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19 results on '"Hoekstra, Jurriaan"'

4. Genomic analysis of European bovine Staphylococcus aureus from clinical versus subclinical mastitis

Author

Hoekstra, Jurriaan, Zomer, Aldert L., Rutten, Victor P. M. G., Benedictus, Lindert, Stegeman, Arjan, Spaninks, Mirlin P., Bennedsgaard, Torben W., Biggs, Andrew, De Vliegher, Sarne, Mateo, Demetrio Herrera, Huber-Schlenstedt, Reglindis, Katholm, Jørgen, Kovács, Péter, Krömker, Volker, Lequeux, Guillaume, Moroni, Paolo, Pinho, Luís, Smulski, Sebastian, Supré, Karlien, Swinkels, Jantijn M., Holmes, Mark A., Lam, Theo J. G. M., and Koop, Gerrit

Published
2020
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5. Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Loef, Bette, Herber, Gerrie Cor M., Wong, Albert, Janssen, Nicole A.H., Hoekstra, Jurriaan, Picavet, H. Susan J., Verschuren, W. M.Monique, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Loef, Bette, Herber, Gerrie Cor M., Wong, Albert, Janssen, Nicole A.H., Hoekstra, Jurriaan, Picavet, H. Susan J., and Verschuren, W. M.Monique

Published
2023

6. Predicting self-perceived general health status using machine learning: an external exposome study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Hoekstra, Jurriaan, Lenssen, Esther S, Wong, Albert, Loef, Bette, Herber, Gerrie-Cor M, Boshuizen, Hendriek C, Strak, Maciek, Verschuren, W M Monique, Janssen, Nicole A H, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Hoekstra, Jurriaan, Lenssen, Esther S, Wong, Albert, Loef, Bette, Herber, Gerrie-Cor M, Boshuizen, Hendriek C, Strak, Maciek, Verschuren, W M Monique, and Janssen, Nicole A H

Published
2023

8. Additional file 8 of Predicting self-perceived general health status using machine learning: an external exposome study

Author

Hoekstra, Jurriaan, Lenssen, Esther S., Wong, Albert, Loef, Bette, Herber, Gerrie-Cor M., Boshuizen, Hendriek C., Strak, Maciek, Verschuren, W. M. Monique, and Janssen, Nicole A. H.

Abstract

Additional file 8: Figure S1. Partial dependance plots of a selection of top ranked categorical variables within a random forest model to predict self-perceived general health status. Figure S2. Accumulated local effects plots of a selection of top continuous variables within a random forest model to predict self-perceived general health status.

Published
2023
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11. Using random forest to identify longitudinal predictors of health in a 30-year cohort study

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Loef, Bette, Wong, Albert, Janssen, Nicole A.H., Strak, Maciek, Hoekstra, Jurriaan, Picavet, H. Susan J., Boshuizen, H. C.Hendriek, Verschuren, W. M.Monique, Herber, Gerrie Cor M., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Loef, Bette, Wong, Albert, Janssen, Nicole A.H., Strak, Maciek, Hoekstra, Jurriaan, Picavet, H. Susan J., Boshuizen, H. C.Hendriek, Verschuren, W. M.Monique, and Herber, Gerrie Cor M.

Published
2022

12. Genomic analysis of European bovine Staphylococcus aureus from clinical versus subclinical mastitis

Author

dFAH I&I, Klinische infectiologie en microb. lab., dI&I I&I-4, Immunologie, dI&I RA-I&I I&I, LS Immunologie, FAH veterinaire epidemiologie, dFAH AVR, Hoekstra, Jurriaan, Zomer, Aldert L, Rutten, Victor P M G, Benedictus, Lindert, Stegeman, Arjan, Spaninks, Mirlin P, Bennedsgaard, Torben W, Biggs, Andrew, De Vliegher, Sarne, Mateo, Demetrio Herrera, Huber-Schlenstedt, Reglindis, Katholm, Jørgen, Kovács, Péter, Krömker, Volker, Lequeux, Guillaume, Moroni, Paolo, Pinho, Luís, Smulski, Sebastian, Supré, Karlien, Swinkels, Jantijn M, Holmes, Mark A, Lam, Theo J G M, Koop, Gerrit, dFAH I&I, Klinische infectiologie en microb. lab., dI&I I&I-4, Immunologie, dI&I RA-I&I I&I, LS Immunologie, FAH veterinaire epidemiologie, dFAH AVR, Hoekstra, Jurriaan, Zomer, Aldert L, Rutten, Victor P M G, Benedictus, Lindert, Stegeman, Arjan, Spaninks, Mirlin P, Bennedsgaard, Torben W, Biggs, Andrew, De Vliegher, Sarne, Mateo, Demetrio Herrera, Huber-Schlenstedt, Reglindis, Katholm, Jørgen, Kovács, Péter, Krömker, Volker, Lequeux, Guillaume, Moroni, Paolo, Pinho, Luís, Smulski, Sebastian, Supré, Karlien, Swinkels, Jantijn M, Holmes, Mark A, Lam, Theo J G M, and Koop, Gerrit

Published
2020

14. High Production of LukMF’ in Staphylococcus aureus Field Strains Is Associated with Clinical Bovine Mastitis

Author

Hoekstra, Jurriaan, Rutten, Victor, Sommeling, Laura, van Werven, Tine, Spaninks, Mirlin, Duim, Birgitta, Benedictus, Lindert, Koop, Gerrit, dFAH I&I, LS GZ Landbouwhuisdieren, dI&I RA-I&I I&I, LS Immunologie, LS Evidence Based Vet Medicine, dFAH AVR, Sub Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, dFAH I&I, LS GZ Landbouwhuisdieren, dI&I RA-I&I I&I, LS Immunologie, LS Evidence Based Vet Medicine, dFAH AVR, Sub Immunologie, LS Klinisch Onderzoek Wagenaar, and dI&I I&I-4

Subjects
0301 basic medicine, Staphylococcus aureus, Genotype, repressor of toxins, Health, Toxicology and Mutagenesis, Leukocidin, lcsh:Medicine, Virulence, Biology, Toxicology, medicine.disease_cause, Article, Microbiology, 03 medical and health sciences, Bacterial Proteins, phage, medicine, Journal Article, Animals, Mastitis, Bovine, Gene, Subclinical infection, Toxin, Point mutation, lcsh:R, bovine mastitis, clinical severity, LukMF’, phage encoded leukocidin, medicine.disease, Mastitis, encoded leukocidin, Milk, 030104 developmental biology, Cattle, Female, LukMF'
Abstract

Staphylococcus aureus, a major cause of bovine mastitis, produces a wide range of immune-evasion molecules. The bi-component leukocidin LukMF' is a potent killer of bovine neutrophils in vitro. Since the role of LukMF' in development of bovine mastitis has not been studied in natural infections, we aimed to clarify whether presence of the lukM-lukF' genes and production levels of LukMF' are associated with clinical severity of the disease. Staphylococcus aureus was isolated from mastitis milk samples (38 clinical and 17 subclinical cases) from 33 different farms. The lukM-lukF' genes were present in 96% of the isolates. Remarkably, 22% of the lukM-lukF'-positive S. aureus isolates displayed a 10-fold higher in vitro LukMF' production than the average of the lower-producing ones. These high producing isolates were cultured significantly more frequently from clinical than subclinical mastitis cases. Also, the detection of LukM protein in milk samples was significantly associated with clinical mastitis and high production in vitro. The high producing LukMF' strains all belonged to the same genetic lineage, spa-type t543. Analysis of their global toxin gene regulators revealed a point mutation in the Repressor of toxins (rot) gene which results in a non-functional start codon, preventing translation of rot. This mutation was only identified in high LukMF' producing isolates and not in low LukMF' producing isolates. Since rot suppresses the expression of various toxins including leukocidins, this mutation is a possible explanation for increased LukMF' production. Identification of high LukMF' producing strains is of clinical relevance and can potentially be used as a prognostic marker for severity of mastitis.

Published
2018
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17. Activation of a bovine mammary epithelial cell line by ruminant-associated staphylococcus aureus is lineage dependent

Author

MMB Research line 1, Infection & Immunity, Hoekstra, Jurriaan, Rutten, Victor P.M.G., Lam, Theo J.G.M., Van Kessel, Kok P.M., Spaninks, Mirlin P., Stegeman, J. Arjan, Benedictus, Lindert, Koop, Gerrit, MMB Research line 1, Infection & Immunity, Hoekstra, Jurriaan, Rutten, Victor P.M.G., Lam, Theo J.G.M., Van Kessel, Kok P.M., Spaninks, Mirlin P., Stegeman, J. Arjan, Benedictus, Lindert, and Koop, Gerrit

Published
2019

18. High Production of LukMF' in Staphylococcus aureus Field Strains Is Associated with Clinical Bovine Mastitis

Author

dFAH I&I, LS GZ Landbouwhuisdieren, dI&I RA-I&I I&I, LS Immunologie, LS Evidence Based Vet Medicine, dFAH AVR, Sub Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Hoekstra, Jurriaan, Rutten, Victor, Sommeling, Laura, van Werven, Tine, Spaninks, Mirlin, Duim, Birgitta, Benedictus, Lindert, Koop, Gerrit, dFAH I&I, LS GZ Landbouwhuisdieren, dI&I RA-I&I I&I, LS Immunologie, LS Evidence Based Vet Medicine, dFAH AVR, Sub Immunologie, LS Klinisch Onderzoek Wagenaar, dI&I I&I-4, Hoekstra, Jurriaan, Rutten, Victor, Sommeling, Laura, van Werven, Tine, Spaninks, Mirlin, Duim, Birgitta, Benedictus, Lindert, and Koop, Gerrit

Published
2018

19. Birth Outcomes among Infants Born between 2006 and 2018 after Maternal Exposure during Pregnancy to Ultrafine Particles from Aviation around a Large International Airport in the Netherlands.

Author

Jacobs JH, Nicolaie A, Strak M, Hoekstra J, de Vries EF, Wesseling J, Houthuijs D, and Janssen NAH

Subjects
Humans, Pregnancy, Female, Netherlands, Infant, Newborn, Adult, Premature Birth epidemiology, Aviation statistics & numerical data, Infant, Small for Gestational Age, Male, Air Pollution statistics & numerical data, Maternal Exposure statistics & numerical data, Particulate Matter analysis, Airports, Air Pollutants analysis, Pregnancy Outcome epidemiology
Abstract

Background: People who live near airports are exposed to higher concentrations of ultrafine particles (UFPs) from aviation. Pregnant women and their fetuses, in particular, are considered to be highly susceptible to environmental exposures., Objective: Using existing national databases, we investigated associations between adverse birth outcomes and exposure to UFPs from aviation (UFP-aviation) at the residential address during pregnancy., Methods: We identified ∼ 286,000 singleton birth records (from between 2006 and 2018) from mothers who, for at least 6 months during pregnancy, lived in a 50 × 56 km area around Schiphol Airport. This information was linked to modeled monthly averaged UFP-aviation concentrations at the residential address during pregnancy. We modeled the association between exposure to UFP-aviation during pregnancy and pregnancy outcomes through logistic regression, adjusting for individual and neighborhood level covariates. We performed a number of sensitivity analyses to investigate the robustness of the results, including adjustment for other air pollutants and noise., Results: Effect estimates, expressed per 3,500 particles/cm 3 (approximately the 5th-9th percentile difference) increase, were generally positive in the main model for preterm birth (PTB) and small for gestational age (SGA) [PTB OR = 1.02 (95% CI: 0.96, 1.07) and SGA OR = 1.02 (95% CI: 0.98, 1.07)] and congenital anomalies (CAs) at birth [any CA OR = 1.05 (95% CI: 0.98, 1.07)]. Associations with UFP-aviation became stronger in some of the sensitivity analyses, such as when the four municipalities with the lowest exposure were excluded (for PTB, SGA, and CA), when the population was restricted to mothers with a Dutch background (PTB), after nonlinear adjustment for nitrogen dioxide ( NO 2 ) and elemental carbon (EC) (PTB), after including municipality as a random effect (CA), and in some specific strata of the population. No associations were found with infant mortality, low Apgar score, and low birth weight., Conclusions: We found suggestive evidence for associations between exposure to UFP-aviation during pregnancy and pregnancy outcomes. https://doi.org/10.1289/EHP14398.

Published
2025
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