1,036 results on '"Hoekstra, M"'
Search Results
2. Endocrinologie
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Moeniralam, H. S., Zeillemaker-Hoekstra, M., Wietasch, J. K. G., de Bruin, A.F.J., editor, van Dongen, H.P.A., editor, and van Fessem, J.M.K., editor
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- 2023
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3. Anorexia nervosa: practical implications for the anaesthetist
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van den Berg, J.P., Elgersma, H.J., and Zeillemaker-Hoekstra, M.
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- 2023
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4. The scope of lexical rules
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M. Moortgat, H. v. d. Hulst, T. Hoekstra, M. Moortgat, H. v. d. Hulst, T. Hoekstra
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- 2020
5. Design, analysis and verification of a volume-of-fluid model with interface-capturing scheme
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Klaij, C.M., Hoekstra, M., and Vaz, G.
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- 2018
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6. The impact of CYP2C19 genotype on phenoconversion by concomitant medication
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Jong, L.M. de, Boussallami, S., Sánchez-López, E., Giera, M., Tushuizen, M.E., Hoekstra, M., Hawinkels, L.J.A.C., Rissmann, R., Swen, J.J., and Manson, M.L.
- Abstract
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted. Drug-drug-interactions (DDIs) caused by concomitant medication can however cause mismatches between predicted and observed phenotypes (phenoconversion). Here we investigated the impact of CYP2C19 genotype on the outcome of CYP2C19-dependent DDIs in human liver microsomes. Methods: Liver samples from 40 patients were included, and genotyped for CYP2C19*2, *3 and *17 variants. S-mephenytoin metabolism in microsomal fractions was used as proxy for CYP2C19 activity, and concordance between genotype-predicted and observed CYP2C19 phenotype was examined. Individual microsomes were subsequently co-exposed to fluvoxamine, voriconazole, omeprazole or pantoprazole to simulate DDIs. Results: Maximal CYP2C19 activity (Vmax) in genotype-predicted intermediate metabolizers (IMs; *1/*2 or *2/*17), rapid metabolizers (RMs; *1/*17) and ultrarapid metabolizers (UMs; *17/*17) was not different from Vmax of predicted normal metabolizers (NMs; *1/*1). Conversely, CYP2C19*2/*2 genotyped-donors exhibited Vmax rates ∼9% of NMs, confirming the genotype-predicted poor metabolizer (PM) phenotype. Categorizing CYP2C19 activity, we found a 40% concordance between genetically-predicted CYP2C19 phenotypes and measured phenotypes, indicating substantial phenoconversion. Eight patients (20%) exhibited CYP2C19 IM/PM phenotypes that were not predicted by their CYP2C19 genotype, of which six could be linked to the presence of diabetes or liver disease. In subsequent DDI experiments, CYP2C19 activity was inhibited by omeprazole (-37% ± 8%), voriconazole (-59% ± 4%) and fluvoxamine (-85% ± 2%), but not by pantoprazole (-2 ± 4%). The strength of CYP2C19 inhibitors remained unaffected by CYP2C19 genotype, as similar percental declines in CYP2C19 activity and comparable metabolism-dependent inhibitory constants (Kinact/KI) of omeprazole were observed between CYP2C19 genotypes. However, the consequences of CYP2C19 inhibitor-mediated phenoconversion were different between CYP2C19 genotypes. In example, voriconazole converted 50% of *1/*1 donors to a IM/PM phenotype, but only 14% of *1/*17 donors. Fluvoxamine converted all donors to phenotypic IMs/PMs, but *1/*17 (14%) were less likely to become PMs than *1/*1 (50%) or *1/*2 and *2/*17 (57%). Conclusion: This study suggests that the differential outcome of CYP2C19-mediated DDIs between genotypes are primarily dictated by basal CYP2C19 activity, that may in part be predicted by CYP2C19 genotype but likely also depends on disease-related factors.
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- 2023
7. A Recurring Outbreak of Shigella sonnei among Traditionally Observant Jewish Children in New York City: The Risks of Daycare and Household Transmission
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Garrett, V., Bornschlegel, K., Lange, D., Reddy, V., Kornstein, L., Kornblum, J., Agasan, A., Hoekstra, M., Layton, M., and Sobel, J.
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- 2006
8. Pathogen-Specific Risk Factors and Protective Factors for Acute Diarrheal Illness in Children Aged 12-59 Months in São Paulo, Brazil
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Sobel, J., Gomes, T. A. T., Hoekstra, M., and Griffin, P. M.
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- 2004
9. A Multistate Outbreak of Salmonella enterica Serotype Newport Infection Linked to Mango Consumption: Impact of Water-Dip Disinfestation Technology
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Barrett, E., Gould, E., Reddy, V., Hoekstra, M., Sanders, J. P., Tauxe, R. V., and Slutsker, L.
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- 2003
10. Development of a standard set of PROs and generic PROMs for Dutch medical specialist care : Recommendations from the Outcome-Based Healthcare Program Working Group Generic PROMs.
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Oude Voshaar, Martijn, Terwee, C.B., Haverman, L., Kolk, B. van der, Harkes, M., Woerden, C.S. van, Breda, F. van, Breukink, S., Hoop, I. de, Vermeulen, H., Graaf, E. de, Hazelzet, J., Leiden, B. van, Stienen, J., Hoekstra, M., Bart, H., Bommel, H. van, Determann, D., Verburg, M., Wees, P.J. van der, Beurskens, A.J., Oude Voshaar, Martijn, Terwee, C.B., Haverman, L., Kolk, B. van der, Harkes, M., Woerden, C.S. van, Breda, F. van, Breukink, S., Hoop, I. de, Vermeulen, H., Graaf, E. de, Hazelzet, J., Leiden, B. van, Stienen, J., Hoekstra, M., Bart, H., Bommel, H. van, Determann, D., Verburg, M., Wees, P.J. van der, and Beurskens, A.J.
- Abstract
01 juni 2023, Contains fulltext : 292719.pdf (Publisher’s version ) (Open Access), PURPOSE: The added value of measuring patient-reported outcomes (PROs) for delivering patient-centered care and assessment of healthcare quality is increasingly evident. However, healthcare system wide data collection initiatives are hampered by the proliferation of patient-reported outcome measures (PROMs) and conflicting data collection standards. As part of a national initiative of the Dutch Ministry of Health, Welfare and Sport we developed a consensus-based standard set of generic PROs and PROMs to be implemented across Dutch medical specialist care. METHODS: A working group of mandated representatives of umbrella organizations involved in Dutch medical specialist care, together with PROM experts and patient organizations worked through a structured, consensus-driven co-creation process. This included literature reviews, online expert and working group meetings, and feedback from national patient- and umbrella organizations. The 'PROM-cycle' methodology was used to select feasible, valid, and reliable PROMs to obtain domain scores for each of the PROs included in the set. RESULTS: Eight PROs across different domains of health were ultimately endorsed: symptoms (pain & fatigue), functioning (physical, social/participation, mental [anxiety & depression]), and overarching (quality of life & perceived overall health). A limited number of generic PROMs was endorsed. PROMIS short forms were selected as the preferred instruments for all PROs. Several recommendations were formulated to facilitate healthcare system level adoption and implementation of the standard set. CONCLUSIONS: We developed a consensus-based standard set of Generic PROMs and a set of recommendations to facilitate healthcare system wide implementation across Dutch medical specialist care.
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- 2023
11. On code verification of RANS solvers
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Eça, L., Klaij, C.M., Vaz, G., Hoekstra, M., and Pereira, F.S.
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- 2016
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12. Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions
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Verwilligen, R.A.F., Mulder, L., Araujo, P.M., Carneiro, M., Bussmann, J., Hoekstra, M., and Eck, M. van
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Cell Biology ,Molecular Biology - Abstract
Background and aims: Scavenger receptor class B1 (SCARB1) -also known as the high-density lipoprotein (HDL) receptor -is a multi-ligand scavenger receptor that is primarily expressed in liver and steroidogenic organs. This receptor is known for its function in reverse cholesterol transport (RCT) in mammals and hence disruption leads to a massive increase in HDL cholesterol in these species. The extracellular domain of SCARB1 -which is important for cholesterol handling -is highly conserved across multiple vertebrates, except in zebrafish. Methods: To examine the functional conservation of SCARB1 among vertebrates, two stable scarb1 knockout zebrafish lines, scarb1 715delA (scarb1-1 nt) and scarb1 715_716insGG (scarb1 +2 nt), were created using CRISPR-Cas9 technology. Results: We demonstrate that, in zebrafish, SCARB1 deficiency leads to disruption of carotenoid-based pigmen-tation, reduced fertility, and a decreased larvae survival rate, whereas steroidogenesis was unaltered. The observed reduced fertility is driven by defects in female fertility (-50 %, p < 0.001). Importantly, these alter-ations were independent of changes in free (wild-type 2.4 +/- 0.2 mu g/mu l versus scarb1-/-2.0 +/- 0.1 mu g/mu l) as well as total (wild-type 4.2 +/- 0.4 mu g/mu l versus scarb1-/-4.0 +/- 0.3 mu g/mu l) plasma cholesterol levels. Uptake of HDL in the liver of scarb1- /-zebrafish larvae was reduced (-86.7 %, p < 0.001), but this coincided with reduced perfusion of the liver. No effect was observed on lipoprotein uptake in the caudal vein. SCARB1 deficient ca-naries, which also lack carotenoids in their plumage, similarly as scarb1-/-zebrafish, failed to show an increase in plasma free-and total cholesterol levels. Conclusion: Our findings suggest that the specific function of SCARB1 in maintaining plasma cholesterol could be an evolutionary novelty that became prominent in mammals, while other known functions were already present earlier during vertebrate evolution.
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- 2023
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13. A procedure for the estimation of the numerical uncertainty of CFD calculations based on grid refinement studies
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Eça, L. and Hoekstra, M.
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- 2014
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14. The HepHIV 2017 Conference in Malta: joining forces for the earlier diagnosis of HIV and viral hepatitis
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Raben, D, Hoekstra, M, Sperle, I, Amato Gauci, AJ, Gauci, C, West, B, Sullivan, A, Lazarus, JV, Platteau, T, Rockstroh, JK, von Lingen, Ann‐Isabelle, Schatz, Eberhard, Godfrey, Fiona, Galea, George, Lundgren, Jens D, de Wit, John, Maistat, Ludmila, Donoghoe, Martin, Kaye, Per, Damme, Pierre, Mauss, Stefan, Reic, Tatjana, Zuilhof, Wim, Casabona, ordi, Dedes, Nikos, Delpech, alerie, Gatell, osé, Gazzard, Brian, Matičič, Mojca, Pol, Stanislas, Sönnerborg, Anders, and Tsereteli, Nino
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- 2018
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15. 2-Hydroxypropyl-beta-cyclodextrin treatment does not induce atherosclerotic lesion regression in Western-type diet-fed apolipoprotein E knockout mice
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Snip, O.S.C., Hoekstra, M., Zhang, Y., Geerling, J.J., and Eck, M. van
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Mice, Inbred C57BL ,Mice ,Cholesterol ,Mice, Knockout, ApoE ,Thioglycolates ,Animals ,ATP-Binding Cassette Transporters ,Atherosclerosis ,cyclodextrin ,cholesterol efflux ,macrophages ,atherosclerosis regression ,mouse model ,Molecular Biology ,Biochemistry ,2-Hydroxypropyl-beta-cyclodextrin ,ATP Binding Cassette Transporter 1 - Abstract
2-Hydroxypropyl-beta-cyclodextrin (2HP beta CD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic cardiovascular disease. However, conflicting results regarding the potential of 2HP beta CD to induce regression of established atherosclerotic lesions have been described. In the current study, we therefore also investigated the ability of 2HP beta CD to stimulate cholesterol removal from macrophage foam cells in vitro and induce the regression of established atherosclerotic lesions in apolipoprotein E knockout (APOE KO) mice. In vitro studies using murine thioglycollate-elicited peritoneal macrophages verified that 2HP beta CD is able to induce cholesterol efflux from macrophages in an ATP-binding cassette transporter-independent manner. Switching Western-type-diet-fed APOE KO mice with established atherosclerotic lesions back to a chow diet was associated with a reduction in the hypercholesterolemia extent and an increase in the absolute lesion size and plaque collagen-to-macrophage ratio. Importantly, parallel subcutaneous administration of 2HP beta CD was not able to prevent the diet-switch-associated lesion growth or induce atherosclerosis regression. Although in our hands, 2HP beta CD does effectively stimulate cellular cholesterol efflux from macrophages, we do not consider it worthwhile to further pursue 2HP beta CD as therapeutic moiety in the atherosclerosis regression context.
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- 2022
16. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016
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Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Creagh-Brown, B., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., de Lange, D. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., Peelen, L. M., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Christopher, K. 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S., Lozano, A., Lheureux, O., Badenes, R., Vincent, J. L., Creteur, J., Taccone, F. S., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Vincent, J. L., Creteur, J., Taccone, F. S., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Geeraerts, T., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Rubulotta, F., Waldauf, P., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. Vieira, Amarante, G., Skorko, A., Sanders, S., Aron, J., Kroll, R. J., Redfearn, C., Krishnan, P., Khalil, J. E., Kovari, F., Kongpolprom, N., Gulia, V., Lourenço, E., Melão, L., Duro, C., Baptista, G., Alves, A., Arminda, B., Rodrigues, M., Marreiros, A., Granja, C., Hayward, J., Baldwin, F., Gray, R., Katinakis, P. A., Stijf, M., Ten Kleij, M., Jansen-Frederiks, M., Broek, R., de Bruijne, M., Spronk, P. 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R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., Rubulotta, F., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Cánovas, J., Sotos, F., López, A., Lorente, M., Burruezo, A., Torres, D., Polok, K., Włudarczyk, A., Górka, J., Hałek, A., Musiał, J., Szczeklik, W., Jazia, A. Ben, Jaziri, F., Bargouth, M., Bennasr, M., Turki, S., Abdelghani, K. Ben, Abdallah, T. Ben, de Grooth, H. J., Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Wykes, K., Jack, J., Morgan, P., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Espinoza, E. D. Valenzuela, Welsh, S. P., Motta, M. F., Guerra, E., Zerpa, M. C. l., Zechner, F., Furche, M., Berdaguer, F., Birri, P. N. Rubatto, Risso-Vazquez, A., Dubin, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Sánchez-Hurtado, L. A., Arvizu-Tachiquín, P. C., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Baltazar-Torres, J. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Poulose, V., Morales, M. A. Lopez, Castro, S., Pires, T., Melão, L., Krystopchuk, A., Pereira, I., Granja, C., Taniguchi, L. U., Pires, E. M. C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA
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- 2016
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17. Angiopoietin-like 3 (ANGPTL3) resides on HDL and LDL with the latter form having the highest lipase inhibitory activity
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Tromp, T.R., primary, Reeskamp, L.F., additional, Langenkamp, M., additional, Levels, J.H.M., additional, Hoekstra, M., additional, Hovingh, G.K., additional, and Grefhorst, A., additional
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- 2022
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18. Messy victims and sympathetic offenders: the role of moral judgments in police referrals to restorative justice
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Hoekstra, M. S., primary
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- 2022
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19. Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation
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Hoekstra, M., Liu, Q., Zhang, Y.H., Wel, E.J. van der, Le Devedec, S.E., and Eck, M. van
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Steroidogenesis ,Adrenal: Glucocorticoid ,Lipoprotein Metabolism ,Phospholipid Transfer Protein - Abstract
Objectives: Glucocorticoids, adrenal-derived steroid hormones, facilitate the physiological response to stress. High-density lipoproteins (HDL) are considered the primary source of cholesterol used for glucocorticoid synthesis in mice. Phospholipid transfer protein (PLTP) is a key player in HDL formation. In the current study we tested the hypothesis that HDL deficiency associated with genetic lack of PLTP negatively impacts the adrenal steroid function. Methods: We determined the glucocorticoid response to overnight food deprivation stress and the adrenal lipid and genetic phenotype of wild-type and PLTP knockout mice. Results: Basal plasma corticosterone levels, adrenal weights, and adrenocortical neutral lipid stores were not different between wild-type and PLTP knockout mice. Strikingly, plasma corticosterone levels were also equally high in the two groups of mice under fasting conditions (twoway ANOVA genotype effect: P>0.05). However, compensatory mechanisms were active to overcome adrenal lipid depletion, since gene expression levels of cholesterol synthesis, acquisition and mobilization proteins were similar to 2-fold higher in PLTP knockout adrenals versus wild-type adrenals. In support of an overall similar glucocorticoid stress response, hepatic relative mRNA expression levels of the glucocorticoid receptor target/glucocorticoid-sensitive genes PEPCK, ANGPTL4, FGF21, TDO2 and HMGCS2 were also not different. Conclusions: We have shown that hypocholesterolemic PLTP knockout mice exhibit a normal glucocorticoid response to food deprivation. These novel data (1) highlight that the effect of HDL deficiency on adrenal glucocorticoid output in mice is model dependent and (2) imply that other (lipoprotein) cholesterol sources than HDL can also generate the pool utilized by adrenocortical cells to synthesize glucocorticoids.
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- 2022
20. The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth
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Christenson, E., DeMaggio, A. J., Hoekstra, M. F., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Müller-Hermelink, H. K., editor, Neumann, H.-G., editor, and Dekant, W., editor
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- 1997
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21. Speeding Up the Healing of Burns with Honey : An Experimental Study with Histological Assessment of Wound Biopsies
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Postmes, Th. J., Bosch, M. M. C., Dutrieux, R., van Baare, J., Hoekstra, M. J., Mizrahi, Avshalom, editor, and Lensky, Yaacov, editor
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- 1997
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22. Phenotype of Cells Migrated from Human Skin Explants
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Richters, C. D., Hoekstra, M. J., Hoefsmit, E. C. M., Kamperdijk, E. W. A., Banchereau, Jacques, editor, and Schmitt, Daniel, editor
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- 1995
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23. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016
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Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. 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C., Ince, Y., Ince, C., Balik, M., Zakharchenko, M., Los, F., Brodska, H., de Tymowski, C., Augustin, P., Desmard, M., Montravers, P., Stapel, S. N., de Boer, R., Oudemans, H. M., Hollinger, A., Schweingruber, T., Jockers, F., Dickenmann, M., Siegemund, M., Runciman, N., Ralston, M., Appleton, R., Mauri, T., Alban, L., Turrini, C., Sasso, T., Langer, T., Panigada, M., Taccone, P., Carlesso, E., Marenghi, C., Grasselli, G., Pesenti, A., Wibart, P., Reginault, T., Garcia, M., Barbrel, B., Benard, A., Bader, C., Vargas, F., Bui, H. N., Hilbert, G., Simón, J. M. Serrano, Sánchez, P. Carmona, Ferrón, F. Ruiz, de Acilu, M. García, Marin, J., Antonia, V., Ruano, L., Monica, M., Ferrer, R., Masclans, J. R., Roca, O., Hong, G., Kim, D. H., Kim, Y. S., Park, J. S., Jee, Y. K., xiang, Z. Yu, Jia-xing, W., dan, W. Xiao, long, N. Wen, Yu, W., Yan, Z., Cheng, X., Kobayashi, T., Onodera, Y., Akimoto, R., Sugiura, A., Suzuki, H., Iwabuchi, M., Nakane, M., Kawamae, K., Sanchez, P. Carmona, Rodriguez, M. D. Bautista, Delgado, M. Rodriguez, Sánchez, V. Martínez de Pinillos, Gómez, A. Mula, Simón, J. M. Serrano, Beuret, P., Fortes, C., Lauer, M., Reboul, M., Chakarian, J. C., Fabre, X., Philippon-Jouve, B., Devillez, S., Clerc, M., Rittayamai, N., Sklar, M., Dres, M., Rauseo, M., Campbell, C., West, B., Tullis, D. E., Brochard, L., Onodera, Y., Akimoto, R., Suzuki, H., Okada, M., Nakane, M., Kawamae, K., Ahmad, N., Wood, M., Glossop, A., Lucas, J. Higuera, Ortiz, A. Blandino, Alonso, D. Cabestrero, De Pablo Sánchez, R., González, L. Rey, Costa, R., Spinazzola, G., Pizza, A., Ferrone, G., Rossi, M., Antonelli, M., Conti, G., Ribeiro, H., Alves, J., Sousa, M., Reis, P., Socolovsky, C. S., Cauley, R. P., Frankel, J. E., Beam, A. L., Olaniran, K. O., Gibbons, F. K., Christopher, K. B., Pennington, J., Zolfaghari, P., King, H. S., Kong, H. H. Y., Shum, H. P., Yan, W. W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
- Published
- 2016
- Full Text
- View/download PDF
24. A Tn3 Derivative that can be Used to Make Short In-Frame Insertions within Genes
- Author
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Hoekstra, M. F., Burbee, D., Singer, J., Mull, E., Chiao, E., and Heffron, F.
- Published
- 1991
25. Black box online monitoring bij gemeenten onderzocht: Een wankel fundament onder een stevige praktijk
- Author
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Bantema, W., Westers, S., Hoekstra, M., Herregodts, Rianne, Munneke, Solke, and Public Trust and Public Law
- Published
- 2021
26. Preventive effects of selected probiotic strains on the development of asthma and allergic rhinitis in childhood. The Panda study
- Author
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Gorissen, D. M. W., Rutten, N. B. M. M., Oostermeijer, C. M. J., Niers, L. E. M., Hoekstra, M. O., Rijkers, G. T., and van der Ent, C. K.
- Published
- 2014
- Full Text
- View/download PDF
27. Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in the Netherlands: the PIAMA birth cohort study
- Author
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Pinelli, E., Willers, S. M., Hoek, D., Smit, H. A., Kortbeek, L. M., Hoekstra, M., de Jongste, J., van Knapen, F., Postma, D., Kerkhof, M., Aalberse, R., van der Giessen, J. W. B., and Brunekreef, B.
- Published
- 2009
- Full Text
- View/download PDF
28. Patient Characteristics As Predictors of Clinical Outcome of Distraction in Treatment of Severe Ankle Osteoarthritis
- Author
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Marijnissen, A. C.A., Hoekstra, M. C.L., du Pré, B. C., van Roermund, P. M., van Melkebeek, J., Amendola, A., Maathuis, P., Lafeber, F. P.J.G., and Welsing, P. M.J.
- Published
- 2014
- Full Text
- View/download PDF
29. On the numerical accuracy of the prediction of resistance coefficients in ship stern flow calculations
- Author
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Eça, L. and Hoekstra, M.
- Published
- 2009
- Full Text
- View/download PDF
30. Development of a dermal matrix from glycerol preserved allogeneic skin
- Author
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Richters, C. D., Pirayesh, A., Hoeksema, H., Kamperdijk, E. W. A., Kreis, R. W., Dutrieux, R. P., Monstrey, S., and Hoekstra, M. J.
- Published
- 2008
- Full Text
- View/download PDF
31. The numerical friction line
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Eça, L. and Hoekstra, M.
- Published
- 2008
- Full Text
- View/download PDF
32. Verification of RANS solvers with manufactured solutions
- Author
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Eça, L., Hoekstra, M., Hay, A., and Pelletier, D.
- Published
- 2007
- Full Text
- View/download PDF
33. The influence of a PHI-5-loaded silicone membrane, on cutaneous wound healing in vivo
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van Rossum, M., Vooijs, D. P. P., Walboomers, X. F., Hoekstra, M. J., Spauwen, P. H. M., and Jansen, J. A.
- Published
- 2007
- Full Text
- View/download PDF
34. Identification of scavenger receptor BI as a potential screening candidate for congenital primary adrenal insufficiency in humans
- Author
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Hoekstra, M.
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Physiology ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Hypoglycemia ,Primary Adrenal Insufficiency ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Addison Disease ,Corticosterone ,Physiology (medical) ,Internal medicine ,Animals ,Humans ,Medicine ,Genetic Testing ,Scavenger receptor ,Glucocorticoids ,Mice, Knockout ,business.industry ,Scavenger Receptors, Class B ,medicine.disease ,SCARB1 ,Steroid hormone ,Cholesterol ,030104 developmental biology ,Endocrinology ,chemistry ,Cholesterol Esters ,Lipoproteins, HDL ,business ,Glucocorticoid ,medicine.drug ,Hormone - Abstract
Glucocorticoids belong to the superfamily of steroid hormones that are synthesized from the common precursor cholesterol. Adrenal gland-derived glucocorticoids, e.g., cortisol in humans and corticosterone in rodents, contribute to various processes essential for normal daily life. Glucocorticoid deficiency, also referred to as primary adrenal insufficiency, therefore, often becomes evident early in life and can be present with hypoglycemia, a failure to thrive, recurrent development of infections, and neurological problems, such as seizures and coma. The majority of congenital primary adrenal insufficiency cases are caused by deleterious mutations in genes involved in the intracellular mobilization of cholesterol and the subsequent conversion of cholesterol into glucocorticoids. A significant number of glucocorticoid deficiency cases, however, cannot be explained by known genetic variations. This perspective highlights existing literature regarding the importance of lipoprotein-derived cholesterol acquisition through scavenger receptor class B, type I (SR-BI/SCARB1) for the maintenance of an optimal adrenal glucocorticoid function in mice and humans. On the basis of the reviewed findings, it is suggested that the SCARB1 gene should be included in the standard glucocorticoid deficiency genetic screening panel to 1) facilitate knowledge development on the relative contribution of SR-BI-mediated cholesterol acquisition to steroid hormone synthesis in humans and 2) open up the possibility to reclassify glucocorticoid deficiency patients without a currently known genetic cause for concomitant treatment optimization.
- Published
- 2020
35. Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease
- Author
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Sluis, R.J. van der and Hoekstra, M.
- Subjects
0301 basic medicine ,Metabolic disease ,030209 endocrinology & metabolism ,Disease ,Bioinformatics ,Biochemistry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Glucocorticoid ,ATHEROSCLEROSIS SUSCEPTIBILITY ,medicine ,Animals ,Humans ,Molecular Targeted Therapy ,Glucocorticoids ,Molecular Biology ,Metyrapone ,Cholesterol ,Atherosclerotic cardiovascular disease ,business.industry ,Scavenger receptor BI ,Atherosclerosis ,Cardiovascular disease ,Disease Models, Animal ,030104 developmental biology ,Hypercortisolemia ,chemistry ,Cardiovascular Diseases ,business ,Homeostasis ,medicine.drug - Abstract
Adrenal-derived glucocorticoids mediate the physiological response to stress. Chronic disturbances in glucocorticoid homeostasis, i.e. in Addison's and Cushing's disease patients, predispose to the development of atherosclerotic cardiovascular disease. Here we review preclinical and clinical findings regarding the relation between changes in plasma glucocorticoid levels and the atherosclerosis extent. It appears that, although the altered glucocorticoid function can in most cases be restored in the different patient groups, current therapies do not necessarily reverse the associated risk for atherosclerotic cardiovascular disease. In our opinion much attention should therefore be given to the development of a Cushing's disease mouse model that can (1) effectively replicate the effect of hypercortisolemia on atherosclerosis outcome observed in humans and (2) be used to investigate, in a preclinical setting, the relative impact on atherosclerosis susceptibility of already available (e.g. metyrapone) and potentially novel (i.e. SR-BI activity modulators) therapeutic agents that target the adrenal glucocorticoid output.
- Published
- 2020
36. A call to action toward integrated testing and earlier care for viral hepatitis, HIV, STIs and TB
- Author
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Raben, D, Hoekstra, M, Combs, L, Sullivan, AK, Lazarus, JV, Lambert, JS, Simões, D, Streinu-Cercel, A, Rockstroh, JK, Amato-Gauci, A, Pop, CS, Oprea, C, Hedrich, D, Gökengin, D, Schatz, E, Ghita, E, Rockstroh, J, Tavochi, L, Cosmaro, L, Ursan, M, Dara, M, Dascalu, N, Dedes, N, Baptista Leite, R, Pasanen, S, Reic, T, Platteau, T, Grecu, V, Sönnerborg, A, Gazzard, B, West, B, Karpov, I, Lundgren, JD, de Wit, J, Casabona, J, Maistat, L, Matičič, M, Tsereteli, N, Pol, S, Delpech, V, Zuilhof, W, Yazdanpanah, Y, Azad, Y, Pharris, A, Noori, T, Mozalevskis, A, Vovc, E, Fenton, K, Kakalou, C, Klavs, I, Wawer, I, Hristojeva, J, Kivimets, K, Maffeo, M, Kall, M, Mommi, M, Gasbarrini, N, Wysocki, P, Koutkias, V, and Instituto de Saúde Pública da Universidade do Porto
- Subjects
medicine.medical_specialty ,business.industry ,diagnosis ,Health Policy ,Human immunodeficiency virus (HIV) ,HIV ,viral hepatitis ,Hiv stis ,medicine.disease_cause ,medicine.disease ,testing ,Call to action ,Infectious Diseases ,Family medicine ,Medicine ,Pharmacology (medical) ,business ,Viral hepatitis ,sexually transmitted infections - Abstract
Objectives. The objective of the paper is to present the outcomes of the HepHIV 2019 conference, held in Bucharest under the Romanian EU Presidency and focusing on challenges of timely and integrated testing and care. Methods. The conference programme was put together by the organizing committee. It consisted of invited talks and peer-reviewed abstracts. Results. In all, 65 abstracts from 20 countries were presented during the conference, which had nearly 250 delegates, including high-profile political representation. The conference highlighted the need to shift towards further disease integration because of the epidemiological characteristics of the hepatitis B (HBV), hepatitis C (HCV), HIV, sexually transmitted infection (STIs) and tuberculosis (TB) epidemics in the WHO European region. Integration should be a priority in the response to the epidemics to better reach key populations and to ensure better testing coverage. This relates to both the integration of services in shared care models and the integration of different settings and stakeholders in national strategies. Conclusions. The conference demonstrated the need for greater political support for the policy changes required to implement integration. Testing normalization efforts are key to maximizing the impact of integration efforts. The conference call to action can help to guide developments in testing and linkage-to-care interventions across the European region. The HepHIV 2019 Bucharest Conference was co-funded with the Health Programme of the European Union and the EU Health Project Symposium; Integrated Testing and Synergies was funded by the Health Programme of the European Union. The HepHIV 2019 Bucharest Conference was funded by the HIV in Europe/EuroTEST Initiative that received sponsorship funds for this purpose from Gilead, Merck MSD, ViiV Healthcare, Abbvie, Autotest Santé (AAZ-LMB), Cepheid, InTec, OraSure and SH:24. The funders had no role in the study design, analysis, decision to publish, or preparation of the manuscript.
- Published
- 2020
37. State-sponsored gentrification or social regeneration?: Symbolic politics and neighborhood intervention in an Amsterdam working-class neighborhood
- Author
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van Gent, W., Boterman, W., Hoekstra, M., Anacker, K.B., Nguyen, M.T., Varady, D.P., and Urban Geographies (UG, AISSR, FMG)
- Abstract
This chapter discusses state interventions in Van der Pekbuurt (VDP-buurt), a low-income former working-class neighborhood in Amsterdam. We focus on “quarter making,” which refers to policymakers catering to middle-class preferences through social policies, initiatives, and service provision, in anticipation of in-moving middle-class residents as part of regeneration and gentrification strategies. Introducing and facilitating cultural entrepreneurs and artists in the representation of what the neighborhood is, and ought to be, helps to move the area toward the policymakers’ future vision. As such, these representations undermine the legitimacy of long-term residents’ efforts and interests. Interviews with long-term residents reveal that the changes in the neighborhood instill a sense of loss of place, exacerbated by cuts in local service provision. For these reasons, state intervention in VDP-buurt constitutes a “soft force” approach to state-sponsored gentrification.
- Published
- 2020
38. Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome
- Author
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Biggar, K.K. (Kyle K.), Charih, F. (Francois), Liu, H. (Huadong), Ruiz-Blanco, Y.B. (Yasser B.), Stalker, L. (Leanne), Chopra, A. (Anand), Connolly, J. (Justin), Adhikary, H. (Hemanta), Frensemier, K. (Kristin), Hoekstra, M. (Matthew), Galka, M. (Marek), Fang, Q. (Qi), Wynder, C. (Christopher), Stanford, W.L. (William L.), Green, J. (James R.), Li, S.S.-C. (Shawn S.-C.), Biggar, K.K. (Kyle K.), Charih, F. (Francois), Liu, H. (Huadong), Ruiz-Blanco, Y.B. (Yasser B.), Stalker, L. (Leanne), Chopra, A. (Anand), Connolly, J. (Justin), Adhikary, H. (Hemanta), Frensemier, K. (Kristin), Hoekstra, M. (Matthew), Galka, M. (Marek), Fang, Q. (Qi), Wynder, C. (Christopher), Stanford, W.L. (William L.), Green, J. (James R.), and Li, S.S.-C. (Shawn S.-C.)
- Abstract
Protein Lys methylation plays a critical role in numerous cellular processes, but it is challenging to identify Lys methylation in a systematic manner. Here we present an approach combining in silico prediction with targeted mass spectrometry (MS) to identify Lys methylation (Kme) sites at the proteome level. We develop MethylSight, a program that predicts Kme events solely on the physicochemical properties of residues surrounding the putative methylation sites, which then requires validation by targeted MS. Using this approach, we identify 70 new histone Kme marks with a 90% validation rate. H2BK43me2, which undergoes dynamic changes during stem cell differentiation, is found to be a substrate of KDM5b. Furthermore, MethylSight predicts that Lys methylation is a prevalent post-translational modification in the human proteome. Our work provides a useful resource for guiding systematic exploration of the role of Lys methylation in human health and disease.Biggar et al. develop an algorithm to identify lysine methylation sites and use this resource to provide insight into the potential of the methyllysine proteome. The results also validate 45 new histone methylation sites by targeted mass spectrometry and show that one of these sites, H2B-K43me2, is a substrate of the KDM5B demethylase.
- Published
- 2020
- Full Text
- View/download PDF
39. Correction for: Niers et al. The effects of selected probiotic strains on the development of eczema (the PandA study)
- Author
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Niers, L., Martin, Robert R., Rijkers, Ger T., Sengers, F., Timmerman, H.M., Smidt, H., Kimpen, J.L.L., Hoekstra, M., Niers, L., Martin, Robert R., Rijkers, Ger T., Sengers, F., Timmerman, H.M., Smidt, H., Kimpen, J.L.L., and Hoekstra, M.
- Published
- 2020
40. Medicijnresten te lijf met (geavanceerde) oxidatie
- Author
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Delfos, B., Neut, R. van der, Hoekstra, M., Martijn, B., Delfos, B., Neut, R. van der, Hoekstra, M., and Martijn, B.
- Abstract
Met het traject Ge(O)zond Waterworden organische microverontreinigingen, met name medicijnresten, door oxidatie verwijderd uit effluent van RWZI Wervershoof. Onderzoek op laboratorium- en pilotschaal heeft uitgewezen dat ozonisatie van de effluentstroom toereikend is voor afbraak van de medicijnresten conform de beoogde normering. Tevens blijkt geavanceerde oxidatie, een combinatie van ozon en waterstofperoxide, verdergaande zuivering te realiseren. Hierbij blijft de vorming van bromaat ruim binnen de normen. Gesteund door deze resultaten bereidt Hoogheemraadschap Hollands Noorderkwartier een demoschaal-investering voor op de RWZI Wervershoof.
- Published
- 2020
41. De hygiënehypothese: een toenemende incidentie van allergische aandoeningen als gevolg van vaccinaties?
- Author
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Hoekstra, M. O. and Wolfs, T. F. W.
- Published
- 2005
- Full Text
- View/download PDF
42. Zuigelingenvoeding en allergie: preventie en behandeling van koemelkallergie bij jonge kinderen
- Author
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Kneepkens, C. M. F., Kapitein, B., Gevers, S., Meijer, Y., Vlieg, B., Neijens, H. J., and Hoekstra, M. O.
- Published
- 2004
- Full Text
- View/download PDF
43. Kinderen met astma en reflux
- Author
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Bekkali, N., van Aalderen, C. M. C., Benninga, M. A., Taminiau, J. A. J. M., and Hoekstra, M. O.
- Published
- 2004
- Full Text
- View/download PDF
44. Allergie op de kinderleeftijd – een rol voor primaire preventie
- Author
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Steenhuis, T. J., van Aalderen, W. M. C., and Hoekstra, M. O.
- Published
- 2003
- Full Text
- View/download PDF
45. Verification of calculations of the potential flow around two-dimensional foils
- Author
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Eca, L., Vaz, G.B., de Campos, J.A.C. Falcao, and Hoekstra, M.
- Subjects
Aerospace engineering -- Research ,Aerospace and defense industries ,Business - Abstract
An example of verification of calculations using methods based on grid-refinement studies and Richardson extrapolation is presented. The study is performed for numerical simulations of the potential flow around two-dimensional lifting foils by one low-order and two higher-order panel methods based on Morino's perturbation potential formulation. Flow's with known analytical solutions have been selected to assess the reliability of the uncertainty estimations. The grid-convergence index method is the basis for these estimations. Two options are compared: estimating the uncertainty of the solution on a specific grid and of the solution found by extrapolation to zero grid cell size. The results indicate that the uncertainty estimation in the former case is more reliable than in the latter.
- Published
- 2004
46. On the grid sensitivity of the wall boundary condition of the k-[omega] turbulence model
- Author
-
Eca, L. and Hoekstra, M.
- Subjects
Walls -- Research ,Turbulence -- Research ,Engineering and manufacturing industries ,Science and technology - Abstract
This paper presents a study on the k-[omega] to turbulence model with regard to the numerical implementation of the to boundary condition at a solid wall, where to tends to infinity. Three different implementations are tested in the calculation of a simple two-dimensional turbulent flow over a flat plate. Grid refinement studies in grids with different near-wall grid line spacings are performed to assess the numerical uncertainty of the predicted drag coefficient [C.sub.D]. The results are compared with the predictions of several alternative algebraic, one-equation, and two-equation eddy-viscosity turbulence models. For the same level of grid refinement, the estimated uncertainty of [C.sub.D] obtained with the k-[omega] model is one order of magnitude larger than for all the other models. [DOI: 10.1115/1.1845492]
- Published
- 2004
47. Perinatal risk factors for wheezing phenotypes in the first 8 years of life
- Author
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Caudri, D., Savenije, O. E. M., Smit, H. A., Postma, D. S., Koppelman, G. H., Wijga, A. H., Kerkhof, M., Gehring, U., Hoekstra, M. O., Brunekreef, B., and de Jongste, J. C.
- Published
- 2013
- Full Text
- View/download PDF
48. The case for indicator condition-guided HIV screening
- Author
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Lazarus, J V, Hoekstra, M, Raben, D, Delpech, V, Coenen, T, and Lundgren, J D
- Published
- 2013
- Full Text
- View/download PDF
49. Liver X receptor (LXR) activation influences murine platelet count only under normolipidemic conditions: PB 4.29–6
- Author
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Van Der Stoep, M, Li, Z, Van Der Sluis, R J, Van Berkel, T JC, Van Eck, M, Hoekstra, M, and Korporaal, S JA
- Published
- 2013
50. Liver X receptor (LXR) agonist T0901317 induces regression of early and advanced atherosclerotic lesions under normolipidemic conditions in mice: PB 1.32–1
- Author
-
Van Der Stoep, M, Li, Z, Calpe-Berdiel, L, Van Der Sluis, R J, McKinnon, H J, Smit, M J, Van Berkel, T JC, Van Eck, M, Hoekstra, M, and Korporaal, S JA
- Published
- 2013
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