Search

Your search keyword '"Hockfield, Susan"' showing total 165 results
Start Over Author "Hockfield, Susan"
165 results on '"Hockfield, Susan"'

19. Cues intrinsic to the spinal cord determine the pattern and timing of primary afferent growth

Author

Redmond, Lori, Xie, Huiwen, Ziskind-Conhaim, Lea, and Hockfield, Susan

Subjects
Afferent pathways -- Physiological aspects, Axons -- Physiological aspects, Gene expression -- Analysis, Calcitonin -- Analysis, Spinal cord -- Physiological aspects, Central nervous system -- Physiological aspects, Biological sciences
Abstract

We have used organotypic cultures of embryonic rat spinal cord and dorsal root ganglia (DRG) to study the development of central projections of primary sensory afferent axons that express calcitonin gene-related peptide (CGRP). In vivo, small-and medium-diameter CGRP-positive primary afferents terminate in laminae I, II, and V of the spinal cord and do not enter the ventral horn. A similar pattern of CGRP-positive axonal projections was observed in spinal cord slices of Day 16 embryos (E16) maintained in culture for 6 days. Both intact and dissociated DRG neurons showed the same pattern of central arborization, indicating that complex intercellular interactions between DRG neurons are not required for laminar specific targeting. Furthermore, targeting to the dorsal horn and avoidance of the ventral horn was observed in isolated dorsal and ventral hemicords, suggesting that separate mechanisms mediate the avoidance of CGRP-positive axons from the ventral horn and the elaboration of the afferent arbors within the dorsal horn. CGRP-positive afferents can grow into the dorsal horn only during a brief time window. Cultures of age-matched (isochronic) DRG and spinal cord from E14, E16, and E18 animals showed the characteristic pattern of CGRP-positive axon arborization, while cultures from E20 and neonatal animals did not. Heterochronic cultures indicate that it is the age of the spinal cord, and not the age of the DRG, that determines the ability of the CGRP-positive afferents to arborize within the dorsal horn. Together these results demonstrate that cues intrinsic to the spinal cord can direct sensory projections to appropriate locations in the spinal cord.

Published
1997

21. Electrical activity in the neuromuscular unit can influence the molecular development of motor neurons

Author

Kalb, Robert Gordon and Hockfield, Susan

Subjects
Motor neurons -- Growth, Neuromuscular transmission -- Analysis, Biological sciences
Abstract

The expression of motor neuron cell surface protoglycans recognized by monoclonal antibody Cat-301 in the hamster, is analyzed. The acquisition of mature molecular characteristics by motor neurons can be affected by electrical activity inside the neuromuscular unit in early postnatal life.

Published
1994

22. Cortical development and experience

Author

Hockfield, Susan and Lombroso, Paul J.

Subjects
Cerebral cortex -- Growth, Growth factors -- Psychological aspects, Neural circuitry -- Physiological aspects, Family and marriage, Psychology and mental health
Abstract

Recent studies show that growth factors strongly influence the activity-dependent modification of the neuronal structure. Growth factors are also involved in the survival of neurons and in the growth of axons. Similar studies suggest that these same growth factors also play a role in the growth of dendrites in the visual cortex. Likewise, these growth factors improve synapses following their activation.

Published
1998

25. Manufacturing a Recovery

Author

Hockfield, Susan

Subjects
Inventions -- Economic aspects, Manufacturing industry -- Analysis, United States economic conditions -- Forecasts and trends, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Cambridge, Mass. THE United States became the world's largest economy because we invented products and then made them with new processes. With design and fabrication side by side, insights from [...]

Published
2011

32. Differential Proteome Analysis of Replicative Senescence in Rat Embryo Fibroblasts

Author

Benvenuti, Silvia, primary, Cramer, Rainer, additional, Quinn, Christopher C., additional, Bruce, Jim, additional, Zvelebil, Marketa, additional, Corless, Steven, additional, Bond, Jacquelyn, additional, Yang, Alice, additional, Hockfield, Susan, additional, Burlingame, Alma L., additional, Waterfield, Michael D., additional, and Jat, Parmjit S., additional

Published
2002
Full Text
View/download PDF

38. Of the 35 young innovators recognized this year by Technology Review magazine for their exceptional new ideas

Author

Hockfield, Susan

Subjects
Entrepreneurship -- Achievements and awards, Businesspeople -- Achievements and awards, Publishing industry -- Achievements and awards, Publishing industry, Business, general, Business, Engineering and manufacturing industries
Abstract

Of the 35 young innovators recognized this year by Technology Review magazine for their exceptional new ideas, only six went to high school in the United States.'--MIT president Susan Hockfield [...]

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results