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15 results on '"Hog̈enauer, Christoph"'

1. A multicenter prospective study on the diagnostic performance of a new liquid rapid urease test for the diagnosis of Helicobacter pylori infection

Author

Dolak, Werner, Bilgilier, Ceren, Stadlmann, Alexander, Leiner, Judith, Puspok, Andreas, Plieschnegger, Wolfgang, Siebert, Franz, Wewalka, Friedrich, Schofl, Rainer, Huber-Schonauer, Ursula, Datz, Christian, Biowski-Frotz, Susanne, Hogenauer, Christoph, Schrutka-Kolbl, Christiane, Makristathis, Athanasios, Schoniger-Hekele, Maximilian, and Steininger, Christoph

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Helicobacter infections -- Diagnosis -- Health aspects, Medical tests -- Health aspects, Hydrolases -- Health aspects, Helicobacter pylori -- Health aspects, Infection -- Diagnosis -- Health aspects, Endoscopy -- Health aspects, Enzymes -- Health aspects, Gastrointestinal diseases -- Diagnosis -- Health aspects, Health
Abstract

Author(s): Werner Dolak[sup.1] , Ceren Bilgilier[sup.2] , Alexander Stadlmann[sup.2] , Judith Leiner[sup.3] , Andreas Püspök[sup.4] , Wolfgang Plieschnegger[sup.5] , Franz Siebert[sup.5] , Friedrich Wewalka[sup.6] , Rainer Schöfl[sup.6] , Ursula Huber-Schönauer[sup.7] [...]

Published
2017
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2. ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment

Author

Adamina, Michel, Bonovas, Stefanos, Raine, Tim, Spinelli, Antonino, Warusavitarne, Janindra, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, Doherty, Glen, El-Hussuna, Alaa, Ellul, Pierre, Fiorino, Gionata, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gisbert, Javier P, Gomollon, Fernando, Lorenzo, Marien Gonzalez, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantinos, Kopylov, Uri, Krustins, Eduards, Kucharzik, Torsten, Lytras, Theodore, Maaser, Christian, Magro, Fernando, Marshall, John Kenneth, Myrelid, Par, Pellino, Gianluca, Rosa, Isadora, Sabino, Joao, Savarino, Edoardo, Stassen, Laurents, Torres, Joana, Uzzan, Mathieu, Vavricka, Stephan, Verstockt, Bram, Zmora, Oded, Akyuz, Filiz, Atreya, Raja, De Acosta, Manuel Barreiro, Bettenworth, Dominik, Bjorkesten, Clas-Goran, Bogut, Ante, Calabrese, Emma, Cvetkovic, Mirjana, Dewint, Pieter, Djuranovic, Srdjan, Drobne, David, Duricova, Dana, Filippi, Jerome, Hogenauer, Christoph, Kaimakliotis, Ioannis, Kiudelis, Gediminas, Klopocka, Maria, Koutroubakis, Ioannis, Krznaric, Zeljko, Laja, Hendrik, Moschen, Alexander, Novak, Gregor, Potapov, Alexander, Tuire, Ilus, Turcan, Svetlana, van Dop, Willemijn, van Schaik, Fiona, Vieira, Ana Isabel, Viennot, Stephanie, Wildt, Signe, Adamina, Michel, Bonovas, Stefano, Raine, Tim, Spinelli, Antonino, Warusavitarne, Janindra, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, Doherty, Glen, El-Hussuna, Alaa, Ellul, Pierre, Fiorino, Gionata, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gisbert, Javier P, Gomollon, Fernando, Lorenzo, Marien González, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantino, Kopylov, Uri, Krustins, Eduard, Kucharzik, Torsten, Lytras, Theodore, Maaser, Christian, Magro, Fernando, Marshall, John Kenneth, Myrelid, Pär, Pellino, Gianluca, Rosa, Isadora, Sabino, Joao, Savarino, Edoardo, Stassen, Laurent, Torres, Joana, Uzzan, Mathieu, Vavricka, Stephan, Verstockt, Bram, Zmora, Oded, Surgery, MUMC+: MA Heelkunde (9), MUMC+: MA AIOS Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Adamina M., Bonovas S., Raine T., Spinelli A., Warusavitarne J., Armuzzi A., Bachmann O., Bager P., Biancone L., Bokemeyer B., Bossuyt P., Burisch J., Collins P., Doherty G., El-Hussuna A., Ellul P., Fiorino G., Frei-Lanter C., Furfaro F., Gingert C., Gionchetti P., Gisbert J.P., Gomollon F., Gonzalez Lorenzo M., Gordon H., Hlavaty T., Juillerat P., Katsanos K., Kopylov U., Krustins E., Kucharzik T., Lytras T., Maaser C., Magro F., Marshall J.K., Myrelid P., Pellino G., Rosa I., Sabino J., Savarino E., Stassen L., Torres J., Uzzan M., Vavricka S., Verstockt B., and Zmora O.

Subjects
Crohn’s disease, intersphincteric fistula tract, pouch-anal anastomosis, inflammatory bowel disease [IBD], FECAL DIVERSION, Disease, Inflammatory bowel disease, surgery, vedolizumab-treated patients, Crohn Disease, Maintenance therapy, Induction therapy, Intestine, Small, EVIDENCE-BASED CONSENSUS, Medicine, POSTOPERATIVE COMPLICATIONS, Certolizumab pegol, 610 Medicine & health, Surgical treatment, POUCH-ANAL ANASTOMOSIS, TO-END ANASTOMOSIS, Crohn's disease, Gastroenterology, ANTI-TNF THERAPY, General Medicine, Inflammatory bowel disease (IBD), Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Abdominal Abscess, MEDLINE, postoperative complications, Humans, Rectal Fistula, INTRAABDOMINAL SEPTIC COMPLICATIONS, Intensive care medicine, VEDOLIZUMAB-TREATED PATIENTS, Science & Technology, evidence-based consensus, Gastroenterology & Hepatology, inflammatory-bowel-disease, intraabdominal septic complications, business.industry, medicine.disease, INTERSPHINCTERIC FISTULA TRACT, business, Intestinal Obstruction, INFLAMMATORY-BOWEL-DISEASE
Abstract

This article is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease. The first article covers medical management; the present article addresses surgical management, including preoperative aspects and drug management before surgery. It also provides technical advice for a variety of common clinical situations. Both articles together represent the evidence-based recommendations of the ECCO for Crohn's disease and an update of previous guidelines. ispartof: JOURNAL OF CROHNS & COLITIS vol:14 issue:2 pages:155-168 ispartof: location:England status: published

Published
2019

3. A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Author

Keller, Josbert J., Ooijevaar, Rogier E., Hvas, Christian L., Terveer, Elisabeth M., Lieberknecht, Simone C., Hogenauer, Christoph, Arkkila, Perttu, Sokol, Harry, Gridnyev, Oleksiy, Megraud, Francis, Kump, Patrizia K., Nakov, Radislav, Goldenberg, Simon D., Satokari, Reetta, Tkatch, Sergiy, Sanguinetti, Maurizio, Cammarota, Giovanni, Dorofeev, Andrey, Gubska, Olena, Laniro, Gianluca, Mattila, Eero, Arasaradnam, Ramesh P., Sarin, Shiv K., Sood, Ajit, Putignani, Lorenza, Alric, Laurent, Baunwall, Simon M. D., Kupcinskas, Juozas, Link, Alexander, Goorhuis, Abraham G., Verspaget, Hein W., Ponsioen, Cyriel, Hold, Georgina L., Tilg, Herbert, Kassam, Zain, Kuijper, Ed J., Gasbarrini, Antonio, Mulder, Chris J. J., Williams, Horace R. T., Vehreschild, Maria J. G. T., Keller, Josbert J., Ooijevaar, Rogier E., Hvas, Christian L., Terveer, Elisabeth M., Lieberknecht, Simone C., Hogenauer, Christoph, Arkkila, Perttu, Sokol, Harry, Gridnyev, Oleksiy, Megraud, Francis, Kump, Patrizia K., Nakov, Radislav, Goldenberg, Simon D., Satokari, Reetta, Tkatch, Sergiy, Sanguinetti, Maurizio, Cammarota, Giovanni, Dorofeev, Andrey, Gubska, Olena, Laniro, Gianluca, Mattila, Eero, Arasaradnam, Ramesh P., Sarin, Shiv K., Sood, Ajit, Putignani, Lorenza, Alric, Laurent, Baunwall, Simon M. D., Kupcinskas, Juozas, Link, Alexander, Goorhuis, Abraham G., Verspaget, Hein W., Ponsioen, Cyriel, Hold, Georgina L., Tilg, Herbert, Kassam, Zain, Kuijper, Ed J., Gasbarrini, Antonio, Mulder, Chris J. J., Williams, Horace R. T., and Vehreschild, Maria J. G. T.

Abstract

Background Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of faeces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council. Objective Several European and international consensus statements concerning faecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document. Methods Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about faecal microbiota transplantation. Results A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening. Conclusion The implementation of faecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor faeces preparations for patients.

Published
2021

4. Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitis

Author

Hogenauer, Christoph, Langner, Cord, Schicho, Rudolf, Gorkiewicz, Gregor, Krause, Robert, Gerstgrasser, Nikolas, Beubler, Eckhard, and Lippe, Irmgard T.

Subjects
Klebsiella -- Risk factors, Klebsiella -- Causes of, Klebsiella -- Drug therapy, Clostridium difficile -- Risk factors, Clostridium difficile -- Causes of, Clostridium difficile -- Drug therapy
Abstract

An in vivo animal model was developed to establish a causal link between antibiotic-associated hemorrhagic colitis and toxigenic Klebsiella oxytoca according to Koch's postulates. Koch's postulates for cytotoxin-producing Klebsiella oxytoca suggests that it is the causative organism in at least some cases of antibiotic-associated hemorrhagic colitis and infection with Klebsiella oxytoca that should be considered in patients with antibiotic-associated colitis who are negative for Clostridium difficile.

Published
2006

5. Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubulestabilizing activities

Author

European Commission, Ministerio de Economía y Competitividad (España), Schneditz, Georg [0000-0001-6734-5861], Kienesberger, Sabine [0000-0003-3190-3678], Kitsera, Maksym [0000-0003-1214-1313], Josa-Prado, Fernando [0000-0002-6162-3231], Roier, Sandro [0000-0003-2429-9839], Lucena-Agell, Daniel [0000-0001-7198-2900], Barasoain, Isabel [0000-0003-2013-085X], Kroutil, Wolfgang [0000-0002-2151-6394], Loizou, Joanna I. [0000-0003-1853-0424], Breinbauer, Rolf [0000-0001-6009-7359], Díaz, José Fernando [0000-0003-2743-3319], Schild, Stefan [0000-0001-7842-0177], Zechner, Ellen L. [0000-0003-2035-1898], Unterhauser, Katrin, Poltl, Lisa, Schneditz, Georg, Kienesberger, Sabine, Glabonjat, Ronald A., Kitsera, Maksym, Pletz, Jakob, Josa-Prado, Fernando, Dornisch, Elisabeth, Lembacher-Fadum, Christian, Roier, Sandro, Gorkiewicz, Gregor, Lucena-Agell, Daniel, Barasoain, Isabel, Kroutil, Wolfgang, Wiedner, Marc, Loizou, Joanna I., Breinbauer, Rolf, Díaz, José Fernando, Schild, Stefan, Hog̈enauer, Christoph, Zechner, Ellen L., European Commission, Ministerio de Economía y Competitividad (España), Schneditz, Georg [0000-0001-6734-5861], Kienesberger, Sabine [0000-0003-3190-3678], Kitsera, Maksym [0000-0003-1214-1313], Josa-Prado, Fernando [0000-0002-6162-3231], Roier, Sandro [0000-0003-2429-9839], Lucena-Agell, Daniel [0000-0001-7198-2900], Barasoain, Isabel [0000-0003-2013-085X], Kroutil, Wolfgang [0000-0002-2151-6394], Loizou, Joanna I. [0000-0003-1853-0424], Breinbauer, Rolf [0000-0001-6009-7359], Díaz, José Fernando [0000-0003-2743-3319], Schild, Stefan [0000-0001-7842-0177], Zechner, Ellen L. [0000-0003-2035-1898], Unterhauser, Katrin, Poltl, Lisa, Schneditz, Georg, Kienesberger, Sabine, Glabonjat, Ronald A., Kitsera, Maksym, Pletz, Jakob, Josa-Prado, Fernando, Dornisch, Elisabeth, Lembacher-Fadum, Christian, Roier, Sandro, Gorkiewicz, Gregor, Lucena-Agell, Daniel, Barasoain, Isabel, Kroutil, Wolfgang, Wiedner, Marc, Loizou, Joanna I., Breinbauer, Rolf, Díaz, José Fernando, Schild, Stefan, Hog̈enauer, Christoph, and Zechner, Ellen L.

Abstract

Establishing causal links between bacterial metabolites and human intestinal disease is a significant challenge. This study reveals the molecular basis of antibiotic-associated hemorrhagic colitis (AAHC) caused by intestinal resident Klebsiella oxytoca Colitogenic strains produce the nonribosomal peptides tilivalline and tilimycin. Here, we verify that these enterotoxins are present in the human intestine during active colitis and determine their concentrations in a murine disease model. Although both toxins share a pyrrolobenzodiazepine structure, they have distinct molecular targets. Tilimycin acts as a genotoxin. Its interaction with DNA activates damage repair mechanisms in cultured cells and causes DNA strand breakage and an increased lesion burden in cecal enterocytes of colonized mice. In contrast, tilivalline binds tubulin and stabilizes microtubules leading to mitotic arrest. To our knowledge, this activity is unique for microbiota-derived metabolites of the human intestine. The capacity of both toxins to induce apoptosis in intestinal epithelial cells-a hallmark feature of AAHC-by independent modes of action, strengthens our proposal that these metabolites act collectively in the pathogenicity of colitis.

Published
2019

8. A physicians' wish list for the clinical application of intestinal metagenomics

Author

Klymiuk, Ingeborg, Hogenauer, Christoph, Halwachs, Bettina, Thallinger, Gerhard G., Fricke, W. Florian, and Steininger, Christoph

Subjects
Genomics -- Research, Genetic research, Intestines -- Genetic aspects, Microbial colonies -- Genetic aspects, Microbiological research, Biological sciences
Abstract

Introduction The intestine is one of the most diverse and complex bacterial habitats of the human body, harboring ~1,000 bacterial phylotypes [1]. Recent studies have associated the human intestinal microbiome [...]

Published
2014
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11. Puumala virus RNA in patient with multiorgan failure

Author

Hoier, Stefan, Aberle, Stephan W., Langner, Cord, Schnedl, Wolfgang, Hogenauer, Christoph, Reisinger, Emil C., Krejs, Gunter J., and Krause, Robert

Subjects
Hantavirus infections -- Diagnosis, Hantavirus infections -- Risk factors, Hantavirus infections -- Case studies
Abstract

To the Editor: The hantaviruses (genus Hantavirus, family Bunyaviridae) include human pathogens and occur worldwide (1). In Western and Central Europe, the predominant serotype is Puumala virus (PUUV), which causes [...]

Published
2006

12. European consensus conference on faecal microbiota transplantation in clinical practice

Author

Cammarota, Giovanni, Ianiro, Gianluca, Tilg, Herbert, Rajilić-Stojanovićć, Mirjana, Kump, Patrizia, Satokari, Reetta, Sokol, Harry, Arkkila, Perttu, Pintus, Cristina, Hart, Ailsa, Segal, Jonathan, Aloi, Marina, Masucci, Luca, Molinaro, Antonio, Scaldaferri, Franco, Gasbarrini, Giovanni, Lopez-Sanroman, Antonio, Link, Alexander, de Groot, Pieter, de Vos, Willem M, Hogenauer, Christoph, Malfertheiner, Peter, Mattila, Eero, Milosavljeviććć, Tomica, Nieuwdorp, Max, Sanguinetti, Maurizio, Simren, Magnus, and Gasbarrini, Antonio

Abstract

Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficileinfection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficileinfection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.

Published
2017
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15. Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect.

Author

Russo, Michael A., Hogenauer, Christoph, Coates Jr., Stephen W., Santa Ana, Carol A., Porter, Jack L., Rosenblatt, Randall L., Emmett, Michael, Fordtran, John S., and Coates, Stephen W Jr

Subjects
*CYSTIC fibrosis, *ABSORPTION, *FLUIDS, *ELECTROLYTES, *JEJUNUM, *PERFUSION, *UREA metabolism, *BICARBONATE ions, *CHLORIDES, *COMPARATIVE studies, *DIFFUSION, *INTESTINAL absorption, *RESEARCH methodology, *MEDICAL cooperation, *MEMBRANE proteins, *MONOSACCHARIDES, *RESEARCH, *EVALUATION research
Abstract

Due to genetic defects in apical membrane chloride channels, the cystic fibrosis (CF) intestine does not secrete chloride normally. Depressed chloride secretion leaves CF intestinal absorptive processes unopposed, which results in net fluid hyperabsorption, dehydration of intestinal contents, and a propensity to inspissated intestinal obstruction. This theory is based primarily on in vitro studies of jejunal mucosa. To determine if CF patients actually hyperabsorb fluid in vivo, we measured electrolyte and water absorption during steady-state perfusion of the jejunum. As expected, chloride secretion was abnormally low in CF, but surprisingly, there was no net hyperabsorption of sodium or water during perfusion of a balanced electrolyte solution. This suggested that fluid absorption processes are reduced in CF jejunum, and further studies revealed that this was due to a marked depression of passive chloride absorption. Although Na+-glucose cotransport was normal in the CF jejunum, absence of passive chloride absorption completely blocked glucose-stimulated net sodium absorption and reduced glucose-stimulated water absorption 66%. This chloride absorptive abnormality acts in physiological opposition to the classic chloride secretory defect in the CF intestine. By increasing the fluidity of intraluminal contents, absence of passive chloride absorption may reduce the incidence and severity of intestinal disease in patients with CF. [ABSTRACT FROM AUTHOR]

Published
2003
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