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579 results on '"Hohl, Daniel"'

2. Diaper dermatitis prevalence and severity: Global perspective on the impact of caregiver behavior

Author

Carr, Andrew N, DeWitt, Thomas, Cork, Michael J, Eichenfield, Lawrence F, Fölster‐Holst, Regina, Hohl, Daniel, Lane, Alfred T, Paller, Amy, Pickering, Larry, Taieb, Alain, Cui, Tao Y, Xu, Zi G, Wang, Xeumin, Brink, Susanna, Niu, Yeuqing, Ogle, Julie, Odio, Mauricio, and Gibb, Roger D

Subjects
Pediatric, Clinical Research, Skin, Buttocks, Caregivers, China, Cross-Sectional Studies, Diaper Rash, Diapers, Infant, Female, Germany, Humans, Hydrogen-Ion Concentration, Infant, Infant Care, Male, Prevalence, Surveys and Questionnaires, United States, diaper dermatitis, neonatal, skin barrier, Paediatrics and Reproductive Medicine, Dermatology & Venereal Diseases
Abstract

ObjectivesTo compare prevalence and severity of diaper dermatitis (DD) in infants and toddlers (babies) across three countries (China, USA, and Germany), including diapered skin measures and caregiver practices.MethodsA cross-sectional study of 1791 babies (~600 from each country) was recruited at each clinical site. Based on regional toilet-training habits, exclusively diaper-wearing infants were recruited between ages 2-8 months in China and 2-18 months in the USA and Germany. DD was measured, as well as skin pH, transepidermal water loss (TEWL), and relative humidity (RH) in the diapered region. Caregiver habits were collected via a questionnaire and included information on hygienic practices.ResultsDiaper dermatitis was highest in the perianal area, followed by the intertriginous, genital, and buttock regions. In general, DD was significantly lower in babies in China, highest in Germany, and intermediate in the USA. This rank ordering of DD by geography was also observed in baby age 2-8 months. The lower DD observed in China was associated with lower skin pH and TEWL on diapered skin and decreased RH in the diaper. Chinese caregivers had the highest rate of prophylactic topical product usage, the most robust cleaning of the diapered area, lack of cleansing after urine-only diaper changes, and Chinese infants spent the least time in an overnight diaper.ConclusionsThese data suggest caregiver behaviors including prophylactic use of topical products, thorough cleaning after stooling and reduced time in an overnight diaper are associated with less DD, lower superficial skin pH, and enhanced skin barrier.

Published
2020

9. UVB-Induced Skin Inflammation and Cutaneous Tissue Injury Is Dependent on the MHC Class I–Like Protein, CD1d

Author

Ryser, Stephan, Schuppli, Marlène, Gauthier, Beatrice, Hernandez, Dianelys R, Roye, Olivier, Hohl, Daniel, German, Bruce, Holzwarth, James A, and Moodycliffe, Angus M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Vaccine Related, Prevention, Climate-Related Exposures and Conditions, Biodefense, Cancer, 1.1 Normal biological development and functioning, Aetiology, Underpinning research, 2.1 Biological and endogenous factors, Skin, Inflammatory and immune system, Animals, Antigens, CD1d, Dermatitis, Female, Histocompatibility Antigens Class I, Inflammation Mediators, Killer Cells, Natural, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Sunburn, Ultraviolet Rays, Wound Healing, Clinical Sciences, Dermatology & Venereal Diseases, Clinical sciences
Abstract

CD1d is a major histocompatibility complex class 1-like molecule that regulates the function and development of natural killer T (NKT) cells. Previously, we identified a critical role for the CD1d-NKT cell arm of innate immunity in promoting the development of UVB-induced p53 mutations, immune suppression, and skin tumors. Sunburn, an acute inflammatory response to UVB-induced cutaneous tissue injury, represents a clinical marker for non-melanoma skin cancer (NMSC) risk. However, the innate immune mechanisms controlling sunburn development are not considered relevant in NMSC etiology, and remain poorly investigated. Here we found that CD1d knockout (CD1d(-/-)) mice resist UVB-induced cutaneous tissue injury and inflammation compared with wild-type (WT) mice. This resistance was coupled with a faster epithelial tissue healing response. In contrast, the skins of UVB-irradiated invariant NKT cell-knockout (Jα18(-/-)) and NKT cell-deficient (TCRα(-/-)) mice, which express CD1d but are deficient in CD1d-dependent NKT cells, exhibited as much cutaneous tissue injury and inflammation as WT mice. In the absence of NKT cells, CD1d-deficient keratinocytes, dendritic cells, and macrophages exhibited diminished basal and stress-induced levels of pro-inflammatory mediators. Thus, our findings identify an essential role for CD1d in promoting UVB-induced cutaneous tissue injury and inflammation. They also suggest sunburn and NMSC etiologies are immunologically linked.

Published
2014

10. Localized interstitial granuloma annulare induced by subcutaneous injections for desensitization

Author

Spring, Philipp, Vernez, Maxime, Maniu, Christa-Maria, and Hohl, Daniel

Subjects
Interstitial granuloma annulare, Medicine
Abstract

We describe a patient with interstitial granuloma annulare associated with subcutaneous injection therapy (SIT) for desensitization to a type I allergy. Asymptomatic, erythematous, violaceous annular patches were located at the injection sites on both her arms. Medical history revealed perennial rhinoconjonctivitis treated with SIT (Phostal Stallergen® cat 100% and D. pteronyssinus/D.farinae 50%:50%).

Published
2013

16. IL-17 receptor A and adenosine deaminase 2 deficiency in siblings with recurrent infections and chronic inflammation

Author

Fellmann, Florence, Angelini, Federica, Wassenberg, Jacqueline, Perreau, Matthieu, Arenas Ramirez, Natalia, Simon, Gregoire, Boyman, Onur, Demaria, Olivier, Christen-Zaech, Stephanie, Hohl, Daniel, Belfiore, Marco, von Scheven-Gete, Annette, Gilliet, Michel, Bochud, Pierre-Yves, Perrin, Yannick, Beck Popovic, Maya, Bart, Pierre-Alexandre, Beckmann, Jacques S., Martinet, Danielle, and Hofer, Michaël

Published
2016
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17. Supplemenatary Methods and References from Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

Author

Rolfs, Frank, primary, Huber, Marcel, primary, Kuehne, Andreas, primary, Kramer, Stefan, primary, Haertel, Eric, primary, Muzumdar, Sukalp, primary, Wagner, Johanna, primary, Tanner, Yasmine, primary, Böhm, Friederike, primary, Smola, Sigrun, primary, Zamboni, Nicola, primary, Levesque, Mitchell P., primary, Dummer, Reinhard, primary, Beer, Hans-Dietmar, primary, Hohl, Daniel, primary, Werner, Sabine, primary, and Schäfer, Matthias, primary

Published
2023
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18. Supplementary Figures S1-S9 from Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

Author

Rolfs, Frank, primary, Huber, Marcel, primary, Kuehne, Andreas, primary, Kramer, Stefan, primary, Haertel, Eric, primary, Muzumdar, Sukalp, primary, Wagner, Johanna, primary, Tanner, Yasmine, primary, Böhm, Friederike, primary, Smola, Sigrun, primary, Zamboni, Nicola, primary, Levesque, Mitchell P., primary, Dummer, Reinhard, primary, Beer, Hans-Dietmar, primary, Hohl, Daniel, primary, Werner, Sabine, primary, and Schäfer, Matthias, primary

Published
2023
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19. Supplementary Tables S1-S7 from Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

Author

Rolfs, Frank, primary, Huber, Marcel, primary, Kuehne, Andreas, primary, Kramer, Stefan, primary, Haertel, Eric, primary, Muzumdar, Sukalp, primary, Wagner, Johanna, primary, Tanner, Yasmine, primary, Böhm, Friederike, primary, Smola, Sigrun, primary, Zamboni, Nicola, primary, Levesque, Mitchell P., primary, Dummer, Reinhard, primary, Beer, Hans-Dietmar, primary, Hohl, Daniel, primary, Werner, Sabine, primary, and Schäfer, Matthias, primary

Published
2023
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25. Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas

Author

Bal, Elodie, Park, Hyun-Sook, Belaid-Choucair, Zakia, Kayserili, Hülya, Naville, Magali, Madrange, Marine, Chiticariu, Elena, Hadj-Rabia, Smail, Cagnard, Nicolas, Kuonen, Francois, Bachmann, Daniel, Huber, Marcel, Le Gall, Cindy, Côté, Francine, Hanein, Sylvain, Rosti, Rasim Özgür, Aslanger, Ayca Dilruba, Waisfisz, Quinten, Bodemer, Christine, Hermine, Olivier, Morice-Picard, Fanny, Labeille, Bruno, Caux, Frédéric, Mazereeuw-Hautier, Juliette, Philip, Nicole, Levy, Nicolas, Taieb, Alain, Avril, Marie-Françoise, Headon, Denis J, Gyapay, Gabor, Magnaldo, Thierry, Fraitag, Sylvie, Crollius, Hugues Roest, Vabres, Pierre, Hohl, Daniel, Munnich, Arnold, and Smahi, Asma

Subjects
Hedgehog proteins -- Health aspects, Basal cell carcinoma -- Genetic aspects -- Development and progression -- Care and treatment, Gene mutation -- Health aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Biological sciences, Health
Abstract

Author(s): Elodie Bal (corresponding author) [1, 2]; Hyun-Sook Park [3]; Zakia Belaid-Choucair [1, 2, 4]; Hülya Kayserili [5, 6]; Magali Naville [7, 8, 9]; Marine Madrange [1, 2]; Elena Chiticariu [...]

Published
2017
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27. PTCH1 inactivation is sufficient to cause basaloid follicular hamartoma in paediatric Nevoid basal cell carcinoma syndrome

Author

Blanchard, Gabriela, Yurchenko, Andrey A, Pop, Oltin Tiberiu, Weibel, Lisa, Theiler, Martin, Hauser, Valérie, Fraitag, Sylvie, Guenova, Emmanuella, Flatz, Lukas, Nikolaev, Sergey I, Hohl, Daniel, University of Zurich, Nikolaev, Sergey I, and Hohl, Daniel

Subjects
2708 Dermatology, Infectious Diseases, Skin Neoplasms, Carcinoma, Basal Cell, Hamartoma, Humans, Basal Cell Nevus Syndrome, 610 Medicine & health, Dermatology, 10220 Clinic for Surgery, 2725 Infectious Diseases, Child
Published
2022
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36. Birth of a Melanoma

Author

Bogiatzi, Sofia, primary, Pagnoni, Alessandra, additional, Hohl, Daniel, additional, and Gaide, Olivier, additional

Published
2022
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43. Addendum: Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma

Author

Schaller, Julien, primary, Hajjami, Hélène Maby-El, additional, Rusakiewicz, Sylvie, additional, Ioannidou, Kalliopi, additional, Piazzon, Nathalie, additional, Miles, Alexandra, additional, Golshayan, Déla, additional, Gaide, Olivier, additional, Hohl, Daniel, additional, Speiser, Daniel E., additional, and Schaeuble, Karin, additional

Published
2022
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44. Src is activated by the nuclear receptor peroxisome proliferator‐activated receptor β/δ in ultraviolet radiation‐induced skin cancer

Author

Montagner, Alexandra, Delgado, Maria B, Tallichet‐Blanc, Corinne, Chan, Jeremy S K, Sng, Ming K, Mottaz, Hélène, Degueurce, Gwendoline, Lippi, Yannick, Moret, Catherine, Baruchet, Michael, Antsiferova, Maria, Werner, Sabine, Hohl, Daniel, Al Saati, Talal, Farmer, Pierre J, Tan, Nguan S, Michalik, Liliane, and Wahli, Walter

Published
2014
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45. Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009

Author

Oji, Vinzenz, Tadini, Gianluca, Akiyama, Masashi, Blanchet Bardon, Claudine, Bodemer, Christine, Bourrat, Emmanuelle, Coudiere, Philippe, DiGiovanna, John J., Elias, Peter, Fischer, Judith, Fleckman, Philip, Gina, Michal, Harper, John, Hashimoto, Takashi, Hausser, Ingrid, Hennies, Hans Christian, Hohl, Daniel, Hovnanian, Alain, Ishida-Yamamoto, Akemi, Jacyk, Witold K., Leachman, Sancy, Leigh, Irene, Mazereeuw-Hautier, Juliette, Milstone, Leonard, Morice-Picard, Fanny, Paller, Amy S., Richard, Gabriele, Schmuth, Matthias, Shimizu, Hiroshi, Sprecher, Eli, Van Steensel, Maurice, Taïeb, Alain, Toro, Jorge R., Vabres, Pierre, Vahlquist, Anders, Williams, Mary, and Traupe, Heiko

Published
2010
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49. Case Report: Pansclerotic Morphea-Clinical Features, Differential Diagnoses and Modern Treatment Concepts

Author

Ventéjou, Sarah, Schwieger-Briel, Agnes, Nicolai, Rebecca, Christen-Zaech, Stephanie, Schnider, Caroline, Hofer, Michael, Bogiatzi, Sofia, Hohl, Daniel, De Benedetti, Fabrizio, Morren, Marie-Anne, Ventéjou, Sarah, Schwieger-Briel, Agnes, Nicolai, Rebecca, Christen-Zaech, Stephanie, Schnider, Caroline, Hofer, Michael, Bogiatzi, Sofia, Hohl, Daniel, De Benedetti, Fabrizio, and Morren, Marie-Anne

Abstract

Pansclerotic morphea (PSM) is a rare skin disease characterized by progressive stiffening of the skin with or without the typical superficial skin changes usually seen in morphea (localized scleroderma). Standard therapy, consisting of a combination of systemic glucocorticoids and methotrexate or mycophenolate mofetil, does rarely stop disease progression, which may lead to severe cutaneous sclerosis and secondary contractures. Little is known about the efficacy of newer biologicals such as abatacept, a fusion protein antibody against CTLA-4, or tocilizumab, a fully humanized IL-6R antibody, in the treatment of this pathology. We present the case of an 8 years old girl with an unusual, progressive stiffening of the skin, which was eventually diagnosed as pansclerotic morphea. A treatment with systemic glucocorticoids and methotrexate combined with tocilizumab led to a good clinical response within 2 months after initiation. In this paper, we discuss differential diagnoses to be considered and this new promising treatment option based on a case review of the literature.

Published
2021

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