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415 results on '"Hoffman, Brenda J."'

1. Effect of endoscopic submucosal dissection on histologic diagnosis in Barrett’s esophagus visible neoplasia

Author

Yang, Dennis, King, William, Aihara, Hiroyuki, Karasik, Michael S., Ngamruengphong, Saowanee, Aadam, Abdul Aziz, Othman, Mohamed O., Sharma, Neil, Grimm, Ian S., Rostom, Alaa, Elmunzer, B. Joseph, Jawaid, Salmaan A., Perbtani, Yaseen B., Hoffman, Brenda J., Akki, Ashwin S., Schlachterman, Alexander, Coman, Roxana M., Wang, Andrew Y., and Draganov, Peter V.

Published
2022
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2. Endoscopic Submucosal Dissection in North America: A Large Prospective Multicenter Study

Author

Draganov, Peter V., Aihara, Hiroyuki, Karasik, Michael S., Ngamruengphong, Saowanee, Aadam, Abdul Aziz, Othman, Mohamed O., Sharma, Neil, Grimm, Ian S., Rostom, Alaa, Elmunzer, B. Joseph, Jawaid, Salmaan A., Westerveld, Donevan, Perbtani, Yaseen B., Hoffman, Brenda J., Schlachterman, Alexander, Siegel, Amanda, Coman, Roxana M., Wang, Andrew Y., and Yang, Dennis

Published
2021
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3. Late Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial

Author

Cotton, Cary C, Wolf, W Asher, Overholt, Bergein F, Li, Nan, Lightdale, Charles J, Wolfsen, Herbert C, Pasricha, Sarina, Wang, Kenneth K, Shaheen, Nicholas J, Group, AIM Dysplasia Trial, Sampliner, Richard E, Fleischer, David E, Sharma, Virender K, Eisen, Glenn M, Fennerty, M Brian, Hunter, John G, Bronner, Mary P, Goldblum, John R, Bennett, Ana E, Mashimo, Hiroshi, Rothstein, Richard I, Gordon, Stuart R, Edmundowicz, Steven A, Muthusamy, V Raman, Chang, Kenneth J, Kimmey, Michael B, Spechler, Stuart J, Siddiqui, Ali A, Souza, Rhonda F, Infantolino, Anthony, Dumot, John A, Falk, Gary W, Jobe, Blair A, Hawes, Robert H, Hoffman, Brenda J, Sharma, Prateek, and Chak, Amitabh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Digestive Diseases, Cancer, Oral and gastrointestinal, Aged, Barrett Esophagus, Catheter Ablation, Disease Progression, Esophagus, Female, Follow-Up Studies, Humans, Incidence, Kaplan-Meier Estimate, Male, Metaplasia, Middle Aged, Mucous Membrane, Population Surveillance, Prospective Studies, Recurrence, Time Factors, AIM Dysplasia Trial Group, HGD, High Grade Dysplasia, LGD, Long-term Outcome, Low Grade Dysplasia, Prognostic Factor, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsThe goal of treatment for Barrett's esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). The long-term durability of CEIM has not been well characterized, so the frequency and duration of surveillance are unclear. We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) trial.MethodsParticipants for the AIM Dysplasia trial (18-80 years old) were recruited from 19 sites in the United States and had endoscopic evidence of non-nodular dysplastic BE ≤8 cm in length. Subjects (n = 127) were randomly assigned (2:1 ratio) to receive either RFA (entire BE segment ablated circumferentially) or a sham endoscopic procedure; patients in the sham group were offered RFA treatment 1 year later, and all patients were followed for 5 years. We collected data on BE recurrence (defined as intestinal metaplasia in the tubular esophagus) and dysplastic BE recurrence among patients who achieved CEIM. We constructed Kaplan-Meier estimates and applied parametric survival analysis to examine proportions of patients without any recurrence and without dysplastic recurrence.ResultsOf 127 patients in the AIM Dysplasia trial, 119 received RFA and met inclusion criteria. Of those 119, 110 (92%) achieved CEIM. Over 401 person-years of follow-up (mean, 3.6 years per patient; range, 0.2-5.8 years), 35 of 110 (32%) patients had recurrence of BE or dysplasia, and 19 (17%) had dysplasia recurrence. The incidence rate of BE recurrence was 10.8 per 100 person-years overall (95% CI, 7.8-15.0); 8.3 per 100 person-years among patients with baseline low-grade dysplasia (95% CI, 4.9-14.0), and 13.5 per 100 person-years among patients with baseline high-grade dysplasia (95% CI 8.8-20.7). The incidence rate of dysplasia recurrence was 5.2 per 100 person-years overall (95% CI 3.3-8.2); 3.3 per 100 person-years among patients with baseline low-grade dysplasia (95% CI 1.5-7.2), and 7.3 per 100 person-years among patients with baseline high-grade dysplasia (95% CI 4.2-12.5). Neither BE nor dysplasia recurred at a constant rate. There was a greater probability of recurrence in the first year following CEIM than in the following 4 years combined.ConclusionsIn this analysis of prospective cohort data from the AIM Dysplasia trial, we found BE to recur after CEIM by RFA in almost one third of patients with baseline dysplastic disease; most recurrences occurred during the first year after CEIM. However, patients who achieved CEIM and remained BE free at 1 year after RFA had a low risk of BE recurrence. Studies are needed to determine when surveillance can be decreased or discontinued; our study did not identify any BE or dysplasia recurrence after 4 years of surveillance.

Published
2017

4. Phase 2 Trial of Induction Gemcitabine, Oxaliplatin, and Cetuximab Followed by Selective Capecitabine-Based Chemoradiation in Patients With Borderline Resectable or Unresectable Locally Advanced Pancreatic Cancer

Author

Esnaola, Nestor F, Chaudhary, Uzair B, O'Brien, Paul, Garrett-Mayer, Elizabeth, Camp, E Ramsay, Thomas, Melanie B, Cole, David J, Montero, Alberto J, Hoffman, Brenda J, Romagnuolo, Joseph, Orwat, Kelly P, and Marshall, David T

Subjects
Rare Diseases, Cancer, Pancreatic Cancer, Patient Safety, Clinical Trials and Supportive Activities, Digestive Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.5 Radiotherapy and other non-invasive therapies, 6.1 Pharmaceuticals, Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Capecitabine, Chemoradiotherapy, Deoxycytidine, Drug Administration Schedule, Female, Fluorouracil, Humans, Induction Chemotherapy, Male, Middle Aged, Organoplatinum Compounds, Oxaliplatin, Pancreatic Neoplasms, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Gemcitabine, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeTo evaluate, in a phase 2 study, the safety and efficacy of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer (BRPC or LAPC, respectively).Methods and materialsPatients received gemcitabine and oxaliplatin chemotherapy repeated every 14 days for 6 cycles, combined with weekly cetuximab. Patients were then restaged; "downstaged" patients with resectable disease underwent attempted resection. Remaining patients were treated with chemoradiation consisting of intensity modulated radiation therapy (54 Gy) and concurrent capecitabine; patients with borderline resectable disease or better at restaging underwent attempted resection.ResultsA total of 39 patients were enrolled, of whom 37 were evaluable. Protocol treatment was generally well tolerated. Median follow-up for all patients was 11.9 months. Overall, 29.7% of patients underwent R0 surgical resection (69.2% of patients with BRPC; 8.3% of patients with LAPC). Overall 6-month progression-free survival (PFS) was 62%, and median PFS was 10.4 months. Median overall survival (OS) was 11.8 months. In patients with LAPC, median OS was 9.3 months; in patients with BRPC, median OS was 24.1 months. In the group of patients who underwent R0 resection (all of which were R0 resections), median survival had not yet been reached at the time of analysis.ConclusionsThis regimen was well tolerated in patients with BRPC or LAPC, and almost one-third of patients underwent R0 resection. Although OS for the entire cohort was comparable to that in historical controls, PFS and OS in patients with BRPC and/or who underwent R0 resection was markedly improved.

Published
2014

5. Late Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial

Author

Sampliner, Richard E., Fleischer, David E., Sharma, Virender K., Eisen, Glenn M., Fennerty, M. Brian, Hunter, John G., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Mashimo, Hiroshi, Rothstein, Richard I., Gordon, Stuart R., Edmundowicz, Steven A., Muthusamy, V. Raman, Chang, Kenneth J., Kimmey, Michael B., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Dumot, John A., Falk, Gary W., Jobe, Blair A., Hawes, Robert H., Hoffman, Brenda J., Sharma, Prateek, Chak, Amitabh, Cotton, Cary C., Wolf, W. Asher, Overholt, Bergein F., Li, Nan, Lightdale, Charles J., Wolfsen, Herbert C., Pasricha, Sarina, Wang, Kenneth K., and Shaheen, Nicholas J.

Published
2017
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6. Contributors

Author

Agarwal, Mitali, Alsabbagh, Mohammed Eyad, Aswath, Ganesh, Bacon, Bruce Raymond, Bader, Geoffrey, Bang, Ji Young, Bhamidimarri, Kalyan Ram, Bhasin, Devina, Birkness-Gartman, Jacqueline, Guzmán, Gabriel A. Bolaños, Bower, Richard, Bradley, Mathew J., Brown, Landon, Brown, Roderick Seth, Burger, Cassandra, Burke, Carol Ann, Cappell, Mitchell S., Carey, William, Chang, Karen, Cheatham, Joseph G., Chong, Bradford Jin, Clayton, Steven, Cleaver, David, Coté, Gregory A., De Witte, Anton Jordan, Deshpande, Amar R., Di Palma, Jack A., Dryden, Gerald, Dulaney, David T., Dunbar, Trevor, Eaton, John E., Falloon, Katherine, Farraye, Francis A., Fox, Michael G., Gancayco, John, Ghafoor, Adil, Goff, John S., Golla, Meghana, Han, Samuel, Harrison, Stephen A., Hennrikus, William P., Herrera, Jorge L., Hoffman, Brenda J., Hujoel, Isabel A., Jacobs, John W., John, Savio, Johnston, Zachary, Kaliney, Ryan, Kayali, Zeid, Kinnucan, Jami A., Kondo, Kimi L., Korus, Heather, Krishnan, Prashant Vasanth, Kuhn, Kristine A., Kulkarni, Anand V., Laczek, Jeffrey, Lai, Samuel H., LaPorta, Anthony J., Lashner, Bret A., Latanski, James, Lee, John W., Lee, Linda S., Lee, Mike H., Lee, Yoo Jin, Lembo, Anthony, Leung, Kenneth, Macaron, Carole, Mannon, Peter, Marchak, Katherine S., McCarter, Martin D., McNally, Peter R., Melmed, Gil Y., Mertz, Andrew T., Michaels, Alex D., Moran, Robert, Moyer, Amber M., Mukherjee, Rupa, Nguyen, Nathalie, Oshima, Kiyoko, Pappas, Theodore N., Patel, Anish, Patel, Dhyanesh A., Polanco, Nathalie A. Pena, Penninti, Pranav, Peter, Shajan, Platt, Kevin D., Proksell, Siobhan, Rangan, Vikram, Rao, Satish S.C., Reddy, K. Rajender, Rice, Michael D., Riddle, Mark D., Rouphael, Carol, Russo, Mark W., Saag, Michael, Saffouri, George, Salvo, Rebecca, Schiller, Lawrence R., Sempokuya, Tomoki, Shah, Raj J., Shrestha, Roshan, Sill, Andrew P., Singal, Ashwani K., Spencer, Chad M., Spitzer, Holly V., Surawicz, Christina M., Tayal, Shalini, Taylor, Zachary A., Thélin, Camille S., Torres, Dawn M., Trotter, James F., Vakil, Nimish, Varadarajulu, Shyam, Vindigni, Stephen M., Vogel, Jon D., Walker, Lisa, Westhoff, John, White, Clemence C., Wideroff, Gina A., Wilcox, C. Mel, Worlton, Tamara J., Young, Patrick E., and Zimmer, Sarah

Published
2025
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10. Durability of Radiofrequency Ablation in Barrett's Esophagus With Dysplasia

Author

Shaheen, Nicholas J., Overholt, Bergein F., Sampliner, Richard E., Wolfsen, Herbert C., Wang, Kenneth K., Fleischer, David E., Sharma, Virender K., Eisen, Glenn M., Fennerty, M. Brian, Hunter, John G., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Mashimo, Hiroshi, Rothstein, Richard I., Gordon, Stuart R., Edmundowicz, Steven A., Madanick, Ryan D., Peery, Anne F., Muthusamy, V. Raman, Chang, Kenneth J., Kimmey, Michael B., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Dumot, John A., Falk, Gary W., Galanko, Joseph A., Jobe, Blair A., Hawes, Robert H., Hoffman, Brenda J., Sharma, Prateek, Chak, Amitabh, and Lightdale, Charles J.

Published
2011
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17. Radiofrequency Ablation in Barrettʼs Esophagus with Dysplasia

Author

Shaheen, Nicholas J., Sharma, Prateek, Overholt, Bergein F., Wolfsen, Herbert C., Sampliner, Richard E., Wang, Kenneth K., Galanko, Joseph A., Bronner, Mary P., Goldblum, John R., Bennett, Ana E., Jobe, Blair A., Eisen, Glenn M., Fennerty, Brian M., Hunter, John G., Fleischer, David E., Sharma, Virender K., Hawes, Robert H., Hoffman, Brenda J., Rothstein, Richard I., Gordon, Stuart R., Mashimo, Hiroshi, Chang, Kenneth J., Muthusamy, Raman V., Edmundowicz, Steven A., Spechler, Stuart J., Siddiqui, Ali A., Souza, Rhonda F., Infantolino, Anthony, Falk, Gary W., Kimmey, Michael B., Madanick, Ryan D., Chak, Amitabh, and Lightdale, Charles J.

Published
2009
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28. Modeling rectal cancer to advance neoadjuvant precision therapy

Author

Janakiraman, Harinarayanan, primary, Zhu, Yun, additional, Becker, Scott A., additional, Wang, Cindy, additional, Cross, Ashley, additional, Curl, Emily, additional, Lewin, David, additional, Hoffman, Brenda J., additional, Warren, Graham W., additional, Hill, Elizabeth G., additional, Timmers, Cynthia, additional, Findlay, Victoria J., additional, and Camp, Ernest R., additional

Published
2020
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30. 639 DURABILITY OF SUCCESSFUL ERADICATION OF BARRETT’ ESOPHAGUS WITH LIQUID NITROGEN SPRAY CRYOTHERAPY: RESULTS OF A U.S. MULTICENTER REGISTRY

Author

Eluri, Swathi, primary, Kaul, Vivek, additional, McKinley, Matthew, additional, Pleskow, Douglas K., additional, Nishioka, Norman S., additional, Hoffman, Brenda J., additional, Nieto, Jose, additional, Tsai, Franklin, additional, Coyle, Walter J., additional, Kothari, Shivangi, additional, Joshi, Virendra, additional, Dumot, John A., additional, Greenwald, Bruce D., additional, and Shaheen, Nicholas J., additional

Published
2019
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31. Sa1137 – Liquid Nitrogen Spray Cryotherapy Eradicates Dysplasia in 87% and Intestinal Metaplasia in 65% of Patients with Barrett's Esophagus: Results of a U.S. Multicenter Registry

Author

Eluri, Swathi, primary, Kaul, Vivek, additional, McKinley, Matthew, additional, Pleskow, Douglas K., additional, Tsai, Franklin, additional, Nieto, Jose, additional, Nishioka, Norman S., additional, Hoffman, Brenda J., additional, Joshi, Virendra, additional, Fernando, Hiran C., additional, Habr, Fadlallah, additional, Dumot, John A., additional, Litle, Virginia, additional, Kothari, Shivangi, additional, Coyle, Walter J., additional, Greenwald, Bruce D., additional, and Shaheen, Nicholas J., additional

Published
2019
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32. EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases

Author

tenBerge, Jorgen, Hoffman, Brenda J., Hawes, Robert H., van Enckevort, Conny, Giovannini, Marc, Erickson, Richard A., Catalano, Marc F., Fogel, Roberto, Mallery, Shawn, Faigel, Douglas O., Ferrari, Angelo P., Waxman, Irving, Palazzo, Larent, Ben-Menachem, Tamir, Jowell, Paul S., McGrath, Kevin M., Kowalski, Thomas E., Nguyen, Cuong C., Wassef, Wahid Y., Yamao, Keiji, Chak, Amitabh, Greenwald, Bruce D., Woodward, Timothy A., Vilmann, Peter, Sabbagh, Luis, and Wallace, Michael B.

Published
2002
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47. Su1126 LIQUID NITROGEN SPRAY CRYOTHERAPY IS EFFECTIVE FOR BARRETT'S ESOPHAGUS-ASSOCIATED INTRAMUCOSAL ADENOCARCINCOMA: RESULTS FROM A MULTICENTER U.S. REGISTRY

Author

Ramay, Fariha H., primary, Kaul, Vivek, additional, Shaheen, Nicholas J., additional, Pleskow, Douglas K., additional, Litle, Virginia, additional, Fernando, Hiran C., additional, Nishioka, Norman S., additional, Nieto, Jose, additional, McKinley, Matthew, additional, Tsai, Franklin, additional, Coyle, Walter J., additional, Hoffman, Brenda J., additional, Joshi, Virendra, additional, and Greenwald, Bruce D., additional

Published
2018
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48. Tu1147 LIQUID NITROGEN SPRAY CRYOTHERAPY FOR PALLIATION OF INVASIVE ESOPHAGEAL CARCINOMA: RESULTS FROM A MULTICENTER U.S. REGISTRY

Author

Ramay, Fariha H., primary, Shaheen, Nicholas J., additional, Kaul, Vivek, additional, Nieto, Jose, additional, Joshi, Virendra, additional, Litle, Virginia, additional, Fernando, Hiran C., additional, Fukami, Norio, additional, Hoffman, Brenda J., additional, Bizekis, Costas, additional, McKinley, Matthew, additional, Habr, Fadlallah, additional, Nishioka, Norman S., additional, Tsai, Franklin, additional, Coyle, Walter J., additional, Pleskow, Douglas K., additional, and Greenwald, Bruce D., additional

Published
2018
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