39 results on '"Hoarau, Marie"'
Search Results
2. Sharing an Autonomous Taxi Without a Driver Through Guided Imaginary Projection to Identify Sources of (Dis)comfort
- Author
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Cahour, Beatrice, Hoarau, Marie, Rossi, Anna, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Black, Nancy L., editor, Neumann, W. Patrick, editor, and Noy, Ian, editor
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- 2021
- Full Text
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3. Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activity.
- Author
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Decharuangsilp, Sasithorn, Arwon, Uthai, Sooksai, Nawarat, Rattanajak, Roonglawan, Saeyang, Thanaya, Vitsupakorn, Danoo, Vanichtanankul, Jarunee, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee, and Hoarau, Marie
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- 2024
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4. Sharing an Autonomous Taxi Without a Driver Through Guided Imaginary Projection to Identify Sources of (Dis)comfort
- Author
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Cahour, Beatrice, primary, Hoarau, Marie, additional, and Rossi, Anna, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
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Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, øddegård, Rønnaug, Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, and Njølstad, Pål R
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- 2018
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6. L’usage du numérique pour les apprentissages des collégiens dyslexiques : le cas des tablettes tactiles numériques et de l’application S.
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Leclère, Marie, primary, Vidal-Gomel, Christine, additional, and Hoarau, Marie, additional
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- 2023
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7. Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation
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Jones, Michael R., Dyrager, Christine, Hoarau, Marie, Korshavn, Kyle J., Lim, Mi Hee, Ramamoorthy, Ayyalusamy, and Storr, Tim
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- 2016
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8. Coordination complexes and biomolecules: A wise wedding for catalysis upgrade
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Hoarau, Marie, Hureau, Christelle, Gras, Emmanuel, and Faller, Peter
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- 2016
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9. Discovery Of Rigid Biphenyl Plasmodium Falciparum DHFR Inhibitors Using A Fragment Linking Strategy
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Hoarau, Marie, primary, Sermmai, Patpanat, additional, Varatthan, Thaveechai, additional, Thiabma, Ratthiya, additional, Jantra, Tararat, additional, Rattanajak, roonglawan, additional, Vitsupakorn, Danoo, additional, Vanichtanankul, Jarunee, additional, Saepua, Siriporn, additional, Yuthavong, Yongyuth, additional, Thongpanchang, Chawanee, additional, and Kamchonwongpaisan, Sumalee, additional
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- 2023
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10. Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activityElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4md00197d
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Decharuangsilp, Sasithorn, Arwon, Uthai, Sooksai, Nawarat, Rattanajak, Roonglawan, Saeyang, Thanaya, Vitsupakorn, Danoo, Vanichtanankul, Jarunee, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee, and Hoarau, Marie
- Abstract
As pregnant women and young children remain the first victims of malaria worldwide, the search for new antimalarials has been focusing on compounds with a high safety profile and extended efficacy. In a previous study, a rigid biphenyl PfDHFR inhibitor was developed by fragment-based screening, displaying sub nM enzyme inhibition but poor antiparasitic activity, presumably due to its low flexibility. Here, we report a new series of compounds that combines the biphenyl fragment with a flexible linker. Interestingly, their mode of binding differs from previously reported compounds, taking advantage of strong hydrophobic interaction. The new flexible biphenyl compounds show overall improved antiparasitic activity compared to rigid ones, with the best compound displaying a 2 nM antiplasmodial IC50and suitable drug-like properties. This confirms the importance of compound flexibility for antimalarial activity and opens the way to new opportunities for antimalarial drug design.
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- 2024
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11. Assay Development and Identification of the First Plasmodium falciparum 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors
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Hoarau, Marie, primary, Suwanakitti, Nattida, additional, Varatthan, Thaveechai, additional, Thiabma, Ratthiya, additional, Rattanajak, Roonglawan, additional, Charoensetakul, Netnapa, additional, Redman, Emily K., additional, Khotavivattana, Tanatorn, additional, Vilaivan, Tirayut, additional, Yuthavong, Yongyuth, additional, and Kamchonwongpaisan, Sumalee, additional
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- 2022
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12. Partage d'un robot-taxi autonome par projection imaginaire guidée : quelles sources de confort/inconfort dues à l'absence de chauffeur ?
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Hoarau, Marie, Cahour, Béatrice, Télécom Paris, Institut Polytechnique de Paris (IP Paris), Département Sciences Economiques et Sociales (SES), Télécom ParisTech, Interaction, Technologies, Activités (INTERACT), Institut interdisciplinaire de l’innovation (I3, une unité mixte de recherche CNRS (UMR 9217)), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
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ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2021
13. Les effets des pratiques corporelles en classe sur l’attention des élèves et la posture de l’enseignant
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Hoarau, Marie-Amélie, Lauret, Maëva, Institut national supérieur du professorat et de l'éducation - Académie de La Réunion (INSPÉ Réunion), Université de La Réunion (UR), and Elsa Siguier
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Corps ,Movement ,Mouvement ,[SHS.EDU]Humanities and Social Sciences/Education ,Class climate ,Learning ,Climat de classe ,Attention ,Body ,Apprentissage - Abstract
During class, more and more pupils wag, which affects their attention. Faced with this difficulty, teachers are tense and have problems with managing their groups.The aim of this report is to assess how motor-activities in class affect pupils’ attention and teachers’ postures. Therefore, we asked ourselves how engaging pupils' motor-activities in class can benefits their attention, improve their learning abilities and guide teachers towards a better class management?To answer this question, we drew hypotheses from our researches. The first hypothesis suggests that implementing motor-activities improves pupils’ attention. The second one highlights the idea that such practices allow teachers to create a more serene atmosphere for their class.To verify these hypotheses, we carried out a field survey with a preschool and a first-grade classes. We also conduct a self-administered questionnaire intended for teachers. This made it possible to compare the results of our survey with those of teachers who have also implemented such activities in their classes. The results of the survey confirm that motor-activities foster pupils’ attention and contribute to soothe the classroom’s environment.Further researches and experiments should make it possible to reinforce this teaching method in class to transform it into a real “class culture”.; En classe, de plus en plus d’élèves sont agités ce qui a pour conséquence d’affecter leur attention au cours de leur apprentissage. Face à cette difficulté, les enseignants sont tendus et ont dû mal à gérer le groupe classe. L’objectif de cette étude est d’évaluer les effets des pratiques motrices en classe sur l’attention des élèves et la posture de l’enseignant. La problématique est par conséquent la suivante : dans quelle mesure engager l’activité motrice des élèves en classe, peut favoriser leur attention et guider l’enseignant vers une meilleure gestion du groupe ?Pour répondre à cette problématique, des hypothèses de recherches ont été définies. La première suggère que la mise en place d’activités motrices favoriserait l’attention des élèves. La seconde, met en avant l’idée que ces pratiques permettraient à l’enseignant d’instaurer un climat de classe plus serein. Afin de pouvoir vérifier ces hypothèses, une enquête sur le terrain a été menée afin de collecter des données. De plus, un questionnaire auto-administré destiné aux enseignants a permis de comparer les données de l’enquête à ceux des enseignants ayant mis en place ce dispositif dans leur classe. Dans le cadre d’une démarche comparative, les résultats recensés et analysés montrent que les activités corporelles favorisent l’attention des élèves et contribuent à un climat de classe plus apaisé. Des recherches ultérieures devraient permettre de renforcer ce dispositif au sein des classes afin de le transformer en véritable « culture de classe ».
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- 2021
14. Molecular Structure of the Surface-Immobilized Super Uranyl Binding Protein
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Guo, Wen, primary, Zou, Xingquan, additional, Jiang, Hanjie, additional, Koebke, Karl J., additional, Hoarau, Marie, additional, Crisci, Ralph, additional, Lu, Tieyi, additional, Wei, Tao, additional, Marsh, E. Neil G., additional, and Chen, Zhan, additional
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- 2021
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15. Discovery of rigid biphenyl Plasmodium falciparumDHFR inhibitors using a fragment linking strategyElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00242j
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Hoarau, Marie, Sermmai, Patpanat, Varatthan, Thaveechai, Thiabma, Ratthiya, Jantra, Tararat, Rattanajak, Roonglawan, Vitsupakorn, Danoo, Vanichtanankul, Jarunee, Saepua, Siriporn, Yuthavong, Yongyuth, Thongpanchang, Chawanee, and Kamchonwongpaisan, Sumalee
- Abstract
Plasmodium falciparumdihydrofolate reductase (PfDHFR), a historical target for antimalarials, has been considered compromised due to resistance inducing mutations caused by pyrimethamine (PYR) overexposure. The clinical candidate P218has demonstrated that inhibitors could efficiently target both PYR-sensitive and PYR-resistant parasites through careful drug design. Yet, P218clinical development has been limited by its pharmacokinetic profile, incompatible with single dose regimen. Herein, we report the design of new PfDHFR inhibitors using fragment-based design, aiming at improved lipophilicity and overall drug-like properties. Fragment-based screening identified hits binding in the pABA site of the enzyme. Using structure-guided design, hits were elaborated into leads by fragment linking with 2,4-diaminopyrimidine. Resulting compounds display nM range inhibition of both drug-sensitive and resistant PfDHFR, high selectivity against the human isoform, drug-like lipophilicity and metabolic stability. Compound 4and its ester derivative 3kill blood stage TM4/8.2 parasite at nM concentrations while showing no toxicity against Vero cells.
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- 2023
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16. Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
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Hoarau, Marie, primary, Vanichtanankul, Jarunee, additional, Srimongkolpithak, Nitipol, additional, Vitsupakorn, Danoo, additional, Yuthavong, Yongyuth, additional, and Kamchonwongpaisan, Sumalee, additional
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- 2021
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17. Appropriation de la démarche d'analyse de l'activité par les ingénieurs pédagogiques et effets sur la conception de formations
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Challah, Rana, HOARAU, Marie, Lameul, Geneviève, Centre de Recherche sur l'Education, les apprentissages et la didactique (CREAD EA 3875), Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), and CRIFPE
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[SHS.EDU]Humanities and Social Sciences/Education ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
18. Dialectique activité & développement dans la conception de situation-problème en formation
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Hoarau, Marie, Villeret, Olivier, Munoz, Gregory, Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en éducation de Nantes (CREN), Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM), Centre de recherche interuniversitaire sur la formation et la profession enseignante, Le Mans Université (UM)-Université de Nantes - UFR Lettres et Langages (UFRLL), and Université de Nantes (UN)-Université de Nantes (UN)
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[SHS.EDU]Humanities and Social Sciences/Education ,formation ,conceptualisation ,problématisation ,développement ,Conception ,[SHS]Humanities and Social Sciences - Abstract
International audience; Si l’on peut apprendre par les situations, vécues ou simulées, en faisant ou en analysant, pendant ou après l’action, on apprend également en concevant. D’où l’idée d’un dispositif de formation, conçu comme un objet technique multifonctionnel (Simondon, 1958), qui mêle ces dimensions. Adoptant une visée didactique professionnelle (Pastré, 2011), nous mobilisons deux études de cas pour analyser la place de la conception pour développer la conceptualisation en formation. Dans deux contextes professionnels différents (professeurs de musique et tuteurs-podologues), nous recourrons au même dispositif didactique visant à initier les acteurs à la problématisation (Fabre, 2011) : 1) construire une situation-problème, 2) la mettre en œuvre, 3) en faire l’analyse, par un retour réflexif à partir d’observations basées sur des traces (vidéo ou audio) d’activité. Ce dispositif didactique constitue une « situation potentielle de développement » (Mayen, 1999) d’une pédagogie construite en acte, constituant respectivement des formes potentielles d’apprentissage « avant, pendant et après » selon Pastré (2011). Nos principaux résultats montrent que si les apprenants parviennent dans les deux cas à concevoir des situations-problèmes; en revanche, ils ont du mal à concevoir un système d’analyse et, quand c’est le cas, après moult négociations avec les formateurs-chercheurs, ils ont tendance à le faire pour évaluer plus que pour comprendre
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- 2019
19. Soutenir les transformations des pratiques à travers le prise du Design-Based Research. Les journées d'étude AIPU section France : la notion de posture pour éclairer le développement pédagogique
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Challah, Rana, HOARAU, Marie, Lameul, Geneviève, Centre de Recherche sur l'Education, les apprentissages et la didactique (CREAD EA 3875), Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), and CRIFPE
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[SHS.EDU]Humanities and Social Sciences/Education ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
20. Analysing activities of pedagogical engineers in unusual situations of distance work to design trainings
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HOARAU, Marie, Lameul, Geneviève, Centre de Recherche sur l'Education, les apprentissages et la didactique (CREAD EA 3875), Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), EARLI SIG 14, L. Roche, F. Meyer, and C. Rolland
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[SHS.EDU]Humanities and Social Sciences/Education ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2018
21. Probing Metal Ion Discrimination in a Protein Designed to Bind Uranyl Cation With Femtomolar Affinity
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Hoarau, Marie, primary, Koebke, Karl J., additional, Chen, Zhan, additional, and Marsh, E. Neil G., additional
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- 2019
- Full Text
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22. Analyse de l'activité d'enseignants-chercheurs en situations d'enseignement médiatisées par le numérique - rapport d'activité du projet QUALIFORNUM
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Hoarau, Marie, Lameul, Geneviève, Eneau, Jérôme, Centre de Recherche sur l'Education, les apprentissages et la didactique (CREAD EA 3875), Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Université de Rennes 2, CREAD, and Université Bretagne Loire
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[SHS.EDU]Humanities and Social Sciences/Education ,[SHS.PSY]Humanities and Social Sciences/Psychology - Published
- 2018
23. Correction: A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides
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Hoarau, Marie, primary, Malbert, Yannick, additional, Irague, Romain, additional, Hureau, Christelle, additional, Faller, Peter, additional, Gras, Emmanuel, additional, André, Isabelle, additional, and Remaud-Siméon, Magali, additional
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- 2018
- Full Text
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24. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
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Bowman, Pamela, primary, Sulen, Åsta, additional, Barbetti, Fabrizio, additional, Beltrand, Jacques, additional, Svalastoga, Pernille, additional, Codner, Ethel, additional, Tessmann, Ellen H, additional, Juliusson, Petur B, additional, Skrivarhaug, Torild, additional, Pearson, Ewan R, additional, Flanagan, Sarah E, additional, Babiker, Tarig, additional, Thomas, Nicholas J, additional, Shepherd, Maggie H, additional, Ellard, Sian, additional, Klimes, Iwar, additional, Szopa, Magdalena, additional, Polak, Michel, additional, Iafusco, Dario, additional, Hattersley, Andrew T, additional, Njølstad, Pål R, additional, Aisenberg, Javier, additional, Akkurt, Ilker, additional, Abdul-Latif, Hussein, additional, Al-Abdullah, Anees, additional, Barak, Lubomir, additional, Van Den Bergh, Joop, additional, Bertrand, Anne-Marie, additional, Bizzarri, Carla, additional, Bonfanti, Riccardo, additional, Bruel, Henri, additional, Burrows, Anthony, additional, Cadario, Francesco, additional, Cameron, Fergus J., additional, Carson, Dennis, additional, Cartigny, Maryse, additional, Cauvin, Vittoria, additional, Cave, Helene, additional, Chakera, Ali, additional, Chetan, Ravi, additional, Chiari, Giovanni, additional, Couch, Bob, additional, Coutant, Régis, additional, Cummings, Elizabeth, additional, Dankovcikova, Adriana, additional, Davis, Liz, additional, Deiss, Dorothee, additional, Delvecchio, Maurizio, additional, Faleschini, Elena, additional, Fauret, Anne-Laure, additional, Finn, Roisin, additional, Ford, Tamsin, additional, Franco, Elisa De, additional, Gallen, Bastian De, additional, Gasperíková, Daniela, additional, Guntamukkala, Padma, additional, Hakeem, Vaseem, additional, Hasegawa, Shinji, additional, Hathout, Eba H., additional, Heffernan, Emmeline, additional, Hill, David, additional, Ho, Josephine, additional, Hoarau, Marie, additional, Holl, Reinhard, additional, Hoddinott, Rebecca, additional, Houghton, Jane, additional, Howard, Neville, additional, Hughes, Natalie, additional, Hunter, Ian, additional, Høgåsen, Anne Kirsti, additional, Kuulasmaa, Helena, additional, Ioacara, Sorin, additional, Iotova, Violeta, additional, Irgens, Henrik, additional, Jaap, Alan, additional, Jones, Kenneth, additional, Kapellen, Thomas, additional, Kaufman, Ellen, additional, Klinge, Andreas, additional, Klupa, Tomasz, additional, Krishnaswamy, Ramaiyer, additional, Lafferty, Tony, additional, LeGault, Laurent, additional, Lambert, Paul, additional, Malecki, Maciej T, additional, Malievsky, Olag, additional, Mathew, Revi, additional, Mathews, Frances, additional, McVie, Robert, additional, Menzel, Ulrike, additional, Metz, Chantale, additional, Meulen, John Van Der, additional, Modgil, Gita, additional, Mul, Dick, additional, Muther, Silvia, additional, Nuboer, Roos, additional, O'Connell, Susan M., additional, O'Riordan, Stephen, additional, Palko, Miroslav, additional, Patel, Kashyap Amratlal, additional, Pesavento, Roberta, additional, Piccinno, Elvira, additional, Pillai, Janani Kumaraguru, additional, Pruhova, Stephanka, additional, Punthakee, Zubin, additional, Rabbone, Ivana, additional, Raile, Klemens, additional, Rincon, Marielisa, additional, Rose, Danette, additional, Sanchez, Janine, additional, Sandereson, Susan, additional, Saxena, Vinay, additional, Schebek, Martin, additional, Schmidt, Dorothee, additional, Shehadeh, Naim, additional, Shiels, Julian P.H., additional, Silva, Jose M. C. L, additional, Stanik, Juraj, additional, Tinklin, Tracy, additional, Tjora, Erling, additional, Tumini, Stefano, additional, Tuomi, Tiinamaija, additional, Uehara, Akiko, additional, Velde, Robert Van der, additional, Vermeulen, Guido, additional, Visser, Uma, additional, Voorhoeve, Paul, additional, Walker, Jan, additional, Weill, Jaques, additional, Weisner, Tobias, additional, Werner, Andrea, additional, Williams, Toni, additional, Woodhead, Helen, additional, and øddegård, Rønnaug, additional
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- 2018
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- View/download PDF
25. Revealing misleading schemes through operator activity analysis: A factory case study
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Hoarau, Marie, primary, Charron, Camilo, additional, and Mars, Franck, additional
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- 2018
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26. Étude de la tolérance glucidique dans la cohorte réunionnaise des patients atteints de la mucoviscidose
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Hoarau, Marie and UB -, BU Carreire
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Diabète lié à la mucoviscidose ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Diabète ,Mucoviscidose ,Intolérance glucidique ,Ile de la Réunion - Abstract
Objective: Reunion Island, a French overseas territory of 852,000 inhabitants, has a higher prevalence of cystic fibrosis than French national prevalence, with specific genetic characteristics. The objective was to describe a cohort of patients with cystic fibrosis, in Reunion Island, in terms of their glucose tolerance disorders.Methods : an observational, retrospective study included exhaustively patients with cystic fibrosis disease managed in 2 reference centers, in Reunion Island, between September 2016 and March 2017. Their glucose tolerance profile was determined by using their Oral Glucose Tolerance Test (OGTT). Results: 117 patients were included, including 52 women, aged 0-56 years (mean age 14.59 years). The prevalence of cystic fibrosis is estimated at 13.73 per 100,000 people. 20 patients (17.1%) have cystic fibrosis-related diabetes, 33 (28.2%) have impaired glucose tolerance (IGT), 28 (23.9%) had normal glucose tolerance (NGT), 34% of those over 18 years are were patients with diabetes. Y122X is a mutation of class 1 specific to the island, 43 patients (36.75%) were carriers of that mutation. There was no relationship between the mutation Y122X and glucose tolerance. There was no relationship between of Y122X on carbohydrate tolerance. 36 patients (30.8%) did not had an OGTT because of their young age. The mean age at diagnosis of diabetes was 18.3 years [9.2-34.9], 9 patients with diabetes were on insulin injection and 3 were on hypoglycaemic sulfonamide. None of the 33 patients, with impaired glucose tolerance, were on insulin or hypoglycaemic sulfonamide. Some patients received continuous glucose monitoring for diagnostic and therapeutic purposes. Conclusion: the prevalence of cystic fibrosis-related diabete, in Reunion Island, was close to the French national prevalence, despite having a genetic specific population. The use of new technologies in diabetes opens new perspectives., Introduction : les troubles de la tolérance glucidique sont une des complications les plus fréquentes de la mucoviscidose. Ils augmentent avec l’espérance de vie des patients. Ils altèrent l’état nutritionnel et la fonction respiratoire des patients, augmentent la mortalité. A l’île de la Réunion, la mucoviscidose a une prévalence plus importante que la prévalence nationale, avec des spécificités génétiques. Objectif : décrire la cohorte de patients porteurs d’une mucoviscidose à la Réunion sur le plan des troubles de la tolérance glucidique. Méthode : une étude observationnelle, rétrospective a inclus exhaustivement les patients suivis pour mucoviscidose dans les 2 centres de référence de la Réunion entre septembre 2016 et mars 2017. Leur statut glycémique a été déterminé à partir de leurs hyperglycémies provoquée per os (HGPO). Résultats : 117 patients ont été inclus, dont 52 femmes, âgés de 0 à 56 ans (âge moyen 14.59 ans). La prévalence de la mucoviscidose est estimée à 13.73 pour 100 000 personnes. 20 patients (17.1%) présentent un diabète lié à la mucoviscidose, 33 (28.2%) une intolérance glucidique, 28 (23.9%) sont normotolérants. 34% des plus de 18 ans sont diabétiques. Y122X est une mutation de classe 1 spécifiquement réunionnaise,43 patients (36.75%) en sont porteurs. Il n’a pas été retrouvé d’influence de Y122X sur la tolérance glucidique. 36 patients (30.8%) n’ont pas bénéficié d’HGPO du fait de leur jeune âge. L’âge moyen au diagnostic de diabète était de 18.3ans [9.2-34.9]. 9 patients diabétiques recevaient de l’insuline, 3 des sulfamides. Aucun des 33 intolérants ne recevaient d’insuline ou de sulfamides. Quelques patients ont bénéficié d’un enregistrement continu de la glycémie à visée diagnostique ou thérapeutique. Conclusion : la prévalence du diabète liée à la mucoviscidose à la Réunion est proche de la prévalence nationale malgré une génétique spécifique. L’utilisation des nouvelles technologies en diabétologie ouvre de nouvelles perspectives.
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- 2017
27. Presence of a misleading scheme in an aeronautics workshop: occurrence and remediation
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HOARAU, Marie, Perception, Action, Cognition pour la Conception et l’Ergonomie (PACCE), Laboratoire des Sciences du Numérique de Nantes (LS2N), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Unversité de Rennes 2, Camilo Charron, Franck Mars, Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (ECN)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (ECN)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
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misleading schemes ,activity analysis ,Cognitive control ,[SCCO.PSYC]Cognitive science/Psychology ,Contrôle cognitif ,Analyse de l’activité ,Schème trompeur ,[SHS.PSY]Humanities and Social Sciences/Psychology ,Dynamic situations ,Situations dynamiques ,conception d’interface écologique ,Ecological Interface Design - Abstract
The evolution of technology and the shift in the role devoted to operators in industry, from simple task execution to complex system control, provoke a development of the literature concerning assistance to fabrication process. This thesis of psychology joins this literature. It aims at designing an assistant to fabrication process, called the virtual companion, which would both support performances and maintain or improve competences. In particular, the virtual companion would be addressed to operators in an aeronautical factory. The case study requires in line simulation of dynamic physical processes. Two fields of the literature were used: frameworks concerning interface design for dynamic situations and those concerning competences. A three-parts methodology was used: (1) activity analysis of the operators in the real factory, (2) conception and validation of a microworld, and (3) design and test of a virtual companion in the microworld. Results show that the operators of the factory use a misleading scheme during their activity. This misleading scheme is also used by random participants. Moreover, this misleading scheme has an effect on the performances of random participants trained in the microworld. Finally, the virtual companion, whose interface is design based on EID principles, does not eliminate the misleading scheme. However, the participants who did not use the misleading scheme performed better after using the virtual companion. This results leads to the conclusion that studying the operators’ use of misleading schemes seems accurate as such schemes may impair the use of interfaces designed to support their activity.; L’évolution des technologies et la mutation du rôle attribué aux opérateurs de l’industrie suscitent un essor de la littérature concernant l’assistance aux procédés de fabrication. Cette thèse de psychologie s’inscrit dans cette littérature. Son objectif est de concevoir un assistant de contrôle aux procédés de fabrication, le compagnon virtuel, qui permette de maintenir à la fois les performances et les compétences des opérateurs. Le système étudié, une usine aéronautique, nécessite le recours à la simulation de processus physiques dynamiques. Deux champs de la littérature sont mobilisés : les cadres théoriques autour de la conception d’interfaces pour les environnements dynamiques et ceux sur le développement des compétences. Une méthodologie en trois parties est utilisée : (1) analyse de l’activité des opérateurs dans l’atelier réel, (2) validation d’un micromonde et (3) test d’un compagnon virtuel dans le micromonde. Les résultats montrent que les opérateurs de l’atelier réel mobilisent un schème trompeur lors de leur activité. Ce schème trompeur est également présent chez des participants tout-venants et il a un effet sur les performances des participants entrainés dans le micromonde. Enfin, le compagnon virtuel, conçu selon les principes de l’EID, ne permet pas de faire disparaitre le schème trompeur. Cependant, il permet aux participants qui n’utilisent pas le schème trompeur d’obtenir de bonnes performances. Les résultats obtenus étayent l’idée qu’il est pertinent de vérifier si des opérateurs ne mobilisent pas des schèmes trompeurs qui pourraient être un frein à l’utilisation des interfaces proposées pour les assister.
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- 2016
28. Immobilized enzymes: understanding enzyme – surface interactions at the molecular level
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Hoarau, Marie, primary, Badieyan, Somayesadat, additional, and Marsh, E. Neil G., additional
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- 2017
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29. Towards new bioinorganic hybrid catalysts based on amyloid fibres
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Hoarau, Marie and Hoarau, Marie
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Le développement d'alternatives durables aux catalyseurs actuels est un sujet clé de la chimie verte. Parmi les différentes approches proposées, l'élaboration de métalloenzymes artificielles permet de combiner l'efficacité des enzymes avec la versatilité des catalyseurs chimiques. Dans ce contexte, nous nous sommes intéressés à l'élaboration de nouveaux catalyseurs hybrides bio- inorganiques, préparés par incorporation de complexes métalliques dans les fibres amyloïdes. Ces agrégats de protéines démontrent des propriétés mécaniques exceptionnelles en biologie, qui en font des candidats de choix pour une application en catalyse. Une première partie de ce travail a consisté à surexprimer les peptides β-amyloïdes dans Escherichia coli. Une nouvelle méthode de purification des peptides a ensuite été établie permettant d'obtenir des échantillons de haute qualité en seulement quelques étapes. Une série de ligands organiques a également été synthétisée, ainsi que les complexes de Cu(II), Fe(II) et Ru(II) correspondants. L'interaction entre ces complexes et les fibres amyloïdes a été évaluée à l'aide de différentes techniques (UV-Visible, fluorescence, RMN...) et étudiée par modélisation moléculaire pour donner accès à de nouvelles informations concernant les sites potentiels d'interaction. Enfin, des études de catalyse ont été menées sur les complexes de Fe(II), démontrant des conversions élevées pour la réaction d'oxydation du styrène. Des résultats préliminaires sur les systèmes hybrides montrent que cette activité est maintenue en présence de fibres, validant le concept de catalyseurs hybrides préparés à partir de fibres amyloïdes., Developing sustainable alternatives to catalytic systems developed to date is a key point of the Green Chemistry Principles. Among the different existing approaches, the artificial metalloenzyme strategy aims at combining the efficiency of enzymes with the versatility of chemical catalysts. In this context, we turned our interest in developing a new type of bioinorganic hybrid catalysts through incorporation of coordination complexes in amyloid fibres. These protein aggregates display unique mechanical properties that make them good candidates for applications in catalysis. In a first part, our work consisted in overexpressing amyloid-βpeptides in Escherichia coli. A new purification procedure was set up that allowed to obtain peptides in a few steps. A series of organic ligands was synthesized, as well as the corresponding Cu(II), Fe(II) and Ru(II) complexes. The interaction between amyloid fibres and metal complexes was assessed, using a set of techniques (UV-Visible, Fluorescence, NMR...). Docking studies were also conducted by molecular modelling to acquire further insights in the interaction. Finally, catalytic experiments were performed with Fe(II) complexes, showing high conversion rates for styrene oxidation reaction. Preliminary results on the final hybrid systems show that the catalytic activity of metal complexes is maintained upon incorporation within fibres. This constitutes a proof of concept for the elaboration of hybrid catalysts based on amyloid fibres.
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- 2016
30. A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides
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Hoarau, Marie, primary, Malbert, Yannick, additional, Irague, Romain, additional, Hureau, Christelle, additional, Faller, Peter, additional, Gras, Emmanuel, additional, André, Isabelle, additional, and Remaud-Siméon, Magali, additional
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- 2016
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31. Where do misleading schemes of operators in industry come from?
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Hoarau, Marie, primary, Charron, Camilo, additional, and Mars, Franck, additional
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- 2016
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32. Activity Analysis of Expert and Novice Operators in a Semi-Automated Manufacturing Process
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Hoarau, Marie, primary, Charron, Camilo, additional, and Mars, Franck, additional
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- 2014
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33. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11mutations: an international cohort study
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Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, Njølstad, Pål R, Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, and øddegård, Rønnaug
- Abstract
KCNJ11mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type 2 diabetes after 5 years of treatment. Therefore, we did a 10-year multicentre follow-up study of a large international cohort of patients with KCNJ11permanent neonatal diabetes to address the key questions relating to long-term efficacy and safety of sulfonylureas in these patients.
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- 2018
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34. Activity Analysis of Expert and Novice Operators in a Semi-Automated Manufacturing Process.
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Hoarau, Marie, Charron, Camilo, and Mars, Franck
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- 2015
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35. Review of the Seychelles’ Nurses and Midwives Act
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Agricole, Winifred, primary, Hoarau, Marie Antoinette, additional, Suzette, Jeanne D'Arc, additional, and Sinon, Elsia, additional
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- 2014
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36. Activity Analysis of Expert and Novice Operators in a Semi-Automated Manufacturing Process.
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Hoarau, Marie, Charron, Camilo, and Mars, Franck
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- 2014
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37. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
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Bowman P., Sulen A., Barbetti F., Beltrand J., Svalastoga P., Codner E., Tessmann E. H., Juliusson P. B., Skrivarhaug T., Pearson E. R., Flanagan S. E., Babiker T., Thomas N. J., Shepherd M. H., Ellard S., Klimes I., Szopa M., Polak M., Iafusco D., Hattersley A. T., Njolstad P. R., Aisenberg J., Akkurt I., Abdul-Latif H., Al-Abdullah A., Barak L., Van Den Bergh J., Bertrand A. -M., Bizzarri C., Bonfanti R., Bruel H., Burrows A., Cadario F., Cameron F. J., Carson D., Cartigny M., Cauvin V., Cave H., Chakera A., Chetan R., Chiari G., Couch B., Coutant R., Cummings E., Dankovcikova A., Davis L., Deiss D., Delvecchio M., Faleschini E., Fauret A. -L., Finn R., Ford T., Franco E. D., Gallen B. D., Gasperikova D., Guntamukkala P., Hakeem V., Hasegawa S., Hathout E. H., Heffernan E., Hill D., Ho J., Hoarau M., Holl R., Hoddinott R., Houghton J., Howard N., Hughes N., Hunter I., Hogasen A. K., Kuulasmaa H., Ioacara S., Iotova V., Irgens H., Jaap A., Jones K., Kapellen T., Kaufman E., Klinge A., Klupa T., Krishnaswamy R., Lafferty T., LeGault L., Lambert P., Malecki M. T., Malievsky O., Mathew R., Mathews F., McVie R., Menzel U., Metz C., Meulen J. V. D., Modgil G., Mul D., Muther S., Nuboer R., O'Connell S. M., O'Riordan S., Palko M., Patel K. A., Pesavento R., Piccinno E., Pillai J. K., Pruhova S., Punthakee Z., Rabbone I., Raile K., Rincon M., Rose D., Sanchez J., Sandereson S., Saxena V., Schebek M., Schmidt D., Shehadeh N., Shiels J. P. H., Silva J. M. C. L., Stanik J., Tinklin T., Tjora E., Tumini S., Tuomi T., Uehara A., Velde R. V. D., Vermeulen G., Visser U., Voorhoeve P., Walker J., Weill J., Weisner T., Werner A., Williams T., Woodhead H., oddegard R., Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacque, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, Njølstad, Pål R, Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anee, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Denni, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régi, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Iocara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thoma, Kaufman, Ellen, Klinge, Andrea, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, Legault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, France, Mcvie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roo, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemen, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P. H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaque, Weisner, Tobia, Werner, Andrea, Williams, Toni, Woodhead, Helen, Øddegård, Rønnaug, Bowman, P., Sulen, A., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D., Hattersley, A. T., Njolstad, P. R., Aisenberg, J., Akkurt, I., Abdul-Latif, H., Al-Abdullah, A., Barak, L., Van Den Bergh, J., Bertrand, A. -M., Bizzarri, C., Bonfanti, R., Bruel, H., Burrows, A., Cadario, F., Cameron, F. J., Carson, D., Cartigny, M., Cauvin, V., Cave, H., Chakera, A., Chetan, R., Chiari, G., Couch, B., Coutant, R., Cummings, E., Dankovcikova, A., Davis, L., Deiss, D., Delvecchio, M., Faleschini, E., Fauret, A. -L., Finn, R., Ford, T., Franco, E. D., Gallen, B. D., Gasperikova, D., Guntamukkala, P., Hakeem, V., Hasegawa, S., Hathout, E. H., Heffernan, E., Hill, D., Ho, J., Hoarau, M., Holl, R., Hoddinott, R., Houghton, J., Howard, N., Hughes, N., Hunter, I., Hogasen, A. K., Kuulasmaa, H., Ioacara, S., Iotova, V., Irgens, H., Jaap, A., Jones, K., Kapellen, T., Kaufman, E., Klinge, A., Klupa, T., Krishnaswamy, R., Lafferty, T., Legault, L., Lambert, P., Malecki, M. T., Malievsky, O., Mathew, R., Mathews, F., Mcvie, R., Menzel, U., Metz, C., Meulen, J. V. D., Modgil, G., Mul, D., Muther, S., Nuboer, R., O'Connell, S. M., O'Riordan, S., Palko, M., Patel, K. A., Pesavento, R., Piccinno, E., Pillai, J. K., Pruhova, S., Punthakee, Z., Rabbone, I., Raile, K., Rincon, M., Rose, D., Sanchez, J., Sandereson, S., Saxena, V., Schebek, M., Schmidt, D., Shehadeh, N., Shiels, J. P. H., Silva, J. M. C. L., Stanik, J., Tinklin, T., Tjora, E., Tumini, S., Tuomi, T., Uehara, A., Velde, R. V. D., Vermeulen, G., Visser, U., Voorhoeve, P., Walker, J., Weill, J., Weisner, T., Werner, A., Williams, T., Woodhead, H., and Oddegard, R.
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Background: KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type 2 diabetes after 5 years of treatment. Therefore, we did a 10-year multicentre follow-up study of a large international cohort of patients with KCNJ11 permanent neonatal diabetes to address the key questions relating to long-term efficacy and safety of sulfonylureas in these patients. Methods: In this multicentre, international cohort study, all patients diagnosed with KCNJ11 permanent neonatal diabetes at five laboratories in Exeter (UK), Rome (Italy), Bergen (Norway), Paris (France), and Krakow (Poland), who transferred from insulin to oral sulfonylureas before Nov 30, 2006, were eligible for inclusion. Clinicians collected clinical characteristics and annual data relating to glycaemic control, sulfonylurea dose, severe hypoglycaemia, side-effects, diabetes complications, and growth. The main outcomes of interest were sulfonylurea failure, defined as permanent reintroduction of daily insulin, and metabolic control, specifically HbA 1c and sulfonylurea dose. Neurological features associated with KCNJ11 permanent neonatal diabetes were also assessed. This study is registered with ClinicalTrials.gov, number NCT02624817. Findings: 90 patients were identified as being eligible for inclusion and 81 were enrolled in the study and provided long-term (>5·5 years cut-off) outcome data. Median follow-up duration for the whole cohort was 10·2 years (IQR 9·3–10·8). At most recent follow-up (between Dec 1, 2012, and Oct 4, 2016), 75 (93%) of 81 participants remained on sulfonylurea therapy alone. Excellent glycaemic control was maintained for patients for whom we had paired data on HbA 1c and sulfonylurea at all time points (ie, pre-transfer [for HbA 1c ], year 1, and most recent follow-up; n=64)—median HbA 1c was 8·1% (IQR 7·2–9·2; 65·0 mmol/mol [55·2–77·1]) before transfer to sulfonylureas, 5·9% (5·4–6·5; 41·0 mmol/mol [35·5–47·5]; p
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- 2018
38. Endocrine management of transgender adolescents: Expert consensus of the french society of pediatric endocrinology and diabetology working group.
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Brezin F, Busiah K, Leroy C, Fiot E, Bensignor C, Amouroux C, Caquard M, Cartault A, Castets S, Delcour C, Devernay M, Feigerlova E, Hoarau M, Lebon-Labich B, Lambert AS, Rouleau S, Trouvin MA, Vautier V, and Martinerie L
- Abstract
Introduction: Requests for hormonal transition in minors are increasing. To date, there is no national recommendation to guide these practices in France. Therefore, the SFEDP (French Society of Pediatric Endocrinology and Diabetology) has commissioned a group of experts to draft the first national consensus on this topic., Method: Each chapter was prepared by one to three authors who conducted a literature review, and it was then reviewed and revised by the group as many times as necessary to achieve a consensus position. The final document was reviewed by a group of external experts., Results: A consensus position was reached regarding the multi-professional nature of support for trans youth, the prescription of molecules aimed at inhibiting endogenous hormone secretion, and the use of gender-affirming hormone therapies, as well as the importance of offering gamete preservation. Non-hormonal aspects of support and various considerations, including ethical ones, were also discussed., Conclusion: This work constitutes an initial set of recommendations for professionals involved in the hormonal transition of trans youth. Additional recommendations under the auspices of the French High Authority for Health would be worthy of being drafted, involving all relevant stakeholders to establish comprehensive official national guidelines that would secure the support and rights of these young individuals, especially those under 16 years old, as well as the professionals involved in their care., (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2024
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39. Novel flexible biphenyl Pf DHFR inhibitors with improved antimalarial activity.
- Author
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Decharuangsilp S, Arwon U, Sooksai N, Rattanajak R, Saeyang T, Vitsupakorn D, Vanichtanankul J, Yuthavong Y, Kamchonwongpaisan S, and Hoarau M
- Abstract
As pregnant women and young children remain the first victims of malaria worldwide, the search for new antimalarials has been focusing on compounds with a high safety profile and extended efficacy. In a previous study, a rigid biphenyl Pf DHFR inhibitor was developed by fragment-based screening, displaying sub nM enzyme inhibition but poor antiparasitic activity, presumably due to its low flexibility. Here, we report a new series of compounds that combines the biphenyl fragment with a flexible linker. Interestingly, their mode of binding differs from previously reported compounds, taking advantage of strong hydrophobic interaction. The new flexible biphenyl compounds show overall improved antiparasitic activity compared to rigid ones, with the best compound displaying a 2 nM antiplasmodial IC
50 and suitable drug-like properties. This confirms the importance of compound flexibility for antimalarial activity and opens the way to new opportunities for antimalarial drug design., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)- Published
- 2024
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