Author: "Holash, Jocelyn" - Searchworks@Jio Institute Digital Library Search Results

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171 results on '"Holash, Jocelyn"'

1. Haploinsufficiency of Delta-Like 4 Ligand Results in Embryonic Lethality Due to Major Defects in Arterial and Vascular Development

Author: Gale, Nicholas W., Dominguez, Melissa G., Noguera, Irene, Pan, Li, Hughes, Virginia, Valenzuela, David M., Murphy, Andrew J., Adams, Niels C., Lin, Hsin Chieh, Holash, Jocelyn, Thurston, Gavin, and Yancopoulos, George D.
Published: 2004

2. The Shc Adaptor Protein Is Critical for VEGF Induction by Met/HGF and ErbB2 Receptors and for Early Onset of Tumor Angiogenesis

Author: Saucier, Caroline, Khoury, Hanane, Lai, Ka-Man Venus, Peschard, Pascal, Dankort, David, Naujokas, Monica A., Holash, Jocelyn, Yancopoulos, George D., Muller, William J., Pawson, Tony, and Park, Morag
Published: 2004

3. Regression of Established Tumors and Metastases by Potent Vascular Endothelial Growth Factor Blockade

Author: Huang, Jianzhong, Frischer, Jason S., Serur, Anna, Kadenhe, Angela, Yokoi, Akiko, McCrudden, Kimberly W., New, Tamara, O'Toole, Kathleen, Zabski, Stephanie, Rudge, John S., Holash, Jocelyn, Yancopoulos, George D., Yamashiro, Darrell J., and Kandel, Jessica J.
Published: 2003

4. Potent VEGF Blockade Causes Regression of Coopted Vessels in a Model of Neuroblastoma

Author: Kim, Eugene S., Serur, Anna, Huang, Jianzhong, Manley, Christina A., McCrudden, Kimberly W., Frischer, Jason S., Soffer, Samuel Z., Ring, Laurence, New, Tamara, Zabski, Stephanie, Rudge, John S., Holash, Jocelyn, Yancopoulos, George D., Kandel, Jessica J., and Yamashiro, Darrell J.
Published: 2002

5. VEGF-Trap: A VEGF Blocker with Potent Antitumor Effects

Author: Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, Boland, Patricia, Leidich, Ray, Hylton, Donna, Burova, Elena, Ioffe, Ella, Huang, Tammy, Radziejewski, Czeslaw, Bailey, Kevin, Fandl, James P., Daly, Tom, Wiegand, Stanley J., Yancopoulos, George D., and Rudge, John S.
Published: 2002

6. Excessive Tumor-Elaborated VEGF and Its Neutralization Define a Lethal Paraneoplastic Syndrome

Author: Wong, Alex K., Alfert, Myra, Castrillon, Diego H., Shen, Qiong, Holash, Jocelyn, Yancopoulos, George D., and Chin, Lynda
Published: 2001

7. Supplemental Table 2 from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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8. Supplemental Figures 1-5 from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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9. Data from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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10. Material and Methods from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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11. Supplemental Table 1 from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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12. Supplementary Figures S1-S6 from Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation

Author: Kadenhe-Chiweshe, Angela, primary, Papa, Joey, primary, McCrudden, Kimberly W., primary, Frischer, Jason, primary, Bae, Jae-O, primary, Huang, Jianzhong, primary, Fisher, Jason, primary, Lefkowitch, Jay H., primary, Feirt, Nikki, primary, Rudge, John, primary, Holash, Jocelyn, primary, Yancopoulos, George D., primary, Kandel, Jessica J., primary, and Yamashiro, Darrell J., primary
Published: 2023
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13. Supplementary Figure S5 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., primary, Karim, Christopher, primary, Embry, Millicent G., primary, Ghoddusi, Majid, primary, Holash, Jocelyn, primary, Fanidi, Abdallah, primary, Abrams, Tinya J., primary, and Abraham, Judith A., primary
Published: 2023
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14. Supplemental Figure legends from A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, primary, Tang, Yan, primary, Feng, Jiajia, primary, Barsanti, Paul, primary, Pan, Yue, primary, Ghoddusi, Majid, primary, Zhang, Wei, primary, Thomas, George, primary, Holash, Jocelyn, primary, Lees, Emma, primary, and Taricani, Lorena, primary
Published: 2023
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15. Supplementary Figure Legends from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., primary, Karim, Christopher, primary, Embry, Millicent G., primary, Ghoddusi, Majid, primary, Holash, Jocelyn, primary, Fanidi, Abdallah, primary, Abrams, Tinya J., primary, and Abraham, Judith A., primary
Published: 2023
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16. Supplementary Methods from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., primary, Karim, Christopher, primary, Embry, Millicent G., primary, Ghoddusi, Majid, primary, Holash, Jocelyn, primary, Fanidi, Abdallah, primary, Abrams, Tinya J., primary, and Abraham, Judith A., primary
Published: 2023
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17. Supplementary Table 1 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., primary, Karim, Christopher, primary, Embry, Millicent G., primary, Ghoddusi, Majid, primary, Holash, Jocelyn, primary, Fanidi, Abdallah, primary, Abrams, Tinya J., primary, and Abraham, Judith A., primary
Published: 2023
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18. Data from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., primary, Karim, Christopher, primary, Embry, Millicent G., primary, Ghoddusi, Majid, primary, Holash, Jocelyn, primary, Fanidi, Abdallah, primary, Abrams, Tinya J., primary, and Abraham, Judith A., primary
Published: 2023
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19. Developmental Expression and Distinctive Tyrosine Phosphorylation of the Eph-Related Receptor Tyrosine Kinase Cek9

Author: Soans, Chandrasen, Holash, Jocelyn A., Pavlova, Yelena, and Pasquale, Elena B.
Published: 1996

20. Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Author: Garcia, Pablo D., primary, Langowski, John L., primary, Wang, Yingyun, primary, Chen, Min, primary, Castillo, Joseph, primary, Fanton, Christie, primary, Ison, Marjorie, primary, Zavorotinskaya, Tatiana, primary, Dai, Yumin, primary, Lu, Jing, primary, Niu, Xiao-Hong, primary, Basham, Stephen, primary, Chan, Julie, primary, Yu, Jianjun, primary, Doyle, Michael, primary, Feucht, Paul, primary, Warne, Robert, primary, Narberes, Jamie, primary, Tsang, Tiffany, primary, Fritsch, Christine, primary, Kauffmann, Audrey, primary, Pfister, Estelle, primary, Drueckes, Peter, primary, Trappe, Joerg, primary, Wilson, Christopher, primary, Han, Wooseok, primary, Lan, Jiong, primary, Nishiguchi, Gisele, primary, Lindvall, Mika, primary, Bellamacina, Cornelia, primary, Aycinena, J. Alex, primary, Zang, Richard, primary, Holash, Jocelyn, primary, and Burger, Matthew T., primary
Published: 2023
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21. Supplemental Figures and Table from Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors

Author: Abrams, Tinya, primary, Connor, Anu, primary, Fanton, Christie, primary, Cohen, Steven B., primary, Huber, Thomas, primary, Miller, Kathy, primary, Hong, E. Erica, primary, Niu, Xiaohong, primary, Kline, Janine, primary, Ison-Dugenny, Marjorie, primary, Harris, Sarah, primary, Walker, Dana, primary, Krauser, Klaus, primary, Galimi, Francesco, primary, Wang, Zhen, primary, Ghoddusi, Majid, primary, Mansfield, Keith, primary, Lee-Hoeflich, Si Tuen, primary, Holash, Jocelyn, primary, Pryer, Nancy, primary, Kluwe, William, primary, Ettenberg, Seth A., primary, Sellers, William R., primary, Lees, Emma, primary, Kwon, Paul, primary, Abraham, Judith A., primary, and Schleyer, Siew C., primary
Published: 2023
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22. VEGF Trap Complex Formation Measures Production Rates of VEGF, Providing a Biomarker for Predicting Efficacious Angiogenic Blockade

Author: Rudge, John S., Holash, Jocelyn, Hylton, Donna, Russell, Michelle, Jiang, Shelly, Leidich, Raymond, Papadopoulos, Nicholas, Pyles, Erica A., Torri, Al, Wiegand, Stanley J., Thurston, Gavin, Stahl, Neil, and Yancopoulos, George D.
Published: 2007
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23. Barrier Properties of Testis Microvessels

Author: Holash, Jocelyn A., Harik, Sami I., Perry, George, and Stewart, Patricia A.
Published: 1993

24. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells

Author: Luqman, Mohammad, Klabunde, Sha, Lin, Karen, Georgakis, Georgios V., Cherukuri, Anu, Holash, Jocelyn, Goldbeck, Cheryl, Xu, Xiaomei, Kadel, Edward E., III, Lee, Sang Hoon, Aukerman, Sharon Lea, Jallal, Bahija, Aziz, Natasha, Weng, Wen-Kai, Wierda, William, O'Brien, Susan, and Younes, Anas
Published: 2008
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25. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents

Author: Holash, Jocelyn, Thurston, Gavin, Rudge, John S., Yancopoulos, George D., Adjei, Alex A., Bergers, Gabriele, Pytowski, Bronislaw, Pegram, Mark, and Gordon, Michael S.
Published: 2006
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26. Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis

Author: Zagzag, David, Amirnovin, Ramin, Greco, M Alba, Yee, Herman, Holash, Jocelyn, Wiegand, Stanley J, Zabski, Stephanie, Yancopoulos, George D, and Grumet, Martin
Published: 2000
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27. Vascular-specific growth factors and blood vessel formation

Author: Yancopoulos, George D., Davis, Samuel, Gale, Nicholas W., Rudge, John S., Wiegand, Stanley J., and Holash, Jocelyn
Subjects: Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): George D. Yancopoulos [1]; Samuel Davis [1]; Nicholas W. Gale [1]; John S. Rudge [1]; Stanley J. Wiegand [1]; Jocelyn Holash [1] Until recently, vascular endothelial growth factor (VEGF) [...]
Published: 2000
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28. Angiopoietin-1 protects the adult vasculature against plasma leakage

Author: Thurston, Gavin, Rudge, John S., Ioffe, Ella, Zhou, Hao, Ross, Leorah, Croll, Susan D., Glazer, Nicole, Holash, Jocelyn, McDonald, Donald M., and Yancopoulos, George D.
Abstract: Pathological increases in vascular leakage lead to edema and swelling, causing serious problems in brain tumors, in diabetic retinopathy, after strokes, during sepsis and also in inflammatory conditions such as rheumatoid arthritis and asthma. Although many agents and disease processes increase vascular leakage, no known agent specifically makes vessels resistant to leaking. Vascular endothelial growth factor (VEGF) and the angiopoietins function together during vascular development, with VEGF acting early during vessel formation, and angiopoietin-1 acting later during vessel remodeling, maturation and stabilization. Although VEGF was initially called vascular permeability factor, there has been less focus on its permeability actions and more effort devoted to its involvement in vessel growth and applications in ischemia and cancer. Recent transgenic approaches have confirmed the profound permeability effects of VEGF (refs. 12-14), and have shown that transgenic angiopoietin-1 acts reciprocally as an anti-permeability factor when provided chronically during vessel formation, although it also profoundly affects vascular morphology when thus delivered. To be useful clinically, angiopoietin-1 would have to inhibit leakage when acutely administered to adult vessels, and this action would have to be uncoupled from its profound angiogenic capabilities. Here we show that acute administration of angiopoietin-1 does indeed protect adult vasculature from leaking, countering the potentially lethal actions of VEGF and inflammatory agents., Author(s): Gavin Thurston (corresponding author) [1]; John S. Rudge [2]; Ella Ioffe [2]; Hao Zhou [2]; Leorah Ross [2]; Susan D. Croll [2]; Nicole Glazer [1]; Jocelyn Holash [2]; Donald [...]
Published: 2000
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29. Essential role for oncogenic Ras in tumour maintenance

Author: Chin, Lynda, Tam, Alice, Pomerantz, Jason, Wong, Michelle, Holash, Jocelyn, Bardeesy, Nabeel, Shen, Qiong, O'Hagan, Ronan, Pantginis, Joe, Zhou, Hao, Horner, James W. II, Cordon-Cardo, Carlos, Yancopoulos, George D., and DePinho, Ronald
Subjects: Tumors -- Research, Oncogenes -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Melanoma genesis and maintenance are shown to be strictly dependent on expression of H-RasV12G in a doxycycline-inducible H-RasV12G mouse melanoma model, null for the INK4a tumor suppressor. A failure of persistent endogenous and enforced vascular endothelial growth factor (VEGF) in sustaining tumor viability, suggests that activated Ras tumor-maintaining action extends beyond regulation of VEGF.
Published: 1999

30. Contributors

Author: Abrams, John M., primary, Adelman, John P., additional, Alcorn, Joseph L., additional, Alessi, Dario R., additional, Alexov, Emil, additional, Alford, Simon, additional, Alitalo, Kari, additional, Allison, James P., additional, Almo, Steven C., additional, Alory, Christelle, additional, Al-Shamkhani, Aymen, additional, Amundson, Sally A., additional, Anderson, Carl W., additional, Andersen, Jannik N., additional, Angel, Peter, additional, Appella, Ettore, additional, Arendshorst, William J., additional, Arkinstall, Steve, additional, Audhya, Anjon, additional, Avruch, Joseph, additional, Bader, Gary D., additional, Bagala, Cinzia, additional, Balch, William E., additional, Balsinde, Jesus, additional, Banerjee, Utpal, additional, Barford, David, additional, Bar-Sagi, Dafna, additional, Bartlett, Perry F., additional, Bastiaens, Philippe I.H., additional, Battelli, Chiara, additional, Baudhuin, Linnea M., additional, Beavil, Andrew J., additional, Beavil, Rebecca L., additional, Beavo, Joseph A., additional, Bello-Reuss, Elsa, additional, Bellum, Stephen, additional, Belmonte, Juan Carlos Izpisúa, additional, Bennett, Craig B., additional, Benovic, Jeffrey L., additional, Berridge, Michael J., additional, Beuning, Penny J., additional, Bhandari, Rashna, additional, Bhattacharya, Ananya, additional, Biel, Martin, additional, Bielinski, Vincent A., additional, Bilak, Hana, additional, Birnbaumer, Lutz, additional, Birrell, Geoff, additional, Bishop, Gail A., additional, Blackmer, Trillium, additional, Blackshear, Perry J., additional, Blattner, Christine, additional, Blaustein, Mordecai P., additional, Bokoch, Gary M., additional, Bonewald, Lynda F., additional, Bonomi, Marco, additional, Booden, Michelle A., additional, Boone, Charles, additional, Bootman, Martin D., additional, Bos, Johannes L., additional, Bradbury, Jane M., additional, Bradshaw, Ralph A., additional, Bresnick, Anne R., additional, Brevnova, Lena, additional, Brinkworth, Ross I., additional, Brown, Michael S., additional, Brown, Steven A., additional, Brunet, Anne, additional, Bucki, Robert, additional, Burgoyne, Robert D., additional, Buss, Janice E., additional, Butow, Ronald A., additional, Capdevila, Javier, additional, Carafoli, Ernesto, additional, Carlson, Cathrine R., additional, Carpenter, Graham, additional, Carrillo, Juan J., additional, Casey, Patrick J., additional, Catterall, William A., additional, Cerione, Richard A., additional, Cesareni, Gianni, additional, Chan, Andrew C., additional, Chang, Geoffrey, additional, Chao, Moses V., additional, Charbonneau, Harry, additional, Chen, Philip, additional, Cheng, Alan, additional, Chiu, Chris, additional, Chow, Dar-chone, additional, Chrisman, Ted D., additional, Christensen, Anne Elisabeth, additional, Chung, Jee Y., additional, Churchill, Grant C., additional, Ciechanover, Aaron, additional, Cingolani, Gino, additional, Claeysen, Sylvie, additional, Closset, Jean, additional, Cockcroft, Shamshad, additional, Cohen, Patricia T.W., additional, Cohen, Philip, additional, Colbran, Roger J., additional, Comstock, Clay E.S., additional, Conti, Marco, additional, Corbin, Jackie D., additional, Corda, Daniela, additional, Costagliola, Sabine, additional, Cote, Rick H., additional, Coughlin, Shaun R., additional, Cowart, L. Ashley, additional, Cox, Adrienne D., additional, Cragg, Mark S., additional, Crespo, José L., additional, Crosio, Claudia, additional, Daly, Christopher, additional, Damak, Sami, additional, Dasso, Mary, additional, David, Michael, additional, Davis, Anthony J., additional, Davis, Roger J., additional, Day, Richard N., additional, Degerman, Eva, additional, DeLano, Warren L., additional, Dell'Acqua, Mark L., additional, Délot, Emmanuèle, additional, Demple, Bruce, additional, Dennis, Edward A., additional, Denu, John M., additional, DePaoli-Roach, Anna A., additional, Der, Channing J., additional, de Rooij, Johan, additional, de Sauvage, Frederic, additional, Devreotes, Peter N., additional, Dewaste, Valérie, additional, Dickson, Robert B., additional, Diebold, Becky A., additional, Fiori, Pier Paolo Di, additional, Girolamo, Maria Di, additional, Diplexcito, Julie, additional, Dixon, Jack E., additional, Doms, Robert W., additional, Donoghue, Daniel J., additional, Doolittle, Russell F., additional, Døskeland, Stein Ove, additional, Dostmann, Wolfgang R.G., additional, Dreyer, Matthias K., additional, Du, Guo Guang, additional, Du, Keyong, additional, Duchen, Michael R., additional, Dunphy, William G., additional, Durgan, Joanne, additional, Dustin, Michael L., additional, Edwards, Peter A., additional, Egen, Jackson G., additional, Eiden, Lee E., additional, Elion, Elaine A., additional, Emr, Scott, additional, Engelhardt, Othmar G., additional, Erneux, Christophe, additional, Espenshade, Peter J., additional, Esplin, Edward D., additional, Evers, B. Mark, additional, Eyles, Joanne L., additional, Fame, Sheelagh, additional, Farquhar, Marilyn, additional, Feil, Robert, additional, Feng, Gui-Jie, additional, Fields, Stanley, additional, Fiordalisi, James J., additional, Firtel, Richard A., additional, Fitzgerald, Garret A., additional, Flint, Andrew, additional, Foiani, Marco, additional, Forman, Barry Marc, additional, Fornace, Albert J., additional, Francis, Sharron H., additional, Fritz, Günter, additional, Fruman, David A., additional, Galione, Antony, additional, Gandhi, Chris S., additional, Garbers, David L., additional, Garcia, K. Christopher, additional, Geiger, Benjamin, additional, Gerace, Larry, additional, Gerstner, Andrea, additional, Giaccia, Amato J., additional, Giannattasio, Michele, additional, Giguère, Vincent, additional, Glass, Christopher K., additional, Glennie, Martin J., additional, Glick, Jennifer L., additional, Goldstein, Joseph L., additional, Gopal, Venkatesh, additional, Gorospe, Myriam, additional, Govaerts, Cedric, additional, Graves, Paul R., additional, Gray, Patrick W., additional, Graziani, Irene, additional, Green, Douglas R., additional, Greenberg, Michael E., additional, Greenwald, Iva, additional, Gu, Haihua, additional, Gueven, Nuri, additional, Gutkind, J. Silvio, additional, Haeggström, Jesper Z., additional, Hall, Alan, additional, Hall, Michael N., additional, Haller, Otto, additional, Hamm, Heidi E., additional, Hannun, Yusef A., additional, Hansen, Carl A., additional, Harden, T. Kendall, additional, Hardie, D. Grahame, additional, Hasegawa, Kiminori, additional, Hawkins, Phillip T., additional, Haystead, Timothy A.J., additional, He, Xiao-lin, additional, Heizmann, Claus W., additional, Heldin, Carl-Henrik, additional, Hermiston, Michelle L., additional, Herrlich, Peter, additional, Hewat, Elizabeth A., additional, Hille, Bertil, additional, Hilton, Douglas J., additional, Hinchliffe, K.A., additional, Ho, Steffan N., additional, Ho, Su-Chin, additional, Hochstrasser, Mark, additional, Hofmann, Franz, additional, Hogue, Christopher W., additional, Hol, Wim G.J., additional, Holash, Jocelyn, additional, Holmgren, Robert A., additional, Honig, Barry, additional, Hostager, Bruce S., additional, Hubbard, Stevan R., additional, Huber, Michael, additional, Hunter, Tony, additional, Huttenlocher, Anna, additional, Hymowitz, Sarah G., additional, Ihle, James N., additional, Imler, Jean-Luc, additional, Irvine, R.F., additional, Isacoff, Ehud Y., additional, Iturrioz, Xavier, additional, Iversen, Lars F., additional, Iyengar, Ravi, additional, Jackson, Stephen P., additional, Jan, Lily Yeh, additional, Janiak-Spens, Fabiola, additional, Janmey, Paul A., additional, Jansen, Peter Gildsig, additional, Jarriault, Sophie, additional, Javitch, Jonathan A., additional, Jensen, Elwood V., additional, Jepsen, Kristen, additional, Jones, E. Yvonne, additional, Jones, Katherine A., additional, Jordan, J. Dedrick, additional, Joseph, Jomon, additional, Justement, Louis B., additional, Kafri, Yariv, additional, Kahn, Richard A., additional, Kang, Shin W., additional, Karlin, Arthur, additional, Kast-Woelbern, Heidi R., additional, Kaufman, Randal J., additional, Kazlauskas, Andrius, additional, Keen, James H., additional, Kemler, Rolf, additional, Kemp, Bruce E., additional, Kennedy, Mary B., additional, Kennedy, Matthew A., additional, Kikkawa, Ushio, additional, Kim, Albert H., additional, Kim, Soo-A, additional, Kim, Sung-Hou, additional, Kim, Youngjoo, additional, King-Jones, Kirst, additional, Kintner, Chris, additional, Kivimäe, Saul, additional, Klee, Claude B., additional, Klein, Rüdiger, additional, Kleppisch, Thomas, additional, Kliewer, Steven A., additional, Klinghoffer, Richard A., additional, Knoblich, Juergen A., additional, Kobe, Bostjan, additional, Kochs, George, additional, Kong-Beltran, Monica, additional, König, Rolf, additional, Koong, Albert C., additional, Korc, Murray, additional, Kornitzer, Daniel, additional, Kossiakoff, Anthony A., additional, Kotera, Jun, additional, Kovalenko, M.V., additional, Kozasa, Tohru, additional, Kozlov, Sergei, additional, Kozminski, Keith G., additional, Krugmann, Sonja, additional, Kuriyan, John, additional, Kurokawa, Riki, additional, Kwong, Peter D., additional, Lai, Wi S., additional, Lamar, Elise, additional, Lambert, Millard H., additional, Lambright, David G., additional, Lancet, Doron, additional, Landry, Reiko, additional, Langdon, Wallace Y., additional, Langeberg, Lorene K., additional, Lasko, Paul, additional, Latham, Vaughn, additional, Lavin, Martin F., additional, Lease, Kevin A., additional, Leffler, Hakon, additional, Lemmon, Mark A., additional, Leonard, Ann E., additional, Levitzki, Alexander, additional, Liao, Hong-Jun, additional, Liaw, Lucy, additional, Liberi, Giordano, additional, Lickert, Heiko, additional, Liddington, Robert C., additional, Lincoln, Thomas M., additional, Linder, Jürgen U., additional, Linder, Maurine E., additional, Liu, Hui, additional, Liu, Zhengchang, additional, Lohela, Marja K., additional, Louie, Sarah H., additional, Luttrell, Deirdre K., additional, Luttrell, Louis M., additional, Lyons, Karen M., additional, Macaulay, S. Lance, additional, Maceyka, Michael, additional, Maciag, Thomas, additional, Macian, Fernando, additional, MacKintosh, Carol, additional, MacLennan, David H., additional, Mahmood, Nadir A., additional, Malbon, Craig C., additional, Malik, Sohail, additional, Man, Orna, additional, Manahan, Carol L., additional, Mandinova, Anna, additional, Manganiello, Vincent C., additional, Manley, James L., additional, Mann, Matthias, additional, Manning, Gerald, additional, Manser, Ed, additional, Margeta-Mitrovic, Marta, additional, Margolskee, Robert F., additional, Marinissen, Julia, additional, Mariuzza, Roy A., additional, Marmor, Mina D., additional, Martin, G. Steven, additional, Martin, Karen H., additional, Martinez, Sergio E., additional, Mathews, Michael B., additional, Mayer, Bruce J., additional, Mayer, Mark L., additional, Mazzoni, Maria R., additional, McCormick, Frank, additional, McGowan, Clare H., additional, McKay, Melissa M., additional, McKeehan, Wallace L., additional, McLean, Alison J., additional, Means, Anthony R., additional, Meili, Ruedi, additional, Meng, Jingwei, additional, Merchant, Mark, additional, Mercurio, Frank, additional, Milligan, Graeme, additional, Ming, Guo-Li, additional, Minor, Daniel L., additional, Moghal, Nadeem, additional, Møller, Neils Peter H., additional, Mongillo, Marco, additional, Montminy, Marc, additional, Moon, Randall T., additional, Morimoto, Richard I., additional, Moss, Stephen E., additional, Mott, Helen R., additional, Mouta, Carla, additional, Muda, Marco, additional, Mumby, Marc C., additional, Murphy, Gretchen A., additional, Muzi-Falconi, Marco, additional, Nagaraj, Raghavendra, additional, Nahorski, Stefan R., additional, Nairn, Angus C., additional, Nash, Piers, additional, Neel, Benjamin G., additional, Newton, Alexandra C., additional, Nishizuka, Yasutomi, additional, Noel, Joseph P., additional, Nollen, Ellen A.A., additional, Nooren, Irene M.A., additional, O'Connor, Rodney, additional, Offermanns, Stefan, additional, Olender, Tsviya, additional, Ong, Shao-En, additional, Owen, Darerca, additional, Pagliari, Lisa J., additional, Pao, Lily, additional, Papaconstantinou, John, additional, Pardo, Leonardo, additional, Park, Hay-Oak, additional, Park, Young Chul, additional, Parker, Peter J., additional, Parsons, J. Thomas, additional, Passner, J.M., additional, Pawson, Tony, additional, Pelliccioli, Achille, additional, Perez-Polo, J. Regino, additional, Perrimon, Norbert, additional, Petite, Fabrice G., additional, Petroulakis, Emmanuel, additional, Pfaff, Samuel L., additional, Piehler, Jacob, additional, Pike, Linda J., additional, Pinkoski, Michael J., additional, Pixley, Fiona J., additional, Plevani, Paolo, additional, Poo, Mu-ming, additional, Pozzan, Tullioi, additional, Prescott, Stephen M., additional, Prudovsky, Igor, additional, Putney, James W., additional, Radimerski, Thomas, additional, Radzio-Andzelm, Elzbieta, additional, Ram, Prahlad T., additional, Rameh, Lucia, additional, Ramljak, Danica, additional, Ranscht, Barbara, additional, Rao, Anjana, additional, Raport, Carol J., additional, Reeves, Jacqueline D., additional, Rehman, Holger, additional, Reichman, Trevor W., additional, Reiter, Eric, additional, Resnick, Michael A., additional, Reth, Michael, additional, Rhee, Sue Goo, additional, Richter, Joel D., additional, Rietze, Rodney L., additional, Rini, James M., additional, Ripperger, Jürgen A., additional, Rizo, Josep, additional, Robishaw, Janet D., additional, Roderick, H. Llewelyn, additional, Roeder, Robert G., additional, Rohrschneider, Larry R., additional, Ron, David, additional, Rosenfeld, Michael G., additional, Rosenfeldt, Hans, additional, Rossman, Kent L., additional, Roth, Christopher B., additional, Rudolph, Markus G., additional, Ruppelt, Anja, additional, Saez, Lino, additional, Sakmar, Thomas P., additional, Salvesen, Guy S., additional, Sassone-Corsi, Paolo, additional, Saxe, Charles L., additional, Schäfer, Beat W., additional, Schibler, Ueli, additional, Schindler, Christian W., additional, Schmelzle, Tobias, additional, Schmid, Sandra L., additional, Schmidt, Anja, additional, Schmidt, Eric F., additional, Schreiber, Gideon, additional, Schultz, Joachim E., additional, Schwaller, Beat, additional, Schwamborn, Klaus, additional, Schwartz, Thue, additional, Schwindinger, William F., additional, Scita, Giorgio, additional, Scott, John D., additional, Scott, Shaun, additional, Seebeck, Thomas, additional, Serhan, Charles N., additional, Shabb, John B., additional, Shaw, Andrey S., additional, Shears, Stephen B., additional, Shenolikar, Shirish, additional, Shi, Lei, additional, Shin, Chanseok, additional, Shiozaki, Kazuhiro, additional, Shokat, Kevan M., additional, Shuttleworth, Trevor J., additional, Siderovski, David P., additional, Siegelbaum, Steven A., additional, Silverstein, Adam M., additional, Singer, Robert H., additional, Skinner, Michael K., additional, Slack-Davis, Jill K., additional, Smerdon, Stephen J., additional, Smith, Graeme C.M., additional, Smits, Guillaume, additional, Smolik, Sarah M., additional, Smotrys, Jessica E., additional, Smyth, Emer M., additional, Snyder, Jason T., additional, Sogame, Naoko, additional, Soldi, Raffaella, additional, Sondek, John, additional, Sonenberg, Nahum, additional, Sonneberg, Erica Dutil, additional, Sparrow, Lindsay G., additional, Spiegel, Sarah, additional, Sprang, Stephen R., additional, Srivastava, Deepak, additional, Stanfield, Robyn L., additional, Stanley, E. Richard, additional, Stauber, Deborah J., additional, Stefan, Christopher, additional, Stenson-Holst, Lena, additional, Stephens, Len, additional, Sternberg, Paul W., additional, Sternweis, Paul C., additional, Steward, Ruth, additional, Stickney, John T., additional, Stoker, Andrew W., additional, Strittmatter, Stephen M., additional, Stronach, Beth E., additional, Strong, Roland K., additional, Stroud, Robert M., additional, Südhof, Thomas C., additional, Sunahara, Roger K., additional, Sutton, Brian J., additional, Szabolcs, Sipeki, additional, Tang, Xiao-Bo, additional, Taskén, Kjetil, additional, Tatebe, Hisashi, additional, Tauszig-Delamasure, Servane, additional, Taylor, Colin W., additional, Taylor, Garry L., additional, Taylor, Laura J., additional, Taylor, Susan S., additional, Thomas, George, additional, Thomas, Robert P., additional, Thompson, E. Brad, additional, Thompson, Michael J., additional, Thornton, Janet M., additional, Thummel, Carl S., additional, Togashi, Hideaki, additional, Tong, Amy Hin Yan, additional, Tonks, Nicholas K., additional, Tontonoz, Peter, additional, Topham, M.K., additional, Torgersen, Knut Martin, additional, Tran, Hien, additional, Tremblay, Michel L., additional, Tsai, Ming-Jer, additional, Tsai, Sophia Y., additional, Tsunoda, Susan, additional, Turley, Stewart, additional, Tyson, Darren, additional, Van Etten, Robert L., additional, Vassart, Gilbert, additional, Verveer, Peter J., additional, Vlaeminck, Virginie, additional, de Vos, Abraham M., additional, Voss, Ty C., additional, Walczak, Robert, additional, Walker, Graham C., additional, Walker, John C., additional, Walter, Gernot, additional, Walter, Mark R., additional, Wang, Fen, additional, Wang, Jean Y.J., additional, Wang, Weiru, additional, Ward, Richard J., additional, Wedegaertner, Philip, additional, Wehrle, Christian, additional, Weiss, Arthur, additional, Weiss, Jamie L., additional, Wells, Alan, additional, Werner, Claudia, additional, West, Ann H., additional, Weston, Marie C., additional, Westwick, John K., additional, Wetterholm, Anders, additional, White, Morris F., additional, Whitman, Malcolm, additional, Whorton, Matt R., additional, Wiesmann, Christian, additional, Williams, Roger L., additional, Willis, William D., additional, Willson, Timothy M., additional, Wilson, Ian A., additional, Wiser, Ofer, additional, Wishart, Matthew J., additional, Wittinghofer, Alfred, additional, Woodgett, James R., additional, Worthylake, David K., additional, Wrana, Jeffrey L., additional, Wu, Hao, additional, Xiao, Yijin, additional, Xu, H. Eric, additional, Xu, Yan, additional, Xu, Zheng, additional, Yaffe, Michael B., additional, Yamada, Kenneth M., additional, Yang, Seun-Ah, additional, Yang, Wannian, additional, Yarden, Yosef, additional, Ye, Hong, additional, Ye, Weilan, additional, Yeates, Todd O., additional, Yin, Helen L., additional, York, John D., additional, Young, Edgar C., additional, Young, Kenneth W., additional, Young, Matthew A., additional, Young, Michael W., additional, Yu, Minmin, additional, Zaccai, Nathan R., additional, Zaccolo, Manuela, additional, Zamir, Eli, additional, von Zastrow, Mark, additional, Zhang, Chao, additional, Zhang, Xuewu, additional, Zhang, Zhong-Yin, additional, Zhou, Wenhong, additional, and Zoraghi, Roya, additional
Published: 2003
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31. VEGF and the Angiopoietins Activate Numerous Signaling Pathways that Govern Angiogenesis

Author: Daly, Christopher, primary and Holash, Jocelyn, additional
Published: 2003
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32. Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina

Author: Holash, Jocelyn A., Soans, Chandrasen, Chong, Lisa D., Shao, Haining, Dixit, Vishva M., and Pasquale, Elena B.
Subjects: Gene expression -- Research, Protein tyrosine kinase -- Analysis, Retina -- Physiological aspects, Biological sciences
Abstract: Recent evidence suggests that Eph receptor tyrosine kinases and their ligands provide positional information in the developing visual system. We previously found that the Eph receptor Cek5 is more highly expressed in the ventral than dorsal chicken embryonic retina. We now report the identification of a chicken ligand for Cek5 (cCek5-L) that is 75% identical to the ligand LERK2. In situ hybridization experiments do not reveal a dorsoventral gradient of cCek5-L transcripts in the optic tectum at Embryonic Day 8, suggesting that this ligand is not involved in guiding Cek5-expressing axons in the tectum. Surprisingly, it is in the retina that high levels of cCek5-L mRNA are present. In the early retina, cCek5-L is more highly expressed in the dorsal than the ventral aspect. Similarly, a Cek5 Ig chimera labels dorsal but not ventral retina, indicating that even if several Cek5 ligands are present, their overall distribution is complementary to that of Cek5. Hence, Cek5 and cCek5-L may both contribute to define anatomical compartments within the early retina. In contrast, in the 11-day embryonic retina the distributions of Cek5 and its ligand(s) show considerable overlap, suggesting changing functions as development progresses. In dissociated cultures of dorsal or ventral retinal cells seeded on plates coated with either receptor or ligand Ig chimeras, the interaction between Cek5 and its ligand(s) or cCek5-L and its receptor(s) is sufficient to mediate cell adhesion and allows neurite outgrowth.
Published: 1997

33. The Angiopoietins, and How They Act Coordinately with Vascular Endothelial Growth Factor During Normal and Pathologic Angiogenesis

Author: Davis, Samuel, primary, Holash, Jocelyn, additional, Suri, Chitra, additional, Maisonpierre, Peter C, additional, Wiegand, Stanley J, additional, and Yancopoulos, George D, additional
Published: 2001
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34. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system

Author: Holash, Jocelyn A. and Pasquale, Elena B.
Subjects: Protein tyrosine kinase -- Research, Retina -- Research, Chick embryo -- Observations, Biological sciences
Abstract: Receptor protein tyrosine kinases of the Eph subfamily have been proposed to play roles in pattern formation based on their distribution during embryonic development. Cek8 (chicken embryo kinase 5) and Cek8 (chicken embryo kinase 8) are Eph-related kinases highly expressed in the chicken embryonic retina. To assess their potential roles in the development of the visual pathway, we examined their distribution by immunoperoxidase labeling. Cek8 is expressed throughout the pathway of the retinal ganglion cell axons, including the nerve fiber layer of the retina, optic nerve, optic chiasm, and stratum opticum of the tectum. Cek5 immunoreactivity is highly concentrated in only a portion of the optic nerve and optic chiasm, and in retinal cultures, Cek5 is detected in neurons. This prompted us to examine the regional distribution of Cek5 in the developing retina and led to the observation that Cek5 is most concentrated in the ventral aspect. RT-PCR established that the differential regulation of Cek5 expression in different potions of the retina occurs, at the transcriptional level. Immunoblotting analysis revealed that this unusual expression pattern is distinctive for Cek5, as three other members of the Eph subfamily, Cek4, Cek8, and Cek9, are evenly expressed across the dorsal-ventral axis of the retina Both Cek5 and Cek8 are distributed in manners which are consistent with their regulating the outgrowth of retinal ganglion cell axons to the tectum. Furthermore, Cek5 represents the first signal transduction molecule found to exhibit the polarized pattern of expression predicted for proteins that control the specificity of the retinotectal projections.
Published: 1995

35. Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors

Author: Abrams, Tinya, primary, Connor, Anu, additional, Fanton, Christie, additional, Cohen, Steven B., additional, Huber, Thomas, additional, Miller, Kathy, additional, Hong, E. Erica, additional, Niu, Xiaohong, additional, Kline, Janine, additional, Ison-Dugenny, Marjorie, additional, Harris, Sarah, additional, Walker, Dana, additional, Krauser, Klaus, additional, Galimi, Francesco, additional, Wang, Zhen, additional, Ghoddusi, Majid, additional, Mansfield, Keith, additional, Lee-Hoeflich, Si Tuen, additional, Holash, Jocelyn, additional, Pryer, Nancy, additional, Kluwe, William, additional, Ettenberg, Seth A., additional, Sellers, William R., additional, Lees, Emma, additional, Kwon, Paul, additional, Abraham, Judith A., additional, and Schleyer, Siew C., additional
Published: 2018
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36. Safety and efficacy of docetaxel + b-701, a selective inhibitor of FGFR3, in subjects with advanced or metastatic urothelial carcinoma.

Author: Bellmunt, Joaquim, primary, Pal, Sumanta K., additional, Picus, Joel, additional, Kohli, Manish, additional, Arriaga, Yull Edwin, additional, Milowsky, Matthew I., additional, Holash, Jocelyn, additional, Ramies, David Albert, additional, and McGreivy, Jesse S., additional
Published: 2017
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37. Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells

Author: Gale, Nicholas W., Baluk, Peter, Pan, Li, Kwan, Marilyn, Holash, Jocelyn, DeChiara, Thomas M., McDonald, Donald M., and Yancopoulos, George D.
Subjects: Neovascularization -- Genetic aspects, Arteries -- Genetic aspects, Vascular endothelium -- Analysis, Biological sciences
Abstract: The Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands provide critical guidance cues at points of cell-to-cell contact. It has recently been reported that the ephrin-B2 ligand is a molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium. These findings suggested that ephrin-B2 and EphB4 are involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. By using a genetically engineered mouse in which the lacZ coding region substitutes and reports for the ephrin-B2 coding region, we demonstrate that ephrin-B2 expression continues to selectively mark arteries during later embryonic development as well as in the adult. However, as development proceeds, we find that ephrin-B2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall. Furthermore, although ephrin-B2 expression patterns vary in different vascular beds, it can extend into capillaries about midway between terminal arterioles and postcapillary venules, challenging the classical conception that capillaries have neither arterial nor venous identity. In adult settings of angiogenesis, as in tumors or in the female reproductive system, the endothelium of a subset of new vessels strongly expresses ephrin-B2, once again contrary to earlier views that such new vessels lack arterial/venous characteristics and derive from postcapillary venules. While earlier studies had focused on a role for ephrin-B2 during the earliest embryonic stages of arterial/venous determination, our current findings using ephrin-B2 as an arterial marker in the adult challenge prevailing views of the arterial/venous identity of quiescent as well as remodeling adult microvessels and also highlight a possible role for ephrin-B2 in the formation of the arterial muscle wall. Key Words: artery; vein; capillary; Eph; ephrin; receptor tyrosine kinase; pericyte; angiogenesis; vasculogenesis; PECANI; CD31; alpha-smooth muscle actin.
Published: 2001

38. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Author: Burger, Matthew T., primary, Nishiguchi, Gisele, additional, Han, Wooseok, additional, Lan, Jiong, additional, Simmons, Robert, additional, Atallah, Gordana, additional, Ding, Yu, additional, Tamez, Victoriano, additional, Zhang, Yanchen, additional, Mathur, Michelle, additional, Muller, Kristine, additional, Bellamacina, Cornelia, additional, Lindvall, Mika K., additional, Zang, Richard, additional, Huh, Kay, additional, Feucht, Paul, additional, Zavorotinskaya, Tatiana, additional, Dai, Yumin, additional, Basham, Steve, additional, Chan, Julie, additional, Ginn, Elaine, additional, Aycinena, Alex, additional, Holash, Jocelyn, additional, Castillo, Joseph, additional, Langowski, John L., additional, Wang, Yingyun, additional, Chen, Min Y., additional, Lambert, Amy, additional, Fritsch, Christine, additional, Kauffmann, Audry, additional, Pfister, Estelle, additional, Vanasse, K. Gary, additional, and Garcia, Pablo D., additional
Published: 2015
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39. A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Author: Menezes, Daniel L., primary, Holt, Jenny, additional, Tang, Yan, additional, Feng, Jiajia, additional, Barsanti, Paul, additional, Pan, Yue, additional, Ghoddusi, Majid, additional, Zhang, Wei, additional, Thomas, George, additional, Holash, Jocelyn, additional, Lees, Emma, additional, and Taricani, Lorena, additional
Published: 2015
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40. The identification and characterization of a STAT5 gene signature in hematologic malignancies

Author: Sonkin, Dmitriy, primary, Palmer, Michael, additional, Rong, Xianhui, additional, Horrigan, Kim, additional, Regnier, Catherine H., additional, Fanton, Christie, additional, Holash, Jocelyn, additional, Pinzon-Ortiz, Maria, additional, Squires, Matthew, additional, Sirulnik, Andres, additional, Radimerski, Thomas, additional, Schlegel, Robert, additional, Morrissey, Michael, additional, and Cao, Z. Alexander, additional
Published: 2015
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41. Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Author: Garcia, Pablo D., primary, Langowski, John L., additional, Wang, Yingyun, additional, Chen, Min, additional, Castillo, Joseph, additional, Fanton, Christie, additional, Ison, Marjorie, additional, Zavorotinskaya, Tatiana, additional, Dai, Yumin, additional, Lu, Jing, additional, Niu, Xiao-Hong, additional, Basham, Stephen, additional, Chan, Julie, additional, Yu, Jianjun, additional, Doyle, Michael, additional, Feucht, Paul, additional, Warne, Robert, additional, Narberes, Jamie, additional, Tsang, Tiffany, additional, Fritsch, Christine, additional, Kauffmann, Audrey, additional, Pfister, Estelle, additional, Drueckes, Peter, additional, Trappe, Joerg, additional, Wilson, Christopher, additional, Han, Wooseok, additional, Lan, Jiong, additional, Nishiguchi, Gisele, additional, Lindvall, Mika, additional, Bellamacina, Cornelia, additional, Aycinena, J. Alex, additional, Zang, Richard, additional, Holash, Jocelyn, additional, and Burger, Matthew T., additional
Published: 2014
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42. The Pan-PIM Kinase Inhibitor LGH447 Shows Activity In PIM2-Dependent Multiple Myeloma and In AML Models

Author: Garcia, Pablo D, primary, Langowski, John L, additional, Holash, Jocelyn, additional, Burger, Matthew, additional, Zang, Richard, additional, Zavorotinskaya, Tatiana, additional, Fanton, Christie, additional, Saci, Abdel, additional, Growney, Joseph, additional, and Vanasse, K. Gary, additional
Published: 2013
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43. Abstract A140: Evaluation of prediction of in vivo activity from in vitro combinations: Examples using a MEK1/2 inhibitor combined with docetaxel in NSCLC models.

Author: Mcsheehy, Paul Martin J., primary, Cao, Alex, additional, Caponigro, Giordi, additional, Duhl, David, additional, Firestone, Brant, additional, Gesner, Tom, additional, Guthy, Daniel, additional, Holash, Jocelyn, additional, King, Fred, additional, Lehar, Joseph, additional, Leroy, Christopher, additional, Liu, Manway, additional, Petruzzelli, Lilli, additional, Porter, Dale, additional, Menezes, Daniel, additional, Reddy, Anupama, additional, Roesel, Johannes, additional, Schnell, Christian, additional, Smith, Timothy, additional, Stump, Mark, additional, Wartmann, Markus, additional, and Wiesmann, Marion, additional
Published: 2013
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44. Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

Author: Burger, Matthew T., primary, Han, Wooseok, additional, Lan, Jiong, additional, Nishiguchi, Gisele, additional, Bellamacina, Cornelia, additional, Lindval, Mika, additional, Atallah, Gordana, additional, Ding, Yu, additional, Mathur, Michelle, additional, McBride, Chris, additional, Beans, Elizabeth L., additional, Muller, Kristine, additional, Tamez, Victoriano, additional, Zhang, Yanchen, additional, Huh, Kay, additional, Feucht, Paul, additional, Zavorotinskaya, Tatiana, additional, Dai, Yumin, additional, Holash, Jocelyn, additional, Castillo, Joseph, additional, Langowski, John, additional, Wang, Yingyun, additional, Chen, Min Y., additional, and Garcia, Pablo D., additional
Published: 2013
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45. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

Author: Lu, Jing, primary, Zavorotinskaya, Tatiana, additional, Dai, Yumin, additional, Niu, Xiao-Hong, additional, Castillo, Joseph, additional, Sim, Janet, additional, Yu, Jianjun, additional, Wang, Yingyun, additional, Langowski, John L., additional, Holash, Jocelyn, additional, Shannon, Kevin, additional, and Garcia, Pablo D., additional
Published: 2013
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46. Identification of pSTAT5 gene signature in hematologic malignancy.

Author: Sonkin, Dmitriy, primary, Regnier, Catherine, additional, Rong, Xianhui, additional, Fanton, Christie, additional, Palmer, Michael, additional, Holash, Jocelyn, additional, Squires, Matthew, additional, Sirulnik, L. Andres, additional, Radimerski, Thomas, additional, Schlegel, Robert, additional, Morrissey, Michael, additional, and Cao, Z, Alexander, additional
Published: 2013
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47. Abstract 2058: Systematic evaluation of drug combinations in vitro and in vivo.

Author: Wiesmann, Marion, primary, Stump, Mark, additional, Caponigro, Giordano, additional, Duhl, David, additional, Firestone, Brant, additional, Gesner, Tom, additional, Gruenenfelder, Bjoern, additional, Guthy, Daniel Alexander, additional, Holash, Jocelyn, additional, King, Fred, additional, Lehar, Joseph, additional, Leroy, Christophe, additional, Liu, Manway, additional, Petruzelli, Lilli, additional, Porter, Dale, additional, McSheehy, Paul, additional, Menezes, Daniel, additional, Reddy, Anupama, additional, Roesel, Johannes, additional, Schnell, Christian, additional, Smith, Timothy R., additional, and Wartmann, Markus, additional
Published: 2013
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48. Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer

Author: Damiano, Jason S., primary, Rendahl, Katherine G., additional, Karim, Christopher, additional, Embry, Millicent G., additional, Ghoddusi, Majid, additional, Holash, Jocelyn, additional, Fanidi, Abdallah, additional, Abrams, Tinya J., additional, and Abraham, Judith A., additional
Published: 2013
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49. Abstract DDT02-02: Preclinical development of LFA102, a highly potent and selective neutralizing antibody against the prolactin receptor

Author: Damiano, Jason, primary, Rendahl, Katherine, additional, Karim, Christopher, additional, Jeffry, Ursula, additional, Wasserman, Ernesto, additional, Holash, Jocelyn, additional, Rediske, John, additional, Kakar, Shefali, additional, Fanidi, Abdallah, additional, Fang, Eric, additional, Aziz, Natasha, additional, Sim, Janet, additional, Gardner, Humphrey, additional, Luqman, Mohammad, additional, Mirza, Amer, additional, Handa, Masahisa, additional, Neben, Tamara, additional, Beddinger, Daniel, additional, and Abraham, Judith, additional
Published: 2011
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50. VEGF Trap induces antiglioma effect at different stages of disease

Author: Gomez-Manzano, Candelaria, primary, Holash, Jocelyn, additional, Fueyo, Juan, additional, Xu, Jing, additional, Conrad, Charles A., additional, Aldape, Kenneth D., additional, de Groot, John F., additional, Bekele, B. Nebiyou, additional, and Yung, W. K. Alfred, additional
Published: 2008
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