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1. Exercise capacity-hemodynamics mismatch in elderly patients with pulmonary hypertension: A nationwide multicenter study from Taiwan Society of Cardiology Pulmonary Hypertension Registry (TAIPANS)

Author

Chen, Chang-Ying, Mei-Tzu, Wang, Sung, Shih-Hsien, Wu, Yih-Jer, Hsu, Chih-Hsin, Ho, Wan-Jing, Lin, Yen-Hung, Liu, Wei-Shin, Liu, Ju-Chi, Kao, Yung-Ta, Wu, Wen-Shiann, Wu, Chun-Hsien, Lei, Meng-Huan, Chen, Yu-Wei, Chen-Yu, Chien, Chiu, Yu-Wei, Dai, Zen-Kong, Lin, Tsung-Hsien, Lin, Lin, Chung, Cheng-Chih, Chung, Chang-Min, Huang, Sung-Hao, Cheng, Chin-Chang, Wu, Yen-Wen, Chao, Ting-Hsing, Hwang, Juey-Jen, Jia-Yin Hou, Charles, and Huang, Wei-Chun

Published
2024
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2. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Louis, Renaud, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Georgopoulos, Dimitrios, Fanaridis, Michail, Mitrouska, Ioanna, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Mulè, Massimiliano, Farruggio, Silvia, Costa, Serena, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Ghofrani, Hossein-Ardeschir, Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberá, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Hoeper, Marius M.

Published
2021
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3. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Louis, Renaud, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Mitrouska, Ioanna, Georgopoulos, Dimitrios, Fanaridis, Michail, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Farruggio, Silvia, Costa, Serena, Mulè, Massimiliano, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Hoeper, Marius M., Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberà, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Ghofrani, Hossein-Ardeschir

Published
2021
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5. Long-Term Survival of Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: A Single-Center Cohort

Author

Hsieh, Yu Jui, Ho, Wan-Jing, Lin, Chia-Pin, Luo, Shue-Fen, Yu, Kuang-Hui, Chen, Ji-Yih, Hsiao, Fu-Chih, and Chang, Chieh-Yu

Subjects
Original Article
Abstract

Pulmonary arterial hypertension (PAH) is a rare but severe complication of connective tissue disease (CTD). CTD-associated PAH (CTD-PAH) is the most common subgroup of PAH in East Asia. We prospectively collected 41 patients with CTD-PAH and followed them for a mean period of 43 ± 36 months. The long-term survival rates of the CTD-PAH patients at 1, 2, 3 and 5 years were 90%, 80%, 77%, and 60%, respectively. The non-survivors had more dilated main pulmonary arteries, higher pulmonary artery pressure and pulmonary vascular resistance (PVR). PAH-specific therapy resulted in improvements in functional class, 6-minute walk distance, serum uric acid, right ventricular function and PVR. Increased C-reactive protein during follow-up, indicating inflammatory processes, was also crucial for the management of CTD-PAH. Therefore targeting both PAH and inflammation is important in this specific subgroup of PAH. The results of this study may help develop treatment strategies for CTD-PAH patients.

Published
2023

6. 2023 Taiwan Society of Cardiology (TSOC) and Taiwan College of Rheumatology (TCR) Joint Consensus on Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

Author

Huang, Wei-Chun, Hsieh, Song-Chou, Wu, Yen-Wen, Hsieh, Tsu-Yi, Wu, Yih-Jer, Li, Ko-Jen, Charng, Min-Ji, Chen, Wei-Sheng, Sung, Shih-Hsien, Tsao, Yen-Po, Ho, Wan-Jing, Lai, Chien-Chih, Cheng, Chin-Chang, Tsai, Hung-Cheng, Hsu, Chih-Hsin, Lu, Cheng-Hsun, Chiu, Yu-Wei, Shen, Chieh-Yu, Wu, Chun-Hsien, Liu, Feng-Cheng, Lin, Yen-Hung, Yeh, Fu-Chiang, Liu, Wei-Shin, Lee, Hui-Ting, Wu, Shu-Hao, Chang, Chi-Ching, Chu, Chun-Yuan, Hou, Charles Jia-Yin, and Tsai, Chang-Youh

Subjects
Consensus
Abstract

BACKGROUND: Pulmonary arterial hypertension (PAH), defined as the presence of a mean pulmonary artery pressure > 20 mmHg, pulmonary artery wedge pressure ≤ 15 mmHg, and pulmonary vascular resistance (PVR) > 2 Wood units based on expert consensus, is characterized by a progressive and sustained increase in PVR, which may lead to right heart failure and death. PAH is a well-known complication of connective tissue diseases (CTDs), such as systemic sclerosis, systemic lupus erythematosus, Sjogren’s syndrome, and other autoimmune conditions. In the past few years, tremendous progress in the understanding of PAH pathogenesis has been made, with various novel diagnostic and screening methods for the early detection of PAH proposed worldwide. OBJECTIVES: This study aimed to obtain a comprehensive understanding and provide recommendations for the management of CTD-PAH in Taiwan, focusing on its clinical importance, prognosis, risk stratification, diagnostic and screening algorithm, and pharmacological treatment. METHODS: The members of the Taiwan Society of Cardiology (TSOC) and Taiwan College of Rheumatology (TCR) reviewed the related literature thoroughly and integrated clinical trial evidence and real-world clinical experience for the development of this consensus. CONCLUSIONS: Early detection by regularly screening at-risk patients with incorporations of relevant autoantibodies and biomarkers may lead to better outcomes of CTD-PAH. This consensus proposed specific screening flowcharts for different types of CTDs, the risk assessment tools applicable to the clinical scenario in Taiwan, and a recommendation of medications in the management of CTD-PAH.

Published
2023

10. Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study

Author

Huang, Yueh-Hsiang, primary, Wu, Yi-Hong, additional, Tang, Hsiang-Yu, additional, Chen, Szu-Tah, additional, Wang, Chih-Ching, additional, Ho, Wan-Jing, additional, Lin, Yi-Hsuan, additional, Liu, Geng-Hao, additional, Lin, Pei-Yeh, additional, Lo, Chi-Jen, additional, Yeh, Yuan-Ming, additional, and Cheng, Mei-Ling, additional

Published
2022
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12. Quality of Life in Patients With Pulmonary Hypertension.

Author

Shang, Shu-Ting, Chang, Yu-Ling, Ho, Wan-Jing, Liu, Chieh-Yu, and Chien, Ching-Hui

Subjects
STATISTICS, AFFECT (Psychology), SOCIAL support, PULMONARY hypertension, CROSS-sectional method, ONE-way analysis of variance, MULTIVARIATE analysis, HEALTH surveys, REGRESSION analysis, QUALITY of life, QUESTIONNAIRES, CHI-squared test, STATISTICAL sampling, DATA analysis software
Abstract

We explored positive and negative affect, quality of life (QOL), and associated factors in patients with pulmonary hypertension. We conducted this cross-sectional study using convenience sampling at a medical center in Taiwan. We used the Social Support Scale, positive and negative affect scale, and Short Form 36-item Health Survey to collect data. In these patients, greater social support was associated with less negative affect and better QOL (mental components). Lower Borg dyspnea scores or greater distances in the six-minute walk test were associated with more positive affect, less negative affect, and better QOL (both physical and mental components). Patients with less negative affect and more positive affect had better QOL (mental components). Therefore, nursing staff should routinely monitor the emotional status and QOL of patients with pulmonary hypertension, especially those with less social support and poorer cardiopulmonary function. Strengthening these aspects may improve patients' emotional status and QOL. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Ghofrani, Hossein-Ardeschir, primary, Gomez Sanchez, Miguel-Angel, additional, Humbert, Marc, additional, Pittrow, David, additional, Simonneau, Gérald, additional, Gall, Henning, additional, Grünig, Ekkehard, additional, Klose, Hans, additional, Halank, Michael, additional, Langleben, David, additional, Snijder, Repke J., additional, Escribano Subias, Pilar, additional, Mielniczuk, Lisa M., additional, Lange, Tobias J., additional, Vachiéry, Jean-Luc, additional, Wirtz, Hubert, additional, Helmersen, Douglas S., additional, Tsangaris, Iraklis, additional, Barberá, Joan A., additional, Pepke-Zaba, Joanna, additional, Boonstra, Anco, additional, Rosenkranz, Stephan, additional, Ulrich, Silvia, additional, Steringer-Mascherbauer, Regina, additional, Delcroix, Marion, additional, Jansa, Pavel, additional, Šimková, Iveta, additional, Giannakoulas, George, additional, Klotsche, Jens, additional, Williams, Evgenia, additional, Meier, Christian, additional, Hoeper, Marius M., additional, Caneva, Jorge, additional, Tuhay, Graciela, additional, Diez, Mirta, additional, Talavera, Maria Lujan, additional, Acosta, Adriana, additional, Vulcano, Norberto, additional, Bosio, Martin, additional, Maldonado, Lorena, additional, Deleo, Sabino, additional, Melatini, Luciano, additional, Keogh, Anne, additional, Kotlyar, Eugene, additional, Feenstra, John, additional, Dwyer, Nathan, additional, Adams, Heath, additional, Stevens, Wendy, additional, Steele, Peter, additional, Proudman, Susanna, additional, Minson, Robert, additional, Reeves, Glenn, additional, Lavender, Melanie, additional, Ng, Benjamin, additional, Mackenzie, Michele, additional, Barry, Lisa, additional, Gruenberger, Margarethe, additional, Huber, Charlotte, additional, Lang, Irene, additional, Tilea, Ioana, additional, Sadushi-Kolici, Roela, additional, Löffler-Ragg, Judith, additional, Feistmantl, Lisa-Theresa, additional, Evrard, Patrick, additional, Louis, Renaud, additional, Guiot, Julien, additional, Naldi, Marco, additional, De Pauw, Michel, additional, Mehta, Sanjay, additional, Camacho, Rafael Conde, additional, Tovar, Patricia Parada, additional, Londoño, Alejandro, additional, Campo, Felipe, additional, Garcia, Paula, additional, Lema, Camila, additional, Orozco-Levi, Mauricio, additional, Martinez, William, additional, Gomez, Juan Esteban, additional, Nielsen-Kudsk, Jens Erik, additional, Mellemkjaer, Soren, additional, Anton, Ly, additional, Altraja, Alan, additional, Vihinen, Tapani, additional, Vasankari, Tuija, additional, Sitbon, Olivier, additional, Cottin, Vincent, additional, Têtu, Laurent, additional, Noël-Savina, Elise, additional, Shearman, Nicole, additional, Tayler, Susanne, additional, Olzik, Ilona, additional, Kulka, Christine, additional, Grimminger, Jan, additional, Simon, Marcel, additional, Nolde, Anna, additional, Oqueka, Tim, additional, Harbaum, Lars, additional, Egenlauf, Benjamin, additional, Ewert, Ralf, additional, Schulz, Christian, additional, Regotta, Sabine, additional, Kramer, Tilmann, additional, Knoop-Busch, Susanne, additional, Gerhardt, Felix, additional, Konstantinides, Stavros, additional, Pitsiou, Georgia, additional, Stanopoulos, Ioannis, additional, Sourla, Evdokia, additional, Mouratoglou, Sofia, additional, Karvounis, Haralambos, additional, Pappas, Athanasios, additional, Georgopoulos, Dimitrios, additional, Fanaridis, Michail, additional, Mitrouska, Ioanna, additional, Michalis, Lampros, additional, Pappas, Konstantinos, additional, Kotsia, Anna, additional, Gaine, Sean, additional, Vizza, Carmine Dario, additional, Manzi, Giovanna, additional, Poscia, Roberto, additional, Badagliacca, Roberto, additional, Agostoni, Piergiuseppe, additional, Bruno, Noemi, additional, Farina, Stefania, additional, D'Alto, Michele, additional, Argiento, Paola, additional, Correra, Anna, additional, Di Marco, Giovanni Maria, additional, Cresci, Chiara, additional, Vannucchi, Vieri, additional, Torricelli, Elena, additional, Garcea, Alessio, additional, Pesci, Alberto, additional, Sardella, Luca, additional, Paciocco, Giuseppe, additional, Pane, Federico, additional, D'Armini, Andrea Maria, additional, Pin, Maurizio, additional, Grazioli, Valentina, additional, Massola, Giulia, additional, Sciortino, Antonio, additional, Prediletto, Renato, additional, Bauleo, Carolina, additional, Airò, Edoardo, additional, Ndreu, Rudina, additional, Pavlickova, Ivana, additional, Lunardi, Claudio, additional, Mulè, Massimiliano, additional, Farruggio, Silvia, additional, Costa, Serena, additional, Galgano, Giuseppe, additional, Petruzzi, Mario, additional, De Luca, Anna, additional, Lombardi, Francesco, additional, Roncon, Loris, additional, Conte, Luca, additional, Picariello, Claudio, additional, Wirtz, Gil, additional, Alexandre, Myriam, additional, Vonk-Noordegraaf, A., additional, Boogaard, H., additional, Mager, J., additional, Reesink, H., additional, van den Toorn, Leon M., additional, Boomars, Karin, additional, Andreassen, Arne K., additional, Castro, Graça, additional, Tania, Gonçalves, additional, Baptista, Rui, additional, Marinho, António, additional, Shiang, Teresa, additional, Oliveira, Ana, additional, Coutinho, Daniel, additional, Sousa, Joana, additional, Loureiro, Maria José, additional, Repolho, Débora, additional, Martins Jesus, Susana Maria, additional, Capinha, Marta, additional, Agostinho, João, additional, Cardoso, Tania, additional, Rocha, Andreia, additional, Espinha, Mafalda, additional, Ivanov, Kyundyul Ivanovich, additional, Alexeeva, Dalyana Eduardovna, additional, Batalina, Marina Vadimovna, additional, Hegya, Daria Viktorovna, additional, Zvereva, Tatyana Nikolaevna, additional, Avdeev, Sergey Nikolaevich, additional, Tsareva, Natalia Anatolievna, additional, Galyavich, Albert Sarvatovich, additional, Nikolaevich, Bykov Aleksander, additional, Filippov, Evgeny Vladimirovich, additional, Yakovleva, Olga Eduardovna, additional, Pavlova, Olga Borisovna, additional, Skripkina, Elena Sergeevna, additional, Martynyuk, Tamila Vitalievna, additional, Bukatova, Irina Fedorovna, additional, Tregubova, Anna Viktorovna, additional, Platonov, Dmitry Yurievich, additional, Kolomeytseva, Tatyana Mikhaylovna, additional, Al Dalaan, Abdullah, additional, Abdelsayed, Abeer Abeer, additional, Weheba, Ihab, additional, Saleemi, Sarferaz, additional, Sakkijha, Hussam, additional, Bohacekova, Marcela, additional, Valkovicova, Tatiana, additional, Farkasova, Iveta, additional, Quezada, Carlos Andres, additional, Piccari, Lucilla, additional, Blanco, Isabel, additional, Sebastian, Laura, additional, Roman, Antonio, additional, Lopez, Manuel, additional, Otero, Remedios, additional, Elias, Teresa, additional, Jara, Luis, additional, Asencio, Isabel, additional, Arjona, Josefa Jiménez, additional, Almagro, Raúl Menor, additional, Cárdenas, Salvador López, additional, García, Salvador Alcaraz, additional, Rodríguez, Patricia Villanueva, additional, Lopez, Raquel, additional, Garcia, Alberto, additional, Avilés, Francisco Fernandez, additional, De La Pava, Sebastian, additional, Yotti, Raquel, additional, Peñate, Gregorio Pérez, additional, Marrero, Fernando León, additional, Cifrián Martínez, José Manuel, additional, Martinez-Meñaca, Amaya, additional, Alonso, Lecue Pilar, additional, Rozas, Sonia Fernandez, additional, Fernandez, David Iturbe, additional, Cuesta, Victor Mora, additional, Söderberg, Stefan, additional, Bartfay, Sven-Erik, additional, Rundqvist, Bengt, additional, Alfetlawi, Monthir, additional, Wodlin, Peter, additional, Schwarz, Esther Irene, additional, Speich, Rudolf, additional, Lador, Frédéric, additional, Rochat, Thierry, additional, Gasche-Soccal, Paola, additional, Hsu, Chih-Hsin, additional, Lin, Tsung-Hsien, additional, Su, Ho-Ming, additional, Lai, Wen-Ter, additional, Chu, Chun Yuan, additional, Hsu, Po-Chao, additional, Voon, Wen-Chol, additional, Yen, Hsueh-Wei, additional, Yih-Jer Wu, Jacob, additional, Wu, Shu-Hao, additional, Huang, Wen-Pin, additional, Fong, Man-Cai, additional, Huang, Chien-Lung, additional, Kuo, Ping-Hung, additional, Lin, Yen-Hung, additional, Lin, Jiunn-Lee, additional, Hung, Chi-Sheng, additional, Wu, Cho-Kai, additional, Sung, Shih-Hsien, additional, Huang, Wei-Chun, additional, Cheng, Chin-Chang, additional, Kuo, Shu-Hung, additional, Wang, Wen-Hwa, additional, Ho, Wan-Jing, additional, Hsu, Tsu-Shiu, additional, Mutlu, Bülent, additional, Atas, Halil, additional, Ongen, Gul, additional, Un, Zeynep, additional, Okumus, Gulfer, additional, Hanta, Ismail, additional, Corris, Paul, additional, Peacock, Andrew, additional, Church, Colin, additional, Toshner, Mark, additional, and Newnham, Michael, additional

Published
2021
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18. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Hoeper, Marius M., primary, Gomez Sanchez, Miguel-Angel, additional, Humbert, Marc, additional, Pittrow, David, additional, Simonneau, Gérald, additional, Gall, Henning, additional, Grünig, Ekkehard, additional, Klose, Hans, additional, Halank, Michael, additional, Langleben, David, additional, Snijder, Repke J., additional, Escribano Subias, Pilar, additional, Mielniczuk, Lisa M., additional, Lange, Tobias J., additional, Vachiéry, Jean-Luc, additional, Wirtz, Hubert, additional, Helmersen, Douglas S., additional, Tsangaris, Iraklis, additional, Barberà, Joan A., additional, Pepke-Zaba, Joanna, additional, Boonstra, Anco, additional, Rosenkranz, Stephan, additional, Ulrich, Silvia, additional, Steringer-Mascherbauer, Regina, additional, Delcroix, Marion, additional, Jansa, Pavel, additional, Šimková, Iveta, additional, Giannakoulas, George, additional, Klotsche, Jens, additional, Williams, Evgenia, additional, Meier, Christian, additional, Ghofrani, Hossein-Ardeschir, additional, Caneva, Jorge, additional, Tuhay, Graciela, additional, Diez, Mirta, additional, Talavera, Maria Lujan, additional, Acosta, Adriana, additional, Vulcano, Norberto, additional, Bosio, Martin, additional, Maldonado, Lorena, additional, Deleo, Sabino, additional, Melatini, Luciano, additional, Keogh, Anne, additional, Kotlyar, Eugene, additional, Feenstra, John, additional, Dwyer, Nathan, additional, Adams, Heath, additional, Stevens, Wendy, additional, Steele, Peter, additional, Proudman, Susanna, additional, Minson, Robert, additional, Reeves, Glenn, additional, Lavender, Melanie, additional, Ng, Benjamin, additional, Mackenzie, Michele, additional, Barry, Lisa, additional, Gruenberger, Margarethe, additional, Huber, Charlotte, additional, Lang, Irene, additional, Tilea, Ioana, additional, Sadushi-Kolici, Roela, additional, Löffler-Ragg, Judith, additional, Feistmantl, Lisa-Theresa, additional, Evrard, Patrick, additional, Guiot, Julien, additional, Naldi, Marco, additional, De Pauw, Michel, additional, Louis, Renaud, additional, Mehta, Sanjay, additional, Camacho, Rafael Conde, additional, Tovar, Patricia Parada, additional, Londoño, Alejandro, additional, Campo, Felipe, additional, Garcia, Paula, additional, Lema, Camila, additional, Orozco-Levi, Mauricio, additional, Martinez, William, additional, Gomez, Juan Esteban, additional, Nielsen-Kudsk, Jens Erik, additional, Mellemkjaer, Soren, additional, Anton, Ly, additional, Altraja, Alan, additional, Vihinen, Tapani, additional, Vasankari, Tuija, additional, Sitbon, Olivier, additional, Cottin, Vincent, additional, Têtu, Laurent, additional, Noël-Savina, Elise, additional, Shearman, Nicole, additional, Tayler, Susanne, additional, Olzik, Ilona, additional, Kulka, Christine, additional, Grimminger, Jan, additional, Simon, Marcel, additional, Nolde, Anna, additional, Oqueka, Tim, additional, Harbaum, Lars, additional, Egenlauf, Benjamin, additional, Ewert, Ralf, additional, Schulz, Christian, additional, Regotta, Sabine, additional, Kramer, Tilmann, additional, Knoop-Busch, Susanne, additional, Gerhardt, Felix, additional, Konstantinides, Stavros, additional, Pitsiou, Georgia, additional, Stanopoulos, Ioannis, additional, Sourla, Evdokia, additional, Mouratoglou, Sofia, additional, Karvounis, Haralambos, additional, Pappas, Athanasios, additional, Mitrouska, Ioanna, additional, Georgopoulos, Dimitrios, additional, Fanaridis, Michail, additional, Michalis, Lampros, additional, Pappas, Konstantinos, additional, Kotsia, Anna, additional, Gaine, Sean, additional, Vizza, Carmine Dario, additional, Manzi, Giovanna, additional, Poscia, Roberto, additional, Badagliacca, Roberto, additional, Agostoni, Piergiuseppe, additional, Bruno, Noemi, additional, Farina, Stefania, additional, D'Alto, Michele, additional, Argiento, Paola, additional, Correra, Anna, additional, Di Marco, Giovanni Maria, additional, Cresci, Chiara, additional, Vannucchi, Vieri, additional, Torricelli, Elena, additional, Garcea, Alessio, additional, Pesci, Alberto, additional, Sardella, Luca, additional, Paciocco, Giuseppe, additional, Pane, Federico, additional, D'Armini, Andrea Maria, additional, Pin, Maurizio, additional, Grazioli, Valentina, additional, Massola, Giulia, additional, Sciortino, Antonio, additional, Prediletto, Renato, additional, Bauleo, Carolina, additional, Airò, Edoardo, additional, Ndreu, Rudina, additional, Pavlickova, Ivana, additional, Lunardi, Claudio, additional, Farruggio, Silvia, additional, Costa, Serena, additional, Mulè, Massimiliano, additional, Galgano, Giuseppe, additional, Petruzzi, Mario, additional, De Luca, Anna, additional, Lombardi, Francesco, additional, Roncon, Loris, additional, Conte, Luca, additional, Picariello, Claudio, additional, Wirtz, Gil, additional, Alexandre, Myriam, additional, Vonk-Noordegraaf, A., additional, Boogaard, H., additional, Mager, J., additional, Reesink, H., additional, van den Toorn, Leon M., additional, Boomars, Karin, additional, Andreassen, Arne K., additional, Castro, Graça, additional, Tania, Gonçalves, additional, Baptista, Rui, additional, Marinho, António, additional, Shiang, Teresa, additional, Oliveira, Ana, additional, Coutinho, Daniel, additional, Sousa, Joana, additional, Loureiro, Maria José, additional, Repolho, Débora, additional, Martins Jesus, Susana Maria, additional, Capinha, Marta, additional, Agostinho, João, additional, Cardoso, Tania, additional, Rocha, Andreia, additional, Espinha, Mafalda, additional, Ivanov, Kyundyul Ivanovich, additional, Alexeeva, Dalyana Eduardovna, additional, Batalina, Marina Vadimovna, additional, Hegya, Daria Viktorovna, additional, Zvereva, Tatyana Nikolaevna, additional, Avdeev, Sergey Nikolaevich, additional, Tsareva, Natalia Anatolievna, additional, Galyavich, Albert Sarvatovich, additional, Nikolaevich, Bykov Aleksander, additional, Filippov, Evgeny Vladimirovich, additional, Yakovleva, Olga Eduardovna, additional, Pavlova, Olga Borisovna, additional, Skripkina, Elena Sergeevna, additional, Martynyuk, Tamila Vitalievna, additional, Bukatova, Irina Fedorovna, additional, Tregubova, Anna Viktorovna, additional, Platonov, Dmitry Yurievich, additional, Kolomeytseva, Tatyana Mikhaylovna, additional, Al Dalaan, Abdullah, additional, Abdelsayed, Abeer Abeer, additional, Weheba, Ihab, additional, Saleemi, Sarferaz, additional, Sakkijha, Hussam, additional, Bohacekova, Marcela, additional, Valkovicova, Tatiana, additional, Farkasova, Iveta, additional, Quezada, Carlos Andres, additional, Piccari, Lucilla, additional, Blanco, Isabel, additional, Sebastian, Laura, additional, Roman, Antonio, additional, Lopez, Manuel, additional, Otero, Remedios, additional, Elias, Teresa, additional, Jara, Luis, additional, Asencio, Isabel, additional, Arjona, Josefa Jiménez, additional, Almagro, Raúl Menor, additional, Cárdenas, Salvador López, additional, García, Salvador Alcaraz, additional, Rodríguez, Patricia Villanueva, additional, Lopez, Raquel, additional, Garcia, Alberto, additional, Avilés, Francisco Fernandez, additional, De La Pava, Sebastian, additional, Yotti, Raquel, additional, Peñate, Gregorio Pérez, additional, Marrero, Fernando León, additional, Cifrián Martínez, José Manuel, additional, Martinez-Meñaca, Amaya, additional, Alonso, Lecue Pilar, additional, Rozas, Sonia Fernandez, additional, Fernandez, David Iturbe, additional, Cuesta, Victor Mora, additional, Söderberg, Stefan, additional, Bartfay, Sven-Erik, additional, Rundqvist, Bengt, additional, Alfetlawi, Monthir, additional, Wodlin, Peter, additional, Schwarz, Esther Irene, additional, Speich, Rudolf, additional, Lador, Frédéric, additional, Rochat, Thierry, additional, Gasche-Soccal, Paola, additional, Hsu, Chih-Hsin, additional, Lin, Tsung-Hsien, additional, Su, Ho-Ming, additional, Lai, Wen-Ter, additional, Chu, Chun Yuan, additional, Hsu, Po-Chao, additional, Voon, Wen-Chol, additional, Yen, Hsueh-Wei, additional, Yih-Jer Wu, Jacob, additional, Wu, Shu-Hao, additional, Huang, Wen-Pin, additional, Fong, Man-Cai, additional, Huang, Chien-Lung, additional, Kuo, Ping-Hung, additional, Lin, Yen-Hung, additional, Lin, Jiunn-Lee, additional, Hung, Chi-Sheng, additional, Wu, Cho-Kai, additional, Sung, Shih-Hsien, additional, Huang, Wei-Chun, additional, Cheng, Chin-Chang, additional, Kuo, Shu-Hung, additional, Wang, Wen-Hwa, additional, Ho, Wan-Jing, additional, Hsu, Tsu-Shiu, additional, Mutlu, Bülent, additional, Atas, Halil, additional, Ongen, Gul, additional, Un, Zeynep, additional, Okumus, Gulfer, additional, Hanta, Ismail, additional, Corris, Paul, additional, Peacock, Andrew, additional, Church, Colin, additional, Toshner, Mark, additional, and Newnham, Michael, additional

Published
2021
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29. 2018 TSOC guideline focused update on diagnosis and treatment of pulmonary arterial hypertension

Author

Huang, Wei-Chun, primary, Hsu, Chih-Hsin, additional, Sung, Shih-Hsien, additional, Ho, Wan-Jing, additional, Chu, Chun-Yuan, additional, Chang, Chih-Ping, additional, Chiu, Yu-Wei, additional, Wu, Chun-Hsien, additional, Chang, Wei-Ting, additional, Lin, Lin, additional, Lin, Shoa-Lin, additional, Cheng, Chin-Chang, additional, Wu, Yih-Jer, additional, Wu, Shu-Hao, additional, Hsieh, Tsu-Yi, additional, Hsu, Hsao-Hsun, additional, Fu, Morgan, additional, Dai, Zen-Kong, additional, Kuo, Ping-Hung, additional, Hwang, Juey-Jen, additional, and Cheng, Shu-Meng, additional

Published
2019
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43. Long-Term Survival of Patients with Pulmonary Arterial Hypertension at a Single Center in Taiwan

Author

Wang, Le-Yung, Lee, Kuang-Tso, Lin, Chia-Pin, Hsu, Lung-An, Wang, Chun-Li, Hsu, Tsu-Shiu, and Ho, Wan-Jing

Subjects
Original Article
Abstract

Clinical studies have suggested predictive parameters in mortality risk assessment for pulmonary arterial hypertension (PAH) patients. However, these studies predominantly include Caucasian population; information in Asian population is relatively deficient. In this study, we investigated the long-term survival of PAH patients and the predictors of mortality in our population.We prospectively collected 70 patients with PAH at the Chang Gung Memorial Hospital between March 2002 and February 2015. Baseline data including functional class (FC), 6-minute walk distance (6MWD), hematological and biochemical data, echocardiography and cardiac catheterization were obtained before commencing PAH- targeted treatment. The follow-up period for analyses of survivors ended in October 2015.The mean age at diagnosis was 40.7 ± 15.2 years. Mean follow-up period was 4.6 ± 3.4 years, with 1-, 2-, 3-, and 5-year survival rates of 93%, 88%, 84%, and 77%, respectively. The baseline FC was worse in non-survivors than in survivors. More frequent presence of pericardial effusion, higher serum glucose levels, higher estimated systolic pulmonary artery pressure (SPAP) by echocardiography, and higher right atrial pressure (RAP) were found in non-survivors. Higher FC, lower 6MWD, and presence of pericardial effusion were associated with risk of mortality. Patients with worsening FC and increased serum uric acid had an increased risk of mortality during follow-up.The overall survival remained unsatisfactory in PAH patients. Baseline FC, 6MWD, pericardial effusion, RAP, and a worsening FC and an increased serum uric acid levels during follow-up were significant prognostic parameters.

Published
2017

49. 2014 Guidelines of Taiwan Society of Cardiology (TSOC) for the Management of Pulmonary Arterial Hypertension

Author

Hsu, Chih-Hsin, Ho, Wan-Jing, Huang, Wei-Chun, Chiu, Yu-Wei, Hsu, Tsu-Shiu, Kuo, Ping-Hung, Hsu, Hsao-Hsun, Chang, Jia-Kan, Cheng, Chin-Chang, Lai, Chao-Lun, Liang, Kae-Woei, Lin, Shoa-Lin, Sung, Hsao-Hsun, Tsai, Wei-Chuan, Weng, Ken-Pen, Hsieh, Kai-Sheng, Yin, Wei-Hsian, Lin, Shing-Jong, and Wang, Kuo-Yang

Subjects
Original Article
Abstract

Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic condition, defined as a mean pulmonary arterial pressure exceeding 25 mmHg at rest. According to the recent classifications, it is grouped into pulmonary arterial hypertension (PAH), heart-related, lung-related, thromboembolic, and miscellaneous PH. In the past two decades, tremendous advances have occurred in the field of PH. These include (1) development of clinical diagnostic algorithm and a monitoring strategy dedicated to PAH, (2) defining strong rationales for screening at-risk populations, (3) advent of pulmonary specific drugs which makes PAH manageable, (4) recognition of needs of having proper strategy of combining existing pulmonary specific drugs, and/or potential novel drugs, (5) pursuit of clinical trials with optimal surrogate endpoints and study durations, (6) recognition of critical roles of PH/right ventricular function, as well as interdependence of ventricles in different conditions, especially those with various phenotypes of heart failure, and (7) for rare diseases, putting equal importance on carefully designed observation studies, various registries, etc., besides double blind randomized studies. In addition, ongoing basic and clinical research has led to further understanding of relevant physiology, pathophysiology, epidemiology and genetics of PH/PAH. This guidelines from the working group of Pulmonary Hypertension of the Taiwan Society of Cardiology is to provide updated guidelines based on the most recent international guidelines as well as Taiwan's domestic research on PH. The guidelines are mainly for the management of PAH (Group 1) ; however the majority of content can be helpful for managing other types of PH.Pulmonary arterial hypertension; Taiwan guidelines.

Published
2014

50. Improvement of Right Ventricular Function in Pulmonary Arterial Hypertension with Disease-Specific Therapy - A Clinical Observational Study

Author

Ho, Wan-Jing, Lin, Chia-Pin, Wang, Chun-Li, Hsu, Lung-An, Yu, Kuang-Hui, Luo, Shue-Fen, Chen, Ji-Yih, and Hsu, Tsu-Shiu

Subjects
Original Article
Abstract

Pulmonary arterial hypertension (PAH) is a serious and progressive disorder that can result in right ventricular (RV) dysfunction and mortality. Consequently, it is important to monitor RV function during management of PAH. The aim of this study was to investigate the change in RV function by echocardiography before and after disease-specific therapy.We recruited 31 PAH patients with functional class (FC) III or IV. All the patients received a comprehensive assessment before disease-specific therapy was administered, including observation of clinical symptoms, 6-min walk distance (6MWD), serum brain natriuretic peptide (BNP) level, and transthoracic echocardiography. The assessment was repeated 12 weeks after therapy.Twenty-eight patients with a mean age of 40 years completed the study, of whom 82% were women. We found that the etiologies were mainly connective tissue disease-associated and idiopathic PAH. Of the patients in our study, 36% received endothelin receptor antagonist and 64% received phosphodiesterase-5 inhibitor. There was a significant improvement in FC after disease-specific therapy (p0.001). The 6MWD increased from 326 to 403 m (p0.001), and the serum BNP level decreased from 242 to 130 pg/mL (p = 0.008) after treatment. Echocardiography showed significant reduction in the right atrial and RV areas, pulmonary artery pressure, RV free wall thickness, and inferior vena cava diameter. The myocardial performance index and left ventricular eccentricity index were significantly reduced after therapy.For PAH patients in our study, disease-specific therapy for 12 weeks resulted in an improvement in FC, 6MWD, serum BNP levels, and RV function.Disease-specific therapy; Pulmonary arterial hypertension; Right ventricular function.

Published
2014

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