Author: "Holbrook, B" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Holbrook, B"' showing total 234 results

Start Over Author "Holbrook, B"

234 results on '"Holbrook, B"'

1. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunhaw, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., and Zarzhitsky, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $1.4 \times 10^{-48}$ cm$^{2}$ for a WIMP mass of 40 GeV/c$^{2}$ and a 1000 d exposure. LZ achieves this sensitivity through a combination of a large 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented., Comment: 45 pages (79 inc. tables), 7 figures, 9 tables
Published: 2020
Full Text: View/download PDF

2. The LUX-ZEPLIN (LZ) Experiment

Author: The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements.
Published: 2019
Full Text: View/download PDF

3. Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author: Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G.-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K.A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Ding, Wern Yew, Kotalczyk, Agnieszka, Boriani, Giuseppe, Marin, Francisco, Blomström-Lundqvist, Carina, Potpara, Tatjana S., Fauchier, Laurent, and Lip, Gregory.Y.H.
Published: 2022
Full Text: View/download PDF

4. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry

Author: Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M.R., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Lane, D., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Vitolo, Marco, Malavasi, Vincenzo L., Proietti, Marco, Diemberger, Igor, Fauchier, Laurent, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana S., Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo Pietro, Lane, Deirdre A., Lip, Gregory Y.H., and Boriani, Giuseppe
Published: 2022
Full Text: View/download PDF

5. LUX-ZEPLIN (LZ) Technical Design Report

Author: Mount, B. J., Hans, S., Rosero, R., Yeh, M., Chan, C., Gaitskell, R. J., Huang, D. Q., Makkinje, J., Malling, D. C., Pangilinan, M., Rhyne, C. A., Taylor, W. C., Verbus, J. R., Kim, Y. D., Lee, H. S., Lee, J., Leonard, D. S., Li, J., Belle, J., Cottle, A., Lippincott, W. H., Markley, D. J., Martin, T. J., Sarychev, M., Tope, T. E., Utes, M., Wang, R., Young, I., Araújo, H. M., Bailey, A. J., Bauer, D., Colling, D., Currie, A., Fayer, S., Froborg, F., Greenwood, S., Jones, W. G., Kasey, V., Khaleeq, M., Olcina, I., Paredes, B. López, Richards, A., Sumner, T. J., Tomás, A., Vacheret, A., Brás, P., Lindote, A., Lopes, M. I., Neves, F., Rodrigues, J. P., Silva, C., Solovov, V. N., Barry, M. J., Cole, A., Dobi, A., Edwards, W. R., Faham, C. H., Fiorucci, S., Gantos, N. J., Gehman, V. M., Gilchriese, M. G. D., Hanzel, K., Hoff, M. D., Kamdin, K., Lesko, K. T., McConnell, C. T., O'Sullivan, K., Oliver-Mallory, K. C., Patton, S. J., Saba, J. S., Sorensen, P., Thomas, K. J., Tull, C. E., Waldron, W. L., Witherell, M. S., Bernstein, A., Kazkaz, K., Xu, J., Akimov, D. Yu., Bolozdynya, A. I., Khromov, A. V., Konovalov, A. M., Kumpan, A. V., Sosnovtsev, V. V., Dahl, C. E., Temples, D., Carmona-Benitez, M. C., de Viveiros, L., Akerib, D. S., Auyeung, H., Biesiadzinski, T. P., Breidenbach, M., Bramante, R., Conley, R., Craddock, W. W., Fan, A., Hau, A., Ignarra, C. M., Ji, W., Krebs, H. J., Linehan, R., Lee, C., Luitz, S., Mizrachi, E., Monzani, M. E., O'Neill, F. G., Pierson, S., Racine, M., Ratcliff, B. N., Shutt, G. W., Shutt, T. A., Skarpaas, K., Stifter, K., To, W. H., Va'vra, J., Whitis, T. J., Wisniewski, W. J., Bai, X., Bunker, R., Coughlen, R., Hjemfelt, C., Leonard, R., Miller, E. H., Morrison, E., Reichenbacher, J., Schnee, R. W., Stark, M. R., Sundarnath, K., Tiedt, D. R., Timalsina, M., Bauer, P., Carlson, B., Horn, M., Johnson, M., Keefner, J., Maupin, C., Taylor, D. J., Balashov, S., Ford, P., Francis, V., Holtom, E., Khazov, A., Kaboth, A., Majewski, P., Nikkel, J. A., O'Dell, J., Preece, R. M., van der Grinten, M. G. D., Worm, S. D., Mannino, R. L., Stiegler, T. M., Terman, P. A., Webb, R. C., Levy, C., Mock, J., Szydagis, M., Busenitz, J. K., Elnimr, M., Hor, J. Y-K., Meng, Y., Piepke, A., Stancu, I., Kreczko, L., Krikler, B., Penning, B., Bernard, E. P., Jacobsen, R. G., McKinsey, D. N., Watson, R., Cutter, J. E., El-Jurf, S., Gerhard, R. M., Hemer, D., Hillbrand, S., Holbrook, B., Lenardo, B. G., Manalaysay, A. G., Morad, J. A., Stephenson, S., Thomson, J. A., Tripathi, M., Uvarov, S., Haselschwardt, S. J., Kyre, S., Nehrkorn, C., Nelson, H. N., Solmaz, M., White, D. T., Cascella, M., Dobson, J. E. Y., Ghag, C., Liu, X., Manenti, L., Reichhart, L., Shaw, S., Utku, U., Beltrame, P., Davison, T. J. R., Marzioni, M. F., Murphy, A. St. J., Nilima, A., Boxer, B., Burdin, S., Greenall, A., Powell, S., Rose, H. J., Sutcliffe, P., Balajthy, J., Edberg, T. K., Hall, C. R., Silk, J. S., Hertel, S., Akerlof, C. W., Arthurs, M., Lorenzon, W., Pushkin, K., Schubnell, M., Boast, K. E., Carels, C., Fruth, T., Kraus, H., Liao, F. -T., Lin, J., Scovell, P. R., Druszkiewicz, E., Khaitan, D., Koyuncu, M., Skulski, W., Wolfs, F. L. H., Yin, J., Korolkova, E. V., Kudryavtsev, V. A., Rossiter, P., Woodward, D., Chiller, A. A., Chiller, C., Mei, D. -M., Wang, L., Wei, W. -Z., While, M., Zhang, C., Alsum, S. K., Benson, T., Carlsmith, D. L., Cherwinka, J. J., Dasu, S., Gregerson, G., Gomber, B., Pagac, A., Palladino, K. J., Vuosalo, C. O., Xiao, Q., Buckley, J. H., Bugaev, V. V., Olevitch, M. A., Boulton, E. M., Emmet, W. T., Hurteau, T. W., Larsen, N. A., Pease, E. K., Tennyson, B. P., and Tvrznikova, L.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: In this Technical Design Report (TDR) we describe the LZ detector to be built at the Sanford Underground Research Facility (SURF). The LZ dark matter experiment is designed to achieve sensitivity to a WIMP-nucleon spin-independent cross section of three times ten to the negative forty-eighth square centimeters., Comment: 392 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Numbers Two and Three (CD-2 and CD-3) management processes. Report also available by chapter at this URL
Published: 2017

6. Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches

Author: Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alsum, S. K., Araújo, H. M., Arnquist, I. J., Arthurs, M., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Barry, M. J., Belle, J., Beltrame, P., Benson, T., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boast, K. E., Bolozdynya, A., Boxer, B., Bramante, R., Brás, P., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Cottle, A., Coughlen, R., Craddock, W. W., Currie, A., Dahl, C. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edberg, T. K., Edwards, W. R., Emmet, W. T., Faham, C. H., Fiorucci, S., Fruth, T., Gaitskell, R. J., Gantos, N. J., Gehman, V. M., Gerhard, R. M., Ghag, C., Gilchriese, M. G. D., Gomber, B., Hall, C. R., Hans, S., Hanzel, K., Haselschwardt, S. J., Hertel, S. A., Hillbrand, S., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hoppe, E. W., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kaboth, A., Kamdin, K., Kazkaz, K., Khaitan, D., Khazov, A., Khromov, A. V., Konovalov, A. M., Korolkova, E. V., Koyuncu, M., Kraus, H., Krebs, H. J., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lee, C., Lee, H. S., Lee, J., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Liao, F. -T., Lin, J., Lindote, A., Linehan, R. E., Lippincott, W. H., Liu, X., Lopes, M. I., Paredes, B. Lopez, Lorenzon, W., Luitz, S., Majewski, P., Manalaysay, A., Manenti, L., Mannino, R. L., Markley, D. J., Martin, T. J., Marzioni, M. F., McConnell, C. T., McKinsey, D. N., Mei, D. -M., Meng, Y., Miller, E. H., Mizrachi, E., Mock, J., Monzani, M. E., Morad, J. A., Mount, B. J., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., Nikkel, J. A., O'Dell, J., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Piepke, A., Powell, S., Preece, R. M., Pushkin, K., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Saba, J. S., Sarychev, M., Schnee, R. W., Schubnell, M., Scovell, P. R., Shaw, S., Shutt, T. A., Silva, C., Skarpaas, K., Skulski, W., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stiegler, T. M., Stifter, K., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Temples, D., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tvrznikova, L., Va'vra, J., Vacheret, A., van der Grinten, M. G. D., Verbus, J. R., Vuosalo, C. O., Waldron, W. L., Wang, R., Watson, R., Webb, R. C., Wei, W. -Z., While, M., White, D. T., Whitis, T. J., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Woodward, D., Worm, S., Xu, J., Yeh, M., Yin, J., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of $^{238}$U$_{e}$~$<$1.6~mBq/kg, $^{238}$U$_{l}$~$<$0.09~mBq/kg, $^{232}$Th$_{e}$~$=0.28\pm 0.03$~mBq/kg, $^{232}$Th$_{l}$~$=0.25\pm 0.02$~mBq/kg, $^{40}$K~$<$0.54~mBq/kg, and $^{60}$Co~$<$0.02~mBq/kg (68\% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of $0.160\pm0.001$(stat)$\pm0.030$(sys) counts., Comment: 13 pages, 3 figures, accepted for publication in Astroparticle Physics
Published: 2017
Full Text: View/download PDF

7. Identification of radiopure titanium for the LZ dark matter experiment and future rare event searches

Author: Akerib, DS, Akerlof, CW, Akimov, DY, Alsum, SK, Araújo, HM, Arnquist, IJ, Arthurs, M, Bai, X, Bailey, AJ, Balajthy, J, Balashov, S, Barry, MJ, Belle, J, Beltrame, P, Benson, T, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boast, KE, Bolozdynya, A, Boxer, B, Bramante, R, Brás, P, Buckley, JH, Bugaev, VV, Bunker, R, Burdin, S, Busenitz, JK, Carels, C, Carlsmith, DL, Carlson, B, Carmona-Benitez, MC, Chan, C, Cherwinka, JJ, Chiller, AA, Chiller, C, Cottle, A, Coughlen, R, Craddock, WW, Currie, A, Dahl, CE, Davison, TJR, Dobi, A, Dobson, JEY, Druszkiewicz, E, Edberg, TK, Edwards, WR, Emmet, WT, Faham, CH, Fiorucci, S, Fruth, T, Gaitskell, RJ, Gantos, NJ, Gehman, VM, Gerhard, RM, Ghag, C, Gilchriese, MGD, Gomber, B, Hall, CR, Hans, S, Hanzel, K, Haselschwardt, SJ, Hertel, SA, Hillbrand, S, Hjemfelt, C, Hoff, MD, Holbrook, B, Holtom, E, Hoppe, EW, Hor, JYK, Horn, M, Huang, DQ, Hurteau, TW, Ignarra, CM, Jacobsen, RG, Ji, W, Kaboth, A, Kamdin, K, Kazkaz, K, Khaitan, D, Khazov, A, Khromov, AV, Konovalov, AM, Korolkova, EV, Koyuncu, M, Kraus, H, Krebs, HJ, Kudryavtsev, VA, Kumpan, AV, Kyre, S, Lee, C, Lee, HS, Lee, J, Leonard, DS, Leonard, R, Lesko, KT, Levy, C, Liao, FT, Lin, J, and Lindote, A
Subjects: physics.ins-det, hep-ex, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract: The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of 238Ue < 1.6 mBq/kg, 238Ul < 0.09 mBq/kg, 232The=0.28±0.03 mBq/kg, 232Thl=0.25±0.02 mBq/kg, 40K < 0.54 mBq/kg, and 60Co < 0.02 mBq/kg (68% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of 0.160 ± 0.001(stat) ± 0.030(sys) counts.
Published: 2017

8. LUX-ZEPLIN (LZ) Conceptual Design Report

Author: The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alsum, S. K., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Barry, M. J., Bauer, P., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Bramante, R., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Craddock, W. W., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dasu, S., Davison, T. J. R., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edberg, T. K., Edwards, B. N., Edwards, W. R., Elnimr, M. M., Emmet, W. T., Faham, C. H., Fiorucci, S., Ford, P., Francis, V. B., Fu, C., Gaitskell, R. J., Gantos, N. J., Gehman, V. M., Gerhard, R. M., Ghag, C., Gilchriese, M. G. D., Gomber, B., Hall, C. R., Harris, A., Haselschwardt, S. J., Hertel, S. A., Hoff, M. D., Holbrook, B., Holtom, E., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Jacobsen, R. G., Ji, W., Ji, X., Johnson, M., Ju, Y., Kamdin, K., Kazkaz, K., Khaitan, D., Khazov, A., Khromov, A. V., Konovalov, A. M., Korolkova, E. V., Kraus, H., Krebs, H. J., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Liao, F. -T., Lin, J., Lindote, A., Lippincott, W. H., Liu, J., Liu, X., Lopes, M. I., Lorenzon, W., Luitz, S., Majewski, P., Malling, D. C., Manalaysay, A. G., Manenti, L., Mannino, R. L., Markley, D. J., Martin, T. J., Marzioni, M. F., McKinsey, D. N., Mei, D. -M., Meng, Y., Miller, E. H., Mock, J., Monzani, M. E., Morad, J. A., Murphy, A. St. J., Nelson, H. N., Neves, F., Nikkel, J. A., O'Neill, F. G., O'Dell, J., O'Sullivan, K., Olevitch, M. A., Oliver-Mallory, K. C., Palladino, K. J., Pangilinan, M., Patton, S. J., Pease, E. K., Piepke, A., Powell, S., Preece, R. M., Pushkin, K., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C., Rodrigues, J. P., Rose, H. J., Rosero, R., Saba, J. S., Sarychev, M., Schnee, R. W., Schubnell, M. S. G., Scovell, P. R., Shaw, S., Shutt, T. A., Silva, C., Skarpaas, K., Skulski, W., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stiegler, T. M., Sumner, T. J., Sundarnath, K., Szydagis, M., Taylor, D. J., Taylor, W., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., To, W. H., Tomás, A., Tripathi, M., Tull, C. E., Tvrznikova, L., Uvarov, S., Va'vra, J., van der Grinten, M. G. D., Verbus, J. R., Vuosalo, C. O., Waldron, W. L., Wang, L., Webb, R. C., Wei, W. -Z., While, M., White, D. T., Whitis, T. J., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Woods, E., Woodward, D., Worm, S. D., Yeh, M., Yin, J., Young, S. K., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: The design and performance of the LUX-ZEPLIN (LZ) detector is described as of March 2015 in this Conceptual Design Report. LZ is a second-generation dark-matter detector with the potential for unprecedented sensitivity to weakly interacting massive particles (WIMPs) of masses from a few GeV/c2 to hundreds of TeV/c2. With total liquid xenon mass of about 10 tonnes, LZ will be the most sensitive experiment for WIMPs in this mass region by the end of the decade. This report describes in detail the design of the LZ technical systems. Expected backgrounds are quantified and the performance of the experiment is presented. The LZ detector will be located at the Sanford Underground Research Facility in South Dakota. The organization of the LZ Project and a summary of the expected cost and current schedule are given., Comment: 278 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Number One (CD-1) management process. Report also available by chapter at http://hep.ucsb.edu/LZ/CDR. This version includes corrections of minor typographic errors
Published: 2015

9. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F.-T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D.-M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O’Dell, J., Oh, H., O’Neill, F. G., O’Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va’vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W.-Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., and Zarzhitsky, P.
Published: 2022
Full Text: View/download PDF

10. The LUX-ZEPLIN (LZ) experiment

Author: Akerib, D.S., Akerlof, C.W., Akimov, D.Yu., Alquahtani, A., Alsum, S.K., Anderson, T.J., Angelides, N., Araújo, H.M., Arbuckle, A., Armstrong, J.E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A.J., Balajthy, J., Balashov, S., Bang, J., Barry, M.J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E.P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T.P., Birrittella, B., Boast, K.E., Bolozdynya, A.I., Boulton, E.M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J.H., Bugaev, V.V., Bunker, R., Burdin, S., Busenitz, J.K., Campbell, J.S., Carels, C., Carlsmith, D.L., Carlson, B., Carmona-Benitez, M.C., Cascella, M., Chan, C., Cherwinka, J.J., Chiller, A.A., Chiller, C., Chott, N.I., Cole, A., Coleman, J., Colling, D., Conley, R.A., Cottle, A., Coughlen, R., Craddock, W.W., Curran, D., Currie, A., Cutter, J.E., da Cunha, J.P., Dahl, C.E., Dardin, S., Dasu, S., Davis, J., Davison, T.J.R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J.E.Y., Druszkiewicz, E., Dushkin, A., Edberg, T.K., Edwards, W.R., Edwards, B.N., Edwards, J., Elnimr, M.M., Emmet, W.T., Eriksen, S.R., Faham, C.H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Fogarty Florang, I.M., Ford, P., Francis, V.B., Froborg, F., Fruth, T., Gaitskell, R.J., Gantos, N.J., Garcia, D., Geffre, A., Gehman, V.M., Gelfand, R., Genovesi, J., Gerhard, R.M., Ghag, C., Gibson, E., Gilchriese, M.G.D., Gokhale, S., Gomber, B., Gonda, T.G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M.G.D., Gwilliam, C.B., Hall, C.R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S.J., Hemer, D., Hertel, S.A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M.D., Holbrook, B., Holtom, E., Hor, J.Y-K., Horn, M., Huang, D.Q., Hurteau, T.W., Ignarra, C.M., Irving, M.N., Jacobsen, R.G., Jahangir, O., Jeffery, S.N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W.G., Kaboth, A.C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A.V., Khurana, I., Kim, Y.D., Kim, W.T., Kocher, C.D., Konovalov, A.M., Korley, L., Korolkova, E.V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S.W., Krebs, H.J., Kreczko, L., Krikler, B., Kudryavtsev, V.A., Kumpan, A.V., Kyre, S., Lambert, A.R., Landerud, B., Larsen, N.A., Laundrie, A., Leason, E.A., Lee, H.S., Lee, J., Lee, C., Lenardo, B.G., Leonard, D.S., Leonard, R., Lesko, K.T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F.-T., Lin, J., Lindote, A., Linehan, R., Lippincott, W.H., Liu, R., Liu, X., Loniewski, C., Lopes, M.I., López Paredes, B., Lorenzon, W., Lucero, D., Luitz, S., Lyle, J.M., Lynch, C., Majewski, P.A., Makkinje, J., Malling, D.C., Manalaysay, A., Manenti, L., Mannino, R.L., Marangou, N., Markley, D.J., MarrLaundrie, P., Martin, T.J., Marzioni, M.F., Maupin, C., McConnell, C.T., McKinsey, D.N., McLaughlin, J., Mei, D.-M., Meng, Y., Miller, E.H., Minaker, Z.J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M.E., Morad, J.A., Morrison, E., Mount, B.J., Murphy, A.St.J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H.N., Nesbit, J., Neves, F., Nikkel, J.A., Nikoleyczik, J.A., Nilima, A., O’Dell, J., Oh, H., O’Neill, F.G., O’Sullivan, K., Olcina, I., Olevitch, M.A., Oliver-Mallory, K.C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K.J., Palmaccio, V.M., Palmer, J., Pangilinan, M., Patton, S.J., Pease, E.K., Penning, B.P., Pereira, G., Pereira, C., Peterson, I.B., Piepke, A., Pierson, S., Powell, S., Preece, R.M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B.N., Reichenbacher, J., Reichhart, L., Rhyne, C.A., Richards, A., Riffard, Q., Rischbieter, G.R.C., Rodrigues, J.P., Rose, H.J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J.S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A.B.M.R., Schnee, R.W., Schubnell, M., Scovell, P.R., Severson, M., Seymour, D., Shaw, S., Shutt, G.W., Shutt, T.A., Silk, J.J., Silva, C., Skarpaas, K., Skulski, W., Smith, A.R., Smith, R.J., Smith, R.E., So, J., Solmaz, M., Solovov, V.N., Sorensen, P., Sosnovtsev, V.V., Stancu, I., Stark, M.R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T.M., Stifter, K., Studley, R., Sumner, T.J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W.C., Taylor, R., Taylor, D.J., Temples, D., Tennyson, B.P., Terman, P.A., Thomas, K.J., Thomson, J.A., Tiedt, D.R., Timalsina, M., To, W.H., Tomás, A., Tope, T.E., Tripathi, M., Tronstad, D.R., Tull, C.E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va’vra, J., Vacheret, A., Vaitkus, A., Verbus, J.R., Vietanen, T., Voirin, E., Vuosalo, C.O., Walcott, S., Waldron, W.L., Walker, K., Wang, J.J., Wang, R., Wang, L., Wang, Y., Watson, J.R., Migneault, J., Weatherly, S., Webb, R.C., Wei, W.-Z., While, M., White, R.G., White, J.T., White, D.T., Whitis, T.J., Wisniewski, W.J., Wilson, K., Witherell, M.S., Wolfs, F.L.H., Wolfs, J.D., Woodward, D., Worm, S.D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.
Published: 2020
Full Text: View/download PDF

11. The Large Underground Xenon (LUX) Experiment

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bolozdynya, A., Bradley, A., Byram, D., Cahn, S. B., Camp, C., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Chiller, A., Chiller, C., Clark, K., Classen, T., Coffey, T., Curioni, A., Dahl, E., Dazeley, S., de Viveiros, L., Dobi, A., Dragowsky, E., Druszkiewicz, E., Edwards, B., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Gilchriese, M., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Knoche, R., Kyre, S., Kwong, J., Lander, R., Larsen, N. A., Lee, C., Leonard, D. S., Lesko, K. T., Lindote, A., Lopes, M. I., Lyashenko, A., Malling, D. C., Mannino, R., Marquez, Z., McKinsey, D. N., Mei, D. -M., Mock, J., Moongweluwan, M., Morii, M., Nelson, H., Neves, F., Nikkel, J. A., Pangilinan, M., Parker, P. D., Pease, E. K., Pech, K., Phelps, P., Rodionov, A., Roberts, P., Shei, A., Shutt, T., Silva, C., Skulski, W., Solovov, V. N., Sofka, C. J., Sorensen, P., Spaans, J., Stiegler, T., Stolp, D., Svoboda, R., Sweany, M., Szydagis, M., Taylor, D., Thomson, J., Tripathi, M., Uvarov, S., Verbus, J. R., Walsh, N., Webb, R., White, D., White, J. T., Whitis, T. J., Wlasenko, M., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Large Underground Xenon (LUX) collaboration has designed and constructed a dual-phase xenon detector, in order to conduct a search for Weakly Interacting Massive Particles(WIMPs), a leading dark matter candidate. The goal of the LUX detector is to clearly detect (or exclude) WIMPS with a spin independent cross section per nucleon of $2\times 10^{-46}$ cm$^{2}$, equivalent to $\sim$1 event/100 kg/month in the inner 100-kg fiducial volume (FV) of the 370-kg detector. The overall background goals are set to have $<$1 background events characterized as possible WIMPs in the FV in 300 days of running. This paper describes the design and construction of the LUX detector., Comment: 50 pages, 16 figures
Published: 2012
Full Text: View/download PDF

12. The LUX Prototype Detector: Heat Exchanger Development

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernstein, A., Bolozdynya, A., Bradley, A., Cahn, S., Carr, D., Chapman, J. J., Clark, K., Classen, T., Curioni, A., Dahl, C. E., Dazeley, S., deViveiros, L., Dragowsky, M., Druszkiewicz, E., Fiorucci, S., Gaitskell, R. J., Hall, C., Faham, C., Holbrook, B., Kastens, L., Kazkaz, K., Kwong, J., Lander, R., Leonard, D., Malling, D., Mannino, R., McKinsey, D. N., Mei, D., Mock, J., Morii, M., Nikkel, J., Phelps, P., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Steigler, T., Svoboda, R., Sweany, M., Thomson, J., Tripathi, M., Walsh, N., Webb, R., White, J., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The LUX (Large Underground Xenon) detector is a two-phase xenon Time Projection Chamber (TPC) designed to search for WIMP-nucleon dark matter interactions. As with all noble element detectors, continuous purification of the detector medium is essential to produce a large ($>$1ms) electron lifetime; this is necessary for efficient measurement of the electron signal which in turn is essential for achieving robust discrimination of signal from background events. In this paper we describe the development of a novel purification system deployed in a prototype detector. The results from the operation of this prototype indicated heat exchange with an efficiency above 94% up to a flow rate of 42 slpm, allowing for an electron drift length greater than 1 meter to be achieved in approximately two days and sustained for the duration of the testing period., Comment: 12 pages, 9 figures
Published: 2012
Full Text: View/download PDF

13. An Ultra-Low Background PMT for Liquid Xenon Detectors

Author: Akerib, D. S., Bai, X., Bernard, E., Bernstein, A., Bradley, A., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Chan, Y-D., Clark, K., Coffey, T., deViveiros, L., Dragowsky, M., Druszkiewicz, E., Edwards, B., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Larsen, N., Lee, C., Lesko, K., Lindote, A., Lopes, M. I., Lyashenko, A., Malling, D. C., Mannino, R., McKinsey, D., Mei, D., Mock, J., Morii, M., Nelson, H., Neves, F., Nikkel, J. A., Pangilinan, M., Pech, K., Phelps, P., Shutt, T., Silva, C., Skulski, W., Solovov, V. N., Sorensen, P., Spaans, J., Stiegler, T., Sweany, M., Szydagis, M., Taylor, D., Thomson, J., Tripathi, M., Uvarov, S., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: Results are presented from radioactivity screening of two models of photomultiplier tubes designed for use in current and future liquid xenon experiments. The Hamamatsu 5.6 cm diameter R8778 PMT, used in the LUX dark matter experiment, has yielded a positive detection of four common radioactive isotopes: 238U, 232Th, 40K, and 60Co. Screening of LUX materials has rendered backgrounds from other detector materials subdominant to the R8778 contribution. A prototype Hamamatsu 7.6 cm diameter R11410 MOD PMT has also been screened, with benchmark isotope counts measured at <0.4 238U / <0.3 232Th / <8.3 40K / 2.0+-0.2 60Co mBq/PMT. This represents a large reduction, equal to a change of \times 1/24 238U / \times 1/9 232Th / \times 1/8 40K per PMT, between R8778 and R11410 MOD, concurrent with a doubling of the photocathode surface area (4.5 cm to 6.4 cm diameter). 60Co measurements are comparable between the PMTs, but can be significantly reduced in future R11410 MOD units through further material selection. Assuming PMT activity equal to the measured 90% upper limits, Monte Carlo estimates indicate that replacement of R8778 PMTs with R11410 MOD PMTs will change LUX PMT electron recoil background contributions by a factor of \times1/25 after further material selection for 60Co reduction, and nuclear recoil backgrounds by a factor of \times 1/36. The strong reduction in backgrounds below the measured R8778 levels makes the R11410 MOD a very competitive technology for use in large-scale liquid xenon detectors., Comment: v2 updated to include content after reviewer comments (Sep 2012)
Published: 2012
Full Text: View/download PDF

14. Radio-assay of Titanium samples for the LUX Experiment

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bradley, A., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Chan, Y-D., Clark, K., Classen, T., Coffey, T., Dazeley, S., deViveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Leonard, D., Lesko, K., Lyashenko, A., Malling, D. C., Mannino, R., McKinsey, D., Mei, D., Mock, J., Morii, M., Nelson, H., Nikkel, J. A., Pangilinan, M., Parker, P. D., Phelps, P., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Smith, A., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., Uvarov, S., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: We report on the screening of samples of titanium metal for their radio-purity. The screening process described in this work led to the selection of materials used in the construction of the cryostats for the Large Underground Xenon (LUX) dark matter experiment. Our measurements establish titanium as a highly desirable material for low background experiments searching for rare events. The sample with the lowest total long-lived activity was measured to contain <0.25 mBq/kg of U-238, <0.2 mBq/kg of Th-232, and <1.2 mBq/kg of K-40. Measurements of several samples also indicated the presence of short-lived (84 day half life) Sc-46, likely produced cosmogenically via muon initiated (n,p) reactions., Comment: The LUX Collaboration
Published: 2011

15. LUXSim: A Component-Centric Approach to Low-Background Simulations

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bradley, A., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Clark, K., Classen, T., Coffey, T., Dazeley, S., de Viveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Leonard, D., Lesko, K., Lyashenko, A., Malling, D. C., Mannino, R., McKinsey, D. N., Mei, D. -M, Mock, J., Morii, M., Nelson, H., Nikkel, J. A., Pangilinan, M., Parker, P. D., Phelps, P., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Physics - Data Analysis, Statistics and Probability, High Energy Physics - Experiment, Nuclear Experiment
Abstract: Geant4 has been used throughout the nuclear and high-energy physics community to simulate energy depositions in various detectors and materials. These simulations have mostly been run with a source beam outside the detector. In the case of low-background physics, however, a primary concern is the effect on the detector from radioactivity inherent in the detector parts themselves. From this standpoint, there is no single source or beam, but rather a collection of sources with potentially complicated spatial extent. LUXSim is a simulation framework used by the LUX collaboration that takes a component-centric approach to event generation and recording. A new set of classes allows for multiple radioactive sources to be set within any number of components at run time, with the entire collection of sources handled within a single simulation run. Various levels of information can also be recorded from the individual components, with these record levels also being set at runtime. This flexibility in both source generation and information recording is possible without the need to recompile, reducing the complexity of code management and the proliferation of versions. Within the code itself, casting geometry objects within this new set of classes rather than as the default Geant4 classes automatically extends this flexibility to every individual component. No additional work is required on the part of the developer, reducing development time and increasing confidence in the results. We describe the guiding principles behind LUXSim, detail some of its unique classes and methods, and give examples of usage. * Corresponding author, kareem@llnl.gov, Comment: 45 pages, 15 figures
Published: 2011
Full Text: View/download PDF

16. Development of Readout Interconnections for the Si-W Calorimeter of SiD

Author: Woods, M., Fields, R. G., Holbrook, B., Lander, R. L., Moskaleva, A., Neher, C., Pasner, J., Tripathi, M., Brau, J. E., Frey, R. E., Strom, D., Breidenbach, M., Freytag, D., Haller, G., Herbst, R., Nelson, T., Schier, S., and Schumm, B.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The SiD collaboration is developing a Si-W sampling electromagnetic calorimeter, with anticipated application for the International Linear Collider. Assembling the modules for such a detector will involve special bonding technologies for the interconnections, especially for attaching a silicon detector wafer to a flex cable readout bus. We review the interconnect technologies involved, including oxidation removal processes, pad surface preparation, solder ball selection and placement, and bond quality assurance. Our results show that solder ball bonding is a promising technique for the Si-W ECAL, and unresolved issues are being addressed., Comment: 8 pages + title, 6 figures
Published: 2011
Full Text: View/download PDF

17. After LUX: The LZ Program

Author: Malling, D. C., Akerib, D. S., Araujo, H. M., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bradley, A., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Clark, K., Classen, T., Coffey, T., Curioni, A., Currie, A., Dazeley, S., de Viveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Leonard, D., Lesko, K., Lindote, A., Lopes, M. I., Lyashenko, A., Majewski, P., Mannino, R., McKinsey, D. N., Mei, D. -M., Mock, J., Morii, M., Murphy, A. St J., Nelson, H., Neves, F., Nikkel, J. A., Pangilinan, M., Phelps, P., Reichhart, L., Shutt, T., Silva, C., Skulski, W., Solovov, V., Sorensen, P., Spaans, J., Stiegler, T., Sumner, T. J., Svoboda, R., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The LZ program consists of two stages of direct dark matter searches using liquid Xe detectors. The first stage will be a 1.5-3 tonne detector, while the last stage will be a 20 tonne detector. Both devices will benefit tremendously from research and development performed for the LUX experiment, a 350 kg liquid Xe dark matter detector currently operating at the Sanford Underground Laboratory. In particular, the technology used for cryogenics and electrical feedthroughs, circulation and purification, low-background materials and shielding techniques, electronics, calibrations, and automated control and recovery systems are all directly scalable from LUX to the LZ detectors. Extensive searches for potential background sources have been performed, with an emphasis on previously undiscovered background sources that may have a significant impact on tonne-scale detectors. The LZ detectors will probe spin-independent interaction cross sections as low as 5E-49 cm2 for 100 GeV WIMPs, which represents the ultimate limit for dark matter detection with liquid xenon technology., Comment: Conference proceedings from APS DPF 2011. 9 pages, 6 figures
Published: 2011

18. Data Acquisition and Readout System for the LUX Dark Matter Experiment

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bradley, A., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Clark, K., Classen, T., Coffey, T., Curioni, A., Dazeley, S., deViveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Leonard, D., Lesko, K., Lyashenko, A., Malling, D. C., Mannino, R., McKinsey, D. N., Mei, D., Mock, J., Morii, M., Nelson, H., Nikkel, J. A., Pangilinan, M., Phelps, P., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., and Zhang, C.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: LUX is a two-phase (liquid/gas) xenon time projection chamber designed to detect nuclear recoils from interactions with dark matter particles. Signals from the LUX detector are processed by custom-built analog electronics which provide properly shaped signals for the trigger and data acquisition (DAQ) systems. The DAQ is comprised of commercial digitizers with firmware customized for the LUX experiment. Data acquisition systems in rare-event searches must accommodate high rate and large dynamic range during precision calibrations involving radioactive sources, while also delivering low threshold for maximum sensitivity. The LUX DAQ meets these challenges using real-time baseline sup- pression that allows for a maximum event acquisition rate in excess of 1.5 kHz with virtually no deadtime. This paper describes the LUX DAQ and the novel acquisition techniques employed in the LUX experiment.
Published: 2011
Full Text: View/download PDF

19. Status of the LUX Dark Matter Search

Author: Fiorucci, S., Akerib, D. S., Bedikian, S., Bernstein, A., Bolozdynya, A., Bradley, A., Carr, D., Chapman, J., Clark, K., Classen, T., Curioni, A., Dahl, E., Dazeley, S., de Viveiros, L., Druszkiewicz, E., Gaitskell, R., Hall, C., Faham, C. Hernandez, Holbrook, B., Kastens, L., Kazkaz, K., Lander, R., Lesko, K., Malling, D., Mannino, R., McKinsey, D., Mei, D., Mock, J., Nikkel, J., Phelps, P., Schroeder, U., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Sweany, M., Thomson, J., Toke, J., Tripathi, M., Walsh, N., Webb, R., White, J., Wolfs, F., Woods, M., and Zhang, C.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Large Underground Xenon (LUX) dark matter search experiment is currently being deployed at the Homestake Laboratory in South Dakota. We will highlight the main elements of design which make the experiment a very strong competitor in the field of direct detection, as well as an easily scalable concept. We will also present its potential reach for supersymmetric dark matter detection, within various timeframes ranging from 1 year to 5 years or more., Comment: 4 pages, in proceedings of the SUSY09 conference
Published: 2009
Full Text: View/download PDF

20. The Large Underground Xenon (LUX) experiment

Author: Akerib, DS, Bai, X, Bedikian, S, Bernard, E, Bernstein, A, Bolozdynya, A, Bradley, A, Byram, D, Cahn, SB, Camp, C, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Chiller, A, Chiller, C, Clark, K, Classen, T, Coffey, T, Curioni, A, Dahl, E, Dazeley, S, de Viveiros, L, Dobi, A, Dragowsky, E, Druszkiewicz, E, Edwards, B, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Gilchriese, M, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Knoche, R, Kyre, S, Kwong, J, Lander, R, Larsen, NA, Lee, C, Leonard, DS, Lesko, KT, Lindote, A, Lopes, MI, Lyashenko, A, Malling, DC, Mannino, R, Marquez, Z, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morii, M, Nelson, H, Neves, F, Nikkel, JA, Pangilinan, M, Parker, PD, Pease, EK, Pech, K, Phelps, P, Rodionov, A, Roberts, P, Shei, A, Shutt, T, Silva, C, Skulski, W, Solovov, VN, Sofka, CJ, Sorensen, P, Spaans, J, Stiegler, T, Stolp, D, Svoboda, R, Sweany, M, Szydagis, M, Taylor, D, Thomson, J, Tripathi, M, Uvarov, S, Verbus, JR, Walsh, N, Webb, R, White, D, White, JT, Whitis, TJ, Wlasenko, M, Wolfs, FLH, Woods, M, and Zhang, C
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Dark matter detectors, Liquid xenon, physics.ins-det, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract: The Large Underground Xenon (LUX) collaboration has designed and constructed a dual-phase xenon detector, in order to conduct a search for Weakly Interacting Massive Particles (WIMPs), a leading dark matter candidate. The goal of the LUX detector is to clearly detect (or exclude) WIMPS with a spin independent cross-section per nucleon of 2×10-46cm2, equivalent to ∼1event/100kg/month in the inner 100-kg fiducial volume (FV) of the 370-kg detector. The overall background goals are set to have
Published: 2013

21. An ultra-low background PMT for liquid xenon detectors

Author: Akerib, DS, Bai, X, Bernard, E, Bernstein, A, Bradley, A, Byram, D, Cahn, SB, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Clark, K, Coffey, T, Edwards, B, de Viveiros, L, Dragowsky, M, Druszkiewicz, E, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Larsen, N, Lee, C, Lindote, A, Lopes, MI, Lyashenko, A, Malling, DC, Mannino, R, McKinsey, DN, Mei, D-M, Mock, J, Morii, M, Nelson, H, Neves, F, Nikkel, JA, Pangilinan, M, Phelps, P, Shutt, T, Silva, C, Skulski, W, Solovov, VN, Sorensen, P, Spaans, J, Stiegler, T, Sweany, M, Szydagis, M, Taylor, D, Thomson, J, Tripathi, M, Uvarov, S, Verbus, JR, Walsh, N, Webb, R, White, JT, Wlasenko, M, Wolfs, FLH, Woods, M, and Zhang, C
Subjects: PMT, Liquid xenon detectors, Radioactivity, physics.ins-det, astro-ph.IM, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics
Abstract: Results are presented from radioactivity screening of two models of photomultiplier tubes designed for use in current and future liquid xenon experiments. The Hamamatsu 5.6 cm diameter R8778 PMT, used in the LUX dark matter experiment, has yielded a positive detection of four common radioactive isotopes: 238U, 232Th, 40K, and 60Co. Screening of LUX materials has rendered backgrounds from other detector materials subdominant to the R8778 contribution. A prototype Hamamatsu 7.6 cm diameter R11410 MOD PMT has also been screened, with benchmark isotope counts measured at
Published: 2013

22. LUXSim: A component-centric approach to low-background simulations

Author: Akerib, DS, Bai, X, Bedikian, S, Bernard, E, Bernstein, A, Bradley, A, Cahn, SB, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Clark, K, Classen, T, Coffey, T, Dazeley, S, De Viveiros, L, Dobi, A, Dragowsky, M, Druszkiewicz, E, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Lander, R, Larsen, N, Lee, C, Leonard, D, Lesko, K, Lyashenko, A, Malling, DC, Mannino, R, McKinsey, DN, Mei, DM, Mock, J, Morii, M, Nelson, H, Nikkel, JA, Pangilinan, M, Parker, PD, Phelps, P, Shutt, T, Skulski, W, Sorensen, P, Spaans, J, Stiegler, T, Svoboda, R, Sweany, M, Szydagis, M, Thomson, J, Tripathi, M, Verbus, JR, Walsh, N, Webb, R, White, JT, Wlasenko, M, Wolfs, FLH, Woods, M, and Zhang, C
Subjects: Simulation, Low-background, Dark matter, Underground, Geant4, physics.data-an, hep-ex, nucl-ex, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract: Geant4 has been used throughout the nuclear and high-energy physics community to simulate energy depositions in various detectors and materials. These simulations have mostly been run with a source beam outside the detector. In the case of low-background physics, however, a primary concern is the effect on the detector from radioactivity inherent in the detector parts themselves. From this standpoint, there is no single source or beam, but rather a collection of sources with potentially complicated spatial extent. LUXSim is a simulation framework used by the LUX collaboration that takes a component-centric approach to event generation and recording. A new set of classes allows for multiple radioactive sources to be set within any number of components at run time, with the entire collection of sources handled within a single simulation run. Various levels of information can also be recorded from the individual components, with these record levels also being set at run time. This flexibility in both source generation and information recording is possible without the need to recompile, reducing the complexity of code management and the proliferation of versions. Within the code itself, casting geometry objects within this new set of classes rather than as the default Geant4 classes automatically extends this flexibility to every individual component. No additional work is required on the part of the developer, reducing development time and increasing confidence in the results. We describe the guiding principles behind LUXSim, detail some of its unique classes and methods, and give examples of usage. © 2012 Elsevier B.V. All rights reserved.
Published: 2012

23. Data acquisition and readout system for the LUX dark matter experiment

Author: Akerib, DS, Bai, X, Bedikian, S, Bernard, E, Bernstein, A, Bradley, A, Cahn, SB, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Clark, K, Classen, T, Coffey, T, Curioni, A, Dazeley, S, De Viveiros, L, Dragowsky, M, Druszkiewicz, E, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Lander, R, Larsen, N, Lee, C, Leonard, D, Lesko, K, Lyashenko, A, Malling, DC, Mannino, R, McKinsey, DN, Mei, D, Mock, J, Morii, M, Nelson, H, Nikkel, JA, Pangilinan, M, Phelps, P, Shutt, T, Skulski, W, Sorensen, P, Spaans, J, Stiegler, T, Svoboda, R, Sweany, M, Szydagis, M, Thomson, J, Tripathi, M, Verbus, JR, Walsh, N, Webb, R, White, JT, Wlasenko, M, Wolfs, FLH, Woods, M, and Zhang, C
Subjects: Dark matter detectors, Data acquisition, Liquid xenon, astro-ph.IM, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract: LUX is a two-phase (liquid/gas) xenon time projection chamber designed to detect nuclear recoils from interactions with dark matter particles. Signals from the LUX detector are processed by custom-built analog electronics which provide properly shaped signals for the trigger and data acquisition (DAQ) systems. The DAQ is composed of commercial digitizers with firmware customized for the LUX experiment. Data acquisition systems in rare-event searches must accommodate high rate and large dynamic range during precision calibrations involving radioactive sources, while also delivering low threshold for maximum sensitivity. The LUX DAQ meets these challenges using real-time baseline suppression that allows for a maximum event acquisition rate in excess of 1.5 kHz with virtually no deadtime. This paper describes the LUX DAQ and the novel acquisition techniques employed in the LUX experiment. © 2011 Elsevier B.V. All rights reserved.
Published: 2012

24. Radio-assay of Titanium samples for the LUX Experiment

Author: Akerib, DS, Bai, X, Bedikian, S, Bernard, E, Bernstein, A, Bradley, A, Cahn, SB, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Chan, Y-D, Clark, K, Classen, T, Coffey, T, Dazeley, S, deViveiros, L, Dragowsky, M, Druszkiewicz, E, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Lander, R, Larsen, N, Lee, C, Leonard, D, Lesko, K, Lyashenko, A, Malling, DC, Mannino, R, McKinsey, D, Mei, D, Mock, J, Morii, M, Nelson, H, Nikkel, JA, Pangilinan, M, Parker, PD, Phelps, P, Shutt, T, Skulski, W, Sorensen, P, Spaans, J, Stiegler, T, Svoboda, R, Smith, A, Sweany, M, Szydagis, M, Thomson, J, Tripathi, M, Verbus, JR, Walsh, N, Webb, R, White, JT, Wlasenko, M, Wolfs, FLH, Woods, M, Uvarov, S, and Zhang, C
Subjects: physics.ins-det, hep-ex
Abstract: We report on the screening of samples of titanium metal for theirradio-purity. The screening process described in this work led to the selectionof materials used in the construction of the cryostats for the LargeUnderground Xenon (LUX) dark matter experiment. Our measurements establishtitanium as a highly desirable material for low background experimentssearching for rare events. The sample with the lowest total long-lived activitywas measured to contain
Published: 2011

25. After LUX: The LZ program

Author: Malling, DC, Chapman, JJ, Faham, CH, Fiorucci, S, Gaitskell, RJ, Pangilinan, M, Verbus, JR, Akerib, DS, Bradley, A, Carmona-Benitez, MC, Clark, K, Coffey, T, Dragowsky, M, Gibson, KR, Lee, C, Phelps, P, Shutt, T, Araújo, HM, Currie, A, Sumner, TJ, Bai, X, Hanhardt, M, Bedikian, S, Bernard, E, Cahn, SB, Kastens, L, Larsen, N, Lyashenko, A, McKinsey, DN, Nikkel, JA, Bernstein, A, Carr, D, Dazeley, S, Kazkaz, K, Sorensen, P, Classen, T, Holbrook, B, Lander, R, Mock, J, Svoboda, R, Sweany, M, Szydagis, M, Thomson, J, Tripathi, M, Walsh, N, Woods, M, de Viveiros, L, Lindote, A, Lopes, MI, Neves, F, Silva, C, Solovov, V, Druszkiewicz, E, Skulski, W, Wolfs, FLH, Hall, C, Leonard, D, Ihm, M, Jacobsen, RG, Lesko, K, Majewski, P, Mannino, R, Stiegler, T, Webb, R, White, JT, Mei, DM, Spaans, J, Zhang, C, Morii, M, Wlasenko, M, Murphy, ASJ, Reichhart, L, and Nelson, H
Subjects: astro-ph.IM, astro-ph.CO
Abstract: © Proceedings of the 2011 Meeting of the Division of Particles and Fields of the American Physical Society, DPF 2011. All rights reserved. The LZ program consists of two stages of direct dark matter searches using liquid Xe detectors. The first stage will be a 1.5-3 tonne detector, while the last stage will be a 20 tonne detector. Both devices will benefit tremendously from research and development performed for the LUX experiment, a 350 kg liquid Xe dark matter detector currently operating at the Sanford Underground Laboratory. In particular, the technology used for cryogenics and electrical feedthroughs, circulation and purification, low-background materials and shielding techniques, electronics, calibrations, and automated control and recovery systems are all directly scalable from LUX to the LZ detectors. Extensive searches for potential background sources have been performed, with an emphasis on previously undiscovered background sources that may have a significant impact on tonne-scale detectors. The LZ detectors will probe spin-independent interaction cross sections as low as 5 × 10-49 cm2 for 100 GeV WIMPs, which represents the ultimate limit for dark matter detection with liquid xenon technology.
Published: 2011

26. Status of the LUX Dark Matter Search

Author: Fiorucci, S, Akerib, DS, Bedikian, S, Bernstein, A, Bolozdynya, A, Bradley, A, Carr, D, Chapman, J, Clark, K, Classen, T, Curioni, A, Dahl, E, Dazeley, S, de Viveiros, L, Druszkiewicz, E, Gaitskell, R, Hall, C, Hernandez Faham, C, Holbrook, B, Kastens, L, Kazkaz, K, Lander, R, Lesko, K, Malling, D, Mannino, R, McKinsey, D, Mei, D, Mock, J, Nikkel, J, Phelps, P, Schroeder, U, Shutt, T, Skulski, W, Sorensen, P, Spaans, J, Stiegler, T, Svoboda, R, Sweany, M, Thomson, J, Toke, J, Tripathi, M, Walsh, N, Webb, R, White, J, Wolfs, F, Woods, M, Zhang, C, Alverson, George, Nath, Pran, and Nelson, Brent
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Dark Matter, LUX, astro-ph.CO, astro-ph.IM
Abstract: The Large Underground Xenon (LUX) dark matter search experiment is currently being deployed at the Homestake Laboratory in South Dakota. We will highlight the main elements of design which make the experiment a very strong competitor in the field of direct detection, as well as an easily scalable concept. We will also present its potential reach for supersymmetric dark matter detection, within various timeframes ranging from 1 year to 5 years or more. © 2010 American Institute of Physics.
Published: 2010

27. Status of the LUX dark matter search

Author: Fiorucci, S, Akerib, DS, Bedikian, S, Bernstein, A, Bolozdynya, A, Bradley, A, Carr, D, Chapman, J, Clark, K, Classen, T, Curioni, A, Dahl, E, Dazeley, S, De Viveiros, L, Druszkiewicz, E, Gaitskell, R, Hall, C, Hernandez Faham, C, Holbrook, B, Kastens, L, Kazkaz, K, Lander, R, Lesko, K, Malling, D, Mannino, R, McKinsey, D, Mei, D, Mock, J, Nikkel, J, Phelps, P, Schroeder, U, Shutt, T, Skulski, W, Sorensen, P, Spaans, J, Stiegler, T, Svoboda, R, Sweany, M, Thomson, J, Toke, J, Tripathi, M, Walsh, N, Webb, R, White, J, Wolfs, F, Woods, M, and Zhang, C
Subjects: Dark Matter, LUX, astro-ph.CO, astro-ph.IM
Abstract: The Large Underground Xenon (LUX) dark matter search experiment is currently being deployed at the Homestake Laboratory in South Dakota. We will highlight the main elements of design which make the experiment a very strong competitor in the field of direct detection, as well as an easily scalable concept. We will also present its potential reach for supersymmetric dark matter detection, within various timeframes ranging from 1 year to 5 years or more. © 2010 American Institute of Physics.
Published: 2009

28. Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

Author: Romiti, Giulio Francesco, Proietti, Marco, Vitolo, Marco, Bonini, Niccolò, Fawzy, Ameenathul Mazaya, Ding, Wern Yew, Fauchier, Laurent, Marin, Francisco, Nabauer, Michael, Dan, Gheorghe Andrei, Potpara, Tatjana S., Boriani, Giuseppe, Lip, Gregory Y. H., Tavazzi, L., Maggioni, A. P., Kalarus, Z., Ferrari, R., Shantsila, A., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E. N., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M. R., Crijns, H., Erküner, Atar, D., Lenarczyk, R., Oliveira, M. Martins, Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Joensen, A. Marni, Gammelmark, A., Rasmussen, L. Hvilsted, Dinesen, P., Venø, S. Krogh, Sorensen, B., Korsgaard, A., Andersen, K., Hellum, C. Fragtrup, Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Popescu, M. Ioachim, Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Polovina, M., Vujisic-Tesic, B., Nedeljkovic, M., Zlatar, M., Asanin, M., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Ortega, M. Gil, Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Kurklu, S. Tan, Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Senoo, K., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O’Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Romiti G.F., Proietti M., Vitolo M., Bonini N., Fawzy A.M., Ding W.Y., Fauchier L., Marin F., Nabauer M., Dan G.A., Potpara T.S., Boriani G., Lip G.Y.H., Tavazzi L., Maggioni A.P., Kalarus Z., Ferrari R., Shantsila A., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E.N., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M.R., Crijns H., Erkuner O., Atar D., Lenarczyk R., Oliveira M.M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., el Husseini Z., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Joensen A.M., Gammelmark A., Rasmussen L.H., Dinesen P., Veno S.K., Sorensen B., Korsgaard A., Andersen K., Hellum C.F., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V.L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Burg M., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., Van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Popescu M.I., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Polovina M., Vujisic-Tesic B., Nedeljkovic M., Zlatar M., Asanin M., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Ortega M.G., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I.E., Yilmaz K., Ozin B., Kurklu S.T., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A.K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U.O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M.B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Senoo K., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Cardiology, Pulmonary Medicine, General Practice, ACS - Heart failure & arrhythmias, Medical Oncology, Erasmus School of Health Policy & Management, Radiotherapy, Department of Technology and Operations Management, Virology, Erasmus School of Social and Behavioural Sciences, Child and Adolescent Psychiatry / Psychology, Internal Medicine, Tax Law, Epidemiology, Neurosciences, Rheumatology, Erasmus School of Economics, Department of Business-Society Management, Pediatrics, Erasmus MC other, Orthopedics and Sports Medicine, Intensive Care, Department of Marketing Management, Clinical Genetics, Surgery, Econometrics, Research & Education, Radiology & Nuclear Medicine, Neurosurgery, Psychiatry, Department of Psychology, Education and Child Studies, Plastic and Reconstructive Surgery and Hand Surgery, Dermatology, Public Health, Gastroenterology & Hepatology, Erasmus School of Law, and Sociology
Subjects: Registrie, Atrial Fibrillation/drug therapy, Integrated management, Risk Factor, Atrial fibrillation, Clinical complexity, Outcomes, Anticoagulants, Humans, Registries, Risk Factors, Atrial Fibrillation, Stroke, Anticoagulant, General Medicine, Anticoagulants/therapeutic use, Stroke/complications, Outcome, Human
Abstract: Background Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients.
Published: 2022
Full Text: View/download PDF

29. Impact of renal impairment on atrial fibrillation

Author: Ding W. Y., Potpara T. S., Blomstrom-Lundqvist C., Boriani G., Marin F., Fauchier L., Lip G. Y. H., Tavazzi L., Maggioni A. P., Dan G. -A., Potpara T., Nabauer M., Kalarus Z., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M., Crijns H., Erkuner O., Atar D., Lenarczyk R., Martins Oliveira M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., Husseini Z. E., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Marni Joensen A., Gammelmark A., Hvilsted Rasmussen L., Dinesen P., Krogh Veno S., Sorensen B., Korsgaard A., Andersen K., Fragtrup Hellum C., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V. L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Ioachim Popescu M., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Vukmirovic L., Radisavljevic M., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Radovanovic S., Kocijancic A., Obrenovic-Kircanski B., Kalimanovska Ostric D., Simic D., Jovanovic I., Petrovic I., Polovina M., Vukicevic M., Tomasevic M., Mujovic N., Radivojevic N., Petrovic O., Aleksandric S., Kovacevic V., Mijatovic Z., Ivanovic B., Tesic M., Ristic A., Vujisic-Tesic B., Nedeljkovic M., Karadzic A., Uscumlic A., Prodanovic M., Zlatar M., Asanin M., Bisenic B., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Backovic S., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Djordjevic D., Damjanovic M., Zdravkovic S., Topic V., Stanojevic D., Randjelovic M., Jankovic-Tomasevic R., Atanaskovic V., Antic S., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Mijatovic A., Tanasic D., Radakovic G., Peranovic J., Panic-Jelic N., Vujadinovic O., Pajic P., Bekic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Gil Ortega M., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I. E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A. K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U. O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M. B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Ding W.Y., Potpara T.S., Blomstrom-Lundqvist C., Boriani G., Marin F., Fauchier L., Lip G.Y.H., Tavazzi L., Maggioni A.P., Dan G.-A., Potpara T., Nabauer M., Kalarus Z., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M., Crijns H., Erkuner O., Atar D., Lenarczyk R., Martins Oliveira M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., Husseini Z.E., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Marni Joensen A., Gammelmark A., Hvilsted Rasmussen L., Dinesen P., Krogh Veno S., Sorensen B., Korsgaard A., Andersen K., Fragtrup Hellum C., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V.L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Ioachim Popescu M., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Vukmirovic L., Radisavljevic M., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Radovanovic S., Kocijancic A., Obrenovic-Kircanski B., Kalimanovska Ostric D., Simic D., Jovanovic I., Petrovic I., Polovina M., Vukicevic M., Tomasevic M., Mujovic N., Radivojevic N., Petrovic O., Aleksandric S., Kovacevic V., Mijatovic Z., Ivanovic B., Tesic M., Ristic A., Vujisic-Tesic B., Nedeljkovic M., Karadzic A., Uscumlic A., Prodanovic M., Zlatar M., Asanin M., Bisenic B., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Backovic S., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Djordjevic D., Damjanovic M., Zdravkovic S., Topic V., Stanojevic D., Randjelovic M., Jankovic-Tomasevic R., Atanaskovic V., Antic S., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Mijatovic A., Tanasic D., Radakovic G., Peranovic J., Panic-Jelic N., Vujadinovic O., Pajic P., Bekic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Gil Ortega M., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I.E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A.K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U.O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M.B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, and Radiology and nuclear medicine
Subjects: Male, Medicin och hälsovetenskap, Clinical Biochemistry, Hemorrhage, Medical and Health Sciences, Biochemistry, Brain Ischemia, Risk Factors, Hemorrhage/chemically induced, death, Humans, Acute Coronary Syndrome/complications, atrial fibrillation, Renal Insufficiency, Registries, Acute Coronary Syndrome, Renal Insufficiency/chemically induced, Anticoagulants, General Medicine, thromboembolism, kidney failure, Stroke, Anticoagulants/therapeutic use, major bleeding, outcome, Female, Atrial Fibrillation/complications, chronic kidney disease, Stroke/complications
Abstract: Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p 2 decrease), that was most notable in patients with eGFR 2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m 2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF.
Published: 2022
Full Text: View/download PDF

30. Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author: Ding, Wern Yew, primary, Kotalczyk, Agnieszka, additional, Boriani, Giuseppe, additional, Marin, Francisco, additional, Blomström-Lundqvist, Carina, additional, Potpara, Tatjana S., additional, Fauchier, Laurent, additional, Lip, Gregory.Y.H., additional, Boriani, G., additional, Lip, G.Y.H., additional, Tavazzi, L., additional, Maggioni, A.P., additional, Dan, G.-A., additional, Potpara, T., additional, Nabauer, M., additional, Marin, F., additional, Kalarus, Z., additional, Goda, A., additional, Mairesse, G., additional, Shalganov, T., additional, Antoniades, L., additional, Taborsky, M., additional, Riahi, S., additional, Muda, P., additional, García Bolao, I., additional, Piot, O., additional, Etsadashvili, K., additional, Simantirakis, E., additional, Haim, M., additional, Azhari, A., additional, Najafian, J., additional, Santini, M., additional, Mirrakhimov, E., additional, Kulzida, K.A., additional, Erglis, A., additional, Poposka, L., additional, Burg, M., additional, Crijns, H., additional, Erküner, Ö., additional, Atar, D., additional, Lenarczyk, R., additional, Martins Oliveira, M., additional, Shah, D., additional, Serdechnaya, E., additional, Diker, E., additional, Lane, D., additional, Zëra, E., additional, Ekmekçiu, U., additional, Paparisto, V., additional, Tase, M., additional, Gjergo, H., additional, Dragoti, J., additional, Ciutea, M., additional, Ahadi, N., additional, el Husseini, Z., additional, Raepers, M., additional, Leroy, J., additional, Haushan, P., additional, Jourdan, A., additional, Lepiece, C., additional, Desteghe, L., additional, Vijgen, J., additional, Koopman, P., additional, Van Genechten, G., additional, Heidbuchel, H., additional, Boussy, T., additional, De Coninck, M., additional, Van Eeckhoutte, H., additional, Bouckaert, N., additional, Friart, A., additional, Boreux, J., additional, Arend, C., additional, Evrard, P., additional, Stefan, L., additional, Hoffer, E., additional, Herzet, J., additional, Massoz, M., additional, Celentano, C., additional, Sprynger, M., additional, Pierard, L., additional, Melon, P., additional, Van Hauwaert, B., additional, Kuppens, C., additional, Faes, D., additional, Van Lier, D., additional, Van Dorpe, A., additional, Gerardy, A., additional, Deceuninck, O., additional, Xhaet, O., additional, Dormal, F., additional, Ballant, E., additional, Blommaert, D., additional, Yakova, D., additional, Hristov, M., additional, Yncheva, T., additional, Stancheva, N., additional, Tisheva, S., additional, Tokmakova, M., additional, Nikolov, F., additional, Gencheva, D., additional, Kunev, B., additional, Stoyanov, M., additional, Marchov, D., additional, Gelev, V., additional, Traykov, V., additional, Kisheva, A., additional, Tsvyatkov, H., additional, Shtereva, R., additional, Bakalska-Georgieva, S., additional, Slavcheva, S., additional, Yotov, Y., additional, Kubíčková, M., additional, Marni Joensen, A., additional, Gammelmark, A., additional, Hvilsted Rasmussen, L., additional, Dinesen, P., additional, Krogh Venø, S., additional, Sorensen, B., additional, Korsgaard, A., additional, Andersen, K., additional, Fragtrup Hellum, C., additional, Svenningsen, A., additional, Nyvad, O., additional, Wiggers, P., additional, May, O., additional, Aarup, A., additional, Graversen, B., additional, Jensen, L., additional, Andersen, M., additional, Svejgaard, M., additional, Vester, S., additional, Hansen, S., additional, Lynggaard, V., additional, Ciudad, M., additional, Vettus, R., additional, Maestre, A., additional, Castaño, S., additional, Cheggour, S., additional, Poulard, J., additional, Mouquet, V., additional, Leparrée, S., additional, Bouet, J., additional, Taieb, J., additional, Doucy, A., additional, Duquenne, H., additional, Furber, A., additional, Dupuis, J., additional, Rautureau, J., additional, Font, M., additional, Damiano, P., additional, Lacrimini, M., additional, Abalea, J., additional, Boismal, S., additional, Menez, T., additional, Mansourati, J., additional, Range, G., additional, Gorka, H., additional, Laure, C., additional, Vassalière, C., additional, Elbaz, N., additional, Lellouche, N., additional, Djouadi, K., additional, Roubille, F., additional, Dietz, D., additional, Davy, J., additional, Granier, M., additional, Winum, P., additional, Leperchois-Jacquey, C., additional, Kassim, H., additional, Marijon, E., additional, Le Heuzey, J., additional, Fedida, J., additional, Maupain, C., additional, Himbert, C., additional, Gandjbakhch, E., additional, Hidden-Lucet, F., additional, Duthoit, G., additional, Badenco, N., additional, Chastre, T., additional, Waintraub, X., additional, Oudihat, M., additional, Lacoste, J., additional, Stephan, C., additional, Bader, H., additional, Delarche, N., additional, Giry, L., additional, Arnaud, D., additional, Lopez, C., additional, Boury, F., additional, Brunello, I., additional, Lefèvre, M., additional, Mingam, R., additional, Haissaguerre, M., additional, Le Bidan, M., additional, Pavin, D., additional, Le Moal, V., additional, Leclercq, C., additional, Beitar, T., additional, Martel, I., additional, Schmid, A., additional, Sadki, N., additional, Romeyer-Bouchard, C., additional, Da Costa, A., additional, Arnault, I., additional, Boyer, M., additional, Piat, C., additional, Lozance, N., additional, Nastevska, S., additional, Doneva, A., additional, Fortomaroska Milevska, B., additional, Sheshoski, B., additional, Petroska, K., additional, Taneska, N., additional, Bakrecheski, N., additional, Lazarovska, K., additional, Jovevska, S., additional, Ristovski, V., additional, Antovski, A., additional, Lazarova, E., additional, Kotlar, I., additional, Taleski, J., additional, Kedev, S., additional, Zlatanovik, N., additional, Jordanova, S., additional, Bajraktarova Proseva, T., additional, Doncovska, S., additional, Maisuradze, D., additional, Esakia, A., additional, Sagirashvili, E., additional, Lartsuliani, K., additional, Natelashvili, N., additional, Gumberidze, N., additional, Gvenetadze, R., additional, Gotonelia, N., additional, Kuridze, N., additional, Papiashvili, G., additional, Menabde, I., additional, Glöggler, S., additional, Napp, A., additional, Lebherz, C., additional, Romero, H., additional, Schmitz, K., additional, Berger, M., additional, Zink, M., additional, Köster, S., additional, Sachse, J., additional, Vonderhagen, E., additional, Soiron, G., additional, Mischke, K., additional, Reith, R., additional, Schneider, M., additional, Rieker, W., additional, Boscher, D., additional, Taschareck, A., additional, Beer, A., additional, Oster, D., additional, Ritter, O., additional, Adamczewski, J., additional, Walter, S., additional, Frommhold, A., additional, Luckner, E., additional, Richter, J., additional, Schellner, M., additional, Landgraf, S., additional, Bartholome, S., additional, Naumann, R., additional, Schoeler, J., additional, Westermeier, D., additional, William, F., additional, Wilhelm, K., additional, Maerkl, M., additional, Oekinghaus, R., additional, Denart, M., additional, Kriete, M., additional, Tebbe, U., additional, Scheibner, T., additional, Gruber, M., additional, Gerlach, A., additional, Beckendorf, C., additional, Anneken, L., additional, Arnold, M., additional, Lengerer, S., additional, Bal, Z., additional, Uecker, C., additional, Förtsch, H., additional, Fechner, S., additional, Mages, V., additional, Martens, E., additional, Methe, H., additional, Schmidt, T., additional, Schaeffer, B., additional, Hoffmann, B., additional, Moser, J., additional, Heitmann, K., additional, Willems, S., additional, Klaus, C., additional, Lange, I., additional, Durak, M., additional, Esen, E., additional, Mibach, F., additional, Mibach, H., additional, Utech, A., additional, Gabelmann, M., additional, Stumm, R., additional, Ländle, V., additional, Gartner, C., additional, Goerg, C., additional, Kaul, N., additional, Messer, S., additional, Burkhardt, D., additional, Sander, C., additional, Orthen, R., additional, Kaes, S., additional, Baumer, A., additional, Dodos, F., additional, Barth, A., additional, Schaeffer, G., additional, Gaertner, J., additional, Winkler, J., additional, Fahrig, A., additional, Aring, J., additional, Wenzel, I., additional, Steiner, S., additional, Kliesch, A., additional, Kratz, E., additional, Winter, K., additional, Schneider, P., additional, Haag, A., additional, Mutscher, I., additional, Bosch, R., additional, Taggeselle, J., additional, Meixner, S., additional, Schnabel, A., additional, Shamalla, A., additional, Hötz, H., additional, Korinth, A., additional, Rheinert, C., additional, Mehltretter, G., additional, Schön, B., additional, Schön, N., additional, Starflinger, A., additional, Englmann, E., additional, Baytok, G., additional, Laschinger, T., additional, Ritscher, G., additional, Gerth, A., additional, Dechering, D., additional, Eckardt, L., additional, Kuhlmann, M., additional, Proskynitopoulos, N., additional, Brunn, J., additional, Foth, K., additional, Axthelm, C., additional, Hohensee, H., additional, Eberhard, K., additional, Turbanisch, S., additional, Hassler, N., additional, Koestler, A., additional, Stenzel, G., additional, Kschiwan, D., additional, Schwefer, M., additional, Neiner, S., additional, Hettwer, S., additional, Haeussler-Schuchardt, M., additional, Degenhardt, R., additional, Sennhenn, S., additional, Brendel, M., additional, Stoehr, A., additional, Widjaja, W., additional, Loehndorf, S., additional, Logemann, A., additional, Hoskamp, J., additional, Grundt, J., additional, Block, M., additional, Ulrych, R., additional, Reithmeier, A., additional, Panagopoulos, V., additional, Martignani, C., additional, Bernucci, D., additional, Fantecchi, E., additional, Diemberger, I., additional, Ziacchi, M., additional, Biffi, M., additional, Cimaglia, P., additional, Frisoni, J., additional, Giannini, I., additional, Boni, S., additional, Fumagalli, S., additional, Pupo, S., additional, Di Chiara, A., additional, Mirone, P., additional, Pesce, F., additional, Zoccali, C., additional, Malavasi, V.L., additional, Mussagaliyeva, A., additional, Ahyt, B., additional, Salihova, Z., additional, Koshum-Bayeva, K., additional, Kerimkulova, A., additional, Bairamukova, A., additional, Lurina, B., additional, Zuzans, R., additional, Jegere, S., additional, Mintale, I., additional, Kupics, K., additional, Jubele, K., additional, Kalejs, O., additional, Vanhear, K., additional, Cachia, M., additional, Abela, E., additional, Warwicker, S., additional, Tabone, T., additional, Xuereb, R., additional, Asanovic, D., additional, Drakalovic, D., additional, Vukmirovic, M., additional, Pavlovic, N., additional, Music, L., additional, Bulatovic, N., additional, Boskovic, A., additional, Uiterwaal, H., additional, Bijsterveld, N., additional, De Groot, J., additional, Neefs, J., additional, van den Berg, N., additional, Piersma, F., additional, Wilde, A., additional, Hagens, V., additional, Van Es, J., additional, Van Opstal, J., additional, Van Rennes, B., additional, Verheij, H., additional, Breukers, W., additional, Tjeerdsma, G., additional, Nijmeijer, R., additional, Wegink, D., additional, Binnema, R., additional, Said, S., additional, Philippens, S., additional, van Doorn, W., additional, Szili-Torok, T., additional, Bhagwandien, R., additional, Janse, P., additional, Muskens, A., additional, van Eck, M., additional, Gevers, R., additional, van der Ven, N., additional, Duygun, A., additional, Rahel, B., additional, Meeder, J., additional, Vold, A., additional, Holst Hansen, C., additional, Engset, I., additional, Dyduch-Fejklowicz, B., additional, Koba, E., additional, Cichocka, M., additional, Sokal, A., additional, Kubicius, A., additional, Pruchniewicz, E., additional, Kowalik-Sztylc, A., additional, Czapla, W., additional, Mróz, I., additional, Kozlowski, M., additional, Pawlowski, T., additional, Tendera, M., additional, Winiarska-Filipek, A., additional, Fidyk, A., additional, Slowikowski, A., additional, Haberka, M., additional, Lachor-Broda, M., additional, Biedron, M., additional, Gasior, Z., additional, Kołodziej, M., additional, Janion, M., additional, Gorczyca-Michta, I., additional, Wozakowska-Kaplon, B., additional, Stasiak, M., additional, Jakubowski, P., additional, Ciurus, T., additional, Drozdz, J., additional, Simiera, M., additional, Zajac, P., additional, Wcislo, T., additional, Zycinski, P., additional, Kasprzak, J., additional, Olejnik, A., additional, Harc-Dyl, E., additional, Miarka, J., additional, Pasieka, M., additional, Ziemińska-Łuć, M., additional, Bujak, W., additional, Śliwiński, A., additional, Grech, A., additional, Morka, J., additional, Petrykowska, K., additional, Prasał, M., additional, Hordyński, G., additional, Feusette, P., additional, Lipski, P., additional, Wester, A., additional, Streb, W., additional, Romanek, J., additional, Woźniak, P., additional, Chlebuś, M., additional, Szafarz, P., additional, Stanik, W., additional, Zakrzewski, M., additional, Kaźmierczak, J., additional, Przybylska, A., additional, Skorek, E., additional, Błaszczyk, H., additional, Stępień, M., additional, Szabowski, S., additional, Krysiak, W., additional, Szymańska, M., additional, Karasiński, J., additional, Blicharz, J., additional, Skura, M., additional, Hałas, K., additional, Michalczyk, L., additional, Orski, Z., additional, Krzyżanowski, K., additional, Skrobowski, A., additional, Zieliński, L., additional, Tomaszewska-Kiecana, M., additional, Dłużniewski, M., additional, Kiliszek, M., additional, Peller, M., additional, Budnik, M., additional, Balsam, P., additional, Opolski, G., additional, Tymińska, A., additional, Ozierański, K., additional, Wancerz, A., additional, Borowiec, A., additional, Majos, E., additional, Dabrowski, R., additional, Szwed, H., additional, Musialik-Lydka, A., additional, Leopold-Jadczyk, A., additional, Jedrzejczyk-Patej, E., additional, Koziel, M., additional, Mazurek, M., additional, Krzemien-Wolska, K., additional, Starosta, P., additional, Nowalany-Kozielska, E., additional, Orzechowska, A., additional, Szpot, M., additional, Staszel, M., additional, Almeida, S., additional, Pereira, H., additional, Brandão Alves, L., additional, Miranda, R., additional, Ribeiro, L., additional, Costa, F., additional, Morgado, F., additional, Carmo, P., additional, Galvao Santos, P., additional, Bernardo, R., additional, Adragão, P., additional, Ferreira da Silva, G., additional, Peres, M., additional, Alves, M., additional, Leal, M., additional, Cordeiro, A., additional, Magalhães, P., additional, Fontes, P., additional, Leão, S., additional, Delgado, A., additional, Costa, A., additional, Marmelo, B., additional, Rodrigues, B., additional, Moreira, D., additional, Santos, J., additional, Santos, L., additional, Terchet, A., additional, Darabantiu, D., additional, Mercea, S., additional, Turcin Halka, V., additional, Pop Moldovan, A., additional, Gabor, A., additional, Doka, B., additional, Catanescu, G., additional, Rus, H., additional, Oboroceanu, L., additional, Bobescu, E., additional, Popescu, R., additional, Dan, A., additional, Buzea, A., additional, Daha, I., additional, Dan, G., additional, Neuhoff, I., additional, Baluta, M., additional, Ploesteanu, R., additional, Dumitrache, N., additional, Vintila, M., additional, Daraban, A., additional, Japie, C., additional, Badila, E., additional, Tewelde, H., additional, Hostiuc, M., additional, Frunza, S., additional, Tintea, E., additional, Bartos, D., additional, Ciobanu, A., additional, Popescu, I., additional, Toma, N., additional, Gherghinescu, C., additional, Cretu, D., additional, Patrascu, N., additional, Stoicescu, C., additional, Udroiu, C., additional, Bicescu, G., additional, Vintila, V., additional, Vinereanu, D., additional, Cinteza, M., additional, Rimbas, R., additional, Grecu, M., additional, Cozma, A., additional, Boros, F., additional, Ille, M., additional, Tica, O., additional, Tor, R., additional, Corina, A., additional, Jeewooth, A., additional, Maria, B., additional, Georgiana, C., additional, Natalia, C., additional, Alin, D., additional, Dinu-Andrei, D., additional, Livia, M., additional, Daniela, R., additional, Larisa, R., additional, Umaar, S., additional, Tamara, T., additional, Ioachim Popescu, M., additional, Nistor, D., additional, Sus, I., additional, Coborosanu, O., additional, Alina-Ramona, N., additional, Dan, R., additional, Petrescu, L., additional, Ionescu, G., additional, Vacarescu, C., additional, Goanta, E., additional, Mangea, M., additional, Ionac, A., additional, Mornos, C., additional, Cozma, D., additional, Pescariu, S., additional, Solodovnicova, E., additional, Soldatova, I., additional, Shutova, J., additional, Tjuleneva, L., additional, Zubova, T., additional, Uskov, V., additional, Obukhov, D., additional, Rusanova, G., additional, Isakova, N., additional, Odinsova, S., additional, Arhipova, T., additional, Kazakevich, E., additional, Zavyalova, O., additional, Novikova, T., additional, Riabaia, I., additional, Zhigalov, S., additional, Drozdova, E., additional, Luchkina, I., additional, Monogarova, Y., additional, Hegya, D., additional, Rodionova, L., additional, Nevzorova, V., additional, Lusanova, O., additional, Arandjelovic, A., additional, Toncev, D., additional, Vukmirovic, L., additional, Radisavljevic, M., additional, Milanov, M., additional, Sekularac, N., additional, Zdravkovic, M., additional, Hinic, S., additional, Dimkovic, S., additional, Acimovic, T., additional, Saric, J., additional, Radovanovic, S., additional, Kocijancic, A., additional, Obrenovic-Kircanski, B., additional, Kalimanovska Ostric, D., additional, Simic, D., additional, Jovanovic, I., additional, Petrovic, I., additional, Polovina, M., additional, Vukicevic, M., additional, Tomasevic, M., additional, Mujovic, N., additional, Radivojevic, N., additional, Petrovic, O., additional, Aleksandric, S., additional, Kovacevic, V., additional, Mijatovic, Z., additional, Ivanovic, B., additional, Tesic, M., additional, Ristic, A., additional, Vujisic-Tesic, B., additional, Nedeljkovic, M., additional, Karadzic, A., additional, Uscumlic, A., additional, Prodanovic, M., additional, Zlatar, M., additional, Asanin, M., additional, Bisenic, B., additional, Vasic, V., additional, Popovic, Z., additional, Djikic, D., additional, Sipic, M., additional, Peric, V., additional, Dejanovic, B., additional, Milosevic, N., additional, Backovic, S., additional, Stevanovic, A., additional, Andric, A., additional, Pencic, B., additional, Pavlovic-Kleut, M., additional, Celic, V., additional, Pavlovic, M., additional, Petrovic, M., additional, Vuleta, M., additional, Petrovic, N., additional, Simovic, S., additional, Savovic, Z., additional, Milanov, S., additional, Davidovic, G., additional, Iric-Cupic, V., additional, Djordjevic, D., additional, Damjanovic, M., additional, Zdravkovic, S., additional, Topic, V., additional, Stanojevic, D., additional, Randjelovic, M., additional, Jankovic-Tomasevic, R., additional, Atanaskovic, V., additional, Antic, S., additional, Simonovic, D., additional, Stojanovic, M., additional, Stojanovic, S., additional, Mitic, V., additional, Ilic, V., additional, Petrovic, D., additional, Deljanin Ilic, M., additional, Ilic, S., additional, Stoickov, V., additional, Markovic, S., additional, Mijatovic, A., additional, Tanasic, D., additional, Radakovic, G., additional, Peranovic, J., additional, Panic-Jelic, N., additional, Vujadinovic, O., additional, Pajic, P., additional, Bekic, S., additional, Kovacevic, S., additional, García Fernandez, A., additional, Perez Cabeza, A., additional, Anguita, M., additional, Tercedor Sanchez, L., additional, Mau, E., additional, Loayssa, J., additional, Ayarra, M., additional, Carpintero, M., additional, Roldán Rabadan, I., additional, Gil Ortega, M., additional, Tello Montoliu, A., additional, Orenes Piñero, E., additional, Manzano Fernández, S., additional, Marín, F., additional, Romero Aniorte, A., additional, Veliz Martínez, A., additional, Quintana Giner, M., additional, Ballesteros, G., additional, Palacio, M., additional, Alcalde, O., additional, García-Bolao, I., additional, Bertomeu Gonzalez, V., additional, Otero-Raviña, F., additional, García Seara, J., additional, Gonzalez Juanatey, J., additional, Dayal, N., additional, Maziarski, P., additional, Gentil-Baron, P., additional, Koç, M., additional, Onrat, E., additional, Dural, I.E., additional, Yilmaz, K., additional, Özin, B., additional, Tan Kurklu, S., additional, Atmaca, Y., additional, Canpolat, U., additional, Tokgozoglu, L., additional, Dolu, A.K., additional, Demirtas, B., additional, Sahin, D., additional, Ozcan Celebi, O., additional, Gagirci, G., additional, Turk, U.O., additional, Ari, H., additional, Polat, N., additional, Toprak, N., additional, Sucu, M., additional, Akin Serdar, O., additional, Taha Alper, A., additional, Kepez, A., additional, Yuksel, Y., additional, Uzunselvi, A., additional, Yuksel, S., additional, Sahin, M., additional, Kayapinar, O., additional, Ozcan, T., additional, Kaya, H., additional, Yilmaz, M.B., additional, Kutlu, M., additional, Demir, M., additional, Gibbs, C., additional, Kaminskiene, S., additional, Bryce, M., additional, Skinner, A., additional, Belcher, G., additional, Hunt, J., additional, Stancombe, L., additional, Holbrook, B., additional, Peters, C., additional, Tettersell, S., additional, Shantsila, A., additional, Senoo, K., additional, Proietti, M., additional, Russell, K., additional, Domingos, P., additional, Hussain, S., additional, Partridge, J., additional, Haynes, R., additional, Bahadur, S., additional, Brown, R., additional, McMahon, S., additional, McDonald, J., additional, Balachandran, K., additional, Singh, R., additional, Garg, S., additional, Desai, H., additional, Davies, K., additional, Goddard, W., additional, Galasko, G., additional, Rahman, I., additional, Chua, Y., additional, Payne, O., additional, Preston, S., additional, Brennan, O., additional, Pedley, L., additional, Whiteside, C., additional, Dickinson, C., additional, Brown, J., additional, Jones, K., additional, Benham, L., additional, Brady, R., additional, Buchanan, L., additional, Ashton, A., additional, Crowther, H., additional, Fairlamb, H., additional, Thornthwaite, S., additional, Relph, C., additional, McSkeane, A., additional, Poultney, U., additional, Kelsall, N., additional, Rice, P., additional, Wilson, T., additional, Wrigley, M., additional, Kaba, R., additional, Patel, T., additional, Young, E., additional, Law, J., additional, Runnett, C., additional, Thomas, H., additional, McKie, H., additional, Fuller, J., additional, Pick, S., additional, Sharp, A., additional, Hunt, A., additional, Thorpe, K., additional, Hardman, C., additional, Cusack, E., additional, Adams, L., additional, Hough, M., additional, Keenan, S., additional, Bowring, A., additional, Watts, J., additional, Zaman, J., additional, Goffin, K., additional, Nutt, H., additional, Beerachee, Y., additional, Featherstone, J., additional, Mills, C., additional, Pearson, J., additional, Stephenson, L., additional, Grant, S., additional, Wilson, A., additional, Hawksworth, C., additional, Alam, I., additional, Robinson, M., additional, Ryan, S., additional, Egdell, R., additional, Gibson, E., additional, Holland, M., additional, Leonard, D., additional, Mishra, B., additional, Ahmad, S., additional, Randall, H., additional, Hill, J., additional, Reid, L., additional, George, M., additional, McKinley, S., additional, Brockway, L., additional, Milligan, W., additional, Sobolewska, J., additional, Muir, J., additional, Tuckis, L., additional, Winstanley, L., additional, Jacob, P., additional, Kaye, S., additional, Morby, L., additional, Jan, A., additional, Sewell, T., additional, Boos, C., additional, Wadams, B., additional, Cope, C., additional, Jefferey, P., additional, Andrews, N., additional, Getty, A., additional, Suttling, A., additional, Turner, C., additional, Hudson, K., additional, Austin, R., additional, Howe, S., additional, Iqbal, R., additional, Gandhi, N., additional, Brophy, K., additional, Mirza, P., additional, Willard, E., additional, Collins, S., additional, Ndlovu, N., additional, Subkovas, E., additional, Karthikeyan, V., additional, Waggett, L., additional, Wood, A., additional, Bolger, A., additional, Stockport, J., additional, Evans, L., additional, Harman, E., additional, Starling, J., additional, Williams, L., additional, Saul, V., additional, Sinha, M., additional, Bell, L., additional, Tudgay, S., additional, Kemp, S., additional, Frost, L., additional, Ingram, T., additional, Loughlin, A., additional, Adams, C., additional, Adams, M., additional, Hurford, F., additional, Owen, C., additional, Miller, C., additional, Donaldson, D., additional, Tivenan, H., additional, Button, H., additional, Nasser, A., additional, Jhagra, O., additional, Stidolph, B., additional, Brown, C., additional, Livingstone, C., additional, Duffy, M., additional, Madgwick, P., additional, Roberts, P., additional, Greenwood, E., additional, Fletcher, L., additional, Beveridge, M., additional, Earles, S., additional, McKenzie, D., additional, Beacock, D., additional, Dayer, M., additional, Seddon, M., additional, Greenwell, D., additional, Luxton, F., additional, Venn, F., additional, Mills, H., additional, Rewbury, J., additional, James, K., additional, Roberts, K., additional, Tonks, L., additional, Felmeden, D., additional, Taggu, W., additional, Summerhayes, A., additional, Hughes, D., additional, Sutton, J., additional, Felmeden, L., additional, Khan, M., additional, Walker, E., additional, Norris, L., additional, O'Donohoe, L., additional, Mozid, A., additional, Dymond, H., additional, Lloyd-Jones, H., additional, Saunders, G., additional, Simmons, D., additional, Coles, D., additional, Cotterill, D., additional, Beech, S., additional, Kidd, S., additional, Wrigley, B., additional, Petkar, S., additional, Smallwood, A., additional, Jones, R., additional, Radford, E., additional, Milgate, S., additional, Metherell, S., additional, Cottam, V., additional, Buckley, C., additional, Broadley, A., additional, Wood, D., additional, Allison, J., additional, Rennie, K., additional, Balian, L., additional, Howard, L., additional, Pippard, L., additional, Board, S., additional, and Pitt-Kerby, T., additional
Published: 2022
Full Text: View/download PDF

31. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R., Paraboschi E. M., Gerussi A., Cordell H. J., Mells G. F., Sandford R. N., Jones D. E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K. A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S. E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P. L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G. A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P. M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L. S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C. L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S. D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V. S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S. -A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H. -J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S. -S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M. E., Seldin M. F., and Invernizzi P.
Abstract: Background & Aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10–4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10–6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028–1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09–1.26; P = 9.93 × 10–8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10–9; OR, 1.33; 95% CI, 1.21–1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

32. Epidemiology and impact of frailty in patients with atrial fibrillation in Europe

Author: Proietti, Marco, Romiti, Giulio Francesco, Vitolo, Marco, Harrison, Stephanie L., Lane, Deirdre A., Fauchier, Laurent, Marin, Francisco, Näbauer, Michael, Potpara, Tatjana S., Dan, Gheorghe-Andrei, Maggioni, Aldo P., Cesari, Matteo, Boriani, Giuseppe, Lip, Gregory Y. H., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Goda, A., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Shalganov, T., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Riahi, S., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Muda, P., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Piot, O., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Fauchier, L., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Poposka, L., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Etsadashvili, K., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Boriani, G., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Mirrakhimov, E., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Erglis, A., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Erküner, Philippens, S., van Doorn, W., Crijns, H., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Atar, D., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Zieminska-Łuć, M., Bujak, W., Sliwinski, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordynski, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Wozniak, P., Chlebus, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kazmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stepien, M., Szabowski, S., Krysiak, W., Szymanska, M., Karasinski, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyzanowski, K., Skrobowski, A., Zielinski, L., Tomaszewska-Kiecana, M., Dłuzniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tyminska, A., Ozieranski, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Lenarczyk, R., Mazurek, M., Kalarus, Z., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Odinsova, S., Arhipova, T., Kazakevich, E., Serdechnaya, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Polovina, M., Potpara, T., Vujisic-Tesic, B., Nedeljkovic, M., Zlatar, M., Asanin, M., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Shah, D., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Diker, E., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Lane, D., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., Lip, G. Y. H., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O’Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Laboratory Medicine, Cardiology, and ACS - Heart failure & arrhythmias
Subjects: Oral, Male, Aging, Administration, Oral, frailty, Frailty/chemically induced, outcomes, Europe/epidemiology, older people, Risk Factors, atrial fibrillation, chronicity, epidemiology, oral anticoagulant therapy, Aged, Anticoagulants, Europe, Female, Humans, Quality of Life, Registries, Atrial Fibrillation, Frailty, Stroke, Atrial Fibrillation/diagnosis, General Medicine, Administration, Geriatrics and Gerontology, Anticoagulants/adverse effects, Stroke/complications
Abstract: Background Frailty is a medical syndrome characterised by reduced physiological reserve and increased vulnerability to stressors. Data regarding the relationship between frailty and atrial fibrillation (AF) are still inconsistent. Objectives We aim to perform a comprehensive evaluation of frailty in a large European cohort of AF patients. Methods A 40-item frailty index (FI) was built according to the accumulation of deficits model in the AF patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry. Association of baseline characteristics, clinical management, quality of life, healthcare resources use and risk of outcomes with frailty was examined. Results Among 10,177 patients [mean age (standard deviation) 69.0 (11.4) years, 4,103 (40.3%) females], 6,066 (59.6%) were pre-frail and 2,172 (21.3%) were frail, whereas only 1,939 (19.1%) were considered robust. Baseline thromboembolic and bleeding risks were independently associated with increasing FI. Frail patients with AF were less likely to be treated with oral anticoagulants (OACs) (odds ratio 0.70, 95% confidence interval 0.55–0.89), especially with non-vitamin K antagonist OACs and managed with a rhythm control strategy, compared with robust patients. Increasing frailty was associated with a higher risk for all outcomes examined, with a non-linear exponential relationship. The use of OAC was associated with a lower risk of outcomes, except in patients with very/extremely high frailty. Conclusions In this large cohort of AF patients, there was a high burden of frailty, influencing clinical management and risk of adverse outcomes. The clinical benefit of OAC is maintained in patients with high frailty, but not in very high/extremely frail ones.
Published: 2022
Full Text: View/download PDF

33. Clinical utility and prognostic implications of the novel 4S-AF scheme to characterize and evaluate patients with atrial fibrillation:a report from ESC-EHRA EORP-AF Long-Term General Registry

Author: Ding, Wern Yew, Proietti, Marco, Boriani, Giuseppe, Fauchier, Laurent, Blomström-Lundqvist, Carina, Marin, Francisco, Potpara, Tatjana S., Lip, Gregory Y. H., Boriani, G., Lip, G. Y. H., Tavazzi, L., Maggioni, A. P., Dan, G. A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K. A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-ŁUć, M., Bujak, W., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stȩpień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, C. F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Mijatovic, S. A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Ozcan, O. T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Laboratory Medicine, Cardiology, and ACS - Heart failure & arrhythmias
Subjects: Characterization, Bleeding, 4S-AF, Atrial fibrillation, Classification, EORP-AF registry, Mortality, Prognostic implications, Stroke, Thromboembolism, Validation, Anticoagulants, Hemorrhage, Humans, Prognosis, Registries, Risk Factors, Atrial Fibrillation, Brain Ischemia, Ischemic Stroke, Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Aims The 4S-AF classification scheme comprises of four domains: stroke risk (St), symptoms (Sy), severity of atrial fibrillation (AF) burden (Sb), and substrate (Su). We sought to examine the implementation of the 4S-AF scheme in the EORP-AF General Long-Term Registry and compare outcomes in AF patients according to the 4S-AF-led decision-making process. Methods and results Atrial fibrillation patients from 250 centres across 27 European countries were included. A 4S-AF score was calculated as the sum of each domain with a maximum score of 9. Of 6321 patients, 8.4% had low (St), 47.5% EHRA I (Sy), 40.5% newly diagnosed or paroxysmal AF (Sb), and 5.1% no cardiovascular risk factors or left atrial enlargement (Su). Median follow-up was 24 months. Using multivariable Cox regression analysis, independent predictors of all-cause mortality were (St) [adjusted hazard ratio (aHR) 8.21, 95% confidence interval (CI): 2.60–25.9], (Sb) (aHR 1.21, 95% CI: 1.08–1.35), and (Su) (aHR 1.27, 95% CI: 1.14–1.41). For CV mortality and any thromboembolic event, only (Su) (aHR 1.73, 95% CI: 1.45–2.06) and (Sy) (aHR 1.29, 95% CI: 1.00–1.66) were statistically significant, respectively. None of the domains were independently linked to ischaemic stroke or major bleeding. Higher 4S-AF score was related to a significant increase in all-cause mortality, CV mortality, any thromboembolic event, and ischaemic stroke but not major bleeding. Treatment of all 4S-AF domains was associated with an independent decrease in all-cause mortality (aHR 0.71, 95% CI: 0.55–0.92). For each 4S-AF domain left untreated, the risk of all-cause mortality increased substantially (aHR 1.35, 95% CI: 1.16–1.56). Conclusion Implementation of the novel 4S-AF scheme is feasible, and treatment decisions based on this scheme improve mortality rates in AF.
Published: 2022
Full Text: View/download PDF

34. LUX Cryogenics and Circulation

Author: Bradley, A.W., Akerib, D.S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Cahn, S.B., Carmona-Benitez, M.C., Carr, D., Chapman, J.J., Clark, K., Classen, T., Coffey, T., Dazeley, S., de Viveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C.H., Fiorucci, S., Gaitskell, R.J., Gibson, K.R., Hall, C., Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R.G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Lesko, K., Lindote, A., Lopes, M.I., Lyashenko, A., Malling, D.C., Mannino, R., McKinsey, D., Mei, D., Mock, J., Morii, M., Nelson, H., Neves, F., Nikkel, J.A., Pangilinan, M., Phelps, P., Cunha, J. Pinto da, Shutt, T., Silva, C., Skulski, W., Solovov, V.N., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J.R., Walsh, N., Webb, R., White, J.T., Wlasenko, M., Wolfs, F.L.H., Woods, M., and Zhang, C.
Published: 2012
Full Text: View/download PDF

35. Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Author: Proietti, M., Vitolo, M., Harrison, S. L., Lane, D. A., Fauchier, L., Marin, F., Nabauer, M., Potpara, T. S., Dan, G. -A., Boriani, G., Lip, G. Y. H., Boriani (Chair), G., Tavazzi, L., Maggioni, A. P., Potpara, T., Kalarus, Z., Ferrari, R., Shantsila, A., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., Garcia Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E. N., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M. R., Crijns, H., Erkuner, O., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zera, E., Ekmekciu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubickova, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Veno, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castano, S., Cheggour, S., Poulard, J., Mouquet, V., Leparree, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassaliere, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefevre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Gloggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Koster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Fortsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Landle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hotz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schon, B., Schon, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mroz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kolodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Zieminska-Luc, M., Bujak, W., Sliwinski, A., Grech, A., Morka, J., Petrykowska, K., Prasal, M., Hordynski, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Wozniak, P., Chlebus, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kazmierczak, J., Przybylska, A., Skorek, E., Blaszczyk, H., Stepien, M., Szabowski, S., Krysiak, W., Szymanska, M., Karasinski, J., Blicharz, J., Skura, M., Halas, K., Michalczyk, L., Orski, Z., Krzyzanowski, K., Skrobowski, A., Zielinski, L., Tomaszewska-Kiecana, M., Dluzniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tyminska, A., Ozieranski, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandao Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragao, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhaes, P., Fontes, P., Leao, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Loachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Polovina, M., Vujisic-Tesic, B., Nedeljkovic, M., Zlatar, M., Asanin, M., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Kovacevic, S., Garcia Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldan Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Pinero, E., Manzano Fernandez, S., Romero Aniorte, A., Veliz Martinez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., Garcia-Bolao, I., Bertomeu Gonzalez, V., Otero-Ravina, F., Garcia Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koc, M., Onrat, E., Dural, I. E., Yilmaz, K., Ozin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Senoo, K., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., Mcmahon, S., Lip, G., Mcdonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., Mcskeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., Mckie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., Mckinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., Mckenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Proietti M, Vitolo M, Harrison SL, Lane DA, Fauchier L, Marin F, Nabauer M, Potpara TS, Dan GA, Boriani G, Lip GYH, ESC-EHRA EORP-AF Long-Term General Registry Investigators, Diemberger I, Ziacchi M, Frisoni J, Cardiology, ACS - Heart failure & arrhythmias, Graduate School, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de cardiologie
Subjects: Registrie, Research Report, medicine.medical_specialty, Major adverse outcome, Cardiovascular risk factors, Cluster analysis, Risk Factors, Internal medicine, Clinical phenotype, Atrial Fibrillation, Epidemiology, Humans, Medicine, Registries, Cluster analysi, Atrial fibrillation, Clinical management, Clinical phenotypes, Major adverse outcomes, Phenotype, business.industry, Proportional hazards model, Risk Factor, Hazard ratio, General Medicine, medicine.disease, Confidence interval, Cohort, Observational study, business, Research Article, Human
Abstract: Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients’ prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P < .001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27–3.62; HR 3.42, 95%CI 2.72–4.31; HR 2.79, 95%CI 2.32–3.35), and Cluster 1 (HR 1.88, 95%CI 1.48–2.38; HR 2.50, 95%CI 1.98–3.15; HR 2.09, 95%CI 1.74–2.51) reported a higher risk for the three outcomes respectively. Conclusions In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes.
Published: 2021
Full Text: View/download PDF

36. Improving the Self Reporting of Tobacco Use: Results of a Factorial Experiment

Author: Cowling, D. W., Johnson, T. P., Holbrook, B. C., Warnecke, R. B., and Tang, H.
Published: 2003

37. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, Federica, Fagiuoli, Stefano, Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, Luca, Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, Maria Rosaria, Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Donato F., Fagiuoli S., Miele L. (ORCID:0000-0003-3464-0068), Vinci M., Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, Federica, Fagiuoli, Stefano, Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, Luca, Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, Maria Rosaria, Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Donato F., Fagiuoli S., Miele L. (ORCID:0000-0003-3464-0068), and Vinci M.
Abstract: Background & Aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10–4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10–6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028–1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09–1.26; P = 9.93 × 10–8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10–9; OR, 1.33; 95% CI, 1.21–1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

38. Efficiency of finding muon track trigger primitives in CMS cathode strip chambers

Author: Acosta, D., Adam, A., Andreev, V., Apollinari, G., Baek, Y., Banicz, K., Barashko, V., Barberis, E., Bartalini, P., Bloch, I., Boeriu, O., Bondar, N., Breedon, R., Bujak, A., Bylsma, B., Chen, M., Clare, R., Cline, D., Cousins, R., Cox, P.T., Denisov, A., Drozdetskiy, A., Durkin, S., Eartly, D., Ershov, Yu., Ferguson, T., Fortin, D., Geurts, F., Gilmore, J., Golovtsov, V., Golutvin, I., Golyash, A., Gu, J., Gutay, L., Hauser, J., He, K., Holbrook, B., Holmes, D., Ignatenko, M., Ippolito, N., Ivanov, Yu., Jiang, C., Kao, S.-C., Karjavin, V., Khabarov, S., Killewald, P., Ko, W., Kotov, K., Korytov, A., Kozhevnikov, Yu., Lanaro, A., Levchenko, P., Ling, T.Y., Liu, J., Loveless, R., Lusin, S., Madorsky, A., Matveev, M., Medved, S., Mitselmakher, G., Moisenz, P., Padley, B.P., Pakhotin, Yu., Pal, I., Perelygin, V., Petrunin, A., Pischalnikov, Yu., Pivarsky, J., Prokofiev, O., Rakness, G., Roberts, J., Roe, A., Safonov, A., Schetkovsky, A., Schipunov, L., Schmitt, M., Scurlock, B., Sknar, V., Stoynev, S., Sulimov, V., Sun, H., Sytnik, V., Tchekhovski, V., Terentyev, N., Tripathi, M., Tucker, J., Tumanov, A., Uvarov, L., Valuev, V., Vassiliev, S., Vavilov, S., Velichko, G., Volkov, S., von der Mey, M., Vorobiev, I., Vorobyev, A., Vorobyev, An., Wang, D., Williams, G.L., Yatsura, V., Zarubin, A., Zhao, W., Zheng, Y., Zhmakin, G., Zhu, Z., and Zilizi, G.
Published: 2008
Full Text: View/download PDF

39. Sensors for the CDF Run2b silicon detector

Author: Akimoto, T., Aoki, M., Azzi, P., Bacchetta, N., Behari, S., Benjamin, D., Bisello, D., Bolla, G., Booth, P., Bortoletto, D., Burghard, A., Busetto, G., Cabrera, S., Canepa, A., Cardoso, G., Chertok, M., Ciobanu, C.I., Cooke, P., Derylo, G., Fang, I., Feng, E.J., Fernandez, J.P., Flaugher, B., Freeman, J., Galtieri, L., Galyardt, J., Garcia-Sciveres, M., Giurgiu, G., Gorelov, I., Haber, C., Hale, D., Hara, K., Harr, R., Hill, C., Hoeferkamp, M., Hoff, J., Holbrook, B., Hong, S.C., Hrycyk, M., Hsiung, T.H., Incandela, J., Jeon, E.J., Joo, K.K., Junk, T., Kahkola, H., Karjalainen, S., Kim, S., Kobayashi, K., Kong, D.J., Krieger, B., Kruse, M., Kyre, S., Lander, R., Landry, T., Lauhakangas, R., Lee, J., Lu, R.-S., Lujan, P.J., Lukens, P., Mandelli, E., Manea, C., Maksimovic, P., Merkel, P., Min, S.N., Moccia, S., Nakamura, Y., Nakano, I., Naoumov, D., Nelson, T., Nord, B., Novak, J., Okusawa, T., Orava, R., Orlov, Y., Osterberg, K., Pantano, D., Pavlicek, V., Pellett, D., Pursley, J., Riipinen, P., Schuyler, B., Seidel, S., Shenai, A., Soha, A., Stuart, D., Tanaka, R., Tavi, M., Von der Lippe, H., Walder, J.-P., Wang, Z., Watje, P., Weber, M., Wester, W., Yamamoto, Kenichi, Yang, Y.C., Yao, W., Yarema, R., Yoshitama, H., Yun, J.C., Zetti, F., Zimmerman, T., Zimmermann, S., and Zucchelli, S.
Subjects: Hamamatsu Photonic Systems -- Product development, Silicon diodes -- Product development, Photographic industry -- Product development, Sensors -- Usage, Business, Electronics, Electronics and electrical industries
Abstract: We describe the characteristics of silicon microstrip sensors fabricated by Hamamatsu Photonics for the CDF Run 2b silicon detector. A total of 953 sensors, including 117 prototype sensors, have been produced and tested. Five sensors were irradiated with neutrons up to 1.4 x [10.sup.14] n/[cm.sup.2] as a part of the sensor quality assurance program. The electrical and mechanical characteristics are found to be superior in all aspects and fulfill our specifications. We comment on charge-up susceptibility of the sensors that employ a (100) crystal structure.
Published: 2004

40. CDF Run IIb silicon detector: electrical performance and deadtime-less operation

Author: Akimoto, T., Aoki, M., Azzi, P., Bacchetta, N., Behari, S., Benjamin, D., Bisello, D., Bolla, G., Bortoletto, D., Busetto, G., Cabrera, S., Canepa, A., Cardoso, G., Chertok, M., Ciobanu, C.I., Derylo, G., Fang, I., Feng, E.J., Fernandez, J.P., Flaugher, B., Freeman, J., Galtieri, L., Galyardt, J., Garcia-Sciveres, M., Giurgiu, G., Haber, C., Hale, D., Hara, K., Harr, R., Hill, C., Hoff, J., Holbrook, B., Hong, S.C., Hrycyk, M., Hsiung, T.H., Incandela, J., Jeon, E.J., Joo, K.K., Junk, T., Kahkola, H., Karjalainen, S., Kim, S., Kobayashi, K., Kong, D.J., Krieger, B., Kruse, M., Kuznetsova, N., Kyre, S., Lander, R., Landry, T., Lauhakangas, R., Lee, J., Lu, R.-S., Lujan, P., Lukens, P., Mandelli, E., Manea, C., Maksimovic, P., Merkel, P., Min, S.N., Moccia, S., Nakano, I., Nelson, T., Nord, B., Novak, J., Okusawa, T., Orava, R., Orlov, Y., Osterberg, K., Pantano, D., Pavlicek, V., Pellett, D., Pursley, J., Riipinen, P., Schuyler, B., Shenai, A., Soha, A., Stuart, D., Tanaka, R., Tavi, M., Von der Lippe, H., Walder, J.-P., Wang, Z., Weber, Marc, Wester, W., Yamamoto, Kenichi, Yang, Y.C., Yao, W., Yarema, R., Yun, J.C., Zetti, F., Zimmerman, T., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear physics -- Research, Detectors, Business, Electronics, Electronics and electrical industries
Abstract: The main building block and readout unit of the planned CDF Run IIb silicon detector is a 'stave,' a highly integrated mechanical, thermal, and electrical structure. One of its characteristic features is a copper-on-Kapton flexible cable for power, high voltage, data transmission, and control signals that is placed directly below the silicon microstrip sensors. The dense packaging makes deadtime-less operation of the stave a challenge since coupling of bus cable activity into the silicon sensors must be suppressed efficiently. The stave design features relevant for deadtime-less operation are discussed. The electrical performance achieved with stave prototypes is presented. Index Terms--CDF, deadtime-less, Run IIb, silicon tracker, SVX4.
Published: 2004

41. The CDF Run IIb Silicon Detector: Design, preproduction, and performance

Author: Akimoto, T., Aoki, M., Azzi, P., Bacchetta, N., Behari, S., Benjamin, D., Bisello, D., Bolla, G., Bortoletto, D., Burghard, A., Busetto, G., Cabrera, S., Canepa, A., Cardoso, G., Chertok, M., Ciobanu, C.I., Derylo, G., Fang, I., Feng, E.J., Fernandez, J.P., Flaugher, B., Freeman, J., Galtieri, L., Galyardt, J., Garcia-Sciveres, M., Giurgiu, G., Gorelov, I., Haber, C., Hale, D., Hara, K., Harr, R., Hill, C., Hoeferkamp, M., Hoff, J., Holbrook, B., Hong, S.C., Hrycyk, M., Hsiung, T.H., Incandela, J., Jeon, E.J., Joo, K.K., Junk, T., Kahkola, H., Karjalainen, S., Kim, S., Kobayashi, K., Kong, D.J., Krieger, B., Kruse, M., Kuznetsova, N., Kyre, S., Lander, R., Landry, T., Lauhakangas, R., Lee, J., Lu, R.-S., Lujan, P., Lukens, P., Mandelli, E., Manea, C., Maksimovic, P., Merkel, P., Min, S.N., Moccia, S., Nakano, I., Naoumov, D., Nelson, T., Nord, B., Novak, J., Okusawa, T., Orava, R., Orlov, Y., Osterberg, K., Pantano, D., Pavlicek, V., Pellett, D., Pursley, J., Riipinen, P., Schuyler, B., Seidel, S., Shenai, A., Soha, A., Stuart, D., Tanaka, R., Tavi, M., Von der Lippe, H., Walder, J.-P., Wang, Z., Watje, P., Weber, Marc, Wester, W., Yamamoto, K., Yang, Y.C., Yao, W., Yarema, R., Yun, J.C., Zetti, F., Zimmerman, T., Zimmermann, S., and Zucchelli, S.
Published: 2006
Full Text: View/download PDF

42. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Akerib, D. S., primary, Akerlof, C. W., additional, Akimov, D. Yu., additional, Alquahtani, A., additional, Alsum, S. K., additional, Anderson, T. J., additional, Angelides, N., additional, Araújo, H. M., additional, Arbuckle, A., additional, Armstrong, J. E., additional, Arthurs, M., additional, Auyeung, H., additional, Aviles, S., additional, Bai, X., additional, Bailey, A. J., additional, Balajthy, J., additional, Balashov, S., additional, Bang, J., additional, Barry, M. J., additional, Bauer, D., additional, Bauer, P., additional, Baxter, A., additional, Belle, J., additional, Beltrame, P., additional, Bensinger, J., additional, Benson, T., additional, Bernard, E. P., additional, Bernstein, A., additional, Bhatti, A., additional, Biekert, A., additional, Biesiadzinski, T. P., additional, Birch, H. J., additional, Birrittella, B., additional, Boast, K. E., additional, Bolozdynya, A. I., additional, Boulton, E. M., additional, Boxer, B., additional, Bramante, R., additional, Branson, S., additional, Brás, P., additional, Breidenbach, M., additional, Brew, C. A. J., additional, Buckley, J. H., additional, Bugaev, V. V., additional, Bunker, R., additional, Burdin, S., additional, Busenitz, J. K., additional, Cabrita, R., additional, Campbell, J. S., additional, Carels, C., additional, Carlsmith, D. L., additional, Carlson, B., additional, Carmona-Benitez, M. C., additional, Cascella, M., additional, Chan, C., additional, Cherwinka, J. J., additional, Chiller, A. A., additional, Chiller, C., additional, Chott, N. I., additional, Cole, A., additional, Coleman, J., additional, Colling, D., additional, Conley, R. A., additional, Cottle, A., additional, Coughlen, R., additional, Cox, G., additional, Craddock, W. W., additional, Curran, D., additional, Currie, A., additional, Cutter, J. E., additional, da Cunha, J. P., additional, Dahl, C. E., additional, Dardin, S., additional, Dasu, S., additional, Davis, J., additional, Davison, T. J. R., additional, de Viveiros, L., additional, Decheine, N., additional, Dobi, A., additional, Dobson, J. E. Y., additional, Druszkiewicz, E., additional, Dushkin, A., additional, Edberg, T. K., additional, Edwards, W. R., additional, Edwards, B. N., additional, Edwards, J., additional, Elnimr, M. M., additional, Emmet, W. T., additional, Eriksen, S. R., additional, Faham, C. H., additional, Fan, A., additional, Fayer, S., additional, Fiorucci, S., additional, Flaecher, H., additional, Florang, I. M. Fogarty, additional, Ford, P., additional, Francis, V. B., additional, Fraser, E. D., additional, Froborg, F., additional, Fruth, T., additional, Gaitskell, R. J., additional, Gantos, N. J., additional, Garcia, D., additional, Gehman, V. M., additional, Gelfand, R., additional, Genovesi, J., additional, Gerhard, R. M., additional, Ghag, C., additional, Gibson, E., additional, Gilchriese, M. G. D., additional, Gokhale, S., additional, Gomber, B., additional, Gonda, T. G., additional, Greenall, A., additional, Greenwood, S., additional, Gregerson, G., additional, van der Grinten, M. G. D., additional, Gwilliam, C. B., additional, Hall, C. R., additional, Hamilton, D., additional, Hans, S., additional, Hanzel, K., additional, Harrington, T., additional, Harrison, A., additional, Harrison, J., additional, Hasselkus, C., additional, Haselschwardt, S. J., additional, Hemer, D., additional, Hertel, S. A., additional, Heise, J., additional, Hillbrand, S., additional, Hitchcock, O., additional, Hjemfelt, C., additional, Hoff, M. D., additional, Holbrook, B., additional, Holtom, E., additional, Hor, J. Y-K., additional, Horn, M., additional, Huang, D. Q., additional, Hurteau, T. W., additional, Ignarra, C. M., additional, Irving, M. N., additional, Jacobsen, R. G., additional, Jahangir, O., additional, Jeffery, S. N., additional, Ji, W., additional, Johnson, M., additional, Johnson, J., additional, Johnson, P., additional, Jones, W. G., additional, Kaboth, A. C., additional, Kamaha, A., additional, Kamdin, K., additional, Kasey, V., additional, Kazkaz, K., additional, Keefner, J., additional, Khaitan, D., additional, Khaleeq, M., additional, Khazov, A., additional, Khromov, A. V., additional, Khurana, I., additional, Kim, Y. D., additional, Kim, W. T., additional, Kocher, C. D., additional, Kodroff, D., additional, Konovalov, A. M., additional, Korley, L., additional, Korolkova, E. V., additional, Koyuncu, M., additional, Kras, J., additional, Kraus, H., additional, Kravitz, S. W., additional, Krebs, H. J., additional, Kreczko, L., additional, Krikler, B., additional, Kudryavtsev, V. A., additional, Kumpan, A. V., additional, Kyre, S., additional, Lambert, A. R., additional, Landerud, B., additional, Larsen, N. A., additional, Laundrie, A., additional, Leason, E. A., additional, Lee, H. S., additional, Lee, J., additional, Lee, C., additional, Lenardo, B. G., additional, Leonard, D. S., additional, Leonard, R., additional, Lesko, K. T., additional, Levy, C., additional, Li, J., additional, Liu, Y., additional, Liao, J., additional, Liao, F.-T., additional, Lin, J., additional, Lindote, A., additional, Linehan, R., additional, Lippincott, W. H., additional, Liu, R., additional, Liu, X., additional, Loniewski, C., additional, Lopes, M. I., additional, Lopez-Asamar, E., additional, Paredes, B. López, additional, Lorenzon, W., additional, Lucero, D., additional, Luitz, S., additional, Lyle, J. M., additional, Lynch, C., additional, Majewski, P. A., additional, Makkinje, J., additional, Malling, D. C., additional, Manalaysay, A., additional, Manenti, L., additional, Mannino, R. L., additional, Marangou, N., additional, Markley, D. J., additional, MarrLaundrie, P., additional, Martin, T. J., additional, Marzioni, M. F., additional, Maupin, C., additional, McConnell, C. T., additional, McKinsey, D. N., additional, McLaughlin, J., additional, Mei, D.-M., additional, Meng, Y., additional, Miller, E. H., additional, Minaker, Z. J., additional, Mizrachi, E., additional, Mock, J., additional, Molash, D., additional, Monte, A., additional, Monzani, M. E., additional, Morad, J. A., additional, Morrison, E., additional, Mount, B. J., additional, Murphy, A. St. J., additional, Naim, D., additional, Naylor, A., additional, Nedlik, C., additional, Nehrkorn, C., additional, Nelson, H. N., additional, Nesbit, J., additional, Neves, F., additional, Nikkel, J. A., additional, Nikoleyczik, J. A., additional, Nilima, A., additional, O’Dell, J., additional, Oh, H., additional, O’Neill, F. G., additional, O’Sullivan, K., additional, Olcina, I., additional, Olevitch, M. A., additional, Oliver-Mallory, K. C., additional, Oxborough, L., additional, Pagac, A., additional, Pagenkopf, D., additional, Pal, S., additional, Palladino, K. J., additional, Palmaccio, V. M., additional, Palmer, J., additional, Pangilinan, M., additional, Parveen, N., additional, Patton, S. J., additional, Pease, E. K., additional, Penning, B. P., additional, Pereira, G., additional, Pereira, C., additional, Peterson, I. B., additional, Piepke, A., additional, Pierson, S., additional, Powell, S., additional, Preece, R. M., additional, Pushkin, K., additional, Qie, Y., additional, Racine, M., additional, Ratcliff, B. N., additional, Reichenbacher, J., additional, Reichhart, L., additional, Rhyne, C. A., additional, Richards, A., additional, Riffard, Q., additional, Rischbieter, G. R. C., additional, Rodrigues, J. P., additional, Rose, H. J., additional, Rosero, R., additional, Rossiter, P., additional, Rucinski, R., additional, Rutherford, G., additional, Saba, J. S., additional, Sabarots, L., additional, Santone, D., additional, Sarychev, M., additional, Sazzad, A. B. M. R., additional, Schnee, R. W., additional, Schubnell, M., additional, Scovell, P. R., additional, Severson, M., additional, Seymour, D., additional, Shaw, S., additional, Shutt, G. W., additional, Shutt, T. A., additional, Silk, J. J., additional, Silva, C., additional, Skarpaas, K., additional, Skulski, W., additional, Smith, A. R., additional, Smith, R. J., additional, Smith, R. E., additional, So, J., additional, Solmaz, M., additional, Solovov, V. N., additional, Sorensen, P., additional, Sosnovtsev, V. V., additional, Stancu, I., additional, Stark, M. R., additional, Stephenson, S., additional, Stern, N., additional, Stevens, A., additional, Stiegler, T. M., additional, Stifter, K., additional, Studley, R., additional, Sumner, T. J., additional, Sundarnath, K., additional, Sutcliffe, P., additional, Swanson, N., additional, Szydagis, M., additional, Tan, M., additional, Taylor, W. C., additional, Taylor, R., additional, Taylor, D. J., additional, Temples, D., additional, Tennyson, B. P., additional, Terman, P. A., additional, Thomas, K. J., additional, Thomson, J. A., additional, Tiedt, D. R., additional, Timalsina, M., additional, To, W. H., additional, Tomás, A., additional, Tope, T. E., additional, Tripathi, M., additional, Tronstad, D. R., additional, Tull, C. E., additional, Turner, W., additional, Tvrznikova, L., additional, Utes, M., additional, Utku, U., additional, Uvarov, S., additional, Va’vra, J., additional, Vacheret, A., additional, Vaitkus, A., additional, Verbus, J. R., additional, Vietanen, T., additional, Voirin, E., additional, Vuosalo, C. O., additional, Walcott, S., additional, Waldron, W. L., additional, Walker, K., additional, Wang, J. J., additional, Wang, R., additional, Wang, L., additional, Wang, W., additional, Wang, Y., additional, Watson, J. R., additional, Migneault, J., additional, Weatherly, S., additional, Webb, R. C., additional, Wei, W.-Z., additional, While, M., additional, White, R. G., additional, White, J. T., additional, White, D. T., additional, Whitis, T. J., additional, Wisniewski, W. J., additional, Wilson, K., additional, Witherell, M. S., additional, Wolfs, F. L. H., additional, Wolfs, J. D., additional, Woodward, D., additional, Worm, S. D., additional, Xiang, X., additional, Xiao, Q., additional, Xu, J., additional, Yeh, M., additional, Yin, J., additional, Young, I., additional, Zhang, C., additional, and Zarzhitsky, P., additional
Published: 2020
Full Text: View/download PDF

43. Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry

Author: Zakine, Cyril, Garcia, Rodrigue, Narayanan, Kumar, Gandjbakhch, Estelle, Algalarrondo, Vincent, Lellouche, Nicolas, Perier, Marie-Cécile, Fauchier, Laurent, Gras, Daniel, Bordachar, Pierre, Piot, Olivier, Babuty, Dominique, Sadoul, Nicolas, Defaye, Pascal, Deharo, Jean-Claude, Klug, Didier, Leclercq, Christophe, Extramiana, Fabrice, Boveda, Serge, Marijon, Eloi, Maury, Philippe, Alonso, Christine, Anselme, Frederic, Hermida, Jean-Sylvain, Laurent, Gabriel, Mansourati, Jacques, Sacher, Frederic, Taieb, Jérôme, Boriani, Giuseppe, Proietti, Marco, Laroche, Cécile, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana, Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo, Lip, Gregory, Dan, G-A, Goda, A, Mairesse, G, Shalganov, T, Antoniades, L, Taborsky, M, Riahi, S, Muda, P, García Bolao, I, Etsadashvili, K, Simantirakis, E, Haim, M, Azhari, A, Najafian, J, Santini, M, Mirrakhimov, E, a Kulzida, K, Erglis, A, Poposka, L, Burg, M, Crijns, H, Erküner, Ö, Atar, D, Lenarczyk, R, Martins Oliveira, M, Shah, D, Serdechnaya, E, Diker, E, Lane, D, Zëra, E, Ekmekçiu, U, Paparisto, V, Tase, M, Gjergo, H, Dragoti, J, Ciutea, M, Ahadi, N, El Husseini, Z, Raepers, M, Leroy, J, Haushan, P, Jourdan, A, Lepiece, C, Desteghe, L, Vijgen, J, Koopman, P, van Genechten, G, Heidbuchel, H, Boussy, T, de Coninck, M, van Eeckhoutte, H, Bouckaert, N, Friart, A, Boreux, J, Arend, C, Evrard, P, Stefan, L, Hoffer, E, Herzet, J, Massoz, M, Celentano, C, Sprynger, M, Pierard, L, Melon, P, van Hauwaert, B, Kuppens, C, Faes, D, van Lier, D, van Dorpe, A, Gerardy, A, Deceuninck, O, Xhaet, O, Dormal, F, Ballant, E, Blommaert, D, Yakova, D, Hristov, M, Yncheva, T, Stancheva, N, Tisheva, S, Tokmakova, M, Nikolov, F, Gencheva, D, Kunev, B, Stoyanov, M, Marchov, D, Gelev, V, Traykov, V, Kisheva, A, Tsvyatkov, H, Shtereva, R, Bakalska-Georgieva, S, Slavcheva, S, Yotov, Y, Kubíčková, M, Marni Joensen, A, Gammelmark, A, Hvilsted Rasmussen, L, Dinesen, P, Krogh Venø, S, Sorensen, B, Korsgaard, A, Andersen, K, Fragtrup Hellum, C, Svenningsen, A, Nyvad, O, Wiggers, P, May, O, Aarup, A, Graversen, B, Jensen, L, Andersen, M, Svejgaard, M, Vester, S, Hansen, S, Lynggaard, V, Ciudad, M, Vettus, R, Maestre, A, Castaño, S, Cheggour, S, Poulard, J, Mouquet, V, Leparrée, S, Bouet, J, Doucy, A, Duquenne, H, Furber, A, Dupuis, J, Rautureau, J, Font, M, Damiano, P, Lacrimini, M, Abalea, J, Boismal, S, Menez, T, Range, G, Gorka, H, Laure, C, Vassalière, C, Elbaz, N, Djouadi, K, Roubille, F, Dietz, D, Davy, J, Granier, M, Winum, P, Leperchois-Jacquey, C, Kassim, H, Le Heuzey, J, Fedida, J, Maupain, C, Himbert, C, Hidden-Lucet, F, Duthoit, G, Badenco, N, Chastre, T, Waintraub, X, Oudihat, M, Lacoste, J, Stephan, C, Bader, H, Delarche, N, Giry, L, Arnaud, D, Lopez, C, Boury, F, Brunello, I, Lefèvre, M, Mingam, R, Haissaguerre, M, Le Bidan, M, Pavin, D, Le Moal, V, Beitar, T, Martel, I, Schmid, A, Sadki, N, Romeyer-Bouchard, C, da Costa, A, Arnault, I, Boyer, M, Piat, C, Lozance, N, Nastevska, S, Doneva, A, Fortomaroska Milevska, B, Sheshoski, B, Petroska, K, Taneska, N, Bakrecheski, N, Lazarovska, K, Jovevska, S, Ristovski, V, Antovski, A, Lazarova, E, Kotlar, I, Taleski, J, Kedev, S, Zlatanovik, N, Jordanova, S, Bajraktarova Proseva, T, Doncovska, S, Maisuradze, D, Esakia, A, Sagirashvili, E, Lartsuliani, K, Natelashvili, N, Gumberidze, N, Gvenetadze, R, Gotonelia, N, Kuridze, N, Papiashvili, G, Menabde, I, Glöggler, S, Napp, A, Lebherz, C, Romero, H, Schmitz, K, Berger, M, Zink, M, Köster, S, Sachse, J, Vonderhagen, E, Soiron, G, Mischke, K, Reith, R, Schneider, M, Rieker, W, Boscher, D, Taschareck, A, Beer, A, Oster, D, Ritter, O, Adamczewski, J, Walter, S, Frommhold, A, Luckner, E, Richter, J, Schellner, M, Landgraf, S, Bartholome, S, Naumann, R, Schoeler, J, Westermeier, D, William, F, Wilhelm, K, Maerkl, M, Oekinghaus, R, Denart, M, Kriete, M, Tebbe, U, Scheibner, T, Gruber, M, Gerlach, A, Beckendorf, C, Anneken, L, Arnold, M, Lengerer, S, Bal, Z, Uecker, C, Förtsch, H, Fechner, S, Mages, V, Martens, E, Methe, H, Schmidt, T, Schaeffer, B, Hoffmann, B, Moser, J, Heitmann, K, Willems, S, Klaus, C, Lange, I, Durak, M, Esen, E, Mibach, F, Mibach, H, Utech, A, Gabelmann, M, Stumm, R, Ländle, V, Gartner, C, Goerg, C, Kaul, N, Messer, S, Burkhardt, D, Sander, C, Orthen, R, Kaes, S, Baumer, A, Dodos, F, Barth, A, Schaeffer, G, Gaertner, J, Winkler, J, Fahrig, A, Aring, J, Wenzel, I, Steiner, S, Kliesch, A, Kratz, E, Winter, K, Schneider, P, Haag, A, Mutscher, I, Bosch, R, Taggeselle, J, Meixner, S, Schnabel, A, Shamalla, A, Hötz, H, Korinth, A, Rheinert, C, Mehltretter, G, Schön, B, Schön, N, Starflinger, A, Englmann, E, Baytok, G, Laschinger, T, Ritscher, G, Gerth, A, Dechering, D, Eckardt, L, Kuhlmann, M, Proskynitopoulos, N, Brunn, J, Foth, K, Axthelm, C, Hohensee, H, Eberhard, K, Turbanisch, S, Hassler, N, Koestler, A, Stenzel, G, Kschiwan, D, Schwefer, M, Neiner, S, Hettwer, S, Haeussler-Schuchardt, M, Degenhardt, R, Sennhenn, S, Brendel, M, Stoehr, A, Widjaja, W, Loehndorf, S, Logemann, A, Hoskamp, J, Grundt, J, Block, M, Ulrych, R, Reithmeier, A, Panagopoulos, V, Martignani, C, Bernucci, D, Fantecchi, E, Diemberger, I, Ziacchi, M, Biffi, M, Cimaglia, P, Frisoni, J, Giannini, I, Boni, S, Fumagalli, S, Pupo, S, Di Chiara, A, Mirone, P, Pesce, F, Zoccali, C, Malavasi, V, Mussagaliyeva, A, Ahyt, B, Salihova, Z, Koshum-Bayeva, K, Kerimkulova, A, Bairamukova, A, Lurina, B, Zuzans, R, Jegere, S, Mintale, I, Kupics, K, Jubele, K, Kalejs, O, Vanhear, K, Cachia, M, Abela, E, Warwicker, S, Tabone, T, Xuereb, R, Asanovic, D, Drakalovic, D, Vukmirovic, M, Pavlovic, N, Music, L, Bulatovic, N, Boskovic, A, Uiterwaal, H, Bijsterveld, N, de Groot, J, Neefs, J, van den Berg, N, Piersma, F, Wilde, A, Hagens, V, van Es, J, van Opstal, J, van Rennes, B, Verheij, H, Breukers, W, Tjeerdsma, G, Nijmeijer, R, Wegink, D, Binnema, R, Said, S, Philippens, S, van Doorn, W, Szili-Torok, T, Bhagwandien, R, Janse, P, Muskens, A, van Eck, M, Gevers, R, van Der Ven, N, Duygun, A, Rahel, B, Meeder, J, Vold, A, Holst Hansen, C, Engset, I, Dyduch-Fejklowicz, B, Koba, E, Cichocka, M, Sokal, A, Kubicius, A, Pruchniewicz, E, Kowalik-Sztylc, A, Czapla, W, Mróz, I, Kozlowski, M, Pawlowski, T, Tendera, M, Winiarska-Filipek, A, Fidyk, A, Slowikowski, A, Haberka, M, Lachor-Broda, M, Biedron, M, Gasior, Z, Kołodziej, M, Janion, M, Gorczyca-Michta, I, Wozakowska-Kaplon, B, Stasiak, M, Jakubowski, P, Ciurus, T, Drozdz, J, Simiera, M, Zajac, P, Wcislo, T, Zycinski, P, Kasprzak, J, Olejnik, A, Harc-Dyl, E, Miarka, J, Pasieka, M, Ziemińska-Łuć, M, Bujak, W, Śliwiński, A, Grech, A, Morka, J, Petrykowska, K, Prasał, M, Hordyński, G, Feusette, P, Lipski, P, Wester, A, Streb, W, Romanek, J, Woźniak, P, Chlebuś, M, Szafarz, P, Stanik, W, Zakrzewski, M, Kaźmierczak, J, Przybylska, A, Skorek, E, Błaszczyk, H, Stępień, M, Szabowski, S, Krysiak, W, Szymańska, M, Karasiński, J, Blicharz, J, Skura, M, Hałas, K, Michalczyk, L, Orski, Z, Krzyżanowski, K, Skrobowski, A, Zieliński, L, Tomaszewska-Kiecana, M, Dłużniewski, M, Kiliszek, M, Peller, M, Budnik, M, Balsam, P, Opolski, G, Tymińska, A, Ozierański, K, Wancerz, A, Borowiec, A, Majos, E, Dabrowski, R, Szwed, H, Musialik-Lydka, A, Leopold-Jadczyk, A, Jedrzejczyk-Patej, E, Koziel, M, Mazurek, M, Krzemien-Wolska, K, Starosta, P, Nowalany-Kozielska, E, Orzechowska, A, Szpot, M, Staszel, M, Almeida, S, Pereira, H, Brandão Alves, L, Miranda, R, Ribeiro, L, Costa, F, Morgado, F, Carmo, P, Galvao Santos, P, Bernardo, R, Adragão, P, Ferreira da Silva, G, Peres, M, Alves, M, Leal, M, Cordeiro, A, Magalhães, P, Fontes, P, Leão, S, Delgado, A, Costa, A, Marmelo, B, Rodrigues, B, Moreira, D, Santos, J, Santos, L, Terchet, A, Darabantiu, D, Mercea, S, Turcin Halka, V, Pop Moldovan, A, Gabor, A, Doka, B, Catanescu, G, Rus, H, Oboroceanu, L, Bobescu, E, Popescu, R, Dan, A, Buzea, A, Daha, I, Neuhoff, I, Baluta, M, Ploesteanu, R, Dumitrache, N, Vintila, M, Daraban, A, Japie, C, Badila, E, Tewelde, H, Hostiuc, M, Frunza, S, Tintea, E, Bartos, D, Ciobanu, A, Popescu, I, Toma, N, Gherghinescu, C, Cretu, D, Patrascu, N, Stoicescu, C, Udroiu, C, Bicescu, G, Vintila, V, Vinereanu, D, Cinteza, M, Rimbas, R, Grecu, M, Cozma, A, Boros, F, Ille, M, Tica, O, Tor, R, Corina, A, Jeewooth, A, Maria, B, Georgiana, C, Natalia, C, Alin, D, Dinu-Andrei, D, Livia, M, Daniela, R, Larisa, R, Umaar, S, Tamara, T, Ioachim Popescu, M, Nistor, D, Sus, I, Coborosanu, O, Alina-Ramona, N, Dan, R, Petrescu, L, Ionescu, G, Vacarescu, C, Goanta, E, Mangea, M, Ionac, A, Mornos, C, Cozma, D, Pescariu, S, Solodovnicova, E, Soldatova, I, Shutova, J, Tjuleneva, L, Zubova, T, Uskov, V, Obukhov, D, Rusanova, G, Isakova, N, Odinsova, S, Arhipova, T, Kazakevich, E, Zavyalova, O, Novikova, T, Riabaia, I, Zhigalov, S, Drozdova, E, Luchkina, I, Monogarova, Y, Hegya, D, Rodionova, L, Nevzorova, V, Lusanova, O, Arandjelovic, A, Toncev, D, Vukmirovic, L, Radisavljevic, M, Milanov, M, Sekularac, N, Zdravkovic, M, Hinic, S, Dimkovic, S, Acimovic, T, Saric, J, Radovanovic, S, Kocijancic, A, Obrenovic-Kircanski, B, Kalimanovska Ostric, D, Simic, D, Jovanovic, I, Petrovic, I, Polovina, M, Vukicevic, M, Tomasevic, M, Mujovic, N, Radivojevic, N, Petrovic, O, Aleksandric, S, Kovacevic, V, Mijatovic, Z, Ivanovic, B, Tesic, M, Ristic, A, Vujisic-Tesic, B, Nedeljkovic, M, Karadzic, A, Uscumlic, A, Prodanovic, M, Zlatar, M, Asanin, M, Bisenic, B, Vasic, V, Popovic, Z, Djikic, D, Sipic, M, Peric, V, Dejanovic, B, Milosevic, N, Backovic, S, Stevanovic, A, Andric, A, Pencic, B, Pavlovic-Kleut, M, Celic, V, Pavlovic, M, Petrovic, M, Vuleta, M, Petrovic, N, Simovic, S, Savovic, Z, Milanov, S, Davidovic, G, Iric-Cupic, V, Djordjevic, D, Damjanovic, M, Zdravkovic, S, Topic, V, Stanojevic, D, Randjelovic, M, Jankovic-Tomasevic, R, Atanaskovic, V, Antic, S, Simonovic, D, Stojanovic, M, Stojanovic, S, Mitic, V, Ilic, V, Petrovic, D, Deljanin Ilic, M, Ilic, S, Stoickov, V, Markovic, S, Mijatovic, A, Tanasic, D, Radakovic, G, Peranovic, J, Panic-Jelic, N, Vujadinovic, O, Pajic, P, Bekic, S, Kovacevic, S, García Fernandez, A, Perez Cabeza, A, Anguita, M, Tercedor Sanchez, L, Mau, E, Loayssa, J, Ayarra, M, Carpintero, M, Roldán Rabadan, I, Gil Ortega, M, Tello Montoliu, A, Orenes Piñero, E, Manzano Fernández, S, Romero Aniorte, A, Veliz Martínez, A, Quintana Giner, M, Ballesteros, G, Palacio, M, Alcalde, O, García-Bolao, I, Bertomeu Gonzalez, V, Otero-Raviña, F, García Seara, J, Gonzalez Juanatey, J, Dayal, N, Maziarski, P, Gentil-Baron, P, Koç, M, Onrat, E, Dural, I, Yilmaz, K, Özin, B, Tan Kurklu, S, Atmaca, Y, Canpolat, U, Tokgozoglu, L, Dolu, A, Demirtas, B, Sahin, D, Ozcan Celebi, O, Gagirci, G, Turk, U, Ari, H, Polat, N, Toprak, N, Sucu, M, Akin Serdar, O, Taha Alper, A, Kepez, A, Yuksel, Y, Uzunselvi, A, Yuksel, S, Sahin, M, Kayapinar, O, Ozcan, T, Kaya, H, Yilmaz, M, Kutlu, M, Demir, M, Gibbs, C, Kaminskiene, S, Bryce, M, Skinner, A, Belcher, G, Hunt, J, Stancombe, L, Holbrook, B, Peters, C, Tettersell, S, Shantsila, A, Senoo, K, Russell, K, Domingos, P, Hussain, S, Partridge, J, Haynes, R, Bahadur, S, Brown, R, Mcmahon, S, Mcdonald, J, Balachandran, K, Singh, R, Garg, S, Desai, H, Davies, K, Goddard, W, Galasko, G, Rahman, I, Chua, Y, Payne, O, Preston, S, Brennan, O, Pedley, L, Whiteside, C, Dickinson, C, Brown, J, Jones, K, Benham, L, Brady, R, Buchanan, L, Ashton, A, Crowther, H, Fairlamb, H, Thornthwaite, S, Relph, C, Mcskeane, A, Poultney, U, Kelsall, N, Rice, P, Wilson, T, Wrigley, M, Kaba, R, Patel, T, Young, E, Law, J, Runnett, C, Thomas, H, Mckie, H, Fuller, J, Pick, S, Sharp, A, Hunt, A, Thorpe, K, Hardman, C, Cusack, E, Adams, L, Hough, M, Keenan, S, Bowring, A, Watts, J, Zaman, J, Goffin, K, Nutt, H, Beerachee, Y, Featherstone, J, Mills, C, Pearson, J, Stephenson, L, Grant, S, Wilson, A, Hawksworth, C, Alam, I, Robinson, M, Ryan, S, Egdell, R, Gibson, E, Holland, M, Leonard, D, Mishra, B, Ahmad, S, Randall, H, Hill, J, Reid, L, George, M, Mckinley, S, Brockway, L, Milligan, W, Sobolewska, J, Muir, J, Tuckis, L, Winstanley, L, Jacob, P, Kaye, S, Morby, L, Jan, A, Sewell, T, Boos, C, Wadams, B, Cope, C, Jefferey, P, Andrews, N, Getty, A, Suttling, A, Turner, C, Hudson, K, Austin, R, Howe, S, Iqbal, R, Gandhi, N, Brophy, K, Mirza, P, Willard, E, Collins, S, Ndlovu, N, Subkovas, E, Karthikeyan, V, Waggett, L, Wood, A, Bolger, A, Stockport, J, Evans, L, Harman, E, Starling, J, Williams, L, Saul, V, Sinha, M, Bell, L, Tudgay, S, Kemp, S, Frost, L, Ingram, T, Loughlin, A, Adams, C, Adams, M, Hurford, F, Owen, C, Miller, C, Donaldson, D, Tivenan, H, Button, H, Nasser, A, Jhagra, O, Stidolph, B, Brown, C, Livingstone, C, Duffy, M, Madgwick, P, Roberts, P, Greenwood, E, Fletcher, L, Beveridge, M, Earles, S, Mckenzie, D, Beacock, D, Dayer, M, Seddon, M, Greenwell, D, Luxton, F, Venn, F, Mills, H, Rewbury, J, James, K, Roberts, K, Tonks, L, Felmeden, D, Taggu, W, Summerhayes, A, Hughes, D, Sutton, J, Felmeden, L, Khan, M, Walker, E, Norris, L, O'Donohoe, L, Mozid, A, Dymond, H, Lloyd-Jones, H, Saunders, G, Simmons, D, Coles, D, Cotterill, D, Beech, S, Kidd, S, Wrigley, B, Petkar, S, Smallwood, A, Jones, R, Radford, E, Milgate, S, Metherell, S, Cottam, V, Buckley, C, Broadley, A, Wood, D, Allison, J, Rennie, K, Balian, L, Howard, L, Pippard, L, Board, S, Pitt-Kerby, T, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Université de Montréal (UdeM), Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de cardiologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biospectroscopie Translationnelle - EA 7506 (BIOSPECT), Université de Reims Champagne-Ardenne (URCA), Service de Cardiologie B, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cardiac Stimulation and Rhythmology, CHU Grenoble, Department of Cardiology and Cardiovascular Surgery, CHU Michallon, Grenoble, France, CHU Marseille, CHU Lille, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique Pasteur, Clinique Pasteur [Toulouse], Service de cardiologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Ambroise Paré [AP-HP], Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Centre Hospitalier du Pays d'Aix, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Università degli Studi di Milano = University of Milan (UNIMI), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Liverpool, Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Universidad de Murcia, University of Belgrade [Belgrade], Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Silesian Medical University, Katowice, Poland, Maria Cecilia Hospital [Cotignola], Research Center [Associazione Nazionale Medici Cardiologi Ospedalieri] (ANMCO Research Center), Associazione Nazionale Medici Cardiologi Ospedalieri [Firenze] (ANMCO), Aalborg University [Denmark] (AAU), Abbott Vascular Int., Amgen Cardiovascular, Novartis Pharma AG, Sanofi, SERVIER, Atrial Fibrillation NETwork, AFNET, AstraZeneca, Bayer AG, Boehringer Ingelheim, Boston Scientific, The Bristol Myers Squibb and Pfizer Alliance, Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company, Gedeon Richter Plc., Menarini Int. Op., UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Service de Pharmacologie médicale [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Cardiologie [CHU Pitié-Salpêtrière], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and CHU Toulouse [Toulouse]
Subjects: Adult, Male, Acute coronary syndrome, medicine.medical_specialty, medicine.drug_class, Hemorrhage, Outcomes, 030204 cardiovascular system & hematology, Lower risk, Risk Assessment, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Risk Factors, Physiology (medical), Internal medicine, Cause of Death, Antithrombotic, Medicine, Humans, 030212 general & internal medicine, Prospective Studies, Registries, Practice Patterns, Physicians', Stroke, Aged, EORP-AF registry, Aged, 80 and over, Antithrombotic therapy, business.industry, Proportional hazards model, Atrial fibrillation, Vitamin K antagonist, Middle Aged, medicine.disease, Observational registries, Europe, Female, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Follow-Up Studies
Abstract: Aims In recent years, stroke prevention in patients with atrial fibrillation (AF) has radically changed, with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs). Contemporary European data on AF thromboprophylaxis are needed. Methods and results We report 1-year follow-up data from the EURObservational Research Programme in Atrial Fibrillation (EORP-AF) General Long-Term Registry. Outcomes were assessed according to antithrombotic therapy. At 1-year follow-up, 9663 (88.0%) patients had available data for analysis: 586 (6.1%) were not treated with any antithrombotic; 681 (7.0%) with antiplatelets only; 4066 (42.1%) with vitamin K antagonist (VKA) only; 3167 (32.8%) with NOACs only; and 1163 (12.0%) with antiplatelet and oral anticoagulant. At 1-year follow-up, there was a low rate of stroke (0.7%) and any thromboembolic event (TE) (1.2%), while haemorrhagic events occurred in 222 patients (2.3%). Cardiovascular (CV) death and all-cause death occurred in 3.9% and 5.2% of patients, respectively. Cumulative survival for all the three main outcomes considered was highest amongst patients treated only with NOACs (P Conclusion The 1-year follow-up of EORP-AF General Long-Term Registry reported a low occurrence of thromboembolic and haemorrhagic events, although mortality was high. Both VKA and NOACs were associated with a lower risk of all main adverse outcomes. All treatments were associated with a lower risk for CV death and all-cause death.
Published: 2019
Full Text: View/download PDF

44. The CDF Run IIb silicon detector

Author: Aoki, M., Bacchetta, N., Behari, S., Benjamin, D., Bisello, D., Bolla, G., Bortoletto, D., Burghard, A., Busetto, G., Cabrera, S., Canepa, A., Castro, A., Cardoso, G., Chertok, M., Ciobanu, C., Derylo, G., Fang, I., Flaugher, B., Freeman, J., Galtieri, L., Galyardt, J., Garcia-Sciveres, M., Giurgiu, G., Gorelov, I., Haber, C., Hara, K., Hoeferkamp, M., Holbrook, B., Hrycyk, M., Junk, T., Kim, S., Kobayashi, K., Krieger, B., Kruse, M., Lander, R., Lu, R.-S., Lukens, P., Malferrari, L., Manea, C., Margotti, A., Maksimovic, P., Merkel, P., Moccia, S., Nakano, I., Naoumov, D., Novak, J., Okusawa, T., Orlov, Y., Pancaldi, G., Pantano, D., Pavlicek, V., Pellett, D., Seidel, S., Semeria, F., Takei, Y., Tanaka, R., Wang, Z., Watje, P., Weber, M., Wester, W., Wilkes, T., Yamamoto, K., Yao, W., Zimmermann, S., Zucchelli, S., and Zucchini, A.
Published: 2004
Full Text: View/download PDF

45. Multiple meanings: shopping and the cultural politics of identity

Author: Jackson, P. and Holbrook, B.
Subjects: Consumption (Economics) -- Social aspects, Identity -- Social aspects, Shopping -- Social aspects, Environmental issues
Abstract: Consumption is an activity that drives society and reflects cultural attitudes of societal members. Shopping is a great social activity that requires skill; provides pleasure; is gender-based and allows people to be active. A focus group of shoppers from London, England, discuss the activity and how it personally relates to their identity and the overall cultural identity of a region. The methodology of the focus group is examined.
Published: 1995

46. Radio-assay of Titanium samples for the LUX Experiment

Author: Akerib, D. S., Bai, X., Bedikian, S., Bernard, E., Bernstein, A., Bradley, A., Cahn, S. B., Carmona-Benitez, M. C., Carr, D., Chapman, J. J., Chan, Y-D, Clark, K., Classen, T., Coffey, T., Dazeley, S., Viveiros, L., Dragowsky, M., Druszkiewicz, E., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gibson, K. R., Carter Hall, Hanhardt, M., Holbrook, B., Ihm, M., Jacobsen, R. G., Kastens, L., Kazkaz, K., Lander, R., Larsen, N., Lee, C., Leonard, D., Lesko, K., Lyashenko, A., Malling, D. C., Mannino, R., Mckinsey, D., Mei, D., Mock, J., Morii, M., Nelson, H., Nikkel, J. A., Pangilinan, M., Parker, P. D., Phelps, P., Shutt, T., Skulski, W., Sorensen, P., Spaans, J., Stiegler, T., Svoboda, R., Smith, A., Sweany, M., Szydagis, M., Thomson, J., Tripathi, M., Verbus, J. R., Walsh, N., Webb, R., White, J. T., Wlasenko, M., Wolfs, F. L. H., Woods, M., Uvarov, S., and Zhang, C.
Subjects: High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, hep-ex, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), physics.ins-det, High Energy Physics - Experiment
Abstract: We report on the screening of samples of titanium metal for their radio-purity. The screening process described in this work led to the selection of materials used in the construction of the cryostats for the Large Underground Xenon (LUX) dark matter experiment. Our measurements establish titanium as a highly desirable material for low background experiments searching for rare events. The sample with the lowest total long-lived activity was measured to contain, The LUX Collaboration
Published: 2018

47. After LUX: The LZ Program

Author: Malling, DC, Akerib, DS, Araujo, HM, Bai, X, Bedikian, S, Bernard, E, Bernstein, A, Bradley, A, Cahn, SB, Carmona-Benitez, MC, Carr, D, Chapman, JJ, Clark, K, Classen, T, Coffey, T, Curioni, A, Currie, A, Dazeley, S, Viveiros, LD, Dragowsky, M, Druszkiewicz, E, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gibson, KR, Hall, C, Hanhardt, M, Holbrook, B, Ihm, M, Jacobsen, RG, Kastens, L, Kazkaz, K, Lander, R, Larsen, N, Lee, C, Leonard, D, Lesko, K, Lindote, A, Lopes, MI, Lyashenko, A, Majewski, P, Mannino, R, McKinsey, DN, Mei, D-M, Mock, J, Morii, M, Murphy, ASJ, Nelson, H, Neves, F, Nikkel, JA, Pangilinan, M, Phelps, P, Reichhart, L, Shutt, T, Silva, C, Skulski, W, Solovov, V, Sorensen, P, Spaans, J, Stiegler, T, Sumner, TJ, Svoboda, R, Sweany, M, Szydagis, M, Thomson, J, Tripathi, M, Verbus, JR, Walsh, N, Webb, R, White, JT, Wlasenko, M, Wolfs, FLH, Woods, M, and Zhang, C
Subjects: astro-ph.CO, astro-ph.IM
Abstract: The LZ program consists of two stages of direct dark matter searches using liquid Xe detectors. The first stage will be a 1.5-3 tonne detector, while the last stage will be a 20 tonne detector. Both devices will benefit tremendously from research and development performed for the LUX experiment, a 350 kg liquid Xe dark matter detector currently operating at the Sanford Underground Laboratory. In particular, the technology used for cryogenics and electrical feedthroughs, circulation and purification, low-background materials and shielding techniques, electronics, calibrations, and automated control and recovery systems are all directly scalable from LUX to the LZ detectors. Extensive searches for potential background sources have been performed, with an emphasis on previously undiscovered background sources that may have a significant impact on tonne-scale detectors. The LZ detectors will probe spin-independent interaction cross sections as low as 5E-49 cm2 for 100 GeV WIMPs, which represents the ultimate limit for dark matter detection with liquid xenon technology.
Published: 2018

48. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score

Author: Carbone, M, Nardi, A, Flack, S, Carpino, G, Varvaropoulou, N, Gavrila, C, Spicer, A, Badrock, J, Bernuzzi, F, Cardinale, V, Ainsworth, H, Heneghan, M, Thorburn, D, Bathgate, A, Jones, R, Neuberger, J, Battezzati, P, Zuin, M, Taylor-Robinson, S, Donato, M, Kirby, J, Mitchell-Thain, R, Floreani, A, Sampaziotis, F, Muratori, L, Alvaro, D, Marzioni, M, Miele, L, Marra, F, Giannini, E, Gaudio, E, Ronca, V, Bonato, G, Cristoferi, L, Malinverno, F, Gerussi, A, Stocken, D, Cordell, H, Hirschfield, G, Alexander, G, Sandford, R, Jones, D, Invernizzi, P, Mells, G, Thomas, C, Rahman, M, Yapp, T, Lye Ch'ng, C, Harrison, M, Sturgess, R, Galaska, R, Healey, C, Whiteman, J, Czaijkowski, M, Gray, C, Gunasekera, A, Gyawli, P, Premchand, P, Mann, S, Elliott, K, Kapur, K, Watson, A, Foster, G, Trembling, P, Subhani, J, Harvey, R, Mccorry, R, Adgey, C, Hobson, L, Mulvaney-Jones, C, Evans, R, Mathialahan, T, Ramanaden, D, Gasem, J, Van Duyvenvoorde, G, Shorrock, C, Seward, K, Southern, P, Tibble, J, Penn, R, Gorard, D, Maiden, J, Damant, R, Palegwala, A, Jones, S, Dolwani, S, Prince, M, Silvestre, V, Foxton, M, Dungca, E, Mitchison, H, Wheatley, N, Gooding, I, Doyle, H, Karmo, M, Kent, M, Saksena, S, Braim, D, Patel, M, Lord, S, Ede, R, Paton, A, Austin, A, Lancaster, N, Sayer, J, Gibbins, A, Hogben, K, Hovell, C, Fisher, N, Carter, M, Koss, K, Musselwhite, J, Muscariu, F, Piotreowicz, A, Mckay, A, Grimley, C, Neal, D, Ting Tan, L, Lim, G, Brighton, J, Foale, C, Ala, A, Saeed, A, Flahive, K, Wood, G, Townshend, P, Ford, C, Brown, J, Kordula, J, Bowles, J, Wilkinson, M, Palmer, C, Ramage, J, Gordon, H, Featherstone, J, Ridpath, J, Ngatchu, T, Levi, S, Shaukat, S, Sadeghian, J, Shidrawi, R, Williams, B, Abouda, G, Duggan, C, Hynes, A, Narain, M, Rees, I, Salam, I, Crossey, M, Brown, A, Macnicol, C, Williams, S, Wilhelmsen, E, Banim, P, Raymode, P, Chilton, A, Das, D, Lee, H, Curtis, H, Gess, M, Durant, E, Drake, I, Bishop, R, Davies, M, Aldersley, M, Ncube, N, Mcnair, A, Srirajaskanthan, R, Sen, S, Casey, R, Bird, G, Mendall, M, Cowley, C, Barnardo, A, Kitchen, P, Yoong, K, Amore, K, Sirdefield, D, Orpe, J, Mathew, R, Macfaul, G, Wrigth, A, Shah, A, Evans, C, Keggans, J, Bird, B, Baxter, G, Saha, S, Pollock, K, Hughes, M, Bramley, P, Grieve, E, Young, K, Fraser, A, Mukhopadhya, A, Ocker, K, Mills, P, Hines, F, Shallcross, C, Wilkins, J, Grellier, L, Campbell, S, Martin, K, Innes, C, Shepherd, A, Rushbrook, S, Valliani, T, Przemioslo, R, Fairlamb, H, Macdonald, C, Eastick, A, Metcalf, J, Tanqueray, E, Shmueli, U, Holbrook, B, Davis, A, Browning, J, Naqvi, A, Walker, K, Lee, T, Verheyden, J, Slininger, S, Ryder, S, Chapman, R, Collier, J, O'Donnell, D, Stafford, L, Williamson, K, Kent, L, Klass, H, Ninkovic, M, March, L, Cramp, M, Simpson, D, Dickson, C, Sharer, N, Hayes, M, Goggin, P, Quinne, M, Pearson, S, Hoeroldt, B, Jones, L, Wright, A, Booth, J, Loftus, A, Lipscomb, G, Dewhurst, H, Gunter, E, Williams, E, Fouracres, A, Farrington, L, Graves, L, Hussaini, H, Stableforth, B, Marriott, S, Ayres, R, Leoni, M, Burroughs, A, Marshall, E, Tyrer, D, Lombard, M, Patanwala, I, Dali-Kemmery, L, Lambourne, V, Maltby, J, Vyas, S, Colley, J, Shinder, B, Singhal, S, Jones, J, Mills, M, Gleeson, D, Carnahan, M, Butterworth, J, Boulton, K, Taylor, N, George, K, Harding, T, Tregonning, J, Douglass, A, Brown, C, Clifford, G, Panter, S, Gocher, D, Shearman, J, Bray, G, Hamilton, M, Butcher, G, Forton, D, Mclindon, J, Curtis, J, Shewan, T, Cowan, M, Whatley, G, Nasseri, M, Grover, B, Sivaramakrishnan, N, Ducker, S, Houghton, K, Griffiths, L, Tripoli, S, Pitcher, M, Shpuza, E, White, N, Ghosh, D, Douds, A, Green, M, Brookes, M, Cumlat, L, Wong, V, Warner, K, Netherton, K, Mandal, A, Jain, S, Gupta, H, Sanghi, P, Pereira, S, Gunson, B, Lim, R, Gallagher, S, Clement, D, Brind, A, Watts, G, Mupudzi, M, Wright, M, Gitahi, J, Gordon, F, Unitt, E, Pateman, H, Batham, S, Delahooke, T, Grant, A, Conder, J, Higham, A, Cox, M, O'Donohoe, L, Currie, L, King, A, Oblak, M, Collins, C, Whalley, S, Quinn, M, Baird, Y, Amey, I, Fraser, J, Li, A, Cotterill, D, Bell, A, Singhal, A, Gee, I, Greer, S, Ang, Y, Ransford, R, Allison, J, Gotto, J, Dyer, S, Sweeting, H, Millson, C, Labbadia, G, Bragazzi, M, Andreone, P, Azzaroli, F, Galli, A, Tarocchi, M, Gasbarrini, A, Grieco, A, Marrone, G, Valenti, L, Maroni, L, Rigamonti, C, Picciotto, A, Carbone, Marco, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Bernuzzi, Francesca, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Thorburn, Douglas, Bathgate, Andrew, Jones, Rebecca, Neuberger, James M, Battezzati, Pier Maria, Zuin, Massimo, Taylor-Robinson, Simon, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Floreani, Annarosa, Sampaziotis, Fotios, Muratori, Luigi, Alvaro, Domenico, Marzioni, Marco, Miele, Luca, Marra, Fabio, Giannini, Edoardo, Gaudio, Eugenio, Ronca, Vincenzo, Bonato, Giulia, Cristoferi, Laura, Malinverno, Federica, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, Invernizzi, Pietro, Mells, George F, Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, I. M., Bishop, Rebecca, Davies, Mervyn, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Azzaroli, Francesco, Galli, Andrea, Tarocchi, Mirko, Gasbarrini, Antonio, GRIECO, ANTONIO, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Maroni, Luca, Rigamonti, Cristina, Picciotto, Antonino, Carbone, M, Nardi, A, Flack, S, Carpino, G, Varvaropoulou, N, Gavrila, C, Spicer, A, Badrock, J, Bernuzzi, F, Cardinale, V, Ainsworth, H, Heneghan, M, Thorburn, D, Bathgate, A, Jones, R, Neuberger, J, Battezzati, P, Zuin, M, Taylor-Robinson, S, Donato, M, Kirby, J, Mitchell-Thain, R, Floreani, A, Sampaziotis, F, Muratori, L, Alvaro, D, Marzioni, M, Miele, L, Marra, F, Giannini, E, Gaudio, E, Ronca, V, Bonato, G, Cristoferi, L, Malinverno, F, Gerussi, A, Stocken, D, Cordell, H, Hirschfield, G, Alexander, G, Sandford, R, Jones, D, Invernizzi, P, Mells, G, Thomas, C, Rahman, M, Yapp, T, Lye Ch'ng, C, Harrison, M, Sturgess, R, Galaska, R, Healey, C, Whiteman, J, Czaijkowski, M, Gray, C, Gunasekera, A, Gyawli, P, Premchand, P, Mann, S, Elliott, K, Kapur, K, Watson, A, Foster, G, Trembling, P, Subhani, J, Harvey, R, Mccorry, R, Adgey, C, Hobson, L, Mulvaney-Jones, C, Evans, R, Mathialahan, T, Ramanaden, D, Gasem, J, Van Duyvenvoorde, G, Shorrock, C, Seward, K, Southern, P, Tibble, J, Penn, R, Gorard, D, Maiden, J, Damant, R, Palegwala, A, Jones, S, Dolwani, S, Prince, M, Silvestre, V, Foxton, M, Dungca, E, Mitchison, H, Wheatley, N, Gooding, I, Doyle, H, Karmo, M, Kent, M, Saksena, S, Braim, D, Patel, M, Lord, S, Ede, R, Paton, A, Austin, A, Lancaster, N, Sayer, J, Gibbins, A, Hogben, K, Hovell, C, Fisher, N, Carter, M, Koss, K, Musselwhite, J, Muscariu, F, Piotreowicz, A, Mckay, A, Grimley, C, Neal, D, Ting Tan, L, Lim, G, Brighton, J, Foale, C, Ala, A, Saeed, A, Flahive, K, Wood, G, Townshend, P, Ford, C, Brown, J, Kordula, J, Bowles, J, Wilkinson, M, Palmer, C, Ramage, J, Gordon, H, Featherstone, J, Ridpath, J, Ngatchu, T, Levi, S, Shaukat, S, Sadeghian, J, Shidrawi, R, Williams, B, Abouda, G, Duggan, C, Hynes, A, Narain, M, Rees, I, Salam, I, Crossey, M, Brown, A, Macnicol, C, Williams, S, Wilhelmsen, E, Banim, P, Raymode, P, Chilton, A, Das, D, Lee, H, Curtis, H, Gess, M, Durant, E, Drake, I, Bishop, R, Davies, M, Aldersley, M, Ncube, N, Mcnair, A, Srirajaskanthan, R, Sen, S, Casey, R, Bird, G, Mendall, M, Cowley, C, Barnardo, A, Kitchen, P, Yoong, K, Amore, K, Sirdefield, D, Orpe, J, Mathew, R, Macfaul, G, Wrigth, A, Shah, A, Evans, C, Keggans, J, Bird, B, Baxter, G, Saha, S, Pollock, K, Hughes, M, Bramley, P, Grieve, E, Young, K, Fraser, A, Mukhopadhya, A, Ocker, K, Mills, P, Hines, F, Shallcross, C, Wilkins, J, Grellier, L, Campbell, S, Martin, K, Innes, C, Shepherd, A, Rushbrook, S, Valliani, T, Przemioslo, R, Fairlamb, H, Macdonald, C, Eastick, A, Metcalf, J, Tanqueray, E, Shmueli, U, Holbrook, B, Davis, A, Browning, J, Naqvi, A, Walker, K, Lee, T, Verheyden, J, Slininger, S, Ryder, S, Chapman, R, Collier, J, O'Donnell, D, Stafford, L, Williamson, K, Kent, L, Klass, H, Ninkovic, M, March, L, Cramp, M, Simpson, D, Dickson, C, Sharer, N, Hayes, M, Goggin, P, Quinne, M, Pearson, S, Hoeroldt, B, Jones, L, Wright, A, Booth, J, Loftus, A, Lipscomb, G, Dewhurst, H, Gunter, E, Williams, E, Fouracres, A, Farrington, L, Graves, L, Hussaini, H, Stableforth, B, Marriott, S, Ayres, R, Leoni, M, Burroughs, A, Marshall, E, Tyrer, D, Lombard, M, Patanwala, I, Dali-Kemmery, L, Lambourne, V, Maltby, J, Vyas, S, Colley, J, Shinder, B, Singhal, S, Jones, J, Mills, M, Gleeson, D, Carnahan, M, Butterworth, J, Boulton, K, Taylor, N, George, K, Harding, T, Tregonning, J, Douglass, A, Brown, C, Clifford, G, Panter, S, Gocher, D, Shearman, J, Bray, G, Hamilton, M, Butcher, G, Forton, D, Mclindon, J, Curtis, J, Shewan, T, Cowan, M, Whatley, G, Nasseri, M, Grover, B, Sivaramakrishnan, N, Ducker, S, Houghton, K, Griffiths, L, Tripoli, S, Pitcher, M, Shpuza, E, White, N, Ghosh, D, Douds, A, Green, M, Brookes, M, Cumlat, L, Wong, V, Warner, K, Netherton, K, Mandal, A, Jain, S, Gupta, H, Sanghi, P, Pereira, S, Gunson, B, Lim, R, Gallagher, S, Clement, D, Brind, A, Watts, G, Mupudzi, M, Wright, M, Gitahi, J, Gordon, F, Unitt, E, Pateman, H, Batham, S, Delahooke, T, Grant, A, Conder, J, Higham, A, Cox, M, O'Donohoe, L, Currie, L, King, A, Oblak, M, Collins, C, Whalley, S, Quinn, M, Baird, Y, Amey, I, Fraser, J, Li, A, Cotterill, D, Bell, A, Singhal, A, Gee, I, Greer, S, Ang, Y, Ransford, R, Allison, J, Gotto, J, Dyer, S, Sweeting, H, Millson, C, Labbadia, G, Bragazzi, M, Andreone, P, Azzaroli, F, Galli, A, Tarocchi, M, Gasbarrini, A, Grieco, A, Marrone, G, Valenti, L, Maroni, L, Rigamonti, C, Picciotto, A, Carbone, Marco, Nardi, Alessandra, Flack, Steve, Carpino, Guido, Varvaropoulou, Nikoletta, Gavrila, Caius, Spicer, Ann, Badrock, Jonathan, Bernuzzi, Francesca, Cardinale, Vincenzo, Ainsworth, Holly F, Heneghan, Michael A, Thorburn, Douglas, Bathgate, Andrew, Jones, Rebecca, Neuberger, James M, Battezzati, Pier Maria, Zuin, Massimo, Taylor-Robinson, Simon, Donato, Maria F, Kirby, John, Mitchell-Thain, Robert, Floreani, Annarosa, Sampaziotis, Fotios, Muratori, Luigi, Alvaro, Domenico, Marzioni, Marco, Miele, Luca, Marra, Fabio, Giannini, Edoardo, Gaudio, Eugenio, Ronca, Vincenzo, Bonato, Giulia, Cristoferi, Laura, Malinverno, Federica, Gerussi, Alessio, Stocken, Deborah D, Cordell, Heather J, Hirschfield, Gideon M, Alexander, Graeme J, Sandford, Richard N, Jones, David E, Invernizzi, Pietro, Mells, George F, Thomas, Caradog, Rahman, Meshbah, Yapp, Tom, Lye Ch'ng, Chin, Harrison, Melanie, Sturgess, Richard, Galaska, Roman, Healey, Chris, Whiteman, Jessica, Czaijkowski, Marek, Gray, Catherine, Gunasekera, Anton, Gyawli, Pranab, Premchand, Purushothaman, Mann, Steven, Elliott, Keith, Kapur, Kapil, Watson, Alan, Foster, Graham, Trembling, Paul, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Adgey, Carolyn, Hobson, Lucie, Mulvaney-Jones, Caroline, Evans, Richard, Mathialahan, Thiriloganathan, Ramanaden, David, Gasem, Jaber, Van Duyvenvoorde, Greta, Shorrock, Christopher, Seward, Katie, Southern, Paul, Tibble, Jeremy, Penn, Ruth, Gorard, David, Maiden, Jane, Damant, Rose, Palegwala, Altaf, Jones, Susan, Alexander, Graeme, Mells, George, Sandford, Richard, Dolwani, Sunil, Prince, Martin, Silvestre, Valeria, Foxton, Matthew, Dungca, Eleanor, Mitchison, Harriet, Wheatley, Natalie, Gooding, Ian, Doyle, Helen, Karmo, Mazn, Kent, Melanie, Saksena, Sushma, Braim, Delyth, Patel, Minesh, Lord, Susan, Ede, Roland, Paton, Alison, Austin, Andrew, Lancaster, Nicola, Sayer, Joanna, Gibbins, Andrew, Hogben, Karen, Hovell, Chris, Fisher, Neil, Carter, Martyn, Koss, Konrad, Musselwhite, Janine, Muscariu, Florin, Piotreowicz, Andrzej, McKay, Alexandra, Grimley, Charles, Neal, David, Ting Tan, Lai, Lim, Guan, Brighton, Jacqueline, Foale, Carole, Ala, Aftab, Saeed, Athar, Flahive, Kerry, Wood, Gordon, Townshend, Paula, Ford, Chris, Brown, Jonathan, Kordula, Jean, Bowles, Jane, Wilkinson, Mark, Palmer, Caroline, Ramage, John, Gordon, Harriet, Featherstone, James, Ridpath, Jo, Ngatchu, Theodore, Levi, Sass, Shaukat, Syed, Sadeghian, Joy, Shidrawi, Ray, Williams, Bronwen, Abouda, George, Jones, Sarah, Duggan, Claire, Hynes, Abigail, Narain, Mark, Rees, Ian, Salam, Imroz, Crossey, Mary, Brown, Ashley, MacNicol, Carolyn, Williams, Simon, Wilhelmsen, Elva, Banim, Paul, Raymode, Parizade, Chilton, Andrew, Das, Debasish, Lee, Hye-Jeong, Curtis, Howard, Heneghan, Michael, Gess, Markus, Durant, Emma, Drake, I. M., Bishop, Rebecca, Davies, Mervyn, Aldersley, Mark, Ncube, Noma, McNair, Alistair, Srirajaskanthan, Raj, Sen, Sambit, Casey, Rebecca, Bird, George, Mendall, Mike, Cowley, Caroline, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Amore, Kelly, Sirdefield, Dawn, Orpe, Jacky, Mathew, Ray, MacFaul, George, Wrigth, Aruna, Shah, Amir, Evans, Chris, Keggans, Janie, Bird, Bridget, Baxter, Gwen, Saha, Subrata, Pollock, Katharine, Hughes, Maggie, Bramley, Peter, Grieve, Emma, Young, Karin, Fraser, Andrew, Mukhopadhya, Ashis, Ocker, Kate, Mills, Peter, Hines, Francis, Shallcross, Chris, Wilkins, Joy, Grellier, Leonie, Campbell, Stewart, Martin, Kirsty, Innes, Caron, Shepherd, Alan, Rushbrook, Simon, Valliani, Talal, Przemioslo, Robert, Fairlamb, Helen, Macdonald, Chris, Eastick, Anne, Metcalf, Jane, Tanqueray, Elizabeth, Shmueli, Udi, Holbrook, Becky, Davis, Andrew, Browning, Julie, Naqvi, Asifabbas, Walker, Kirsten, Lee, Tom, Verheyden, Juliette, Slininger, Susan, Ryder, Stephen D, Chapman, Roger, Collier, Jane, O'Donnell, Denise, Stafford, Lizzie, Williamson, Kate, Kent, Linda, Klass, Howard, Ninkovic, Mary, March, Linda, Cramp, Matthew, Simpson, Diane, Dickson, Christine, Sharer, Nicholas, Hayes, Maria, Goggin, Patrick, Quinne, Mary, Pearson, Sallyanne, Hoeroldt, Barbara, Jones, Linda, Wright, Alice, Booth, Jonathan, Loftus, Alison, Lipscomb, George, Dewhurst, Hannah, Gunter, Emma, Williams, Earl, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Hussaini, Hyder, Stableforth, Bill, Marriott, Suzie, Ayres, Reuben, Leoni, Marina, Burroughs, Andrew, Marshall, Eileen, Tyrer, David, Martin, Kate, Lombard, Martin, Patanwala, Imran, Dali-Kemmery, Lola, Lambourne, Victoria, Maltby, Julia, Vyas, Samir, Colley, Julie, Shinder, Bal, Singhal, Saket, Jones, Jayne, Mills, Marisa, Gleeson, Dermot, Carnahan, Mandy, Butterworth, Jeff, Boulton, Kerenza, Taylor, Natalie, George, Keith, Harding, Tim, Tregonning, Julie, Douglass, Andrew, Brown, Carly, Clifford, Gayle, Panter, Simon, Gocher, Denise, Shearman, Jeremy, Bray, Gary, Hamilton, Maria, Butcher, Graham, Forton, Daniel, Mclindon, John, Curtis, Janette, Das, Debashis, Shewan, Tracey, Cowan, Matthew, Whatley, Gregory, Nasseri, Mariam, Grover, Bob, Sivaramakrishnan, Nurani, Ducker, Samantha, Houghton, Kathryn, Jones, David, Griffiths, Laura, Tripoli, Sherill, Pitcher, Maxton, Shpuza, Ervin, White, Nikki, Ghosh, Deb, Douds, Andrew, Green, Marie, Brookes, Matthew, Cumlat, Lourdes, Wong, Voi Shim, Warner, Karen, Netherton, Kimberley, Mandal, Adtya, Jain, Snjiv, Gupta, Hemant, Sanghi, Pradeep, Pereira, Steve, Neuberger, James, Gunson, Bridget, Hirschfield, Gideon, Lim, Reina Teegan, Gallagher, Susan, Clement, Darren, Brind, Alison, Watts, Gill, Mupudzi, Mcdonald, Wright, Mark, Gitahi, Jane, Gordon, Fiona, Gocher, Denis, Unitt, Esther, Pateman, Hilary, Batham, Sally, Delahooke, Toby, Grant, Allister, Conder, Jill, Higham, Andrew, Cox, Mark, O'Donohoe, Lynn, Currie, Lynn, King, Alistair, Oblak, Metod, Collins, Carole, Whalley, Simon, Quinn, Marie, Baird, Yolanda, Amey, Isobel, Fraser, Jocelyn, Li, Andy, Cotterill, Donna, Bell, Andrew, Singhal, Amit, Gee, Ian, Greer, Sandra, Ang, Yeng, Ransford, Rupert, Allison, Joanna, Gotto, James, Dyer, Simon, Sweeting, Helen, Millson, Charles, Labbadia, Giancarlo, Bragazzi, Maria Consiglia, Andreone, Pietro, Azzaroli, Francesco, Galli, Andrea, Tarocchi, Mirko, Gasbarrini, Antonio, GRIECO, ANTONIO, Marrone, Giuseppe, Donato, Maria Francesca, Valenti, Luca, Maroni, Luca, Rigamonti, Cristina, and Picciotto, Antonino
Abstract: Background: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters. Methods: We did logistic regression analysis of pretreatment variables in a discovery cohort of patients in the UK with primary biliary cholangitis to derive the best-fitting model of UDCA response, defined as alkaline phosphatase less than 1·67 times the upper limit of normal (ULN), measured after 12 months of treatment with UDCA. We validated the model in an external cohort of patients with primary biliary cholangitis and treated with UDCA in Italy. Additionally, we assessed correlations between model predictions and key histological features, such as biliary injury and fibrosis, on liver biopsy samples. Findings: 2703 participants diagnosed with primary biliary cholangitis between Jan 1, 1998, and May 31, 2015, were included in the UK-PBC cohort for derivation of the model. The following pretreatment parameters were associated with lower probability of UDCA response: higher alkaline phosphatase concentration (p<0·0001), higher total bilirubin concentration (p=0·0003), lower aminotransferase concentration (p=0·0012), younger age (p<0·0001), longer interval from diagnosis to the start of UDCA treatment (treatment time lag, p<0·0001), and worsening of alkaline phosphatase concentration from diagnosis (p<0·0001). Based on these variables, we derived a predictive score of UDCA response. In the external validation cohort, 460 patients diagnosed with primary biliary cholangitis were treated with UDCA, with follow-up data until May 31, 2016. In this validation cohort, the area under the re
Published: 2018

49. Results of radiation test of the cathode front-end board for CMS endcap muon chambers

Author: Breedon, R, Bylsma, B, Durkin, L.S, Gilmore, J, Gu, J, Hauser, J, Holbrook, B, Kim, C.L, Ling, T.Y, von der Mey, M, Murray, P, Rush, C.J, Santiard, J.C, and Tripathi, M
Published: 2001
Full Text: View/download PDF

50. LUX-ZEPLIN (LZ) Technical Design Report

Author: Mount, BJ, Hans, S, Rosero, R, Yeh, M, Chan, C, Gaitskell, RJ, Huang, DQ, Makkinje, J, Malling, DC, Pangilinan, M, Rhyne, CA, Taylor, WC, Verbus, JR, Kim, YD, Lee, HS, Lee, J, Leonard, DS, Li, J, Belle, J, Cottle, A, Lippincott, WH, Markley, DJ, Martin, TJ, Sarychev, M, Tope, TE, Utes, M, Wang, R, Young, I, Araújo, HM, Bailey, AJ, Bauer, D, Colling, D, Currie, A, Fayer, S, Froborg, F, Greenwood, S, Jones, WG, Kasey, V, Khaleeq, M, Olcina, I, Paredes, BL, Richards, A, Sumner, TJ, Tomás, A, Vacheret, A, Brás, P, Lindote, A, Lopes, MI, Neves, F, Rodrigues, JP, Silva, C, Solovov, VN, Barry, MJ, Cole, A, Dobi, A, Edwards, WR, Faham, CH, Fiorucci, S, Gantos, NJ, Gehman, VM, Gilchriese, MGD, Hanzel, K, Hoff, MD, Kamdin, K, Lesko, KT, McConnell, CT, O'Sullivan, K, Oliver-Mallory, KC, Patton, SJ, Saba, JS, Sorensen, P, Thomas, KJ, Tull, CE, Waldron, WL, Witherell, MS, Bernstein, A, Kazkaz, K, Xu, J, Akimov, DY, Bolozdynya, AI, Khromov, AV, Konovalov, AM, Kumpan, AV, Sosnovtsev, VV, Dahl, CE, Temples, D, Carmona-Benitez, MC, Viveiros, LD, Akerib, DS, Auyeung, H, Biesiadzinski, TP, Breidenbach, M, Bramante, R, Conley, R, Craddock, WW, Fan, A, Hau, A, Ignarra, CM, Ji, W, Krebs, HJ, Linehan, R, Lee, C, Luitz, S, Mizrachi, E, Monzani, ME, O'Neill, FG, Pierson, S, Racine, M, Ratcliff, BN, Shutt, GW, Shutt, TA, Skarpaas, K, Stifter, K, To, WH, Va'vra, J, Whitis, TJ, Wisniewski, WJ, Bai, X, Bunker, R, Coughlen, R, Hjemfelt, C, Leonard, R, Miller, EH, Morrison, E, Reichenbacher, J, Schnee, RW, Stark, MR, Sundarnath, K, Tiedt, DR, Timalsina, M, Bauer, P, Carlson, B, Horn, M, Johnson, M, Keefner, J, Maupin, C, Taylor, DJ, Balashov, S, Ford, P, Francis, V, Holtom, E, Khazov, A, Kaboth, A, Majewski, P, Nikkel, JA, O'Dell, J, Preece, RM, Grinten, MGDVD, Worm, SD, Mannino, RL, Stiegler, TM, Terman, PA, Webb, RC, Levy, C, Mock, J, Szydagis, M, Busenitz, JK, Elnimr, M, Hor, JY-K, Meng, Y, Piepke, A, Stancu, I, Kreczko, L, Krikler, B, Penning, B, Bernard, EP, Jacobsen, RG, McKinsey, DN, Watson, R, Cutter, JE, El-Jurf, S, Gerhard, RM, Hemer, D, Hillbrand, S, Holbrook, B, Lenardo, BG, Manalaysay, AG, Morad, JA, Stephenson, S, Thomson, JA, Tripathi, M, Uvarov, S, Haselschwardt, SJ, Kyre, S, Nehrkorn, C, Nelson, HN, Solmaz, M, White, DT, Cascella, M, Dobson, JEY, Ghag, C, Liu, X, Manenti, L, Reichhart, L, Shaw, S, Utku, U, Beltrame, P, Davison, TJR, Marzioni, MF, Murphy, ASJ, Nilima, A, Boxer, B, Burdin, S, Greenall, A, Powell, S, Rose, HJ, Sutcliffe, P, Balajthy, J, Edberg, TK, Hall, CR, Silk, JS, Hertel, S, Akerlof, CW, Arthurs, M, Lorenzon, W, Pushkin, K, Schubnell, M, Boast, KE, Carels, C, Fruth, T, Kraus, H, Liao, F-T, Lin, J, Scovell, PR, Druszkiewicz, E, Khaitan, D, Koyuncu, M, Skulski, W, Wolfs, FLH, Yin, J, Korolkova, EV, Kudryavtsev, VA, Rossiter, P, Woodward, D, Chiller, AA, Chiller, C, Mei, D-M, Wang, L, Wei, W-Z, While, M, Zhang, C, Alsum, SK, Benson, T, Carlsmith, DL, Cherwinka, JJ, Dasu, S, Gregerson, G, Gomber, B, Pagac, A, Palladino, KJ, Vuosalo, CO, Xiao, Q, Buckley, JH, Bugaev, VV, Olevitch, MA, Boulton, EM, Emmet, WT, Hurteau, TW, Larsen, NA, Pease, EK, Tennyson, BP, and Tvrznikova, L
Subjects: High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Physics - Experiment
Abstract: In this Technical Design Report (TDR) we describe the LZ detector to be built at the Sanford Underground Research Facility (SURF). The LZ dark matter experiment is designed to achieve sensitivity to a WIMP-nucleon spin-independent cross section of three times ten to the negative forty-eighth square centimeters., 392 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Numbers Two and Three (CD-2 and CD-3) management processes. Report also available by chapter at this URL
Published: 2017

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

234 results on '"Holbrook, B"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources