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1. Epidemiology of heart failure

Author

Groenewegen, Amy, additional, Milinković, Ivan, additional, Hoes, Arno W, additional, Mosterd, Arend, additional, and Rutten, Frans H, additional

Published
2023
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2. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-randomised, controlled trial

Author

Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, and de Boer, Rudolf A

Published
2024
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3. Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Author

Joosten, Linda P.T., van Doorn, Sander, van de Ven, Peter M., Köhlen, Bart T.G., Nierman, Melchior C., Koek, Huiberdina L., Hemels, Martin E.W., Huisman, Menno V., Kruip, Marieke, Faber, Laura M., Wiersma, Nynke M., Buding, Wim F., Fijnheer, Rob, Adriaansen, Henk J., Roes, Kit C., Hoes, Arno W., Rutten, Frans H., and Geersing, Geert-Jan

Published
2024
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8. Discovery of novel heart rate-associated loci using the Exome Chip

Author

van den Berg, Marten E, Warren, Helen R, Cabrera, Claudia P, Verweij, Niek, Mifsud, Borbala, Haessler, Jeffrey, Bihlmeyer, Nathan A, Fu, Yi-Ping, Weiss, Stefan, Lin, Henry J, Grarup, Niels, Li-Gao, Ruifang, Pistis, Giorgio, Shah, Nabi, Brody, Jennifer A, Müller-Nurasyid, Martina, Lin, Honghuang, Mei, Hao, Smith, Albert V, Lyytikäinen, Leo-Pekka, Hall, Leanne M, van Setten, Jessica, Trompet, Stella, Prins, Bram P, Isaacs, Aaron, Radmanesh, Farid, Marten, Jonathan, Entwistle, Aiman, Kors, Jan A, Silva, Claudia T, Alonso, Alvaro, Bis, Joshua C, de Boer, Rudolf, de Haan, Hugoline G, de Mutsert, Renée, Dedoussis, George, Dominiczak, Anna F, Doney, Alex SF, Ellinor, Patrick T, Eppinga, Ruben N, Felix, Stephan B, Guo, Xiuqing, Hagemeijer, Yanick, Hansen, Torben, Harris, Tamara B, Heckbert, Susan R, Huang, Paul L, Hwang, Shih-Jen, Kähönen, Mika, Kanters, Jørgen K, Kolcic, Ivana, Launer, Lenore J, Li, Man, Yao, Jie, Linneberg, Allan, Liu, Simin, Macfarlane, Peter W, Mangino, Massimo, Morris, Andrew D, Mulas, Antonella, Murray, Alison D, Nelson, Christopher P, Orrú, Marco, Padmanabhan, Sandosh, Peters, Annette, Porteous, David J, Poulter, Neil, Psaty, Bruce M, Qi, Lihong, Raitakari, Olli T, Rivadeneira, Fernando, Roselli, Carolina, Rudan, Igor, Sattar, Naveed, Sever, Peter, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Timothy D, Stanton, Alice V, Stirrups, Kathleen E, Taylor, Kent D, Tobin, Martin D, Uitterlinden, André, Vaartjes, Ilonca, Hoes, Arno W, van der Meer, Peter, Völker, Uwe, Waldenberger, Melanie, Xie, Zhijun, Zoledziewska, Magdalena, Tinker, Andrew, Polasek, Ozren, Rosand, Jonathan, Jamshidi, Yalda, van Duijn, Cornelia M, Zeggini, Eleftheria, Jukema, J Wouter, Asselbergs, Folkert W, Samani, Nilesh J, and Lehtimäki, Terho

Subjects
Biological Sciences, Genetics, Human Genome, Biotechnology, Heart Disease, Prevention, Cardiovascular, Stem Cell Research, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adult, Alleles, Exome, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Heart Rate, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Risk Factors, White People, Medical and Health Sciences, Genetics & Heredity
Abstract

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip. Twenty-four variants were selected for follow-up in an independent dataset (UK Biobank, N = 134 251). Conditional and gene-based testing was undertaken, and variants were investigated with bioinformatics methods.We discovered five novel heart rate loci, and one new independent low-frequency non-synonymous variant in an established heart rate locus (KIAA1755). Lead variants in four of the novel loci are non-synonymous variants in the genes C10orf71, DALDR3, TESK2 and SEC31B. The variant at SEC31B is significantly associated with SEC31B expression in heart and tibial nerve tissue. Further candidate genes were detected from long-range regulatory chromatin interactions in heart tissue (SCD, SLF2 and MAPK8). We observed significant enrichment in DNase I hypersensitive sites in fetal heart and lung. Moreover, enrichment was seen for the first time in human neuronal progenitor cells (derived from embryonic stem cells) and fetal muscle samples by including our novel variants.Our findings advance the knowledge of the genetic architecture of heart rate, and indicate new candidate genes for follow-up functional studies.

Published
2017

10. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD):a multicentre, pragmatic, cluster-randomised, controlled trial

Author

Groenewegen, Amy, Zwartkruis, Victor W., Rienstra, Michiel, Zuithoff, Nicolaas P.A., Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J., van der Schouw, Yvonne T., Hoes, Arno W., Rutten, Frans H., de Boer, Rudolf A., Groenewegen, Amy, Zwartkruis, Victor W., Rienstra, Michiel, Zuithoff, Nicolaas P.A., Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J., van der Schouw, Yvonne T., Hoes, Arno W., Rutten, Frans H., and de Boer, Rudolf A.

Abstract

Background: Progressive cardiovascular diseases (eg, heart failure, atrial fibrillation, and coronary artery disease) are often diagnosed late in high-risk individuals with common comorbidities that might mimic or mask symptoms, such as chronic obstructive pulmonary disease (COPD) and type 2 diabetes. We aimed to assess whether a proactive diagnostic strategy consisting of a symptom and risk factor questionnaire and low-cost and accessible tests could increase diagnosis of progressive cardiovascular diseases in patients with COPD or type 2 diabetes in primary care. Methods:In this multicentre, pragmatic, cluster-randomised, controlled trial (RED-CVD), 25 primary care practices in the Netherlands were randomly assigned to usual care or a proactive diagnostic strategy conducted during routine consultations and consisting of a validated symptom questionnaire, followed by physical examination, N-terminal-pro-B-type natriuretic peptide measurement, and electrocardiography. We included adults (≥18 years) with type 2 diabetes, COPD, or both, who participated in a disease management programme. Patients with an established triple diagnosis of heart failure, atrial fibrillation, and coronary artery disease were excluded. In the case of abnormal findings, further work-up or treatment was done at the discretion of the general practitioner. The primary endpoint was the number of newly diagnosed cases of heart failure, atrial fibrillation, and coronary artery disease, adjudicated by an expert clinical outcome committee using international guidelines, at 1-year follow-up, in the intention-to-treat population. Findings: Between Jan 31, 2019, and Oct 7, 2021, we randomly assigned 25 primary care centres: 11 to usual care and 14 to the intervention. We included patients between June 21, 2019, and Jan 31, 2022. Following exclusion of ineligible patients and those who did not give informed consent, 1216 participants were includ

Published
2024

11. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-randomised, controlled trial

Author

HAG Hart- Vaatziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Cardiovasculaire Epi Team 1, Directie Raad van Bestuur, Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, de Boer, Rudolf A, HAG Hart- Vaatziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Cardiovasculaire Epi Team 1, Directie Raad van Bestuur, Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, and de Boer, Rudolf A

Published
2024

12. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Author

HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, Geersing, Geert-Jan, HAG Trombose, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTM & Statistical consultation, Cancer, MS Geriatrie, Circulatory Health, Directie Raad van Bestuur, HAG Hart- Vaatziekten, Joosten, Linda P T, van Doorn, Sander, van de Ven, Peter M, Köhlen, Bart T G, Nierman, Melchior C, Koek, Huiberdina L, Hemels, Martin E W, Huisman, Menno V, Kruip, Marieke, Faber, Laura M, Wiersma, Nynke M, Buding, Wim F, Fijnheer, Rob, Adriaansen, Henk J, Roes, Kit C, Hoes, Arno W, Rutten, Frans H, and Geersing, Geert-Jan

Published
2024

15. International Consortium for Health Outcomes Measurement (ICHOM): Standardized Patient-Centered Outcomes Measurement Set for Heart Failure Patients

Author

Burns, Daniel J.P., Arora, Jason, Okunade, Oluwakemi, Beltrame, John F., Bernardez-Pereira, Sabrina, Crespo-Leiro, Marisa G., Filippatos, Gerasimos S., Hardman, Suzanna, Hoes, Arno W., Hutchison, Stephen, Jessup, Mariell, Kinsella, Tina, Knapton, Michael, Lam, Carolyn S.P., Masoudi, Frederick A., McIntyre, Hugh, Mindham, Richard, Morgan, Louise, Otterspoor, Luuk, Parker, Victoria, Persson, Hans E., Pinnock, Claude, Reid, Christopher M., Riley, Jillian, Stevenson, Lynne W., and McDonagh, Theresa A.

Published
2020
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21. Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial

Author

Joosten, Linda P.T., primary, van Doorn, Sander, additional, van de Ven, Peter M., additional, Köhlen, Bart T.G., additional, Nierman, Melchior C., additional, Koek, Huiberdina L., additional, Hemels, Martin E.W., additional, Huisman, Menno V., additional, Kruip, Marieke, additional, Faber, Laura M., additional, Wiersma, Nynke M., additional, Buding, Wim F., additional, Fijnheer, Rob, additional, Adriaansen, Henk J., additional, Roes, Kit C., additional, Hoes, Arno W., additional, Rutten, Frans H., additional, and Geersing, Geert-Jan, additional

Published
2023
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22. Guía ESC 2021 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureGrupo de Trabajo de la Sociedad Europea de Cardiología (ESC) de diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónicaDesarrollada con la colaboración especial de la Heart Failure Association (HFA) de la ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Coats, Andrew J.S., Crespo-Leiro, María G., Farmakis, Dimitrios, Gilard, Martine, Heyman, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Published
2022
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27. Clinical consequences of off-label reduced dosing of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis

Author

Joosten, Linda P T, primary, van Maanen, Rosanne, additional, van den Dries, Carline J, additional, Rutten, Frans H, additional, Hoes, Arno W, additional, Granger, Christopher B, additional, Hemels, Martin E W, additional, Geersing, Geert-Jan, additional, and van Doorn, Sander, additional

Published
2023
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33. Safety of off‐label dose reduction of non‐vitamin K antagonist oral anticoagulants in patients with atrial fibrillation

Author

van den Dries, Carline J., Pajouheshnia, Romin, van den Ham, Hendrika A., Souverein, Patrick, Moons, Karel G.M., Hoes, Arno W., Geersing, Geert Jan, van Doorn, Sander, Afd Pharmacoepi & Clinical Pharmacology, Sub Biomol.Mass Spectrometry & Proteom., Pharmacoepidemiology and Clinical Pharmacology, and Biomolecular Mass Spectrometry and Proteomics

Subjects
Pharmacology, Anticoagulation, non-vitamin K antagonist oral anticoagulants, Pharmacology (medical), Off-label dose reduction, Atrial fibrillation
Abstract

Aim: To investigate the effects of off-label non-vitamin K oral anticoagulant (NOAC) dose reduction compared with on-label standard dosing in atrial fibrillation (AF) patients in routine care. Methods: Population-based cohort study using data from the United Kingdom Clinical Practice Research Datalink, comparing adults with non-valvular AF receiving an off-label reduced NOAC dose to patients receiving an on-label standard dose. Outcomes were ischaemic stroke, major/non-major bleeding and mortality. Inverse probability of treatment weighting and inverse probability of censoring weighting on the propensity score were applied to adjust for confounding and informative censoring. Results: Off-label dose reduction occurred in 2466 patients (8.0%), compared with 18 108 (58.5%) on-label standard-dose users. Median age was 80 years (interquartile range [IQR] 73.0-86.0) versus 72 years (IQR 66-78), respectively. Incidence rates were higher in the off-label dose reduction group compared to the on-label standard dose group, for ischaemic stroke (0.94 vs 0.70 per 100 person years), major bleeding (1.48 vs 0.83), non-major bleeding (6.78 vs 6.16) and mortality (10.12 vs 3.72). Adjusted analyses resulted in a hazard ratio of 0.95 (95% confidence interval [CI] 0.57-1.60) for ischaemic stroke, 0.88 (95% CI 0.57-1.35) for major bleeding, 0.81 (95% CI 0.67-0.98) for non-major bleeding and 1.34 (95% CI 1.12-1.61) for mortality. Conclusion: In this large population-based study, the hazards for ischaemic stroke and major bleeding were low, and similar in AF patients receiving an off-label reduced NOAC dose compared with on-label standard dose users, while non-major bleeding risk appeared to be lower and mortality risk higher. Caution towards prescribing an off-label reduced NOAC dose is therefore required.

Published
2022

34. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo‐Leiro, Maria Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, and Lam, Carolyn S.P.

Subjects
HEART failure, TASK forces, CARDIOLOGY, DIAGNOSIS, ELECTRONIC journals, AFRIKANERS
Abstract

Document Reviewers: Rudolf A. de Boer (CPG Review Co‐ordinator) (Netherlands), P. Christian Schulze (CPG Review Co‐ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio Buccheri (Sweden), Elisabetta Cerbai (Italy), Erwan Donal (France), Frank Edelmann (Germany), Gloria Färber (Germany), Bettina Heidecker (Germany), Borja Ibanez (Spain), Stefan James (Sweden), Lars Køber (Denmark), Konstantinos C. Koskinas (Switzerland), Josep Masip (Spain), John William McEvoy (Ireland), Robert Mentz (United States of America), Borislava Mihaylova (United Kingdom), Jacob Eifer Møller (Denmark), Wilfried Mullens (Belgium), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Agnes A. Pasquet (Belgium), Piotr Ponikowski (Poland), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Bianca Rocca (Italy), Xavier Rossello (Spain), Leyla Elif Sade (United States of America/Türkiye), Hannah Schaubroeck (Belgium), Elena Tessitore (Switzerland), Mariya Tokmakova (Bulgaria), Peter van der Meer (Netherlands), Isabelle C. Van Gelder (Netherlands), Mattias Van Heetvelde (Belgium), Christiaan Vrints (Belgium), Matthias Wilhelm (Switzerland), Adam Witkowski (Poland), and Katja Zeppenfeld (Netherlands) All experts involved in the development of this Focused Update have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the Focused Update. The report is also available on the ESC website www.escardio.org/guidelines See the European Heart Journal online for supplementary documents that include evidence tables. [ABSTRACT FROM AUTHOR]

Published
2024
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40. What Are Effective Program Characteristics of Self-Management Interventions in Patients With Heart Failure? An Individual Patient Data Meta-analysis

Author

Jonkman, Nini H., Westland, Heleen, Groenwold, Rolf H.H., Ågren, Susanna, Anguita, Manuel, Blue, Lynda, Bruggink-André de la Porte, Pieta W.F., DeWalt, Darren A., Hebert, Paul L., Heisler, Michele, Jaarsma, Tiny, Kempen, Gertrudis I.J.M., Leventhal, Marcia E., Lok, Dirk J.A., Mårtensson, Jan, Muñiz, Javier, Otsu, Haruka, Peters-Klimm, Frank, Rich, Michael W., Riegel, Barbara, Strömberg, Anna, Tsuyuki, Ross T., Trappenburg, Jaap C.A., Schuurmans, Marieke J., and Hoes, Arno W.

Published
2016
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44. Sex Differences in the Generalizability of Randomized Clinical Trials in Heart Failure with Reduced Ejection Fraction

Author

Schroeder, Megan, primary, Lim, Yvonne Mei Fong, additional, Savarese, Gianluigi, additional, Suzart‐Woischnik, Kiliana, additional, Baudier, Claire, additional, Dyszynski, Tomasz, additional, Vaartjes, Ilonca, additional, Eijkemans, Marinus JC, additional, Uijl, Alicia, additional, Herrera, Ronald, additional, Vradi, Eleni, additional, Brugts, Jasper J., additional, Rocca, Hans‐Peter Brunner‐La, additional, Blanc‐Guillemaud, Vanessa, additional, Waechter, Sandra, additional, Couvelard, Fabrice, additional, Tyl, Benoit, additional, Fatoba, Samuel, additional, Hoes, Arno W, additional, Lund, Lars H, additional, Gerlinger, Christoph, additional, Asselbergs, Folkert W, additional, Grobbee, Diederick E, additional, Cronin, Maureen, additional, and Koudstaal, Stefan, additional

Published
2023
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45. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haram, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo-Leiro, María Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, Skibelund, Anne Kathrine, McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haram, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo-Leiro, María Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Published
2023

46. Managing the Increasing Burden of Atrial Fibrillation through Integrated Care in Primary Care: A Cost-Effectiveness Analysis

Author

Circulatory Health, HAG Trombose, HEE, Child Health, JC onderzoeksprogramma Methodologie, Directie Raad van Bestuur, Epi Methoden, Cancer, van den Dries, Carline J, van der Meulen, Miriam P, Frederix, Geert W J, Hoes, Arno W, Moons, Karel G M, Geersing, Geert-Jan, Circulatory Health, HAG Trombose, HEE, Child Health, JC onderzoeksprogramma Methodologie, Directie Raad van Bestuur, Epi Methoden, Cancer, van den Dries, Carline J, van der Meulen, Miriam P, Frederix, Geert W J, Hoes, Arno W, Moons, Karel G M, and Geersing, Geert-Jan

Published
2023

47. Clinical consequences of off-label reduced dosing of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis

Author

HAG Trombose, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Directie Raad van Bestuur, Joosten, Linda P T, van Maanen, Rosanne, van den Dries, Carline J, Rutten, Frans H, Hoes, Arno W, Granger, Christopher B, Hemels, Martin E W, Geersing, Geert-Jan, van Doorn, Sander, HAG Trombose, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Directie Raad van Bestuur, Joosten, Linda P T, van Maanen, Rosanne, van den Dries, Carline J, Rutten, Frans H, Hoes, Arno W, Granger, Christopher B, Hemels, Martin E W, Geersing, Geert-Jan, and van Doorn, Sander

Published
2023

48. Safety of off-label dose reduction of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation

Author

Circulatory Health, HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Directie Raad van Bestuur, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van den Dries, Carline J, Pajouheshnia, Romin, van den Ham, Hendrika A, Souverein, Patrick, Moons, Karel G M, Hoes, Arno W, Geersing, Geert-Jan, van Doorn, Sander, Circulatory Health, HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Directie Raad van Bestuur, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van den Dries, Carline J, Pajouheshnia, Romin, van den Ham, Hendrika A, Souverein, Patrick, Moons, Karel G M, Hoes, Arno W, Geersing, Geert-Jan, and van Doorn, Sander

Published
2023

49. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias: The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author

Catapano, Alberico L., Graham, Ian, De Backer, Guy, Wiklund, Olov, Chapman, M. John, Drexel, Heinz, Hoes, Arno W., Jennings, Catriona S., Landmesser, Ulf, Pedersen, Terje R., Reiner, Željko, Riccardi, Gabriele, Taskinen, Marja-Riita, Tokgozoglu, Lale, Verschuren, W.M. Monique, Vlachopoulos, Charalambos, Wood, David A., and Zamorano, Jose Luis

Published
2016
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