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1. Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumours in the lungNENomics project

Author

Mathian, É., Drouet, Y., Sexton-Oates, A., Papotti, M.G., Pelosi, G., Vignaud, J.-M., Brcic, L., Mansuet-Lupo, A., Damiola, F., Altun, C., Berthet, J.-P., Fournier, C.B., Brustugun, O.T., Centonze, G., Chalabreysse, L., de Montpréville, V.T., di Micco, C.M., Fadel, E., Gadot, N., Graziano, P., Hofman, P., Hofman, V., Lacomme, S., Lund-Iversen, M., Mangiante, L., Milione, M., Muscarella, L.A., Perrin, C., Planchard, G., Popper, H., Rousseau, N., Roz, L., Sabella, G., Tabone-Eglinger, S., Voegele, C., Volante, M., Walter, T., Dingemans, A.-M., Moonen, L., Speel, E.J., Derks, J., Girard, N., Chen, L., Alcala, N., Fernandez-Cuesta, L., Lantuejoul, S., and Foll, M.

Published
2024
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2. Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future

Author

Hofman, P., Ilié, M., Chamorey, E., Brest, P., Schiappa, R., Nakache, V., Antoine, M., Barberis, M., Begueret, H., Bibeau, F., Bonnetaud, C., Boström, P., Brousset, P., Bubendorf, L., Carvalho, L., Cathomas, G., Cazes, A., Chalabreysse, L., Chenard, M.-P., Copin, M.-C., Côté, J.-F., Damotte, D., de Leval, L., Delongova, P., Thomas de Montpreville, V., de Muret, A., Dema, A., Dietmaier, W., Evert, M., Fabre, A., Forest, F., Foulet, A., Garcia, S., Garcia-Martos, M., Gibault, L., Gorkiewicz, G., Jonigk, D., Gosney, J., Hofman, A., Kern, I., Kerr, K., Kossai, M., Kriegsmann, M., Lassalle, S., Long-Mira, E., Lupo, A., Mamilos, A., Matěj, R., Meilleroux, J., Ortiz-Villalón, C., Panico, L., Panizo, A., Papotti, M., Pauwels, P., Pelosi, G., Penault-Llorca, F., Pop, O., Poté, N., Cajal, S.R.Y., Sabourin, J.-C., Salmon, I., Sajin, M., Savic-Prince, S., Schildhaus, H.-U., Schirmacher, P., Serre, I., Shaw, E., Sizaret, D., Stenzinger, A., Stojsic, J., Thunnissen, E., Timens, W., Troncone, G., Werlein, C., Wolff, H., Berthet, J.-P., Benzaquen, J., Marquette, C.-H., Hofman, V., and Calabrese, F.

Published
2021
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3. Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumours in the lungNENomics project

Author

Mathian, Drouet, Y., Sexton-Oates, A., Papotti, M. G., Pelosi, G., Vignaud, J. M., Brcic, L., Mansuet-Lupo, A., Damiola, F., Altun, C., Berthet, J. P., Fournier, C. B., Brustugun, O. T., Centonze, G., Chalabreysse, L., de Montpréville, V. T., di Micco, C. M., Fadel, E., Gadot, N., Graziano, P., Hofman, P., Hofman, V., Lacomme, S., Lund-Iversen, M., Mangiante, L., Milione, M., Muscarella, L. A., Perrin, C., Planchard, G., Popper, H., Rousseau, N., Roz, L., Sabella, G., Tabone-Eglinger, S., Voegele, C., Volante, M., Walter, T., Dingemans, A. M., Moonen, L., Speel, E. J., Derks, J., Girard, N., Chen, L., Alcala, N., Fernandez-Cuesta, L., Lantuejoul, S., Foll, M., Mathian, Drouet, Y., Sexton-Oates, A., Papotti, M. G., Pelosi, G., Vignaud, J. M., Brcic, L., Mansuet-Lupo, A., Damiola, F., Altun, C., Berthet, J. P., Fournier, C. B., Brustugun, O. T., Centonze, G., Chalabreysse, L., de Montpréville, V. T., di Micco, C. M., Fadel, E., Gadot, N., Graziano, P., Hofman, P., Hofman, V., Lacomme, S., Lund-Iversen, M., Mangiante, L., Milione, M., Muscarella, L. A., Perrin, C., Planchard, G., Popper, H., Rousseau, N., Roz, L., Sabella, G., Tabone-Eglinger, S., Voegele, C., Volante, M., Walter, T., Dingemans, A. M., Moonen, L., Speel, E. J., Derks, J., Girard, N., Chen, L., Alcala, N., Fernandez-Cuesta, L., Lantuejoul, S., and Foll, M.

Abstract

Background: Six thoracic pathologists reviewed 259 lung neuroendocrine tumours (LNETs) from the lungNENomics project, with 171 of them having associated survival data. This cohort presents a unique opportunity to assess the strengths and limitations of current World Health Organization (WHO) classification criteria and to evaluate the utility of emerging markers. Patients and methods: Patients were diagnosed based on the 2021 WHO criteria, with atypical carcinoids (ACs) defined by the presence of focal necrosis and/or 2-10 mitoses per 2 mm2. We investigated two markers of tumour proliferation: the Ki-67 index and phospho-histone H3 (PHH3) protein expression, quantified by pathologists and automatically via deep learning. Additionally, an unsupervised deep learning algorithm was trained to uncover previously unnoticed morphological features with diagnostic value. Results: The accuracy in distinguishing typical from ACs is hampered by interobserver variability in mitotic counting and the limitations of morphological criteria in identifying aggressive cases. Our study reveals that different Ki-67 cut-offs can categorise LNETs similarly to current WHO criteria. Counting mitoses in PHH3+ areas does not improve diagnosis, while providing a similar prognostic value to the current criteria. With the advantage of being time efficient, automated assessment of these markers leads to similar conclusions. Lastly, state-of-the-art deep learning modelling does not uncover undisclosed morphological features with diagnostic value. Conclusions: This study suggests that the mitotic criteria can be complemented by manual or automated assessment of Ki-67 or PHH3 protein expression, but these markers do not significantly improve the prognostic value of the current classification, as the AC group remains highly unspecific for aggressive cases. Therefore, we may have exhausted the potential of morphological features in classifying and prognosticating LNETs. Our study suggests

Published
2024

4. PL03.07 Invasion or No Invasion, That’s the Question. A Large Reproducibility Study in Pulmonary Adenocarcinoma, Supporting a Modified Classification

Author

Thunnissen, E., primary, Blaauwgeers, H., additional, Filipello, F., additional, Lissenberg-Witte, B., additional, Minami, Y., additional, Noguchi, M., additional, Le Quense, J., additional, Papotti, M.G., additional, Flieder, D., additional, Pelosi, G., additional, Sansano, I., additional, Berezowska, S., additional, Ryška, A., additional, Brcic, L., additional, Motoi, N., additional, Nakatani, Y., additional, Kuempers, C., additional, Hofman, P., additional, Hofman, V., additional, Grotnes Dale, V., additional, Rossi, G., additional, Ambrosi, F., additional, Matsubara, D., additional, Ishikawa, Y., additional, Weynand, B., additional, Calabrese, F., additional, Pezzuto, F., additional, Kern, I., additional, Nicholson, S., additional, Mutka, A.-L., additional, Dacic, S., additional, Beasley, M.B., additional, Arrigoni, G., additional, Timens, W., additional, Ooft, M., additional, Brinkhuis, M., additional, Bulkmans, N., additional, Britstra, R., additional, Vreuls, W., additional, Jones, K., additional, von der Thüsen, J., additional, Hager, H., additional, Perner, S., additional, Moore, D., additional, Leonte, D.G., additional, Al-Janabi, S., additional, Schønau, A., additional, Stenzinger, A., additional, and Kazdal, D., additional

Published
2023
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6. Reference standards for gene fusion molecular assays on cytological samples: an international validation study

Author

Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, Troncone, Giancarlo, Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, and Troncone, Giancarlo

Abstract

AIMS: Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. METHODS: Cell lines harbouring EML4(13)-ALK(20) and SLC34A2(4)-ROS1(32) gene fusions were adopted to prepare reference standards. Eight laboratories (five adopting amplicon-based and three hybridisation-based platforms) received, at different dilution points two sets of slides (slide A 50.0%, slide B 25.0%, slide C 12.5% and slide D wild type) stained by Papanicolaou (Pap) and May Grunwald Giemsa (MGG). Analysis was carried out on a total of 64 slides. RESULTS: Four (50.0%) out of eight laboratories reported results on all slides and dilution points. While 12 (37.5%) out of 32 MGG slides were inadequate, 27 (84.4%) out of 32 Pap slides produced libraries adequate for variant calling. The laboratories using hybridisation-based platforms showed the highest rate of inadequate results (13/24 slides, 54.2%). Conversely, only 10.0% (4/40 slides) of inadequate results were reported by laboratories adopting amplicon-based platforms. CONCLUSIONS: Reference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches.

Published
2023

8. Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

Author

Alcala, N., Leblay, N., Gabriel, A. A. G., Mangiante, L., Hervas, D., Giffon, T., Sertier, A. S., Ferrari, A., Derks, J., Ghantous, A., Delhomme, T. M., Chabrier, A., Cuenin, C., Abedi-Ardekani, B., Boland, A., Olaso, R., Meyer, V., Altmuller, J., Le Calvez-Kelm, F., Durand, G., Voegele, C., Boyault, S., Moonen, L., Lemaitre, N., Lorimier, P., Toffart, A. C., Soltermann, A., Clement, J. H., Saenger, J., Field, J. K., Brevet, M., Blanc-Fournier, C., Galateau-Salle, F., Le Stang, N., Russell, P. A., Wright, G., Sozzi, G., Pastorino, U., Lacomme, S., Vignaud, J. M., Hofman, V., Hofman, P., Brustugun, O. T., Lund-Iversen, M., Thomas de Montpreville, V., Muscarella, L. A., Graziano, P., Popper, H., Stojsic, J., Deleuze, J. F., Herceg, Z., Viari, A., Nuernberg, P., Pelosi, G., Dingemans, A. M. C., Milione, M., Roz, L., Brcic, L., Volante, M., Papotti, M. G., Caux, C., Sandoval, J., Hernandez-Vargas, H., Brambilla, E., Speel, E. J. M., Girard, N., Lantuejoul, S., McKay, J. D., Foll, M., and Fernandez-Cuesta, L.

Published
2019
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9. Single-cell RNA-seq characterization of lung fibrosis resolution reveals a delayed capillary endothelial signature associated with alveolar regeneration in aged mice

Author

Truchi, M., primary, Savary, G., additional, Lebrigand, K., additional, Baeri, A., additional, Girard-Riboulleau, C., additional, Magnone, V., additional, Leroy, S., additional, Hofman, V., additional, Hofman, P., additional, Barbry, P., additional, Bellusci, S., additional, Cauffiez, C., additional, Vassaux, G., additional, Pottier, N., additional, and Mari, B., additional

Published
2023
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11. EP11.01-005 Ultra-Fast Gene Fusion Assessment as a Reflex Testing in Daily Clinical Practice for Advanced Non-small Cell Lung Cancer Patients

Author

Hofman, V., primary, Heeke, S., additional, Bontoux, C., additional, Chalabreysse, L., additional, Barritault, M., additional, Bringuier, P.P., additional, Fenouil, T., additional, Benzerdjeb, N., additional, Begueret, H., additional, Merlio, J.P., additional, Caumont, C., additional, Piton, N., additional, Sabourin, J.-C., additional, Evrard, S., additional, Syrykh, C., additional, Vigier, A., additional, Brousset, P., additional, Mazières, J., additional, Long-Mira, E., additional, Benzaquen, J., additional, Tanga, V., additional, Lespinet-Fabre, V., additional, Lassalle, S., additional, Marquette, C.-H., additional, Ilié, M., additional, and Hofman, P., additional

Published
2022
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12. EP11.01-006 Setting Up an Ultra-Fast Next-Generation Sequencing Approach as a Reflex Testing at Diagnosis in Non-squamous Non-small Cell Lung Cancer

Author

Bontoux, C., primary, Heeke, S., additional, Hofman, V., additional, Lespinet-Fabre, V., additional, Bordone, O., additional, Lassalle, S., additional, Long-Mira, E., additional, Lalvée, S., additional, Tanga, V., additional, Allegra, M., additional, Salah, M., additional, Benzaquen, J., additional, Marquette, C.-H., additional, Ilié, M., additional, and Hofman, P., additional

Published
2022
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13. Mésothéliome : les dispositifs en place en France « le réseau mésothéliome » 1998–2013

Author

Galateau-Sallé, Françoise, Gilg Soit Ilg, A., Le Stang, N., Brochard, P., Pairon, J.C., Astoul, P., Frenay, C., Blaizot, G., Chamming's, S., Ducamp, S., Rousvoal, T., de Quillacq, A., Abonnet, V., Abdalsamad, I., Begueret, H., Brambilla, E., Capron, F., Copin, M.C., Danel, C., de Lajartre, A.Y., Foulet-Roge, A., Garbe, L., Groussard, O., Giusiano, S., Hofman, V., Lantuejoul, S., Piquenot, J.M., Rouquette, I., Sagan, C., Thivolet-Bejui, F., Vignaud, J.M., Scherpereel, A., Jaurand, M.C., Jean, D., Hainaut, P., Chérié-Challine, L., Goldberg, M., Luce, D., and Imbernon, E.

Published
2014
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16. Creatividad y futuros en stop motion: aprendiendo a construir historias colaborativamente

Author

Història i Història de l'Art, Universitat Rovira i Virgili, Cornelio GS; Hofman V; Ardèvol E; Sivera S, Història i Història de l'Art, Universitat Rovira i Virgili, and Cornelio GS; Hofman V; Ardèvol E; Sivera S

Abstract

In this paper, we present the results of the workshops linked to the Future Story Chasers project, carried out in primary and secondary schools in Barcelona (Spain) with the aim of generating audiovisual narratives through them. These workshops, based on story generation through a board game and shaped through the stop motion technique, were produced in the context of a research project devoted to the creation of narrative tools and strategies that allow addressing social and environmental issues speculatively in education settings. We will analyze the materials generated by the participants in the workshops and the observation of the creative process and we will delve into two aspects: a) the creative strategies, improvisation or team management, b) the ways in which socio-environmental issues emerge as well as other significant issues related to the daily life of the participants and their symbolic universe.

Published
2022

32. Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method

Author

Hofman, V., Long, E., Ilie, M., Bonnetaud, C., Vignaud, J. M., Fléjou, J. F., Lantuejoul, S., Piaton, E., Mourad, N., Butori, C., Selva, E., Marquette, C. H., Poudenx, M., Sibon, S., Kelhef, S., Vénissac, N., Jais, J. P., Mouroux, J., Molina, T. J., Vielh, P., and Hofman, P.

Published
2012
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39. Integrating artificial intelligence into lung cancer screening: a randomised controlled trial protocol

Author

Paul Hofman, Sylvie Leroy, Jonathan Benzaquen, Bernard Padovani, Charles Hugo Marquette, Fontas Eric, Eric Fontas, Stephanie Lopez, Nesrine Rouis, Jacques Boutros, Allegra Maryline, Amamou-Elhani Faten, ARFI Thierry, Baque Jean, Baque-Juston Marie, Barel Remy, Barrios Baretto Deisy, Baudin Guillaume, Beck Camille, Bellmann Laurent, Benchetrit Maxime, Benkirane Mohamed-Taib, Benyoussef Sid Ali, Benzaquen Jonathan, Berthet Jean Philippe, Bonnard Eric, Bordone Olivier, Boutros Jacques, Boyer Guy-René, Bulsei Julie, Caillon Cynthia, Castelnau Olivier, Chalmin Jérémy, Chebib Ralph, Cohen Charlotte, Cruzel Coralie, Degoutte Aurélien, Delin Margot, Diascorn Yann, Doux Nathalie, Durand Lorraine, Duval Yannick, El Hemweh Omar, Fayada Julien, Felderhoof Eric, Feliciello Stéphane:, Femenia Richard, Ferrari Victoria, Francisci Marc Paul, Ghalloussi Hannah, Gomez-Caro-Andres Abel, Gora Assia, Griffonnet Jennifer, Gubeno Marie Christine, Guigay Joël, Hamila Marame, Harrathi Mohamed-Ali, Henaut Quentin, Herin Edouard, Hofman Paul, Hofman Véronique, ILIE Marius, Korzeniewski Sylvia, Lalvee Salomé, Lassalle Sandra, Le Heron Charles, Leray Loïc, Leriche Julien, Lerousseau Lionel, Leroy Sylvie, Lespinet Fabre Virginie, Lestrez Roxane, Leyssalle Axelle, Long Mira Elodie, Lopez Stephanie, Mahler Valentin, Maniel Charlotte, Marcano Xavier, Marco Roucayrol Sabine, Marquette Charles-Hugo, Martin Nicolas, Mistri Aurélie, Nicolle Isabelle, Novellas Sébastien, Oddo Frédéric, Otto Josiane, Padovani Bernard, PERQUIS Marie Pierre, Philibert Lorène, Pop Daniel, Pottier Héloïse, Raguin Olivier, Rolland Fabien, Rouis Nesrine, Rousset Johanna, Ruitort Frédéric, Sanfiorenzo Céline, Selva Eric, Tanga Virginie, Tardy Magalie, Thomas Olivier, Varenio Sophie, Verdoire Paul, Vigny Isabelle, Washetine Kévin, Zurlinden Olivier, Tarhini Adam, and Perrotin Cédric

Subjects
Medicine
Abstract

Introduction Lung cancer (LC) is the most common cause of cancer-related deaths worldwide. Its early detection can be achieved with a CT scan. Two large randomised trials proved the efficacy of low-dose CT (LDCT)-based lung cancer screening (LCS) in high-risk populations. The decrease in specific mortality is 20%–25%.Nonetheless, implementing LCS on a large scale faces obstacles due to the low number of thoracic radiologists and CT scans available for the eligible population and the high frequency of false-positive screening results and the long period of indeterminacy of nodules that can reach up to 24 months, which is a source of prolonged anxiety and multiple costly examinations with possible side effects.Deep learning, an artificial intelligence solution has shown promising results in retrospective trials detecting lung nodules and characterising them. However, until now no prospective studies have demonstrated their importance in a real-life setting.Methods and analysis This open-label randomised controlled study focuses on LCS for patients aged 50–80 years, who smoked more than 20 pack-years, whether active or quit smoking less than 15 years ago. Its objective is to determine whether assisting a multidisciplinary team (MDT) with a 3D convolutional network-based analysis of screening chest CT scans accelerates the definitive classification of nodules into malignant or benign. 2722 patients will be included with the aim to demonstrate a 3-month reduction in the delay between lung nodule detection and its definitive classification into benign or malignant.Ethics and dissemination The sponsor of this study is the University Hospital of Nice. The study was approved for France by the ethical committee CPP (Comités de Protection des Personnes) Sud-Ouest et outre-mer III (No. 2022-A01543-40) and the Agence Nationale du Medicament et des produits de Santé (Ministry of Health) in December 2023. The findings of the trial will be disseminated through peer-reviewed journals and national and international conference presentations.Trial registration number NCT05704920.

Published
2024
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41. Association of combined PD‐L1 expression and tumour‐infiltrating lymphocyte features with survival and treatment outcomes in patients with metastatic melanoma

Author

Bence, C., primary, Hofman, V., additional, Chamorey, E., additional, Long‐Mira, E., additional, Lassalle, S., additional, Albertini, A.F., additional, Liolios, I., additional, Zahaf, K., additional, Picard, A., additional, Montaudié, H., additional, Lacour, J.P., additional, Passeron, T., additional, Andea, A.A., additional, Ilie, M., additional, and Hofman, P., additional

Published
2019
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42. P2.09-17 Real-World Concordance Across Pathologists for PD-L1 Scoring in Non-Small Cell Lung Cancer: Results from a Large Nationwide Initiative

Author

Adam, J., primary, Hofman, V., additional, Mansuet-Lupo, A., additional, Rouquette, I., additional, Vignaud, J., additional, Badoual, C., additional, Bégueret, H., additional, Copin, M., additional, Damotte, D., additional, Danel, C., additional, Forest, F., additional, Garcia, S., additional, Gibault, L., additional, Penault-Llorca, F., additional, Lantuejoul, S., additional, Cazes, A., additional, and Le Stang, N., additional

Published
2019
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44. Efficacité et tolérance du mébutate d’ingénol dans le mélanome de Dubreuilh in situ de la face : étude pilote, de phase II prospective et multicentrique indiquant aucun bénéfice

Author

Montaudié, H., primary, Le Duff, F., additional, Butori, C., additional, Hofman, V., additional, Fontas, E., additional, Roger, C., additional, Perrot, J.-L., additional, Desmedt, E., additional, Legoupil, D., additional, Passeron, T., additional, and Lacour, J.-P., additional

Published
2018
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45. Association of combined PD‐L1 expression and tumour‐infiltrating lymphocyte features with survival and treatment outcomes in patients with metastatic melanoma.

Author

Bence, C., Hofman, V., Chamorey, E., Long‐Mira, E., Lassalle, S., Albertini, A.F., Liolios, I., Zahaf, K., Picard, A., Montaudié, H., Lacour, J.P., Passeron, T., Andea, A.A., Ilie, M., and Hofman, P.

Subjects
*PROGRAMMED death-ligand 1, *IMMUNE checkpoint inhibitors, *TREATMENT effectiveness, *T cells, *LYMPHOCYTES, *MELANOMA, *UVEA cancer
Abstract

Background: Recent advances obtained with immune checkpoint inhibitors (ICIs) targeting the programmed cell death‐1 (PD‐1) protein have significantly improved the outcome of patients with metastatic melanoma. The PD‐L1 expression in tumour cells as detected by immunohistochemistry is a predictive biomarker in some solid tumours, but appears insufficient as prognostic or predictive factor of response to ICIs in metastatic melanomas. Objectives: We investigated whether the presence and the features of pretreatment CD8+tumour‐infiltrating T lymphocytes (TILs) could be a complementary prognostic or predictive biomarker in patients with metastatic melanoma. Methods: In this retrospective study, we evaluated the association of PD‐L1 expression ≥5% of tumour cells combined with TIL features (CD8, CD28, Ki67) with the overall survival (OS) among 51 patients treated with ICIs and 54 patients treated with other treatment options (non‐ICIs). Results: PD‐L1 positivity was observed in 33% and 39% of primary melanomas and matched metastases, respectively, with, however, poor concordance between the primary and the matched metastatic site (κ = 0.283). No significant association was noted between PD‐L1 expression and CD8+TIL profile analysed as single markers and OS or response to immunotherapy. Instead, their combined analysis in primary melanoma samples showed that the PD‐L1−/CD8+status was significantly associated with prolonged OS in the whole population (P = 0.04) and in the subgroup treated with non‐ICIs (P = 0.009). Conversely, the PD‐L1+/CD8+ status was a good prognostic factor in patients treated with ICIs (P = 0.022), whereas was significantly associated with poor prognosis in patients treated with non‐ICIs (P = 0.014). While the expression of CD28 was not related to outcome, the Ki67 expression was significantly associated with poor OS in the subgroup CD8+TIL+/PD‐L1− (P = 0.02). Conclusions: The pretreatment combination of PD‐L1 expression with the level of CD8+TILs could better assess OS and predict therapeutic response of patients with metastatic melanoma treated by either immunotherapy or other treatment regimens. [ABSTRACT FROM AUTHOR]

Published
2020
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46. New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center

Author

Galateau Salle, F., primary, Le Stang, N., additional, Nicholson, A.G., additional, Pissaloux, D., additional, Churg, A., additional, Klebe, S., additional, Roggli, V.L., additional, Tazelaar, H.D., additional, Vignaud, J.M., additional, Attanoos, R., additional, Beasley, M.B., additional, Begueret, H., additional, Capron, F., additional, Chirieac, L., additional, Copin, M.C., additional, Dacic, S., additional, Danel, C., additional, Foulet-Roge, A., additional, Gibbs, A., additional, Giusiano-Courcambeck, S., additional, Hiroshima, K., additional, Hofman, V., additional, Husain, A.N., additional, Kerr, K., additional, Marchevsky, A., additional, Nabeshima, K., additional, Picquenot, J.M., additional, Rouquette, I., additional, Sagan, C., additional, Sauter, J.L., additional, Thivolet, F., additional, Travis, W.D., additional, Tsao, M.S., additional, Weynand, B., additional, Damiola, F., additional, Scherpereel, A., additional, Pairon, J.C., additional, Lantuejoul, S., additional, Rusch, V., additional, and Girard, N., additional

Published
2018
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50. Étude pilote de l’effet de la metformine dans le mélanome avancé

Author

Montaudié, H., primary, Cerezo, M., additional, Bahadoran, P., additional, Passeron, T., additional, Lehraiki, A., additional, Machet, L., additional, Arnault, J.-P., additional, Verneuil, L., additional, Maubec, E., additional, Aubin, F., additional, Granel, F., additional, Leccia, M.-T., additional, Lebbé, C., additional, Saiag, P., additional, Beylot-Barry, M., additional, Mansard, S., additional, Mortier, L., additional, Wierzbicka-Hainaut, E., additional, Giacchero, D., additional, Hofman, V., additional, Lacour, J.-P., additional, Balotti, R., additional, and Rocchi, S., additional

Published
2016
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