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717 results on '"Hoffman, Mitchel"'

3. A Summary of the Key Aspects of Perioperative Care for Women Undergoing MIS for Gynecological Oncology.

Author

Kotha, Rohini, Nama, Sharanya, Escher, Allan, and Hoffman, Mitchel

Subjects
VOMITING prevention, THROMBOEMBOLISM prevention, SURGICAL robots, ANEMIA, SMOKING cessation, HYPOTHERMIA, PREHABILITATION, VEINS, FLUID therapy, POSTOPERATIVE pain, MINIMALLY invasive procedures, PNEUMOPERITONEUM, FEMALE reproductive organ tumors, HYPERGLYCEMIA, SLEEP apnea syndromes, RETENTION of urine, POSTOPERATIVE period, SURGICAL site infections, PERIOPERATIVE care, ANESTHESIA, NAUSEA, PATIENT positioning
Abstract

A minimally invasive surgery (MIS) is the standard of care for surgical treatment in gynecological oncology. Robotic surgery is increasingly being used in this domain. Anesthetic considerations are related to the specific procedure, robotic approach per se, adjuvant chemotherapy, radiotherapy, and patient-specific concerns. Evidence-based practices encompass a balance of preoperative, intraoperative, and postoperative evidence-based goals. A summary of these key aspects of perioperative care for women undergoing MIS can enhance surgical outcomes in gynecological oncology. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Stoicism and Wellness in Medicine.

Author

Hoffman, Mitchel

Subjects
*TREATMENT of endometriosis, *SERIAL publications, *PSYCHOLOGICAL resilience, *HEALTH, *WORK-life balance, *DIGITAL divide, *SELF-control, *SEVERITY of illness index, *MEDICINE, *INTERGENERATIONAL relations
Published
2024
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19. Case Report: Durable complete pathologic response and organ preservation following ipilimumab and nivolumab for locally advanced primary vaginal mucosal melanoma

Author

Tarhini, Ahmad A., Hanayneh, Wissam B., Powers, John J., Segura, Carlos M. Moran, Conejo-Garcia, Jose R., Lam, Cesar A., Hakam, Ardeshir, and Hoffman, Mitchel S.

Subjects
Cancer Research, Oncology
Abstract

Optimal management of locally advanced vaginal mucosal melanoma is poorly understood because of its rarity and unique biology. Patients have a poor prognosis despite aggressive management approaches including pelvic exenteration and adjuvant radiation that carry major morbidities. We report a case of a patient in early 40’s who experienced complete pathologic response and organ preservation following immunotherapy consisting of 3 cycles of ipilimumab and nivolumab. Treatment was complicated by a high-grade immune mediated hepatitis that eventually resolved with immunosuppressive therapy. Immune monitoring studies utilizing vaginal tumor biopsies showed evidence of enhanced infiltration by CD3+/CD8+ cytotoxic T-cells and increased expression of MHC-I/PD-L1 within the tumor microenvironment following immunotherapy. The patient continues to be without evidence of disease recurrence by radiologic and gynecologic examinations with more than 2 years of follow up from the time of immunotherapy initiation. To our knowledge, this is the only case report in the literature of a patient with locally advanced vaginal mucosal melanoma experiencing a durable complete pathologic response and organ preservation following immune checkpoint blockade as the only treatment approach.

Published
2022

26. Enlarged Uterus

Author

Hoffman, Mitchel S., Spellacy, William N., Hoffman, Mitchel S., and Spellacy, William N.

Published
1995
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31. Prognostic features of endometrial cancer metastasis to the central nervous system

Author

Kuznicki, Michelle L., primary, Mallen, Adrianne, additional, Ha, Kristal, additional, McClung, Emily Clair, additional, Castaneda, Antonio V., additional, Cao, Biwei, additional, Fridley, Brooke L., additional, Chon, Hye Sook, additional, Chern, Jing Yi, additional, Hoffman, Mitchel, additional, Wenham, Robert M., additional, Matsuo, Koji, additional, and Shahzad, Mian M. K., additional

Published
2022
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41. Vaginal Evisceration Subsequent to Hysterectomy at a Major Cancer Center.

Author

Fermin, Oriana, Delgado, Arlin, Sarkar, Papri, Chern, Jing-Yi, Wenham, Robert, and Hoffman, Mitchel S.

Subjects
PREVENTION of surgical complications, VAGINAL diseases, SUTURING, VAGINAL hysterectomy, RETROSPECTIVE studies, ACQUISITION of data, SURGICAL wound dehiscence, RISK assessment, CATASTROPHIC illness, MEDICAL records, DISEASE risk factors
Abstract

Objective: This article describes the incidence, presentation, management, and outcome of posthysterectomy vaginal cuff evisceration over a 2-year timeperiod at a major cancer center. Materials and Methods: This was a retrospective chart review of patients who developed vaginal cuff evisceration after prior hysterectomy. The denominator of hysterectomies performed by the department between May 1, 2020 and April 30, 2022, was included in the analysis. The cases of vaginal evisceration were well-known to the practice. Results: Three women who had undergone hysterectomy during the 2-year timeperiod developed vaginal cuff evisceration. This incidence was 0.3%. All 3 women underwent surgical repair (1 with bowel resection) without subsequent complications. Conclusions: Vaginal evisceration is a rare complication of hysterectomy at a major cancer center. This report adds to the body of knowledge regarding diagnosis and management of this dramatic and life-threatening event. (J GYNECOL SURG 39:49) [ABSTRACT FROM AUTHOR]

Published
2023
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