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3. 3rd IANA (International Academy on Nutrition and Aging) Meeting Nutrition, Exercise & Alzheimer and Clinical Trials on Sarcopenia August 1–2, 2008 Hyatt Regency Tamaya Resort 1300 Tuyuna Trail Santa Ana Pueblo, NM USA

Author

Andrieu, S., Barberger-Gateau, P., Raffaitin, C., Berr, C., Tzourio, C., Dartigues, J. -F., Gin, H., Fitten, L. J., Ortiz, F., Fairbanks, L., Bartzokis, G., Lu, P., Ringman, J., Heyn, P. C., Locher, J. L., Salvà, A., Andrieu, S., Fernández, E., Vellas, B., van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Beekman, A. T. F., Hoefnagels, W. H. L., de Groot, C. P. G. M., Angevaren, M., Aufdemkampe, G., Verhaar, H. J. J., Aleman, A., Vannees, L., Arkin, S., Florez, H., Gerstein, H., Sheridan, P., Bosch, J., Goldberg, R., Kaspar, K. M., Drawert, S. M., Marcus, R. L., Kidde, J., Dibble, L., Addison, O., LaStayo, P. C., Scarmeas, N., Stern, Y., Schupf, N., Luchsinger, J. A., Sharkey, J. R., Laditka, J. N., Laditka, S. B., Liu, R., Hochhalter, A., Robare, J. F., Türner, N., Judge, M., Foster, T. C., Erdos, B., Cudykier, I., Scarpace, P. J., Weiss, L. A., Bergstrom, J., Kritz-Silverstein, D., Barrett-Connor, Elizabeth, Yurko-Mauro, K., Nelson, E., Quinn, J., Sattler, F. R., Castaneda-Sceppa, C., Binder, E. F., Schroeder, E. T., Wang, Y., Bhasin, S., Kawakubo, M., Stewart, Y., Hahn, C., Colletti, P., Roubenoff, R., Yarasheski, K. E., Azen, S. P., Aoki, Y., Yamamoto, T., Otuka, T., Blanc-Bisson, C., Bourdel-Marchasson, I., Bocock, M. A., Keller, H. H., Bowman, G., Baxter, J., Oken, B., Frei, B., Traber, M., Leonard, S., Kaye, J., Shannon, J., Quinn, J., Carlsson, M., Gustafson, Y., Eriksson, S., Littbrand, H., Håglin, L., Danthiir, V., Wilson, C., Nettelbeck, T., Burns, N., Wittert, G., Noakes, M., Clifton, P., DiMaria-Ghalili, R. A., Grieger, J. A., Nowson, C. A., Wattanapenpaiboon, N. T., Holstein, J., Robinson, C., Hartmann, C., Rueb, S., Heffel, L., Dintaman, S., Reynolds, J., Fleming, L., Crull, M., Goldey, J., Serper, L. L., Hubbard, R., Westengard, J., Horning, M., Ishige, Y., Aoki, Y., Keller, H. H., Keller, H. H., LaStayo, P. C., Marcus, R. L., Smith, S., Kidde, J., Dibble, L., Butler, C., Hill, M., LaStayo, P. C., Marcus, R. L., Dibble, L., Kidde, J., Peters, C., Meier, W., Laughlin, G. A., Kritz-Silverstein, D., von Muhlen, D., Barrett-Connor, E., Olariu, L., Petcu, M., Tulcan, C., Pup, M., Otilingam, P., Gate, M., Pasinetti, G. M., Ray, B., Chauhan, N. B., Bailey, J. A., Lahiri, D. K., Shatenstein, B., Kergoat, M. -J., Reid, I., Chicoine, M. -E., Vaz, L., Stewart, R., Sabbah, W., Tsakos, G., D’Aiuto, F., Watt, R. G., Sturman, M., Kelly, J., Fleischman, D., Leurgans, S., Bennett, D., Morris, M. C., Suominen, M. H., Muurinen, S., Soini, H., Pitkälä, K. H., Yamamoto, T., Fujinoki, C., and Aoki, Y.

Published
2008
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7. Royal academy of medicine in Ireland international conference on homocysteine metabolism from basic science to clinical medicine: Proceedings of meeting held at Dromoland Castle, Co. Clare on July 2nd–6th, 1995

Author

Björkegren, K., Bergmark, C., de Faire, U., Mansoor, M. Azam, Svardal, A., Bostom, A. G., Roubenoff, R., Dellaripa, P., Nadeau, M. R., Sutherland, P., Wilson, P. W. F., Jacques, P. F., Selhub, J., Rosenberg, I. H., Bostom, A. G., Brosnan, J. T., Hall, B., Nadeau, M. R., Selhub, J., Bostom, A. G., Shemin, D., Lapane, K. L., Sutherland, P., Nadeau, M. R., Wilson, P. W. F., Selhub, J., Bostom, A. G., Shemin, D., Nadeau, M. R., Selhub, J., Bostom, A. G., Selhub, J., Jacques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., Cuskelly, G. J., McNulty, H., Strain, J. J., McPartlin, J. M., Scott, J. M., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Coudé, M., Aral, B., Zabot, M. T., Aupetit, J., Kamoun, P., Chadefaux-Vekemans, B., Calaf, R., Ghiringelli, O., Barlatier, A., Charpiot, P., Rolland, P. H., Garçon, D., Charpiot, P., Augier, T., Chareyre, C., Rolland, P. H., Garçon, D., Chango, A., Hodez, F., Tronel, H., Nuel, G., Michel, F., Frémont, S., Méjean, L., Nicolas, J. P., Candito, M., Chambon, P., Gibelin, P., Amsellem, J., Baudouy, M., Morand, P., Candito, M., Chambon, P., Pringuey, D., Aubin-Brunet, V., Beaulieu, F., Darcourt, G., Bedoucha, P., Alchaar, H., Chatel, M., Candito, M., de Valk, H. W., van der Griend, R., Eeden, M. K. G. van, de Groot, E., Duran, M., Smeitink, J. A. M., de Klerk, J. B. C., Wittebol-Post, D., Rolland, M. -O., Haas, F. J. L. M., Meuwissen, O. J. A. Th., Banga, J. D., Poll-The, B. T., de Vries, J. I. P., Dekker, G. A., van Geijn, H. P., Huigens, P. C., Jakobs, C., von Blomberg, B. M. E., Deulofeu, R., Giralt, M., Aibar, C., Bauchet, C., Ballesta, A. M., Varela, G., Vila, N., Chamorro, A., Casals, F. J., Cremades, J. Diaz, Daly, L., Meleady, R., Graham, I., den Heijer, M., Brouwer, I. A., Gerrits, W. B. J., Bos, G. M. J., Blom, H. J., den Heijer, M., Bos, G. M. J., Koster, T., Vandenbroucke, J. P., Blom, H. J., Briët, E., Rosendaal, F. R., Fischer, G., Behrend, C., Bartholmes, P., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Franken, D. G., Boers, G. H. J., Blom, H. J., Hamel, B. C. J., Franken, D. G., Boers, G. H. J., Blom, H. J., Ruijs, J. H. J., Franken, D. G., Blom, H. J., Boers, G. H. J., Tangerman, A., Guttormsen, A. B., Ueland, P. M., Refsum, H., Svarstad, E., Gao, W., Goldman, E., Jakubowski, H., Sebastio, G., Sperandeo, M. P., de Franchis, R., Andria, G., Garrow, T. A., Hladovec, J., Sommerova, Z., Písariková, A., Halsted, C. H., Villanueva, J., Chandler, C. J., Stabler, S. P., Allen, R. H., Muskhelishvili, L., James, S. J., Poirer, L., Jacobsen, D. W., Savon, S. R., DiCorleto, P. E., Jourdheuil-Rahmani, D., Rolland, P. H., Garçon, D., Joosten, E., Riezler, R., Allen, R., Joosten, E., Riezler, R., Allen, R., Marquardt, T., Ullrich, K., Harms, E., Koch, H. G., Koch, H. G., Evers, S., Grotemeyer, K. H., Vogelpohl, L., von Eckardstein, A., Ullrich, K., Deufel, T., Kraus, J., Harms, E., Kozich, V., Janosik, M., Sokolová, J., Bukovská, G., Kraus, J. P., Kluitmans, L. A. J., van den Heuvel, L. P., Stevens, E., Trubels, J. M. F., Blom, H. J., Boers, G. H. J., van Oost, B. A., Kraus, J. P., Kittner, S., Macko, R., Hebel, J. R., Rohr, J., Malinow, M. R., Upson, B., Buchholz, D., Earley, C., Johnson, C., Price, T. R., Rosario, J., Sloan, M., Stern, B., Wityk, R., Wozniak, M., Sherwin, R., Stolley, P., Kluijtmans, L., Heuvel, L. van den, Stevens, E., Trijbels, F., Blom, H., Boers, G., van Oost, B., den Heijer, M., Rozen, R., Löhrer, F., Angst, C., Fowler, B., Zaugg, M., Brunner, F., Haefeli, W. E., Nedrebø, B., Ericsson, U. -B., Ueland, P. M., Refsum, H., Lien, E. A., London, J., Paly, E., Paul, V., Paris, D., Kamoun, P., Chassé, J. F., Møller, J., Rasmussen, K., Meleady, R., Graham, I., Daly, L., Verhoef, P., Meleady, R., Graham, I., Daly, L., McMartin, K. E., Phifer, T. J., Alexander, J. S., Middlebrooks, M., Childress, L. E., Nicolas, J. P., Tronel, H., Chango, A., Fremont, S., Felden, F., Guerci, B., Creton, C., Drouin, P., Oakley, G. P., Elias, P. R. P., Hann, A. C., Curtis, C. G., Rose, F. A., Tudball, N., Parrot-Roulaud, F., Cochet, C., Catargi, B., Leprat, F., Latapie, J. -L., Perna, A. F., De Santo, N. G., Ingrosso, D., Galletti, P., Zappia, V., Parrot-Roulaud, F., Sassoust, G., Boissieras, P., Blom, H. J., Majors, A. K., Ehrhart, L. A., Pezacka, E. H., Perry, I. J., Morris, R. W., Ebrahim, S. B., Shaper, A. G., Refsum, H., Ueland, P. M., Pietrzik, K., Dierkes, J., Kroesen, M., Bung, P., Rasmussen, K., Moller, J., Rasmussen, K., Remacha, A., Garcia-Die, F., Cadafalch, J., Barceló, H. J., Parellada, H., Regland, B., Gottfries, C. -G., Andersson, M., Bagby, J., Dyrehag, L. -E., Abrahamsson, L., Ronge, E., Kjellman, B., Frosst, P., Christensen, B., Goyette, P., Rosenblatt, D. S., Genest, J., Rozen, R., Riedel, B., Ueland, P. M., Svardal, A. M., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X., Xie, L., Dudman, N., Smith, B., Kohlman-Trigoboff, D., Simsir, S., Stabler, S. P., Allen, R. H., Strydom, A. J. C., Schlüssel, E., Preibisch, G., Elstner, E. F. E., Pütter, S., Spuijbroek, M. D. E. H., Goddijn-Wessel, T. A. W., Wouters, M. G. A. J., Molen, E. F. v. d., Blom, H. J., Boers, G. H. J., Steegers-Theunissen, R. P. M., Trijbels, J. M. F., Thomas, C. M. G., Eskes, T. K. A. B., Tsai, M. Y., Hanson, N., Key, N., Schwichtenberg, K., Garg, U., Todesco, L., Fowler, B., Pollaert, N., Haefeli, W. E., Thorand, B., Hages, M., Pietrzik, K., Bung, P., Holzgreve, W., Vila, N., Chamorro, A., Deulofeu, R., Aibar, C., Giralt, M., Ballesta, A. M., van der Mooren, M. J., Wouters, M. G. A. J., Schellekens, L. A., Eskes, T. K. A. B., Rolland, R., Blom, H. J., Put, N. v. d., Trijbels, F., Heuvel, L. v. d., Blom, H., Eskes, T., Steegers-Theunissen, R., Mariman, E., Heyer, M. d., Rozen, R., Daher, R., Van Lente, F., Vilkovsky, A. B., Maev, I. V., Richter, E. L., Kirnus, M. D., Varela-Moreiras, G., Alonso-Aperte, E., Rubio, M., Gassó, M., Deulofeu, R., Alvarez, L., Caballeria, J., Rodés, J., Mato, J. M., van Aerts, L. A. G. J. M., Peereboom-Stegeman, J. H. J. Copius, Noordhoek, J., Eskes, T. K. A. B., Molen, E. F. v. d., Spuijbroek, M. D. E. H., Eskes, T. K. A. B., Heuvel, L. P. v. d., Monnens, L. A. H., Blom, H. J., van Guidener, C., Janssen, M. J. F. M., Surachno, J., Stehouwer, C. D. A., van den Berg, M., Bierdrager, E., Rauwerda, J. A., Wilcken, B., Hammond, J., Wouters, M. G. A. J., Hamilton, C. J. C. M., Blom, H. J., Boers, G. H. J., Thomas, C. M. G., Borm, G. F., Eskes, T. K. A. B., Wang, H., Tsai, J. -C., Perrella, M. A., Yoshizumi, M., Sibinga, N. E. S., Haber, E., Chang, T. H. -T., Schlegel, R., Lee, M. -E., Woodside, J., McMaster, D., Yarnell, J., Young, I., Mercer, C., Byrne, K., Evans, A., Gey, F., Gao, X. M., Dougan, G., Wordsworth, P., McMichael, A., Young, P. B., Kennedy, D. G., Molloy, A. M., Scott, J. M., Ward, P., Naughten, E., Cahalane, S., Murphy, D., Mayne, P., Chauveau, P., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Jungers, P., van Asselt, D. Z. B., Blom, H. J., de Wild, G. M., van Staveren, W. A., Hoefnagels, W. H. L., Naruszewicz, M., Staniewicz, A., Dziewanowski, K., Evrovski, J., Cole, D. E. C., Callaghan, Michael, Lindgren, A., Brattström, L., Hultberg, B., Verhoef, P., Hennekens, C. H., Allen, R. H., Stabler, S. P., Willett, W. C., Stampfer, M. J., Frantzen, F., Sundrehagen, E., Verhoef, P., Kok, F. J., Stampfer, M. J., Willett, W. C., Gaziano, J. M., Hennekens, C. H., Allen, R. H., Stabler, S. P., Reynolds, R. D., Hsu, R. -J., Shane, B., Robinson, K., Kottke-Marchant, K., Green, R., Gupta, A., Jacobsen, D., Robinson, K., Mayer, E., Gupta, A., Miller, D., Marchant, K., Green, R., Jacobsen, D., Greene, R., Chong, Y. -Y., Jacobsen, D., Robinson, K., Gupta, M., Sheppard, C. A., Matthews, R. G., Goyette, P., Frosst, P., Rozen, R., Verhoef, P., Kok, F. J., Kruyssen, H. A. C. M., Witteman, J. C. M., Ueland, P. M., Boushey, C., Beresford, S., Omenn, G., Motulsky, A. G., Nygard, O., Vollset, S. E., Kvale, G., Stensvold, I., Ueland, P. M., Refsum, H., Fiskerstrand, T., Ueland, P. M., Refsum, H., Bugge, K. H., Oshaug, A., Bjønnes, C. H., Refsum, H., Wu, J. T., Wu, L. L., and Wilson, L. W.

Published
1995
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13. Clinical pharmacological meeting

Author

Lubsen, J., Tijssen, J. G. P., Sluiter, H. E., Huysmans, F. Th. H., Thien, Th. A., Koene, R. A. P., Vincent, H. H., Derkx, F. H. M., Veld, A. J. Man in 't, Boomsma, F., Schalekamp, H. A. D. H., Hoefnagels, W. H. L., Lenders, J. W. M., Thien, Th., Smits, P., van 't Laar, A., v. Wijk, L. M., Kingma, J. H., Dunselman, P. H. J. M., v. Gilst, W. H., Lie, K. I., Wesseling, H., Lohman, J. J. H. M., Hooymans, P. M., Koten, M. L. P., Verhey, M. T. J. M., Merkus, F. W. H. M., Koopmans, P., Gribnau, F., Demacker, P., Jonkman, J. H. G., Van der Boon, W. J. V., Schoenmaker, R., Holtkamp, A., Hempenius, J., Edelbroek, P. M., Linssen, A. C. G., Zitman, F. G., Rooymans, H. G. M., de Wolff, F. A., Speth, P. A. J., Linssen, P. L. M., Wessels, J. H. C., Haanen, C., Elferink, F., van der Vijgh, W. J. F., van der Poort, S. E. J. M., Vermorken, J. B., Pinedo, H. M., Sonneveld, P., Nooter, K., van den Engh, G. J., Schurgers, N., de Blaey, C. J., and Crommelin, D. J. A.

Published
1984
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14. Abstracts of papers clinical pharmacological meeting

Author

Brink, H., Derkx, F., Kolstee, H., Merkus, P., Smits, J., Man in 't Veld, A., Schslekamp, M., Postma, C. T., Hoefnagels, W. H. L., Thien, Th., van Bortel, L. M. A. B., Böhm, R. O. B., Mooy, J. M. V., Schiffers, P. M. H., Rahn, K. H., Donker, A. J. M., Frydman, A., van Leerdam, F. J. H., de Vries, P. M. J. H., Oe, P. L., Chang, P. C., van Veen, S., Vermey, P., van Brummelen, P., Molema, J., Lammers, J. -W. J., Folgering, H. Th. M., van Herwaarden, C. L. A., de Boer, A., Stiekema, J. C. J., Danhof, M., Boei jinga, J. K., Breimer, D. D., Blauw, G. J., van Zwieten, P. A., Doorenbos, C. J., Daha, M. R., Hermans, W. A. J. J., Schüsler-van Hees, M. T. I. W., Merkus, F. W. H. M., Oldenhof, H. G. J., de Jong, M., Steenhoek, A., Janknegt, R., Koelman, J. H., Nube, M. J., Franssen, C., Wollersheim, H., Veering, B. Th., Burm, A. G. L., van Kleef, J. W., Hennis, P. J., Spierdijk, Joh, Bovill, J. G., Breimer, L. T. M., de Bruijn, E. A., Schouten, J., Smits, P., van 't Laar, A., van Baak, M. A., Koene, F., Verstappen, F. T. J., van der Krogt, J. A., and van Brumelen, P.

Published
1987
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15. Abstracts of papers

Author

Kleinbloesem, C. H., van Brummelen, P., van de Linde, J. A., Breimer, D. D., Kerremans, A. L. M., Cremers, H. J., Rodrigues de Miranda, J. F., van Ginneken, C. A. M., Gribnau, F. W. J., Schols, M., Mooy, J., van Hooff, M., van Baak, M. A., Rahn, K. H., Soeterboek, A. M., van Thiel, M., Westra, P., Vermeer, G. A., van Rooy, H. H., Pirovano, I. M., Soudijn, W., Lohman, J. J. H. M., Hooymans, P. M., Verhey, M. T. J. M., Pluym, B. F. M., Merkus, F. W. H. M., Thijssen, H. H. W., Baars, L. G., Reijnders, M. J., Wagenvoort, J. H. T., Fieren, M. W. J. A., Goessens, W. H. F., Michel, M. F., Edelbroek, P. M., Zitman, F. G., Schreuder, J. N., Rooymans, H. G. M., de Wolff, F. A., Hekster, Ch. A., Vree, T. B., van Baak, M. A., Jennen, W. H. J., Verstappen, F. T. J., Salemans, J., Lenders, J. W. M., Fennis, J., Thien, Th., Houben, H., Binkhorst, R. A., van 't Laar, A., Koopmans, P. P., van Hees, P. A. M., Hoefnagels, W. H. L., Huysmans, F. T. M., Woittiez, A. J. J., Wenting, G. J., Derkx, F. H. M., Schalekamp, M. A. D. H., Storms, G. E. M. G., Lutterman, J. A., de Nobel, E., van 't Laar, A., Sitsen, J. M. A., de Jong, W., Stuyt, P. M. J., Stalenhoef, A. F. H., Demacker, P. N. M., van 't Laar, A., Oosterhuis, B., Berge, R. J. M.ten, Sauerwein, N. P., Endert, E., Schellekens, P. Th. A., van Boxtel, C. J., Terpstra G. K., Raaijmakers, J. A. M., Wassink, G. A., Kreukniet, J., Bakker, J. C., de Vries-v. Rossen, A., Bleeker, W. K., Ufkes, J. G. R., van Rosevelt, R. F., van Mourik, J. A., Loos, J. A., Brummelhuis, H. G. J., Schalken, J. J., Lammers, J. W. J., Beld, A. J., and van Herwaarden, C. L. A.

Published
1983
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16. Abstracts of papers clinical pharmacological meeting

Author

van den Ouweland, F. A., Eenhoorn, P. C., Tan, Y., Gribnau, F. W. J., van Brupgen, A., de Graeff, P. A., van den Toren, E. W., van Gilst, W. H., Wesseling, H., Lie, K. I., Postula, C. T., Hoefnagels, W. B. L., de Boo, Th., Thien, Th., Boon E. S., Goyskes, C. G., Boor, P., van Schalk, B. A. M., Abma, C., Frijns, T. R. J. A., Wamer, J., Elving, L. D., de Nobel, E., Mattie, H., van Gulpen, C., Lammers, J-W. J., Minette, P., Barnes, P. J., Jongejan, R. C., de Jongste, J. C., Raatgeep, H. C., Bonta, I. L., Kerrebijn, K. F., Mol, M. J., Stalenhoef, A. F., Stuyt, P. M., van 't Laar, A., Ermens, A. A. M., Schoester, M., Lindemans, J., Abels, J., van Baak, M. A., Mooij, J. M. V., Schiffers, P. M. H., Wetzels, J. F. M., v. Berqeyk, J. D., v. Heusden, F. H. J. A., Huysmans, F. Th. M., Hoitsma, A. J., Koene, R. A. P., Jansen, H. M. L., Russel, F. G. M., Wouterse, A. C., van Ginneken, C. A. M., Pol, Y. W. A. v. d., de Vries, E. G. E., Greidanus, J., Mulder, N. H., Sleijfer, D. Th., Willemse, P. H. B., Uges, D. R. A., Smits, P. A. B. M., Louwerenburg, J. W., Kingma, J. H., IJdenberg, F. N., Poelma, F. G. J., Breŝ, R., Tukker, J. J., Remmert, H. P., Olling, M., Slob, W., van der Giesen, W., Rauws, A. G., Runhaar, E. A., Neijt, J. P., Holthuis, J. J. M., de Vos, D., Tukker, J J, Poelma, F G J, Thijssen, H. H. W., Hamulyák, K., Franssen, C., Wollersheim, H., Jansen, R. W. M. M., van Lier, H. J. J., Hoefnagels, W. H. L., Grgen, C., Horan, M-A., Oomerjee, Z. A. R., Breimer, D. D., van Bezooijen, C. F. A., Keizer, H. J., Cleton, F. J., de Bruijn, E. A., Tiaden, U. R., de Boer, A., Stiekema, J. C. J., and Danhof, M.

Published
1988
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17. Dementia: Predictors of diagnostic accuracy, and the contribution of diagnostic recommendations

Author

Hein van Hout, Vernooij-Dassen, M. J. F. J., Hoefnagels, W. H. L., Kuin, Y., Stalman, W. A. B., Moons, K. G. M., Grol, R. P. T. M., and VU University medical center

Subjects
Centre for Quality of Care Research, Social Development
Abstract

Item does not contain fulltext OBJECTIVES: To explore and quantify the relative contribution of guideline recommendations and other determinants in the family physicianamprsquos diagnostic work-up of patients suspected of dementia. STUDY DESIGN: We prospectively studied 64 family physicians in an Eastern district in the Netherlands who diagnosed dementia according to the national Dutch guidelines in primary care. Their diagnoses were compared with the reference standard embodied by the memory clinic team of the University Medical Center Nijmegen. POPULATION: The physicians evaluated 107 patients older than 55 years suspected of having dementia. OUTCOMES MEASURED: Predictive values of various clinical and demographic parameters were measured in both univariate and multivariate logistic regression analyses. RESULTS: Activities of daily living (ADL) dependency (odds ratio [OR] = 5.3, P =.03), years since symptoms first started (OR = 1.84, P =.03), and the presence of somatic comorbidity (OR = 0.48, P =.02) independently contributed to the prediction of the presence or absence of dementia. The area under the receiver-operating characteristic (ROC) curve for these 3 variables together was 0.79. The ROC area of the family physiciansamprsquo diagnosis to determine the final diagnosis was 0.74. The number of recommendations applied did not additionally contribute to the assessment of the final diagnosis. CONCLUSIONS: The diagnostic accuracy of the family physician was reasonable. For family physicians, ADL dependency is a better predictor of dementia than cognitive impairment. Family physicians should be aware of diagnostic difficulties in patients with somatic comorbidity. We were unable to confirm the diagnostic value of many of the recommendations of dementia guidelines.

Published
2002

30. Methotrexate maintenance therapy and liver damage in psoriasis.

Author

van de Kerkhof, P. C. M., Hoefnagels, W. H. L., van Haelst, U. J. G. M., and Mali, J. W. H.

Subjects
*BIOPSY, *LIVER, *METHOTREXATE, *PATIENTS, *THERAPEUTICS, *STATISTICS
Abstract

In this communication we report our data on classification of liver biopsies taken from 44 psoriatic patients who had been receiving methotrexate maintenance therapy (Weinstein regime) for long periods. In this series 4.5%. showed cirrhosis and 15.9% fibrosis of the liver. There was no correlation between liver biopsy classification and either the cumulative dose or the duration of methotrexate therapy. A highly significant correlation has been shown between liver damage and the age of the patients. [ABSTRACT FROM AUTHOR]

Published
1985
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32. Evidence for an Unidentified, Adrenocorticotrophic Hormone-Dependent Mineralocorticoid Maintaining Hypertension in Young Women with Hypoaldosteronism

Author

Hoefnagels, W. H. L., Drayer, J. I. M., Hofman, J. A., Smals, A. G. H., Benraad, TH. J., and Kloppenborg, P. W. C.

Abstract

1. Pronounced hypoaldosteronism was found in five young women with low-renin hypertension and characteristic features of the mineralocorticoid hypertensive syndrome. 2. There was no overproduction of the mineralocorticoids 11-deoxycorticosterone and 18-OH-11-deoxycorticosterone. 3. Dexamethasone restored blood pressure to normal, decreased body weight, increased plasma potassium, and increased plasma renin activity and aldosterone excretion in all patients. 4. The data suggest overproduction of an unknown adrenocorticotrophic hormone-dependent mineralocorticoid maintaining hypertension in these patients.

Published
1978
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33. Relative exercise intensity of long-distance marching (120 km in 4 days) in 153 subjects aged 69–87 years

Author

Wild, G. M. de, Peeters, M. P. D., Hoefnagels, W. H. L., Oeseburg, B., and Binkhorst, R. A.

Abstract

The aim of this study was to determine the relative exercise intensity (oxygen uptake during the march/maximal oxygen uptake, V?O 2 march/ V?O 2 max) during a long-distance march in subjects or over 70 years of age. Secondly, the effect of hypertension, cardiovascular and pulmonary diseases on the relative exercise intensity was evaluated. One hundred and fifty-three subjects, 97 men aged 76.7 (4.6) years and 56 women aged 72.8 (3.6) years who completed the 1993 Nijmegen–day long-distance march (30?km?·?day -1 on 4 consecutive days) participated in the study. Oxygen uptake ( V?O 2) during walking at different velocities () was measured in a subgroup of nine men and nine women, selected randomly from the population under study. With these data, regression equations describing the relationship between V?O 2 and were made. V?O 2 march was estimated with the obtained regression equations from an average of the march measured in all participants. V?O 2 max was determined using incremental cycle ergometry in all subjects. V?O 2 march was 13.7 (1.8) ml?·?kg -1 in women at a mean of 5?km?·?h -1 in men and 15.2 (1.3) ml?·?kg?·?min -1 in women at a mean of 5?km?·?h -1 in both sexes. This corresponded to 52% of V?O 2 max in men and 63% in women. In both sexes subjects with cardiovascular and/or pulmonary diseases walked at a slower and thus lower V?O 2 march compared to subjects without these diseases. Due to the lower V?O 2 max in subjects with these diseases there was no difference in the relative exercise intensity between the groups. A multiple linear regression analysis showed that and not age on the prevalence of hypertension, cardiovascular and/or pulmonary that V?O 2 max was the most important predictor of the variance in self-selected march. This study demonstrates that these active people aged over 70 years could maintain a high relative exercise intensity during endurance walking on 4 subsequent days. Furthermore, it shows that the relative exercise intensity of marching is within the range recommended for improving fitness and reducing the risk of cardiovascular diseases. Finally, these results demonstrate that V?O 2 max has a more important influence on performance than does age or chronic diseases in active elderly people.

Published
1997
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34. PITUITARY-THYROID FUNCTION IN SPIRONOLACTONE TREATED HYPERTENSIVE WOMEN

Author

Smals, A. G. H., Kloppenborg, P. W. C., Hoefnagels, W. H. L., and Drayer, J. I. M.

Abstract

Four weeks high dose spironolactone treatment (Aldactone® Searle, 100 mg q. i. d.) significantly enhanced the TSH (Δ max. 8.5 ± 4.1 vs. 4.6 ± 3.1 μU/ml, P< 0.05) and T3(Δ max. 32±27 vs. 11 ± 16 ng/100 ml, P< 0.05) responses to an intravenous TRH/LH-RH bolus injection in 6 eumenorrhoeic euthyroid hypertensive women, without affecting basal serum TSH, T3or T4levels or the basal and stimulated LH, FSH and prolactin values (P> 0.10). The mean serum testosterone, 17-hydroxyprogesterone and oestradiol levels were also similar before and during therapy. Spironolactone, possibly by virtue of its antiandrogenic action, may exert its enhancing effect on pituitary-thyroid function by modulating the levels of receptors for TRH in the thyrotrophs or by altering the T3receptor in the pituitary permitting a greater response to TRH.

Published
1979
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39. Dementia: Predictors of diagnostic accuracy and the contribution of diagnostic recommendations.

Author

Van Hout, H. P. J., Vernooij-Dassen, M. J. F. J., Hoefnagels, W. H. L., Kuin, Y., Stalman, W. A. B., Moons, K. G. M., and Grol, R. P. T. M.

Subjects
*GENERAL practitioners, *DIAGNOSIS, *DEMENTIA, *PRIMARY care, *PATIENTS, *MEDICAL care
Abstract

OBJECTIVES To explore and quantify the relative contribution of guideline recommendations and other determinants in the family physician's diagnostic work-up of patients suspected of dementia. STUDY DESIGN We prospectively studied 64 family physicians in an Eastern district in the Netherlands who diagnosed dementia according to the national Dutch guidelines in primary care. Their diagnoses were compared with the reference standard embodied by the memory clinic team of the University Medical Center Nijmegen. POPULATION The physicians evaluated 107 patients older than 35 years suspected of having dementia. OUTCOMES MEASURED Predictive value of various clinical and demographic parameters were measured in both univariate and multivariate logistic regression analyses. RESULTS Activities of daily living (ADL) dependency (odds ratio [OR] = 5.3, P = .03), years since symptoms first started (OR = 1.84, P = .03), and the presence of somatic comorbidity (OR = 0.48, P = .02) independently contributed to the prediction of the presence or absence of dementia. The area under the receiver-operating characteristic (ROC) curve for these 3 variables together was 0.79. The ROC area of the family physicians' diagnosis to determine the final diagnosis was 0.74. The number of recommendations applied did not additionally contribute to the assessment of the final diagnosis. CONCLUSIONS The diagnostic accuracy of the family physician was reasonable. For family physicians, ADL dependency is a better predictor of dementia than cognitive impairment. Family physicians should be aware of diagnostic difficulties in patients with somatic comorbidity. We were unable to confirm the diagnostic value of many of the recommendations of dementia guidelines. [ABSTRACT FROM AUTHOR]

Published
2002

40. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient.

Author

Janse A, van Iersel M, Hoefnagels WH, and Olde Rikker MG

Subjects
Aged, Aged, 80 and over, Candy, Chronic Disease, Feeding Behavior, Female, Glycyrrhiza chemistry, Humans, Hypokalemia chemically induced, Memory Disorders complications, Pseudohypoaldosteronism chemically induced, Glycyrrhetinic Acid toxicity, Glycyrrhiza toxicity, Hypertension chemically induced
Abstract

The authors report an 85-year-old patient admitted because of cognitive impairment. During examination hypertension and hypokalaemia were found. After some time it was discovered that the patient was eating too much liquorice. The case demonstrates that liquorice intoxication should be considered as a cause of hypertension in old age. Furthermore the case demonstrates that missing an intoxication is a pitfall for medical history taking of patients with cognitive impairment.

Published
2005

41. [Dementia with Lewy bodies; 2 patients with exacerbation due to an atypical antipsychotic, but with a favorable response to the cholinesterase inhibitor rivastigmine].

Author

Scheepmaker AJ, Horstink MW, Hoefnagels WH, and Strijks FE

Subjects
Aged, Aged, 80 and over, Antiparkinson Agents therapeutic use, Antipsychotic Agents adverse effects, Antipsychotic Agents therapeutic use, Benzodiazepines, Drug Therapy, Combination, Humans, Levodopa therapeutic use, Lewy Body Disease psychology, Male, Olanzapine, Pirenzepine adverse effects, Pirenzepine therapeutic use, Risperidone adverse effects, Risperidone therapeutic use, Rivastigmine, Treatment Outcome, Carbamates therapeutic use, Cholinesterase Inhibitors therapeutic use, Lewy Body Disease drug therapy, Neuroprotective Agents therapeutic use, Phenylcarbamates, Pirenzepine analogs & derivatives
Abstract

In two patients, men aged 80 and 75 years with cognitive deterioration, hallucinations and parkinsonism, the clinical diagnosis 'dementia with Lewy bodies' was established. Treatment with an atypical antipsychotic, risperidone and olanzapine respectively, resulted in an exacerbation of the parkinsonism. Rivastigmine evidently improved the psychosis, the anxiety and the cognitive, mood and behaviour disorders. Titrated treatment with levodopa improved the mobility without an increase of the psychosis. The treatment of dementia with Lewy bodies is complex. Levodopa can lead to an increase in visual hallucinations. Antipsychotics often cause serious side effects, such as increasing parkinsonism, sedation and cognitive deterioration. Cholinesterase inhibitors such as rivastigmine could possibly provide an alternative treatment for the neuropsychiatric symptoms.

Published
2003

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