27 results on '"Hoeffe J"'
Search Results
2. Factors associated with parents' willingness to enroll their children in trials for COVID-19 vaccination
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Goldman RD, Staubli G, Parra C, Brown JC, Hoeffe J, Seiler M, Gelernter R, Hall JE, Griffiths MA, Davis AL, Manzano S, Mater A, Ahmed S, Sheridan D, Hansen M, Ali S, Thompson GC, Shimizu N, and Klein EJ
- Subjects
parental attitudes ,decision-making ,Coronavirus ,vaccine trials ,global survey - Abstract
The coronavirus disease 2019 (COVID-19) pandemic has taken an unprecedented global toll and vaccination is needed to restore healthy living. Timely inclusion of children in vaccination trials is critical. We surveyed caregivers of children seeking care in 17 Emergency Departments (ED) across 6 countries during the peak of the pandemic to identify factors associated with intent to participate in COVID-19 vaccine trials. Questions about child and parent characteristics, COVID-19 expressed concerns and parental attitudes toward participation in a trial were asked.Of 2768 completed surveys, 18.4% parents stated they would enroll their child in a clinical trial for a COVID-19 vaccine and 14.4% would agree to a randomized placebo-controlled study. Factors associated with willingness to participate were parents agreeing to enroll in a COVID-19 vaccine trial themselves (Odds Ratio (OR) 32.9, 95% Confidence Interval (CI) (21.9-51.2)) having an older child (OR 1.0 (1.0-1.01)), having children who received all vaccinations based on their country schedule (OR 2.67 (1.35-5.71)) and parents with high school education or lower (OR 1.79 (1.18-2.74)). Mothers were less likely to enroll their child in a trial (OR 0.68 (0.47-0.97)). Only one fifth of families surveyed will consider enrolling their child in a vaccine trial. Parental interest in participation, history of vaccinating their child, and the child being older all are associated with parents allowing their child to participate in a COVID vaccine trial. This information may help decision-makers and researchers shape their strategies for trial design and participation engagement in upcoming COVID19 vaccination trials.
- Published
- 2021
3. Caregiver-reported delay in presentation to pediatric emergency departments for fear of contracting COVID-19: a multi-national cross-sectional study
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Davis AL, Sunderji A, Marneni SR, Seiler M, Hall JE, Parra C, Klein EJ, Brown JC, Gelernter R, Griffiths MA, Hoeffe J, Gualco G, Mater A, Manzano S, Thompson GC, Ahmed S, Ali S, Goldman RD, and International COVID-19 Parental Attitude Study (COVIPAS) Group
- Subjects
Children ,Emergency department ,Caregivers ,Presentation delay ,COVID-19 - Abstract
OBJECTIVE: To determine if caregivers of children presenting to pediatric emergency departments (EDs) during the COVID-19 pandemic are delaying presenting to care for fear of contracting COVID-19. METHODS: This was a pre-planned secondary analysis of a cross-sectional survey study of caregivers accompanying their children aged 0-19 years to 16 pediatric EDs in 5 countries from May to June 2020. An anonymous online survey, completed by caregivers via RedCAP, included caregiver and child demographics, presenting complaints, if they delayed presentation and whether symptoms worsened during this interval, as well as caregiver concern about the child or caregiver having COVID-19 at the time of ED visit. RESULTS: Of 1543 caregivers completing the survey, 287 (18.6%) reported a delay in seeking ED care due to concerns of contracting COVID-19 in the hospital. Of those, 124 (43.2%) stated their child's symptoms worsened during the waiting interval. Caregiver relationship to child [mother] (OR 1.85, 95% CI 1.27-2.76), presence of chronic illness in child (OR 1.78. 95% CI 1.14-2.79), younger age of caregiver (OR 0.965, 95% CI 0.943-0.986), and caregiver concerns about lost work during the pandemic (OR 1.08, 95% CI 1.04-1.12) were independently associated with a COVID-19-related delayed presentation in multivariable regression analysis. CONCLUSIONS: Almost one in five caregivers reported delaying ED presentation for their ill or injured child specifically due to fear of contracting COVID-19 while in hospital, with mothers, younger caregivers, caregivers of children with chronic illness, and those concerned about lost work more likely to report delaying ED presentation.
- Published
- 2021
4. Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
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Goldman RD, Marneni SR, Seiler M, Brown JC, Klein EJ, Parra C, Gelernter R, Yan TD, Hoeffe J, Davis AL, Griffiths MA, Hall JE, Gualco G, Mater A, Manzano S, Thompson GC, Ahmed S, Ali S, Shimizu N, and International COVID-19 Parental Attitude Study (COVIPAS) Group
- Subjects
parental attitudes ,drug approval ,COVID-19 ,vaccine - Abstract
PURPOSE: This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). METHODS: An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine-approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann-Whitney U test for comparing non-normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a ?(2) or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of
- Published
- 2020
5. Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Reserarch Networks (PERN) study.
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Thompson G., Craig S., Babl F., Dalziel S.R., Gray C., Powell C., Al Ansari K., Lyttle M.D., Benito J., Velasco R., Hoeffe J., Moldovan D., Chong S.-L., Graudins A., Kupperman N., Dalziel S., Chamberlain J., Johnson D., Lyttle M., Mintegi S., Mistry R., Nigrovic L., Plint A., Roland D., Van De Van De Voorde P., Schuh S., Zorc J.J., Kwok M., Mahajan P., Johnson M.D., Sapien R., Khanna K., Rino P., Prego J., Yock A., Fernandes R.M., Santhanam I., Cheema B., Ong G., Thompson G., Craig S., Babl F., Dalziel S.R., Gray C., Powell C., Al Ansari K., Lyttle M.D., Benito J., Velasco R., Hoeffe J., Moldovan D., Chong S.-L., Graudins A., Kupperman N., Dalziel S., Chamberlain J., Johnson D., Lyttle M., Mintegi S., Mistry R., Nigrovic L., Plint A., Roland D., Van De Van De Voorde P., Schuh S., Zorc J.J., Kwok M., Mahajan P., Johnson M.D., Sapien R., Khanna K., Rino P., Prego J., Yock A., Fernandes R.M., Santhanam I., Cheema B., and Ong G.
- Abstract
Background: Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation in practice. To improve knowledge in this area, there must first be consensus on how to conduct clinical trials, so that valid comparisons can be made between future studies. We have formed an international working group comprising paediatricians and emergency physicians from North America, Europe, Asia, the Middle East, Africa, South America, Central America, Australasia and the United Kingdom. Methods/design: A 5-stage approach will be used: (1) a comprehensive list of outcomes relevant to stakeholders will be compiled through systematic reviews and qualitative interviews with patients, families, and clinicians; (2) Delphi methodology will be applied to reduce the comprehensive list to a core outcome set; (3) we will review current clinical practice guidelines, existing clinical trials, and literature on bedside assessment of asthma severity. We will then identify practice differences in tne clinical assessment of asthma severity, and determine whether further prospective work is needed to achieve agreement on inclusion criteria for clinical trials in acute paediatric asthma in the emergency department (ED) setting; (4) a retrospective chart review in Australia and New Zealand will identify the incidence of serious clinical complications such as intubation, ICU admission, and death in children hospitalized with acute severe asthma. Understanding the incidence of such outcomes will allow us to understand how common (and therefore how feasible) particular outcomes are in asthma in the ED setting; and finally (5) a meeting of the Pediatric Emergency Research Networks (PERN) asthma working group will be held, with invitation of other clinicians interested in acute asthma research, and patients/families. The group will be a
- Published
- 2020
6. Acute severe paediatric asthma: study protocol for the development of a core outcome set, a Pediatric Emergency Reserarch Networks (PERN) study
- Author
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Craig, S, Babl, FE, Dalziel, SR, Gray, C, Powell, C, Al Ansari, K, Lyttle, MD, Roland, D, Benito, J, Velasco, R, Hoeffe, J, Moldovan, D, Thompson, G, Schuh, S, Zorc, JJ, Kwok, M, Mahajan, P, Johnson, MD, Sapien, R, Khanna, K, Rino, P, Prego, J, Yock, A, Fernandes, RM, Santhanam, I, Cheema, B, Ong, G, Chong, S-L, Graudins, A, Craig, S, Babl, FE, Dalziel, SR, Gray, C, Powell, C, Al Ansari, K, Lyttle, MD, Roland, D, Benito, J, Velasco, R, Hoeffe, J, Moldovan, D, Thompson, G, Schuh, S, Zorc, JJ, Kwok, M, Mahajan, P, Johnson, MD, Sapien, R, Khanna, K, Rino, P, Prego, J, Yock, A, Fernandes, RM, Santhanam, I, Cheema, B, Ong, G, Chong, S-L, and Graudins, A
- Abstract
BACKGROUND: Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation in practice. To improve knowledge in this area, there must first be consensus on how to conduct clinical trials, so that valid comparisons can be made between future studies. We have formed an international working group comprising paediatricians and emergency physicians from North America, Europe, Asia, the Middle East, Africa, South America, Central America, Australasia and the United Kingdom. METHODS/DESIGN: A 5-stage approach will be used: (1) a comprehensive list of outcomes relevant to stakeholders will be compiled through systematic reviews and qualitative interviews with patients, families, and clinicians; (2) Delphi methodology will be applied to reduce the comprehensive list to a core outcome set; (3) we will review current clinical practice guidelines, existing clinical trials, and literature on bedside assessment of asthma severity. We will then identify practice differences in tne clinical assessment of asthma severity, and determine whether further prospective work is needed to achieve agreement on inclusion criteria for clinical trials in acute paediatric asthma in the emergency department (ED) setting; (4) a retrospective chart review in Australia and New Zealand will identify the incidence of serious clinical complications such as intubation, ICU admission, and death in children hospitalized with acute severe asthma. Understanding the incidence of such outcomes will allow us to understand how common (and therefore how feasible) particular outcomes are in asthma in the ED setting; and finally (5) a meeting of the Pediatric Emergency Research Networks (PERN) asthma working group will be held, with invitation of other clinicians interested in acute asthma research, and patients/families. The group will be a
- Published
- 2020
7. Research priorities for European paediatric emergency medicine
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Bressan, S, Titomanlio, L, Gomez, B, Mintegi, S, Gervaix, A, Parri, N, Da Dalt, L, Moll, Henriette, Waisman, Y, Maconochie, IK, Oostenbrink, Rianne, Er, A, Anil, M, Bal, A, Manzano, S, Lacroix, L, Galetto, A, Beattie, T, Bidlingmaier, C, Lucas, N, Maranon, R, Pucuka, Z, Latvia, R, Loellgen, R, Keitel, K, Hoeffe, J, Geurts, Dorien, Dubos, F, Lyttle, M, Bognar, Z, Simon, G, Fodor, L, Romanengo, M, Gras-le-Guen, C, Greber-Platzer, S, Cubells, CL, Teksam, O, Turan, C, Van de Voorde, P, Basmaci, R, Frassanito, A, Saz, U, Irfanos, I, Sotoca, J, Berant, R, Farrugia, R, Velasco, R, Nijman, R, Macao, P, Ege Üniversitesi, and Pediatrics
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medicine.medical_specialty ,Delphi Technique ,Priority list ,Psychological intervention ,Delphi method ,Pediatrics ,Pediatric Emergency Medicine/organization & administration ,Hospital/organization & administration ,Quality Improvement/organization & administration ,1117 Public Health and Health Services ,Europe/epidemiology ,03 medical and health sciences ,0302 clinical medicine ,Paediatric emergency medicine ,030225 pediatrics ,Epidemiology ,medicine ,Medicine and Health Sciences ,Humans ,UK ,Child ,Emergency Service ,Science & Technology ,ddc:618 ,business.industry ,Pediatric Emergency Medicine ,Health Priorities ,Health services research ,030208 emergency & critical care medicine ,1103 Clinical Sciences ,Emergency department ,Quality Improvement ,health services research ,REPEM ,Europe ,epidemiology ,Scale (social sciences) ,Family medicine ,Pediatrics, Perinatology and Child Health ,1114 Paediatrics and Reproductive Medicine ,Original Article ,Health Services Research ,business ,Emergency Service, Hospital ,Life Sciences & Biomedicine - Abstract
Mintegi, Santiago/0000-0002-2342-8881; Gomez, Borja/0000-0001-6542-4494; Nijman, Ruud Gerard/0000-0001-9671-8161; Parri, Niccolo/0000-0002-8098-2504; Maconochie, Ian/0000-0001-6319-8550, WOS: 000495095400013, PubMed: 31023707, Objective Research in European Paediatric Emergency Medicine (REPEM) network is a collaborative group of 69 paediatric emergency medicine (PEM) physicians from 20 countries in Europe, initiated in 2006. To further improve paediatric emergency care in Europe, the aim of this study was to define research priorities for PEM in Europe to guide the development of future research projects. Design and Setting We carried out an online survey in a modified three-stage Delphi study. Eligible participants were members of the REPEM network. in stage 1, the REPEM steering committee prepared a list of research topics. in stage 2, REPEM members rated on a 6-point scale research topics and they could add research topics and comment on the list for further refinement. Stage 3 included further prioritisation using the Hanlon Process of Prioritisation (HPP) to give more emphasis to the feasibility of a research topic. Results Based on 52 respondents (response rates per stage varying from 41% to 57%), we identified the conditions 'fever', 'sepsis' and 'respiratory infections', and the processes/interventions 'biomarkers', 'risk stratification' and 'practice variation' as common themes of research interest. the HPP identified highest priority for 4 of the 5 highest prioritised items by the Delphi process, incorporating prevalence and severity of each condition and feasibility of undertaking such research. Conclusions While the high diversity in emergency department (ED) populations, cultures, healthcare systems and healthcare delivery in European PEM prompts to focus on practice variation of ED conditions, our defined research priority list will help guide further collaborative research efforts within the REPEM network to improve PEM care in Europe.
- Published
- 2019
8. Efficacy and safety of bedtime insulin detemir (IDET) vs. insulin semilente (SEM) in children, adolescents, and young adults with type 1 diabetes (T1D) - a randomised, open-label, cross-over study: 032
- Author
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Kordonouri, O., Datz, N., Hoeffe, J., Marquardt, E., von Schuetz, W., Hartmann, R., Grundner, M., and Danne, T.
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- 2006
9. Research priorities for European paediatric emergency medicine
- Author
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Bressan, S., Titomanlio, L., Gomez, B., Mintegi, S, Gervaix, A, Parri, N, Da Dalt, L, Moll, H.A. (Henriëtte), Waisman, Y, Maconochie, IK, Oostenbrink, R. (Rianne), Er, A., Anil, M., Bal, A., Manzano, S., Lacroix, L, Galetto, A., Beattie, T., Bidlingmaier, C., Lucas, N, Maranon, R., Pucuka, Z., Latvia, R., Loellgen, R., Keitel, K., Hoeffe, J., Geurts, D., Dubos, F., Lyttle, M., Bognar, Z., Simon, G., Fodor, L., Romanengo, M., Gras-le-Guen, C., Greber-Platzer, S., Cubells, C.L., Teksam, O., Turan, C., Voorde, P. (Patrick) van de, Basmaci, R., Frassanito, A., Saz, U., Irfanos, I., Sotoca, J., Berant, R., Farrugia, R., Velasco, R, Nijman, R.M. (Romana), Macao, P., Bressan, S., Titomanlio, L., Gomez, B., Mintegi, S, Gervaix, A, Parri, N, Da Dalt, L, Moll, H.A. (Henriëtte), Waisman, Y, Maconochie, IK, Oostenbrink, R. (Rianne), Er, A., Anil, M., Bal, A., Manzano, S., Lacroix, L, Galetto, A., Beattie, T., Bidlingmaier, C., Lucas, N, Maranon, R., Pucuka, Z., Latvia, R., Loellgen, R., Keitel, K., Hoeffe, J., Geurts, D., Dubos, F., Lyttle, M., Bognar, Z., Simon, G., Fodor, L., Romanengo, M., Gras-le-Guen, C., Greber-Platzer, S., Cubells, C.L., Teksam, O., Turan, C., Voorde, P. (Patrick) van de, Basmaci, R., Frassanito, A., Saz, U., Irfanos, I., Sotoca, J., Berant, R., Farrugia, R., Velasco, R, Nijman, R.M. (Romana), and Macao, P.
- Abstract
Objective Research in European Paediatric Emergency Medicine (REPEM) network is a collaborative group of 69 paediatric emergency medicine (PEM) physicians from 20 countries in Europe, initiated in 2006. To further improve paediatric emergency care in Europe, the aim of this study was to define research priorities for PEM in Europe to guide the development of future research projects. Design and Setting We carried out an online survey in a modified three-stage Delphi study. Eligible participants were members of the REPEM network. In stage 1, the REPEM steering committee prepared a list of research topics. In stage 2, REPEM members rated on a 6-point scale research topics and they could add research topics and comment on the list for further refinement. Stage 3 included further prioritisation using the Hanlon Process of Prioritisation (HPP) to give more emphasis to the feasibility of a research topic. Results Based on 52 respondents (response rates per stage varying from 41% to 57%), we identified the conditions ’fever’, ’sepsis’ and ’respiratory infections’, and the processes/interventions ’biomarkers’, ’risk stratification’ and ’practice variation’ as common themes of research interest. The HPP identified highest priority for 4 of the 5 highest prioritised items by the Delphi process, incorporating prevalence and severity of each condition and feasibility of undertaking such research. Conclusions While the high diversity in emergency department (ED) populations, cultures, healthcare systems and healthcare delivery in European PEM prompts to focus on practice variation of ED conditions, our defined research priority list will help guide further collaborative research efforts within the REPEM network to improve PEM care in Europe.
- Published
- 2019
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10. Results and lessons from continuous glucose monitoring in a large cohort of children with type-1 diabetes: OP 005
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Deiss, D., Hartmann, R., Hoeffe, J., and Kordonouri, O.
- Published
- 2004
11. Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: The FAN observational study
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Hoeffe, J., primary, Doyon Trottier, E., additional, Bailey, B., additional, Shellshear, D., additional, Lagacé, M., additional, Sutter, C., additional, Grimard, G., additional, Cook, R., additional, and Babl, F.E., additional
- Published
- 2017
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12. The Fan Study: Intranasal Fentanyl and Inhaled Nitrous Oxide for Fracture Reduction
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Hoeffe, J, primary, Trottier, ED, additional, Bailey, B, additional, Shellshear, D, additional, Lagacé, M, additional, Sutter, C, additional, Grimard, G, additional, Cook, R, additional, and Babl, FE, additional
- Published
- 2016
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13. P030: The FAN study: intranasal fentanyl and inhaled nitrous oxide for fracture reduction
- Author
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Hoeffe, J., primary, Trottier, E. D., additional, Bailey, B., additional, Shellshear, D., additional, Lagacé, M., additional, Sutter, C., additional, Grimard, G., additional, Cook, R., additional, and Babl, F., additional
- Published
- 2016
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14. 158: Present and Future of Emergency Point-of-Care Ultrasound in Pediatric Emergency Fellowship Programs in Canada
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Hoeffe, J, primary, Desjardins, MP, additional, Fischer, J, additional, Carrière, B, additional, and Gravel, J, additional
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- 2015
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15. New methods in assessing clinical reasoning: the script concordance test
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Hoeffe, J, Sostmann, K, Guthmann, F, Knigge, M, and Gaedicke, G
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
[for full text, please go to the a.m. URL], Research in Medical Education - Chances and Challenges 2009
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- 2009
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16. Development of a script concordance test for undergraduate education in pediatrics
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Hoeffe, J, Gaedicke, G, Knigge, M, Krude, H, Müller, S, and Sostmann, K
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ddc: 610 - Published
- 2007
17. Entwicklung eines Skript-Konkordanz-Testes für die pädiatrische Ausbildung
- Author
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Hoeffe, J, Gaedicke, G, Knigge, M, Krude, H, Müller, S, Sostmann, K, Hoeffe, J, Gaedicke, G, Knigge, M, Krude, H, Müller, S, and Sostmann, K
- Published
- 2007
18. Ergebnisse einer randomisierten, multizentrischen Studie zur Behandlung mit Insulindetemir (DET) und Semilente MC (SEM) bei Kindern, Jugendlichen und jungen Erwachsenen mit Typ 1 Diabetes (T1D)
- Author
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Kordonouri, O, primary, Datz, N, additional, Hoeffe, J, additional, Marquardt, E, additional, Hartmann, R, additional, von Schütz, W, additional, Grundner, M, additional, and Danne, T, additional
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- 2006
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19. Assessment of glycemic control by continuous glucose monitoring system in 50 children with type 1 diabetes starting on insulin pump therapy.
- Author
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Deiss D, Hartmann R, Hoeffe J, and Kordonouri O
- Abstract
OBJECTIVE: To report experience with a continuous glucose monitoring system (CGMS) and to identify factors influencing glycemic control in a large cohort of children and adolescents with type 1 diabetes and change to insulin pump therapy via continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN and METHODS: In 50 patients [21 boys, 29 girls; median age 12.6 yr (range: 1.3-16.4 yr); diabetes duration 5.0 yr (0.2-13.3)], hemoglobin A1c (HbA1c) and ambulatory CGMS were performed before and 6 wk after starting CSII. Average glucose concentration per 24 h, during day and night time as well as number of excursions, duration, and area under the curve (AUC) of glucose values above 180 mg/dL and below 60 mg/dL were calculated from CGMS data. Simultaneously, metabolic control was documented by standardized self-monitoring of blood glucose (SMBG). RESULTS: In the total cohort, HbA1c improved from 8.1 +/- 1.2% at baseline to 7.7 +/- 0.9% after 6 wk of CSII (p <0.001). This effect was more distinct in boys (8.0 +/- 1.4 vs. 7.5 +/- 1.1%, p=0.007) than in girls (8.1 +/- 1.1 vs. 7.8 +/- 0.7%, p=0.039) as well as in patients with poor glycemic control (HbA1c >8.0%) at baseline (8.9 +/- 0.6 vs. 8.1 +/- 0.8%, p <0.001) and in those older than 12 yr (8.2 +/- 1.2 vs. 7.7 +/- 1.0%, p <0.001). At 6 wk of CSII, the values of glucose average per 24 h, AUC and time above 180 mg/dL, particularly during the day, improved. HbA1c was correlated with AUC above 180 mg/dL (r=0.742, p <0.001) and CGMS average glucose per 24 h (r=0.628, p=0.002), but to a lesser extent with SMBG values (r=0.418, p=0.054). CONCLUSION: With the change to CSII, HbA1c improved significantly after 6 wk of therapy. CGMS usage provided additional information about glycemic control in these patients. [ABSTRACT FROM AUTHOR]
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- 2004
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20. Age-specific advantages of continuous subcutaneous insulin infusion as compared with multiple daily injections in pediatric patients: one-year follow-up comparison by matched-pair analysis.
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Kordonouri O, Hartmann R, Lauterborn R, Barnekow C, Hoeffe J, Deiss D, Kordonouri, Olga, Hartmann, Reinhard, Lauterborn, Renate, Barnekow, Christine, Hoeffe, Julia, and Deiss, Dorothee
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- 2006
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21. Pediatric Sedation and Analgesia Outside the Operating Room: Combining Intranasal Fentanyl and Inhaled Nitrous Oxide.
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Hoeffe J, Vogel RG, and Ammann RA
- Abstract
Objective: Combining intranasal fentanyl (IN FENT) with inhaled nitrous oxide (N
2 O) seems to have good properties for pediatric procedural sedation and analgesia (PSA). This study aims to assess the side effect rate of the combined use of IN FENT and N2 O., Methods: We performed a retrospective, single-center study. Patients treated in either the pediatric emergency department (PED) or the pediatric surgery outpatient clinic (PSOC) were included, if they received PSA with IN FENT and nitrous oxide with 50% oxygen (N2 O 50%)., Results: Three hundred seventy-five patients were included over a period of 4 years. Median age was 9.4 years (range, 3.1 to 15.9) and 39% of patients were female. Overall side effect rate was 30% (114 patients). Most frequent was dizziness (n = 63, 17%; 95% CI, 13-21), followed by nausea (n = 23, 6%; 95% CI, 4-9) and emesis (n = 14, 4%; 95% CI, 2-6), with 35 patients having either nausea and/or emesis (9%; 95% CI, 7-13). No serious side effects were recorded (0%; 95% CI, 0-0.1). Of 298 patients with information regarding satisfaction, 280 patients would like the same sedation for a similar procedure in the future (94%; 95% CI, 90-96). We found no relation between previously described risk factors and emesis and/or nausea., Conclusions: N2 O 50% combined with IN FENT can be recommended as an effective and safe treatment in the PED and the PSOC. While the side effect rate, primarily dizziness, nausea and emesis was substantial, antiemetic prophylaxis is not indicated owing to the overall low incidence of nausea and emesis., Competing Interests: Disclosures. The authors report no conflict of interest. Supported by a grant from the Stiftung Batzebaer of the University Children's Hospital, Bern, Switzerland, and the Notfallzentrum fuer Kinder und Jugendliche, University Hospital, Bern, Switzerland., (Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email: membership@pediatricpharmacy.org 2022.)- Published
- 2022
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22. A tale of two parts of Switzerland: regional differences in the impact of the COVID-19 pandemic on parents.
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Seiler M, Staubli G, Hoeffe J, Gualco G, Manzano S, and Goldman RD
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- Child, Europe, Humans, Parents, SARS-CoV-2, Switzerland epidemiology, COVID-19, Pandemics
- Abstract
Background: We aimed to document the impact of the coronavirus disease 2019 (COVID-19) pandemic on regions within a European country., Methods: Parents arriving at two pediatric emergency departments (EDs) in North of Switzerland and two in South of Switzerland completed an online survey during the first peak of the pandemic (April-June 2020). They were asked to rate their concern about their children or themselves having COVID-19., Results: A total of 662 respondents completed the survey. Parents in the South were significantly more exposed to someone tested positive for COVID-19 than in the North (13.9 and 4.7%, respectively; P < 0.001). Parents in the South were much more concerned than in the North that they (mean 4.61 and 3.32, respectively; P < 0.001) or their child (mean 4.79 and 3.17, respectively; P < 0.001) had COVID-19. Parents reported their children wore facemasks significantly more often in the South than in the North (71.5 and 23.5%, respectively; P < 0.001)., Conclusion: The COVID-19 pandemic resulted in significant regional differences among families arriving at EDs in Switzerland. Public health agencies should consider regional strategies, rather than country-wide guidelines, in future pandemics and for vaccination against COVID-19 for children.
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- 2021
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23. Parents' intent to vaccinate against influenza during the COVID-19 pandemic im two regions in Switzerland.
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Seiler M, Goldman RD, Staubli G, Hoeffe J, Gualco G, and Manzano S
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- COVID-19 Vaccines, Child, Communicable Disease Control, Health Knowledge, Attitudes, Practice, Humans, Intention, Pandemics prevention & control, Parents, SARS-CoV-2, Switzerland epidemiology, Vaccination, COVID-19 prevention & control, Influenza Vaccines, Influenza, Human epidemiology, Influenza, Human prevention & control
- Abstract
Aims of the Study: The COVID-19 pandemic is likely to overlap with the seasonal influenza epidemic, increasing the risk of overextending the health system capacity in Switzerland. Influenza vaccine uptake has remained low in most countries, including Switzerland. The aim of the study was to determine parents' intentions towards influenza vaccination of their children as well as themselves, and to assess regional differences., Methods: Parents presenting to four pediatric emergency departments (PEDs; Zurich, Bern, Bellinzona, Geneva) were asked to complete an online survey during and after the first lockdown of the COVID-19 pandemic (April - June 2020). The anonymized survey included demographic information, vaccination history and intentions to vaccinate against influenza, as well as attitudes towards future vaccination against COVID-19., Results: The majority of children (92%; 602/654) were up-to-date on their vaccination schedule. In 2019/2020, 7.2% (47/654) were vaccinated against influenza. Children with chronic illnesses were more frequently vaccinated compared to healthy children (19.2% vs 5.6%; p = 0.002). For the coming winter season, 111 (17%) parents stated they plan to vaccinate their children against influenza, more than double the rate from last year, and 383 (59.2%) parents suggest they will vaccinate against COVID-19 once a vaccine is available. Regional differences between "German" and "Latin" Switzerland were found for parents' intent to have their children vaccinated against influenza next season (Zurich and Bern 14.3%, Bellinzona and Geneva 27.2%, p < 0.001) but not for a hypothetical vaccination against COVID-19 (Zurich and Bern 59.1%, Bellinzona and Geneva 59.7%, p = 0.894)., Conclusions: The COVID-19 pandemic resulted in a substantial increase of parents' intention to vaccinating their children against influenza, especially in hard-hit "Latin" Switzerland. The Swiss government and public health organizations can leverage these regional results to promote influenza vaccination among children for the coming seasons.
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- 2021
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24. Willingness to Vaccinate Children against Influenza after the Coronavirus Disease 2019 Pandemic.
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Goldman RD, McGregor S, Marneni SR, Katsuta T, Griffiths MA, Hall JE, Seiler M, Klein EJ, Cotanda CP, Gelernter R, Hoeffe J, Davis AL, Gualco G, Mater A, Manzano S, Thompson GC, Ahmed S, Ali S, and Brown JC
- Subjects
- Adolescent, Caregivers, Child, Child, Preschool, Decision Making, Emergency Service, Hospital, Female, Health Knowledge, Attitudes, Practice, Humans, Immunization Programs, Infant, Infant, Newborn, International Cooperation, Male, Parents, Public Health, Risk, Surveys and Questionnaires, Young Adult, COVID-19 epidemiology, Influenza Vaccines therapeutic use, Influenza, Human prevention & control, Vaccination
- Abstract
Objectives: To determine factors associated with parents who plan to vaccinate their children against influenza next year, especially those who did not vaccinate against influenza last year using a global survey., Study Design: A survey of caregivers accompanying their children aged 1-19 years old in 17 pediatric emergency departments in 6 countries at the peak of the coronavirus disease 2019 (COVID-19) pandemic. Anonymous online survey included caregiver and child demographic information, vaccination history and future intentions, and concern about the child and caregiver having COVID-19 at the time of emergency department visit., Results: Of 2422 surveys, 1314 (54.2%) caregivers stated they plan to vaccinate their child against influenza next year, an increase of 15.8% from the previous year. Of 1459 caregivers who did not vaccinate their children last year, 418 (28.6%) plan to do so next year. Factors predicting willingness to change and vaccinate included child's up-to-date vaccination status (aOR 2.03, 95% CI 1.29-3.32, P = .003); caregivers' influenza vaccine history (aOR 3.26, 95% CI 2.41-4.40, P < .010), and level of concern their child had COVID-19 (aOR 1.09, 95% CI 1.01-1.17, P = .022)., Conclusions: Changes in risk perception due to COVID-19, and previous vaccination, may serve to influence decision-making among caregivers regarding influenza vaccination in the coming season. To promote influenza vaccination among children, public health programs can leverage this information., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2021
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25. Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey.
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Goldman RD, Yan TD, Seiler M, Parra Cotanda C, Brown JC, Klein EJ, Hoeffe J, Gelernter R, Hall JE, Davis AL, Griffiths MA, Mater A, Manzano S, Gualco G, Shimizu N, Hurt TL, Ahmed S, Hansen M, Sheridan D, Ali S, Thompson GC, Gaucher N, and Staubli G
- Subjects
- Adult, Betacoronavirus immunology, COVID-19, COVID-19 Vaccines, Child, Coronavirus Infections economics, Coronavirus Infections epidemiology, Coronavirus Infections immunology, Coronavirus Infections virology, Cross-Sectional Studies, Emergency Service, Hospital, Europe epidemiology, Female, Humans, Immunity, Herd, International Cooperation, Israel epidemiology, Japan epidemiology, Male, Multivariate Analysis, North America epidemiology, Pneumonia, Viral epidemiology, Pneumonia, Viral immunology, Pneumonia, Viral virology, SARS-CoV-2, Vaccination Coverage statistics & numerical data, Vaccination Refusal statistics & numerical data, Viral Vaccines biosynthesis, Betacoronavirus pathogenicity, Coronavirus Infections prevention & control, Pandemics prevention & control, Pneumonia, Viral prevention & control, Vaccination psychology, Vaccination Refusal psychology, Viral Vaccines economics
- Abstract
Background: More than 100 COVID-19 vaccine candidates are in development since the SARS-CoV-2 genetic sequence was published in January 2020. The uptake of a COVID-19 vaccine among children will be instrumental in limiting the spread of the disease as herd immunity may require vaccine coverage of up to 80% of the population. Prior history of pandemic vaccine coverage was as low as 40% among children in the United States during the 2009 H1N1 influenza pandemic., Purpose: To investigate predictors associated with global caregivers' intent to vaccinate their children against COVID-19, when the vaccine becomes available., Method: An international cross sectional survey of 1541 caregivers arriving with their children to 16 pediatric Emergency Departments (ED) across six countries from March 26 to May 31, 2020., Results: 65% (n = 1005) of caregivers reported that they intend to vaccinate their child against COVID-19, once a vaccine is available. A univariate and subsequent multivariate analysis found that increased intended uptake was associated with children that were older, children with no chronic illness, when fathers completed the survey, children up-to-date on their vaccination schedule, recent history of vaccination against influenza, and caregivers concerned their child had COVID-19 at the time of survey completion in the ED. The most common reason reported by caregivers intending to vaccinate was to protect their child (62%), and the most common reason reported by caregivers refusing vaccination was the vaccine's novelty (52%)., Conclusions: The majority of caregivers intend to vaccinate their children against COVID-19, though uptake will likely be associated with specific factors such as child and caregiver demographics and vaccination history. Public health strategies need to address barriers to uptake by providing evidence about an upcoming COVID-19 vaccine's safety and efficacy, highlighting the risks and consequences of infection in children, and educating caregivers on the role of vaccination., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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- 2020
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26. Acute severe paediatric asthma: study protocol for the development of a core outcome set, a Pediatric Emergency Reserarch Networks (PERN) study.
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Craig S, Babl FE, Dalziel SR, Gray C, Powell C, Al Ansari K, Lyttle MD, Roland D, Benito J, Velasco R, Hoeffe J, Moldovan D, Thompson G, Schuh S, Zorc JJ, Kwok M, Mahajan P, Johnson MD, Sapien R, Khanna K, Rino P, Prego J, Yock A, Fernandes RM, Santhanam I, Cheema B, Ong G, Chong SL, and Graudins A
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- Acute Disease, Age Factors, Asthma diagnosis, Asthma mortality, Asthma physiopathology, Consensus, Delphi Technique, Humans, Interviews as Topic, Qualitative Research, Risk Assessment, Risk Factors, Severity of Illness Index, Stakeholder Participation, Systematic Reviews as Topic, Treatment Outcome, Asthma therapy, Endpoint Determination standards, Lung physiopathology, Outcome and Process Assessment, Health Care standards, Randomized Controlled Trials as Topic standards, Research Design
- Abstract
Background: Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation in practice. To improve knowledge in this area, there must first be consensus on how to conduct clinical trials, so that valid comparisons can be made between future studies. We have formed an international working group comprising paediatricians and emergency physicians from North America, Europe, Asia, the Middle East, Africa, South America, Central America, Australasia and the United Kingdom., Methods/design: A 5-stage approach will be used: (1) a comprehensive list of outcomes relevant to stakeholders will be compiled through systematic reviews and qualitative interviews with patients, families, and clinicians; (2) Delphi methodology will be applied to reduce the comprehensive list to a core outcome set; (3) we will review current clinical practice guidelines, existing clinical trials, and literature on bedside assessment of asthma severity. We will then identify practice differences in tne clinical assessment of asthma severity, and determine whether further prospective work is needed to achieve agreement on inclusion criteria for clinical trials in acute paediatric asthma in the emergency department (ED) setting; (4) a retrospective chart review in Australia and New Zealand will identify the incidence of serious clinical complications such as intubation, ICU admission, and death in children hospitalized with acute severe asthma. Understanding the incidence of such outcomes will allow us to understand how common (and therefore how feasible) particular outcomes are in asthma in the ED setting; and finally (5) a meeting of the Pediatric Emergency Research Networks (PERN) asthma working group will be held, with invitation of other clinicians interested in acute asthma research, and patients/families. The group will be asked to achieve consensus on a core set of outcomes and to make recommendations for the conduct of clinical trials in acute severe asthma. If this is not possible, the group will agree on a series of prioritized steps to achieve this aim., Discussion: The development of an international consensus on core outcomes is an important first step towards the development of consensus guidelines and standardised protocols for randomized controlled trials (RCTs) in this population. This will enable us to better interpret and compare future studies, reduce risks of study heterogeneity and outcome reporting bias, and improve the evidence base for the management of this important condition.
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- 2020
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27. Emergency point-of-care ultrasound in Canadian pediatric emergency fellowship programs: current integration and future directions.
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Hoeffe J, Desjardins MP, Fischer J, Carriere B, and Gravel J
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- Adult, Canada, Cross-Sectional Studies, Emergency Service, Hospital, Female, Forecasting, Humans, Internship and Residency organization & administration, Male, Pediatrics, Program Development, Program Evaluation, Clinical Competence, Emergency Medicine education, Fellowships and Scholarships organization & administration, Point-of-Care Systems organization & administration, Surveys and Questionnaires, Ultrasonography methods
- Abstract
Background: Adult and pediatric emergency physicians have been using point-of-care ultrasound (POCUS) for many years. It is a fast, usually painless, noninvasive diagnostic tool that does not expose the patient to radiation. Information about its current implementation in pediatric emergency medicine (PEM) fellowship programs in Canada is lacking., Objective: The main goal of our study was to investigate current integration and future direction of POCUS training in Canadian PEM programs., Methods: The study consisted of two surveys designed for fellows and program directors of all Canadian PEM fellowship programs. The major aspects of the survey were 1) to describe current training in POCUS in fellowship programs, 2) to compare the kind of training that programs offer with what fellows actually receive, and 3) a needs assessment by fellows and program directors for future POCUS training programs. Surveys were sent to program directors and passed on to their fellows., Results: Ninety percent of fellowship program directors as well as 70% (42/60) of fellows responded to the survey. A formal POCUS curriculum exists in five of the nine PEM programs included in this study. Three programs offer specific pediatric POCUS training. The main application is the FAST (focused assessment with sonography for trauma) exam., Conclusion: There is a wide variation in POCUS content and delivery across PEM fellowship programs, as well as differences in perceptions of current training and of needs by fellows and program directors. However, given that both groups feel POCUS is very important and essential for PEM training, the opportunity exists to develop a standardized curriculum across Canada.
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- 2016
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