Search

Your search keyword '"Hodge, James M"' showing total 119 results
Start Over Author "Hodge, James M"
119 results on '"Hodge, James M"'

3. Phylogenomics revealed migration routes and adaptive radiation timing of Holarctic malaria mosquito species of the Maculipennis Group

Author

Yurchenko, Andrey A., Naumenko, Anastasia N., Artemov, Gleb N., Karagodin, Dmitry A., Hodge, James M., Velichevskaya, Alena I., Kokhanenko, Alina A., Bondarenko, Semen M., Abai, Mohammad R., Kamali, Maryam, Gordeev, Mikhail I., Moskaev, Anton V., Caputo, Beniamino, Aghayan, Sargis A., Baricheva, Elina M., Stegniy, Vladimir N., Sharakhova, Maria V., and Sharakhov, Igor V.

Published
2023
Full Text
View/download PDF

4. Case-Cohort Study of the Association between PFAS and Selected Cancers among Participants in the American Cancer Society's Cancer Prevention Study II LifeLink Cohort

Author

Winquist, Andrea, Hodge, James M., Diver, W. Ryan, Rodriguez, Juan L., Troeschel, Alyssa N., Daniel, Johnni, and Teras, Lauren R.

Subjects
United States. National Cancer Institute -- Analysis, United States. Centers for Disease Control and Prevention -- Analysis, Oncology, Experimental -- Health aspects -- Analysis, Ammonium perfluorooctanoate -- Analysis -- Health aspects -- Research, Lymphomas -- Research, Cancer -- Prevention -- Research, Surface active agents -- Analysis -- Health aspects -- Research, Epidemiology -- Analysis -- Health aspects -- Research, Environmental issues, Health
Abstract

BACKGROUND: Previous epidemiological studies found associations between exposure to per- and polyfluoroalkyl substances (PFAS) and some cancer types. Many studies considered highly exposed populations, so relevance to less- exposed populations can be uncertain. Additionally, many studies considered only cancer site, not histology. OBJECTIVES: We conducted a case-cohort study within the American Cancer Society's prospective Cancer Prevention Study II (CPS-II) LifeLink cohort to examine associations between PFAS exposure and risk of selected cancers, considering histologic subtypes. METHODS: Serum specimens were collected from cohort participants during the period 1998-2001. This study included a subcohort (500 men, 499 women) randomly selected from participants without prior cancer diagnoses at serum collection, and all participants with incident (after serum collection) first cancers of the breast (females only, n = 786), bladder (n = 401), kidney (n = 158), pancreas (n = 172), prostate (males only, n = 1,610) or hematologic system (n = 635). PFAS concentrations [perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)] were measured in stored serum. We assessed associations between PFAS concentrations and incident cancers, by site and histologic subtype, using multivariable Cox proportional hazards models stratified by sex and controlling for age and year at blood draw, education, race/ethnicity, smoking, and alcohol use. RESULTS: Serum PFOA concentrations were positively associated with renal cell carcinoma of the kidney among women [hazard ratio (HR) and 95% confidence interval (CI) per PFOA doubling: 1.54 (95% CI: 1.05, 2.26)] but not men. Among men, we observed a positive association between PFHxS concentrations and chronic lymphocytic leukemia/small lymphocytic lymphoma [CLL/SLL, HR and 95% CI per PFHxS doubling: 1.34 (95% CI: 1.02, 1.75)]. We observed some heterogeneity of associations by histologic subtype within sites. Discussion: This study supports the previously observed association between PFOA and renal cell carcinoma among women and suggests an association between PFHxS and CLL/SLL among men. Consideration of histologic subtypes might be important in future studies of PFAS- cancer associations. https://doi.org/10.1289/EHP13174, Introduction Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used since the 1940s in many consumer products such as oil-, water-, and stain-resistant coatings for fabrics, leather, carpets, and food [...]

Published
2023
Full Text
View/download PDF

5. A Population-Based Study of Genes Previously Implicated in Breast Cancer

Author

Hu, Chunling, Hart, Steven N, Gnanaolivu, Rohan, Huang, Hongyan, Lee, Kun Y, Na, Jie, Gao, Chi, Lilyquist, Jenna, Yadav, Siddhartha, Boddicker, Nicholas J, Samara, Raed, Klebba, Josh, Ambrosone, Christine B, Anton-Culver, Hoda, Auer, Paul, Bandera, Elisa V, Bernstein, Leslie, Bertrand, Kimberly A, Burnside, Elizabeth S, Carter, Brian D, Eliassen, Heather, Gapstur, Susan M, Gaudet, Mia, Haiman, Christopher, Hodge, James M, Hunter, David J, Jacobs, Eric J, John, Esther M, Kooperberg, Charles, Kurian, Allison W, Le Marchand, Loic, Lindstroem, Sara, Lindstrom, Tricia, Ma, Huiyan, Neuhausen, Susan, Newcomb, Polly A, O'Brien, Katie M, Olson, Janet E, Ong, Irene M, Pal, Tuya, Palmer, Julie R, Patel, Alpa V, Reid, Sonya, Rosenberg, Lynn, Sandler, Dale P, Scott, Christopher, Tamimi, Rulla, Taylor, Jack A, Trentham-Dietz, Amy, Vachon, Celine M, Weinberg, Clarice, Yao, Song, Ziogas, Argyrios, Weitzel, Jeffrey N, Goldgar, David E, Domchek, Susan M, Nathanson, Katherine L, Kraft, Peter, Polley, Eric C, and Couch, Fergus J

Subjects
Breast Cancer, Genetic Testing, Prevention, Cancer, Clinical Research, Genetics, 2.1 Biological and endogenous factors, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Adult, Aged, Aged, 80 and over, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Middle Aged, Mutation, Odds Ratio, Risk, Sequence Analysis, DNA, Young Adult, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundPopulation-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants.MethodsIn a population-based case-control study, we performed sequencing using a custom multigene amplicon-based panel to identify germline pathogenic variants in 28 cancer-predisposition genes among 32,247 women with breast cancer (case patients) and 32,544 unaffected women (controls) from population-based studies in the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium. Associations between pathogenic variants in each gene and the risk of breast cancer were assessed.ResultsPathogenic variants in 12 established breast cancer-predisposition genes were detected in 5.03% of case patients and in 1.63% of controls. Pathogenic variants in BRCA1 and BRCA2 were associated with a high risk of breast cancer, with odds ratios of 7.62 (95% confidence interval [CI], 5.33 to 11.27) and 5.23 (95% CI, 4.09 to 6.77), respectively. Pathogenic variants in PALB2 were associated with a moderate risk (odds ratio, 3.83; 95% CI, 2.68 to 5.63). Pathogenic variants in BARD1, RAD51C, and RAD51D were associated with increased risks of estrogen receptor-negative breast cancer and triple-negative breast cancer, whereas pathogenic variants in ATM, CDH1, and CHEK2 were associated with an increased risk of estrogen receptor-positive breast cancer. Pathogenic variants in 16 candidate breast cancer-predisposition genes, including the c.657_661del5 founder pathogenic variant in NBN, were not associated with an increased risk of breast cancer.ConclusionsThis study provides estimates of the prevalence and risk of breast cancer associated with pathogenic variants in known breast cancer-predisposition genes in the U.S. population. These estimates can inform cancer testing and screening and improve clinical management strategies for women in the general population with inherited pathogenic variants in these genes. (Funded by the National Institutes of Health and the Breast Cancer Research Foundation.).

Published
2021

13. Patterns of genetic differentiation imply distinct phylogeographic history of the mosquito species Anopheles messeae and Anopheles daciae in Eurasia

Author

Brusentsov, Ilya I., primary, Gordeev, Mikhail I., additional, Yurchenko, Andrey A., additional, Karagodin, Dimitriy A., additional, Moskaev, Anton V., additional, Hodge, James M., additional, Burlak, Vladimir A., additional, Artemov, Gleb N., additional, Sibataev, Anuarbek K., additional, Becker, Norbert, additional, Sharakhov, Igor V., additional, Baricheva, Elina M., additional, and Sharakhova, Maria V., additional

Published
2023
Full Text
View/download PDF

15. Supplementary Tables 1-3 from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Author

Wang, Xiaoliang, primary, Chen, Hongjie, primary, Kapoor, Pooja Middha, primary, Su, Yu-Ru, primary, Bolla, Manjeet K., primary, Dennis, Joe, primary, Dunning, Alison M., primary, Lush, Michael, primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Pharoah, Paul D.P., primary, Hopper, John L., primary, Southey, Melissa C., primary, Koutros, Stella, primary, Freeman, Laura E. Beane, primary, Stone, Jennifer, primary, Rennert, Gad, primary, Shibli, Rana, primary, Murphy, Rachel A., primary, Aronson, Kristan, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Teras, Lauren R., primary, Hodge, James M., primary, Canzian, Federico, primary, Kaaks, Rudolf, primary, Brenner, Hermann, primary, Arndt, Volker, primary, Hoppe, Reiner, primary, Lo, Wing-Yee, primary, Behrens, Sabine, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Jung, Audrey, primary, Becher, Heiko, primary, Giles, Graham G., primary, Haiman, Christopher A., primary, Maskarinec, Gertraud, primary, Scott, Christopher, primary, Winham, Stacey, primary, Simard, Jacques, primary, Goldberg, Mark S., primary, Zheng, Wei, primary, Long, Jirong, primary, Troester, Melissa A., primary, Love, Michael I., primary, Peng, Cheng, primary, Tamimi, Rulla, primary, Eliassen, Heather, primary, García-Closas, Montserrat, primary, Figueroa, Jonine, primary, Ahearn, Thomas, primary, Yang, Rose, primary, Evans, D. Gareth, primary, Howell, Anthony, primary, Hall, Per, primary, Czene, Kamila, primary, Wolk, Alicja, primary, Sandler, Dale P., primary, Taylor, Jack A., primary, Swerdlow, Anthony J., primary, Orr, Nick, primary, Lacey, James V., primary, Wang, Sophia, primary, Olsson, Håkan, primary, Easton, Douglas F., primary, Milne, Roger L., primary, Hsu, Li, primary, Kraft, Peter, primary, Chang-Claude, Jenny, primary, and Lindström, Sara, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure 1 from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Author

Wang, Xiaoliang, primary, Chen, Hongjie, primary, Kapoor, Pooja Middha, primary, Su, Yu-Ru, primary, Bolla, Manjeet K., primary, Dennis, Joe, primary, Dunning, Alison M., primary, Lush, Michael, primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Pharoah, Paul D.P., primary, Hopper, John L., primary, Southey, Melissa C., primary, Koutros, Stella, primary, Freeman, Laura E. Beane, primary, Stone, Jennifer, primary, Rennert, Gad, primary, Shibli, Rana, primary, Murphy, Rachel A., primary, Aronson, Kristan, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Teras, Lauren R., primary, Hodge, James M., primary, Canzian, Federico, primary, Kaaks, Rudolf, primary, Brenner, Hermann, primary, Arndt, Volker, primary, Hoppe, Reiner, primary, Lo, Wing-Yee, primary, Behrens, Sabine, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Jung, Audrey, primary, Becher, Heiko, primary, Giles, Graham G., primary, Haiman, Christopher A., primary, Maskarinec, Gertraud, primary, Scott, Christopher, primary, Winham, Stacey, primary, Simard, Jacques, primary, Goldberg, Mark S., primary, Zheng, Wei, primary, Long, Jirong, primary, Troester, Melissa A., primary, Love, Michael I., primary, Peng, Cheng, primary, Tamimi, Rulla, primary, Eliassen, Heather, primary, García-Closas, Montserrat, primary, Figueroa, Jonine, primary, Ahearn, Thomas, primary, Yang, Rose, primary, Evans, D. Gareth, primary, Howell, Anthony, primary, Hall, Per, primary, Czene, Kamila, primary, Wolk, Alicja, primary, Sandler, Dale P., primary, Taylor, Jack A., primary, Swerdlow, Anthony J., primary, Orr, Nick, primary, Lacey, James V., primary, Wang, Sophia, primary, Olsson, Håkan, primary, Easton, Douglas F., primary, Milne, Roger L., primary, Hsu, Li, primary, Kraft, Peter, primary, Chang-Claude, Jenny, primary, and Lindström, Sara, primary

Published
2023
Full Text
View/download PDF

17. Supplementary Information from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Author

Wang, Xiaoliang, primary, Chen, Hongjie, primary, Kapoor, Pooja Middha, primary, Su, Yu-Ru, primary, Bolla, Manjeet K., primary, Dennis, Joe, primary, Dunning, Alison M., primary, Lush, Michael, primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Pharoah, Paul D.P., primary, Hopper, John L., primary, Southey, Melissa C., primary, Koutros, Stella, primary, Freeman, Laura E. Beane, primary, Stone, Jennifer, primary, Rennert, Gad, primary, Shibli, Rana, primary, Murphy, Rachel A., primary, Aronson, Kristan, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Teras, Lauren R., primary, Hodge, James M., primary, Canzian, Federico, primary, Kaaks, Rudolf, primary, Brenner, Hermann, primary, Arndt, Volker, primary, Hoppe, Reiner, primary, Lo, Wing-Yee, primary, Behrens, Sabine, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Jung, Audrey, primary, Becher, Heiko, primary, Giles, Graham G., primary, Haiman, Christopher A., primary, Maskarinec, Gertraud, primary, Scott, Christopher, primary, Winham, Stacey, primary, Simard, Jacques, primary, Goldberg, Mark S., primary, Zheng, Wei, primary, Long, Jirong, primary, Troester, Melissa A., primary, Love, Michael I., primary, Peng, Cheng, primary, Tamimi, Rulla, primary, Eliassen, Heather, primary, García-Closas, Montserrat, primary, Figueroa, Jonine, primary, Ahearn, Thomas, primary, Yang, Rose, primary, Evans, D. Gareth, primary, Howell, Anthony, primary, Hall, Per, primary, Czene, Kamila, primary, Wolk, Alicja, primary, Sandler, Dale P., primary, Taylor, Jack A., primary, Swerdlow, Anthony J., primary, Orr, Nick, primary, Lacey, James V., primary, Wang, Sophia, primary, Olsson, Håkan, primary, Easton, Douglas F., primary, Milne, Roger L., primary, Hsu, Li, primary, Kraft, Peter, primary, Chang-Claude, Jenny, primary, and Lindström, Sara, primary

Published
2023
Full Text
View/download PDF

18. Data from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Author

Wang, Xiaoliang, primary, Chen, Hongjie, primary, Kapoor, Pooja Middha, primary, Su, Yu-Ru, primary, Bolla, Manjeet K., primary, Dennis, Joe, primary, Dunning, Alison M., primary, Lush, Michael, primary, Wang, Qin, primary, Michailidou, Kyriaki, primary, Pharoah, Paul D.P., primary, Hopper, John L., primary, Southey, Melissa C., primary, Koutros, Stella, primary, Freeman, Laura E. Beane, primary, Stone, Jennifer, primary, Rennert, Gad, primary, Shibli, Rana, primary, Murphy, Rachel A., primary, Aronson, Kristan, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Teras, Lauren R., primary, Hodge, James M., primary, Canzian, Federico, primary, Kaaks, Rudolf, primary, Brenner, Hermann, primary, Arndt, Volker, primary, Hoppe, Reiner, primary, Lo, Wing-Yee, primary, Behrens, Sabine, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Jung, Audrey, primary, Becher, Heiko, primary, Giles, Graham G., primary, Haiman, Christopher A., primary, Maskarinec, Gertraud, primary, Scott, Christopher, primary, Winham, Stacey, primary, Simard, Jacques, primary, Goldberg, Mark S., primary, Zheng, Wei, primary, Long, Jirong, primary, Troester, Melissa A., primary, Love, Michael I., primary, Peng, Cheng, primary, Tamimi, Rulla, primary, Eliassen, Heather, primary, García-Closas, Montserrat, primary, Figueroa, Jonine, primary, Ahearn, Thomas, primary, Yang, Rose, primary, Evans, D. Gareth, primary, Howell, Anthony, primary, Hall, Per, primary, Czene, Kamila, primary, Wolk, Alicja, primary, Sandler, Dale P., primary, Taylor, Jack A., primary, Swerdlow, Anthony J., primary, Orr, Nick, primary, Lacey, James V., primary, Wang, Sophia, primary, Olsson, Håkan, primary, Easton, Douglas F., primary, Milne, Roger L., primary, Hsu, Li, primary, Kraft, Peter, primary, Chang-Claude, Jenny, primary, and Lindström, Sara, primary

Published
2023
Full Text
View/download PDF

20. Additional file 1 of Phylogenomics revealed migration routes and adaptive radiation timing of Holarctic malaria mosquito species of the Maculipennis Group

Author

Yurchenko, Andrey A., Naumenko, Anastasia N., Artemov, Gleb N., Karagodin, Dmitry A., Hodge, James M., Velichevskaya, Alena I., Kokhanenko, Alina A., Bondarenko, Semen M., Abai, Mohammad R., Kamali, Maryam, Gordeev, Mikhail I., Moskaev, Anton V., Caputo, Beniamino, Aghayan, Sargis A., Baricheva, Elina M., Stegniy, Vladimir N., Sharakhova, Maria V., and Sharakhov, Igor V.

Abstract

Additional file 1: Table S1. Statistics of the transcriptome assemblies for species of the Maculipennis Group. Table S2. Genes of An. atroparvus used as markers for detection of interspecies chromosome rearrangements on the X chromosome in five species of the Maculipennis Subgroup. Table S3. Mosquito species and sampling sites. Figure S1. A phylogenetic analysis of ortholog groups split into 4 equally-sized datasets based on the length of the alignments after trimal filtration. Figure S2. A phylogenetic analysis using whole-genome datasets from six Anopheles species.

Published
2023
Full Text
View/download PDF

21. Patterns of genetic differentiation imply distinct evolutionary histories of the sibling mosquito speciesAnopheles messeaeandAnopheles daciaein Eurasia

Author

Brusentsov, Ilya I., primary, Gordeev, Mikhail I., additional, Yurchenko, Andrey A., additional, Karagodin, Dimitriy A., additional, Moskaev, Anton V., additional, Hodge, James M., additional, Burlak, Vladimir A., additional, Artemov, Gleb N., additional, Sibataev, Anuarbek K., additional, Becker, Norbert, additional, Sharakhov, Igor V., additional, Baricheva, Elina M., additional, and Sharakhova, Maria V., additional

Published
2022
Full Text
View/download PDF

22. Phylogenomics revealed migration routes and adaptive radiation timing of Holarctic malaria vectors of the Maculipennis group

Author

Yurchenko, Andrey A., primary, Naumenko, Anastasia N., additional, Artemov, Gleb N., additional, Karagodin, Dmitry A., additional, Hodge, James M., additional, Velichevskaya, Alena I., additional, Kokhanenko, Alina A., additional, Bondarenko, Semen M., additional, Abai, Mohammad R., additional, Kamali, Maryam, additional, Gordeev, Mikhail I., additional, Moskaev, Anton V., additional, Caputo, Beniamino, additional, Aghayan, Sargis A., additional, Baricheva, Elina M., additional, Stegniy, Vladimir N., additional, Sharakhova, Maria V., additional, and Sharakhov, Igor V., additional

Published
2022
Full Text
View/download PDF

23. A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

Author

Wang, Xiaoliang, primary, Chen, Hongjie, additional, Kapoor, Pooja Middha, additional, Su, Yu-Ru, additional, Bolla, Manjeet K., additional, Dennis, Joe, additional, Dunning, Alison M., additional, Lush, Michael, additional, Wang, Qin, additional, Michailidou, Kyriaki, additional, Pharoah, Paul D.P., additional, Hopper, John L., additional, Southey, Melissa C., additional, Koutros, Stella, additional, Freeman, Laura E. Beane, additional, Stone, Jennifer, additional, Rennert, Gad, additional, Shibli, Rana, additional, Murphy, Rachel A., additional, Aronson, Kristan, additional, Guénel, Pascal, additional, Truong, Thérèse, additional, Teras, Lauren R., additional, Hodge, James M., additional, Canzian, Federico, additional, Kaaks, Rudolf, additional, Brenner, Hermann, additional, Arndt, Volker, additional, Hoppe, Reiner, additional, Lo, Wing-Yee, additional, Behrens, Sabine, additional, Mannermaa, Arto, additional, Kosma, Veli-Matti, additional, Jung, Audrey, additional, Becher, Heiko, additional, Giles, Graham G., additional, Haiman, Christopher A., additional, Maskarinec, Gertraud, additional, Scott, Christopher, additional, Winham, Stacey, additional, Simard, Jacques, additional, Goldberg, Mark S., additional, Zheng, Wei, additional, Long, Jirong, additional, Troester, Melissa A., additional, Love, Michael I., additional, Peng, Cheng, additional, Tamimi, Rulla, additional, Eliassen, Heather, additional, García-Closas, Montserrat, additional, Figueroa, Jonine, additional, Ahearn, Thomas, additional, Yang, Rose, additional, Evans, D. Gareth, additional, Howell, Anthony, additional, Hall, Per, additional, Czene, Kamila, additional, Wolk, Alicja, additional, Sandler, Dale P., additional, Taylor, Jack A., additional, Swerdlow, Anthony J., additional, Orr, Nick, additional, Lacey, James V., additional, Wang, Sophia, additional, Olsson, Håkan, additional, Easton, Douglas F., additional, Milne, Roger L., additional, Hsu, Li, additional, Kraft, Peter, additional, Chang-Claude, Jenny, additional, and Lindström, Sara, additional

Published
2022
Full Text
View/download PDF

25. Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Author

Boddicker, Nicholas J., primary, Hu, Chunling, additional, Weitzel, Jeffrey N., additional, Kraft, Peter, additional, Nathanson, Katherine L., additional, Goldgar, David E., additional, Na, Jie, additional, Huang, Hongyan, additional, Gnanaolivu, Rohan D., additional, Larson, Nicole, additional, Yussuf, Amal, additional, Yao, Song, additional, Vachon, Celine M., additional, Trentham-Dietz, Amy, additional, Teras, Lauren, additional, Taylor, Jack A., additional, Scott, Christopher E., additional, Sandler, Dale P., additional, Pesaran, Tina, additional, Patel, Alpa V., additional, Palmer, Julie R., additional, Ong, Irene M., additional, Olson, Janet E., additional, O'Brien, Katie, additional, Neuhausen, Susan, additional, Martinez, Elena, additional, Ma, Huiyan, additional, Lindstrom, Sara, additional, Le Marchand, Loic, additional, Kooperberg, Charles, additional, Karam, Rachid, additional, Hunter, David J., additional, Hodge, James M., additional, Haiman, Christopher, additional, Gaudet, Mia M., additional, Gao, Chi, additional, LaDuca, Holly, additional, Lacey, James V., additional, Dolinsky, Jill S., additional, Chao, Elizabeth, additional, Carter, Brian D., additional, Burnside, Elizabeth S., additional, Bertrand, Kimberly A., additional, Bernstein, Leslie, additional, Auer, Paul W., additional, Ambrosone, Christine, additional, Yadav, Siddhartha, additional, Hart, Steven N., additional, Polley, Eric C., additional, Domchek, Susan M., additional, and Couch, Fergus J., additional

Published
2021
Full Text
View/download PDF

27. Asymmetric Phenotypes of Sterile Hybrid Males From Reciprocal Crosses Between Species of the Anopheles gambiae Complex

Author

Liang, Jiangtao, Hodge, James M., Sharakhov, Igor V., Liang, Jiangtao, Hodge, James M., and Sharakhov, Igor V.

Abstract

Haldane's rule of speciation states that sterility or inviability affects the heterogametic sex of inter-species hybrids. Darwin's corollary to Haldane's rule implies that there are asymmetric phenotypes in inter-species hybrids from reciprocal crosses. Studying the phenotypes of F1 hybrids among closely related species of malaria mosquitoes can assist researchers in identifying the genetic factors and molecular mechanisms of speciation. To characterize phenotypes of sterile hybrid males in the Anopheles gambiae complex, we performed crosses between laboratory strains of An. merus and either An. gambiae or An. coluzzii. The reproductive tracts had normal external morphology in hybrid males from crosses between female An. merus and male An. gambiae or An. coluzzii. Despite being sterile, these males could copulate with females for a normal period of time and could transfer a mating plug to induce female oviposition and monogamy. In contrast, the entire reproductive tracts in hybrid males from crosses between female An. gambiae or An. coluzzii and male An. merus were severely underdeveloped. These males had atrophic testes and reduced somatic organs of the reproductive system including male accessary glands and ejaculatory duct. In addition, hybrid males with underdeveloped reproductive tracts displayed a shorter copulation time with females and failed to induce female oviposition and monogamy due to their inability to form and transfer a plug to females during mating. The asymmetry of the phenotypes associated with hybrid male sterility suggests that different genetic factors and molecular mechanisms are responsible for reproductive isolation in reciprocal crosses among species of the An. gambiae complex.

Published
2021
Full Text
View/download PDF

28. The new Internal Transcribed Spacer 2 diagnostic tool clarifies the taxonomic position and geographic distribution of the North American malaria vector Anopheles punctipennis

Author

Entomology, Fralin Life Sciences Institute, Hodge, James M., Yurchenko, Andrey A., Karagodin, Dmitriy A., Masri, Reem A., Smith, Ryan C., Gordeev, Mikhail I., Sharakhova, Maria V., Entomology, Fralin Life Sciences Institute, Hodge, James M., Yurchenko, Andrey A., Karagodin, Dmitriy A., Masri, Reem A., Smith, Ryan C., Gordeev, Mikhail I., and Sharakhova, Maria V.

Abstract

Background The malaria mosquito Anopheles punctipennis, a widely distributed species in North America, is capable of transmitting human malaria and is actively involved in the transmission of the ungulate malaria parasite Plasmodium odocoilei. However, molecular diagnostic tools based on Internal Transcribed Spacer 2 (ITS2) of ribosomal DNA are lacking for this species. Anopheles punctipennis is a former member of the Anopheles maculipennis complex but its systematic position remains unclear. Methods In this study, ITS2 sequences were obtained from 276 An. punctipennis specimens collected in the eastern and midwestern United States and a simple and robust Restriction Fragment Length Polymorphism approach for species identification was developed. The maximum-likelihood phylogenetic tree was constructed based on ITS2 sequences available through this study and from GenBank for 20 species of Anopheles. Results The analysis demonstrated a consistent ITS2 sequence length and showed no indications of intragenomic variation among the samples based on ITS2, suggesting that An. punctipennis represents a single species in the studied geographic locations. In this study, An. punctipennis was found in urban, rural, and forest settings, suggesting its potential broad role in pathogen transmission. Phylogeny based on ITS2 sequence comparison demonstrated the close relationship of this species with other members of the Maculipennis group. Conclusions This study developed molecular tools based on ITS2 sequences for the malaria vector An. punctipennis and clarified the phylogenetic position of the species within the Maculipennis group.

Published
2021

35. Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts.

Author

Gaudet, Mia M, Deubler, Emily L, Kelly, Rachel S, Diver, W Ryan, Teras, Lauren R, Hodge, James M, Levine, Keith E, Haines, Laura G, Lundh, Thomas, Lenner, Per, Palli, Domenico, Vineis, Paolo, Bergdahl, Ingvar, Gapstur, Susan M, Kyrtopoulos, Soterios A, Gaudet, Mia M, Deubler, Emily L, Kelly, Rachel S, Diver, W Ryan, Teras, Lauren R, Hodge, James M, Levine, Keith E, Haines, Laura G, Lundh, Thomas, Lenner, Per, Palli, Domenico, Vineis, Paolo, Bergdahl, Ingvar, Gapstur, Susan M, and Kyrtopoulos, Soterios A

Abstract

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition - Italy (EPIC-Italy), and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR=1.01, 95% CI 0.76 - 1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR=0.80, 95% CI 0.61 - 1.03) and NSHDS cohorts (continuous RR=0.73, 95% CI 0.54 - 0.97). The inverse association was also evident in the meta-analysis (continuous RR=0.84, 95% CI 0.69 - 1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis.

Published
2019
Full Text
View/download PDF

36. The role of planned giving

Author

Hodge, James M. and Richardson, David B.

Subjects
Planned giving -- Planning, Income tax -- Donations, Tax deductions -- Analysis -- Contributions, gifts, etc., Endowments -- Planning, Business, Library and information science
Published
1990

37. Abstract 2417: Unsupervised deep-learning to identify histopathological features among breast cancers in the Cancer Prevention Study-II Nutrition Cohort

Author

Puvanesarajah, Samantha, primary, Hodge, James M., additional, Evans, Jacob L., additional, Seo, William, additional, Yi, Michelle, additional, Fritz, Michelle M., additional, Macheski-Preston, Mary, additional, Gansler, Ted, additional, Gapstur, Susan M., additional, and Gaudet, Mia M., additional

Published
2019
Full Text
View/download PDF

39. Toxoplasma gondii infection and the risk of adult glioma in two prospective studies.

Author

Hodge, James M., Coghill, Anna E., Kim, Youngchul, Bender, Noemi, Smith-Warner, Stephanie A., Gapstur, Susan, Teras, Lauren R., Grimsrud, Tom K., Waterboer, Tim, and Egan, Kathleen M.

Subjects
TOXOPLASMA gondii, GLIOMAS, CELL surface antigens, LONGITUDINAL method, NERVE tissue
Abstract

Toxoplasma gondii (T gondii) is a common parasite that shows affinity to neural tissue and may lead to the formation of cysts in the brain. Previous epidemiologic studies have suggested an association between glioma and increased prevalence of T gondii infection, but prospective studies are lacking. Therefore, we examined the association between prediagnostic T gondii antibodies and risk of glioma in two prospective cohorts using a nested case-control study design. Cases and matched controls were selected from the American Cancer Society's Cancer Prevention Study-II Nutrition Cohort (CPSII-NC) (n = 37 cases and 74 controls) and the Norwegian Cancer Registry's Janus Serum Bank (Janus) (n = 323 cases and 323 controls). Blood samples collected prior to diagnosis were analyzed for antibodies to two T gondii surface antigens (p22 and sag-1), with individuals considered seropositive if antibodies to either antigen were detected. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95% CI) for each cohort. In both cohorts, a suggestive increase in glioma risk was observed among those infected with T gondii (OR: 2.70; 95% CI: 0.96-7.62 for CPSII-NC; OR: 1.32, 95% CI: 0.85-2.07 for Janus), particularly among participants with high antibody titers specific to the sag-1 antigen (CPSII-NC OR: 3.35, 95% CI: 0.99-11.38; Janus OR: 1.79, 95% CI: 1.02-3.14). Our findings provide the first prospective evidence of an association between T gondii infection and risk of glioma. Further studies with larger case numbers are needed to confirm a potential etiologic role for T gondii in glioma [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

41. Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts

Author

Gaudet, Mia M., primary, Deubler, Emily L., additional, Kelly, Rachel S., additional, Ryan Diver, W., additional, Teras, Lauren R., additional, Hodge, James M., additional, Levine, Keith E., additional, Haines, Laura G., additional, Lundh, Thomas, additional, Lenner, Per, additional, Palli, Domenico, additional, Vineis, Paolo, additional, Bergdahl, Ingvar A., additional, Gapstur, Susan M., additional, and Kyrtopoulos, Soterios A., additional

Published
2018
Full Text
View/download PDF

44. Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts.

Author

Gaudet, Mia M., Deubler, Emily L., Kelly, Rachel S., Ryan Diver, W., Teras, Lauren R., Hodge, James M., Levine, Keith E., Haines, Laura G., Lundh, Thomas, Lenner, Per, Palli, Domenico, Vineis, Paolo, Bergdahl, Ingvar A., Gapstur, Susan M., and Kyrtopoulos, Soterios A.

Abstract

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Prevention Study‐II (CPS‐II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition – Italy (EPIC‐Italy) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma‐mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random‐effects models with each study result weighted by the within‐ and between‐study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut‐points, cadmium levels were not associated with breast cancer risk in the CPS‐II cohort (continuous RR = 1.01, 95% CI 0.76–1.34), but were inversely associated with risk in the EPIC‐ Italy (continuous RR = 0.80, 95% CI 0.61–1.03) and NSHDS cohorts (continuous RR = 0.73, 95% CI 0.54–0.97). The inverse association was also evident in the meta‐analysis (continuous RR = 0.84, 95% CI 0.69–1.01) with low between‐study heterogeneity. Large differences in lead level distributions precluded a meta‐analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta‐analysis. What's new? Do cadmium and lead cause breast cancer? These two notorious toxic metals tend to linger in the body, and both are classified as carcinogens. Ubiquitous environmental contaminants, they accumulate in women particularly, due to their lower iron levels. Yet no definitive link has been demonstrated between cadmium or lead and breast cancer. Here, the authors analyzed three case–control studies. Across the three studies, a wide range of exposure levels was represented, and each study included a large number of participants. The meta‐analysis revealed no association between high levels of cadmium or lead and breast cancer risk. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

50. Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk.

Author

Kalia SS, Boddicker NJ, Yadav S, Huang H, Na J, Hu C, Ambrosone CB, Yao S, Haiman CA, Chen F, John EM, Kurian AW, Guo B, Lindstrӧm S, Auer P, Lacey JV Jr, Neuhausen SL, Martinez ME, Sandler DP, O'Brien KM, Taylor JA, Teras LR, Hodge JM, Lori A, Bodelon C, Trentham-Dietz A, Burnside ES, Vachon CM, Winham SJ, Goldgar DE, Domchek SM, Nathanson KL, Weitzel JN, Couch FJ, and Kraft P

Subjects
Humans, Female, Middle Aged, Case-Control Studies, Risk Factors, Risk Assessment methods, Multifactorial Inheritance, Adult, Aged, Prospective Studies, Polymorphism, Single Nucleotide, Breast Neoplasms genetics, Breast Neoplasms epidemiology, Genetic Predisposition to Disease
Abstract

Background: Breast cancer has been associated with monogenic, polygenic, and epidemiologic (clinical, reproductive, and lifestyle) risk factors, but studies evaluating the combined effects of these factors have been limited., Methods: We extended previous work in breast cancer risk modeling, incorporating pathogenic variants (PV) in six breast cancer predisposition genes and a 105-SNP polygenic risk score (PRS), to include an epidemiologic risk score (ERS) in a sample of non-Hispanic White women drawn from prospective cohorts and population-based case-control studies, with 23,518 cases and 22,832 controls, from the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium., Results: The model predicts 4.4-fold higher risk of breast cancer for postmenopausal women with no predisposition PV and median PRS, but with the highest versus lowest ERS. Overall, women with CHEK2 PVs had >20% lifetime risk of breast cancer. However, 15.6% of women with CHEK2 PVs and a family history of breast cancer, and 45.1% of women with CHEK2 PVs but without a family history of breast cancer, had low (<20%) predicted lifetime risk and thus were below the threshold for MRI screening. CHEK2 PV carriers at the 10th percentile of the joint distribution of ERS and PRS, without a family history of breast cancer, had a predicted lifetime risk similar to the general population., Conclusions: These results illustrate that an ERS, alone and combined with the PRS, can contribute to clinically relevant risk stratification., Impact: Integrating monogenic, polygenic, and epidemiologic risk factors in breast cancer risk prediction models may inform personalized screening and prevention efforts., (©2024 American Association for Cancer Research.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results