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251 results on '"Hodosy, Július"'

7. Mitochondrial DNA variability and Covid-19 in the Slovak population

Author

Bľandová, Gabriela, primary, Janoštiaková, Nikola, additional, Kodada, Dominik, additional, Pastorek, Michal, additional, Lipták, Róbert, additional, Hodosy, Július, additional, Šebeková, Katarína, additional, Celec, Peter, additional, Krasňanská, Gabriela, additional, Eliaš, Vladimír, additional, Wachsmannová, Lenka, additional, Konečný, Michal, additional, Repiská, Vanda, additional, and Baldovič, Marian, additional

Published
2023
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11. Sex Steroid Hormones in Depressive Disorders as a Basis for New Potential Treatment Strategies

Author

PILLEROVÁ, Miriam, PASTOREK, Michal, BORBÉLYOVÁ, Veronika, RILJAK, Vladimír, FRICK, Karyn M., HODOSY, Július, and TÓTHOVÁ, Ľubomíra

Subjects
Physiology, Review, General Medicine
Abstract

The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metabolites have important organizational and activational impacts on the brain during critical periods of brain development and in adulthood. A variety of slow and rapid mechanisms mediate both organizational and activational processes via intracellular or membrane receptors for SSHs. Physiological concentrations and distribution of SSHs in the brain result in normal brain development. Nevertheless, dysregulation of hormonal equilibrium may result in several mood disorders, including depressive disorders, later in adolescence or adulthood. Gender differences in cognitive abilities, emotions as well as the 2-3 times higher prevalence of depressive disorders in females, were already described. This implies that SSHs may play a role in the development of depressive disorders. In this review, we discuss preclinical and clinical studies linked to SSHs and development of depressive disorders. Our secondary aim includes a review of up-to-date knowledge about molecular mechanisms in the pathogenesis of depressive disorders. Understanding these molecular mechanisms might lead to significant treatment adjustments for patients with depressive disorders and to an amelioration of clinical outcomes for these patients. Nevertheless, the impact of SSHs on the brain in the context of the development of depressive disorders, progression, and treatment responsiveness is complex in nature, and depends upon several factors in concert such as gender, age, comorbidities, and general health conditions.

Published
2022

12. Mitochondria-induced formation of neutrophil extracellular traps is enhanced in the elderly via Toll-like receptor 9

Author

Pastorek, Michal, primary, Konečná, Barbora, additional, Janko, Jakub, additional, Janovičová, Ľubica, additional, Podracká, Ľudmila, additional, Záhumenský, Jozef, additional, Šteňová, Emöke, additional, Dúbrava, Martin, additional, Hodosy, Július, additional, Vlková, Barbora, additional, and Celec, Peter, additional

Published
2023
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26. Contributors

Author

Altaf, Q.A., primary, Angelico, Francesco, additional, Ayala, Enrique Calvo, additional, Banks, Siobhan, additional, Baratta, Francesco, additional, Baron, Kelly G., additional, Bonsignore, Maria Rosaria, additional, Calhoun, Susan L., additional, Castaño-Meneses, Violeta Alejandra, additional, Castrogiovanni, Alessandra, additional, Celec, Peter, additional, Chen, Maida Lynn, additional, Coates, Alison, additional, Corgosinho, Flávia C., additional, Cui, Renzhe, additional, Dâmaso, Ana R., additional, Danese, Alessandra, additional, Del Ben, Maria, additional, Dorrian, Jillian, additional, Dreher, Alfred, additional, Eisenberg, Dan, additional, Fernandez-Mendoza, Julio, additional, Garaulet, Marta, additional, García-Ramos, Guillermo, additional, Gómez-Abellán, Purificación, additional, Grant, Crystal, additional, Grassi, Guido, additional, A. Grogan, Wendell, additional, Gruttad’Auria, Claudia Irene, additional, Güneş, Zeynep, additional, Hairston, Ilana S., additional, Hakim, Fahed, additional, Hammoud, Ahmad O., additional, Häring, Hans-Ulrich, additional, Harris, Shelby, additional, Hasan, Ashfaq, additional, Heath, Georgina, additional, Hodosy, Július, additional, Hofman, Winni F., additional, Howe, Heather E., additional, Igelström, Helena, additional, Inoue, Yuichi, additional, Iso, Hiroyasu, additional, Kaul, Ashutosh, additional, Kenney, Shannon R., additional, Killgore, William D.S., additional, Komada, Yoko, additional, Kumar, B. Santhosh, additional, Linford, Nancy, additional, Macedo, António, additional, Maffei, Anthony, additional, Marik, Paul E., additional, Marotta, Anna Maria, additional, Marrone, Oreste, additional, Matsuoka, Nobuhide, additional, Mazzuca, Emilia, additional, de Mello, Marco T., additional, Mokhlesi, Babak, additional, Mucska, Imrich, additional, Mugnai, Giacomo, additional, Nielsen, Forrest H., additional, Olson, Heather Carmichael, additional, Pastori, Daniele, additional, Patel, Amee A., additional, Piper, Amanda J., additional, Polimeni, Licia, additional, Reid, Kathryn J., additional, Resendiz-Garcia, Montserrat, additional, Rolls, Asya, additional, Ruby, Christina L., additional, Santiago-Ayala, Victoria, additional, Sartorius, Tina, additional, Seravalle, Gino, additional, Sharafkhaneh, Hossein, additional, Soares, Maria João, additional, St-Onge, Marie-Pierre, additional, Sundar, Krishna M., additional, Tahrani, Abd A., additional, Talamini, Lucia M., additional, Tamura, Akira, additional, Thorpy, Michael, additional, Uzma, Nazia, additional, Valencia-Flores, Matilde, additional, Walters, Arthur S., additional, and Weinstock, Leonard B., additional

Published
2015
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45. Sex Difference in Plasma Deoxyribonuclease Activity in Rats.

Author

JANOVIČOVÁ, Ľubica, GROMOVÁ, Barbora, DROBNÁ, Diana, KONEČNÁ, Barbora, RENCZÉS, Emese, BORBÉLYOVÁ, Veronika, HODOSY, Július, and CELEC, Peter

Subjects
LABORATORY rats, NUCLEAR DNA, RATS, DEOXYRIBONUCLEASES, CELL-free DNA
Abstract

Extracellular DNA (ecDNA) activates immune cells and is involved in the pathogenesis of diseases associated with inflammation such as sepsis, rheumatoid arthritis or metabolic syndrome. DNA can be cleaved by deoxyribonucleases (DNases), some of which are secreted out of cells. The aim of this experiment was to describe plasma DNase activity in relation to extracellular DNA in adult rats, to analyse potential sex differences and to prove whether they are related to endogenous testosterone. Adult Lewis rats (n=28) of both sexes were included in the experiment. Male rats were gonadectomized or sham-operated and compared to intact female rats. Plasma ecDNA and DNase activity were measured using fluorometry and single radial enzyme diffusion assay, respectively. Concentrations of nuclear ecDNA and mitochondrial ecDNA were determined using real-time PCR. Females had 60% higher plasma DNase activity than males (p=0.03). Gonadectomy did not affect plasma DNase aktivity in males. Neither the concentration of total ecDNA, nor nuclear or mitochondrial DNA in plasma differed between the groups. No significant correlations between DNase aktivity and ecDNA were found. From previous studies on mice, it was expected, that male rats will have higher DNase activity. In contrast, our study in rats showed the opposite sex difference. This sex difference seems not to be caused by endogenous testosterone. Interestingly, no sex differences were observed in plasma ecDNA suggesting a complex or missing association between plasma ecDNA and DNase. The observed sex difference in plasma DNase aktivity should be taken into account in animal models of ecDNAassociated diseases. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Acute Effect of Cola and Caffeine on Locomotor Activity in Drosophila and Rat.

Author

KMEŤOVÁ, Katarína, MARÔNEK, Martin, BORBÉLYOVÁ, Veronika, HODOSY, Július, and CELEC, Peter

Subjects
RATS, COST-of-living adjustments, COLA drinks, CAFFEINE, DROSOPHILA, CARBONATED beverages, SOFT drinks
Abstract

Caffeine is well known for reducing fatigue and its effect on behavior is widely studied. Usually, caffeine is not ingested in its pure form but rather in sugar-sweetened beverages such as cola. Our aim was to compare the acute effect of cola and caffeine on locomotor activity. Rats and flies ingested cola or caffeine solution for 24 hours. The open field test revealed higher locomotor activity in cola groups for both flies and rats. Surprisingly, no differences have been observed between caffeine and control group. We conclude that caffeine itself does not explain the effect of cola on locomotor activity. Effect of cola cannot be generalized and interpreted for any caffeinated drink with other contents. Rather, the observed effect on locomotor activity may be caused by interaction of caffeine with other substances present in cola. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Testosterone and the Brain: From Cognition to Autism.

Author

OSTATNÍKOVÁ, Daniela, LAKATOŠOVÁ, Silvia, BABKOVÁ, Jaroslava, HODOSY, Július, and CELEC, Peter

Subjects
GENDER, SEXUAL dimorphism, AUTISTIC children, AUTISM spectrum disorders, SEX chromosomes, AUTISM
Abstract

Sex and gender matter in all aspects of life. Humans exhibit sexual dimorphism in anatomy, physiology, but also pathology. Many of the differences are due to sex chromosomes and, thus, genetics, other due to endocrine factors such as sex hormones, some are of social origin. Over the past decades, huge number of scientific studies have revealed striking sex differences of the human brain with remarkable behavioral and cognitive consequences. Prenatal and postnatal testosterone influence brain structures and functions, respectively. Cognitive sex differences include especially certain spatial and language tasks, but they also affect many other aspects of the neurotypical brain. Sex differences of the brain are also relevant for the pathogenesis of neuropsychiatric disorders such as autism spectrum disorders, which are much more prevalent in the male population. Structural dimorphism in the human brain was welldescribed, but recent controversies now question its importance. On the other hand, solid evidence exists regarding gender differences in several brain functions. This review tries to summarize the current understanding of the complexity of the effects of testosterone on brain with special focus on their role in the known sex differences in healthy individuals and people in the autism spectrum. [ABSTRACT FROM AUTHOR]

Published
2020
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