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10 results on '"Hoelzer, Bodo"'

1. Impact of low eGFR on the immune response against COVID-19

Author

Blazquez-Navarro, Arturo, Mittmann, Lisa, Thieme, Constantin Joachim, Anft, Moritz, Paniskaki, Krystallenia, Doevelaar, Adrian, Seibert, Felix Sebastian, Hoelzer, Bodo, Konik, Margarete Justine, Berger, Marc Moritz, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Meister, Toni Luise, Pfaender, Stephanie, Steinmann, Eike, Dolff, Sebastian, Dittmer, Ulf, Witzke, Oliver, Stervbo, Ulrik, Roch, Toralf, Or-Guil, Michal, Westhoff, Timm Henning, and Babel, Nina

Published
2023
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2. Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients

Author

Thieme, Constantin J., Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian, Seibert, Felix S., Hoelzer, Bodo, Konik, Margarethe Justine, Berger, Marc Moritz, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Meister, Toni L., Pfaender, Stephanie, Steinmann, Eike, Dolff, Sebastian, Dittmer, Ulf, Westhoff, Timm H., Witzke, Oliver, Stervbo, Ulrik, Roch, Toralf, and Babel, Nina

Published
2020
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3. The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression

Author

Thieme, Constantin J., Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian, Seibert, Felix S., Hoelzer, Bodo, Justine Konik, Margarethe, Meister, Toni L., Pfaender, Stephanie, Steinmann, Eike, Moritz Berger, Marc, Brenner, Thorsten, Kölsch, Uwe, Dolff, Sebastian, Roch, Toralf, Witzke, Oliver, Schenker, Peter, Viebahn, Richard, Stervbo, Ulrik, Westhoff, Timm H., and Babel, Nina

Published
2021
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4. Impact of low eGFR on the immune response against COVID-19

Author

Blazquez-Navarro, Arturo, primary, Mittmann, Lisa, additional, Thieme, Constantin Joachim, additional, Anft, Moritz, additional, Paniskaki, Krystallenia, additional, Doevelaar, Adrian, additional, Seibert, Felix Sebastian, additional, Hoelzer, Bodo, additional, Konik, Margarete Justine, additional, Berger, Marc Moritz, additional, Brenner, Thorsten, additional, Tempfer, Clemens, additional, Watzl, Carsten, additional, Meister, Toni Luise, additional, Pfaender, Stephanie, additional, Steinmann, Eike, additional, Dolff, Sebastian, additional, Dittmer, Ulf, additional, Witzke, Oliver, additional, Stervbo, Ulrik, additional, Roch, Toralf, additional, Or-Guil, Michal, additional, Westhoff, Timm Henning, additional, and Babel, Nina, additional

Published
2022
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6. COVID-19 progression is potentially driven by T cell immunopathogenesis

Author

Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian Atila Nicolas, Seibert, Felix, Hoelzer, Bodo, Skrzypczyk, Sarah, Kohut, Eva, Kurek, Julia, Zapka, Jan, Wehler, Patrizia, Kaliszczyk, Sviatlana, Bajda, Sharon, Thieme, Constantin, Roch, Toralf, Konik, Margarethe Justine, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Dolff, Sebastian, Dittmer, Ulf, Westhoff, Timm, Witzke, Oliver, Stervbo, Ulrik, and Babel, Nina

Abstract

Background: The role of cellular immunity in pathogenesis of COVID-19 is unclear and conflicting data points to insufficient or pathogenic immunity as drivers of COVID-19 progression. Here we aimed to delineate the phenotype and function of the immune system in patients with moderate, severe, and critical COVID-19. Methods: In this prospective study, we included 53 patients with moderate (n=21), severe (n=18), and critical (n=14) COVID-19 manifestations. Using multiparametric flow cytometry we compared quantitative, phenotypic, and functional characteristics of circulating immune cells, SARS-CoV-2 antigen-reactive T-cells, and humoral immunity. Results: Deep phenotypic profiling revealed a depletion of circulating bulk CD8+ T-cells, CD4+ and CD8+ T-cell subsets with activated memory/effector T-cells expressing CD57+, HLA-DR+, and the key activation and migration molecule CD11a++ in critical COVID-19. Importantly, survival from acute respiratory distress syndrome was accompanied by a recovery of the depleted CD11++ T-cell subsets including T-cells expressing CD28, CD57, HLA-DR activation/effector molecules. We further observed a stronger response of S-protein specific T-cells producing inflammatory cytokines in critical COVID-19 cases. This seemingly contradictory observation is in fact confirmation of the underlying immunopathogenesis in patients with critical COVID-19. Conclusion: Our findings suggest a CD11a-based immune signature as a possible prognostic marker for disease development. Our data further reveal that increased rather than decreased SARS-CoV-2 specific T cell immunity is associated with adverse outcome in COVID-19. Tissue migration of activated effectors T-cells may constitute a crucial cornerstone in the immunopathogenesis of SARS-CoV-2 associated tissue injury.

Published
2020
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7. Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient

Author

Babel, Nina, primary, Anft, Moritz, additional, Blazquez-Navarro, Arturo, additional, Doevelaar, Adrian A.N., additional, Seibert, Felix S., additional, Bauer, Frederic, additional, Rohn, Benjamin J., additional, Hoelzer, Bodo, additional, Thieme, Constantin J., additional, Roch, Toralf, additional, Meister, Toni L., additional, Pfaender, Stephanie, additional, Steinmann, Eike, additional, Dittmer, Ulf, additional, Schenker, Peter, additional, Amann, Kerstin, additional, Viebahn, Richard, additional, Stervbo, Ulrik, additional, and Westhoff, Timm H., additional

Published
2020
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8. The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity

Author

Thieme, Constantin J, primary, Anft, Moritz, additional, Paniskaki, Krystallenia, additional, Blazquez-Navarro, Arturo, additional, Doevelaar, Adrian, additional, Seibert, Felix S, additional, Hoelzer, Bodo, additional, Konik, Margarethe Justine, additional, Brenner, Thorsten, additional, Tempfer, Clemens, additional, Watzl, Carsten, additional, Dolff, Sebastian, additional, Dittmer, Ulf, additional, Westhoff, Timm H., additional, Witzke, Oliver, additional, Stervbo, Ulrik, additional, Roch, Toralf, additional, and Babel, Nina, additional

Published
2020
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9. A possible role of immunopathogenesis in COVID-19 progression

Author

Anft, Moritz, primary, Paniskaki, Krystallenia, additional, Blazquez-Navarro, Arturo, additional, Doevelaar, Adrian, additional, Seibert, Felix S., additional, Hoelzer, Bodo, additional, Skrzypczyk, Sarah, additional, Kohut, Eva, additional, Kurek, Julia, additional, Zapka, Jan, additional, Wehler, Patrizia, additional, Kaliszczyk, Sviatlana, additional, Bajda, Sharon, additional, Thieme, Constantin J., additional, Roch, Toralf, additional, Justine Konik, Margarethe, additional, Brenner, Thorsten, additional, Tempfer, Clemens, additional, Watzl, Carsten, additional, Dolff, Sebastian, additional, Dittmer, Ulf, additional, Westhoff, Timm H., additional, Witzke, Oliver, additional, Stervbo, Ulrik, additional, and Babel, Nina, additional

Published
2020
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10. SARS-CoV-2–reactive cellular and humoral immunity in hemodialysis population

Author

Anft, Moritz, Blazquez-Navarro, Arturo, Paniskaki, Krystallenia, Skrzypczyk, Sarah, Appel, Heiner, Pfab, Thiemo, Uhle, Andrea, Frahnert, Michael, Barenbrock, Michael, Büssemaker, Eckhart, Hörstrup, Jan, Doevelaar, Adrian, Seibert, Felix S., Hölzer, Bodo, Stervbo, Ulrik, Dolff, Sebastian, Witzke, Oliver, Babel, Nina, and Westhoff, Timm H.

Published
2021
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