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534 results on '"Hodgson, David C."'

6. Single gene mutations and prognosis in limited‐stage follicular lymphoma treated with radiation therapy.

Author

Hershenfeld, Samantha A., Tobin, Josuha W.D., Shelton, Victoria, Calvente, Lourdes, Lajkosz, Katherine, Liu, Ting, Brodtkorb, Marianne, d'Amore, Francesco Annibale, Ludvigsen, Maja, Baetz, Tara, LeBrun, David, Johnson, Nathalie, Crump, Michael, Hong, Michael, Kuruvilla, John, Tremblay‐LeMay, Rosemarie, MacManus, Michael, Tsang, Richard, Hodgson, David C., and Gandhi, Maher K.

Subjects
FOLLICULAR lymphoma, FALSE discovery rate, GENETIC mutation, PROGNOSIS, DISEASE relapse
Abstract

Summary: Radiotherapy is routinely used for management of limited‐stage follicular lymphoma (FL), yet half of patients ultimately relapse. We hypothesized that the presence of specific gene mutations may predict outcomes. We performed targeted sequencing of a 69‐gene panel in 117 limited‐stage FL patients treated with radiotherapy and identified recurrently mutated genes. CREBBP was most frequently mutated, and mutated CREBBP was associated with inferior progression‐free survival, though not after false discovery rate adjustment. This association failed to validate in an independent cohort. We conclude that recurrent gene mutations do not predict outcomes in this setting. Alternative biomarkers may offer better prognostic insight. [ABSTRACT FROM AUTHOR]

Published
2024
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9. A Prospective Study of Machine Learning–Assisted Radiation Therapy Planning for Patients Receiving 54 Gy to the Brain

Author

Tsang, Derek S., primary, Tsui, Grace, additional, Santiago, Anna T., additional, Keller, Harald, additional, Purdie, Thomas, additional, Mcintosh, Chris, additional, Bauman, Glenn, additional, La Macchia, Nancy, additional, Parent, Amy, additional, Dama, Hitesh, additional, Ahmed, Sameera, additional, Laperriere, Normand, additional, Millar, Barbara-Ann, additional, Liu, Valerie, additional, and Hodgson, David C., additional

Published
2024
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10. Late Cardiac Toxic Effects Associated With Treatment Protocols for Hodgkin Lymphoma in Children

Author

Lo, Andrea C., primary, Liu, Amy, additional, Liu, Qi, additional, Yasui, Yutaka, additional, Castellino, Sharon M., additional, Kelly, Kara M., additional, Hererra, Alex F., additional, Friedberg, Jonathan W., additional, Friedman, Debra L., additional, Schwartz, Cindy L., additional, Pei, Qinglin, additional, Kessel, Sandy, additional, Bergeron-Gravel, Samuel, additional, Dama, Hitesh, additional, Roberts, Kenneth, additional, Constine, Louis S., additional, and Hodgson, David C., additional

Published
2024
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11. Definitive radiotherapy for localized follicular lymphoma staged by 18F-FDG PET-CT: a collaborative study by ILROG

Author

Brady, Jessica L., Binkley, Michael S., Hajj, Carla, Chelius, Monica, Chau, Karen, Balogh, Alex, Levis, Mario, Filippi, Andrea Riccardo, Jones, Michael, Mac Manus, Michael, Wirth, Andrew, Oguchi, Masahiko, Vistisen, Anders Krog, Andraos, Therese Youssef, Ng, Andrea K., Aleman, Berthe M.P., Choi, Seo Hee, Kirova, Youlia, Hardy, Sara, Reinartz, Gabriele, Eich, Hans T., Bratman, Scott V., Constine, Louis S., Suh, Chang-Ok, Dabaja, Bouthaina, El-Galaly, Tarec C., Hodgson, David C., Ricardi, Umberto, Yahalom, Joachim, Hoppe, Richard T., and Mikhaeel, N. George

Published
2019
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12. Improving the drivability of electric vehicles using advanced control and estimation

Author

Hodgson, David C.

Subjects
629.22
Abstract

The mechanical drivetrain dynamics of electric vehicles can have a detrimental effect on the driving experience and performance of the vehicle. Factors such as large gear backlashes, low damped axles and the relatively low inertia and friction of electric motors can lead to a drivetrain that is prone to oscillation and therefore giving a non-smooth acceleration response. When this is combined with unknown driving conditions, such as low traction surfaces and significant changes in the vehicle’s mass, this can cause the vehicle’s drivability to be poor, especially when closed loop speed control is required. Generally for all industrial vehicles and many on-road vehicles the only feedback to the vehicle motor controller is from the encoder on the motor, as it is already required for the flux vector control of induction and permanent magnet AC motors. Although the motor speed can easily be converted into a vehicle speed after taking into account gear ratios and tyre radius, it is not valid to assume that the motor and vehicle speeds are proportionally equal during transient conditions where there can be significant differences between them due to flexibility in the drivetrain. Electric vehicles offer improved efficiency over internal combustion engine (ICE) vehicles which can then be enhanced further through regenerative braking. Although this can lead to undesirable and dangerous conditions such as loss of traction during braking due to excessive regenerative braking, especially if the vehicle is rear wheel drive. Without any additional feedbacks it is traditionally assumed to be difficult to detect loss of traction or maximise the energy recovered through regenerative braking without risking wheel lock up. It has been shown that vehicle drivability can be greatly improved if estimates of vehicle speed and mass are obtained. Using a fixed gain Kalman Filter (KF) for state estimation and a Recursive Least Squares (RLS) scheme for parameter estimation, both vehicle speed and mass have been estimated and used to improve the closed loop speed performance. The estimated values are also used for preventing loss of tyre traction with the road surface. Additionally a scheme for reducing oscillations without estimating vehicle speed for use in torque control mode applications is developed. The Kalman Filter only works effectively when the correct process noise matrix Q and measurement noise matrix R are used, as well as the model being a reasonably accurate representation of the real system. Optimal tuning has been carried out using Genetic Algorithms (GA), with the estimation accuracy then analysed for robustness to varying vehicle mass. Gearbox backlash is the most significant issue within the drivetrain, as it is often the initial cause of the oscillations during torque reversals; allowing the motor speed to accelerate much faster than that of the vehicle during the disconnect. A scheme that can reduce the delay when traversing the backlash during torque reversals but also decrease the impact speed to virtually zero has been created.

Published
2014

14. A User's Guide and Summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation Dose-Volume Response for Adverse Effects After Childhood Cancer Therapy and Future Directions

Author

Constine, Louis S., primary, Marks, Lawrence B., additional, Milano, Michael T., additional, Ronckers, Cécile M., additional, Jackson, Andrew, additional, Hudson, Melissa M., additional, Marcus, Karen J., additional, Hodgson, David C., additional, Hua, Chia-Ho, additional, Howell, Rebecca M., additional, Marples, Brian, additional, Yorke, Ellen, additional, Olch, Arthur, additional, and Bentzen, Soren M., additional

Published
2023
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15. A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk

Author

Koh, Eng-Siew, Tran, Tu Huan, Heydarian, Mostafa, Sachs, Rainer K, Tsang, Richard W, Brenner, David J, Pintilie, Melania, Xu, Tony, Chung, June, Paul, Narinder, and Hodgson, David C

Subjects
Lung, Cancer, Cardiovascular, Heart Disease, Rare Diseases, Lymphoma, Hematology, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Female, Hodgkin Disease, Humans, Lung Neoplasms, Male, Mediastinum, Medical Oncology, Middle Aged, Neoplasm Metastasis, Neoplasms, Second Primary, Radiometry, Radiotherapy, Risk, Treatment Outcome, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundHodgkin's lymphoma (HL) survivors who undergo radiotherapy experience increased risks of second cancers (SC) and cardiac sequelae. To reduce such risks, extended-field radiotherapy (RT) for HL has largely been replaced by involved field radiotherapy (IFRT). While it has generally been assumed that IFRT will reduce SC risks, there are few data that quantify the reduction in dose to normal tissues associated with modern RT practice for patients with mediastinal HL, and no estimates of the expected reduction in SC risk.MethodsOrgan-specific dose-volume histograms (DVH) were generated for 41 patients receiving 35 Gy mantle RT, 35 Gy IFRT, or 20 Gy IFRT, and integrated organ mean doses were compared for the three protocols. Organ-specific SC risk estimates were estimated using a dosimetric risk-modeling approach, analyzing DVH data with quantitative, mechanistic models of radiation-induced cancer.ResultsDose reductions resulted in corresponding reductions in predicted excess relative risks (ERR) for SC induction. Moving from 35 Gy mantle RT to 35 Gy IFRT reduces predicted ERR for female breast and lung cancer by approximately 65%, and for male lung cancer by approximately 35%; moving from 35 Gy IFRT to 20 Gy IFRT reduces predicted ERRs approximately 40% more. The median reduction in integral dose to the whole heart with the transition to 35 Gy IFRT was 35%, with a smaller (2%) reduction in dose to proximal coronary arteries. There was no significant reduction in thyroid dose.ConclusionThe significant decreases estimated for radiation-induced SC risks associated with modern IFRT provide strong support for the use of IFRT to reduce the late effects of treatment. The approach employed here can provide new insight into the risks associated with contemporary IFRT for HL, and may facilitate the counseling of patients regarding the risks associated with this treatment.

Published
2007

19. Stomach Cancer Following Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer: A Pooled Analysis of Three International Studies with a Focus on Radiation Effects

Author

Gilbert, Ethel S., Curtis, Rochelle E., Hauptmann, Michael, Kleinerman, Ruth A., Lynch, Charles F., Stovall, Marilyn, Smith, Susan A., Weathers, Rita, Andersson, Michael, Dores, Graça M., Fraumeni,, Joseph F., Fossa, Sophie D., Hall, Per, Hodgson, David C., Holowaty, Eric J., Joensuu, Heikki, Johannesen, Tom B., Langmark, Froydis, Kaijser, Magnus, Pukkala, Eero, Rajaraman, Preetha, Storm, Hans H., Vaalavirta, Leila, van den Belt-Dusebout, Alexandra W., Aleman, Berthe M., Travis, Lois B., Morton, Lindsay M., and van Leeuwen, Flora E.

Published
2017

21. Development and Validation of Risk Prediction Models for Coronary Heart Disease and Heart Failure After Treatment for Hodgkin Lymphoma

Author

MS Hematologie, Regenerative Medicine and Stem Cells, Cancer, de Vries, Simone, Haaksma, Miriam L, Jóźwiak, Katarzyna, Schaapveld, Michael, Hodgson, David C, Lugtenburg, Pieternella J, Krol, Augustinus D G, Petersen, Eefke J, van Spronsen, Dick Johan, Ahmed, Sameera, Hauptmann, Michael, Aleman, Berthe M P, van Leeuwen, Flora E, MS Hematologie, Regenerative Medicine and Stem Cells, Cancer, de Vries, Simone, Haaksma, Miriam L, Jóźwiak, Katarzyna, Schaapveld, Michael, Hodgson, David C, Lugtenburg, Pieternella J, Krol, Augustinus D G, Petersen, Eefke J, van Spronsen, Dick Johan, Ahmed, Sameera, Hauptmann, Michael, Aleman, Berthe M P, and van Leeuwen, Flora E

Published
2023

22. Prognostic value of chest x‐ray‐ and CT‐defined large mediastinal adenopathy in high‐risk pediatric Hodgkin lymphoma: A report from the Children's Oncology Group Study AHOD0831

Author

Lo, Andrea C., primary, Lee, Inki, additional, Pei, Qinglin, additional, Wu, Yue, additional, McCarten, Kathleen M., additional, Hoppe, Bradford S., additional, Hodgson, David C., additional, Roberts, Kenneth, additional, Milgrom, Sarah, additional, Kessel, Sandy, additional, Cole, Peter D., additional, Kelly, Kara M., additional, and Cho, Steve Y., additional

Published
2023
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23. Radiotherapy Use in Refractory and Relapsed Adolescent and Young Adult Hodgkin Lymphoma: A Report from the Children's Oncology Group

Author

Vega, Raymond B. Mailhot, primary, Harker-Murray, Paul D., additional, Forlenza, Christopher J., additional, Cole, Peter, additional, Kelly, Kara M., additional, Milgrom, Sarah A., additional, Parikh, Rahul R., additional, Hodgson, David C., additional, Castellino, Sharon M., additional, Kahn, Justine, additional, Roberts, Kenneth B., additional, Constine, Louis S., additional, and Hoppe, Bradford S., additional

Published
2023
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24. Importance of Central Imaging Review in a Pediatric Hodgkin Lymphoma Trial Using PET Response−Adapted Radiotherapy

Author

Hoppe, Bradford S., primary, McCarten, Kathleen M., additional, Pei, Qinglin, additional, Kessel, Sandy, additional, Alazraki, Adina, additional, Mhlanga, Joyce C., additional, Lai, Hollie A., additional, Eutsler, Eric, additional, Hodgson, David C., additional, Roberts, Kenneth B., additional, Charpentier, Anne-Marie, additional, Keller, Frank G., additional, Voss, Stephan D., additional, Wu, Yue, additional, Cho, Steve Y., additional, Kelly, Kara M., additional, and Castellino, Sharon M., additional

Published
2023
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31. Development and Validation of Risk Prediction Models for Coronary Heart Disease and Heart Failure After Treatment for Hodgkin Lymphoma

Author

de Vries, Simone, primary, Haaksma, Miriam L., additional, Jóźwiak, Katarzyna, additional, Schaapveld, Michael, additional, Hodgson, David C., additional, Lugtenburg, Pieternella J., additional, Krol, Augustinus D.G., additional, Petersen, Eefke J., additional, van Spronsen, Dick Johan, additional, Ahmed, Sameera, additional, Hauptmann, Michael, additional, Aleman, Berthe M.P., additional, and van Leeuwen, Flora E., additional

Published
2023
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32. ACR Appropriateness Criteria Follow-up of Hodgkin Lymphoma

Author

Ha, Chul S., Hodgson, David C., Advani, Ranjana, Dabaja, Bouthaina S., Dhakal, Sughosh, Flowers, Christopher R., Hoppe, Bradford S., Mendenhall, Nancy P., Metzger, Monika L., Plastaras, John P., Roberts, Kenneth B., Shapiro, Ronald, Smith, Sonali, Terezakis, Stephanie A., Winkfield, Karen M., Younes, Anas, and Constine, Louis S.

Published
2014
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37. Development and Validation of the advanced-Stage Hodgkin Lymphoma (HL) International Prognostication Index (A-HIPI): A Report from the Hodgkin Lymphoma International Study for Individual Care (HoLISTIC) Consortium

Author

Rodday, Angie Mae, primary, Parsons, Susan K., additional, Friedberg, Jonathan W., additional, Gallamini, Andrea, additional, Hawkes, Eliza, additional, Hodgson, David C., additional, Johnson, Peter, additional, Link, Brian K., additional, Mou, Eric, additional, Savage, Kerry J., additional, Upshaw, Jenica, additional, Zinzani, Pier Luigi, additional, Maurer, Matthew J., additional, and Evens, Andrew M., additional

Published
2022
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41. Brentuximab vedotin and association with event-free survival (EFS) in children with newly diagnosed high-risk Hodgkin lymphoma (HL): A report from the Children's Oncology Group phase 3 study AHOD1331 (NCT 02166463).

Author

Castellino, Sharon M., primary, Pei, Qinglin, additional, Parsons, Susan K., additional, Hodgson, David C., additional, McCarten, Kathleen, additional, Punnett, Angela, additional, Horton, Terzah M., additional, Dave, Hema Kishore, additional, Cho, Steve Y., additional, Wu, Yue, additional, Henderson, Tara O., additional, Hoppe, Bradford, additional, Keller, Frank G., additional, and Kelly, Kara, additional

Published
2022
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44. Patterns of Initial Relapse from a Phase 3 Study of Response-Based Therapy for High-Risk Hodgkin Lymphoma (AHOD0831): A Report from the Children's Oncology Group

Author

Parikh, Rahul R., primary, Kelly, Kara M., additional, Hodgson, David C., additional, Hoppe, Bradford S., additional, McCarten, Kathleen M., additional, Karolczuk, Katie, additional, Pei, Qinglin, additional, Wu, Yue, additional, Cho, Steve Y., additional, Schwartz, Cindy, additional, Cole, Peter D., additional, and Roberts, Kenneth, additional

Published
2022
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47. Malignant lymphomas

Author

Kroschinsky, Frank, primary, Stölzel, Friedrich, additional, Pileri, Stefano A., additional, Chapuy, Björn, additional, Ordemann, Rainer, additional, Gisselbrecht, Christian, additional, Illidge, Tim, additional, Hodgson, David C., additional, Gospodarowicz, Mary K., additional, Schütze, Christina, additional, and Wulf, Gerald, additional

Published
2016
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