2,168 results on '"Hoffmann, A. L."'
Search Results
2. The age of hand stencils in Maltravieso cave (Extremadura, Spain) established by U-Th dating, and its implications for the early development of art
- Author
-
Standish, Christopher D., Pettitt, Paul, Collado, Hipolito, Aguilar, Juan Carlos, Milton, J. Andy, García-Diez, Marcos, Hoffmann, Dirk L., Zilhão, João, and Pike, Alistair W.G.
- Published
- 2025
- Full Text
- View/download PDF
3. Absolute Calibration of Cepheid Period-Luminosity Relations in NGC 4258
- Author
-
Yuan, Wenlong, Macri, Lucas M., Riess, Adam G., Brink, Thomas G., Casertano, Stefano, Filippenko, Alexei V., Hoffmann, Samantha L., Huang, Caroline D., and Scolnic, Dan
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
NGC 4258 is one of the most important anchors for calibrating the Cepheid period--luminosity relations (PLRs) owing to its accurate distance measured from water maser motions. We expand on previous efforts and carry out a new Cepheid search in this system using the Hubble Space Telescope (HST). We discover and measure a sample of 669 Cepheids in four new and two archival NGC 4258 fields, doubling the number of known Cepheids in this galaxy and obtaining an absolute calibration of their optical PLRs. We determine a Wesenheit PLR of $-2.574(\pm0.034) -3.294(\pm0.042) \log P$, consistent with an independent Large Magellanic Cloud (LMC) calibration at the level of $0.032\pm0.044$~mag in its zeropoint, after accounting for a metallicity dependence of $-0.20\pm0.05$~mag\,dex$^{-1}$ (Riess et al. 2006). Our determination of the PLR slope also agrees with the LMC-based value within their uncertainties. We attempt to characterize the metallicity effect of Cepheid PLRs using only the NGC 4258 sample, but a relatively narrow span of abundances limits our sensitivity and yields a Wesenheit zero-point dependence of $-0.07 \pm 0.21$ mag\,dex$^{-1}$. The Cepheid measurements presented in this study have been used as part of the data to derive the Hubble constant in a companion paper by the SH0ES team., Comment: Accepted to ApJ. 13 pages, 8 figures
- Published
- 2022
- Full Text
- View/download PDF
4. Pharmacokinetics of grapiprant and effects on TNF‐alpha concentrations following oral administration to horses
- Author
-
Hoffmann, Silke L, Seminoff, Kelsey, McKemie, Daniel S, Kass, Philip H, and Knych, Heather K
- Subjects
Veterinary Sciences ,Agricultural ,Veterinary and Food Sciences ,Biodefense ,Prevention ,Vaccine Related ,Administration ,Oral ,Animals ,Area Under Curve ,Half-Life ,Horses ,Imidazoles ,Prostaglandins E ,Pyridines ,Sulfonylurea Compounds ,Tumor Necrosis Factor-alpha ,grapiprant ,horse ,NSAID ,pharmacokinetics ,TNF alpha ,Veterinary sciences - Abstract
Grapiprant is a prostaglandin E2 receptor antagonist that has been found to be an effective anti-inflammatory in dogs and that is devoid of some of the adverse effects associated with traditional NSAIDs that elicit their effects through inhibition of PGE2 production. Previously published reports have described the pharmacokinetics of this drug in horses when administered at 2 mg/kg; however, pharmacodynamic effects in this species have yet to be described. The objective of the current study was to describe the pharmacokinetics and pharmacodynamics of grapiprant at a higher dose. Eight horses received a single oral administration of 15 mg/kg. Plasma concentrations were determined for 96 h using liquid chromatography-tandem mass spectrometry. Non-compartmental analysis was used to determine pharmacokinetic parameters. Pharmacodynamic effects were assessed ex vivo by stimulating blood samples with PGE2 and determining TNF-ɑ concentrations. Maximum concentration, time to maximum concentration and area under the curve were 327.5 (188.4-663.0) ng/ml, 1 (0.75-2.0) hour and 831.8 (512.6-1421.6) h*ng/ml, respectively. The terminal half-life was 11.1 (8.27-21.2) hr. Significant stimulation of TNF alpha was noted for 2-4 h post-drug administration. Results of this study suggest a short duration of EP4 receptor engagement when administered at a dose of 15 mg/kg.
- Published
- 2022
5. Prediction of radiation pneumonitis using the effective α/β of lungs and heart in NSCLC patients treated with proton beam therapy
- Author
-
Weiß, Albrecht, Löck, Steffen, Xu, Ting, Liao, Zhongxing, Hoffmann, Aswin L., and Troost, Esther G.C.
- Published
- 2024
- Full Text
- View/download PDF
6. The Cepheid Distance to the Narrow-Line Seyfert 1 Galaxy NGC 4051
- Author
-
Yuan, Wenlong, Macri, Lucas M., Peterson, Bradley M., Riess, Adam G., Fausnaugh, Michael M., Hoffmann, Samantha L., Anand, Gagandeep S., Bentz, Misty C., Bontà, Elena Dalla, Davies, Richard I., de Rosa, Gisella, Ferrarese, Laura, Grier, Catherine J., Hicks, Erin K. S., Onken, Christopher A., Pogge, Richard W., Storchi-Bergmann, Thaisa, and Vestergaard, Marianne
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We derive a distance of $D = 16.6 \pm 0.3$~Mpc ($\mu=31.10\pm0.04$~mag) to the archetypal narrow-line Seyfert 1 galaxy NGC 4051 based on Cepheid Period--Luminosity relations and new Hubble Space Telescope multiband imaging. We identify 419 Cepheid candidates and estimate the distance at both optical and near-infrared wavelengths using subsamples of precisely-photometered variables (123 and 47 in the optical and near-infrared subsamples, respectively). We compare our independent photometric procedures and distance-estimation methods to those used by the SH0ES team and find agreement to 0.01~mag. The distance we obtain suggests an Eddington ratio $\dot{m} \approx 0.2$ for NGC 4051, typical of narrow-line Seyfert 1 galaxies, unlike the seemingly-odd value implied by previous distance estimates. We derive a peculiar velocity of $-490\pm34$~km~s$^{-1}$ for NGC 4051, consistent with the overall motion of the Ursa Major Cluster in which it resides. We also revisit the energetics of the NGC 4051 nucleus, including its outflow and mass accretion rates., Comment: 15 pages, 12 figures, 6 tables, accepted for publication in ApJ
- Published
- 2020
- Full Text
- View/download PDF
7. The Cepheid Distance to the Seyfert 1 Galaxy NGC 4151
- Author
-
Yuan, Wenlong, Fausnaugh, Michael M., Hoffmann, Samantha L., Macri, Lucas M., Peterson, Bradley M., Riess, Adam G., Bentz, Misty C., Brown, Jonathan S., Bontà, Elena Dalla, Davies, Richard I., de Rosa, Gisella, Ferrarese, Laura, Grier, Catherine J., Hicks, Erin K. S., Onken, Christopher A., Pogge, Richard W., Storchi-Bergmann, Thaisa, and Vestergaard, Marianne
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We derive a distance of $15.8\pm0.4$ Mpc to the archetypical Seyfert 1 galaxy NGC 4151 based on the near-infrared Cepheid Period-Luminosity relation and new Hubble Space Telescope multiband imaging. This distance determination, based on measurements of 35 long-period ($P > 25$d) Cepheids, will support the absolute calibration of the supermassive black hole mass in this system, as well as studies of the dynamics of the feedback or feeding of its active galactic nucleus., Comment: 18 pages. 11 figures. 7 tables. Accepted for publication in ApJ
- Published
- 2020
- Full Text
- View/download PDF
8. Hubble Space Telescope Observations of Mira Variables in the Type Ia Supernova Host NGC 1559: An Alternative Candle to Measure the Hubble Constant
- Author
-
Huang, Caroline D., Riess, Adam G., Yuan, Wenlong, Macri, Lucas M., Zakamska, Nadia L., Casertano, Stefano, Whitelock, Patricia A., Hoffmann, Samantha L., Filippenko, Alexei V., and Scolnic, Daniel
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present year-long, near-infrared Hubble Space Telescope WFC3 observations used to search for Mira variables in NGC 1559, the host galaxy of the Type Ia supernova (SN Ia) 2005df. This is the first dedicated search for Miras, highly-evolved low-mass stars, in a SN Ia host and subsequently the first calibration of the SN Ia luminosity using Miras in a role historically played by Cepheids. We identify a sample of 115 O-rich Miras with P < 400 days based on their light curve properties. We find that the scatter in the Mira Period-Luminosity Relation (PLR) is comparable to Cepheid PLRs seen in SN Ia supernova host galaxies. Using a sample of O-rich Miras discovered in NGC 4258 with HST F160W and its maser distance, we measure a distance modulus for NGC 1559 of mu1559 = 31.41 +/- 0.050 (statistical) +/- 0.060 (systematic) mag. Based on the light curve of the normal, well-observed, low-reddening SN 2005df, we obtain a measurement of the fiducial SN Ia absolute magnitude of MB0 = -19.27 +/- 0.13 mag. With the Hubble diagram of SNe Ia we find H0 = 72.7 +/- 4.6 kms-1 Mpc-1. Combining the calibration from the NGC 4258 megamaser and the Large Magellanic Cloud detached eclipsing binaries gives a best value of H0 = 73.3 +/- 4.0 km s-1 Mpc-1. This result is within 1-sigma of the Hubble constant derived using Cepheids and multiple calibrating SNe Ia. This is the first of four expected calibrations of the SN Ia luminosity from Miras which should reduce the error in H0 via Miras to ~3%. In light of the present Hubble tension and JWST, Miras have utility in the extragalactic distance scale to check Cepheid distances or calibrate nearby SNe in early-type host galaxies that would be unlikely targets for Cepheid searches., Comment: 15 pages, 11 figures, ApJ in press
- Published
- 2019
- Full Text
- View/download PDF
9. Reduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI
- Author
-
Schneider, Sergej, Stefanowicz, Sarah, Jentsch, Christina, Lohaus, Fabian, Thiele, Julia, Haak, Danilo, Valentini, Chiara, Platzek, Ivan, G. C. Troost, Esther, and Hoffmann, Aswin L.
- Published
- 2023
- Full Text
- View/download PDF
10. Numerical Models for the Diffuse Ionized Gas in Galaxies. II. Three-dimensional radiative transfer in inhomogeneous interstellar structures as a tool for analyzing the diffuse ionized gas
- Author
-
Weber, J. A., Pauldrach, A. W. A., and Hoffmann, T. L.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims: We systematically explore a plausible subset of the parameter space involving effective temperatures and metallicities of the ionizing stellar sources, the effects of the hardening of their radiation by surrounding leaky HII regions with different escape fractions, as well as different scenarios for the clumpiness of the DIG, and compute the resulting line strength ratios for a number of diagnostic optical emission lines. Methods: For the ionizing fluxes we compute a grid of stellar spectral energy distributions (SEDs) from detailed, fully non-LTE model atmospheres that include the effects of stellar winds and line blocking and blanketing. To calculate the ionization and temperature structure in the HII regions and the diffuse ionized gas we use spherically symmetric photoionization models as well as state-of-the-art three-dimensional (3D) non-LTE radiative transfer simulations, considering hydrogen, helium, and the most abundant metals. Results: We provide quantitative predictions of how the line ratios from HII regions and the DIG vary as a function of metallicity, stellar effective temperature, and escape fraction from the HII region. The range of predicted line ratios reinforces the hypothesis that the DIG is ionized by (filtered) radiation from hot stars; however, comparison of observed and predicted line ratios indicates that the DIG is typically ionized with a softer SED than predicted by the chosen stellar population synthesis model. Even small changes in simulation parameters like the clumping factor can lead to considerable variation in the ionized volume. Both for a more homogeneous gas and a very inhomogeneous gas containing both dense clumps and channels with low gas density, the ionized region in the dilute gas above the galactic plane can cease to be radiation-bounded, allowing the ionizing radiation to leak into the intergalactic medium., Comment: 21 pages, 9 figures, accepted by A&A
- Published
- 2018
- Full Text
- View/download PDF
11. The Outer Stellar Halos of Galaxies: how Radial Merger Mass Deposition, Shells and Streams depend on Infall-Orbit Configurations
- Author
-
Karademir, Geray S., Remus, Rhea-Silvia, Burkert, Andreas, Dolag, Klaus, Hoffmann, Tadziu L., Moster, Benjamin P., Steinwandel, Ulrich, and Zhang, Jielai
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Galaxy mergers are a fundamental part of galaxy evolution. To study the resulting mass distributions of different kinds of galaxy mergers, we present a simulation suite of 36 high-resolution isolated merger simulations, exploring a wide range of parameter space in terms of mass ratios (mu = 1:5, 1:10, 1:50, 1:100) and orbital parameters. We find that mini mergers deposit a higher fraction of their mass in the outer halo compared to minor mergers, while their contribution to the central mass distribution is highly dependent on the orbital impact parameter: for larger pericentric distances we find that the centre of the host galaxy is almost not contaminated by merger particles. We also find that the median of the resulting radial mass distribution for mini mergers differs significantly from the predictions of simple theoretical tidal-force models. Furthermore, we find that mini mergers can increase the size of the host disc significantly without changing the global shape of the galaxy, if the impact occurs in the disc plane, thus providing a possible explanation for extended low-surface brightness disks reported in observations. Finally, we find clear evidence that streams are a strong indication of nearly circular infall of a satellite (with large angular momentum), whereas the appearance of shells clearly points to (nearly) radial satellite infall., Comment: 17 pages, 15 figures, published by MNRAS doi: 10.1093/mnras/stz1251
- Published
- 2018
- Full Text
- View/download PDF
12. Significant Luminosity Differences of Two Twin Type Ia Supernovae
- Author
-
Foley, Ryan J., Hoffmann, Samantha L., Macri, Lucas M., Riess, Adam G., Brown, Peter J., Filippenko, Alexei V., Graham, Melissa L., and Milne, Peter A.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Type Ia supernovae (SNe Ia) 2011by, hosted in NGC 3972, and 2011fe, hosted in M101, are optical "twins," having almost identical optical light-curve shapes, colours, and near-maximum-brightness spectra. However, SN 2011fe had significantly more ultraviolet (UV; 1600 < lambda < 2500 A) flux than SN 2011by before and at peak luminosity. Theory suggests that SNe Ia with higher progenitor metallicity should (1) have additional UV opacity near peak and thus lower UV flux; (2) have an essentially unchanged optical spectral-energy distribution; (3) have a similar optical light-curve shape; and (4) because of the excess neutrons, produce more stable Fe-group elements at the expense of radioactive 56Ni and thus have a lower peak luminosity. Foley & Kirshner (2013) suggested that the difference in UV flux between SNe 2011by and 2011fe was the result of their progenitors having significantly different metallicities. The SNe also had a large, but insignificant, difference between their peak absolute magnitudes (Delta M_V, peak = 0.60 +/- 0.36 mag), with SN 2011fe being more luminous. We present a new Cepheid-based distance to NGC 3972, significantly improving the precision of the distance measurement for SN 2011by. With these new data, we determine that the SNe have significantly different peak luminosities (Delta M_V, peak = 0.335 +/- 0.069 mag), corresponding to SN 2011fe having produced 38% more 56Ni than SN 2011by, and providing additional evidence for progenitor metallicity differences for these SNe. We discuss how progenitor metallicity differences can contribute to the intrinsic scatter for light-curve-shape-corrected SN luminosities, the use of "twin" SNe for measuring distances, and implications for using SNe Ia for constraining cosmological parameters., Comment: 10 pages, 6 figures, submitted to MNRAS
- Published
- 2018
- Full Text
- View/download PDF
13. A Near-Infrared Period-Luminosity Relation for Miras in NGC 4258, an Anchor for a New Distance Ladder
- Author
-
Huang, Caroline D., Riess, Adam G., Hoffmann, Samantha L., Klein, Christopher, Bloom, Joshua, Yuan, Wenlong, Macri, Lucas M., Jones, David O., Whitelock, Patricia A., Casertano, Stefano, and Anderson, Richard I.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present year-long, near-infrared Hubble Space Telescope WFC3 observations of Mira variables in the water megamaser host galaxy NGC 4258. Miras are AGB variables that can be divided into oxygen- (O-) and carbon- (C-) rich subclasses. Oxygen-rich Miras follow a tight (scatter $\sim 0.14$ mag) Period-Luminosity Relation (PLR) in the near-infrared and can be used to measure extragalactic distances. The water megamaser in NGC 4258 gives a geometric distance to the galaxy accurate to 2.6% that can serve to calibrate the Mira PLR. We develop criteria for detecting and classifying O-rich Miras with optical and NIR data as well as NIR data alone. In total, we discover 438 Mira candidates that we classify with high confidence as O-rich. Our most stringent criteria produce a sample of 139 Mira candidates that we use to measure a PLR. We use the OGLE-III sample of O-rich Miras in the LMC to obtain a relative distance modulus, $\mu_{4258} - \mu_{LMC} = 10.95 \pm 0.01 $ (statistical) $\pm 0.06 $ (systematic) mag in good agreement with the relative distance determined using Cepheids. These results demonstrate the feasibility of discovering and characterizing Miras using the near-infrared with the Hubble Space Telescope and the upcoming James Webb Space Telescope and using them to measure extragalactic distances and determine the Hubble constant., Comment: 19 pages, 19 figures
- Published
- 2018
- Full Text
- View/download PDF
14. EMPIRICALLY ESTIMATING CARRYING CAPACITY FOR JUVENILE CHINOOK SALMON
- Author
-
See, Kevin E., Ackerman, Michael W., Carmichael, Richard A., Hoffmann, Sarah L., and Beasley, Chris
- Published
- 2021
15. The Outer Halos of Very Massive Galaxies: BCGs and their DSC in the Magneticum Simulations
- Author
-
Remus, Rhea-Silvia, Dolag, Klaus, and Hoffmann, Tadziu L.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Recent hydrodynamic cosmological simulations cover volumes up to Gpc^3 and resolve halos across a wide range of masses and environments, from massive galaxy clusters down to normal galaxies, while following a large variety of physical processes (star formation, chemical enrichment, AGN feedback) to allow a self-consistent comparison to observations at multiple wavelengths. Using the Magneticum simulations, we investigate the buildup of the diffuse stellar component (DSC) around massive galaxies within group and cluster environments. The DSC in our simulations reproduces the spatial distribution of the observed intracluster light (ICL) as well as its kinematic properties remarkably well. For galaxy clusters and groups we find that, although the DSC in almost all cases shows a clear separation from the brightest cluster galaxy (BCG) with regard to its dynamic state, the radial stellar density distribution in many halos is often characterized by a single Sersic profile, representing both the BCG component and the DSC, very much in agreement with current observational results. Interestingly, even in those halos that clearly show two components in both the dynamics and the spatial distribution of the stellar component, no correlation between them is evident., Comment: 14 pages, 8 figures, published in Galaxies
- Published
- 2017
- Full Text
- View/download PDF
16. Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams
- Author
-
Schellhammer, Sonja M, Gantz, Sebastian, Lühr, Armin, Oborn, Bradley M, Bussmann, Michael, and Hoffmann, Aswin L
- Subjects
Physics - Medical Physics ,Physics - Applied Physics - Abstract
Given the sensitivity of proton therapy to anatomical variations, this cancer treatment modality is expected to benefit greatly from integration with magnetic resonance (MR) imaging. One of the obstacles hindering such an integration are strong magnetic field induced dose distortions. These have been predicted in simulation studies, but no experimental validation has been performed so far. Here we show the first measurement of planar distributions of dose deposited by therapeutic proton pencil beams traversing a one-Tesla transversal magnetic field while depositing energy in a tissue-like phantom using film dosimetry. The lateral beam deflection ranges from one millimeter to one centimeter for 80 to 180 MeV beams. Simulated and measured deflection agree within one millimeter for all studied energies. These results proof that the magnetic field induced proton beam deflection is both measurable and accurately predictable. This demonstrates the feasibility of accurate dose measurement and hence validates dose predictions for the framework of MR-integrated proton therapy.
- Published
- 2017
- Full Text
- View/download PDF
17. Carbon line formation and spectroscopy in O-type stars
- Author
-
Carneiro, Luiz P., Puls, J., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
The determination of chemical abundances constitutes a fundamental requirement for obtaining a complete picture of a star. Particularly in massive stars, CNO abundances are of prime interest, due to the nuclear CNO-cycle and various mixing processes which bring these elements to the surface. We aim at enabling a reliable carbon spectroscopy for our unified NLTE atmosphere code FASTWIND. We develop a new carbon model atom including CII/III/IV/V, and discuss problems related to carbon spectroscopy in O-type stars. We describe different tests to examine the reliability of our implementation, and investigate which mechanisms influence the carbon ionization balance. By comparing with high-resolution spectra from six O-type stars, we check in how far observational constraints can be reproduced by our new carbon line synthesis. Carbon lines are even more sensitive to a variation of temperature, gravity, and mass-loss rate, than hydrogen/helium lines. We are able to reproduce most of the observed lines from our stellar sample, and to estimate those specific carbon abundances which bring the lines from different ions into agreement. For hot dwarfs and supergiants earlier than O7, X-rays from wind-embedded shocks can impact the synthesized line strengths, particularly for CIV, potentially affecting the abundance determination. We have demonstrated our capability to derive realistic carbon abundances by means of FASTWIND, using our recently developed model atom. We found that complex effects can have a strong influence on the carbon ionization balance in hot stars. For a further understanding, the UV range needs to be explored as well. By means of detailed nitrogen and oxygen model atoms available to use, we will be able to perform a complete CNO abundance analysis for larger samples of massive stars, and to provide constraints on corresponding evolutionary models and aspects., Comment: 22 pages, 16 figures, 6 tables
- Published
- 2017
- Full Text
- View/download PDF
18. Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4 + T Cells of an Autoimmune Uveitis Model.
- Author
-
Söth, Ronja, Hoffmann, Anne L. C., and Deeg, Cornelia A.
- Subjects
- *
OXIDATION of glucose , *REACTIVE oxygen species , *FUEL switching , *ALTERNATIVE fuels , *OXYGEN consumption , *T cells - Abstract
Equine recurrent uveitis (ERU) is a spontaneously occurring autoimmune disease and one of the leading causes of blindness in horses worldwide. Its similarities to autoimmune-mediated uveitis in humans make it a unique spontaneous animal model for this disease. Although many aspects of ERU pathogenesis have been elucidated, it remains not fully understood and requires further research. CD4+ T cells have been a particular focus of research. In a previous study, we showed metabolic alterations in CD4+ T cells from ERU cases, including an increased basal oxygen consumption rate (OCR) and elevated compensatory glycolysis. To further investigate the underlying reasons for and consequences of these metabolic changes, we quantified reactive oxygen species (ROS) production in CD4+ T cells from ERU cases and compared it to healthy controls, revealing significantly higher ROS production in ERU-affected horses. Additionally, we aimed to define mitochondrial fuel oxidation of glucose, glutamine, and long-chain fatty acids (LCFAs) and identified significant differences between CD4+ T cells from ERU cases and controls. CD4+ T cells from ERU cases showed a lower dependency on mitochondrial glucose oxidation and greater metabolic flexibility for the mitochondrial oxidation of glucose and LCFAs, indicating an enhanced ability to switch to alternative fuels when necessary. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Tumor-Promoted Changes in Pediatric Brain Histology Can Be Distinguished from Normal Parenchyma by Desorption Electrospray Ionization Mass Spectrometry Imaging.
- Author
-
Seidinger, Ana L., Silva, Felipe L. T., Euzébio, Mayara F., Krieger, Anna C., Meidanis, João, Gutierrez, Junier M., Bezerra, Thais M. S., Queiroz, Luciano, Silva, Alex A. Rosini., Hoffmann, Iva L., Daiggi, Camila M. M., Tedeschi, Helder, Eberlin, Marcos N., Eberlin, Livia S., Yunes, José A., Porcari, Andreia M., and Cardinalli, Izilda A.
- Subjects
DESORPTION ionization mass spectrometry ,ELECTROSPRAY ionization mass spectrometry ,DESORPTION electrospray ionization ,SURGICAL equipment ,CENTRAL nervous system ,BRAIN tumors - Abstract
Background: Central nervous system (CNS) tumors are the second most frequent type of neoplasm in childhood and adolescence, after leukemia. Despite the incorporation of molecular classification and improvement of protocols combining chemotherapy, surgery, and radiotherapy, CNS tumors are still the most lethal neoplasm in this age group. Mass spectrometry imaging (MSI) is a powerful tool to map the distribution of molecular species in tissue sections. Among MSI techniques, desorption electrospray ionization (DESI-MSI) has been demonstrated to enable reliable agreement with the pathological evaluation of different adult cancer types, along with an acceptable time scale for intraoperative use. Methods: In the present work, we aimed to investigate the chemical profile obtained by DESI-MSI as an intraoperative surgical management tool by profiling 162 pediatric brain biopsies and reporting the results according to the histopathology and molecular profile of the tumors. Results: The 2D chemical images obtained by DESI-MSI allowed us to distinguish tumor-transformed tissue from non-tumor tissue with an accuracy of 96.8% in the training set and 94.3% in the validation set after statistical modeling of our data using Lasso. In addition, high-grade and low-grade tumors also displayed a distinct chemical profile when analyzed by DESI-MSI. We also provided evidence that the chemical profile of brain tumors obtained by DESI-MSI correlates with methylation-based molecular classes and specific immunophenotypes found in brain biopsies. Conclusions: The results presented herein support the incorporation of DESI-MSI analysis as an intraoperative assistive tool in prospective clinical trials for pediatric brain tumors management in the near future. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. EXAMINING THE PAST, PRESENT, AND FUTURE OF AN ICONIC MOJAVE DESERT SPECIES, THE JOSHUA TREE ( YUCCA BREVIFOLIA, YUCCA JAEGERIANA )
- Author
-
Wilkening, Jennifer L., Hoffmann, Scott L., and Sirchia, Felicia
- Published
- 2020
21. Optical Identification of Cepheids in 19 Host Galaxies of Type Ia Supernovae and NGC 4258 with the Hubble Space Telescope
- Author
-
Hoffmann, Samantha L., Macri, Lucas M., Riess, Adam G., Yuan, Wenlong, Casertano, Stefano, Foley, Ryan J., Filippenko, Alexei V., Tucker, Brad E., Chornock, Ryan, Silverman, Jeffrey M., Welch, Douglas L., Goobar, Ariel, and Amanullah, Rahman
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present results of an optical search for Cepheid variable stars using the Hubble Space Telescope (HST) in 19 hosts of Type Ia supernovae (SNe Ia) and the maser-host galaxy NGC 4258, conducted as part of the SH0ES project (Supernovae and H0 for the Equation of State of dark energy). The targets include 9 newly imaged SN Ia hosts using a novel strategy based on a long-pass filter that minimizes the number of HST orbits required to detect and accurately determine Cepheid properties. We carried out a homogeneous reduction and analysis of all observations, including new universal variability searches in all SN Ia hosts, that yielded a total of 2200 variables with well-defined selection criteria -- the largest such sample identified outside the Local Group. These objects are used in a companion paper to determine the local value of H0 with a total uncertainty of 2.4%., Comment: ApJ, in press. v2 adds missing co-author to arXiv metadata and text in acknowledgments
- Published
- 2016
- Full Text
- View/download PDF
22. A 2.4% Determination of the Local Value of the Hubble Constant
- Author
-
Riess, Adam G., Macri, Lucas M., Hoffmann, Samantha L., Scolnic, Dan, Casertano, Stefano, Filippenko, Alexei V., Tucker, Brad E., Reid, Mark J., Jones, David O., Silverman, Jeffrey M., Chornock, Ryan, Challis, Peter, Yuan, Wenlong, Brown, Peter J., and Foley, Ryan J.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We use the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) to reduce the uncertainty in the local value of the Hubble constant (H_0) from 3.3% to 2.4%. Improvements come from new, near-infrared observations of Cepheid variables in 11 new hosts of recent SNe~Ia, more than doubling the sample of SNe~Ia having a Cepheid-calibrated distance for a total of 19; these leverage the magnitude-z relation based on 300 SNe~Ia at z<0.15. All 19 hosts and the megamaser system NGC4258 were observed with WFC3, thus nullifying cross-instrument zeropoint errors. Other improvements include a 33% reduction in the systematic uncertainty in the maser distance to NGC4258, more Cepheids and a more robust distance to the LMC from late-type DEBs, HST observations of Cepheids in M31, and new HST-based trigonometric parallaxes for Milky Way (MW) Cepheids. We consider four geometric distance calibrations of Cepheids: (i) megamasers in NGC4258, (ii) 8 DEBs in the LMC, (iii) 15 MW Cepheids with parallaxes, and (iv) 2 DEBs in M31. H_0 from each is 72.25+/-2.51, 72.04+/-2.67, 76.18+/-2.37, and 74.50+/-3.27 km/sec/Mpc, respectively. Our best estimate of 73.24+/-1.74 km/sec/Mpc combines the anchors NGC4258, MW, and LMC, and includes systematic errors for a final uncertainty of 2.4%. This value is 3.4 sigma higher than 66.93+/-0.62 km/sec/Mpc predicted by LambdaCDM with 3 neutrinos with mass 0.06 eV and the Planck data, but reduces to 2.1 sigma relative to the prediction of 69.3+/-0.7 km/sec/Mpc with the combination of WMAP+ACT+SPT+BAO, suggesting systematic uncertainties in CMB measurements may play a role in the tension. If we take the conflict between Planck and H_0 at face value, one plausible explanation could involve an additional source of dark radiation in the early Universe in the range of Delta N_eff=0.4-1. We anticipate significant improvements in H_0 from upcoming parallax measurements., Comment: accepted ApJ, includes proof corrections and edits, 63 pages, 16 figures, 8 tables. Table 4 available electronically by ApJ Revised since v1 to include one new supernova/calibrator and updated Planck constraints
- Published
- 2016
- Full Text
- View/download PDF
23. The Co-Evolution of Total Density Profiles and Central Dark Matter Fractions in Simulated Early-Type Galaxies
- Author
-
Remus, Rhea-Silvia, Dolag, Klaus, Naab, Thorsten, Burkert, Andreas, Hirschmann, Michaela, Hoffmann, Tadziu L., and Johansson, Peter H.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present evidence from cosmological hydrodynamical simulations for a co-evolution of the slope of the total (dark and stellar) mass density profile, gamma_tot, and the dark matter fraction within the half-mass radius, f_DM, in early-type galaxies. The relation can be described as gamma_tot = A f_DM + B for all systems at all redshifts. The trend is set by the decreasing importance of gas dissipation towards lower redshifts and for more massive systems. Early-type galaxies are smaller, more concentrated, have lower f_DM and steeper gamma_tot at high redshifts and at lower masses for a given redshift; f_DM and gamma_tot are good indicators for growth by "dry" merging. The values for A and B change distinctively for different feedback models, and this relation can be used as a test for such models. A similar correlation exists between gamma_tot and the stellar mass surface density Sigma_*. A model with weak stellar feedback and feedback from black holes is in best agreement with observations. All simulations, independent of the assumed feedback model, predict steeper gamma_tot and lower f_DM at higher redshifts. While the latter is in agreement with the observed trends, the former is in conflict with lensing observations, which indicate constant or decreasing gamma_tot. This discrepancy is shown to be artificial: the observed trends can be reproduced from the simulations using observational methodology to calculate the total density slopes., Comment: 17 pages, 10 figures, published by MNRAS
- Published
- 2016
- Full Text
- View/download PDF
24. Atmospheric NLTE-Models for the Spectroscopic Analysis of Blue Stars with Winds. III. X-ray emission from wind-embedded shocks
- Author
-
Carneiro, Luiz P., Puls, J., Sundqvist, J. O., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
X-rays/EUV radiation emitted from wind-embedded shocks in hot, massive stars can affect the ionization balance in their outer atmospheres, and can be the mechanism responsible for the production of highly ionized species. To allow for these processes in the context of spectral analysis, we have implemented such emission into our unified, NLTE model atmosphere/spectrum synthesis code FASTWIND. The shock structure and corresponding emission is calculated as a function of user-supplied parameters. We account for a temperature and density stratification inside the post-shock cooling zones, calculated for radiative and adiabatic cooling in the inner and outer wind, respectively. The high-energy absorption of the cool wind is considered by adding important K-shell opacities, and corresponding Auger ionization rates have been included into the NLTE network. We tested and verified our implementation carefully against corresponding results from various alternative model atmosphere codes, and studied the effects from shock emission for important ions from He, C, N, O, Si, and P. Surprisingly, dielectronic recombination turned out to play an essential role for the ionization balance of OIV/OV around Teff = 45,000 K. Finally, we investigated the behavior of the mass absorption coefficient, kappa_nu(r), important in the context of X-ray line formation in massive star winds. In almost all considered cases, direct ionization is of major influence, and Auger ionization significantly affects only NVI and OVI. The approximation of a radially constant kappa_nu is justified for r > 1.2 Rstar and lambda < 18 A, and also for many models at longer wavelengths. To estimate the actual value of this quantity, however, the HeII opacities need to be calculated from detailed NLTE modeling, at least for wavelengths longer than 18 to 20 A, and information on the individual CNO abundances has to be present., Comment: accepted by A&A
- Published
- 2016
- Full Text
- View/download PDF
25. Behavioral Crisis Management: A Quality Improvement Pilot for Improving Teamwork in a Primary Care Pediatric Setting
- Author
-
Ginsberg, Julie S., Hoffmann, Rosemary L., Lebet, Ruth, and Gonzalez, Judith Zedreck
- Published
- 2021
- Full Text
- View/download PDF
26. Simulation and experimental benchmarking of a proton pencil beam scanning nozzle for development of MRI-guided proton therapy
- Author
-
Oborn, B. M., Semioshkina, E., Kraaij, E., (0000-0002-5821-3135) Hoffmann, A. L., Oborn, B. M., Semioshkina, E., Kraaij, E., and (0000-0002-5821-3135) Hoffmann, A. L.
- Abstract
Background: MR-integrated proton therapy is under development. It consists of the unique challenge of integrating a proton pencil beam scanning (PBS) beam line nozzle with an magnetic resonance imaging (MRI) scanner.The magnetic interaction between these two components is deemed high risk as the MR images can be degraded if there is cross-talk during beam delivery and image acquisition. Purpose: To create and benchmark a self -consistent proton PBS nozzle model for empowering the next stages of MR-integrated proton therapy development, namely exploring and de-risking complete integrated prototype system designs including magnetic shielding of the PBS nozzle. Materials and Methods: Magnetic field (COMSOL Multiphysics) and radiation transport (Geant4) models of a proton PBS nozzle located at OncoRay (Dresden, Germany) were developed according to the manufacturers specifications. Geant4 simulations of the PBS process were performed by using magnetic field data generated by the COMSOL Multiphysics simulations. In total 315 spots were simulated which consisted of a 40 × 30cm2 scan pattern with 5 cm spot spacings and for proton energies of 70, 100, 150, 200, and 220 MeV. Analysis of the simulated deflection at the beam isocenter plane was performed to determine the self -consistency of the model. The magnetic fringe field from a sub selection of 24 of the 315 spot simulations were directly compared with high precision magnetometer measurements.These focused on the maximum scanning setting of ± 20 cm beam deflection as generated from the second scanning magnet in the PBS for a proton beam energy of 220 MeV. Locations along the beam line central axis (CAX) were measured at beam isocenter and downstream of 22, 47, 72, 97, and 122 cm. Horizontal off -axis positions were measured at 22 cm downstream of isocenter (± 50,± 100,and ± 150 cm from CAX). Results: The proton PBS simulations had good spatial agreement to the theoretical values in all 315 spots examined at the beam line
- Published
- 2024
27. High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial)
- Author
-
Neurologen, Brain, MS Radiotherapie, Cancer, Zegers, C. M.L., Swinnen, A., Roumen, C., Hoffmann, A. L., Troost, E. G.C., van Asch, C. J.J., Brandts, L., Compter, I., Dieleman, E. M.T., Dijkstra, J. B., Granzier, M., Hendriks, M., Hofman, P., Houben, R. M.A., Ramaekers, B., Ronner, H. E., Rouhl, R. P.W., van der Salm, S., Santegoeds, R. G.C., Verhoeff, J. J., Wagner, G. L., Zwemmer, J., Schijns, O. E.M.G., Colon, A. J., Eekers, D. B.P., Neurologen, Brain, MS Radiotherapie, Cancer, Zegers, C. M.L., Swinnen, A., Roumen, C., Hoffmann, A. L., Troost, E. G.C., van Asch, C. J.J., Brandts, L., Compter, I., Dieleman, E. M.T., Dijkstra, J. B., Granzier, M., Hendriks, M., Hofman, P., Houben, R. M.A., Ramaekers, B., Ronner, H. E., Rouhl, R. P.W., van der Salm, S., Santegoeds, R. G.C., Verhoeff, J. J., Wagner, G. L., Zwemmer, J., Schijns, O. E.M.G., Colon, A. J., and Eekers, D. B.P.
- Published
- 2024
28. Installation and acceptance testing of a whole-body rotatable in-beam MRI system for real-time MRI-guided proton therapy
- Author
-
(0000-0002-5771-5213) Schneider, S., Bertora, L., Murray, B., Murray, R., Drake, R., (0000-0002-5821-3135) Hoffmann, A. L., (0000-0002-5771-5213) Schneider, S., Bertora, L., Murray, B., Murray, R., Drake, R., and (0000-0002-5821-3135) Hoffmann, A. L.
- Abstract
Purpose: The physical integration of MRI with proton therapy (PT) into an MR-integrated PT (MRiPT) system is expected to improve the targeting accuracy of PT for the treatment of moving tumors. The objective of this project was to develop the world’s first MRiPT system providing high soft-tissue contrast real-time imaging and beam gating, combining an open 0.5 T MRI scanner with a horizontal proton pencil beam scanning (PBS) research beamline to enable gated proton beam treatments of moving tumors delivered inside the in-beam MRI scanner. This contribution provides an overview of this unique MRiPT system and presents first results showcasing its performance. Methods: The novel MRiPT setup consists of an open 0.5 T MRI scanner (P3, ASG Superconductors SpA, Genoa, Italy) positioned in close proximity to the treatment nozzle of a horizontal proton PBS research beamline (Figure 1). The liquid-Helium free, high-temperature superconducting MgB2-based magnet was installed on a 90° rotating gantry (MagnetTx Oncology Solutions, Ltd., Edmonton, Canada), enabling its static magnetic field (B0) to be either perpendicular or parallel to the central axis of the proton beam. The 35 ton system was designed to be portable inside the radiation bunker through its installation on two separable air cushion platforms also carrying a custom-designed compact aluminum Faraday cabin and a 4-degrees of freedom patient couch. At the location of the beam exit window of the nozzle, a recess having a beam entrance opening was incorporated in the wall of the Faraday cabin to achieve close positioning relative to the MRI isocenter and thus enable high proton beam quality. The beam entrance window was sealed by a thin (30 µm) aluminum foil to combine high RF attenuation and small lateral spreading of the traversing proton beam. The maneuvering of the assembly into treatment position was visually guided by room lasers that intersect at the beam isocenter and project onto the outer wall of the cabin.
- Published
- 2024
29. Cepheid Variables in the Maser-Host Galaxy NGC 4258
- Author
-
Hoffmann, Samantha L. and Macri, Lucas M.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present results of a ground-based survey for Cepheid variables in NGC 4258. This galaxy plays a key role in the Extragalactic Distance Scale due to its very precise and accurate distance determination via VLBI observations of water masers. We imaged two fields within this galaxy using the Gemini North telescope and GMOS, obtaining 16 epochs of data in the SDSS gri bands over 4 years. We carried out PSF photometry and detected 94 Cepheids with periods between 7 and 127 days, as well as an additional 215 variables which may be Cepheids or Population II pulsators. We used the Cepheid sample to test the absolute calibration of theoretical gri Period-Luminosity relations and found good agreement with the maser distance to this galaxy. The expected data products from the Large Synoptic Survey Telescope (LSST) should enable Cepheid searches out to at least 10 Mpc., Comment: Accepted for publication in the Astronomical Journal
- Published
- 2015
- Full Text
- View/download PDF
30. Comment on 'Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning'
- Author
-
Gorissen, Bram L. and Hoffmann, Aswin L.
- Subjects
Physics - Medical Physics - Abstract
Comparison of optimization algorithms for inverse treatment planning requires objective function value evaluation.
- Published
- 2015
- Full Text
- View/download PDF
31. Three-dimensional modeling of ionized gas. II. Spectral energy distributions of massive and very massive stars in stationary and time-dependent modeling of the ionization of metals in HII regions
- Author
-
Weber, J. A., Pauldrach, A. W. A., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
HII regions play a crucial role in the measurement of the chemical composition of the interstellar medium and provide fundamental data about element abundances that constrain models of galactic chemical evolution. Discrepancies that still exist between observed emission line strengths and those predicted by nebular models can be partly attributed to the spectral energy distributions (SEDs) of the sources of ionizing radiation used in the models as well as simplifying assumptions made in nebular modeling. The influence of stellar metallicity on nebular line strength ratios, via its effect on the SEDs, is of similar importance as variations in the nebular metallicity. We have computed a grid of model atmosphere SEDs for massive and very massive O-type stars covering a range of metallicities from significantly subsolar (0.1 Zsun) to supersolar (2 Zsun). The SEDs have been computed using a state-of-the-art model atmosphere code that takes into account the attenuation of the ionizing flux by the spectral lines of all important elements and the hydrodynamics of the radiatively driven winds and their influence on the SEDs. For the assessment of the SEDs in nebular simulations we have developed a (heretofore not available) 3d radiative transfer code that includes a time-dependent treatment of the metal ionization. Using the SEDs in both 1d and 3d nebular models we explore the relative influence of stellar metallicity, gas metallicity, and inhomogeneity of the gas on the nebular ionization structure and emission line strengths. We find that stellar and gas metallicity are of similar importance for establishing the line strength ratios commonly used in nebular diagnostics, whereas inhomogeneity of the gas has only a subordinate influence on the global line emission., Comment: Accepted by A&A
- Published
- 2015
- Full Text
- View/download PDF
32. Simulation and experimental benchmarking of a proton pencil beam scanning nozzle model for development of MR‐integrated proton therapy.
- Author
-
Oborn, Bradley M., Semioshkina, Ekaterina, van der Kraaij, Erik, and Hoffmann, Aswin L.
- Subjects
MAGNETIC resonance imaging ,MAGNETIC shielding ,PROTON therapy ,MAGNETIC fields ,MAGNETS ,PROTON beams - Abstract
Background: MR‐integrated proton therapy is under development. It consists of the unique challenge of integrating a proton pencil beam scanning (PBS) beam line nozzle with an magnetic resonance imaging (MRI) scanner. The magnetic interaction between these two components is deemed high risk as the MR images can be degraded if there is cross‐talk during beam delivery and image acquisition. Purpose: To create and benchmark a self‐consistent proton PBS nozzle model for empowering the next stages of MR‐integrated proton therapy development, namely exploring and de‐risking complete integrated prototype system designs including magnetic shielding of the PBS nozzle. Materials and Methods: Magnetic field (COMSOL Multiphysics${\text{Multiphysics}}$) and radiation transport (Geant4) models of a proton PBS nozzle located at OncoRay (Dresden, Germany) were developed according to the manufacturers specifications. Geant4 simulations of the PBS process were performed by using magnetic field data generated by the COMSOL Multiphysics${\text{Multiphysics}}$ simulations. In total 315 spots were simulated which consisted of a 40×30cm2$40\times 30\,{\text{cm}}^{2}$ scan pattern with 5 cm spot spacings and for proton energies of 70, 100, 150, 200, and 220 MeV. Analysis of the simulated deflection at the beam isocenter plane was performed to determine the self‐consistency of the model. The magnetic fringe field from a sub selection of 24 of the 315 spot simulations were directly compared with high precision magnetometer measurements. These focused on the maximum scanning setting of ±$\pm$ 20 cm beam deflection as generated from the second scanning magnet in the PBS for a proton beam energy of 220 MeV. Locations along the beam line central axis (CAX) were measured at beam isocenter and downstream of 22, 47, 72, 97, and 122 cm. Horizontal off‐axis positions were measured at 22 cm downstream of isocenter (±$\pm$ 50, ±$\pm$ 100, and ±$\pm$ 150 cm from CAX). Results: The proton PBS simulations had good spatial agreement to the theoretical values in all 315 spots examined at the beam line isocenter plane (0–2.9 mm differences or within 1.5 % of the local spot deflection amount). Careful analysis of the experimental measurements were able to isolate the changes in magnetic fields due solely to the scanning magnet contribution, and showed 1.9 ±$\pm$ 1.2 μT$\bf{\mu} {\text{T}}$–9.4 ±$\pm$ 1.2 μT$\bf{\mu} {\text{T}}$ changes over the range of measurement locations. Direct comparison with the equivalent simulations matched within the measurement apparatus and setup uncertainty in all but one measurement point. Conclusions: For the first time a robust, accurate and self‐consistent model of a proton PBS nozzle assembly has been created and successfully benchmarked for the purposes of advancing MR‐integrated proton therapy research. The model will enable confidence in further simulation based work on fully integrated designs including MRI scanners and PBS nozzle magnetic shielding in order to de‐risk and realize the full potential of MR‐integrated proton therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Mixed integer programming improves comprehensibility and plan quality in inverse optimization of prostate HDR-brachytherapy
- Author
-
Gorissen, Bram L., Hertog, Dick den, and Hoffmann, Aswin L.
- Subjects
Physics - Medical Physics - Abstract
Current inverse treatment planning methods that optimize both catheter positions and dwell times in prostate HDR brachytherapy use surrogate linear or quadratic objective functions that have no direct interpretation in terms of dose-volume histogram (DVH) criteria, do not result in an optimum or have long solution times. We decrease the solution time of existing linear and quadratic dose-based programming models (LP and QP, respectively) to allow optimizing over potential catheter positions using mixed integer programming. An additional average speed-up of 75% can be obtained by stopping the solver at an early stage, without deterioration of the plan quality. For a fixed catheter configuration, the dwell time optimization model LP solves to optimality in less than 15 seconds, which confirms earlier results. We propose an iterative procedure for QP that allows to prescribe the target dose as an interval, while retaining independence between the solution time and the number of dose calculation points. This iterative procedure is comparable in speed to the LP model, and produces better plans than the non-iterative QP. We formulate a new dose-volume based model that maximizes $V_{100\%}$ while satisfying pre-set DVH-criteria. This model optimizes both catheter positions and dwell times within a few minutes depending on prostate volume and number of catheters, optimizes dwell times within 35 seconds, and gives better DVH statistics than dose-based models. The solutions suggest that the correlation between objective value and clinical plan quality is weak in existing dose-based models.
- Published
- 2014
- Full Text
- View/download PDF
34. Representations of gender in Soviet war memorials
- Author
-
Hoffmann, David L., primary
- Published
- 2021
- Full Text
- View/download PDF
35. The Memory of the Second World War in Soviet and Post-Soviet Russia
- Author
-
Hoffmann, David L., primary
- Published
- 2021
- Full Text
- View/download PDF
36. Introduction
- Author
-
Hoffmann, David L., primary
- Published
- 2021
- Full Text
- View/download PDF
37. Non-LTE models for synthetic spectra of type Ia supernovae. IV. A modified Feautrier scheme for opacity-sampled pseudo-continua at high expansion velocities and application to synthetic SN Ia spectra
- Author
-
Hoffmann, T. L., Sauer, D. N., Pauldrach, A. W. A., and Hultzsch, P. J. N.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Context. Type Ia supernovae (SN Ia) have become an invaluable cosmological tool as their exceptional brightness makes them observable even at very large distances (up to redshifts around z~1). To investigate possible systematic differences between local and distant SN Ia requires detailed models whose synthetic spectra can be compared to observations, and in which the solution of the radiative transfer is a key ingredient. One commonly employed method is the Feautrier scheme, which is generally very robust, but which can yield wrong results under certain conditions that frequently occur in the modelling of supernova ejecta or even in the radiatively driven expanding atmospheres of hot stars. Methods. We use a sophisticated model atmosphere code which takes into account the non-LTE effects and high velocity gradients that strongly affect the physics of SN Ia atmospheres at all wavelengths to simulate the formation of SN Ia spectra by the thousands of strong spectral lines which intricately interact with the "pseudo-continuum" formed entirely by these Doppler-shifted lines themselves. We focus to an investigation of the behavior of the Feautrier scheme under these conditions. Results. Synthetic spectra of SN Ia, a complex product of computer models replicating numerous physical processes that determine the conditions of matter and radiation in the ejecta, are affected by large spatial jumps of the line-dominated opacities and source functions for which the application of even well-established methods may harbor certain pitfalls. We analyze the conditions that can lead to a breakdown of conventional procedures and we derive for the Feautrier radiative transfer solver a modified description which yields more accurate results in the given circumstances., Comment: 11 pages, 9 figures. Submitted to A&A
- Published
- 2013
- Full Text
- View/download PDF
38. Non-LTE models for synthetic spectra of type Ia supernovae. III. An accelerated lambda iteration procedure for the mutual interaction of strong spectral lines in SN Ia models with and without energy deposition
- Author
-
Pauldrach, A. W. A., Hoffmann, T. L., and Hultzsch, P. J. N.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Context. Spectroscopic analyses to interpret the spectra of the brightest supernovae from the UV to the near-IR provide a powerful tool with great astrophysical potential for the determination of the physical state of the ejecta, their chemical composition, and the SNe distances even at significant redshifts. Methods. We report on improvements of computing synthetic spectra for SNIa with respect to i) an improved and sophisticated treatment of thousands of strong lines that interact intricately with the "pseudo-continuum" formed entirely by Doppler- shifted spectral lines, ii) an improved and expanded atomic database, and iii) the inclusion of energy deposition within the ejecta. Results. We show that an accelerated lambda iteration procedure we have developed for the mutual interaction of strong spectral lines appearing in the atmospheres of SNeIa solves the longstanding problem of transferring the radiative energy from the UV into the optical regime. In detail we discuss applications of the diagnostic technique by example of a standard SNIa, where the comparison of calculated and observed spectra revealed that in the early phases the consideration of the energy deposition within the spectrum-forming regions of the ejecta does not qualitatively alter the shape of the spectra. Conclusions. The results of our investigation lead to an improved understanding of how the shape of the spectrum changes radically as function of depth in the ejecta, and show how different emergent spectra are formed as a result of the particular physical properties of SNe Ia ejecta and the resulting peculiarities in the radiative transfer. This provides an important insight into the process of extracting information from observed SNIa spectra, since these spectra are a complex product of numerous unobservable SNIa spectral features which are thus analyzed in parallel to the observable spectral features., Comment: 27 pages, 19 figures. Submitted to A&A, revised version
- Published
- 2013
- Full Text
- View/download PDF
39. Radiation-driven winds of hot luminous stars. XVIII. The reliability of stellar and wind parameter determinations from spectral analysis of selected central stars of planetary nebulae and the possibility of single-star SN Ia progenitors
- Author
-
Kaschinski, C. B., Pauldrach, A. W. A., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Context. The uncertainty in the degree to which radiation-driven winds of hot stars might be affected by small inhomogeneities in the density leads to a corresponding uncertainty in the determination of the atmospheric mass loss rates from the strength of optical recombination lines. Furthermore, the optical recombination lines also react sensitively to even small changes in the density structure resulting from the (often assumed instead of computed) velocity law of the outflow. This raises the question of how reliable the parameter determinations from such lines are. Results. The discrepancy between the optical and the UV analyses is confirmed to be the result of a missing consistency between stellar and wind parameters in the optical analysis. The influence of the density (velocity field) is of the same order as that of moderate clumping factors. Moderate clumping factors leave the UV spectra mostly unaffected, indicating that the influence on the ionization balance, and thus on the radiative acceleration, is small. Instead of the erratic behavior of the clumping factors claimed from the optical analyses, our analysis based on the velocity field computed from radiative driving yields similar clumping factors for all CSPNs. The shock temperatures and the ratios of X-ray to bolometric luminosity required to reproduce the highly ionized Ovi line agree with those known from massive O stars, again confirming the similarity of O-type CSPN and massive O star atmospheres. Conclusions. The similarity of the winds of O-type CSPNs and those of massive O stars justifies using the same methods based on the dynamics of radiation-driven winds in their analysis, thus supporting the earlier result that several of the CSPNs in the sample have near-Chandrasekhar-limit masses and may thus be possible single-star progenitors of type Ia supernovae., Comment: 24 pages, 18 figures. Submitted to A&A
- Published
- 2013
40. Three-Dimensional Modelling of Ionized Gas. I. Did very massive stars of different metallicities drive the second cosmic reionization?
- Author
-
Weber, J. A., Pauldrach, A. W. A., Knogl, J. S., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The first generation of stars that formed directly from the primordial gas played a crucial role in the early phase of the reionization of the universe. Because of the short lifetimes of these stars the metals produced in their cores were quickly returned to the environment, from which early PopII stars with a different initial mass function and different SEDs were formed, already much earlier than the time at which the universe became completely reionized at a redshift of z~6. Using a state-of-the-art model atmosphere code we calculate realistic SEDs of very massive stars (VMSs) of different metallicities to serve as input for the 3-dimensional multi-frequency radiative transfer code we have developed to simulate the temporal evolution of the ionization of the inhomogeneous interstellar and intergalactic medium, using multiple stellar clusters as sources of ionizing radiation. Our tool handles distributions of numerous radiative sources characterized by high resolution synthetic SEDs, and yields occupation numbers of the required energy levels of the most important elements which are treated in NLTE consistently with the 3d radiative transfer. We further demonstrate that the increasing metallicity of the radiative sources in the transition from PopIII stars to PopII stars has a strong impact on the hardness of the emitted spectrum, and hence on the reionization history of helium. A top-heavy stellar mass distribution characterized by VMSs forming in chemically evolved clusters of high core mass density may not only provide the progenitors of intermediate-mass and supermassive black holes (SMBHs), but also play an important role for the reionization of HeII. The number of VMSs required to reionize HeII by a redshift of z~2.5 is astonishingly close to the number of VMSs required to explain galactic SMBHs if one assumes that these have been formed by mergers of smaller black holes., Comment: Accepted by A&A. 23 pages, 26 figures
- Published
- 2013
- Full Text
- View/download PDF
41. North Iberian temperature and rainfall seasonality over the Younger Dryas and Holocene
- Author
-
Baldini, Lisa M., Baldini, James U.L., McDermott, Frank, Arias, Pablo, Cueto, Marián, Fairchild, Ian J., Hoffmann, Dirk L., Mattey, David P., Müller, Wolfgang, Nita, Dan Constantin, Ontañón, Roberto, Garciá-Moncó, Cristina, and Richards, David A.
- Published
- 2019
- Full Text
- View/download PDF
42. Characterizing geometrical accuracy in clinically optimised 7T and 3T magnetic resonance images for high-precision radiation treatment of brain tumours
- Author
-
Peerlings, Jurgen, Compter, Inge, Janssen, Fiere, Wiggins, Christopher J., Postma, Alida A., Mottaghy, Felix M., Lambin, Philippe, and Hoffmann, Aswin L.
- Published
- 2019
- Full Text
- View/download PDF
43. Ano-rectal wall dose-surface maps localize the dosimetric benefit of hydrogel rectum spacers in prostate cancer radiotherapy
- Author
-
Vanneste, Ben G.L., Buettner, Florian, Pinkawa, Michael, Lambin, Philippe, and Hoffmann, Aswin L.
- Published
- 2019
- Full Text
- View/download PDF
44. Numerical Models for the Diffuse Ionized Gas in Galaxies. I. Synthetic spectra of thermally excited gas with turbulent magnetic reconnection as energy source
- Author
-
Hoffmann, T. L., Lieb, S., Pauldrach, A. W. A., Lesch, H., Hultzsch, P. J. N., and Birk, G. T.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Aims: The aim of this work is to verify whether turbulent magnetic reconnection can provide the additional energy input required to explain the up to now only poorly understood ionization mechanism of the diffuse ionized gas (DIG) in galaxies and its observed emission line spectra. Methods: We use a detailed non-LTE radiative transfer code that does not make use of the usual restrictive gaseous nebula approximations to compute synthetic spectra for gas at low densities. Excitation of the gas is via an additional heating term in the energy balance as well as by photoionization. Numerical values for this heating term are derived from three-dimensional resistive magnetohydrodynamic two-fluid plasma--neutral-gas simulations to compute energy dissipation rates for the DIG under typical conditions. Results: Our simulations show that magnetic reconnection can liberate enough energy to by itself fully or partially ionize the gas. However, synthetic spectra from purely thermally excited gas are incompatible with the observed spectra; a photoionization source must additionally be present to establish the correct (observed) ionization balance in the gas., Comment: Accepted by A&A
- Published
- 2012
- Full Text
- View/download PDF
45. Radiation-driven winds of hot luminous stars XVII. Parameters of selected central stars of PN from consistent optical and UV spectral analysis and the universality of the mass-luminosity relation
- Author
-
Kaschinski, C. B., Pauldrach, A. W. A., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Context: The commonly accepted mass-luminosity relation of central stars of planetary nebulae (CSPNs) might not be universally valid. While earlier optical analyses could not derive masses and luminosities independently (instead taking them from theoretical evolutionary models) hydrodynamically consistent modelling of the stellar winds allows using fits to the UV spectra to consistently determine also stellar radii, masses, and luminosities without assuming a mass-luminosity relation. Recent application to a sample of CSPNs raised questions regarding the validity of the theoretical mass-luminosity relation of CSPNs. Aims: The results of the earlier UV analysis are reassessed by means of a simultaneous comparison of observed optical and UV spectra with corresponding synthetic spectra. Methods: Using published stellar parameters (a) from a consistent UV analysis and (b) from fits to optical H and He lines, we calculate simultaneous optical and UV spectra with our model atmosphere code, which has been improved by implementing Stark broadening for H and He lines. Results: Spectra computed with the parameter sets from the UV analysis yield good agreement to the observations, but spectra computed with the stellar parameters from the published optical analysis and using corresponding consistent wind parameters show large discrepancies to both the observed optical and UV spectra. The published optical analyses give good fits to the observed spectrum only because the wind parameters assumed in these analyses are inconsistent with their stellar parameters. By enforcing consistency between stellar and wind parameters, stellar parameters are obtained which disagree with the core-mass-luminosity relation for the objects analyzed. This disagreement is also evident from a completely different approach: an investigation of the dynamical wind parameters., Comment: 22 pages, 18 fugres
- Published
- 2012
- Full Text
- View/download PDF
46. Radiation-driven winds of hot luminous stars. XVI. Expanding atmospheres of massive and very massive stars and the evolution of dense stellar clusters
- Author
-
Pauldrach, A. W. A., Vanbeveren, D., and Hoffmann, T. L.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Context: Starbursts, and particularly their high-mass stars, play an essential role in the evolution of galaxies. The winds of massive stars not only significantly influence their surroundings, but the mass loss also profoundly affects the evolution of the stars themselves. In addition to the evolution of each star, the evolution of the dense cores of massive starburst clusters is affected by N-body interactions, and the formation of very massive stars via mergers may be decisive for the evolution of the cluster. Aims: To introduce an advanced diagnostic method of O-type stellar atmospheres with winds, including an assessment of the accuracy of the determinations of abundances, stellar and wind parameters. Methods: We combine consistent models of expanding atmospheres with detailed stellar evolutionary calculations of massive and very massive single stars with regard to the evolution of dense stellar clusters. Accurate predictions of the mass loss rates of very massive stars requires a highly consistent treatment of the statistical equilibrium and the hydrodynamic and radiative processes in the expanding atmospheres. Results: We present computed mass loss rates, terminal wind velocities, and spectral energy distributions of massive and very massive stars of different metallicities, calculated from atmospheric models with an improved level of consistency. Conclusions: Stellar evolutionary calculations using our computed mass loss rates show that low-metallicity very massive stars lose only a very small amount of their mass, making it unlikely that very massive population III stars cause a significant helium enrichment of the interstellar medium. Solar-metallicity stars have higher mass-loss rates, but these are not so high to exclude very massive stars formed by mergers in dense clusters from ending their life massive enough to form intermediate-mass black holes., Comment: Accepted by A&A
- Published
- 2011
- Full Text
- View/download PDF
47. Prediction of radiation pneumonitis using the effective α/β of lungs and heart in NSCLC patients treated with proton beam therapy
- Author
-
Weiß, Albrecht, primary, Löck, Steffen, additional, Xu, Ting, additional, Liao, Zhongxing, additional, Hoffmann, Aswin L., additional, and Troost, Esther G.C., additional
- Published
- 2023
- Full Text
- View/download PDF
48. TECHNICAL COMMENT ABSTRACTS
- Author
-
Hoffmann, D. L., Standish, C. D., García-Diez, M., Pettitt, P. B., Milton, J. A., Zilhão, J., Alcolea-González, J.J., Cantalejo-Duarte, P., Collado, H., de Balbín, R., Lorblanchet, M., Ramos-Muñoz, J., Weniger, G.-Ch., and Pike, A. W. G.
- Published
- 2018
49. Impact of climate change on the transition of Neanderthals to modern humans in Europe
- Author
-
Staubwasser, Michael, Drăguşin, Virgil, Onac, Bogdan P., Assonov, Sergey, Ersek, Vasile, Hoffmann, Dirk L., and Veres, Daniel
- Published
- 2018
50. U-Th dating of carbonate crusts reveals Neandertal origin of Iberian cave art
- Author
-
Hoffmann, D. L., Standish, C. D., García-Diez, M., Pettitt, P. B., Milton, J. A., Zilhão, J., Alcolea-González, J. J., Cantalejo-Duarte, P., Collado, H., de Balbín, R., Lorblanchet, M., Ramos-Muñoz, J., Weniger, G.-Ch., and Pike, A. W. G.
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.