Search

Objective: Latent class analysis was used to identify functional classes among patients hospitalized for pneumonia. Then, we determined predictors of class membership and examined variation in distal outcomes among the functional classes. Design: An observational, cross-sectional study design was used with retrospectively collected data between 2014 and 2018. Setting: The study setting was a single health system including 5 acute care hospitals. Participants: A total of 969 individuals hospitalized with the primary diagnosis of pneumonia and receipt of an occupational and/or physical therapy evaluation were included in the study. Interventions: Not applicable. Main Outcomes: The following 5 distal outcomes were examined: (1) occupational therapy treatment use, (2) physical therapy treatment use, (3) discharge to home with no services, (4) discharge to home with home health, and (5) institutional discharge. Results: Five functional classes were identified and labeled as follows: Globally impaired, Independent with low-level self-care, Independent low-level mobility, Independent self-care, and Independent. Probability of occupational therapy treatment use (χ2[4]=50.26, P

Category: Midfoot/Forefoot; Hindfoot Introduction/Purpose: Although operative treatment of the flexible progressive collapsing foot deformity (PCFD) remains controversial, correction of residual forefoot varus and stabilization of the medial column are important components of reconstruction. An opening wedge medial cuneiform osteotomy or first tarsometatarsal fusion is traditionally performed to plantarflex the first metatarsal. More recently, tendon transfers such as a peroneus brevis (PB) to peroneus longus (PL) have been proposed. However, there is little data to support their use. The aim of our study was to determine the effect of an isolated PB- to-PL transfer (PBT) on medial column and hindfoot joint kinematics in a simulated PCFD (sPCFD) cadaveric model using a robotic gait simulator. We hypothesized that a PBT in a sPCFD model would partially restore kinematics to the intact state. Methods: A validated six-degree of freedom robot (Baxter et al., 2016) was used to simulate the stance phase of level walking for 6 mid-tibia cadaveric specimens (3 male; age: 72 ± 8 years). An eight-camera motion capture system was used to track reflective markers fixed to bones of the foot and ankle. Three conditions were tested for each specimen: intact, sPCFD (Henry et al., 2022), and after PBT. The PBT was performed by transecting the PB and advancing the proximal stump 1 cm into the PL (Sanhudo, 2019). Outcome measures included kinematics of the talonavicular, subtalar, and first tarsometatarsal joints. Maximum differences between the PBT and sPCFD conditions and 95% confidence intervals (95%CIs) were calculated. The percent deformity correction was determined by dividing the difference between the PB and sPCFD states by the difference between the intact and sPCFD states at the site of maximum deformity correction. Results: Relative to the sPCFD condition, the PBT resulted in a maximum increase in talonavicular plantarflexion of 1.8° (95%CI 0.9°-2.7°) with 159% correction during midstance, decrease in talonavicular abduction of 1.5° (95%CI 0.3°-2.8°) with 65% correction during midstance, and decrease in talonavicular eversion of 2.4° (95%CI 1.2°-3.8°) with 90% correction during mid-to- late stance. All deformities had consistent correction at the talonavicular joint during stance (Figure 1). Additionally, the PBT resulted in a maximum increase in subtalar plantarflexion by 0.8° (95%CI 0.3°-1.8°) with 155% correction in early stance, decrease in subtalar abduction by 0.8° (95%CI 0.5°-1.2°) with 191% correction during early stance, and decrease in subtalar eversion by 1.5° (95%CI 0.5°-2.2°) with 178% correction during mid-stance. There was no effect on first tarsometatarsal joint kinematics. Conclusion: A PB-to-PL transfer in a sPCFD model resulted in the correction of multiple deformities including increased plantarflexion and decreased abduction at the talonavicular joint compared to the sPCFD without the transfer, most notably during PB activation in stance. The PBT also decreased eversion at the talonavicular and subtalar joints. Our results suggest that the addition of a PBT as part of the surgical management of the flexible PCFD contributes to correction of the residual forefoot varus, midfoot abduction, and hindfoot valgus deformities by plantarflexing through the medial column and removing a deforming force on the foot by the PB.

Category: Ankle; Basic Sciences/Biologics Introduction/Purpose: Although double hindfoot arthrodesis (subtalar and talonavicular) provides pain relief and deformity correction for patients with end-stage arthritis, altered ankle biomechanics may occur following these procedures. Furthermore, it has been reported that hindfoot fusions may lead to progressive ankle degenerative changes and a higher failure rate in patients undergoing total ankle arthroplasty. Previous biomechanical studies demonstrated that hindfoot fusion altered ankle joint kinematics and contact mechanics during simplified loading scenarios, but the effect during dynamic activity is unknown. Therefore, this study sought to quantify the changes in ankle kinematics after a double hindfoot arthrodesis during the stance phase of simulated gait. In addition, we sought to assess whether the sequence in which joints are fused plays a role in altering ankle kinematics. Methods: Fourteen mid-tibia specimens underwent stance phase simulations of level walking using a validated six-degree of freedom robot. All specimens had neutral hindfoot alignment. An eight-camera motion system tracked reflective markers in the tibia, talus, calcaneus, and navicular bones. Simulated arthrodeses of the subtalar and talonavicular joints were performed using two 7.0mm and two 5.5mm crossing screws, respectively. The subtalar alignment was set at 5º valgus, and the talonavicular at neutral abduction/adduction. Fluoroscopic images confirmed proper screw position and hindfoot alignment. Each specimen was tested in three conditions: pre-arthrodesis(intact), isolated arthrodesis(subtalar or talonavicular joint), and double arthrodesis(double). Specimens were further divided into two groups depending on whether the subtalar(STDouble) or talonavicular(TNDouble) joint was fused first. Ankle kinematics were calculated for each condition for the entire cohort of specimens and each of the two groups. Bias-corrected 95% confidence intervals of the difference in ankle kinematics relative to the intact condition were constructed. Results: Double hindfoot arthrodesis significantly altered ankle kinematics(Figure1A). Ankle plantarflexion decreased during heel strike by up to 2.0° on average and increased during toe-off by 6.5° compared to the intact condition. Ankle eversion increased by 1.5º and 2.5º on average during mid- and late stance, respectively. Internal rotation decreased during midstance by 1.1º on average and increased in late stance by 4.5°. The order in which hindfoot joints were fused significantly influenced ankle kinematics(Figure1B). On average, the TNDouble condition produced 2.3º and 3.5º more ankle eversion during the mid- and late stance, respectively, and 2.10° more ankle internal rotation during the early stance compared to the STDouble condition (not shown). Significant changes were also present after isolated hindfoot arthrodeses and remained consistent after the double arthrodesis. Conclusion: Double hindfoot arthrodesis significantly altered ankle kinematics throughout stance. Ankle kinematics also differed depending on which joint was fused first. Notably, the TNDouble condition produced more ankle internal rotation during early stance and more ankle eversion during mid- and late stance compared to the STDouble condition. This finding suggests that the sequence in which joints are fused affects the resultant ankle kinematics. Finally, the kinematic changes after isolated hindfoot arthrodesis remained consistent after incorporating the second joint into the fusion. It appears that once one joint needs to be fused, avoiding the double arthrodesis may not necessarily protect the ankle.

Category: Hindfoot; Midfoot/Forefoot Introduction/Purpose: Medial longitudinal arch collapse is one of the key clinical and radiographic features of progressive collapsing foot deformity (PCFD) and can occur anywhere within its three constituents: first tarsometatarsal (TMT1), naviculo- cuneiform (NC), and talonavicular (TN) joints. Medial column osteotomy or fusion has typically been utilized to address this instability. A new procedure involving transferring the flexor hallucis longus (FHL) tendon to the 1st metatarsal base has shown promising results in restoring radiographic alignment of the entire medial column in conjunction with a hindfoot procedure. However, the mechanism of correction in a dynamic environment is unclear. Thus, this study examined the effect of medial column stabilization using FHL transfer on the foot and ankle kinematics during stance phase. Methods: Twelve mid-tibia cadaveric specimen (6 male; Age 48 ± 16 years) underwent stance phase simulations using a validated six-degree of freedom robotic gait simulator. Three conditions were tested each cadaveric specimen: pre-deformity (Intact), after creating a simulated progressive collapsing foot deformity (sPCFD), and after an FHL transfer (FHL). Motion capture cameras tracked the motion of retroreflective markers inserted into bones of the foot and ankle. The FHL transfer was performed on each specimen by harvesting the FHL tendon at its distal insertion and fixing it in the 1st metatarsal with a biotenodesis screw (Figure 1A). Outcome measures include joint rotations of the TMT1, NC, TN, subtalar, and ankle joint. Significant differences (p < 0.05) in joint kinematics were statistically analyzed by constructing 95% confidence intervals of the repeated measures difference between both the sPCFD and FHL conditions and the intact condition. Results: The FHL condition demonstrated significant differences in the kinematics of the medial column compared to the sPCFD condition (Figure 1B). The TMT1 joint showed increased plantarflexion in early and late stance, as well as increased eversion during early and mid-stance. The NC joint demonstrated increased plantarflexion, eversion, and abduction during early stance. At the TN joint, there was increased inversion during early and late stance, as well as increased adduction during mid-stance. At the subtalar joint, subtalar eversion was decreased during early stance, and no significant differences were observed from the intact condition throughout stance. No differences were found in the ankle joint kinematics across all conditions. Conclusion: The results of our study demonstrate that the medial column stabilization procedure with FHL transfer can improve the kinematics of the medial column in sPCFD. Additionally, the correction at the TN and subtalar joint demonstrates the potential efficacy of this procedure for hindfoot correction. The correction occurred during the earlier stance phase as well when the FHL is not active, suggesting that this procedure provides correction in both a dynamic and static manner. This procedure can be used in conjunction with hindfoot corrective procedures in PCFD, particularly when preoperative imaging suggests multiple levels of instability within the medial column.

Category: Hindfoot; Midfoot/Forefoot; Other Introduction/Purpose: Lateral column lengthening (LCL) is an established procedure for progressive collapsing foot deformity (PCFD) patients. While functional improvements are often reported after LCL, increased post-surgical lateral foot pain, attributed to decreased subtalar joint motion, remains a concern. The optimal wedge size is determined intraoperatively by measuring passive eversion of the hindfoot to ensure adequate eversion motion and radiographic correction. However, it is unknown whether a subjective assessment of passive eversion is associated with objective postoperative measurements of foot stiffness, such as plantar pressure. Our goal was to quantify the relationship between eversion during a passive assessment and plantar pressures during simulations of level walking. We hypothesized that a strong relationship exists between the location of plantar pressure and the eversion measured with passive manipulation. Methods: A deformity was created in ten mid-tibia cadaveric specimens (four female, age range: 35-72) by transecting the spring ligament and medial talonavicular joint capsule followed by cyclic loading. A six degrees-of-freedom robotic gait simulator was used to simulate the stance phase of level walking. Joint kinematics and plantar pressure data were collected during each simulation. A passive assessment of hindfoot eversion was then conducted manually by a fellowship-trained orthopaedic surgeon and recorded by the motion capture system. Five conditions were tested: intact, PCFD, and three LCL wedge conditions (4, 6, 8mm). Outcome measures for each condition included the lateral-to-medial forefoot plantar pressure ratio during walking simulations and the peak subtalar eversion measured during the assessment. A linear mixed effects model was used to determine the association between the plantar pressure and LCL wedge thickness. Pearson correlation coefficients were calculated to determine the relationship between subtalar eversion and plantar pressure. Results: There was a significant relationship between the size of LCL wedge and the forefoot lateral-to-medial average pressure ratio (p

Category: Ankle; Ankle Arthritis; Basic Sciences/Biologics Introduction/Purpose: Clinical and functional improvement after total ankle arthroplasty (TAA) in end-stage ankle arthritis has been well documented. However, despite the implantation of TAA devices designed to restore normal walking kinematics, patients with end-stage arthritis develop compensatory walking patterns which do not return to normal, postoperatively. This discrepancy between the normative and adaptive gait patterns could influence implant loading and intended function; however, the independent influence of implant constraints and adaptive gait on joint function is unknown. Therefore, this study aimed to isolate the individual and combined effects of TAA implantation and gait adaption from ankle arthritis on foot and ankle kinematics during simulated level walking. We hypothesized that foot and ankle kinematics would primarily be altered through adaptations in gait resulting from ankle arthritis. Methods: Twelve mid-tibia cadaveric specimens were utilized. A validated six-degree of freedom robotic gait simulator was used to simulate the stance phase [3]. The specimen was first placed on the simulator in the intact condition, simulated with both healthy and adaptive gait inputs collected from healthy and post-surgical TAA subjects (average follow-up: 46 months), respectively. The TAA (Salto Talaris; Integra LifeSciences) was then implanted, and adaptive and healthy gait trials were conducted in the implanted condition. Four conditions were collected on each specimen: intact with a healthy walking trajectory (intact- healthy), intact with an adaptive walking trajectory (intact-adaptive), implanted with TAA with a healthy walking trajectory (TAA- healthy), and implanted with TAA with an adaptive gait trajectory (TAA-adaptive). Ankle, subtalar, and talonavicular joint kinematics in each condition were compared to intact-healthy to isolate the effects of implantation and adaptive gait on kinematics. Bias-corrected 95% confidence intervals were calculated for the difference between conditions. Results: Significant differences were observed in the ankle, subtalar, and talonavicular joints across all comparisons. In the comparison between the intact-healthy and intact-adaptive conditions, to isolate the effect of adaptive gait (Figure 1A), ankle dorsiflexion and subtalar eversion increased late in stance, while talonavicular abduction increased in early and late stance. In the comparison between intact-healthy and TAA-healthy conditions, to isolate the effect of implant constraints (Figure 1B), ankle plantarflexion, subtalar eversion, and talonavicular abduction significantly increased in mid-stance after implantation. In the comparison between the intact healthy and the TAA-adaptive conditions, to evaluate the combined effect of adaptive gait and implantation (Figure 1C), ankle plantarflexion was increased during early stance and decreased in late stance, subtalar eversion increased during mid-to-late stance, and talonavicular abduction increased throughout most of the stance phase. Conclusion: The results from this study indicate that both gait adaption and implant constraint contributed to changes in ankle and adjacent joint kinematics. The two factors appear to influence different aspects of the stance phase, where gait adaption appeared to influence early, and late stance and implantation influenced kinematics in mid-stance. The synergistic influence of both factors seemed to exaggerate deviations away from normal kinematics in the subtalar and talonavicular joints while negating deviations from normal in the ankle joint. This suggests that ankle implants designed to restore normative walking patterns may not account for the loading environment seen in patients.

Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Progressive collapsing foot deformity (PCFD) is a 3-dimensional pathology associated with insufficiency of the posterior tibial tendon (PTT), ligamentous failure, joint malalignment, and aberrant plantar force distribution. Existing knowledge of PCFD consists of static measurements, which provide information about the structure of the foot but none about its function. Cadaveric gait models provide an opportunity to measure motion both at the joints primarily affected in PCFD and the adjacent joints that are at risk for progressive subluxation and arthritis. This study sought to develop a flatfoot model for a robotic gait simulator and quantify gait kinematics and plantar pressure between normal and flatfoot conditions, which we hypothesized would be altered after the creation of a flatfoot deformity model. Methods: Cadaveric specimens were loaded on a 6-degree of freedom robotic gait simulator and the extrinsic tendons were attached to linear motors. Ground reaction forces and muscle forces were optimized utilizing an established iterative process. An 8-camera motion capture system was utilized to calculate joint kinematics using reflective markers attached by k-wires into bone. A plantar pressure mat attached to the force platform was used to calculate the center of pressure excursion index (CPEI) for each condition. The flatfoot model was created via sectioning of the spring ligament and medial talonavicular joint capsule followed by cyclic axial compression until 5-15° of talonavicular abduction was achieved in a static, loaded pose. Testing of the flatfoot state was then performed with inactivation of the PTT. Bias-corrected bootstrapped 95% confidence intervals were constructed from the repeated measures difference between flatfoot and normal conditions. Paired t-tests were used to compare the CPEI between conditions. Results: Twelve mid-tibia cadaveric specimens (mean age 73 years, 8 female) with no prior foot/ankle surgery were used. There were significant differences in kinematics between normal and PCFD conditions at the ankle, subtalar, and talonavicular joints (Figure). There was significantly increased ankle plantar flexion in flatfoot in the first 80% of stance phase. There was significantly greater subtalar eversion in flatfoot compared to normal from 10-90% of stance phase. Talonavicular abduction and eversion were also significantly greater in flatfoot from 10-100% of stance. The CPEI was significantly decreased in the flatfoot condition (Figure), indicating a medialization in center of pressure (p

Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Progressive collapsing foot deformity (PCFD) is a complex 3-dimensional pathology with a wide variety of surgical treatments. Regardless of technique, operative management of PCFD aims to restore normal foot architecture with attention to avoid the consequences of under- or over-correction. However, current methods of evaluating PCFD correction rely on static measurements, which do not assess dynamic function of the foot. Recent advances in robotic technology allow for the dynamic assessment of surgical correction of PCFD. This study sought to assess the effects of 2 osteotomies for PCFD, the medializing calcaneal osteotomy (MCO) and lateral column lengthening (LCL), on kinematics and plantar pressure during simulated gait. We hypothesized that the combination of LCL and MCO would restore joint kinematics and plantar pressure values to normal levels. Methods: Twelve cadaveric mid-tibia specimens (mean age 73 years, 8 female) were loaded on a 6-degree of freedom robotic gait simulator. Ground reaction forces and muscle forces were optimized utilizing an established iterative process. An 8-camera motion capture system was utilized to calculate joint kinematics using reflective markers attached by k-wires into bone. Plantar pressures were recorded using a pedography mat attached to the force platform. Testing was performed first in the native intact state, and again after creation of the flatfoot model. After flatfoot testing, surgical reconstruction and testing were performed in stages with MCO, and LCL with sequential 6mm and 8mm grafts. Bias-corrected bootstrapped 95% confidence intervals were calculated from the repeated measures difference between normal, flatfoot, post-MCO, post-MCO and post-reconstructive conditions. Center of plantar pressure excursion index (CPEI) was calculated and compared between conditions using a repeated measures ANOVA with Tukey post hoc analysis. Results: Overall, surgical correction restored kinematics to normal levels (Figure). MCO alone resulted in statistically significant improvement in subtalar eversion in the first 20% of stance, and post-MCO subtalar kinematics were statistically similar to normal. LCL (either 6mm and 8mm) alone did not significantly correct talonavicular abduction after PCFD. However, in conjunction with MCO, LCL was able to significantly correct talonavicular kinematics throughout the majority of stance phase, with kinematics statistically similar to normal levels. Each surgical step (LCL 6mm, LCL 8mm, MCO) resulted in sequential lateralization of the center of plantar pressure. At the culmination of surgical reconstruction (MCO + LCL), plantar pressure was significantly corrected compared to PCFD (P

OBJECTIVES:. This report aims to characterize the kinetics of serum albumin in critically ill patients with coronavirus disease 2019 compared with critically ill patients with sepsis-induced acute respiratory distress syndrome. DESIGN:. Retrospective analysis. SETTING:. We analyzed two critically ill cohorts, one with coronavirus disease 2019 and another with sepsis-induced acute respiratory distress syndrome, treated in the New York Presbyterian Hospital-Weill Cornell Medical Center. PATIENTS:. Adult patients in the coronavirus disease 2019 cohort, diagnosed through reverse transcriptase-polymerase chain reaction assays performed on nasopharyngeal swabs, were admitted from March 3, 2020, to July 10, 2020. Adult patients in the sepsis-induced acute respiratory distress syndrome cohort, defined by Sepsis III criteria receipt of invasive mechanical ventilation and a Pao2/Fio2 ratio less than 300 were admitted from December 12, 2006, to February 26, 2019. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. We evaluated serial serum albumin levels within 30 days after ICU admission in each cohort. We then examined the albumin progression trajectories, aligned at ICU admission time to test the relationship at a similar point in disease progression, in survivors and nonsurvivors. Albumin trajectory in all critically ill coronavirus disease 2019 patients show two distinct phases: phase I (deterioration) showing rapid albumin loss and phase II (recovery) showing albumin stabilization or improvement. Meanwhile, albumin recovery predicted clinical improvement in critical coronavirus disease 2019. In addition, we found a deterioration and recovery trends in survivors in the sepsis-induced acute respiratory distress syndrome cohort but did not find such two-phase trend in nonsurvivors. CONCLUSIONS:. The changes in albumin associated with coronavirus disease 2019 associated respiratory failure are transient compared with sepsis-associated acute respiratory distress syndrome and highlight the potential for recovery following a protracted course of severe coronavirus disease 2019.

Category: Midfoot/Forefoot; Sports Introduction/Purpose: Fractures of the fifth metatarsal occur in young, athletic populations and often result in sub-optimal clinical outcomes, even after surgical fixation. With such a high demand for decreased return to play in athletic populations, the development of intervention strategies which mitigate intrinsic and extrinsic risk factors of initial injury is important. Foot orthotics have been shown to decrease strain in the 2nd metatarsal. However, limited research has investigated the influence of intrinsic risk factors and the use of foot orthotics on fifth metatarsal strain. Therefore, the purpose of our study was to investigate the effect of foot orthotics and intrinsic risk factors on fifth metatarsal strain during cadaveric simulation. Methods: Ten specimens were loaded to simulate the stance phase of normal gait using a validated 6-degree of freedom robot with tendon actuators. Strain gauges were placed at the metaphyseal - diaphyseal junction (Zone II), and the proximal diaphysis (Zone III) to measure principal strain. Specimens were tested in a sneaker-only control condition and ten orthotic conditions, which include combinations of a commercial orthotic insole, three plates, and two foam wedges (Figure 1A). The average peak strain from three simulations were recorded for each orthotic condition. Relevant intrinsic factors were recorded from reconstructions of axially loaded computed tomography scans. A two-way repeated measures ANOVA was conducted to determine the effect of orthotic conditions on fifth metatarsal strains, with significantly correlated intrinsic factors included as covariates. Tukey-Kramer post-hoc analysis with a Bonferroni correction was used to analyze differences between individual orthotic conditions and main effects of components. Results: Metatarsus adductus angle, 4-5 intermetatarsal angle, and Meary’s angle (R2= 0.944; p

Background. Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a common treatment for patients suffering from different hematological disorders. Allo-HCT in combination with hematopoietic stem cell (HSC) gene therapy is considered a promising treatment option for millions of patients with HIV+ and acute myeloid leukemia. Most currently available HSC gene therapy approaches target CD34-enriched cell fractions, a heterogeneous mix of mostly progenitor cells and only very few HSCs with long-term multilineage engraftment potential. As a consequence, gene therapy approaches are currently limited in their HSC targeting efficiency, very expensive consuming huge quantities of modifying reagents, and can lead to unwanted side effects in nontarget cells. We have previously shown that purified CD34+CD90+CD45RA− cells are enriched for multipotent HSCs with long-term multilineage engraftment potential, which can reconstitute the entire hematopoietic system in an autologous nonhuman primate transplant model. Here, we tested the feasibility of transplantation with purified CD34+CD90+CD45RA− cells in the allogeneic setting in a nonhuman primate model. Methods. To evaluate the feasibility of this approach, CD34+CD90+CD45RA− cells from 2 fully major histocompatibility complex-matched, full sibling rhesus macaques were sort-purified, quality controlled, and transplanted. Engraftment and donor chimerism were evaluated in the peripheral blood and bone marrow of both animals. Results. Despite limited survival due to infectious complications, we show that the large-scale sort-purification and transplantation of CD34+CD90+CD45RA− cells is technically feasible and leads to rapid engraftment of cells in bone marrow in the allogeneic setting and absence of cotransferred T cells. Conclusions. We show that purification of an HSC-enriched CD34+ subset can serve as a potential stem cell source for allo-HCTs. Most importantly, the combination of allo-HCT and HSC gene therapy has the potential to treat a wide array of hematologic and nonhematologic disorders.

Can people 'see' previously unnoticed properties in objects that they visualize, or are they locked into the organization of the pattern that was encoded during perception? To answer this question, we first asked a group to describe letters of the alphabet and found that some properties (such as the presence of a diagonal line) are often mentioned, whereas others (such as symmetry) are rarely if ever mentioned. Then we showed not only that other participants could correctly detect both kinds of properties in visualized letters, but also that the relative differences in the ease of detecting these two types of properties are highly similar in perception (when the letters are actually visible) and imagery (when the letters are merely visualized). These findings provide support for the view that images can be reinterpreted in ways much like what occurs during perception and speak to the wider issue of the long-standing debate about the format of mental images. [ABSTRACT FROM AUTHOR]

Acute chest syndrome (ACS) is one of the most common causes of death and hospitalization among patients with a sickle hemoglobinopathy. The clinical presentation is characterized by the appearance of a new infiltrate on a chest radiograph, with 1 or more new symptoms, including fever, cough, chest pain, and dyspnea. Additional findings include leukocytosis, hypoxemia, and auscultatory signs of consolidation. The differential diagnosis includes pneumonia, pulmonary infarction, fat embolism syndrome, pulmonary edema, and bone infarction. Treatment of ACS involves supportive care, empiric antibiotic therapy, and red blood cell transfusion when indicated. The decision of whether to use simple or exchange transfusions depends on the severity of illness and the risk of acute respiratory failure. Currently, hydroxyurea is the only FDA-approved drug designated as a preventive therapy. [ABSTRACT FROM AUTHOR]

Objective: This study was undertaken to determine the incidence of catheter-associated infection after radical hysterectomy and to evaluate the role of prophylactic antibiotics in these patients.Study Design: A 4-year retrospective review of 102 women undergoing radical hysterectomy for cervical or endometrial cancer was performed. Clinical data were abstracted and analyzed with chi(2) and t tests.Results: Catheter-associated infection was observed in 11% (12 of 102) and was not altered by the administration of prophylactic antibiotics (11.1% vs 11.8%, P=.95). Of the 12 women who had infection, 11 were treated as outpatients, and 1 patient required admission for pyelonephritis. Patient age, comorbid medical conditions, class of radical hysterectomy, perioperative complications, operative time, blood loss, catheter type, duration of catheterization, and length of hospitalization had no effect on the development of catheter-associated infection.Conclusion: The incidence of catheter-associated infection in women requiring prolonged catheterization after radical hysterectomy is relatively low. Withholding prophylactic antibiotics from these patients is a reasonable clinical option. [ABSTRACT FROM AUTHOR]

Objective: The study was undertaken to report our experience with vaginectomy and pelvic herniorrhaphy for vaginal prolapse.Study Design: This was an observational study of patients undergoing vaginectomy (n=41) or hysterovaginectomy (n=13) for stage III/IV vaginal prolapse. Morbidity was compared with cohorts who had undergone transvaginal repair of prolapse, by using the Mann-Whitney U test.Results: Morbidity did not differ significantly (estimated blood loss) between the vaginectomy and hysterovaginectomy groups. There were no recurrent hernias (6-56 months). Operative time, estimated blood loss, and day of discharge were significantly greater for the posthysterectomy prolapse group compared with the vaginectomy group. Operative time was significantly greater for the uterovaginal prolapse group versus the hysterovaginectomy group.Conclusions: Vaginectomy with or without hysterectomy with pelvic herniorrhaphy is associated with a low rate of morbidity in a high-risk patient population. Hysterovaginectomy is not associated with a clinically significant difference in morbidity over vaginectomy alone. Vaginectomy with or without hysterectomy should be offered as a surgical option to selected patients with severe genital prolapse. [ABSTRACT FROM AUTHOR]

OBJECTIVE: This article describes the simulation of robotically assisted hysterectomy utilizing the porcine model. STUDY DESIGN: Utilizing 3 domestic pigs, a technique for robotically assisted hysterectomy was developed. An edited video clip of the model was assessed by 6 gynecological surgeons. RESULTS: The steps of the operation are described in detail and are shown in a video clip. Overall the procedure simulated that done in the human both anatomically and surgically. Some of the evaluators rated the identification of the cervicovesical junction to be more difficult and division of the paracervical ligaments to be relatively easier in the model. CONCLUSION: Reported here is a technique for robotically assisted hysterectomy in the domestic pig that may be useful for training purposes. [ABSTRACT FROM AUTHOR]

Background: Cervical stump malignancies are an uncommon finding post subtotal hysterectomy. Tumors arise from a primary cervical origin with an incidence of 1-5%. Other described malignancies can include uterine origin, ovarian origin or as metastases from another primary site. A uterine primary is an extremely rare entity and can result from remnant endometrial tissue at the stump apex., Case: 70yo female with a history of remote supracervical hysterectomy for benign indication who presented with postmenopausal spotting. Endocervical curettage of the endocervical stump revealed a grade 2 endometrioid endometrial adenocarcinoma. She was taken to the operating for a robotic radical stump trachelectomy and sentinel lymph node dissection., Conclusions: The surgical video delineates key surgical steps of robotic radical stump trachelectomy including robotic port placement and injection of ICG dye, adhesiolysis and restoration of normal anatomy, opening of the pelvic spaces and exposure of the retroperitoneum, identification and excision of pelvic sentinel lymph nodes, bladder dissection, ureterolysis and ligation of uterine remnant, ureteric tunnel dissection and mobilization of parametrial wing, delineation of a vaginal margin, colpotomy and specimen removal, and vaginal cuff closure., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Inc.)

Objective: We sought to document current surgical practices among gynecologic oncologists in the United States., Methods: In March/April 2020, we conducted a cross-sectional survey among members of the Society of Gynecologic Oncology to identify gynecologic oncology practice trends in the United States. The survey collected demographic data and queried participants on types of surgical procedures performed and chemotherapy use. Univariant and multivariant analyses were used to evaluate the association between surgeon practice type, region of practice, working with gynecologic oncology fellows, time in practice, and dominant surgical modality of practice on performance of specific procedures., Results: Among 1199 gynecologic oncology surgeons who were emailed the survey, 724 completed the survey (60.4% response rate). Of these respondents, 170 (23.5%) were within 6 years of fellowship graduation, 368 (50.8%) identified as female; and 479 (66.2%) worked in an academic setting. Surgeons who worked with gynecologic oncology fellows were more likely to perform bowel surgery, upper abdominal surgery, complex upper abdominal surgery, and prescribe chemotherapy. Surgeons who were ≥ 13 years out from fellowship graduation were more likely to perform bowel surgery and complex abdominal surgery and less likely to prescribe chemotherapy and perform sentinel lymph node dissections (P < 0.05)., Conclusions: These findings highlight the variation in surgical procedures performed by gynecologic oncologists in the United States. These data support that there are practice variations that would benefit from further investigation., Competing Interests: Declaration of Competing Interest Outside the submitted work, D. Chi reports personal fees from Apyx Medical, Verthermia Inc., Biom ‘Up, and AstraZeneca, as well as recent or current stock/options ownership of Apyx Medical, Verthemia, Intuitive Surgical, Inc., TransEnterix, Inc., Doximity, Moderna, and BioNTech SE. A. Iasonos reports consulting fees from Mylan. The other authors do not have potential conflicts of interest to declare., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Objective: To determine the effect of distance to closest negative margin on survival after pelvic exenteration (PE)., Methods: In this retrospective analysis of PE at Moffitt Cancer Center from 2000 to 2019, baseline characteristics, clinical details, and outcomes were ascertained. Distance to closest negative margin was measured. Close and distant negative margins were defined as <3 mm and ≥3 mm from malignancy to nearest surgical margin, respectively. Overall survival (OS) and progression-free survival (PFS) were determined, and Kaplan-Meier curves were compared. Cox proportional hazards regression was used to examine the association of margin status with OS and PFS., Results: Of 124 PEs with malignancy, 80 (64.5%) had negative margins. Median survival was 62 (95% confidence interval [CI] 27-70) months for negative and 21 (95% CI 15-29) months for positive margins. Of 76 with negative margins and documented margin length, 26 had close and 50 had distant margins. Median survival was 32 (95% CI 14-62) months for close and 111 (95% CI 42-166) months for distant margins. Distant margins were associated with improved OS (p = 0.0054) and PFS (p = 0.0099) compared to close margins. After adjusting for other prognostic factors, patients with distant margins had significantly decreased risk of all-cause mortality (HR 0.39, 95% CI 0.19-0.78; p = 0.008) and progression (HR 0.48, 95% CI 0.23-0.99; p = 0.04) compared to positive margins. No significant differences in OS or PFS were observed between close and positive margins. This survival benefit remained among those with cervical cancer. Median survival in this cohort was 34.1 (95% CI 2.0-69.8) months for close and 165.7 (95% CI 24.5-165.7) for distant margins., Conclusions: Distant margins following PE are associated with improved OS and PFS compared to close margins., Competing Interests: Declaration of Competing Interest J.C. reports compensation for speakership, advisory, and consulting roles from AstraZeneca, Seagen, and Cigna/CareCore, Medtronic PLC, all outside the submitted work. R.M.W. reports compensation for advisory and consulting roles for Merck, Genentech, Ovation Diagnostics, GSK/Tesaro, Clovis, AstraZeneca, Mersana, Abbvie, Legend Biotech, Regeneron, Seagen/Seattle Genetics, Sonnet Biotherapeutics, Shattuck Labs, Novocure, Eisai, and Immunogen, all outside the submitted work., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Background: In 2017, 45% of rural adults reported being directly impacted by the opioid epidemic. While research on the experiences of those using prescription opioids in rural communities is increasing, less is known about a unique sub-population who may have high rates of exposure: rural agricultural workers. The purpose of this study was to explore the prevalence and perceptions related to prescription opioids among rural producers and farmworkers. Methods: A questionnaire was mailed in spring 2019 and spring 2020 to rural residents living in one of two agricultural-based states in the Upper Midwest. Individuals were eligible to participate if any member of their family was involved in the agricultural industry. A total of 1116 questionnaires were returned for a 27.9% response rate. Results: Participants were 68.1 years old on average. The majority identified as white, male, and married. Prescription opioid use was found in 8.2% of households currently, and 15.7% in the past year. There were no gender differences in prevalence of use, but women and older individuals reported significantly more perceived risk than men and younger individuals. Nearly half used alternative pain management, and received most information about prescription opioids from the radio (65.5%) and newsletters (13.5%). Conclusions. Despite their elevated age and working in an occupation at high risk of injury and chronic pain, study participants reported few opioid prescriptions and moderate use of alternative pain management. Perceived risk of prescription opioids may explain low prevalence. Outreach efforts that increase access to healthcare services and alternative pain management treatments for agricultural workers may mitigate the experience of chronic pain that can interfere with their overall quality of life.

Objective: To describe the incidence, complications, and trends associated with ureteral surgeries on a gynecologic oncology service in the context of a fellowship training program over a 24-year period., Methods: We conducted a retrospective cohort analysis of ureteral surgeries by gynecologic oncologists at either Moffitt Cancer Center or Tampa General Hospital from 1997 to 2020. Patient characteristics, predisposing factors, location and type of injury, repair method, postoperative management and complications were abstracted from the medical record. The recent cohort (2005-2020) was compared to our prior series (1997-2004)., Results: Eighty-eight cases were included. The average number of ureteral surgeries per year decreased from 5.75 (1997-2004) to 2.63 (2005-2020). Of 46 iatrogenic injuries, 45 were recognized and repaired intraoperatively. Ureteral transection was the most common type (85% [39 of 46]) and the distal 5 cm was the most common location of injury (63% [29 of 46]). Ureteroneocystostomy was the most common method of repair (83% [73 of 88]). Postoperative management, including stenting and imaging, has not changed significantly. Length of urinary catheter usage decreased in the recent cohort without associated complications. Five patients had major postoperative complications and 4 involved the urinary tract. Of those with follow-up, 96% (66 of 69) of ureteroneocystostomies and 75% (9 of 12) of ureteroureterostomies had radiologically normal urinary tracts., Conclusions: Ureteral surgery is necessary in the case of injury or involvement with invasive disease. There has been a decrease in number of procedures. Ureteroneocystostomy has remained the most common method of reconstruction for both injury and resection with acceptable postoperative complication rates., Competing Interests: Declaration of Competing Interest The authors report no conflicts of interest., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Injury of the inferior vena cava is an infrequent but serious complication of paraaortic lymphadenectomy. Training in the management of this injury might be enhanced through animate simulation. Our objective was to assess a simulated animal model for training in intraoperative management of inferior vena cava injury in the context of robotic paraaortic lymphadenectomy. We used a female domestic pig to create an injury of the inferior vena cava, which was then managed two ways with robotically assisted surgery. Edited videos of the two models were assessed by 32 senior learners and 23 attending faculty. The assessments included key competencies and domains of fidelity. A scale of poor, fair, or good was utilized. The injury and management simulated those seen in humans, both anatomically and surgically, although deficiencies were noted. Specifically, a reduced rapidity of bleeding and a related greater ease of control contributed to lower ratings for some aspects of fidelity. Fidelity and addressing the key competency of suture repair also received some lower ratings, particularly from vascular surgeons and their trainees. The porcine model for simulation of inferior vena cava injury during robotically assisted paraaortic lymphadenectomy may be useful for training purposes.

The purpose of this paper is to review the surgical care related to training in gynecologic oncology, from past, present and future perspectives. A marked decline in the incidence of cervical cancer as well as improvements in radiation therapy have led to a reduction in the numbers of radical hysterectomies and exenterations being performed. Utilization of neoadjuvant chemotherapy is reducing the extent of cytoreductive operations, including intestinal surgery. The incorporation of sentinel lymphatic mapping has reduced the number of pelvic, paraaortic and inguinal lymphadenectomies being performed. Coupled with these changes are other factors limiting time for surgical training including an explosion in targeted anticancer therapies and more individualized options beyond simple cytotoxic therapy. With what is likely to be a sustained impact on training, gynecologic oncologists will still provide a broad range of care for women with gynecologic cancer but may be quite limited in surgical scope and rely on colleagues from other surgical disciplines. Enhancement of surgical training by off-service rotations, simulation, attending advanced surgical training courses and/or a longer duration of training are currently incorporated into some programs. Programs must ensure that fellows take full advantage of the clinical materials available, particularly those related to the potential deficiencies described. Changing required research training to an additional elective year could also be considered. Based on the perspectives noted, we believe it is time for our subspecialty to reevaluate its scope of surgical training and practice., Competing Interests: Declaration of competing interest The authors of this paper report that they have no conflicts of interest related to any of the content of this manuscript., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Introduction: To evaluate clinical outcomes, pattern of failure, and toxicity after high-dose intensity-modulated radiation therapy (IMRT) for advanced vulvar cancer., Methods: In this IRB approved retrospective study, the charts of women with histologically confirmed, non-metastatic vulvar cancer consecutively treated at our institution from 2012 to 2018 were reviewed to identify patients that received high-dose IMRT with curative intent. The treatment compliance, toxicities, and patterns of failure were investigated. Actuarial local, regional and distant recurrence and survival were estimated using Kaplan-Meier method and compared using log rank test., Results: Twenty-six patients were identified, 23 were unresectable, and 3 refused surgery. Fifteen patients (58%) had inguinal node metastases; 10(38%) had pelvic node metastases. Elective surgical staging of groins was performed in 9-patients. Median tumor dose was 65.4Gy. Concurrent platinum-based chemotherapy was administered in 22(84.6%) patients. Complete response (CR) was achieved in 21/26 (80.7%) patients. Five patients had persistent disease following treatment and one sustained recurrence 5-months following radiotherapy. All persistent or recurrent disease occurred inside the irradiated volume. Median follow-up was 19 months (3-52 months). Actuarial 1-year local, regional and distant controls were 72.4%, 85.4%, and 86%, respectively. One and 2-year overall survivals were 91% and 62%, respectively. Complete response at 3-months was a strong predictor for overall survival (1-yr OS 73% vs 27%, HR 7.1 (95% CI 1.2-44); p = 0.01). Lymph node metastases adversely affected overall survival (2-yr OS 49% vs. 83%, p = 0.09). Grade 3-4 late urinary and soft-tissue toxicity was seen in 5 patients. Tumor doses >66 Gy (p = 0.03) and prior pelvic radiotherapy (p = 0.002) predicted grade 3-4 toxicity., Conclusion: High-dose IMRT for vulvar cancer achieves high rates of local control with acceptable dose dependent long-term toxicity., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Objective: To assess whether there were any significant changes in surgical training volume over the past 20 years that might have ramifications toward preparedness for practice., Methods: We used deidentified annual summaries of fellow case numbers for the academic years 1999 through 2018. Unpaired t-tests with Welch's correction were performed on all surgical categories for 10-year and 5-year periods., Results: The total number of hysterectomies performed each year did not change significantly. The percent of hysterectomies performed by minimally invasive surgery increased significantly starting in 2008. There was a significant decline in the number of radical hysterectomies conducted starting after 2004, which then remained stable. There was also a significant decline in the number of bowel resections/anastomoses performed by fellows on the gynecologic oncology services that occurred and stabilized during the same time frame. There were other significant trends associated with the introduction of minimally invasive techniques., Conclusion: The results of this study suggest the need to reevaluate fellowship training and/or the scope of surgical practice in gynecologic oncology., (Copyright © 2019 Elsevier Inc. All rights reserved.)