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4. A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology

Author

Lieberman, Jay A., Chu, Derek K., Ahmed, Tasnuva, Dribin, Timothy E., Abrams, Elissa M., Anagnostou, Aikaterini, Blumenthal, Kimberly G., Boguniewicz, Mark, Chase, Nicole M., Golden, David B.K., Hartog, Nicholas L., Heimall, Jennifer R., Ho, Tina, Lawrence, Monica G., Khan, David A., Minniear, Timothy Dean, Mustafa, S. Shahzad, Oppenheimer, John J., Phillips, Elizabeth J., Ramsey, Allison, Rider, Nicholas L., Schneider, Lynda, Shaker, Marcus S., Spergel, Jonathan M., Stone, Cosby A., Jr, Stukus, David R., Wang, Julie, and Greenhawt, Matthew J.

Published
2024
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7. Multicenter Study of Long-Term Outcomes and Quality of Life in PHACE Syndrome after Age 10

Author

Braun, Mitchell, Frieden, Ilona J., Siegel, Dawn H., George, Elizabeth, Hess, Christopher P., Fox, Christine K., Chamlin, Sarah L., Drolet, Beth A., Metry, Denise, Pope, Elena, Powell, Julie, Holland, Kristen, Ulschmid, Caden, Liang, Marilyn G., Barry, Kelly K., Ho, Tina, Cotter, Chantal, Baselga, Eulalia, Bosquez, David, Jain, Surabhi Neerendranath, Bui, Jordan K., Lara-Corrales, Irene, Funk, Tracy, Small, Alison, Baghoomian, Wenelia, Yan, Albert C., Treat, James R., Hogrogian, Griffin Stockton, Huang, Charles, Haggstrom, Anita, List, Mary, McCuaig, Catherine C., Barrio, Victoria, Mancini, Anthony J., Lawley, Leslie P., Grunnet-Satcher, Kerrie, Horii, Kimberly A., Newell, Brandon, Nopper, Amy, Garzon, Maria C., Scollan, Margaret E., and Mathes, Erin F.

Published
2024
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9. Use of Vaccines in Patients Receiving Dupilumab, A Systematic Review and Expert Delphi Consensus Recommendation: A position paper of the American College of Allergy, Asthma and Immunology

Author

Lieberman, Jay A, primary, Chu, Derek K, additional, Ahmed, Tasnuva, additional, Dribin, Timothy E, additional, Abrams, Elissa M, additional, Anagnostou, Aikaterini, additional, Blumenthal, Kimberly G, additional, Boguniewicz, Mark, additional, Chase, Nicole M, additional, Golden, David BK, additional, Hartog, Nicholas L, additional, Heimall, Jennifer R, additional, Ho, Tina, additional, Lawrence, Monica G, additional, Khan, David A, additional, Minniear, Timothy Dean, additional, Mustafa, S Shahzad, additional, Oppenheimer, John J, additional, Phillips, Elizabeth J, additional, Ramsey, Allison, additional, Rider, Nicholas L, additional, Schneider, Lynda, additional, Shaker, Marcus S, additional, Spergel, Jonathan M, additional, Stone, Cosby A, additional, Stukus, David R, additional, Wang, Julie, additional, and Greenhawt, Matthew J, additional

Published
2024
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10. Summertime, and the livin is easy: Winter and summer pseudoseasonal life expectancy in the United States

Author

Ho, Tina and Noymer, Andrew

Subjects
Statistics - Applications
Abstract

In temperate climates, mortality is seasonal with a winter-dominant pattern, due in part to pneumonia and influenza. Cardiac causes, which are the leading cause of death in the United States, are also winter-seasonal although it is not clear why. Interactions between circulating respiratory viruses (f.e., influenza) and cardiac conditions have been suggested as a cause of winter-dominant mortality patterns. We propose and implement a way to estimate an upper bound on mortality attributable to winter-dominant viruses like influenza. We calculate 'pseudo-seasonal' life expectancy, dividing the year into two six-month spans, one encompassing winter the other summer. During the summer when the circulation of respiratory viruses is drastically reduced, life expectancy is about one year longer. We also quantify the seasonal mortality difference in terms of seasonal "equivalent ages" (defined herein) and proportional hazards. We suggest that even if viruses cause excess winter cardiac mortality, the population-level mortality reduction of a perfect influenza vaccine would be much more modest than is often recognized.

Published
2017
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11. Vulvar Disorders

Author

Ho, Tina, primary, Habeshian, Kaiane, additional, Flood, Kelsey, additional, Nooruddin, Sameen, additional, Hollenbach, Laura, additional, Stambough, Kathryn, additional, and Marathe, Kalyani, additional

Published
2022
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13. Contributors

Author

Bender, Anna M., primary, Cohen, Bernard A., additional, Cohen, Sherry Guralnick, additional, Denny, George O., additional, Feig, Jessica L., additional, Habeshian, Kaiane Anoush, additional, Ho, Tina, additional, Kirkorian, A. Yasmine, additional, Marathe, Kalyani S., additional, Mavropoulos, John C., additional, Püttgen, Katherine Brown, additional, Rachidi, Saleh, additional, Shah, Nidhi, additional, Shyam, Nikhil, additional, and Simkin, Daren J., additional

Published
2022
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24. SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

Author

Le, Linh, primary, Escobar, Iliana E., additional, Ho, Tina, additional, Lefkovith, Ariel J., additional, Latteri, Emily, additional, Haltaufderhyde, Kirk D., additional, Dennis, Megan K., additional, Plowright, Lynn, additional, Sviderskaya, Elena V., additional, Bennett, Dorothy C., additional, Oancea, Elena, additional, and Marks, Michael S., additional

Published
2020
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32. Corrigendum to <‘A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology’> <[Annals of Allergy, Asthma & Immunology 133 (2024) 286-94]>

Author

Lieberman, Jay A., Chu, Derek K., Ahmed, Tasnuva, Dribin, Timothy E., Abrams, Elissa M., Anagnostou, Aikaterini, Blumenthal, Kimberly G., Boguniewicz, Mark, Chase, Nicole M., Golden, David B.K., Hartog, Nicholas L., Heimall, Jennifer R., Ho, Tina, Lawrence, Monica G., Khan, David A., Minniear, Timothy Dean, Mustafa, S. Shahzad, Oppenheimer, John J., Phillips, Elizabeth J., Ramsey, Allison, Rider, Nicholas L., Schneider, Lynda, Shaker, Marcus S., Spergel, Jonathan M., Stone, Cosby A., Stukus, David R., Wang, Julie, and Greenhawt, Matthew J.

Published
2024
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33. The Travel Ban Is In Effect, DOS And DHS Release FAQs To Address Concerns

Author

Ho, Tina

Subjects
United States. Department of State -- Powers and duties, United States. Department of Homeland Security -- Powers and duties, Emigration and immigration -- Political aspects -- Laws, regulations and rules, Travel restrictions -- Political aspects -- Laws, regulations and rules, Sanctions (International law) -- Interpretation and construction, Government regulation, Business, international
Abstract

On June 29, 2017, the U.S. Department of State (DOS) and the Department of Homeland Security (DHS) issued answers to frequently asked questions (FAQs) on the implementation of Executive Order [...]

Published
2017

34. Is The Travel Ban Back On? Supreme Court To Decide Its Fate Next Term

Author

Ho, Tina

Subjects
United States. Department of Homeland Security -- Powers and duties, United States. Supreme Court -- Powers and duties, International travel regulations -- Analysis, Travel restrictions -- Laws, regulations and rules, Government regulation, Business, international
Abstract

On June 26, 2017, the Supreme Court of the United States agreed to hear the appeals over the president's revised travel ban against certain foreign nationals from Iran, Libya, Somalia, [...]

Published
2017

36. Regulation of functional amyloid formation and pigmentation during melanosome biogenesis

Author

Ho, Tina and Ho, Tina

Abstract

Melanosomes are subcellular organelles specialized for the synthesis and storage of melanin pigments. Within epidermal and ocular pigment cells, melanosomes are generated from endosomal precursors in discrete stages. Early stages are characterized by the accumulation of premelanosome protein (PMEL) and its assembly into nontoxic amyloid fibrils, while later stages are characterized by the arrival of proteins important for the production of pigment. In this thesis, I will discuss two important findings relevant to melanosome biology. The first finding addresses the molecular mechanisms that regulate the transformation of PMEL from an integral membrane protein to fibrillar structures with properties of amyloid. These data show that native disulfide-bonded PMEL dimers prevent premature fibril formation early in the secretory pathway but must be resolved prior to the assembly of functional amyloid fibrils in early stage melanosomes. Failure to resolve the dimeric intermediates – as occurs with mutagenesis of a PMEL regulatory domain – decreases amyloid production in a heterologous expression system. Since the oligomerization of amyloid precursors is hardly unique, detailed characterization of the different intermediates formed by functional versus pathological amyloid proteins may bring us one step closer to understanding the mechanisms of neurodegenerative amyloid disease. The second finding addresses the localization and potential function of SLC45A2, a proton-dependent sucrose transporter encoded by the gene that is mutated in the hypopigmentary disorder oculocutaneous albinism type 4 (OCA4). While melanocytes derived from patients and mouse models of OCA4 are known to contain hypopigmented melanosomes, it is unclear why mutations in SLC45A2 lead to decreased pigment production. Our data show that SLC45A2 localizes to and functions from distinct punctate structures on/near stage III and IV melanosomes. Mislocalization of SLC45A2 leads to hypopigmentation suggesting t

Published
2015

37. Clinical course of porokeratosis ptychotropica over 7 years in an otherwise healthy child.

Author

Ho, Tina, Schwentker, Ann R., Barron, David R., and Lucky, Anne W.

Subjects
*BUTTOCKS, *THERAPEUTICS, *HISTOLOGY, *ETIOLOGY of diseases
Abstract

Porokeratosis ptychotropica is an unusual variant of porokeratosis characterized by papules and plaques located on the buttocks and gluteal cleft and showing multiple coronoid lamellae on histology. In this case report, we present the longitudinal clinical course of porokeratosis ptychotropica in a pediatric patient with individual red‐brown hyperkeratotic lesions that enlarged and became confluent prior to surgical intervention. We also discuss the etiology of porokeratosis ptychotropica and review current as well as future treatment options for the disease. [ABSTRACT FROM AUTHOR]

Published
2020
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40. The Kringle-like Domain Facilitates Post-endoplasmic ReticulumChanges to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.

Author

Ho, Tina, Watt, Brenda, Spruce, Lynn A., Seeholzer, Steven H., and Marks, Michael S.

Subjects
*ENDOPLASMIC reticulum, *OLIGOMERIZATION, *AMYLOID beta-protein, *CHEMICAL bonds, *MUTAGENESIS, *CHEMICAL species, *GEL permeation chromatography
Abstract

The formation of functional amyloid must be carefully regulated to prevent the accumulation of potentially toxic products. Premelanosome protein (PMEL) forms non-toxic functional amyloid fibrils that assemble into sheets upon which melanins ultimately are deposited within the melanosomes of pigment cells. PMEL is synthesized in the endoplasmic reticulum but forms amyloid only within post-Golgi melanosome precursors; thus, PMEL must traverse the secretory pathway in a non-amyloid form. Here, we identified two pre-amyloid PMEL intermediates that likely regulate the timing of fibril formation. Analyses by non-reducing SDS-PAGE, size exclusion chromatography, and sedimentation velocity revealed two native high Mr disulfide-bonded species that contain Golgi-modified forms of PMEL. These species correspond to disulfide bond-containing dimeric and monomeric PMEL isoforms that contain no other proteins as judged by two-dimensional PAGE of metabolically labeled/immunoprecipitated PMEL and by mass spectrometry of affinity-purified complexes. Metabolic pulse-chase analyses, small molecule inhibitor treatments, and evaluation of site-directed mutants suggest that the PMEL dimer forms around the time of endoplasmic reticulum exit and is resolved by disulfide bond rearrangement into a monomeric form within the late Golgi or a post-Golgi compartment. Mutagenesis of individual cysteine residues within the non-amyloid cysteine-rich Kringle-like domain stabilizes the disulfide-bonded dimer and impairs fibril formation as determined by electronmicroscopy. Our data show that the Kringle-like domain facilitates the resolution of disulfide-bonded PMEL dimers and promotes PMEL functional amyloid formation, thereby suggesting that PMEL dimers must be resolved tomonomers to generate functional amyloid fibrils. [ABSTRACT FROM AUTHOR]

Published
2016
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