Search

Your search keyword '"Hoevenaar-Blom, Marieke"' showing total 150 results
Start Over Author "Hoevenaar-Blom, Marieke"
150 results on '"Hoevenaar-Blom, Marieke"'

1. Cognitive Testing in People at Increased Risk of Dementia Using a Smartphone App: The iVitality Proof-of-Principle Study

Author

Jongstra, Susan, Wijsman, Liselotte Willemijn, Cachucho, Ricardo, Hoevenaar-Blom, Marieke Peternella, Mooijaart, Simon Pieter, and Richard, Edo

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundSmartphone-assisted technologies potentially provide the opportunity for large-scale, long-term, repeated monitoring of cognitive functioning at home. ObjectiveThe aim of this proof-of-principle study was to evaluate the feasibility and validity of performing cognitive tests in people at increased risk of dementia using smartphone-based technology during a 6 months follow-up period. MethodsWe used the smartphone-based app iVitality to evaluate five cognitive tests based on conventional neuropsychological tests (Memory-Word, Trail Making, Stroop, Reaction Time, and Letter-N-Back) in healthy adults. Feasibility was tested by studying adherence of all participants to perform smartphone-based cognitive tests. Validity was studied by assessing the correlation between conventional neuropsychological tests and smartphone-based cognitive tests and by studying the effect of repeated testing. ResultsWe included 151 participants (mean age in years=57.3, standard deviation=5.3). Mean adherence to assigned smartphone tests during 6 months was 60% (SD 24.7). There was moderate correlation between the firstly made smartphone-based test and the conventional test for the Stroop test and the Trail Making test with Spearman ρ=.3-.5 (P

Published
2017
Full Text
View/download PDF

4. Adding ethnicity to cardiovascular risk prediction: External validation and model updating of SCORE2 using data from the HELIUS population cohort

Author

van Apeldoorn, Joshua A.N., Hageman, Steven H.J., Harskamp, Ralf E., Agyemang, Charles, van den Born, Bert-Jan H., van Dalen, Jan Willem, Galenkamp, Henrike, Hoevenaar-Blom, Marieke P., Richard, Edo, van Valkengoed, Irene G.M., Visseren, Frank L.J., Dorresteijn, Jannick A.N., and Moll van Charante, Eric P.

Published
2024
Full Text
View/download PDF

5. Prevention of dementia using mobile phone applications (PRODEMOS): a multinational, randomised, controlled effectiveness–implementation trial

Author

Witvliet, Patrick, Hoitink, Mart, van de Groep, Bram, Liu, Hongmei, Ge, Siqi, He, Mingyue, Li, Cancan, Jian, Xuening, Jiang, Bin, Sun, Haixin, Ru, Xiaojuan, Sun, Dongling, Lian, Tenghong, Zhang, Weijiao, Zhang, Wenjing, Qi, Jing, Li, Jinghui, Guan, Huiying, Luo, Dongmei, Zhang, Weijia, Yue, Hao, Zheng, Zijing, Zeng, Qiang, Yang, Huangdai, Tang, Yanyan, Tao, Tianqi, Song, Yan, Meng, Xiaosheng, Zhu, Sirui, Jia, Dongmei, Li, Mo, Li, Wenjie, Mu, Haiyan, Jiang, Wenjing, Gao, Wenchao, Hu, Yueqing, Wang, Guohua, Xu, Xizhu, Zhang, Yichun, Li, Dong, Zhang, Xiaoyu, Guo, Xiuhua, Ye, Xiaoyan, Wei, Xi, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Song, Manshu, Andrieu, Sandrine, Barnes, Linda, Birck, Cindy, Brooks, Rachael, Coley, Nicola, Eggink, Esmé, Georges, Jean, Hafdi, Melanie, van Gool, Willem A, Handels, Ron, Hou, Haifeng, Lyu, Jihui, Niu, Yixuan, Song, Libin, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Yu, Yueyi, Zhang, Jinxia, Zhang, Wei, Brayne, Carol, Wang, Wei, and Richard, Edo

Published
2024
Full Text
View/download PDF

6. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia

Author

Lee, Crystal ManYing, Woodward, Mark, Batty, G David, Beiser, Alexa S, Bell, Steven, Berr, Claudine, Bjertness, Espen, Chalmers, John, Clarke, Robert, Dartigues, Jean‐Francois, Davis‐Plourde, Kendra, Debette, Stéphanie, Di Angelantonio, Emanuele, Feart, Catherine, Frikke‐Schmidt, Ruth, Gregson, John, Haan, Mary N, Hassing, Linda B, Hayden, Kathleen M, Hoevenaar‐Blom, Marieke P, Kaprio, Jaakko, Kivimaki, Mika, Lappas, Georgios, Larson, Eric B, LeBlanc, Erin S, Lee, Anne, Lui, Li‐Yung, van Charante, Eric P Moll, Ninomiya, Toshiharu, Nordestgaard, Liv Tybjærg, Ohara, Tomoyuki, Ohkuma, Toshiaki, Palviainen, Teemu, Peres, Karine, Peters, Ruth, Qizilbash, Nawab, Richard, Edo, Rosengren, Annika, Seshadri, Sudha, Shipley, Martin, Singh‐Manoux, Archana, Strand, Bjorn Heine, Gool, Willem A, Vuoksimaa, Eero, Yaffe, Kristine, and Huxley, Rachel R

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Neurosciences, Dementia, Acquired Cognitive Impairment, Clinical Research, Nutrition, Neurodegenerative, Rare Diseases, Brain Disorders, Prevention, Aging, Obesity, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), 2.1 Biological and endogenous factors, Aetiology, Neurological, Cardiovascular, Adult, Aged, Anthropometry, Body Mass Index, Body Size, Body Weight, Dementia, Vascular, Female, Humans, Male, Middle Aged, Risk Factors, Thinness, Waist Circumference, Weight Gain, Weight Loss, Medical and Health Sciences, Psychology and Cognitive Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5-22.4 kg/m2 ), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2 ) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.

Published
2020

7. Diagnostic Accuracy of the Telephone Interview for Cognitive Status for the Detection of Dementia in Primary Care

Author

Abdulrahman, Herrer, Jansen, Eva, Hoevenaar-Blom, Marieke, van Dalen, Jan Willem, van Wanrooij, Lennard L., van Bussel, Emma, van Gool, Willem A., Richard, Edo, and van Charante, Eric P. Moll

Subjects
Dementia -- Diagnosis, Telemedicine -- Usage, Primary health care -- Methods, Health, Science and technology
Abstract

PURPOSE Cognitive diagnostic work-up in primary care is not always physically feasible, owing to chronic disabilities and/or travel restrictions. The identification of dementia might be facilitated with diagnostic instruments that are time efficient and easy to perform, as well as useful in the remote setting. We assessed whether the Telephone Interview for Cognitive Status (TICS) might be a simple and accurate alternative for remote diagnostic cognitive screening in primary care. METHODS We administered the TICS (range, 0-41) for 810 of 1,473 older people aged 84.5 (SD, 2.4) years. We scrutinized electronic health records for participants with TICS scores [less than or equal to] 30 and for a random sample of participants with TICS scores >30 for a dementia diagnosis using all data from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial for 8-12 years of follow-up. We used multiple imputation to correct for verification bias. RESULTS Of the 810 participants, 155 (19.1%) had a TICS score [less than or equal to] 30, and 655 (80.9%) had a TICS score >30. Electronic health records yielded 8.4% (13/154) dementia diagnoses for participants with TICS [less than or equal to] 30 vs none with TICS >30. Multiple imputation for TICS >30 yielded a median of 7/655 (1.1%; interquartile range, 5-8) estimated dementia cases. After multiple imputation, the optimal cutoff score was [less than or equal to] 29, with mean sensitivity 65.4%, specificity 87.8%, positive predictive value 11.9%, negative predictive value 99.0%, and area under the curve 77.4% (95% CI, 56.3%-90.0%). CONCLUSIONS In the present older population, the TICS performed well as a diagnostic screening instrument for excluding dementia and might be particularly useful when face-toface diagnostic screening is not feasible in family practice or research settings. The potential reach to large numbers of people at low cost could contribute to more efficient medical management in primary care. Ann Fam Med 2022;20:130-136. https://doi.org/10.1370/afm.2768, INTRODUCTION In recent decades, increasing emphasis has been placed on early intervention in the care and treatment of persons with dementia to help provide more efficient medical management and advanced [...]

Published
2022
Full Text
View/download PDF

11. Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial

Author

Richard, Edo, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Coley, Nicola, Barbera, Mariagnese, van der Groep, Abraham, Meiller, Yannick, Mangialasche, Francesca, Beishuizen, Cathrien B, Jongstra, Susan, van Middelaar, Tessa, Van Wanrooij, Lennard L, Ngandu, Tiia, Guillemont, Juliette, Andrieu, Sandrine, Brayne, Carol, Kivipelto, Miia, Soininen, Hilkka, and Van Gool, Willem A

Published
2019
Full Text
View/download PDF

12. Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison

Author

Kivipelto, Miia, Sindi, Shireen, Solomon, Alina, Andrieu, Sandrine, Coley, Nicola, Soininen, Hilkka, Rosenberg, Anna, Richard, Edo, van Middelaar, Tessa, Hartmann, Tobias, Brayne, Carol, van Gool, Pim, Moll van Charante, Eric, Beishuizen, Cathrien, Jongstra, Susan, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Ngandu, Tiia, Barbera, Mariagnese, Mangiasche, Francesca, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, Braynefor, Carol, Soulier, Alexandra, Steensma, Jaap, Igier, Valérie, and Eskelinen, Marjo

Published
2019
Full Text
View/download PDF

13. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Author

Richard, Edo, van Gool, Pim, van Charante, Eric Moll, Beishuizen, Cathrien, Jongstra, Susan, van Middelaar, Tessa, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Soininen, Hilkka, Ngandu, Tiia, Barbera, Mariagnese, Kivipelto, Miia, Mangiasche, Francesca, Andrieu, Sandrine, Coley, Nicola, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, Brayne, Carol, Solomon, Alina, Laatikainen, Tiina, Strandberg, Timo, Tuomilehto, Jaakko, Antikainen, Riitta, Lindström, Jaana, Lehtisalo, Jenni, Havulinna, Satu, Rauramaa, Rainer, Hänninen, Tuomo, Bäckman, Lars, Stigsdotter-Neely, Anna, Jula, Antti, Peltonen, Markku, Levälahti, Esko, Grönholm, Marko, Hemiö, Katri, Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Cerda, Sandrine, Marie-Noëlle-Cuffi, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Yung Tong, Michael Li, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristelle, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, and Olivier-Abbal, Pascale

Published
2019
Full Text
View/download PDF

20. Design and Development of a Mobile Health (mHealth) Platform for Dementia Prevention in the Prevention of Dementia by Mobile Phone Applications (PRODEMOS) Project

Author

Hafdi, Melanie, primary, Eggink, Esmé, additional, Hoevenaar-Blom, Marieke P., additional, Witvliet, M. Patrick, additional, Andrieu, Sandrine, additional, Barnes, Linda, additional, Brayne, Carol, additional, Brooks, Rachael, additional, Coley, Nicola, additional, Georges, Jean, additional, van der Groep, Abraham, additional, van Marwijk, Harm, additional, van der Meijden, Mark, additional, Song, Libin, additional, Song, Manshu, additional, Wang, Youxin, additional, Wang, Wenzhi, additional, Wang, Wei, additional, Wimo, Anders, additional, Ye, Xiaoyan, additional, Moll van Charante, Eric P., additional, and Richard, Edo, additional

Published
2021
Full Text
View/download PDF

21. Engagement with a preventive eHealth intervention in older adults (the HATICE trial): Predictive factors and associations with dementia and cardiovascular risk

Author

Coley, Nicola, primary, Andre, Laurine, additional, Hoevenaar‐Blom, Marieke P, additional, Ngandu, Tiia, additional, Beishuizen, Cathrien, additional, Barbera, Mariagnese, additional, van Wanrooij, Lennard, additional, Kivipelto, Miia, additional, Soininen, Hilkka, additional, Brayne, Carol, additional, van Charante, Eric P Moll, additional, Richard, Edo, additional, and Andrieu, Sandrine, additional

Published
2021
Full Text
View/download PDF

28. Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial

Author

Eggink, Esmé, primary, Hafdi, Melanie, additional, Hoevenaar-Blom, Marieke P, additional, Song, Manshu, additional, Andrieu, Sandrine, additional, Barnes, Linda E, additional, Birck, Cindy, additional, Brooks, Rachael L, additional, Coley, Nicola, additional, Ford, Elizabeth, additional, Georges, Jean, additional, van der Groep, Abraham, additional, van Gool, Willem A, additional, Handels, Ron, additional, Hou, Haifeng, additional, Li, Dong, additional, Liu, Hongmei, additional, Lyu, Jihui, additional, van Marwijk, Harm, additional, van der Meijden, Mark, additional, Niu, Yixuan, additional, Sadhwani, Shanu, additional, Wang, Wenzhi, additional, Wang, Youxin, additional, Wimo, Anders, additional, Ye, Xiaoyan, additional, Yu, Yueyi, additional, Zeng, Qiang, additional, Zhang, Wei, additional, Wang, Wei, additional, Brayne, Carol, additional, Moll van Charante, Eric P, additional, and Richard, Edo, additional

Published
2021
Full Text
View/download PDF

29. Experiences of dementia and attitude towards prevention: A qualitative study among older adults participating in a prevention trial

Author

Rosenberg, Anna, Coley, Nicola, Soulier, Alexandra, Kulmala, Jenni, Soininen, Hilkka, Andrieu, Sandrine, Kivipelto, Miia, Barbera, Mariagnese, Sindi, Shireen, Solomon, Alina, Richard, Edo, van Middelaar, Tessa, Hartmann, Tobias, Brayne, Carol, van Gool, Pim, Moll van Charante, Eric, Beishuizen, Cathrien, Jongstra, Susan, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Ngandu, Tiia, Mangialasche, Francesca, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, General practice, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Aging & Later Life, Graduate School, ANS - Neurodegeneration, Neurology, APH - Digital Health, and ACS - Diabetes & metabolism

Subjects
Randomised controlled trial, Cognitive impairment, Healthy ageing, Older adults, Prevention, Qualitative research, Family history, Risk reduction, Dementia, Alzheimer's disease
Abstract

Background: A better insight into older adults' understanding of and attitude towards cognitive disorders and their prevention, as well as expectations and reasons for participation in prevention trials, would help design, conduct, and implement effective preventive interventions. This qualitative study aimed at exploring the knowledge and perceptions of cognitive disorders and their prevention among participants in a prevention trial. Methods: Semi-structured interviews were conducted among the participants of a multinational randomised controlled trial testing the efficacy of a lifestyle-based eHealth intervention in preventing cardiovascular disease or cognitive decline in community dwellers aged 65+. Participants were probed on their reasons for participation in the trial and their views on general health, cardiovascular disease, ageing, and prevention. The subset of data focusing on cognitive disorders (15 interviewees; all in Finland) was considered for this study. Data were analysed using content analysis. Results: Participants' knowledge of the cause and risk factors of cognitive disorders and prevention was limited and superficial, and a need for up-to-date, reliable, and practical information and advice was expressed. Cognitive disorders evoked fear and concern, and feelings of hopelessness and misery were frequently expressed, indicating a stigma. Strong heredity of cognitive disorders was a commonly held belief, and opinions on the possibility of prevention were doubtful, particularly in relation to primary prevention. Family history and/or indirect experiences of cognitive disorders was a recurrent theme and it showed to be linked to both the knowledge of and feelings associated with cognitive disorders, as well as attitude towards prevention. Indirect experiences were linked to increased awareness and knowledge, but also uncertainty about risk factors and possibility of prevention. Distinct fear and concerns, particularly over one's own cognition/risk, and high motivation towards engaging in prevention and participating in a prevention trial were also identified in connection to this theme. Conclusions: Family history and/or indirect experiences of cognitive disorders were linked to sensitivity and receptiveness to brain health and prevention potential. Our findings may be helpful in addressing older adults' expectations in future prevention trials to improve recruitment, maximise adherence, and facilitate the successful implementation of interventions.

Published
2020

30. Experiences of dementia and attitude towards prevention : a qualitative study among older adults participating in a prevention trial

Author

Coley, Nicola, Soulier, Alexandra, Kulmala, Jenni, Andrieu, Sandrine, Kivipelto, Miia, Sindi, Shireen, Solomon, Alina, Soininen, Hilkka, Rosenberg, Anna, Richard, Edo, Hartmann, Tobias, Gool, Pim van, Charante, Eric Moll van, Beishuizen, Cathrien, Jongstra, Susan, Middelaar, Tessa van, Wanrooij, Lennard van, Hoevenaar-Blom, Marieke, Ngandu, Tiia, Barbera, Mariagnese, Mangialasche, Francesca, Guillemont, Juliette, Meiller, Yannick, Groep, Bram van de, Brayne, Carol, Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), and Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Abstract Background A better insight into older adults’ understanding of and attitude towards cognitive disorders and their prevention, as well as expectations and reasons for participation in prevention trials, would help design, conduct, and implement effective preventive interventions. This qualitative study aimed at exploring the knowledge and perceptions of cognitive disorders and their prevention among participants in a prevention trial. Methods Semi-structured interviews were conducted among the participants of a multinational randomised controlled trial testing the efficacy of a lifestyle-based eHealth intervention in preventing cardiovascular disease or cognitive decline in community dwellers aged 65+. Participants were probed on their reasons for participation in the trial and their views on general health, cardiovascular disease, ageing, and prevention. The subset of data focusing on cognitive disorders (15 interviewees; all in Finland) was considered for this study. Data were analysed using content analysis. Results Participants’ knowledge of the cause and risk factors of cognitive disorders and prevention was limited and superficial, and a need for up-to-date, reliable, and practical information and advice was expressed. Cognitive disorders evoked fear and concern, and feelings of hopelessness and misery were frequently expressed, indicating a stigma. Strong heredity of cognitive disorders was a commonly held belief, and opinions on the possibility of prevention were doubtful, particularly in relation to primary prevention. Family history and/or indirect experiences of cognitive disorders was a recurrent theme and it showed to be linked to both the knowledge of and feelings associated with cognitive disorders, as well as attitude towards prevention. Indirect experiences were linked to increased awareness and knowledge, but also uncertainty about risk factors and possibility of prevention. Distinct fear and concerns, particularly over one’s own cognition/risk, and high motivation towards engaging in prevention and participating in a prevention trial were also identified in connection to this theme. Conclusions Family history and/or indirect experiences of cognitive disorders were linked to sensitivity and receptiveness to brain health and prevention potential. Our findings may be helpful in addressing older adults’ expectations in future prevention trials to improve recruitment, maximise adherence, and facilitate the successful implementation of interventions.

Published
2020

32. Prevention of dementia using mobile phone applications (PRODEMOS): A randomized controlled trial in progress

Author

Eggink, Esmé, primary, van Charante, Eric P Moll, additional, Hoevenaar‐Blom, Marieke P, additional, Andrieu, Sandrine, additional, Hafdi, Melanie, additional, Coley, Nicola, additional, Sadhwani, Shan, additional, Wimo, Anders, additional, Barnes, Linda, additional, Handels, Ron, additional, Kivipelto, Miia, additional, Song, Manshu, additional, Georges, Jean, additional, van Der Groep, Bram, additional, van der Meijden, Mark, additional, Wang, Youxin, additional, Wang, Wei, additional, van Gool, Willem A, additional, van Marwijk, Harm, additional, Brayne, Carol, additional, and Richard, Edo, additional

Published
2020
Full Text
View/download PDF

33. Pooling individual participant data from randomized controlled trials: Exploring potential loss of information

Author

van Wanrooij, Lennard L., primary, Hoevenaar-Blom, Marieke P., additional, Coley, Nicola, additional, Ngandu, Tiia, additional, Meiller, Yannick, additional, Guillemont, Juliette, additional, Rosenberg, Anna, additional, Beishuizen, Cathrien R. L., additional, Moll van Charante, Eric P., additional, Soininen, Hilkka, additional, Brayne, Carol, additional, Andrieu, Sandrine, additional, Kivipelto, Miia, additional, and Richard, Edo, additional

Published
2020
Full Text
View/download PDF

35. Additional file 1: of Modifiable dementia risk score to study heterogeneity in treatment effect of a dementia prevention trial: a post hoc analysis in the preDIVA trial using the LIBRA index

Author

Middelaar, Tessa Van, Hoevenaar-Blom, Marieke, Gool, Willem Van, Charante, Eric Moll Van, Jan-Willem Van Dalen, Deckers, Kay, Kรถhler, Sebastian, and Richard, Edo

Abstract

Figure S1. Flow diagram. Table S1. Baseline characteristics per randomisation group and LIBRA group. Table S2. Secondary analyses. Table S3. Competing risk analysis. Table S4. Subgroup analyses on age, hypertension grade, antihypertensive medication, history of cardiovascular disease and diabetes. Table S5. Treatment effect on vascular risk factors in LIBRA groups. Table S6. Baseline characteristics of participants included in and excluded from cognitive analyses. Table S7. Treatment effect on cognition in LIBRA groups (DOCX 533 kb)

Published
2018
Full Text
View/download PDF

38. Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison

Author

Coley, Nicola, primary, Rosenberg, Anna, additional, van Middelaar, Tessa, additional, Soulier, Alexandra, additional, Barbera, Mariagnese, additional, Guillemont, Juliette, additional, Steensma, Jaap, additional, Igier, Valérie, additional, Eskelinen, Marjo, additional, Soininen, Hilkka, additional, Moll van Charante, Eric, additional, Richard, Edo, additional, Kivipelto, Miia, additional, Andrieu, Sandrine, additional, Sindi, Shireen, additional, Solomon, Alina, additional, Coley, Nicola, additional, Hartmann, Tobias, additional, Brayne, Carol, additional, van Gool, Pim, additional, Beishuizen, Cathrien, additional, Jongstra, Susan, additional, van Wanrooij, Lennard, additional, Hoevenaar-Blom, Marieke, additional, Ngandu, Tiia, additional, Mangiasche, Francesca, additional, Meiller, Yannick, additional, van de Groep, Bram, additional, and Braynefor, Carol, additional

Published
2019
Full Text
View/download PDF

39. A cardiovascular risk prediction model for older people: Development and validation in a primary care population.

Author

Bussel, Emma F., Richard, Edo, Busschers, Wim B., Steyerberg, Ewout W., Gool, Willem A., Moll van Charante, Eric P., Hoevenaar‐Blom, Marieke P., van Bussel, Emma F, van Gool, Willem A, and Hoevenaar-Blom, Marieke P

Abstract

Cardiovascular risk prediction is mainly based on traditional risk factors that have been validated in middle-aged populations. However, associations between these risk factors and cardiovascular disease (CVD) attenuate with increasing age. Therefore, for older people the authors developed and internally validated risk prediction models for fatal and non-fatal CVD, (re)evaluated the predictive value of traditional and new factors, and assessed the impact of competing risks of non-cardiovascular death. Post hoc analyses of 1811 persons aged 70-78 year and free from CVD at baseline from the preDIVA study (Prevention of Dementia by Intensive Vascular care, 2006-2015), a primary care-based trial that included persons free from dementia and conditions likely to hinder successful long-term follow-up, were performed. In 2017-2018, Cox-regression analyses were performed for a model including seven traditional risk factors only, and a model to assess incremental predictive ability of the traditional and eleven new factors. Analyses were repeated accounting for competing risk of death, using Fine-Gray models. During an average of 6.2 years of follow-up, 277 CVD events occurred. Age, sex, smoking, and type 2 diabetes mellitus were traditional predictors for CVD, whereas total cholesterol, HDL-cholesterol, and systolic blood pressure (SBP) were not. Of the eleven new factors, polypharmacy and apathy symptoms were predictors. Discrimination was moderate (concordance statistic 0.65). Accounting for competing risks resulted in slightly smaller predicted absolute risks. In conclusion, we found, SBP, HDL, and total cholesterol no longer predict CVD in older adults, whereas polypharmacy and apathy symptoms are two new relevant predictors. Building on the selected risk factors in this study may improve CVD prediction in older adults and facilitate targeting preventive interventions to those at high risk. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

40. Dementia risk scores as surrogate outcomes for lifestyle‐based multidomain prevention trials—rationale, preliminary evidence and challenges.

Author

Coley, Nicola, Hoevenaar‐Blom, Marieke P., Dalen, Jan‐Willem, Moll van Charante, Eric P., Kivipelto, Miia, Soininen, Hilkka, Andrieu, Sandrine, and Richard, Edo

Abstract

Introduction: Although not designed as such, dementia risk scores might be useful surrogate outcomes for dementia prevention trials. Their suitability may be improved by using continuous scoring systems, taking into account all changes in risk factors, not only those crossing cut‐off values. Methods: In three large multidomain dementia prevention trials with 1.5 to 2 years of follow‐up (Multidomain Alzheimer Preventive Trial, Prevention of Dementia by Intensive Vascular Care and Healthy Ageing Through Internet Counselling in the Elderly) we assessed (1) responsiveness (sensitivity to change) and (2) actual and simulated intervention effects of the original and crude/weighted z‐score versions of the cardiovascular risk factors, aging and incidence of dementia, and Lifestyle for Brain Health scores. Results: All versions of the risk scores were generally responsive, and able to detect small though statistically significant between‐group differences after multidomain interventions. Simulated intervention effects were well detected in z‐score versions as well as in the original scores. Discussion: Dementia risk scores and their z‐score versions show potential as surrogate outcomes. How changes in risk scores affect dementia remains to be determined. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

42. Improving data sharing in research with context-free encoded missing data

Author

Hoevenaar-Blom, Marieke P., primary, Guillemont, Juliette, additional, Ngandu, Tiia, additional, Beishuizen, Cathrien R. L., additional, Coley, Nicola, additional, Moll van Charante, Eric P., additional, Andrieu, Sandrine, additional, Kivipelto, Miia, additional, Soininen, Hilkka, additional, Brayne, Carol, additional, Meiller, Yannick, additional, and Richard, Edo, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results