schwartz, Gary S., Tsubota, Kazuo, Tseng, Scheffer C.G., Mannis, Mark J., Holland, Edward J., Holland, Edward J., and Mannis, Mark J.

Published
2002
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