Search

Three new bis-trinorcadalenes, bistrinorcadintermes A–C (1-3) along with seven known compounds, parvifloral D (4), parvifloral E (5), parvifloral C (6), hymexelsin (7), scopoletin (8), scopolin (9), and hibiscolactone A (10) were isolated from the aerial parts and radix of Decaschistia intermedia Craib. Their chemical structures were determined based on spectroscopic methods, including 1D, 2D NMR, MS, and experimental CD spectra. All compounds were evaluated for their α-glucosidase inhibitory effects. Compounds 1, 5, and 8 showed moderate α-glucosidase inhibitory activities with IC50 values of 45.6 ± 4.2, 43.7 ± 3.6, and 43.7 ± 3.6 μg/mL, respectively. Compounds 2-4 and 10 showed weak α-glucosidase inhibitory activities with IC50 values ranging from 87.5 ± 6.3 to 219.8 ± 4.9 μg/mL.

Two new cadinane sesquiterpenes, cadinoschanes A and B (1 and 2), one new norlignan, lignanoschane A (6) along with seven known compounds, hibiscone B (3), 7β-O-β-glucopyranosyl bombaxone (4), 2,7β,8β-trihydroxy trans-calamenene 7-O-β-D-glucopyranoside (5), clemastanin A (7), (−)-3,4,3′,4′-tetrahydroxy-9,7′β-epoxylignano-7β,9′-lactone (8), N-trans-feruloyl tyramine (9), and methyl (3R)-3-[(3R)-3-{(3R)-3-hydroxybutanoyloxy} butanoyloxy} butanoate (10) were isolated from Abelmoschus moschatus subsp. tuberosus (Span.) Borss. Waalk. Their structures were determined on the basis of extensive spectroscopic methods, including 1D, 2D NMR and MS data and comparing experimental CD with theoretical CD calculations. Compounds 3 and 9 showed significant α-glucosidase inhibitory activity with IC50 values of 121.7 ± 3.9 and 4.3 ± 0.5 μg/mL, respectively, compared to those of a positive control, acarbose with IC50 value of 183.5 ± 12.2 μg/mL.

Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Korea. E-mail: bsmin@cu.ac.kr Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam Deparment of Pharmacognosy, Hanoi University of Pharmacy, 15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam Faculty of Food Science and Biotechnology, Pukyung National University, Busan 608-737, Korea College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea Received November 14, 2013, Accepted November 27, 2013

Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Korea. E-mail: bsmin@cu.ac.kr Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam Deparment of Pharmacognosy, Hanoi University of Pharmacy, 15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam Faculty of Food Science and Biotechnology, Pukyung National University, Busan 608-737, Korea College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea Received November 14, 2013, Accepted November 27, 2013

A new alkenylphenol, bavinol A (1), together with six known compounds (2–7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1–7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.