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227 results on '"Hodis, H."'

2. Menopausal hormone therapy and coronary heart disease: the roller-coaster history.

Author

Nudy, M., Buerger, J., Dreibelbis, S., Jiang, X., Hodis, H. N., and Schnatz, P. F.

Subjects
CORONARY disease, HORMONE therapy, PREMATURE menopause, POSTMENOPAUSE, WOMEN'S health, SLEEP interruptions
Abstract

In the USA it is estimated that more than one million women become menopausal each year. Coronary heart disease (CHD) is the leading cause of mortality in menopausal woman globally. The majority of perimenopausal to postmenopausal women experience bothersome symptoms including hot flashes, night sweats, mood liability, sleep disturbances, irregular bleeding and sexual dysfunction. While menopausal hormone therapy (HT) effectively treats most of these symptoms, use of HT has become confusing, especially related to CHD risk. Despite years of observational and retrospective studies supporting a CHD benefit and improved survival among HT users, the Heart and Estrogen/Progestin Replacement Study (HERS) and the Women's Health Initiative (WHI) raised doubts about this long-held premise. The timing hypothesis has since emerged and states that when HT is initiated in younger women, soon after menopause onset, there may be cardiovascular benefit. The following review discusses the roller-coaster history of HT use as it pertains to CHD in postmenopausal women. Studies that highlight HT's CHD benefit are reviewed and provide reassurance that HT utilized in appropriately selected younger postmenopausal women close to the onset of menopause is safe from a cardiovascular perspective, in line with consensus recommendations. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Oxidative Damage to Circulating LDL

Author

Cazzolato, G., Kramsch, D. M., Sevanian, A., Hodis, H., Bittolo Bon, G., Avogaro, P., Catapano, A. L., editor, Gotto, A. M., Jr., editor, Smith, Louis C., editor, and Paoletti, Rodolfo, editor

Published
1993
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16. Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy.

Author

Sriprasert, I., Hodis, H. N., Bernick, B., Mirkin, S., and Mack, W. J.

Subjects
*PROGESTERONE, *ESTRADIOL, *POSTMENOPAUSE, *ALCOHOL drinking, *HORMONE therapy
Abstract

Among postmenopausal women taking hormone therapy (HT), the estradiol (E2) dose and E2 levels were differentially associated with change in metabolic measures. We evaluated determinants of attained E2 levels in response to HT. Postmenopausal women from the REPLENISH trial tested four formulations of oral combined E2 and progesterone compared with placebo. Mixed-effects linear models assessed characteristics associated with E2 levels among women with ≥80% HT compliance, adjusted for E2 dose and baseline E2 level. Among 1173 postmenopausal women with mean (standard deviation) age 55 (4.3) years and 5.2 (4.8) years since menopause, higher treated E2 levels were significantly related to younger age, more recent menopause, and current alcohol use, while lower E2 levels were related to current smoking. Both age and time since menopause were significantly inversely associated with E2 levels; time since menopause had a stronger association with E2 levels. In the final multivariable model, E2 levels were positively associated with current alcohol use, and inversely associated with time since menopause and current smoking. Adjusting for E2 dose and baseline E2 level, on-trial E2 levels were significantly associated with time since menopause, current smoking, and current alcohol use. Practitioners should consider these factors in individual women to achieve a desirable E2 level during HT. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Prevention of diseases after menopause

Author

Lobo, R A, Davis, S R, de Villiers, T J, Gompel, A, Henderson, V W, Hodis, H N, Lumsden, M A, Mack, W J, Shapiro, S, Baber, R J, Department of Public Health and Family Medicine, and Faculty of Health Sciences

Subjects
Risk, Homo sapiens, Longevity, Coronary Disease, Estrogens, Therapeutics, Risk Assessment, PREVENTION, Hormones, CARDIOVASCULAR, Diet, Cardiovascular Diseases, Neoplasms, Alcohols, Osteoarthritis, Chronic Disease, Osteoporosis, COGNITION, Dementia, Obesity, Menopause, Mortality, Exercise, Follow-Up Studies
Abstract

Women may expect to spend more than a third of their lives after menopause. Beginning in the sixth decade, many chronic diseases will begin to emerge, which will affect both the quality and quantity of a woman's life. Thus, the onset of menopause heralds an opportunity for prevention strategies to improve the quality of life and enhance longevity. Obesity, metabolic syndrome and diabetes, cardiovascular disease, osteoporosis and osteoarthritis, cognitive decline, dementia and depression, and cancer are the major diseases of concern. Prevention strategies at menopause have to begin with screening and careful assessment for risk factors, which should also include molecular and genetic diagnostics, as these become available. Identification of certain risks will then allow directed therapy. Evidence-based prevention for the diseases noted above include lifestyle management, cessation of smoking, curtailing excessive alcohol consumption, a healthy diet and moderate exercise, as well as mentally stimula...

Published
2014
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22. Prevention of diseases after menopause

Author

Lobo, R. A., primary, Davis, S. R., additional, De Villiers, T. J., additional, Gompel, A., additional, Henderson, V. W., additional, Hodis, H. N., additional, Lumsden, M. A., additional, Mack, W. J., additional, Shapiro, S., additional, and Baber, R. J., additional

Published
2014
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