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Your search keyword '"Hobernik, Dominika"' showing total 14 results
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14 results on '"Hobernik, Dominika"'

1. Transcriptional Targeting of Dendritic Cells Using an Optimized Human Fascin1 Gene Promoter

Author

Zeyn, Yanira, primary, Hobernik, Dominika, additional, Wilk, Ulrich, additional, Pöhmerer, Jana, additional, Hieber, Christoph, additional, Medina-Montano, Carolina, additional, Röhrig, Nadine, additional, Strähle, Caroline F., additional, Thoma-Kress, Andrea K., additional, Wagner, Ernst, additional, Bros, Matthias, additional, and Berger, Simone, additional

Published
2023
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6. Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

Author

Stickdorn, Judith, primary, Stein, Lara, additional, Arnold-Schild, Danielle, additional, Hahlbrock, Jennifer, additional, Medina-Montano, Carolina, additional, Bartneck, Joschka, additional, Ziß, Tanja, additional, Montermann, Evelyn, additional, Kappel, Cinja, additional, Hobernik, Dominika, additional, Haist, Maximilian, additional, Yurugi, Hajime, additional, Raabe, Marco, additional, Best, Andreas, additional, Rajalingam, Krishnaraj, additional, Radsak, Markus P., additional, David, Sunil A., additional, Koynov, Kaloian, additional, Bros, Matthias, additional, Grabbe, Stephan, additional, Schild, Hansjörg, additional, and Nuhn, Lutz, additional

Published
2022
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7. Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

Author

Kappel, Cinja, primary, Seidl, Christine, additional, Medina-Montano, Carolina, additional, Schinnerer, Meike, additional, Alberg, Irina, additional, Leps, Christian, additional, Sohl, Julian, additional, Hartmann, Ann-Kathrin, additional, Fichter, Michael, additional, Kuske, Michael, additional, Schunke, Jenny, additional, Kuhn, Gabor, additional, Tubbe, Ingrid, additional, Paßlick, David, additional, Hobernik, Dominika, additional, Bent, Rebekka, additional, Haas, Katharina, additional, Montermann, Evelyn, additional, Walzer, Kerstin, additional, Diken, Mustafa, additional, Schmidt, Manfred, additional, Zentel, Rudolf, additional, Nuhn, Lutz, additional, Schild, Hansjörg, additional, Tenzer, Stefan, additional, Mailänder, Volker, additional, Barz, Matthias, additional, Bros, Matthias, additional, and Grabbe, Stephan, additional

Published
2021
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8. The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog

Author

Klein, Noreen, Kümmerer, Nadine, Hobernik, Dominika, and Schneider, Dirk

Subjects
wt, wild-type, GpA, glycophorin A, HM, half-membrane-spanning, urogenital system, QH301-705.5, Aquaporin, Nephrogenic diabetes insipidus, AQP ER, endoplasmic reticulum, GlpF, glycerol facilitator, Activity, Protein oligomerization, Research article, NDI, nephrogenic diabetes insipidus, AVP, arginine vasopressin, GlpF, 500 Natural sciences and mathematics, AQP, aquaporin, 500 Naturwissenschaften, Biology (General), AVPR2, V2 receptor, ComputingMethodologies_COMPUTERGRAPHICS, TM, transmembrane
Abstract

Graphical abstract, Highlights • The aquaporin 2 mutation V71M causes nephrogenic diabetes insipidus in humans. • Val71 is highly conserved in aqua(glycero)porins and points into the translocation pore. • The V71M mutation does not impair the activity and oligomerization of a bacterial homolog., Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causes nephrogenic diabetes insipidus in humans, on aquaporin structure and activity, using the bacterial aquaglyceroporin GlpF as a model. Importantly, the sequence and structure around the V71M mutation is highly conserved between aquaporin 2 and GlpF. The V71M mutation neither impairs substrate flux nor oligomerization of the aquaglyceroporin. Therefore, the human aquaporin 2 mutant V71M is most likely active, but cellular trafficking is probably impaired.

Published
2015

12. Vaccination with trifunctional nanoparticles that address CD8+ dendritic cells inhibits growth of established melanoma

Author

Shen, Limei, primary, Krauthäuser, Susanne, additional, Fischer, Karl, additional, Hobernik, Dominika, additional, Abassi, Yasmin, additional, Dzionek, Andrzej, additional, Nikolaev, Alexej, additional, Voltz, Nicole, additional, Diken, Mustafa, additional, Krummen, Mathias, additional, Montermann, Evelyn, additional, Tubbe, Ingrid, additional, Lorenz, Steffen, additional, Strand, Dennis, additional, Schild, Hansjörg, additional, Grabbe, Stephan, additional, and Bros, Matthias, additional

Published
2016
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14. Vaccination with trifunctional nanoparticles that address CD8 + dendritic cells inhibits growth of established melanoma.

Author

Shen L, Krauthäuser S, Fischer K, Hobernik D, Abassi Y, Dzionek A, Nikolaev A, Voltz N, Diken M, Krummen M, Montermann E, Tubbe I, Lorenz S, Strand D, Schild H, Grabbe S, and Bros M

Subjects
Animals, Antibodies chemistry, Antibodies immunology, Antigens, CD immunology, Cell Proliferation, CpG Islands, Dendritic Cells metabolism, Dextrans chemistry, Fluorescent Dyes chemistry, Humans, Immunotherapy, Lectins, C-Type immunology, Lymphocyte Activation, Magnetite Nanoparticles therapeutic use, Melanoma, Experimental immunology, Melanoma, Experimental pathology, Mice, Inbred C57BL, Minor Histocompatibility Antigens immunology, Oligonucleotides chemistry, Receptors, Cell Surface immunology, Surface Properties, Tumor Burden, Vaccination, CD8 Antigens metabolism, Dendritic Cells immunology, Magnetite Nanoparticles chemistry, Melanoma, Experimental therapy, Oligonucleotides immunology, Ovalbumin immunology
Abstract

Aim: We wanted to assess the potency of a trifunctional nanoparticle (NP) that targeted and activated CD8 + dendritic cells (DC) and delivered an antigen to induce antitumor responses., Materials & Methods: The DC targeting and activating properties of ferrous NPs conjugated with immunostimulatory CpG-oligonucleotides, anti-DEC205 antibody and ovalbumin (OVA) as a model antigen to induce antigen-specific T-cell responses and antitumor responses were analyzed., Results: OVA-loaded NP conjugated with immunostimulatory CpG-oligonucleotides and anti-DEC205 antibody efficiently targeted and activated CD8 + DC in vivo, and induced strong OVA-specific T-cell activation. Vaccination of B16/OVA tumor-burdened mice with this NP formulation resulted in tumor growth arrest., Conclusion: CD8 + DC-targeting trifunctional nanocarriers bear significant potential for antitumor immunotherapy.

Published
2016
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