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268 results on '"Holland, David J"'

3. Antiviral agents

Author

Holland, David J, Dwyer, Dominic E, and Cunningham, Anthony L

Published
1995

8. Coronary artery fistula following surgical myectomy for hypertrophic obstructive cardiomyopathy: a case report.

Author

Bowles, James, Martin, Joshua, Russell, Penni L, Bailey, Amy, and Holland, David J

Subjects
HYPERTROPHIC cardiomyopathy, CORONARY arteries, MYOMECTOMY, FISTULA, AORTIC valve insufficiency, MUCOCUTANEOUS lymph node syndrome, CORONARY angiography
Abstract

Background Coronary artery fistula is a rare, but recognized complication of surgical myectomy. Although most communicate with the right heart, a large fistula into the left ventricular cavity may result in a shunt haemodynamically analogous to aortic regurgitation. Understanding the variable presentation of iatrogenic coronary fistulae and the optimal evaluation strategy is critical to obtaining a timely diagnosis and instituting treatment. Case summary We report the case of a 57-year-old renal transplant recipient admitted for evaluation of presyncope, one-year post-surgical myectomy for hypertrophic obstructive cardiomyopathy. An iatrogenic coronary artery fistula was suspected by transthoracic echocardiography, and later confirmed with both non-invasive and invasive coronary angiography. Discussion We highlight various cardiac imaging modalities that confirmed the diagnosis of coronary artery fistula and helped to determine the clinical significance. We report the tailored approach often required to determine the anatomic and haemodynamic characteristics of coronary fistulae and outline potential management strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Accuracy of dual-energy x-ray absorptiometry for assessing longitudinal change in visceral adipose tissue in patients with coronary artery disease

Author

Taylor, Jenna L., Holland, David J., Coombes, Jeff S., and Keating, Shelley E.

Abstract

Background/Objective: Visceral adipose tissue (VAT) is a key target of interventions for obesity-related diseases. Dual-energy x-ray absorptiometry (DXA) can estimate VAT, however its accuracy to measure longitudinal change in VAT compared to gold-standard techniques such as magnetic resonance imaging (MRI), has not been studied in adults. This study aimed to determine the accuracy of DXA compared with gold-standard MRI for cross-sectional VAT assessment, and for detecting longitudinal change in VAT. Methods: Adults with coronary artery disease (64 ± 8 years; BMI 27.8 ± 3.5 kg/m2; 88% male) were assessed for VAT by DXA and MRI at baseline (n= 34) and during implementation of an exercise intervention study at 3- and 12-months (n= 29). To match the 5.2 cm DXA measurement site for Hologic software (InnerCoreTM), VAT cross-sectional area (CSA) was measured by MRI using a single slice at L4/L5 junction, and VAT volume measured by 10 × 5 mm slices over the L4/L5 junction. MRI slices were quantified for VAT using semi-automated specialised software. Relationships between DXA and MRI for cross-sectional VAT and longitudinal change in VAT were determined by linear regression. Accuracy between the methods was assessed by Bland–Altman analysis, with data presented as mean difference (95% confidence interval), lower and upper limits of agreement (LoA). Results: Strong correlations were found between DXA-VAT and MRI-VAT at baseline (r= 0.90; p< 0.001), and longitudinal change in DXA-VAT and MRI-VAT over 3- and 12-months (r= 0.67; p< 0.001). In contrast, Bland–Altman analysis revealed significant overestimation by DXA-VAT volume at baseline by 13% [−104 cm3(−157, −52 cm3), p< 0.001; LoA (−398, 189 cm3)], and underestimation of change in DXA-VAT volume over 3-months by 33% [−41 cm3(−77, −4 cm3), p= 0.030; LoA (−228, 147 cm3)] and 12-months by 47% [−65 cm3(−114, −17 cm3), p= 0.010; LoA (−316, 185 cm3)]. Results were similar for VAT CSA. Conclusions: Compared with MRI, DXA substantially underestimated longitudinal changes in VAT. Therefore, DXA is not currently a valid alternative to MRI for quantifying VAT changes and may under-represent the effectiveness of interventions for obesity management.

Published
2024
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26. Heart failure with preserved ejection fraction: An exclusive diagnosis.

Author

HOLLAND, DAVID J., BLAZAK, PENNI L., ATHERTON, JOHN J., and PRASAD, SANDHIR

Subjects
*VENTRICULAR ejection fraction, *HEART failure, *EARLY diagnosis, *DIAGNOSIS, *ECHOCARDIOGRAPHY, *SYMPTOMS
Abstract

Heart failure with preserved ejection fraction is common but difficult to diagnose. Echocardiography can identify structural and functional cardiac disease and may help determine an alternative cause. Exercise echocardiography can help confirm the diagnosis. GPs play an important role in facilitating early diagnosis and excluding alternative causes for symptoms. [ABSTRACT FROM AUTHOR]

Published
2023

27. Multimodality cardiac imaging in iatrogenic coronary artery fistula - author's response to: "Insights and observations on post-septal myectomy coronary cameral fistula".

Author

Bowles, James, Martin, Joshua, and Holland, David J

Subjects
VENTRICULAR outflow obstruction, CARDIAC imaging, MYOMECTOMY, CORONARY arteries, FISTULA, IATROGENIC diseases, STRESS echocardiography, INTRAVASCULAR ultrasonography
Abstract

The article focuses on the use of multimodal cardiac imaging in diagnosing iatrogenic coronary artery fistulas after surgical myectomy. Topics include the importance of surgical myectomy in hypertrophic cardiomyopathy, the role of advanced imaging techniques like photon-counting computed tomography, and the clinical significance of detecting coronary fistulas, particularly in post-operative patients.

Published
2024
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29. Additional file 4 of Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity

Author

Wilson, Brooke C., Vatanen, Tommi, Thilini N. Jayasinghe, Leong, Karen S. W., Derraik, José G. B., Albert, Benjamin B., Chiavaroli, Valentina, Svirskis, Darren M., Beck, Kathryn L., Conlon, Cathryn A., Yannan Jiang, Schierding, William, Holland, David J., Cutfield, Wayne S., and O’Sullivan, Justin M.

Abstract

Additional file 3. Supplementary Table 2

Published
2021
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30. Additional file 5 of Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity

Author

Wilson, Brooke C., Vatanen, Tommi, Thilini N. Jayasinghe, Leong, Karen S. W., Derraik, José G. B., Albert, Benjamin B., Chiavaroli, Valentina, Svirskis, Darren M., Beck, Kathryn L., Conlon, Cathryn A., Yannan Jiang, Schierding, William, Holland, David J., Cutfield, Wayne S., and O’Sullivan, Justin M.

Abstract

Additional file 4. Supplementary Table 3

Published
2021
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31. Additional file 3 of Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity

Author

Wilson, Brooke C., Vatanen, Tommi, Thilini N. Jayasinghe, Leong, Karen S. W., Derraik, José G. B., Albert, Benjamin B., Chiavaroli, Valentina, Svirskis, Darren M., Beck, Kathryn L., Conlon, Cathryn A., Yannan Jiang, Schierding, William, Holland, David J., Cutfield, Wayne S., and O’Sullivan, Justin M.

Abstract

Additional file 2. Supplementary Table 1

Published
2021
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34. Effects of Fecal Microbiome Transfer in Adolescents With Obesity The Gut Bugs Randomized Controlled Trial

Author

Leong, Karen S. W., Jayasinghe, Thilini N., Wilson, Brooke C., Derraik, José G. B., Albert, Benjamin B., Chiavaroli, Valentina, Svirskis, Darren M., Beck, Kathryn L., Conlon, Cathryn A., Jiang, Yannan, Schierding, William, Vatanen, Tommi, Holland, David J., O'Sullivan, Justin M., Cutfield, Wayne S., Leong, Karen S. W., Jayasinghe, Thilini N., Wilson, Brooke C., Derraik, José G. B., Albert, Benjamin B., Chiavaroli, Valentina, Svirskis, Darren M., Beck, Kathryn L., Conlon, Cathryn A., Jiang, Yannan, Schierding, William, Vatanen, Tommi, Holland, David J., O'Sullivan, Justin M., and Cutfield, Wayne S.

Abstract

Importance Treatment of pediatric obesity is challenging. Preclinical studies in mice indicated that weight and metabolism can be altered by gut microbiome manipulation. Objective To assess efficacy of fecal microbiome transfer (FMT) to treat adolescent obesity and improve metabolism. Design, Setting, and Participants This randomized, double-masked, placebo-controlled trial (October 2017-March 2019) with a 26-week follow-up was conducted among adolescents aged 14 to 18 years with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 30 or more in Auckland, New Zealand. A total of 87 individuals took part-565 individuals responded to advertisements, 328 were ineligible, and 150 declined participation. Clinical data were analyzed from September 2019 to May 2020. Interventions Single course of oral encapsulated fecal microbiome from 4 healthy lean donors of the same sex or saline placebo. Main Outcomes and Measures Primary outcome was BMI standard deviation score at 6 weeks using intention-to-treat analysis. Secondary outcomes included body composition, cardiometabolic parameters, well-being, and gut microbiome composition. Results Eighty-seven participants (59% female adolescents, mean [SD] age 17.2 [1.4] years) were randomized 1:1, in groups stratified by sex, to FMT (42 participants) or placebo (45 participants). There was no effect of FMT on BMI standard deviation score at 6 weeks (adjusted mean difference [aMD] -0.026; 95% CI -0.074, 0.022). Reductions in android-to-gynoid-fat ratio in the FMT vs placebo group were observed at 6, 12, and 26 weeks, with aMDs of -0.021 (95% CI, -0.041 to -0.001), -0.023 (95% CI, -0.043 to -0.003), and -0.029 (95% CI, -0.049 to -0.008), respectively. There were no observed effects on insulin sensitivity, liver function, lipid profile, inflammatory markers, blood pressure, total body fat percentage, gut health, and health-related quality of life. Gut microbiome profiling revealed a shift in

Published
2020
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36. Effects of Fecal Microbiome Transfer in Adolescents With Obesity

Author

Leong, Karen S. W., primary, Jayasinghe, Thilini N., additional, Wilson, Brooke C., additional, Derraik, José G. B., additional, Albert, Benjamin B., additional, Chiavaroli, Valentina, additional, Svirskis, Darren M., additional, Beck, Kathryn L., additional, Conlon, Cathryn A., additional, Jiang, Yannan, additional, Schierding, William, additional, Vatanen, Tommi, additional, Holland, David J., additional, O’Sullivan, Justin M., additional, and Cutfield, Wayne S., additional

Published
2020
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38. Comparison of high intensity interval training with standard cardiac rehabilitation on vascular function.

Author

Taylor, Jenna L., Keating, Shelley E., Holland, David J., Green, Daniel J., Coombes, Jeff S., and Bailey, Tom G.

Subjects
BRACHIAL artery, CONFIDENCE intervals, EXERCISE physiology, ARTERIAL diseases, RANDOMIZED controlled trials, VASODILATION, CARDIAC rehabilitation, CORONARY artery disease, DESCRIPTIVE statistics, HIGH-intensity interval training, STATISTICAL sampling, BLOOD pressure measurement
Abstract

Objectives: To compare the short‐ and long‐term effects of high‐intensity interval training (HIIT) with usual care moderate intensity continuous training (MICT) on systemic vascular function and stiffness in patients with coronary artery disease undergoing a cardiac rehabilitation program. Design: Randomized controlled trial. Methods: Fifty‐four patients (age = 63 ± 8 years, 93% male) were randomized to complete 3 sessions/week (2 supervised, 1 home‐based) of either (1) 4 × 4‐min HIIT or (2) 40‐min MICT, for 4 weeks. Patients then continued 3 unsupervised home‐based sessions/week of their allocated training for 11 months. Brachial artery flow‐mediated dilation, pulse wave velocity, and blood pressure were measured at baseline, 4 weeks, 3 months, 6 months, and 12 months. Data were analyzed using linear mixed modeling and are presented as mean change from baseline (95% CI). Results: HIIT showed a greater improvement in flow‐mediated dilation compared to MICT after 4 weeks [1.5% (0.9, 2.1) vs 0.1% (−0.5, 0.8); p = 0.004) but not 12 months [1.2% (−0.2, 2.5) vs 0.4% (−0.8, 1.7); p = 0.153). There were no short‐ or long‐term group differences for changes in pulse wave velocity, peripheral or central blood pressure between HIIT and MICT after 4 weeks, or over 12 months. Conclusions: A 4‐week HIIT program was superior to MICT for improving vascular function, but not arterial stiffness or blood pressure. Over 12 months, changes in vascular function, blood pressure, and arterial stiffness were similar for HIIT and MICT. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis–Prospective Cohort Study

Author

Murdoch, David R., Corey, Ralph G., Hoen, Bruno, Miró, José M., Fowler, Vance G., Jr, Bayer, Arnold S., Karchmer, Adolf W., Olaison, Lars, Pappas, Paul A., Moreillon, Philippe, Chambers, Stephen T., Chu, Vivian H., Falcó, Vicenç, Holland, David J., Jones, Philip, Klein, John L., Raymond, Nigel J., Read, Kerry M., Tripodi, Marie Francoise, Utili, Riccardo, Wang, Andrew, Woods, Christopher W., and Cabell, Christopher H.

Published
2009
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48. The Chronic Effect of Interval Training on Energy Intake: A Systematic Review and Meta-Analysis

Author

Taylor, Jenna, Keating, Shelley E., Holland, David J., Coombes, Jeff S., and Leveritt, Michael D.

Subjects
Article Subject
Abstract

Single bouts of acute exercise do not appear to increase subsequent energy intake (EI), even when energy deficit is large. However, studies have shown a compensatory effect on EI following chronic exercise, and it remains unclear whether this is affected by exercise intensity. We investigated the chronic effect of high-intensity interval training (HIIT) and sprint interval training (SIT) on EI when compared with moderate-intensity continuous training (MICT) or no exercise (CON). Databases were searched until 13 March 2017 for studies measuring EI in response to chronic exercise (≥4 weeks of duration) of a high-intensity interval nature. Meta-analysis was conducted for between-group comparisons on EI (kilojoules) and bodyweight (kg). Results showed large heterogeneity, and therefore, metaregression analyses were conducted. There were no significant differences in EI between HIIT/SIT versus MICT (P=0.282), HIIT/SIT versus CON (P=0.398), or MICT versus CON (P=0.329). Although bodyweight was significantly reduced after HIIT/SIT versus CON but not HIIT/SIT versus MICT (in studies measuring EI), this was not clinically meaningful (

Published
2018
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