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Your search keyword '"Hofstoetter, Ursula S."' showing total 48 results
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48 results on '"Hofstoetter, Ursula S."'

9. List of contributors

Author

Agullo, Jose Luis, primary, Amassian, Vahe E., additional, Arle, Jeffrey E., additional, Arranz, Beatriz Arranz, additional, Balzer, Jeffrey R., additional, Bello, Lorenzo, additional, Borghei, Alireza, additional, Boström, Azize, additional, Bricolo, Albino, additional, Brinzeu, Andrei, additional, Candocia, Alexander, additional, Chudy, Darko, additional, Climent, Alejandra, additional, Coscujuela, Antonio, additional, Crammond, Donald J., additional, de Meo, Federico, additional, Deletis, Vedran, additional, Dinkel, Michael, additional, D’Amico, Alberto, additional, Epstein, Fred, additional, Fernández-Conejero, Isabel, additional, Ferreira, Carla Araujo, additional, Fontes, Ricardo B.V., additional, Fornia, Luca, additional, Frank, Nicole, additional, Freundl, Brigitta, additional, Gay, Lorenzo, additional, Georgoulis, George, additional, Giampiccolo, Davide, additional, Goto, Tetsuya, additional, Guiroy, Alfredo, additional, Haberl, Hannes, additional, Happel, Leo, additional, Hofstoetter, Ursula S., additional, Holdefer, Robert N., additional, Kline, David, additional, Kochanski, Ryan, additional, Kodama, Kunihiko, additional, Koht, Antoun, additional, Kothbauer, Karl F., additional, Leonetti, Antonella, additional, Levitin, Gregory, additional, MacDonald, David B., additional, Malcharek, Michael J., additional, Minassian, Karen, additional, Møller, Aage R., additional, Morota, Nobuhito, additional, Moul, Marina, additional, Neuloh, Georg, additional, Ney, John P., additional, Nibali, Marco Conti, additional, Niimi, Yasunari, additional, Parisi, Cristiano, additional, Pasquali, Claudia, additional, Pessina, Federico, additional, Puglisi, Guglielmo, additional, Raabe, Andreas, additional, Raguž, Marina, additional, Ribas, Manuel, additional, Riva, Marco, additional, Rossi, Marco, additional, Sala, Francesco, additional, Sani, Sepehr, additional, Schneider, Gerhard, additional, Schramm, Johannes, additional, Sciortino, Tommaso, additional, Seidel, Kathleen, additional, Sekula, Raymond F., additional, Shils, Jay L., additional, Sinclair, Catherine F., additional, Sindou, Marc, additional, Skinner, Stanley A., additional, Sloan, Tod B., additional, Stecker, Mark M., additional, Szelényi, Andrea, additional, Téllez, Maria J., additional, Thirumala, Parthasarathy, additional, Toleikis, J. Richard, additional, Tramontano, Vincenzo, additional, Ulkatan, Sedat, additional, Urriza, Javier, additional, van der Goes, David N., additional, Vodušek, David B., additional, and Zubak, Irena, additional

Published
2020
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15. Rare phenomena of central rhythm and pattern generation in a case of complete spinal cord injury.

Author

Minassian, Karen, Bayart, Aymeric, Lackner, Peter, Binder, Heinrich, Freundl, Brigitta, and Hofstoetter, Ursula S.

Subjects
SPINAL cord injuries, CENTRAL pattern generators, QUADRUPEDALISM, SPASMS, RHYTHM, HINDLIMB
Abstract

Lumbar central pattern generators (CPGs) control the basic rhythm and coordinate muscle activation underlying hindlimb locomotion in quadrupedal mammals. The existence and function of CPGs in humans have remained controversial. Here, we investigated a case of a male individual with complete thoracic spinal cord injury who presented with a rare form of self-sustained rhythmic spinal myoclonus in the legs and rhythmic activities induced by epidural electrical stimulation (EES). Analysis of muscle activation patterns suggested that the myoclonus tapped into spinal circuits that generate muscle spasms, rather than reflecting locomotor CPG activity as previously thought. The EES-induced patterns were fundamentally different in that they included flexor-extensor and left-right alternations, hallmarks of locomotor CPGs, and showed spontaneous errors in rhythmicity. These motor deletions, with preserved cycle frequency and period when rhythmic activity resumed, were previously reported only in animal studies and suggest a separation between rhythm generation and pattern formation. Spinal myoclonus and the EES-induced activity demonstrate that the human lumbar spinal cord contains distinct mechanisms for generating rhythmic multi-muscle patterns. The existence of dedicated spinal circuits generating locomotion in humans has remained controversial. Here, the authors study distinct forms of spontaneous and induced rhythmic leg activity in a paralyzed individual, providing insight into spinal rhythmogenesis and pattern formation. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Immediate Effects of Transcutaneous Spinal Cord Stimulation on Motor Function in Chronic, Sensorimotor Incomplete Spinal Cord Injury

Author

Meyer, Christian, Hofstoetter, Ursula S; https://orcid.org/0000-0002-3156-6483, Hubli, Michèle, Hassani, Roushanak H, Rinaldo, Carmen; https://orcid.org/0000-0003-3276-4964, Curt, Armin, Bolliger, Marc, Meyer, Christian, Hofstoetter, Ursula S; https://orcid.org/0000-0002-3156-6483, Hubli, Michèle, Hassani, Roushanak H, Rinaldo, Carmen; https://orcid.org/0000-0003-3276-4964, Curt, Armin, and Bolliger, Marc

Abstract

Deficient ankle control after incomplete spinal cord injury (iSCI) often accentuates walking impairments. Transcutaneous electrical spinal cord stimulation (tSCS) has been shown to augment locomotor activity after iSCI, presumably due to modulation of spinal excitability. However, the effects of possible excitability modulations induced by tSCS on ankle control have not yet been assessed. This study investigated the immediate (i.e., without training) effects during single-sessions of tonic tSCS on ankle control, spinal excitability, and locomotion in ten individuals with chronic, sensorimotor iSCI (American Spinal Injury Association Impairment Scale D). Participants performed rhythmic ankle movements (dorsi- and plantar flexion) at a given rate, and irregular ankle movements following a predetermined trajectory with and without tonic tSCS at 15 Hz, 30 Hz, and 50 Hz. In a subgroup of eight participants, the effects of tSCS on assisted over-ground walking were studied. Furthermore, the activity of a polysynaptic spinal reflex, associated with spinal locomotor networks, was investigated to study the effect of the stimulation on the dedicated spinal circuitry associated with locomotor function. Tonic tSCS at 30 Hz immediately improved maximum dorsiflexion by +4.6° ± 0.9° in the more affected lower limb during the rhythmic ankle movement task, resulting in an increase of +2.9° ± 0.9° in active range of motion. Coordination of ankle movements, assessed by the ability to perform rhythmic ankle movements at a given target rate and to perform irregular movements according to a trajectory, was unchanged during stimulation. tSCS at 30 Hz modulated spinal reflex activity, reflected by a significant suppression of pathological activity specific to SCI in the assessed polysynaptic spinal reflex. During walking, there was no statistical group effect of tSCS. In the subgroup of eight assessed participants, the three with the lowest as well as the one with the highest walking functi

Published
2020

48. Combined Transcutaneous Spinal Stimulation and Locomotor Training to Improve Walking Function and Reduce Spasticity in Subacute Spinal Cord Injury: A Randomized Study of Clinical Feasibility and Efficacy.

Author

Estes, Stephen, Zarkou, Anastasia, Hope, Jasmine M., Suri, Cazmon, Field-Fote, Edelle C., Hofstoetter, Ursula S., and Minassian, Karen

Subjects
SPINAL cord, SPINAL cord injuries, SPASTICITY, CERVICAL cord, WALKING speed
Abstract

Locomotor training (LT) is intended to improve walking function and can also reduce spasticity in motor-incomplete spinal cord injury (MISCI). Transcutaneous spinal stimulation (TSS) also influences these outcomes. We assessed feasibility and preliminary efficacy of combined LT + TSS during inpatient rehabilitation in a randomized, sham-controlled, pragmatic study. Eighteen individuals with subacute MISCI (2–6 months post-SCI) were enrolled and randomly assigned to the LT + TSS or the LT + TSSsham intervention group. Participants completed a 4-week program consisting of a 2-week wash-in period (LT only) then a 2-week intervention period (LT + TSS or LT + TSSsham). Before and after each 2-week period, walking (10 m walk test, 2-min walk test, step length asymmetry) and spasticity (pendulum test, clonus drop test, modified spinal cord injury—spasticity evaluation tool) were assessed. Sixteen participants completed the study. Both groups improved in walking speed and distance. While there were no significant between-groups differences, the LT + TSS group had significant improvements in walking outcomes following the intervention period; conversely, improvements in the LT + TSSsham group were not significant. Neither group had significant changes in spasticity, and the large amount of variability in spasticity may have obscured ability to observe change in these measures. TSS is a feasible adjunct to LT in the subacute stage of SCI and may have potential to augment training-related improvements in walking outcomes. [ABSTRACT FROM AUTHOR]

Published
2021
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