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336 results on '"Hocquemiller R"'

3. Isolation of montecristin, a key metabolite in biogenesis of acetogenins from Annonna muricata and its structure elucidation by using tandem mass spectrometry

Author

Gleye, C., Laurens, A., Hocquemiller, R., and Cave, A.

Subjects
Antineoplastic agents -- Analysis, Plant metabolites -- Analysis, Organic compounds -- Analysis, Biological sciences, Chemistry
Abstract

The structure of montecristin which is a C37 acetogenin isolated from Annona muricata was analyzed by tandem mass spectrometry (MS/MS) and nuclear magnetic resonance (NMR) spectroscopy. MS/MS and NMR analysis of the acetogenin indicated the presence of two double bonds on the chain in relation to diol and gamma-lactone. Montecristin is also a key intermediate of acetogenins which contains two adjacent methylene groups between the diol system and double bonds.

Published
1997

5. Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. Angustifolium.

Author

1261551, 517692, 669107, 1201818, Rojas de Arias, Gladys Antonieta, Ferreira, María Elena, Torres, Susana, Inchausti, Alba, Nakayama, Héctor, Thouvenel, C., Hocquemiller, R., Fournet, Alain, 1261551, 517692, 669107, 1201818, Rojas de Arias, Gladys Antonieta, Ferreira, María Elena, Torres, Susana, Inchausti, Alba, Nakayama, Héctor, Thouvenel, C., Hocquemiller, R., and Fournet, Alain

Abstract

The crude alkaloidal extract of Zanthoxylum chiloperone stem bark exhibited in vitro activity against various strains of Leishmania ssp. at 100 μg/ml. Two active major constituents were isolated and identified as canthin-6-one and 5-methoxycanthin-6-one. The effect of these compounds was also tested in an in vivo assay using BALB/c mice infected with Leishmania amazonensis. The mice were treated for 5 weeks postinfection with these alkaloids by oral (14 days) or intralesional route (4 days) at 10 mg/kg daily. The reference drug, N-methylglucamine antimonate was administered by subcutaneous injections at 100 mg/kg for 10 days. Intralesional administration of canthin-6-one reduced the parasite burden but not significantly when it was compared with the untreated group, while the reference drug reduced by 91% the parasite loads in the lesion.

Published
2019

6. Screening of New Caledonian and Vanuatu medicinal plants for antiprotozoal activity

Author

1261551, Rojas de Arias, Gladys Antonieta, Billo, M., Fournet, Alain, Cabalion, P., Waikedre, J., Bories, C., Loiseau, C., Prina, E., Yaluff, Gloria, Fourneau, A., Hocquemiller, R., 1261551, Rojas de Arias, Gladys Antonieta, Billo, M., Fournet, Alain, Cabalion, P., Waikedre, J., Bories, C., Loiseau, C., Prina, E., Yaluff, Gloria, Fourneau, A., and Hocquemiller, R.

Abstract

Sixty-seven extracts of 30 medicinal plants traditionally used in New Caledonia or Vanuatu by healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro for their antiprotozoal activity against Leishmania donovani, Leishmania amazonensis and Trypanosoma cruzi. Among the selected plants, Pagiantha cerifera was the most active against both Leishmania species; four extracts were active against promastigotes of Leishmania donovani at EC(50) values inferior to 5 microg/ml. Garcinia pedicillata extract had an EC(50) value of 12.5 microg/ml against intracellular amastigotes of Leishmania amazonensis. Alone Amborella trichopoda reduced by more of 80% the trypomastigotes of Trypanosoma cruzi in the blood.

Published
2019

9. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata

Author

Emile, A., Waikedre, Jean, Herrenknecht, C., Fourneau, C., Gantier, J.C., Hnawia, Edouard, Cabalion, Pierre, Hocquemiller, R., Fournet, Alain, Laboratoire Insulaire du Vivant et de l'Environnement (LIVE), Université de la Nouvelle-Calédonie (UNC), and BUNC, Pole ID

Subjects
CHROMATOGRAPHIE EN PHASE LIQUIDE, FRANGULANINE, MALADIE, WALTHERIONE A, [SDV]Life Sciences [q-bio], ARBUSTE, BIOAUTOGRAPHIE, CHAMPIGNON PARASITE, [SDV] Life Sciences [q-bio], EVALUATION, LUTTE, ISOLEMENT, ALCALOIDE, FONGICIDE, EFFICACITE, AGENT PATHOGENE
Published
2007

12. Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)

Author

Waechter, A.I., Cavé, A., Hocquemiller, R., Bories, C., Munoz, V., and Fournet, Alain

Subjects
endocrine system, ACTIVITE BIOLOGIQUE, PLANTE MEDICINALE, organic chemicals, complex mixtures, LIRIODENINE, LEISHMANIOSE, LYSICAMINE, parasitic diseases, O-METHYLMOSCHATOLINE, ALCALOIDE, TRYPANOSOMIASE HUMAINE, UNONOPSINE, heterocyclic compounds, APORPHINE, TRYPANOSOMIASE ANIMALE
Abstract

On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of #Unonopsis buchtienii$, the alkaloids and sterols isolated from these were studied. Of the alkaloids, lireiodenine exhibited the highest activity against #Leishmania major$ and #L. donovani$ (IC100 = 3.12 micrograms/mL). On the other hand, O-methylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against #Trypanosoma brucei$ with an IC100 of 6.25 micrograms/mL. The highest cytotoxic activities were found with the petroleum ether extracts without alkaloids and with all alkaloids isolated (IC50 is less than 9 micrograms/mL for Vero cell line. (Résumé d'auteur)

Published
1999

13. Experimental treatment of cutaneous leishmaniasis with argentilactone isolated from Annona haematantha

Author

Waechter, A.I., Ferreira, M.E., Fournet, Alain, Rojas de Arias, A., Nakayama, H., Torres, S., Hocquemiller, R., and Cavé, A.

Subjects
TRAITEMENT MEDICAL, EXTRACTION, EXPERIMENTATION IN VITRO, LEISHMANIOSE, SUBSTANCE NATURELLE, LEISHMANIOSE CUTANEE, SOURIS BALBC, EFFICACITE, ARGENTILACTONE
Abstract

From the hexanic extract of roots of #Annona haematantha$ an alpha,bêta-unsaturated delta-lactone was isolated and identified as argentilactone. This compound exhibited in vitro activity against various strains of #Leishmania$ ssp. at 10 microg/ml. BALB/c mice infected with #Leishmania amazonensis$ were treated four weeks after infection with argentilactone by oral or subcutaneous routes for 14 days at 25 mg/kg daily. The reference drug, N-methylglucamine antimonate, was administratered by subcutaneous injections at 100 mg/kg for 14 days. In these conditions, argentilactone showed the same efficacy as the reference drug, reducing by 96% the parasite loads in the lesion and by 50% the parasite burden in spleen. (Résumé d'auteur)

Published
1997

14. The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice

Author

Gantier, J.C., Fournet, Alain, Munos, M.H., and Hocquemiller, R.

Subjects
PLANTE MEDICINALE, ACTIVITE BIOLOGIQUE, SUBSTANCE NATURELLE, parasitic diseases, ALCALOIDE, QUINOLINE
Abstract

We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of #Galipea longiflora$. BALB/c mice infected with #Plasmodium vinckei petteri$ were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the #Leishmania$ murine infection, 2-n-pentylquinoline showed activity against #P. vinckei petteri$. This result seems to confirm the antimalarial efficacy of infused stem bark of #G. longiflora$. (Résumé d'auteur)

Published
1996

34. The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism

Author

Lannuzel, A, primary, Michel, P.P, additional, Höglinger, G.U, additional, Champy, P, additional, Jousset, A, additional, Medja, F, additional, Lombès, A, additional, Darios, F, additional, Gleye, C, additional, Laurens, A, additional, Hocquemiller, R, additional, Hirsch, E.C, additional, and Ruberg, M, additional

Published
2003
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