Search

Your search keyword '"Hodge, Alexander"' showing total 49 results
Start Over Author "Hodge, Alexander"
49 results on '"Hodge, Alexander"'

2. Athlemaphilia ('aTH, lē ma 'filēa), n. meaningful affective connections with sport

Author

Hodge, Alexander Carl

Subjects
796
Abstract

This thesis amalgamates self-determination and attachment theories with the three-factor theory of anthropomorphism to propose athletes can form meaningful nonhuman attachments to sport, which are experienced similarly to interpersonal attachments, and can predict wellbeing and motivation to engage in sport. This mixed methods thesis employed three studies to develop our understanding of 'athlemaphilic' relationships. The first study explored whether athletes experience athlematic interactions like interpersonal relationships, as well as how interactions with sport are associated with wellbeing. The second study utilised interpretative phenomenological analysis to examine why individuals might turn to sport for support. The final study tested how individuals primed with interpersonal insecurity might recuperate a sense of belongingness by thinking about their athlemaphilic relationships. This thesis offers preliminary support for the notions that athlemaphilic relationships: (a) exist; (b) impact wellbeing and motivation; (c) satisfy the secure base and safe haven functions of attachment figures; (d) are anthropomorphised, and; (e) can compensate for thwarted interpersonal need satisfaction. Throughout this thesis athlemaphilic attachments are compared to attachments to interpersonal others, deities, and objects (i.e., mobile-phones), although it remains unclear which type of attachment they resemble most, or if such direct comparison is even possible. Each relationship may make a unique contribution to wellbeing, and a model which can detect such variation is needed. Overall, this thesis challenges the interpersonal requirement of relatedness according to self-determination theory, broadens the scope of attachment theory, supports context-specific attachment styles, and demonstrates attachment to sport as a concept. Continuing to explore these relationships is necessary to better understand what motivates us to engage, or disengage, in sport, as well as how we generate a sense of health and wellbeing.

Published
2018

3. Human amniotic epithelial cell transplantation is safe and well tolerated in patients with compensated cirrhosis: a first-in-human trial

Author

Lim, Rebecca, primary, Hodge, Alexander, additional, Warner, Sherryne, additional, Moore, Gregory T, additional, Correia, Jeanne, additional, Krause, Mirja, additional, McDonald, Hannah, additional, Chan, Siow T, additional, Goonetilleke, Mihiri, additional, Lyon, Stuart M, additional, and Sievert, William, additional

Published
2024
Full Text
View/download PDF

4. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
Full Text
View/download PDF

5. Late-Life Metabolic Dysfunction-Associated Steatotic Liver Disease and its Association With Physical Disability and Dementia

Author

Clayton-Chubb, Daniel, primary, Kemp, William W, additional, Majeed, Ammar, additional, Woods, Robyn L, additional, Ryan, Joanne, additional, Murray, Anne M, additional, Chong, Trevor T J, additional, Lubel, John S, additional, Tran, Cammie, additional, Hodge, Alexander D, additional, Schneider, Hans G, additional, McNeil, John J, additional, and Roberts, Stuart K, additional

Published
2024
Full Text
View/download PDF

9. Metabolic dysfunction‐associated steatotic liver disease in older adults is associated with frailty and social disadvantage.

Author

Clayton‐Chubb, Daniel, Kemp, William W., Majeed, Ammar, Lubel, John S., Woods, Robyn L., Tran, Cammie, Ryan, Joanne, Hodge, Alexander, Schneider, Hans G., McNeil, John J., and Roberts, Stuart K.

Subjects
OLDER people, NON-alcoholic fatty liver disease, LIVER diseases, FRAILTY, FATTY liver
Abstract

Background & Aims: The burden of metabolic dysfunction‐associated steatotic liver disease (MASLD) is growing rapidly, as is the number of older adults globally. However, relatively few studies have been performed evaluating the prevalence and risk factors for MASLD in older adults. As such, we aimed to identify the prevalence of MASLD in older adults, as well as sociodemographic, clinical, functional and biochemical associations. Methods: The study population included older adults without a history of cardiovascular disease, dementia or independence‐limiting functional impairment who had participated in the ASPirin in Reducing Events in the Elderly (ASPREE) randomised trial. MASLD was defined using the Fatty Liver Index (FLI). Associations were identified using Poisson regression with robust variance for FLI ≥ 60 vs FLI < 30. Results: 9097 Australian participants aged ≥70 years had complete biochemical and anthropometric data to identify MASLD. The study population had a mean age of 75.1 ± 4.3 years and was 45.0% male. Almost one‐third (33.0%) had prevalent MASLD, and the prevalence decreased with increasing age (adjusted RR [aRR] 0.96, 95% CI: 0.96–0.97). MASLD was also negatively associated with social advantage (aRR 0.94, 95% CI: 0.90–0.99) and exercise tolerance and was positively associated with diabetes mellitus (aRR: 1.22, 95% CI: 1.16–1.29), hypertension (aRR: 1.31, 95% CI: 1.22–1.41), male sex (aRR: 1.66, 95% CI: 1.57–1.74), pre‐frailty (aRR: 1.99, 95% CI: 1.82–2.12) and frailty (aRR: 2.36, 95% CI: 2.16–2.56). MASLD and nonalcoholic fatty liver disease (NAFLD) results were 100% concordant. Conclusion: This study in a large cohort of relatively healthy community‐dwelling older adults shows that MASLD is common, decreases with age and is associated with poorer metabolic health, social disadvantage and frailty. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Striatal Activity Reinforces Decisions Along Emergent Axes

Author

Hodge, Alexander

Subjects
Behavioral Neuroscience, Neuroscience
Abstract

Selecting the appropriate action for a given context is fundamental for the survival of vertebrate animals. Given that environmental contexts are dynamic and often novel, decision-making poses a significant computational task. Not only must an action be selected from a vast range of possible actions, it must be matched to the specific environment and must be selected quickly. The basal ganglia are a network of subcortical nuclei that have long been implicated in decisionmaking. The striatum, the input nucleus of the basal ganglia, has specifically been shown to be of importance, due in part to its integration of a wide variety of inputs into two projection populations. Spiny projection neurons of the direct pathway (dSPNs) or indirect pathway (iSPNs) are traditionally though to select for or against specific actions, respectively. However, alternative interpretations assert that dSPNs and iSPNs produce opposing reinforcing signals, rather than directly select actions. Here, we have used a novel combination of closed-loop optogenetic stimulation and self-directed, ethologically-relevant animal behavior to investigate the question of whether dSPNs and iSPNs reinforce or select behavior, as well as how dSPNs and iSPNs interact within their larger circuit context. First, we differentiated between action selection and reinforcement by administering brief optogenetic stimulation of either dSPNs or iSPNs following the detection of self-directed left turns in a Y-maze. To determine whether SPN activity selected the direction of actions, we administered stimulation to SPNs in the right hemisphere, in the left hemisphere, or bilaterally. Analysis of turning behavior showed that dSPNs positively reinforced left turns while iSPNs negatively reinforced left turns. We found this effect in behavioral contexts with and without external rewards, indicating that SPN-mediated reinforcement is not dependent on an external reward. These results demonstrate that the primary projection populations of the striatum reinforce specific behavioral policies rather than directly select behaviors or modulate action value. Next, we utilized the behavioral paradigm that we had previously developed to investigate the precise relationship of dSPNs and iSPNs. We administered optogenetic stimulation of both dSPNs and iSPNs concurrently following left turn detection. We found that stimulation of both dSPNs and iSPNs led to negative reinforcement of left turns. This result was consistent regardless of whether turning was motivated by an external reward or not. Interestingly, we found no generalization of negative reinforcement, even without the inclusion of an external reward. These results indicate that dSPNs and iSPNs are not perfectly opponent populations, but instead have a more nuanced relationship that is nevertheless reinforcing. We next investigated the role of dopamine (DA) in regulating SPN-mediated reinforcement. DA signaling is necessary for the cortico-SPN plasticity by which SPN-mediated reinforcement occurs. DA signaling is also commonly thought to convey reward information. However, we have found that SPN-mediated reinforcement does not require the inclusion of an external reward. To determine the role of striatal DA release in SPN-mediated reinforcement, we stimulated dopaminergic terminals in dorsal striatum following self-directed left turns. We found that DA release following self-directed left turns did not modulate action value, but instead promoted exploration of the initially non-preferred turn direction. This indicates that striatal DA release acts as a value-neutral salience signal, an important distinction that explains the how SPN-mediated reinforcement can occur outside of explicitly rewarded contexts. In the final Chapter, we discuss innovations in the study of ethological animal behavior and its neural correlates, how these innovations can impact the evolution of models of striatal function, and the importance of studying SPNs within their circuit context. Taken together, the results detailed here demonstrate the nuanced interplay between several striatal cell types and how their interactions support striatal reinforcement of animal behavior.

Published
2023
Full Text
View/download PDF

15. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, Ibrahim, additional, Hirota, Keisuke, additional, Ho, Lee Chi, additional, Hodge, Alexander, additional, Hosny, Mohamed, additional, Hou, Xin, additional, Huang, Jiao-Feng, additional, Huang, Yan, additional, Huang, Zhifeng, additional, Huang, Yuan, additional, Huang, Ang, additional, Huang, Xiao-Ping, additional, Hui-ping, Sheng, additional, Hunyady, Bela, additional, Hussein, Mennatallah A., additional, Hussein, Osama, additional, Hussien, Shahinaz Mahmoud, additional, Ibáñez-Samaniego, Luis, additional, Ibdah, Jamal, additional, Ibrahim, Luqman, additional, Ibrahim, Miada, additional, Ibrahim, Ibrahim, additional, Icaza-Chávez, Maria E., additional, Idelbi, Sahar, additional, Idilman, Ramazan Idilman, additional, Ikeda, Mayumi, additional, Indolfi, Giuseppe, additional, Invernizzi, Federica, additional, Irshad, Iram, additional, Isa, Hasan Mohamed Ali, additional, Iskandar, Natacha Jreige, additional, Ismaiel, Abdulrahman, additional, Ismail, Mariam, additional, Ismail, Zulkifli, additional, Ismail, Faisal, additional, Iwamoto, Hideki, additional, Jack, Kathryn, additional, Jacob, Rachael, additional, Jafarov, Fuad, additional, Jafri, Wasim, additional, Jahshan, Helen, additional, Jalal, Prasun K, additional, Jancoriene, Ligita, additional, Janicko, Martin, additional, Jayasena, Hiruni, additional, Jefferies, Meryem, additional, Jha, Vivekanand, additional, Ji, Fanpu, additional, Ji, Yaqiu, additional, Jia, Jidong, additional, Jiang, Changtao, additional, Jiang, Ni, additional, Jiang, Zong-zhe, additional, Jin, Xing, additional, Jin, Yi, additional, Jing, Xu, additional, Jingyu, Qian, additional, Jinjolava, Maia, additional, Jong, FX Himawan Haryanto, additional, Jucov, Alina, additional, Julius, Ibecheole, additional, Kaddah, Mona, additional, Kamada, Yoshihiro, additional, kamal, Abobakr, additional, Kamal, Enas Mohamed, additional, Kamel, Ashraf Sayed, additional, Kao, Jia-Horng, additional, Karin, Maja, additional, Karlas, Thomas, additional, Kashwaa, Mohammad, additional, Katsidzira, Leolin, additional, Kaya, Eda, additional, Kayasseh, M.Azzam, additional, Keenan, Bernadette, additional, Keklikkiran, Caglayan, additional, Keml, William, additional, Khalaf, Deia K., additional, Khalefa, Rofida, additional, Khamis, Sherin, additional, Khater, Doaa, additional, khattab, Hamed, additional, Khavkin, Anatoly, additional, Khlynova, Olga, additional, Khmis, Nabil, additional, Kobyliak, Nazarii, additional, Koffas, Apostolos, additional, Koike, Kazuhiko, additional, Kok, Kenneth Y.Y., additional, Koller, Tomas, additional, Komas, Narcisse Patrice, additional, Korochanskaya, Nataliya V., additional, Koulla, Yannoula, additional, Koya, Shunji, additional, Kraft, Colleen, additional, Kraja, Bledar, additional, Krawczyk, Marcin, additional, Kuchay, Mohammad Shafi, additional, Kulkarni, Anand V, additional, Kumar, Ashish, additional, Kumar, Manoj, additional, Lakoh, Sulaiman, additional, Lam, Philip, additional, Lan, Ling, additional, Lange, Naomi F., additional, Lankarani, Kamran Bagheri, additional, Lanthier, Nicolas, additional, Lapshyna, Kateryna, additional, Lashen, Sameh A., additional, Laure, Konang Nguieguia Justine, additional, Lazebnik, Leonid, additional, Lebrec, Didier, additional, Lee, Samuel S., additional, Lee, Way Seah, additional, Lee, Yeong Yeh, additional, Leeming, Diana Julie, additional, Leite, Nathalie Carvalho, additional, Leon, Roberto, additional, Lesmana, Cosmas Rinaldi Adithya, additional, Li, Junfeng, additional, Li, Qiong, additional, Li, Jun, additional, Li, Yang-Yang, additional, Li, Yufang, additional, Li, Lei, additional, Li, Min, additional, li, Yiling, additional, Liang, Huiqing, additional, Lijuan, Tang, additional, Lim, Seng Gee, additional, Lim, Lee-Ling, additional, Lin, Shumei, additional, Lin, Han-Chieh, additional, Lin, Rita, additional, Lithy, Rania, additional, Liu, Yaru, additional, Liu, Yuanyuan, additional, Liu, Xin, additional, Liu, Wen-Yue, additional, Liu, Shourong, additional, Liu, Ken, additional, Liu, Tian, additional, Lonardo, Amedeo, additional, López, Mariana Bravo, additional, López-Benages, Eva, additional, Lopez-Jaramillo, Patricio, additional, Lu, Huimin, additional, Lu, Lun Gen, additional, Lu, Yan, additional, Lubel, John, additional, Lui, Rashid, additional, Lupasco, Iulianna, additional, Luzina, Elena, additional, Lv, Xiao-Hui, additional, Lynch, Kate, additional, Ma, Hong-Lei, additional, Machado, Mariana Verdelho, additional, Maduka, Nonso, additional, Madzharova, Katerina, additional, Magdaong, Russellini, additional, Mahadeva, Sanjiv, additional, Mahfouz, Amel, additional, Mahmood, Nik Ritza Kosai Nik, additional, Mahmoud, Eman, additional, Mahrous, Mohamed, additional, Maiwall, Rakhi, additional, Majeed, Ammar, additional, Majumdar, Avik, additional, Mak, Loey, additional, Maklouf, Madiha M, additional, Malekzadeh, Reza, additional, Mandato, Claudia, additional, Mangia, Alessandra, additional, Mann, Jake, additional, Mansour, Hala Hussien, additional, Mansouri, Abdellah, additional, Mantovani, Alessandro, additional, Mao, Jun qian, additional, Maramag, Flor, additional, Marchesini, Giulio, additional, Marcus, Claude, additional, Marinho, Rui António Rocha Tato, additional, Martinez-Chantar, Maria L, additional, Martins, Antonieta A. Soares, additional, Marwan, Rana, additional, Mason, Karen Frances, additional, Masoud, Ghadeer, additional, Massoud, Mohamed Naguib, additional, Matamoros, Maria Amalia, additional, Mateos, Rosa Martín, additional, Mawed, Asmaa, additional, Mbanya, Jean Claude, additional, Mbendi, Charles, additional, McColaugh, Lone, additional, McLeod, Duncan, additional, Medina, Juan Francisco Rivera, additional, Megahed, Ahmed, additional, Mehrez, Mai, additional, Memon, Iqbal, additional, Merat, Shahin, additional, Mercado, Randy, additional, Mesbah, Ahmed, additional, Meskini, Taoufik, additional, Metwally, Mayada, additional, Metwaly, Rasha, additional, Miao, Lei, additional, Micah, Eileen, additional, Miele, Luca, additional, Milivojevic, Vladimir, additional, Milovanovic, Tamara, additional, Mina, Yvonne L., additional, Mishkovik, Milan, additional, Mishriki, Amal, additional, Mitchell, Tim, additional, Mohamed, Alshaimaa, additional, Mohamed, Mona, additional, Mohamed, Sofain, additional, Mohammed, Shady, additional, Mohammed, Ahmed, additional, Mohan, Viswanathan, additional, Mohie, Sara, additional, Mokhtar, Aalaa, additional, Moniem, Reham, additional, Montilla, Mabel Segura, additional, Morales, Jose Antonio Orozco, additional, Morata, María María Sánchez, additional, Moreno-Planas, Jose Maria, additional, Morise, Silvia, additional, Mosaad, Sherif, additional, Moselhy, Mohamed, additional, Mostafa, Alaa Mohamed, additional, Mostafa, Ebraheem, additional, Mouane, Nezha, additional, Mousa, Nasser, additional, Moustafa, Hamdy Mahfouz, additional, Msherif, Abeer, additional, Muller, Kate, additional, Munoz, Christopher, additional, Muñoz-Urribarri, Ana Beatriz, additional, Murillo, Omar Alfaro, additional, Mustapha, Feisul Idzwan, additional, Muzurović, Emir, additional, Nabil, Yehia, additional, Nafady, Shaymaa, additional, Nagamatsu, Ayu, additional, Nakajima, Atsushi, additional, Nakano, Dan, additional, Nan, Yuemin, additional, Nascimbeni, Fabio, additional, Naseef, Mirella S., additional, Nashat, Nagwa, additional, Natalia, Taran, additional, Negro, Francesco, additional, Nersesov, Alexander V., additional, Neuman, Manuela, additional, Ng'wanasayi, Masolwa, additional, Ni, Yan, additional, Nicoll, Amanda, additional, Niizeki, Takashi, additional, Nikolova, Dafina, additional, Ningning, Wang, additional, Niriella, Madunil, additional, Nogoibaeva, K.A, additional, Nordien, Rozeena, additional, O Sullivan, Catherine, additional, O'Beirne, James, additional, Obekpa, Solomon, additional, Ocama, Ponsiano, additional, Ochwoto, Missiani, additional, Ogolodom, Michael Promise, additional, Ojo, Olusegun, additional, Okrostsvaridze, Nana, additional, Oliveira, Claudia P., additional, Omaña, Raul Contreras, additional, Omar, Omneya M., additional, Omar, Hanaa, additional, Omar, Mabroka, additional, Omran, Salma, additional, Omran, Reham, additional, Osman, Marian Muse, additional, Owise, Nevin, additional, Owusu-Ansah, Theobald, additional, Padilla- Machaca, P. Martín, additional, Palle, Sirish, additional, Pan, Ziyan, additional, Pan, Xiao-Yan, additional, Pan, Qiuwei, additional, Papaefthymiou, Apostolis, additional, Paquissi, Feliciano Chanana, additional, Par, Gabriella, additional, Parkash, Arit, additional, Payawal, Diana, additional, Peltekian, Kevork M., additional, Peng, Xuebin, additional, Peng, Liang, additional, Peng, Ying, additional, Pengoria, Rahul, additional, Perez, Martina, additional, Pérez, José Luis, additional, Pérez, Norma Marlene, additional, Persico, Marcello, additional, Pessoa, Mário Guimarães, additional, Petta, Salvatore, additional, Philip, Mathew, additional, Plaz Torres, Maria Corina, additional, Polavarapu, Naveen, additional, Poniachik, Jaime, additional, Portincasa, Piero, additional, Pu, Chunwen, additional, Pürnak, Tuğrul, additional, Purwanto, Edhie, additional, Qi, Xiaolong, additional, Qi, Xingshun, additional, Qian, Zibing, additional, Qiang, Zhao, additional, Qiao, Zengpei, additional, Qiao, Liang, additional, Queiroz, Alberto, additional, Rabiee, Atoosa, additional, Radwan, Manal, additional, Rahetilahy, Alain Marcel, additional, Ramadan, Yasmin, additional, Ramadan, Dina, additional, Ramli, Anis Safura, additional, Ramm, Grant A., additional, Ran, Ao, additional, Rankovic, Ivan, additional, RAO, Huiying, additional, Raouf, Sara, additional, Ray, Sayantan, additional, Reau, Nancy, additional, Refaat, Ahmed, additional, Reiberger, Thomas, additional, Remes-Troche, Jose M, additional, Reyes, Eira Cerda, additional, Richardson, Ben, additional, Ridruejo, Ezequiel, additional, Riestra Jimenez, Sergio, additional, Rizk, Ibrahim, additional, Roberts, Stuart, additional, Roblero, Juan Pablo, additional, Robles, Jorge Alberto Prado, additional, Rockey, Don, additional, Rodríguez, Manuel, additional, Rodríguez Hernández, Heriberto, additional, Román, Eva, additional, Romeiro, Fernando Gomes, additional, Romeo, Stefano, additional, Rosales-Zabal, Jose Miguel, additional, Roshdi, Georgina R., additional, Rosso, Natalia, additional, Ruf, Andres, additional, Ruiz, Patricia Cordero, additional, Runes, Nelia R., additional, Ruzzenente, Andrea, additional, Ryan, Marno, additional, Saad, Ahmed, additional, Sabbagh, Eman BE, additional, Sabbah, Meriam, additional, Saber, Shimaa, additional, Sabrey, Reham, additional, Sabry, Ramy, additional, Saeed, Maysaa Abdallah, additional, Said, Dina, additional, Said, Ebada M, additional, Sakr, Mohammad Amin, additional, Salah, Yara, additional, Salama, Rabab Maamoun, additional, Salama, Asmaa, additional, Saleh, Hussein, additional, Saleh, Ahmed, additional, Salem, Ahmed, additional, Salem, Ahmed Thabet, additional, Salifou, Alkassoum, additional, Salih, Aso Faeq, additional, Salman, Abdallah, additional, Samouda, Hanen, additional, Sanai, Faisal, additional, Sánchez-Ávila, Juan Francisco, additional, Sanker, Lakshumanan, additional, Sano, Tomoya, additional, Sanz, Miquel, additional, Saparbu, Tobokalova, additional, Sawhney, Rohit, additional, Sayed, Fatma, additional, Sayed, Sayed A., additional, Sayed, Ashraf Othman, additional, Sayed, Manar, additional, Sebastiani, Giada, additional, Secadas, Laura, additional, Sediqi, Khawaja Qamaruddin, additional, Seif, Sameh, additional, Semida, Nady, additional, Şenateş, Ebubekir, additional, Serban, Elena Daniela, additional, Serfaty, Lawrence, additional, Seto, Wai-Kay, additional, Sghaier, Ikram, additional, Sha, Min, additional, Shabaan, Hamada M., additional, Shalaby, Lobna, additional, Shaltout, Inass, additional, Sharara, Ala I., additional, Sharma, Vishal, additional, Shawa, Isaac Thom, additional, Shawkat, Ahmed, additional, Shawky, Nehal, additional, Shehata, Osama, additional, Sheils, Sinead, additional, Shewaye, Abate Bane, additional, Shi, Guojun, additional, Shi, Junping, additional, Shimose, Shigeo, additional, Shirono, Tomotake, additional, Shou, Lan, additional, Shrestha, Ananta, additional, Shui, Guanghou, additional, Sievert, William, additional, Sigurdardottir, Solveig, additional, Sira, Mostafa Mohamed, additional, Siradj, Riyadh, additional, Sison, Cecilia, additional, Smyth, Linda, additional, Soliman, Reham, additional, Sollano, Jose D, additional, Sombie, Roger, additional, Sonderup, Mark, additional, Sood, Siddharth, additional, Soriano, German, additional, Stedman, Catherine A M, additional, Stefanyuk, Oksana, additional, Štimac, Davor, additional, Strasser, Simone, additional, Strnad, Pavel, additional, Stuart, Katherine, additional, Su, Wen, additional, Su, Minghua, additional, Sumida, Yoshio, additional, Sumie, Shuji, additional, Sun, Dan-Qin, additional, Sun, Jing, additional, Suzuki, Hiroyuki, additional, Svegliati-Baroni, Gianluca, additional, Swar, Mohamed Osman, additional, TAHARBOUCHT, S., additional, Taher, Zenab, additional, Takamura, Saori, additional, Tan, Lin, additional, Tan, Soek-Siam, additional, Tanwandee, Tawesak, additional, Tarek, Sara, additional, Tatiana, Ghelimici, additional, Tavaglione, Federica, additional, Tecson, Gina Y., additional, Tee, Hoi-Poh, additional, Teschke, Rolf, additional, Tharwat, Mostafa, additional, Thong, Vo Duy, additional, Thursz, Mark, additional, Tine, Tulari, additional, Tiribelli, Claudio, additional, Tolmane, Ieva, additional, Tong, Jing, additional, Tongo, Marco, additional, Torkie, Mamdouh, additional, Torre, Aldo, additional, Torres, Esther A, additional, Trajkovska, Meri, additional, Treeprasertsuk, Sombat, additional, Tsutsumi, Tsubasa, additional, Tu, Thomas, additional, Tur, Josep A., additional, Turan, Dilara, additional, Turcan, Svetlana, additional, Turkina, Svetlana, additional, Tutar, Engin, additional, Tzeuton, Christian, additional, Ugiagbe, Rose, additional, Uygun, Ahmet, additional, Vacca, Michele, additional, Vajro, Pietro, additional, Van der Poorten, David, additional, Van Kleef, Laurens A., additional, Vashakidze, Eliza, additional, Velazquez, Carlos Moctezuma, additional, Velazquez, Mirtha Infante, additional, Vento, Sandro, additional, Verhoeven, Veronique, additional, Vespasiani-Gentilucci, Umberto, additional, Vethakkan, Shireene Ratna, additional, Vilaseca, Josep, additional, Vítek, Libor, additional, Volkanovska, Ance, additional, Wallace, Michael, additional, Wan, Wang, additional, Wang, Yan, additional, Wang, Ying, additional, Wang, Xiaolin, additional, Wang, Xuemei, additional, Wang, Chengyan, additional, Wang, Chunjiong, additional, Wang, Mingjie, additional, Wangchuk, Pelden, additional, Weltman, Martin, additional, White, MaryFrances, additional, Wiegand, Johannes, additional, Wifi, Mohamed-Naguib, additional, Wigg, Alan, additional, Wilhelmi, Markus, additional, William, Remon, additional, Wittenburg, Henning, additional, Wu, Shengjie, additional, Wubeneh, Abdu Mohammed, additional, Xia, Hongping, additional, Xiao, Jian, additional, Xiao, Xiao, additional, Xiaofeng, Wang, additional, Xiong, Wanyuan, additional, Xu, Liang, additional, Xu, Jie, additional, Xu, Weiguo, additional, Xu, Jing-Hang, additional, Xu, Keshu, additional, Xu, Yumin, additional, Xu, Shi-Hao, additional, Xu, Meng, additional, Xu, Aimin, additional, Xu, Chengfu, additional, Yan, Hongmei, additional, Yang, Jingyi, additional, Yang, Rui-Xu, additional, Yang, Yating, additional, Yang, Qinhe, additional, Yang, Naibin, additional, Yao, Jia, additional, Yara, Justine, additional, Yaraş, Serkan, additional, Yılmaz, Nimet, additional, Younes, Ramy, additional, younes, Huda, additional, Young, Sona, additional, Youssef, Farah, additional, Yu, Yanyan, additional, Yu, Ming-Lung, additional, Yuan, Jing, additional, Yue, Zhang, additional, Yuen, Man-Fung, additional, Yun, Wang, additional, Yurukova, Nonka, additional, Zakaria, Serag, additional, Zaky, Samy, additional, Zaldastanishvili, Maia, additional, Zapata, Rodrigo, additional, Zare, Nazanin, additional, Zerem, Enver, additional, Zeriban, Nema, additional, Zeshuai, Xu, additional, Zhang, Huijie, additional, Zhang, Xuemei, additional, Zhang, Yupei, additional, Zhang, Wen-Hua, additional, Zhang, Xuchen, additional, Zhang, Yon-ping, additional, Zhang, Yuexin, additional, Zhang, Zhan-qing, additional, Zhao, Jingmin, additional, Zhao, Rong-Rong, additional, Zhao, Hongwei, additional, Zheng, Chao, additional, Zheng, Yijie, additional, Zheng, Ruidan, additional, Zheng, Tian-Lei, additional, Zheng, Kenneth, additional, Zhou, Xi Qiao, additional, Zhou, Yongjian, additional, Zhou, Yu-Jie, additional, Zhou, Hong, additional, Zhou, Ling, additional, Zhou, Yongning, additional, Zhu, Long dong, additional, Zhu, Yong Fen, additional, Zhu, Yueyong, additional, Zhu, Pei-Wu, additional, Ziada, Ebtesam, additional, Ziring, David, additional, Ziyi, Li, additional, Zou, Shanshan, additional, Zou, Zhengsheng, additional, Zou, Huaibin, additional, and Zuart Ruiz, Roberto, additional

Published
2022
Full Text
View/download PDF

16. Global multi-stakeholder endorsement of the MAFLD definition

Author

Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, Zuart Ruiz, Roberto, Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, and Eslam, Mohammed

Published
2022
Full Text
View/download PDF

17. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Author

Francque, Sven M., primary, Bedossa, Pierre, additional, Ratziu, Vlad, additional, Anstee, Quentin M., additional, Bugianesi, Elisabetta, additional, Sanyal, Arun J., additional, Loomba, Rohit, additional, Harrison, Stephen A., additional, Balabanska, Rozalina, additional, Mateva, Lyudmila, additional, Lanthier, Nicolas, additional, Alkhouri, Naim, additional, Moreno, Christophe, additional, Schattenberg, Jörn M., additional, Stefanova-Petrova, Diana, additional, Vonghia, Luisa, additional, Rouzier, Régine, additional, Guillaume, Maeva, additional, Hodge, Alexander, additional, Romero-Gómez, Manuel, additional, Huot-Marchand, Philippe, additional, Baudin, Martine, additional, Richard, Marie-Paule, additional, Abitbol, Jean-Louis, additional, Broqua, Pierre, additional, Junien, Jean-Louis, additional, and Abdelmalek, Manal F., additional

Published
2021
Full Text
View/download PDF

19. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Author

UCL - (SLuc) Service de gastro-entérologie, Francque, Sven M., Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M., Bugianesi, Elisabetta, Sanyal, Arun J., Loomba, Rohit, Harrison, Stephen A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M., Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, Abdelmalek, Manal F., UCL - (SLuc) Service de gastro-entérologie, Francque, Sven M., Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M., Bugianesi, Elisabetta, Sanyal, Arun J., Loomba, Rohit, Harrison, Stephen A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M., Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, and Abdelmalek, Manal F.

Abstract

Background: Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome proliferator-activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis of NASH. Methods: In this phase 2b, double-blind, randomized, placebo-controlled trial, patients with noncirrhotic, highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks. The primary end point was a decrease of at least 2 points in the SAF-A score (the activity part of the Steatosis, Activity, Fibrosis [SAF] scoring system that incorporates scores for ballooning and inflammation) without worsening of fibrosis; SAF-A scores range from 0 to 4, with higher scores indicating more-severe disease activity. Secondary end points included resolution of NASH and regression of fibrosis. Results: A total of 247 patients underwent randomization, of whom 103 (42%) had type 2 diabetes mellitus and 188 (76%) had significant (moderate) or advanced fibrosis. The percentage of patients who had a decrease of at least 2 points in the SAF-A score without worsening of fibrosis was significantly higher among those who received the 1200-mg dose, but not among those who received the 800-mg dose, of lanifibranor than among those who received placebo (1200-mg dose vs. placebo, 55% vs. 33%, P = 0.007; 800-mg dose vs. placebo, 48% vs. 33%, P = 0.07). The results favored both the 1200-mg and 800-mg doses of lanifibranor over placebo for resolution of NASH without worsening of fibrosis (49% and 39%, respectively, vs. 22%), improvement in fibrosis stage of at least 1 without worsening of NASH (48% and 34%, respectively, vs. 29%), and resolution of NASH plus improvement in fibrosis stage of at least 1 (35% and 25%, respectively, vs. 9%). Liver enzyme levels decreased and the levels of the majority of lipid, inflammatory, and fibrosis biomarkers improved in the lan

Published
2021

20. A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH

Author

Francque, Sven, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin Q.M., Bugianesi, Elisabetta, Sanyal, Arun Jayant, Loomba, Rohit, Harrison, Stephen S.A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn Markus, Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean Louis, Abdelmalek, Manal M.F., Francque, Sven, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin Q.M., Bugianesi, Elisabetta, Sanyal, Arun Jayant, Loomba, Rohit, Harrison, Stephen S.A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn Markus, Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean Louis, and Abdelmalek, Manal M.F.

Abstract

BACKGROUND Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis of NASH. METHODS In this phase 2b, double-blind, randomized, placebo-controlled trial, patients with noncirrhotic, highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks. The primary end point was a decrease of at least 2 points in the SAF-A score (the activity part of the Steatosis, Activity, Fibrosis [SAF] scoring system that incorporates scores for ballooning and inflammation) without worsening of fibrosis; SAF-A scores range from 0 to 4, with higher scores indicating more-severe disease activity. Secondary end points included resolution of NASH and regression of fibrosis. RESULTS A total of 247 patients underwent randomization, of whom 103 (42%) had type 2 diabetes mellitus and 188 (76%) had significant (moderate) or advanced fibrosis. The percentage of patients who had a decrease of at least 2 points in the SAF-A score without worsening of fibrosis was significantly higher among those who received the 1200-mg dose, but not among those who received the 800-mg dose, of lanifibranor than among those who received placebo (1200-mg dose vs. placebo, 55% vs. 33%, P=0.007; 800-mg dose vs. placebo, 48% vs. 33%, P=0.07). The results favored both the 1200-mg and 800-mg doses of lanifibranor over placebo for resolution of NASH without worsening of fibrosis (49% and 39%, respectively, vs. 22%), improvement in fibrosis stage of at least 1 without worsening of NASH (48% and 34%, respectively, vs. 29%), and resolution of NASH plus improvement in fibrosis stage of at least 1 (35% and 25%, respectively, vs. 9%). Liver enzyme levels decreased and the levels of the majority of lipid, inflammatory, and fibrosis biomarkers improved in the lanifibran, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

21. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Author

Inventiva Pharma, Francque, Sven, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M., Bugianesi, Elisabetta, Sanyal, Arun J., Loomba, Rohit, Harrison, Stephen A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M., Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, Abdelmalek, Manal F., NATIVE Study Group, Inventiva Pharma, Francque, Sven, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M., Bugianesi, Elisabetta, Sanyal, Arun J., Loomba, Rohit, Harrison, Stephen A., Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M., Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, Abdelmalek, Manal F., and NATIVE Study Group

Abstract

[Background] Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis of NASH., [Methods] In this phase 2b, double-blind, randomized, placebo-controlled trial, patients with noncirrhotic, highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks. The primary end point was a decrease of at least 2 points in the SAF-A score (the activity part of the Steatosis, Activity, Fibrosis [SAF] scoring system that incorporates scores for ballooning and inflammation) without worsening of fibrosis; SAF-A scores range from 0 to 4, with higher scores indicating more-severe disease activity. Secondary end points included resolution of NASH and regression of fibrosis., [Results] A total of 247 patients underwent randomization, of whom 103 (42%) had type 2 diabetes mellitus and 188 (76%) had significant (moderate) or advanced fibrosis. The percentage of patients who had a decrease of at least 2 points in the SAF-A score without worsening of fibrosis was significantly higher among those who received the 1200-mg dose, but not among those who received the 800-mg dose, of lanifibranor than among those who received placebo (1200-mg dose vs. placebo, 55% vs. 33%, P=0.007; 800-mg dose vs. placebo, 48% vs. 33%, P=0.07). The results favored both the 1200-mg and 800-mg doses of lanifibranor over placebo for resolution of NASH without worsening of fibrosis (49% and 39%, respectively, vs. 22%), improvement in fibrosis stage of at least 1 without worsening of NASH (48% and 34%, respectively, vs. 29%), and resolution of NASH plus improvement in fibrosis stage of at least 1 (35% and 25%, respectively, vs. 9%). Liver enzyme levels decreased and the levels of the majority of lipid, inflammatory, and fibrosis biomarkers improved in the lanifibranor groups. The dropout rate for adverse events was less than 5% and was similar across the trial groups. Diarrhea, nausea, peripheral edema, anemia, and weight gain occurred more frequently with lanifibranor than with placebo., [Conclusions] In this phase 2b trial involving patients with active NASH, the percentage of patients who had a decrease of at least 2 points in the SAF-A score without worsening of fibrosis was significantly higher with the 1200-mg dose of lanifibranor than with placebo. These findings support further assessment of lanifibranor in phase 3 trials. (Funded by Inventiva Pharma; NATIVE ClinicalTrials.gov number, NCT03008070. opens in new tab.)

Published
2021

22. Supplemental Material, Appendix_A - Human Amnion Epithelial Cells Produce Soluble Factors that Enhance Liver Repair by Reducing Fibrosis While Maintaining Regeneration in a Model of Chronic Liver Injury

Author

Hodge, Alexander, Andrewartha, Neil, Dinushka Lourensz, Strauss, Robyn, Correia, Jeanne, Mihiri Goonetilleke, Yeoh, George, Lim, Rebecca, and Sievert, William

Subjects
Medicine, Cell Biology
Abstract

Supplemental Material, Appendix_A for Human Amnion Epithelial Cells Produce Soluble Factors that Enhance Liver Repair by Reducing Fibrosis While Maintaining Regeneration in a Model of Chronic Liver Injury by Alexander Hodge, Neil Andrewartha, Dinushka Lourensz, Robyn Strauss, Jeanne Correia, Mihiri Goonetilleke, George Yeoh, Rebecca Lim and William Sievert in Cell Transplantation

Published
2020
Full Text
View/download PDF

32. Novel therapies in chronic liver disease

Author

Hodge, Alexander David

Subjects
Uncategorized
Abstract

This thesis will address the two foremost concerns in clinical hepatology today: finding a treatment for those with cirrhosis and treating the emerging epidemic of non-alcoholic fatty liver disease (NAFLD). These two issues represent the two ends of the chronic liver disease spectrum. End-stage disease is a chronic fibrotic disease, the result of any number of aetiologies. In situations where the underlying cause cannot be treated or the treatment is unsuccessful, there is a need for an anti-fibrotic, liver regenerative treatment to address this cirrhotic end stage. Currently there are no successful therapies and the scarcity of donors and increase in demand means transplantation is not a viable treatment strategy for the majority of people. In Chapters 2 & 3 in my thesis I assessed a novel, readily available, and plentiful cell-based therapy, the amniotic epithelial cell (hAEC). I examined the mechanisms through which hAEC reduce liver scarring by affecting the cell involved in this process, the hepatic stellate cell (HSC). I have shown that hAEC release soluble factors in vitro that have an anti-fibrotic effect on HSC through reduced proliferation, activation, collagen production and increased collagenase activity. In an animal model of chronic liver disease I showed that both hAEC and conditioned media (CM) therapy reduced liver fibrosis. However, only hAEC tempered the expression of liver progenitor cell (LPC) markers in the diseased liver, a marker of disease severity. Furthermore I examined the effects of hAEC on the LPC to assist in the restoration of liver parenchyma in chronic liver disease. I have shown that in vitro, hAEC induce LPC proliferation and differentiation into hepatocytes through soluble factors. These chapters add to the growing body of evidence for the use of hAEC as a therapy in chronic liver disease, which one day may enter human trials. NAFLD is emerging as the most common chronic liver disease in the world. Successful treatment strategies are needed to manage this condition before cirrhosis develops. There are no successful medical therapies for NAFLD, leaving lifestyle modification by diet and exercise the only successful intervention. However, poor adherence to these regimens and poor long-term response necessitates the need for a new approach. In chapter 4 I have explained the results of a 12-week randomised controlled clinical trial (with subsequent 12-week cross over) of a novel lifestyle modification compared to standard care calorie restriction / exercise advice in the treatment of NAFLD and its associated metabolic conditions. I have shown that both intermittent fasting and standard care advice result in weight, total body fat mass and body mass index reduction with improvements in leptin and adiponectin. However, only intermittent fasting resulted in an improvement in transient elastography, waist circumference, visceral fat volume, blood pressure and insulin resistance. Intermittent fasting was also well tolerated and well adhered. When groups crossed over to the alternative arms, those who changed from standard care to intermittent fasting noted continued improvements in weight, waist circumference, total body fat mass and transient elastography. Whereas, those who changed from intermittent fasting to standard care advice gained weight, waist circumference, total body fat mass and developed insulin resistance. Through this pilot study I have shown that counting minutes not calories by adhering to intermittent fasting is a well tolerated, safe and cheap method that in addition to weight and total body fat loss appears to target the liver and visceral adiposity in a way that standard diet and exercise advice do not. I hope that the results of this pilot study can form the basis for further research in larger trials with liver histological endpoints.

Published
2017
Full Text
View/download PDF

38. Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B.

Author

Knight, Virginia, Hodge, Alexander, Sievert, William, Sarah Lim, Goh, Evan, Wong, Ophelia, Marsh, Philip, and de Courten, Barbora

Abstract

There is emerging evidence for the positive effects or benefits of coffee in patients with liver disease. We conducted a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis: liver stiffness assessed by transient elastography (TE). We assessed coffee and tea intake and measured TE in 1018 patients with NAFLD, HCV, and HBV (155 with NAFLD, 378 with HCV and 485 with HBV). Univariate and multivariate regression models were performed taking into account potential confounders. Liver stiffness was higher in males compared to females (p < 0.05). Patients with HBV had lower liver stiffness than those with HCV and NAFLD. After adjustment for age, gender, smoking, alcohol consumption, M or XL probe, and disease state (NAFLD, HCV, and HBV status), those who drank 2 or more cups of coffee per day had a lower liver stiffness (p = 0.044). Tea consumption had no effect (p = 0.9). Coffee consumption decreases liver stiffness, which may indicate less fibrosis and inflammation, independent of disease state. This study adds further evidence to the notion of coffee maybe beneficial in patients with liver disease. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

41. Enhanced stem cell-derived cardiomyocyte differentiation in suspension culture by delivery of nitric oxide using S-nitrosocysteine.

Author

Hodge, Alexander J., Zhong, Juming, and Lipke, Elizabeth A.

Abstract

ABSTRACT The development of cell-based treatments for heart disease relies on the creation of functionally mature stem cell-derived cardiomyocytes employing in vitro culture suspension systems, a process which remains a formidable and expensive endeavor. The use of nitric oxide as a signaling molecule during differentiation has demonstrated the potential for creating increased numbers of spontaneously contracting embryoid bodies in culture; however, the effects of nitric oxide signaling on the function and maturation of stem cell-derived cardiomyocytes is not well understood. In this study, the effects of nitric oxide on mouse embryonic stem cell-derived cardiomyocyte contractile activity, protein, and gene expression, and calcium handling were quantified. Embryoid bodies (EBs) formed using the hanging drop method, were treated with the soluble nitric oxide donor S-nitrosocysteine (CysNO) over a period of 18 days in suspension culture and spontaneous contractile activity was assessed. On day 8, selected EBs were dissociated to form monolayers for electrophysiological characterization using calcium transient mapping. Nitric oxide treatment led to increased numbers of stem cell-derived cardiomyocytes (SC-CMs) relative to non-treated EBs after 8 days in suspension culture. Increased incidence of spontaneous contraction and frequency of contraction were observed from days 8-14 in EBs receiving nitric oxide treatment in comparison to control. Expression of cardiac markers and functional proteins was visualized using immunocytochemistry and gene expression was assessed using qPCR. Cardiac-specific proteins were present in both CysNO-treated and control SC-CMs; however, CysNO treatment during differentiation significantly increased βMHC gene expression in SC-CMs relative to control SC-CMs. Furthermore, increased calcium transient velocity and decreased calcium transient duration was observed for CysNO-treated SC-CMs in comparison to control SC-CMs. Soluble nitric oxide donors, including S-nitrosocysteine, have advantages over other bioactive molecules for use in scalable culture systems in driving cardiac differentiation, since they are inexpensive and the diffusivity of nitric oxide is relatively high. By enabling maintenance of spontaneous contraction in suspension culture and progressing electrophysiological function of resulting SC-CMs toward a more mature phenotype, long-term application of S-nitrosocysteine was shown to be beneficial during cardiac differentiation. Taken together, these results demonstrate the efficiency of nitric oxide as a signaling compound, with implications in the improvement of pluripotent stem cell-derived cardiomyocyte maturation in large-scale culture systems. Biotechnol. Bioeng. 2016;113: 882-894. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

45. Biomimetic materials design for cardiac tissue regeneration.

Author

Dunn, David A., Hodge, Alexander J., and Lipke, Elizabeth A.

Abstract

Cardiovascular disease is the leading cause of death worldwide. In the absence of sufficient numbers of organs for heart transplant, alternate approaches for healing or replacing diseased heart tissue are under investigation. Designing biomimetic materials to support these approaches will be essential to their overall success. Strategies for cardiac tissue engineering include injection of cells, implantation of three-dimensional tissue constructs or patches, injection of acellular materials, and replacement of valves. To replicate physiological function and facilitate engraftment into native tissue, materials used in these approaches should have properties that mimic those of the natural cardiac environment. Multiple aspects of the cardiac microenvironment have been emulated using biomimetic materials including delivery of bioactive factors, presentation of cell-specific adhesion sites, design of surface topography to guide tissue alignment and dictate cell shape, modulation of mechanical stiffness and electrical conductivity, and fabrication of three-dimensional structures to guide tissue formation and function. Biomaterials can be engineered to assist in stem cell expansion and differentiation, to protect cells during injection and facilitate their retention and survival in vivo, and to provide mechanical support and guidance for engineered tissue formation. Numerous studies have investigated the use of biomimetic materials for cardiac regeneration. Biomimetic material design will continue to exploit advances in nanotechnology to better recreate the cellular environment and advance cardiac regeneration. Overall, biomimetic materials are moving the field of cardiac regenerative medicine forward and promise to deliver new therapies in combating heart disease. WIREs Nanomed Nanobiotechnol 2014, 6:15-39. doi: 10.1002/wnan.1241 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

46. The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis

Author

Alhomrani, Majid, Correia, Jeanne, Zavou, Marcus, Leaw, Bryan, Kuk, Nathan, Xu, Rong, Saad, Mohamed I, Hodge, Alexander, Greening, David, Lim, Rebecca, and Sievert, William

Subjects
cardiovascular system, 3. Good health, Uncategorized
Abstract

Background: Hepatic stellate cells (HSCs) are the primary collagen-secreting cells in the liver. While HSCs are the major cell type involved in the pathogenesis of liver fibrosis, hepatic macrophages also play an important role in mediating fibrogenesis and fibrosis resolution. Previously, we observed a reduction in HSC activation, proliferation, and collagen synthesis following exposure to human amnion epithelial cells (hAEC) and hAEC-conditioned media (hAEC-CM). This suggested that specific factors secreted by hAEC might be effective in ameliorating liver fibrosis. hAEC-derived extracellular vesicles (hAEC-EVs), which are nanosized (40-100 nm) membrane bound vesicles, may act as novel cell-cell communicators. Accordingly, we evaluated the efficacy of hAEC-EV in modulating liver fibrosis in a mouse model of chronic liver fibrosis and in human HSC. Methods: The hAEC-EVs were isolated and characterized. C57BL/6 mice with CCl4-induced liver fibrosis were administered hAEC-EV, hAEC-CM, or hAEC-EV depleted medium (hAEC-EVDM). LX2 cells, a human HSC line, and bone marrow-derived mouse macrophages were exposed to hAEC-EV, hAEC-CM, and hAEC-EVDM. Mass spectrometry was used to examine the proteome profile of each preparation. Results: The extent of liver fibrosis and number of activated HSCs were reduced significantly in CCl4-treated mice given hAEC-EVs, hAEC-CM, and hAEC EVDM compared to untreated controls. Hepatic macrophages were significantly decreased in all treatment groups, where a predominant M2 phenotype was observed. Human HSCs cultured with hAEC-EV and hAEC-CM displayed a significant reduction in collagen synthesis and hAEC-EV, hAEC-CM, and hAEC-EVDM altered macrophage polarization in bone marrow-derived mouse macrophages. Proteome analysis showed that 164 proteins were unique to hAEC-EV in comparison to hAEC-CM and hAEC-EVDM, and 51 proteins were co-identified components with the hAEC-EV fraction. Conclusion: This study provides novel data showing that hAEC-derived EVs significantly reduced liver fibrosis and macrophage infiltration to an extent similar to hAEC-EVDM and hAEC-CM. hAEC-EV-based therapy may be a potential therapeutic option for liver fibrosis.

47. Development of Biomimetic Materials for Enhanced Maturation of Engineered Cardiac Tissue

Author

Hodge, Alexander

Subjects
Chemical Engineering
Abstract

The creation of cardiac tissue constructs holds potential in the development of clinical and diagnostic platforms, including the creation of novel treatments for patients with heart disease and cost-effective platforms for drug discovery. Many materials and techniques have been investigated for use in creating engineered cardiac tissue; however, formation of engineered myocardium in vitro, particularly when derived from pluripotent cell sources, often results in the creation of cardiac tissue or cardiomyocytes with functional properties that are markedly different from the native adult myocardium. The use of biomimetic materials, those materials that emulate one or more properties of native tissue, may be necessary for obtaining cardiac tissue demonstrating physiologically-relevant electrophysiological properties. In this document, the ability of biomimetic materials to drive pluripotent stem cell derived cardiac tissue maturation has been investigated. This document first introduces the overall challenges associated with heart disease and drug discovery, which emphasizes the need for biomimetic material-based solutions. A review on current biomaterial-based methods for treating heart disease, as well as background on work utilizing biomimetic materials for cardiac regeneration is presented, as well as current methods for evaluating functional maturity (with an emphasis on quantifying electrophysiology) of cardiomyocytes and cardiac tissue. Next, the design and implementation of an optical mapping platform for assessing calcium wave velocity and calcium transient duration is presented. This combined macroscopic and microscopic imaging system was capable of capturing optical mapping data from samples ranging 21 to 0.5 mm in size at rates in excess of 500 frames per second. After, a study utilizing biomimetic nitric oxide donor S-nitrosocysteine (CysNO) to direct maturation of stem cell derived cardiomyocytes (SC-CMs) is discussed. Differentiating embryoid bodies treated with CysNO developed greater numbers of faster contracting cardiomyocytes in comparison to controls; dissociated SC-CMs treated with CysNO demonstrated improvement in calcium handling via faster calcium transient velocities and shorter calcium transient durations. Next, a study utilizing the conductive polymer polypyrrole (PPy) is presented which evaluated cardiomyocyte survival and development when grown on the novel material. HL-1 cardiomyocytes cultured on PPy-polycaprolactone (PPy-PCL) films demonstrated greater numbers of connexin-43 positive cells in conjunction with faster calcium transient velocities and shorter calcium transient durations in comparison to cells grown on PCL alone. Finally, the response of SC-CMs differentiated on the surface of the novel PPy-PCL material is reported; PPy-PCL supported the growth and viability of dissociated SC-CMs at a comparable number to PCL alone. Together, these studies provide insight into how novel biomimetic materials can be implemented in the creation of functionally-mature cardiac tissue. Additionally, this work demonstrates how a custom optical mapping apparatus can be adapted to assess cardiac maturation among a gamut of different platforms. The ability to direct and evaluate maturity of differentiating cardiomyocytes contributes to the development of clinical and research platforms for improving treatment of heart disease.

Published
2016

48. Serum Transaminases And Older Adults: Distribution And Associations With All-Cause Mortality.

Author

Clayton-Chubb D, Majeed A, Roberts SK, Schneider HG, Commins I, Fitzpatrick J, Woods RL, Ryan J, Hussain SM, Tan N, Lubel JS, Tran C, Hodge AD, McNeil JJ, and Kemp WW

Abstract

Background: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are commonly ordered tests in general medical practice. However, their distribution and significance in older adults is understudied. As such, we aimed to evaluate sex-stratified distribution of both ALT and AST in older adults (≥ 70 years) and assess for associations with mortality., Methods: Post-hoc analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, placebo-controlled trial of daily low-dose aspirin for initially relatively healthy older persons. Univariate analysis and multiple logistic regression were used to explore baseline characteristics. Cox regression and restricted cubic splines were used to examine links between transaminase levels and mortality., Results: Of the 11853 participants with ALT and AST levels, 1054 (8.9%) deaths were recorded over median 6.4 (IQR 5.4-7.6) years. For ALT, the lowest quintiles for males and females were 6-15 U/L and 5-13 U/L respectively; for AST, the lowest quintiles were 8-18 U/L and 7-17 U/L. On both univariate and models adjusted for covariates including age, BMI, frailty, diabetes, and kidney disease, males and females in the lowest quintile of ALT had an increased hazard of mortality (aHR 1.51 [95% CI 1.14-1.99] and aHR 1.39 [95% CI 1.03-1.88] respectively). For the lowest quintile of AST, only males were at increased risk (aHR 1.33 [95% CI 1.04-1.70]). Associations remained significant when removing outliers., Conclusion: Low ALT levels independently confer an increased hazard of mortality for older males and females; low AST only impacted older male survival. Further evaluation of mechanisms would be worthwhile, and re-evaluating the lower limit of normal for ALT in older adults should be considered., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.)

Published
2024
Full Text
View/download PDF

49. Biomimetic materials design for cardiac tissue regeneration.

Author

Dunn DA, Hodge AJ, and Lipke EA

Subjects
Animals, Cardiovascular Diseases, Humans, Tissue Engineering, Biomimetic Materials, Myocardium cytology, Myocardium metabolism, Myocardium ultrastructure, Nanomedicine, Regenerative Medicine
Abstract

Cardiovascular disease is the leading cause of death worldwide. In the absence of sufficient numbers of organs for heart transplant, alternate approaches for healing or replacing diseased heart tissue are under investigation. Designing biomimetic materials to support these approaches will be essential to their overall success. Strategies for cardiac tissue engineering include injection of cells, implantation of three-dimensional tissue constructs or patches, injection of acellular materials, and replacement of valves. To replicate physiological function and facilitate engraftment into native tissue, materials used in these approaches should have properties that mimic those of the natural cardiac environment. Multiple aspects of the cardiac microenvironment have been emulated using biomimetic materials including delivery of bioactive factors, presentation of cell-specific adhesion sites, design of surface topography to guide tissue alignment and dictate cell shape, modulation of mechanical stiffness and electrical conductivity, and fabrication of three-dimensional structures to guide tissue formation and function. Biomaterials can be engineered to assist in stem cell expansion and differentiation, to protect cells during injection and facilitate their retention and survival in vivo, and to provide mechanical support and guidance for engineered tissue formation. Numerous studies have investigated the use of biomimetic materials for cardiac regeneration. Biomimetic material design will continue to exploit advances in nanotechnology to better recreate the cellular environment and advance cardiac regeneration. Overall, biomimetic materials are moving the field of cardiac regenerative medicine forward and promise to deliver new therapies in combating heart disease., (© 2013 Wiley Periodicals, Inc.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results