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1. VHE gamma-ray detection of FSRQ QSO B1420+326 and modeling of its enhanced broadband state in 2020

Author

Acciari, V. A. (V. A.), Ansoldi, S. (S.), Antonelli, L. A. (L. A.), Engels, A. A. (A. Arbet), Artero, M. (M.), Asano, K. (K.), Baack, D. (D.), Babic, A. (A.), Baquero, A. (A.), de Almeida, U. B. (U. Barres), Barrio, J. A. (J. A.), Becerra Gonzalez, J. (J.), Bednarek, W. (W.), Bellizzi, L. (L.), Bernardini, E. (E.), Bernardos, M. (M.), Berti, A. (A.), Besenrieder, J. (J.), Bhattacharyya, W. (W.), Bigongiari, C. (C.), Biland, A. (A.), Blanch, O. (O.), Bonnoli, G. (G.), Bosnjak, Z. (Z.), Busetto, G. (G.), Carosi, R. (R.), Ceribella, G. (G.), Cerruti, M. (M.), Chai, Y. (Y.), Chilingarian, A. (A.), Cikota, S. (S.), Colak, S. M. (S. M.), Colombo, E. (E.), Contreras, J. L. (J. L.), Cortina, J. (J.), Covino, S. (S.), D'Amico, G. (G.), D'Elia, V. (V.), Da Vela, P. (P.), Dazzi, F. (F.), De Angelis, A. (A.), De Lotto, B. (B.), Delfino, M. (M.), Delgado, J. (J.), Delgado Mendez, C. (C.), Depaoli, D. (D.), Di Pierro, F. (F.), Di Venere, L. (L.), Do Souto Espineira, E. (E.), Prester, D. D. (D. Dominis), Donini, A. (A.), Dorner, D. (D.), Doro, M. (M.), Elsaesser, D. (D.), Ramazani, V. F. (V. Fallah), Fattorini, A. (A.), Ferrara, G. (G.), Foffano, L. (L.), Fonseca, M. V. (M. V.), Font, L. (L.), Fruck, C. (C.), Fukami, S. (S.), Garcia Lopez, R. J. (R. J.), Garczarczyk, M. (M.), Gasparyan, S. (S.), Gaug, M. (M.), Giglietto, N. (N.), Giordano, F. (F.), Gliwny, P. (P.), Godinovic, N. (N.), Green, J. G. (J. G.), Green, D. (D.), Hadasch, D. (D.), Hahn, A. (A.), Heckmann, L. (L.), Herrera, J. (J.), Hoang, J. (J.), Hrupec, D. (D.), Hutten, M. (M.), Inada, T. (T.), Inoue, S. (S.), Ishio, K. (K.), Iwamura, Y. (Y.), Jormanainen, J. (J.), Jouvin, L. (L.), Kajiwara, Y. (Y.), Karjalainen, M. (M.), Kerszberg, D. (D.), Kobayashi, Y. (Y.), Kubo, H. (H.), Kushida, J. (J.), Lamastra, A. (A.), Lelas, D. (D.), Leone, F. (F.), Lindfors, E. (E.), Lombardi, S. (S.), Longo, F. (F.), Lopez-Coto, R. (R.), Lopez-Moya, M. (M.), Lopez-Oramas, A. (A.), Loporchio, S. (S.), Fraga, B. M. (B. Machado de Oliveira), Maggio, C. (C.), Majumdar, P. (P.), Makariev, M. (M.), Mallamaci, M. (M.), Maneva, G. (G.), Manganaro, M. (M.), Mannheim, K. (K.), Maraschi, L. (L.), Mariotti, M. (M.), Martinez, M. (M.), Mazin, D. (D.), Mender, S. (S.), Micanovic, S. (S.), Miceli, D. (D.), Miener, T. (T.), Minev, M. (M.), Miranda, J. M. (J. M.), Mirzoyan, R. (R.), Molina, E. (E.), Moralejo, A. (A.), Morcuende, D. (D.), Moreno, V. (V.), Moretti, E. (E.), Neustroev, V. (V.), Nigro, C. (C.), Nilsson, K. (K.), Ninci, D. (D.), Nishijima, K. (K.), Noda, K. (K.), Nozaki, S. (S.), Ohtani, Y. (Y.), Oka, T. (T.), Otero-Santos, J. (J.), Paiano, S. (S.), Palatiello, M. (M.), Paneque, D. (D.), Paoletti, R. (R.), Paredes, J. M. (J. M.), Pavletic, L. (L.), Penil, P. (P.), Perennes, C. (C.), Persic, M. (M.), Moroni, P. G. (P. G. Prada), Prandini, E. (E.), Priyadarshi, C. (C.), Puljak, I. (I.), Rhode, W. (W.), Ribo, M. (M.), Rico, J. (J.), Righi, C. (C.), Rugliancich, A. (A.), Saha, L. (L.), Sahakyan, N. (N.), Saito, T. (T.), Sakurai, S. (S.), Satalecka, K. (K.), Saturni, F. G. (F. G.), Schleicher, B. (B.), Schmidt, K. (K.), Schweizer, T. (T.), Sitarek, J. (J.), Snidaric, I. (I.), Sobczynska, D. (D.), Spolon, A. (A.), Stamerra, A. (A.), Strom, D. (D.), Strzys, M. (M.), Suda, Y. (Y.), Suric, T. (T.), Takahashi, M. (M.), Tavecchio, F. (F.), Temnikov, P. (P.), Terzic, T. (T.), Teshima, M. (M.), Torres-Alba, N. (N.), Tosti, L. (L.), Truzzi, S. (S.), Tutone, A. (A.), van Scherpenberg, J. (J.), Vanzo, G. (G.), Vazquez Acosta, M. (M.), Ventura, S. (S.), Verguilov, V. (V.), Vigorito, C. F. (C. F.), Vitale, V. (V.), Vovk, I. (I.), Will, M. (M.), Zaric, D. (D.), Angioni, R. (R.), D'Ammando, F. (F.), Ciprini, S. (S.), Cheung, C. C. (C. C.), Orienti, M. (M.), Pacciani, L. (L.), Prajapati, P. (P.), Kumar, P. (P.), Ganesh, S. (S.), Kurtenkov, A. (A.), Marchini, A. (A.), Carrasco, L. (L.), Escobedo, G. (G.), Porras, A. (A.), Recillas, E. (E.), Lahteenmaki, A. (A.), Tornikoski, M. (M.), Berton, M. (M.), Tammi, J. (J.), Vera, R. J. (R. J. C.), Jorstad, S. G. (S. G.), Marscher, A. P. (A. P.), Weaver, Z. R. (Z. R.), Hart, M. (M.), Hallum, M. K. (M. K.), Larionov, V. M. (V. M.), Borman, G. A. (G. A.), Grishina, T. S. (T. S.), Kopatskaya, E. N. (E. N.), Larionova, E. G. (E. G.), Nikiforova, A. A. (A. A.), Morozova, D. A. (D. A.), Savchenko, S. S. (S. S.), Troitskaya, Y. V. (Yu. V.), Troitsky, I. S. (I. S.), Vasilyev, A. A. (A. A.), Hodges, M. (M.), Hovatta, T. (T.), Kiehlmann, S. (S.), Max-Moerbeck, W. (W.), Readhead, A. C. (A. C. S.), Reeves, R. (R.), Pearson, T. J. (T. J.), Acciari, V. A. (V. A.), Ansoldi, S. (S.), Antonelli, L. A. (L. A.), Engels, A. A. (A. Arbet), Artero, M. (M.), Asano, K. (K.), Baack, D. (D.), Babic, A. (A.), Baquero, A. (A.), de Almeida, U. B. (U. Barres), Barrio, J. A. (J. A.), Becerra Gonzalez, J. (J.), Bednarek, W. (W.), Bellizzi, L. (L.), Bernardini, E. (E.), Bernardos, M. (M.), Berti, A. (A.), Besenrieder, J. (J.), Bhattacharyya, W. (W.), Bigongiari, C. (C.), Biland, A. (A.), Blanch, O. (O.), Bonnoli, G. (G.), Bosnjak, Z. (Z.), Busetto, G. (G.), Carosi, R. (R.), Ceribella, G. (G.), Cerruti, M. (M.), Chai, Y. (Y.), Chilingarian, A. (A.), Cikota, S. (S.), Colak, S. M. (S. M.), Colombo, E. (E.), Contreras, J. L. (J. L.), Cortina, J. (J.), Covino, S. (S.), D'Amico, G. (G.), D'Elia, V. (V.), Da Vela, P. (P.), Dazzi, F. (F.), De Angelis, A. (A.), De Lotto, B. (B.), Delfino, M. (M.), Delgado, J. (J.), Delgado Mendez, C. (C.), Depaoli, D. (D.), Di Pierro, F. (F.), Di Venere, L. (L.), Do Souto Espineira, E. (E.), Prester, D. D. (D. Dominis), Donini, A. (A.), Dorner, D. (D.), Doro, M. (M.), Elsaesser, D. (D.), Ramazani, V. F. (V. Fallah), Fattorini, A. (A.), Ferrara, G. (G.), Foffano, L. (L.), Fonseca, M. V. (M. V.), Font, L. (L.), Fruck, C. (C.), Fukami, S. (S.), Garcia Lopez, R. J. (R. J.), Garczarczyk, M. (M.), Gasparyan, S. (S.), Gaug, M. (M.), Giglietto, N. (N.), Giordano, F. (F.), Gliwny, P. (P.), Godinovic, N. (N.), Green, J. G. (J. G.), Green, D. (D.), Hadasch, D. (D.), Hahn, A. (A.), Heckmann, L. (L.), Herrera, J. (J.), Hoang, J. (J.), Hrupec, D. (D.), Hutten, M. (M.), Inada, T. (T.), Inoue, S. (S.), Ishio, K. (K.), Iwamura, Y. (Y.), Jormanainen, J. (J.), Jouvin, L. (L.), Kajiwara, Y. (Y.), Karjalainen, M. (M.), Kerszberg, D. (D.), Kobayashi, Y. (Y.), Kubo, H. (H.), Kushida, J. (J.), Lamastra, A. (A.), Lelas, D. (D.), Leone, F. (F.), Lindfors, E. (E.), Lombardi, S. (S.), Longo, F. (F.), Lopez-Coto, R. (R.), Lopez-Moya, M. (M.), Lopez-Oramas, A. (A.), Loporchio, S. (S.), Fraga, B. M. (B. Machado de Oliveira), Maggio, C. (C.), Majumdar, P. (P.), Makariev, M. (M.), Mallamaci, M. (M.), Maneva, G. (G.), Manganaro, M. (M.), Mannheim, K. (K.), Maraschi, L. (L.), Mariotti, M. (M.), Martinez, M. (M.), Mazin, D. (D.), Mender, S. (S.), Micanovic, S. (S.), Miceli, D. (D.), Miener, T. (T.), Minev, M. (M.), Miranda, J. M. (J. M.), Mirzoyan, R. (R.), Molina, E. (E.), Moralejo, A. (A.), Morcuende, D. (D.), Moreno, V. (V.), Moretti, E. (E.), Neustroev, V. (V.), Nigro, C. (C.), Nilsson, K. (K.), Ninci, D. (D.), Nishijima, K. (K.), Noda, K. (K.), Nozaki, S. (S.), Ohtani, Y. (Y.), Oka, T. (T.), Otero-Santos, J. (J.), Paiano, S. (S.), Palatiello, M. (M.), Paneque, D. (D.), Paoletti, R. (R.), Paredes, J. M. (J. M.), Pavletic, L. (L.), Penil, P. (P.), Perennes, C. (C.), Persic, M. (M.), Moroni, P. G. (P. G. Prada), Prandini, E. (E.), Priyadarshi, C. (C.), Puljak, I. (I.), Rhode, W. (W.), Ribo, M. (M.), Rico, J. (J.), Righi, C. (C.), Rugliancich, A. (A.), Saha, L. (L.), Sahakyan, N. (N.), Saito, T. (T.), Sakurai, S. (S.), Satalecka, K. (K.), Saturni, F. G. (F. G.), Schleicher, B. (B.), Schmidt, K. (K.), Schweizer, T. (T.), Sitarek, J. (J.), Snidaric, I. (I.), Sobczynska, D. (D.), Spolon, A. (A.), Stamerra, A. (A.), Strom, D. (D.), Strzys, M. (M.), Suda, Y. (Y.), Suric, T. (T.), Takahashi, M. (M.), Tavecchio, F. (F.), Temnikov, P. (P.), Terzic, T. (T.), Teshima, M. (M.), Torres-Alba, N. (N.), Tosti, L. (L.), Truzzi, S. (S.), Tutone, A. (A.), van Scherpenberg, J. (J.), Vanzo, G. (G.), Vazquez Acosta, M. (M.), Ventura, S. (S.), Verguilov, V. (V.), Vigorito, C. F. (C. F.), Vitale, V. (V.), Vovk, I. (I.), Will, M. (M.), Zaric, D. (D.), Angioni, R. (R.), D'Ammando, F. (F.), Ciprini, S. (S.), Cheung, C. C. (C. C.), Orienti, M. (M.), Pacciani, L. (L.), Prajapati, P. (P.), Kumar, P. (P.), Ganesh, S. (S.), Kurtenkov, A. (A.), Marchini, A. (A.), Carrasco, L. (L.), Escobedo, G. (G.), Porras, A. (A.), Recillas, E. (E.), Lahteenmaki, A. (A.), Tornikoski, M. (M.), Berton, M. (M.), Tammi, J. (J.), Vera, R. J. (R. J. C.), Jorstad, S. G. (S. G.), Marscher, A. P. (A. P.), Weaver, Z. R. (Z. R.), Hart, M. (M.), Hallum, M. K. (M. K.), Larionov, V. M. (V. M.), Borman, G. A. (G. A.), Grishina, T. S. (T. S.), Kopatskaya, E. N. (E. N.), Larionova, E. G. (E. G.), Nikiforova, A. A. (A. A.), Morozova, D. A. (D. A.), Savchenko, S. S. (S. S.), Troitskaya, Y. V. (Yu. V.), Troitsky, I. S. (I. S.), Vasilyev, A. A. (A. A.), Hodges, M. (M.), Hovatta, T. (T.), Kiehlmann, S. (S.), Max-Moerbeck, W. (W.), Readhead, A. C. (A. C. S.), Reeves, R. (R.), and Pearson, T. J. (T. J.)

Abstract

Context.: QSO B1420+326 is a blazar classified as a flat-spectrum radio quasar (FSRQ). At the beginning of the year 2020, it was found to be in an enhanced flux state and an extensive multiwavelength campaign allowed us to trace the evolution of the flare. Aims.: We search for very high-energy (VHE) gamma-ray emission from QSO B1420+326 during this flaring state. We aim to characterize and model the broadband emission of the source over different phases of the flare. Methods: The source was observed with a number of instruments in radio, near-infrared, optical (including polarimetry and spectroscopy), ultraviolet, X-ray, and gamma-ray bands. We use dedicated optical spectroscopy results to estimate the accretion disk and the dust torus luminosity. We performed spectral energy distribution modeling in the framework of combined synchrotron-self-Compton and external Compton scenario in which the electron energy distribution is partially determined from acceleration and cooling processes. Results: During the enhanced state, the flux of both SED components of QSO B1420+326 drastically increased and the peaks were shifted to higher energies. Follow-up observations with the MAGIC telescopes led to the detection of VHE gamma-ray emission from this source, making it one of only a handful of FSRQs known in this energy range. Modeling allows us to constrain the evolution of the magnetic field and electron energy distribution in the emission region. The gamma-ray flare was accompanied by a rotation of the optical polarization vector during a low -polarization state. Also, a new superluminal radio knot contemporaneously appeared in the radio image of the jet. The optical spectroscopy shows a prominent FeII bump with flux evolving together with the continuum emission and a MgII line with varying equivalent width.

Published
2021

2. Testing two-component models on very high-energy gamma-ray-emitting BL Lac objects

Author

Acciari, V. A. (V. A.), Ansoldi, S. (S.), Antonelli, L. A. (L. A.), Engels, A. A. (A. Arbet), Baack, D. (D.), Babic, A. (A.), Banerjee, B. (B.), de Almeida, U. B. (U. Barres), Barrio, J. A. (J. A.), Gonzalez, J. B. (J. Becerra), Bednarek, W. (W.), Bellizzi, L. (L.), Bernardini, E. (E.), Berti, A. (A.), Besenrieder, J. (J.), Bhattacharyya, W. (W.), Bigongiari, C. (C.), Biland, A. (A.), Blanch, O. (O.), Bonnoli, G. (G.), Bosnjak, Z. (Z.), Busetto, G. (G.), Carosi, R. (R.), Ceribella, G. (G.), Cerruti, M. (M.), Chai, Y. (Y.), Chilingarian, A. (A.), Cikota, S. (S.), Colak, S. M. (S. M.), Colin, U. (U.), Colombo, E. (E.), Contreras, J. L. (J. L.), Cortina, J. (J.), Covino, S. (S.), D'Amico, G. (G.), D'Elia, V. (V), Da Vela, P. (P.), Dazzi, F. (F.), De Angelis, A. (A.), De Lotto, B. (B.), Delfino, M. (M.), Delgado, J. (J.), Depaoli, D. (D.), Di Pierro, F. (F.), Di Venere, L. (L.), Espineira, E. D. (E. Do Souto), Prester, D. D. (D. Dominis), Donini, A. (A.), Dorner, D. (D.), Doro, M. (M.), Elsaesser, D. (D.), Ramazani, V. F. (V. Fallah), Fattorini, A. (A.), Ferrara, G. (G.), Foffano, L. (L.), Fonseca, M. V. (M., V), Font, L. (L.), Fruck, C. (C.), Fukami, S. (S.), Lopez, R. J. (R. J. Garcia), Garczarczyk, M. (M.), Gasparyan, S. (S.), Gaug, M. (M.), Giglietto, N. (N.), Giordano, F. (F.), Gliwny, P. (P.), Godinovic, N. (N.), Green, D. (D.), Hadasch, D. (D.), Hahn, A. (A.), Herrera, J. (J.), Hoang, J. (J.), Hrupec, D. (D.), Huetten, M. (M.), Inada, T. (T.), Inoue, S. (S.), Ishio, K. (K.), Iwamura, Y. (Y.), Jouvin, L. (L.), Kajiwara, Y. (Y.), Karjalainen, M. (M.), Kerszberg, D. (D.), Kobayashi, Y. (Y.), Kubo, H. (H.), Kushida, J. (J.), Lamastra, A. (A.), Lelas, D. (D.), Leone, F. (F.), Lindfors, E. (E.), Lombardi, S. (S.), Longo, F. (F.), Lopez, M. (M.), Lopez-Coto, R. (R.), Lopez-Oramas, A. (A.), Loporchio, S. (S.), Fraga, B. M. (B. Machado de Oliveira), Maggio, C. (C.), Majumdar, P. (P.), Makariev, M. (M.), Mallamaci, M. (M.), Maneva, G. (G.), Manganaro, M. (M.), Mannheim, K. (K.), Maraschi, L. (L.), Mariotti, M. (M.), Martinez, M. (M.), Mazin, D. (D.), Mender, S. (S.), Micanovic, S. (S.), Miceli, D. (D.), Miener, T. (T.), Minev, M. (M.), Miranda, J. M. (J. M.), Mirzoyan, R. (R.), Molina, E. (E.), Moralejo, A. (A.), Morcuende, D. (D.), Moreno, V. (V), Moretti, E. (E.), Munar-Adrover, P. (P.), Neustroev, V. (V), Nigro, C. (C.), Nilsson, K. (K.), Ninci, D. (D.), Nishijima, K. (K.), Noda, K. (K.), Nogues, L. (L.), Nozaki, S. (S.), Ohtani, Y. (Y.), Oka, T. (T.), Otero-Santos, J. (J.), Palatiello, M. (M.), Paneque, D. (D.), Paoletti, R. (R.), Paredes, J. M. (J. M.), Pavletic, L. (L.), Penil, P. (P.), Peresano, M. (M.), Persic, M. (M.), Moroni, P. G. (P. G. Prada), Prandini, E. (E.), Puljak, I. (I), Rhode, W. (W.), Ribo, M. (M.), Rico, J. (J.), Righi, C. (C.), Rugliancich, A. (A.), Saha, L. (L.), Sahakyan, N. (N.), Saito, T. (T.), Sakurai, S. (S.), Satalecka, K. (K.), Schleicher, B. (B.), Schmidt, K. (K.), Schweizer, T. (T.), Sitarek, J. (J.), Snidaric, I. (I), Sobczynska, D. (D.), Spolon, A. (A.), Stamerra, A. (A.), Strom, D. (D.), Strzys, M. (M.), Suda, Y. (Y.), Suric, T. (T.), Takahashi, M. (M.), Tavecchio, F. (F.), Temnikov, P. (P.), Terzic, T. (T.), Teshima, M. (M.), Torres-Alba, N. (N.), Tosti, L. (L.), van Scherpenberg, J. (J.), Vanzo, G. (G.), Acosta, M. V. (M. Vazquez), Ventura, S. (S.), Verguilov, V. (V.), Vigorito, C. F. (C. F.), Vitale, V. (V.), Vovk, I. (I), Will, M. (M.), Zaric, D. (D.), Nievas-Rosillo, M. (M.), Arcaro, C. (C.), D'Ammando, F. (F.), de Palma, F. (F.), Hodges, M. (M.), Hovatta, T. (T.), Kiehlmann, S. (S.), Max-Moerbeck, W. (W.), Readhead, A. C. (A. C. S.), Reeves, R. (R.), Takalo, L. (L.), Reinthal, R. (R.), Jormanainen, J. (J.), Wierda, F. (F.), Wagner, S. M. (S. M.), Berdyugin, A. (A.), Nabizadeh, A. (A.), Sheshvan, N. T. (N. Talebpour), Oksanen, A. (A.), Bachev, R. (R.), Strigachev, A. (A.), Kehusmaa, P. (P.), Acciari, V. A. (V. A.), Ansoldi, S. (S.), Antonelli, L. A. (L. A.), Engels, A. A. (A. Arbet), Baack, D. (D.), Babic, A. (A.), Banerjee, B. (B.), de Almeida, U. B. (U. Barres), Barrio, J. A. (J. A.), Gonzalez, J. B. (J. Becerra), Bednarek, W. (W.), Bellizzi, L. (L.), Bernardini, E. (E.), Berti, A. (A.), Besenrieder, J. (J.), Bhattacharyya, W. (W.), Bigongiari, C. (C.), Biland, A. (A.), Blanch, O. (O.), Bonnoli, G. (G.), Bosnjak, Z. (Z.), Busetto, G. (G.), Carosi, R. (R.), Ceribella, G. (G.), Cerruti, M. (M.), Chai, Y. (Y.), Chilingarian, A. (A.), Cikota, S. (S.), Colak, S. M. (S. M.), Colin, U. (U.), Colombo, E. (E.), Contreras, J. L. (J. L.), Cortina, J. (J.), Covino, S. (S.), D'Amico, G. (G.), D'Elia, V. (V), Da Vela, P. (P.), Dazzi, F. (F.), De Angelis, A. (A.), De Lotto, B. (B.), Delfino, M. (M.), Delgado, J. (J.), Depaoli, D. (D.), Di Pierro, F. (F.), Di Venere, L. (L.), Espineira, E. D. (E. Do Souto), Prester, D. D. (D. Dominis), Donini, A. (A.), Dorner, D. (D.), Doro, M. (M.), Elsaesser, D. (D.), Ramazani, V. F. (V. Fallah), Fattorini, A. (A.), Ferrara, G. (G.), Foffano, L. (L.), Fonseca, M. V. (M., V), Font, L. (L.), Fruck, C. (C.), Fukami, S. (S.), Lopez, R. J. (R. J. Garcia), Garczarczyk, M. (M.), Gasparyan, S. (S.), Gaug, M. (M.), Giglietto, N. (N.), Giordano, F. (F.), Gliwny, P. (P.), Godinovic, N. (N.), Green, D. (D.), Hadasch, D. (D.), Hahn, A. (A.), Herrera, J. (J.), Hoang, J. (J.), Hrupec, D. (D.), Huetten, M. (M.), Inada, T. (T.), Inoue, S. (S.), Ishio, K. (K.), Iwamura, Y. (Y.), Jouvin, L. (L.), Kajiwara, Y. (Y.), Karjalainen, M. (M.), Kerszberg, D. (D.), Kobayashi, Y. (Y.), Kubo, H. (H.), Kushida, J. (J.), Lamastra, A. (A.), Lelas, D. (D.), Leone, F. (F.), Lindfors, E. (E.), Lombardi, S. (S.), Longo, F. (F.), Lopez, M. (M.), Lopez-Coto, R. (R.), Lopez-Oramas, A. (A.), Loporchio, S. (S.), Fraga, B. M. (B. Machado de Oliveira), Maggio, C. (C.), Majumdar, P. (P.), Makariev, M. (M.), Mallamaci, M. (M.), Maneva, G. (G.), Manganaro, M. (M.), Mannheim, K. (K.), Maraschi, L. (L.), Mariotti, M. (M.), Martinez, M. 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Abstract

Context: It has become evident that one-zone synchrotron self-Compton models are not always adequate for very high-energy (VHE) gamma-ray-emitting blazars. While two-component models perform better, they are difficult to constrain due to the large number of free parameters. Aims: In this work, we make a first attempt at taking into account the observational constraints from very long baseline interferometry (VLBI) data, long-term light curves (radio, optical, and X-rays), and optical polarisation to limit the parameter space for a two-component model and test whether or not it can still reproduce the observed spectral energy distribution (SED) of the blazars. Methods: We selected five TeV BL Lac objects based on the availability of VHE gamma-ray and optical polarisation data. We collected constraints for the jet parameters from VLBI observations. We evaluated the contributions of the two components to the optical flux by means of decomposition of long-term radio and optical light curves as well as modelling of the optical polarisation variability of the objects. We selected eight epochs for these five objects based on the variability observed at VHE gamma rays, for which we constructed the SEDs that we then modelled with a two-component model. Results: We found parameter sets which can reproduce the broadband SED of the sources in the framework of two-component models considering all available observational constraints from VLBI observations. Moreover, the constraints obtained from the long-term behaviour of the sources in the lower energy bands could be used to determine the region where the emission in each band originates. Finally, we attempt to use optical polarisation data to shed new light on the behaviour of the two components in the optical band. Our observationally constrained two-component model allows explanation of the entire SED from radio to VHE with two co-located emission regions.

Published
2020

3. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter.

Author

Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, and Davies HM

Subjects
Animals, Basal Ganglia diagnostic imaging, Basal Ganglia metabolism, Blood metabolism, Brain diagnostic imaging, Carrier Proteins antagonists & inhibitors, Cerebellum diagnostic imaging, Cerebellum metabolism, Cocaine pharmacology, Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors pharmacology, Fluorine Radioisotopes, Injections, Intravenous, Kinetics, Macaca mulatta, Male, Rats, Rats, Sprague-Dawley, Brain metabolism, Carrier Proteins metabolism, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Tomography, Emission-Computed, Tropanes
Abstract

A series of PET imaging studies were conducted with two fluorine-18-labeled tropane analoges, [(18)F](+)-FTT and [(18)F](+)-FCT. Both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (DAT) than the cerebellum, a reference region devoid of dopaminergic terminals. [(18)F](+)-FCT had a higher brain uptake and more suitable basal ganglia:cerebellum (BG:Cb) ratio than [(18)F](+)-FTT. [(18)F](+)-FCT also displayed reversible binding kinetics in vivo, indicating that the measurement of DAT density in vivo with PET will be relatively insensitive to changes in cerebral blood flow that can occur as a consequence of disease or prolonged cocaine abuse. The uptake of [(18)F](+)-FCT was also displaced by an intravenous injection of cocaine (1.0 mg/kg), which is consistent with the labeling of the DAT in vivo by this radiotracer. These data suggest that [(18)F](+)-FCT may be a suitable radiotracer for studying DAT function in vivo with PET., (Copyright 2000 Wiley-Liss, Inc.)

Published
2000
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4. Self-administration of cocaine analogs by rats.

Author

Roberts DC, Phelan R, Hodges LM, Hodges MM, Bennett B, Childers S, and Davies H

Subjects
Animals, Dopamine Plasma Membrane Transport Proteins, Male, Rats, Rats, Wistar, Reinforcement Schedule, Self Administration, Serotonin Plasma Membrane Transport Proteins, Tropanes administration & dosage, Carrier Proteins drug effects, Cocaine administration & dosage, Cocaine analogs & derivatives, Cocaine-Related Disorders etiology, Dopamine Antagonists pharmacology, Membrane Glycoproteins drug effects, Membrane Transport Proteins, Nerve Tissue Proteins
Abstract

Rationale: A novel scheme for the synthesis of cocaine analogs from vinylcarbenoid precursors has made available compounds that have a diverse range of affinities for the DA and 5-HT transporters. These compounds were used to explore the relationship between their biochemical properties and their reinforcing effects., Objectives: The objective was to assess the reinforcing efficacy of selected cocaine analogs and compare the results with their selectivity in binding to DA and 5-HT transporters., Methods: Rats were prepared with chronically indwelling intravenous cannulae and trained to self-administer cocaine on a progressive ratio (PR) schedule. A range of doses of seven cocaine analogs were substituted for cocaine in separate groups of animals., Results: The results demonstrate a wide range of reinforcing efficacies and potencies among the seven selected drugs. Four tropane analogs (WF-11, WF-23, WF-24, WF-55) were found to support self-administration behavior on a PR schedule while three did not (WF-31, WF-54 and WF-60). The DA/5-HT selectivity ratio was found to be a better predictor of self-administration behavior than affinity at the DA transporter alone., Conclusion: These data suggest that drugs with a higher affinity for the DA versus the 5-HT transporter are more likely to be self-administered.

Published
1999
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