Search

Your search keyword '"Ho, Steffan N."' showing total 140 results
Start Over Author "Ho, Steffan N."
140 results on '"Ho, Steffan N."'

1. The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Author

Cerone, Maria Antonietta, Mills, Tara C., Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N., Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, and Swanton, Charles

Published
2023
Full Text
View/download PDF

2. Phase I Results from a Study of Crizotinib in Combination with Erlotinib in Patients with Advanced Nonsquamous Non–Small Cell Lung Cancer

Author

Ou, Sai-Hong Ignatius, Govindan, Ramaswamy, Eaton, Keith D, Otterson, Gregory A, Gutierrez, Martin E, Mita, Alain C, Argiris, Athanassios, Brega, Nicoletta M, Usari, Tiziana, Tan, Weiwei, Ho, Steffan N, and Robert, Francisco

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Clinical Trials and Supportive Activities, Lung, Lung Cancer, Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adenocarcinoma, Adenocarcinoma, Bronchiolo-Alveolar, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Carcinoma, Papillary, Crizotinib, Erlotinib Hydrochloride, Female, Follow-Up Studies, Humans, Lung Neoplasms, Lymphatic Metastasis, Male, Maximum Tolerated Dose, Middle Aged, Neoplasm Staging, Prognosis, Pyrazoles, Pyridines, Survival Rate, Tissue Distribution, Erlotinib, Phase I combination trial, MET inhibitor, EGFR inhibitor, Cardiorespiratory Medicine and Haematology, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionThis phase I trial was conducted to determine the safety, maximum tolerated dose (MTD)/recommended phase II dose, and efficacy of crizotinib plus erlotinib in patients with advanced NSCLC.MethodsPatients with NSCLC and an Eastern Cooperative Oncology Group performance status of 0 to 2 after failure of one or two prior chemotherapy regimens were eligible. Erlotinib, 100 mg, was given continuously once daily starting between day -14 and -7; crizotinib, 200 mg twice daily (dose level 1) or 150 mg twice daily (dose level -1), was added continuously beginning on day 1 of treatment cycle 1. Potential pharmacokinetic interactions between crizotinib and erlotinib were evaluated.ResultsTwenty-seven patients received treatment; 26 received crizotinib plus erlotinib. Frequent adverse events were diarrhea, rash, decreased appetite, and fatigue. Dose-limiting toxicities were dehydration, diarrhea, dry eye, dysphagia, dyspepsia, esophagitis and vomiting. The MTD was crizotinib, 150 mg twice daily, with erlotinib, 100 mg once daily. Crizotinib increased the erlotinib area under the concentration-time curve 1.5-fold (dose level -1) and 1.8-fold (dose level 1). The plasma level of crizotinib appeared to be unaffected by coadministration of erlotinib. Two patients whose tumors harbored activating EGFR mutations achieved confirmed partial responses, one at each crizotinib dose level.ConclusionsThe MTD of the combination of crizotinib and erlotinib in patients with advanced NSCLC was crizotinib, 150 mg twice daily, with erlotinib, 100 mg once daily, which is less than the approved dose of either agent. The phase II portion of the study was not initiated.

Published
2017

3. Correction to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Author

Cerone, Maria Antonietta, Mills, Tara C., Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N., Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, and Swanton, Charles

Published
2023
Full Text
View/download PDF

6. Supplementary Figure 3 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., primary, Sereno, Arlene, primary, Tamraz, Susan, primary, Langley, Emma, primary, Doern, Adam, primary, Snipas, Tracey, primary, Perron, Keli, primary, Joseph, Ingrid, primary, Glaser, Scott M., primary, Ho, Steffan N., primary, Reff, Mitchell E., primary, and Hariharan, Kandasamy, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Figure 1 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., primary, Sereno, Arlene, primary, Tamraz, Susan, primary, Langley, Emma, primary, Doern, Adam, primary, Snipas, Tracey, primary, Perron, Keli, primary, Joseph, Ingrid, primary, Glaser, Scott M., primary, Ho, Steffan N., primary, Reff, Mitchell E., primary, and Hariharan, Kandasamy, primary

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 4 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., primary, Sereno, Arlene, primary, Tamraz, Susan, primary, Langley, Emma, primary, Doern, Adam, primary, Snipas, Tracey, primary, Perron, Keli, primary, Joseph, Ingrid, primary, Glaser, Scott M., primary, Ho, Steffan N., primary, Reff, Mitchell E., primary, and Hariharan, Kandasamy, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Figure 2 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., primary, Sereno, Arlene, primary, Tamraz, Susan, primary, Langley, Emma, primary, Doern, Adam, primary, Snipas, Tracey, primary, Perron, Keli, primary, Joseph, Ingrid, primary, Glaser, Scott M., primary, Ho, Steffan N., primary, Reff, Mitchell E., primary, and Hariharan, Kandasamy, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure 5 from Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., primary, Sereno, Arlene, primary, Tamraz, Susan, primary, Langley, Emma, primary, Doern, Adam, primary, Snipas, Tracey, primary, Perron, Keli, primary, Joseph, Ingrid, primary, Glaser, Scott M., primary, Ho, Steffan N., primary, Reff, Mitchell E., primary, and Hariharan, Kandasamy, primary

Published
2023
Full Text
View/download PDF

12. The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Author

Cerone, Maria Antonietta, Mills, Tara C, Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N, Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, Swanton, Charles, and consortium, SMP2

Subjects
Chemical Biology & High Throughput, Signalling & Oncogenes, Human Biology & Physiology, Ecology,Evolution & Ethology, Genome Integrity & Repair, Tumour Biology, Genetics & Genomics, Computational & Systems Biology
Abstract

Genomic screening is routinely used to guide the treatment of cancer patients in many countries. However, several multi-layered factors make this effort difficult to deliver within a clinically relevant timeframe. Here we share the learnings from the CRUK-funded Stratified Medicine Programme for advanced NSCLC patients, which could be useful to better plan future studies.

Published
2022

14. A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

Author

Bell-McGuinn, Katherine M., Matthews, Carolyn M., Ho, Steffan N., Barve, Minal, Gilbert, Lucy, Penson, Richard T., Lengyel, Ernst, Palaparthy, Rameshraja, Gilder, Kye, Vassos, Artemios, McAuliffe, William, Weymer, Sara, Barton, Jeremy, and Schilder, Russell J.

Published
2011
Full Text
View/download PDF

16. Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress

Author

Li, Song-Zhe, McDill, Bradley W., Kovach, Paul A., Ding, Li, Go, William Y., Ho, Steffan N., and Chen, Feng

Subjects
Aquaporins -- Research, Aquaporins -- Physiological aspects, Cell metabolism -- Research, Cell physiology -- Research, Physiological research, Biological sciences
Abstract

The aquaporin (AQP)2 channel mediates the reabsorption of water in renal collecting ducts in response to arginine vasopressin (AVP) and hypertonicity. Here we show that AQP2 expression is induced not only by the tonicity-responsive enhancer binding protein (TonEBP)/nuclear factor of activated T cells (NFAT)5-mediated hypertonic stress response but also by the calcium-dependent calcineurin-NFATc pathway. The induction of AQP2 expression by the calcineurin-NFATc pathway can occur in the absence of TonEBP/NFAT5. Mutational and chromatin immuno-precipitation analyses revealed the existence of functional NFAT binding sites within the proximal AQP2 promoter responsible for regulation of AQP2 by NFATc proteins and TonEBP/NFAT5. Contrary to the notion that TonEBP/NFAT5 is the only Rel/NFAT family member regulated by tonicity, we found that hypertonicity promotes the nuclear translocation of NFATc proteins for the subsequent induction of AQP2 expression. Calcineurin activity was also found to be involved in the induction of TonEBP/NFAT5 expression by hypertonicity, thus further defining the signaling mechanisms that underlie the TonEBP/NFAT5 osmotic stress response pathway. The coordinate regulation of AQP2 expression by both osmotic stress and calcium signaling appears to provide a means to integrate diverse extracellular signals into optimal cellular responses. aquaporin; nuclear factor of activated T cells; tonicity-responsive enhancer binding protein; osmotic response doi: 10.1152/ajpcell.00588.2005.

Published
2007

17. New Methods for ALK Status Diagnosis in Non–Small-Cell Lung Cancer: An Improved ALK Immunohistochemical Assay and a New, Brightfield, Dual ALK IHC–In Situ Hybridization Assay

Author

Nitta, Hiroaki, Tsuta, Koji, Yoshida, Akihiko, Ho, Steffan N., Kelly, Brian D., Murata, Lauren B., Kosmeder, Jerry, White, Katie, Ehser, Sandra, Towne, Penny, Schemp, Crystal, McElhinny, Abigail, Ranger-Moore, Jim, Bieniarz, Chris, Singh, Shalini, Tsuda, Hitoshi, and Grogan, Thomas M.

Published
2013
Full Text
View/download PDF

18. A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

Author

Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B., Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, and Glaser, Scott M.

Published
2011
Full Text
View/download PDF

20. Contributors

Author

Abrams, John M., primary, Adelman, John P., additional, Alcorn, Joseph L., additional, Alessi, Dario R., additional, Alexov, Emil, additional, Alford, Simon, additional, Alitalo, Kari, additional, Allison, James P., additional, Almo, Steven C., additional, Alory, Christelle, additional, Al-Shamkhani, Aymen, additional, Amundson, Sally A., additional, Anderson, Carl W., additional, Andersen, Jannik N., additional, Angel, Peter, additional, Appella, Ettore, additional, Arendshorst, William J., additional, Arkinstall, Steve, additional, Audhya, Anjon, additional, Avruch, Joseph, additional, Bader, Gary D., additional, Bagala, Cinzia, additional, Balch, William E., additional, Balsinde, Jesus, additional, Banerjee, Utpal, additional, Barford, David, additional, Bar-Sagi, Dafna, additional, Bartlett, Perry F., additional, Bastiaens, Philippe I.H., additional, Battelli, Chiara, additional, Baudhuin, Linnea M., additional, Beavil, Andrew J., additional, Beavil, Rebecca L., additional, Beavo, Joseph A., additional, Bello-Reuss, Elsa, additional, Bellum, Stephen, additional, Belmonte, Juan Carlos Izpisúa, additional, Bennett, Craig B., additional, Benovic, Jeffrey L., additional, Berridge, Michael J., additional, Beuning, Penny J., additional, Bhandari, Rashna, additional, Bhattacharya, Ananya, additional, Biel, Martin, additional, Bielinski, Vincent A., additional, Bilak, Hana, additional, Birnbaumer, Lutz, additional, Birrell, Geoff, additional, Bishop, Gail A., additional, Blackmer, Trillium, additional, Blackshear, Perry J., additional, Blattner, Christine, additional, Blaustein, Mordecai P., additional, Bokoch, Gary M., additional, Bonewald, Lynda F., additional, Bonomi, Marco, additional, Booden, Michelle A., additional, Boone, Charles, additional, Bootman, Martin D., additional, Bos, Johannes L., additional, Bradbury, Jane M., additional, Bradshaw, Ralph A., additional, Bresnick, Anne R., additional, Brevnova, Lena, additional, Brinkworth, Ross I., additional, Brown, Michael S., additional, Brown, Steven A., additional, Brunet, Anne, additional, Bucki, Robert, additional, Burgoyne, Robert D., additional, Buss, Janice E., additional, Butow, Ronald A., additional, Capdevila, Javier, additional, Carafoli, Ernesto, additional, Carlson, Cathrine R., additional, Carpenter, Graham, additional, Carrillo, Juan J., additional, Casey, Patrick J., additional, Catterall, William A., additional, Cerione, Richard A., additional, Cesareni, Gianni, additional, Chan, Andrew C., additional, Chang, Geoffrey, additional, Chao, Moses V., additional, Charbonneau, Harry, additional, Chen, Philip, additional, Cheng, Alan, additional, Chiu, Chris, additional, Chow, Dar-chone, additional, Chrisman, Ted D., additional, Christensen, Anne Elisabeth, additional, Chung, Jee Y., additional, Churchill, Grant C., additional, Ciechanover, Aaron, additional, Cingolani, Gino, additional, Claeysen, Sylvie, additional, Closset, Jean, additional, Cockcroft, Shamshad, additional, Cohen, Patricia T.W., additional, Cohen, Philip, additional, Colbran, Roger J., additional, Comstock, Clay E.S., additional, Conti, Marco, additional, Corbin, Jackie D., additional, Corda, Daniela, additional, Costagliola, Sabine, additional, Cote, Rick H., additional, Coughlin, Shaun R., additional, Cowart, L. Ashley, additional, Cox, Adrienne D., additional, Cragg, Mark S., additional, Crespo, José L., additional, Crosio, Claudia, additional, Daly, Christopher, additional, Damak, Sami, additional, Dasso, Mary, additional, David, Michael, additional, Davis, Anthony J., additional, Davis, Roger J., additional, Day, Richard N., additional, Degerman, Eva, additional, DeLano, Warren L., additional, Dell'Acqua, Mark L., additional, Délot, Emmanuèle, additional, Demple, Bruce, additional, Dennis, Edward A., additional, Denu, John M., additional, DePaoli-Roach, Anna A., additional, Der, Channing J., additional, de Rooij, Johan, additional, de Sauvage, Frederic, additional, Devreotes, Peter N., additional, Dewaste, Valérie, additional, Dickson, Robert B., additional, Diebold, Becky A., additional, Fiori, Pier Paolo Di, additional, Girolamo, Maria Di, additional, Diplexcito, Julie, additional, Dixon, Jack E., additional, Doms, Robert W., additional, Donoghue, Daniel J., additional, Doolittle, Russell F., additional, Døskeland, Stein Ove, additional, Dostmann, Wolfgang R.G., additional, Dreyer, Matthias K., additional, Du, Guo Guang, additional, Du, Keyong, additional, Duchen, Michael R., additional, Dunphy, William G., additional, Durgan, Joanne, additional, Dustin, Michael L., additional, Edwards, Peter A., additional, Egen, Jackson G., additional, Eiden, Lee E., additional, Elion, Elaine A., additional, Emr, Scott, additional, Engelhardt, Othmar G., additional, Erneux, Christophe, additional, Espenshade, Peter J., additional, Esplin, Edward D., additional, Evers, B. Mark, additional, Eyles, Joanne L., additional, Fame, Sheelagh, additional, Farquhar, Marilyn, additional, Feil, Robert, additional, Feng, Gui-Jie, additional, Fields, Stanley, additional, Fiordalisi, James J., additional, Firtel, Richard A., additional, Fitzgerald, Garret A., additional, Flint, Andrew, additional, Foiani, Marco, additional, Forman, Barry Marc, additional, Fornace, Albert J., additional, Francis, Sharron H., additional, Fritz, Günter, additional, Fruman, David A., additional, Galione, Antony, additional, Gandhi, Chris S., additional, Garbers, David L., additional, Garcia, K. Christopher, additional, Geiger, Benjamin, additional, Gerace, Larry, additional, Gerstner, Andrea, additional, Giaccia, Amato J., additional, Giannattasio, Michele, additional, Giguère, Vincent, additional, Glass, Christopher K., additional, Glennie, Martin J., additional, Glick, Jennifer L., additional, Goldstein, Joseph L., additional, Gopal, Venkatesh, additional, Gorospe, Myriam, additional, Govaerts, Cedric, additional, Graves, Paul R., additional, Gray, Patrick W., additional, Graziani, Irene, additional, Green, Douglas R., additional, Greenberg, Michael E., additional, Greenwald, Iva, additional, Gu, Haihua, additional, Gueven, Nuri, additional, Gutkind, J. Silvio, additional, Haeggström, Jesper Z., additional, Hall, Alan, additional, Hall, Michael N., additional, Haller, Otto, additional, Hamm, Heidi E., additional, Hannun, Yusef A., additional, Hansen, Carl A., additional, Harden, T. Kendall, additional, Hardie, D. Grahame, additional, Hasegawa, Kiminori, additional, Hawkins, Phillip T., additional, Haystead, Timothy A.J., additional, He, Xiao-lin, additional, Heizmann, Claus W., additional, Heldin, Carl-Henrik, additional, Hermiston, Michelle L., additional, Herrlich, Peter, additional, Hewat, Elizabeth A., additional, Hille, Bertil, additional, Hilton, Douglas J., additional, Hinchliffe, K.A., additional, Ho, Steffan N., additional, Ho, Su-Chin, additional, Hochstrasser, Mark, additional, Hofmann, Franz, additional, Hogue, Christopher W., additional, Hol, Wim G.J., additional, Holash, Jocelyn, additional, Holmgren, Robert A., additional, Honig, Barry, additional, Hostager, Bruce S., additional, Hubbard, Stevan R., additional, Huber, Michael, additional, Hunter, Tony, additional, Huttenlocher, Anna, additional, Hymowitz, Sarah G., additional, Ihle, James N., additional, Imler, Jean-Luc, additional, Irvine, R.F., additional, Isacoff, Ehud Y., additional, Iturrioz, Xavier, additional, Iversen, Lars F., additional, Iyengar, Ravi, additional, Jackson, Stephen P., additional, Jan, Lily Yeh, additional, Janiak-Spens, Fabiola, additional, Janmey, Paul A., additional, Jansen, Peter Gildsig, additional, Jarriault, Sophie, additional, Javitch, Jonathan A., additional, Jensen, Elwood V., additional, Jepsen, Kristen, additional, Jones, E. Yvonne, additional, Jones, Katherine A., additional, Jordan, J. Dedrick, additional, Joseph, Jomon, additional, Justement, Louis B., additional, Kafri, Yariv, additional, Kahn, Richard A., additional, Kang, Shin W., additional, Karlin, Arthur, additional, Kast-Woelbern, Heidi R., additional, Kaufman, Randal J., additional, Kazlauskas, Andrius, additional, Keen, James H., additional, Kemler, Rolf, additional, Kemp, Bruce E., additional, Kennedy, Mary B., additional, Kennedy, Matthew A., additional, Kikkawa, Ushio, additional, Kim, Albert H., additional, Kim, Soo-A, additional, Kim, Sung-Hou, additional, Kim, Youngjoo, additional, King-Jones, Kirst, additional, Kintner, Chris, additional, Kivimäe, Saul, additional, Klee, Claude B., additional, Klein, Rüdiger, additional, Kleppisch, Thomas, additional, Kliewer, Steven A., additional, Klinghoffer, Richard A., additional, Knoblich, Juergen A., additional, Kobe, Bostjan, additional, Kochs, George, additional, Kong-Beltran, Monica, additional, König, Rolf, additional, Koong, Albert C., additional, Korc, Murray, additional, Kornitzer, Daniel, additional, Kossiakoff, Anthony A., additional, Kotera, Jun, additional, Kovalenko, M.V., additional, Kozasa, Tohru, additional, Kozlov, Sergei, additional, Kozminski, Keith G., additional, Krugmann, Sonja, additional, Kuriyan, John, additional, Kurokawa, Riki, additional, Kwong, Peter D., additional, Lai, Wi S., additional, Lamar, Elise, additional, Lambert, Millard H., additional, Lambright, David G., additional, Lancet, Doron, additional, Landry, Reiko, additional, Langdon, Wallace Y., additional, Langeberg, Lorene K., additional, Lasko, Paul, additional, Latham, Vaughn, additional, Lavin, Martin F., additional, Lease, Kevin A., additional, Leffler, Hakon, additional, Lemmon, Mark A., additional, Leonard, Ann E., additional, Levitzki, Alexander, additional, Liao, Hong-Jun, additional, Liaw, Lucy, additional, Liberi, Giordano, additional, Lickert, Heiko, additional, Liddington, Robert C., additional, Lincoln, Thomas M., additional, Linder, Jürgen U., additional, Linder, Maurine E., additional, Liu, Hui, additional, Liu, Zhengchang, additional, Lohela, Marja K., additional, Louie, Sarah H., additional, Luttrell, Deirdre K., additional, Luttrell, Louis M., additional, Lyons, Karen M., additional, Macaulay, S. Lance, additional, Maceyka, Michael, additional, Maciag, Thomas, additional, Macian, Fernando, additional, MacKintosh, Carol, additional, MacLennan, David H., additional, Mahmood, Nadir A., additional, Malbon, Craig C., additional, Malik, Sohail, additional, Man, Orna, additional, Manahan, Carol L., additional, Mandinova, Anna, additional, Manganiello, Vincent C., additional, Manley, James L., additional, Mann, Matthias, additional, Manning, Gerald, additional, Manser, Ed, additional, Margeta-Mitrovic, Marta, additional, Margolskee, Robert F., additional, Marinissen, Julia, additional, Mariuzza, Roy A., additional, Marmor, Mina D., additional, Martin, G. Steven, additional, Martin, Karen H., additional, Martinez, Sergio E., additional, Mathews, Michael B., additional, Mayer, Bruce J., additional, Mayer, Mark L., additional, Mazzoni, Maria R., additional, McCormick, Frank, additional, McGowan, Clare H., additional, McKay, Melissa M., additional, McKeehan, Wallace L., additional, McLean, Alison J., additional, Means, Anthony R., additional, Meili, Ruedi, additional, Meng, Jingwei, additional, Merchant, Mark, additional, Mercurio, Frank, additional, Milligan, Graeme, additional, Ming, Guo-Li, additional, Minor, Daniel L., additional, Moghal, Nadeem, additional, Møller, Neils Peter H., additional, Mongillo, Marco, additional, Montminy, Marc, additional, Moon, Randall T., additional, Morimoto, Richard I., additional, Moss, Stephen E., additional, Mott, Helen R., additional, Mouta, Carla, additional, Muda, Marco, additional, Mumby, Marc C., additional, Murphy, Gretchen A., additional, Muzi-Falconi, Marco, additional, Nagaraj, Raghavendra, additional, Nahorski, Stefan R., additional, Nairn, Angus C., additional, Nash, Piers, additional, Neel, Benjamin G., additional, Newton, Alexandra C., additional, Nishizuka, Yasutomi, additional, Noel, Joseph P., additional, Nollen, Ellen A.A., additional, Nooren, Irene M.A., additional, O'Connor, Rodney, additional, Offermanns, Stefan, additional, Olender, Tsviya, additional, Ong, Shao-En, additional, Owen, Darerca, additional, Pagliari, Lisa J., additional, Pao, Lily, additional, Papaconstantinou, John, additional, Pardo, Leonardo, additional, Park, Hay-Oak, additional, Park, Young Chul, additional, Parker, Peter J., additional, Parsons, J. Thomas, additional, Passner, J.M., additional, Pawson, Tony, additional, Pelliccioli, Achille, additional, Perez-Polo, J. Regino, additional, Perrimon, Norbert, additional, Petite, Fabrice G., additional, Petroulakis, Emmanuel, additional, Pfaff, Samuel L., additional, Piehler, Jacob, additional, Pike, Linda J., additional, Pinkoski, Michael J., additional, Pixley, Fiona J., additional, Plevani, Paolo, additional, Poo, Mu-ming, additional, Pozzan, Tullioi, additional, Prescott, Stephen M., additional, Prudovsky, Igor, additional, Putney, James W., additional, Radimerski, Thomas, additional, Radzio-Andzelm, Elzbieta, additional, Ram, Prahlad T., additional, Rameh, Lucia, additional, Ramljak, Danica, additional, Ranscht, Barbara, additional, Rao, Anjana, additional, Raport, Carol J., additional, Reeves, Jacqueline D., additional, Rehman, Holger, additional, Reichman, Trevor W., additional, Reiter, Eric, additional, Resnick, Michael A., additional, Reth, Michael, additional, Rhee, Sue Goo, additional, Richter, Joel D., additional, Rietze, Rodney L., additional, Rini, James M., additional, Ripperger, Jürgen A., additional, Rizo, Josep, additional, Robishaw, Janet D., additional, Roderick, H. Llewelyn, additional, Roeder, Robert G., additional, Rohrschneider, Larry R., additional, Ron, David, additional, Rosenfeld, Michael G., additional, Rosenfeldt, Hans, additional, Rossman, Kent L., additional, Roth, Christopher B., additional, Rudolph, Markus G., additional, Ruppelt, Anja, additional, Saez, Lino, additional, Sakmar, Thomas P., additional, Salvesen, Guy S., additional, Sassone-Corsi, Paolo, additional, Saxe, Charles L., additional, Schäfer, Beat W., additional, Schibler, Ueli, additional, Schindler, Christian W., additional, Schmelzle, Tobias, additional, Schmid, Sandra L., additional, Schmidt, Anja, additional, Schmidt, Eric F., additional, Schreiber, Gideon, additional, Schultz, Joachim E., additional, Schwaller, Beat, additional, Schwamborn, Klaus, additional, Schwartz, Thue, additional, Schwindinger, William F., additional, Scita, Giorgio, additional, Scott, John D., additional, Scott, Shaun, additional, Seebeck, Thomas, additional, Serhan, Charles N., additional, Shabb, John B., additional, Shaw, Andrey S., additional, Shears, Stephen B., additional, Shenolikar, Shirish, additional, Shi, Lei, additional, Shin, Chanseok, additional, Shiozaki, Kazuhiro, additional, Shokat, Kevan M., additional, Shuttleworth, Trevor J., additional, Siderovski, David P., additional, Siegelbaum, Steven A., additional, Silverstein, Adam M., additional, Singer, Robert H., additional, Skinner, Michael K., additional, Slack-Davis, Jill K., additional, Smerdon, Stephen J., additional, Smith, Graeme C.M., additional, Smits, Guillaume, additional, Smolik, Sarah M., additional, Smotrys, Jessica E., additional, Smyth, Emer M., additional, Snyder, Jason T., additional, Sogame, Naoko, additional, Soldi, Raffaella, additional, Sondek, John, additional, Sonenberg, Nahum, additional, Sonneberg, Erica Dutil, additional, Sparrow, Lindsay G., additional, Spiegel, Sarah, additional, Sprang, Stephen R., additional, Srivastava, Deepak, additional, Stanfield, Robyn L., additional, Stanley, E. Richard, additional, Stauber, Deborah J., additional, Stefan, Christopher, additional, Stenson-Holst, Lena, additional, Stephens, Len, additional, Sternberg, Paul W., additional, Sternweis, Paul C., additional, Steward, Ruth, additional, Stickney, John T., additional, Stoker, Andrew W., additional, Strittmatter, Stephen M., additional, Stronach, Beth E., additional, Strong, Roland K., additional, Stroud, Robert M., additional, Südhof, Thomas C., additional, Sunahara, Roger K., additional, Sutton, Brian J., additional, Szabolcs, Sipeki, additional, Tang, Xiao-Bo, additional, Taskén, Kjetil, additional, Tatebe, Hisashi, additional, Tauszig-Delamasure, Servane, additional, Taylor, Colin W., additional, Taylor, Garry L., additional, Taylor, Laura J., additional, Taylor, Susan S., additional, Thomas, George, additional, Thomas, Robert P., additional, Thompson, E. Brad, additional, Thompson, Michael J., additional, Thornton, Janet M., additional, Thummel, Carl S., additional, Togashi, Hideaki, additional, Tong, Amy Hin Yan, additional, Tonks, Nicholas K., additional, Tontonoz, Peter, additional, Topham, M.K., additional, Torgersen, Knut Martin, additional, Tran, Hien, additional, Tremblay, Michel L., additional, Tsai, Ming-Jer, additional, Tsai, Sophia Y., additional, Tsunoda, Susan, additional, Turley, Stewart, additional, Tyson, Darren, additional, Van Etten, Robert L., additional, Vassart, Gilbert, additional, Verveer, Peter J., additional, Vlaeminck, Virginie, additional, de Vos, Abraham M., additional, Voss, Ty C., additional, Walczak, Robert, additional, Walker, Graham C., additional, Walker, John C., additional, Walter, Gernot, additional, Walter, Mark R., additional, Wang, Fen, additional, Wang, Jean Y.J., additional, Wang, Weiru, additional, Ward, Richard J., additional, Wedegaertner, Philip, additional, Wehrle, Christian, additional, Weiss, Arthur, additional, Weiss, Jamie L., additional, Wells, Alan, additional, Werner, Claudia, additional, West, Ann H., additional, Weston, Marie C., additional, Westwick, John K., additional, Wetterholm, Anders, additional, White, Morris F., additional, Whitman, Malcolm, additional, Whorton, Matt R., additional, Wiesmann, Christian, additional, Williams, Roger L., additional, Willis, William D., additional, Willson, Timothy M., additional, Wilson, Ian A., additional, Wiser, Ofer, additional, Wishart, Matthew J., additional, Wittinghofer, Alfred, additional, Woodgett, James R., additional, Worthylake, David K., additional, Wrana, Jeffrey L., additional, Wu, Hao, additional, Xiao, Yijin, additional, Xu, H. Eric, additional, Xu, Yan, additional, Xu, Zheng, additional, Yaffe, Michael B., additional, Yamada, Kenneth M., additional, Yang, Seun-Ah, additional, Yang, Wannian, additional, Yarden, Yosef, additional, Ye, Hong, additional, Ye, Weilan, additional, Yeates, Todd O., additional, Yin, Helen L., additional, York, John D., additional, Young, Edgar C., additional, Young, Kenneth W., additional, Young, Matthew A., additional, Young, Michael W., additional, Yu, Minmin, additional, Zaccai, Nathan R., additional, Zaccolo, Manuela, additional, Zamir, Eli, additional, von Zastrow, Mark, additional, Zhang, Chao, additional, Zhang, Xuewu, additional, Zhang, Zhong-Yin, additional, Zhou, Wenhong, additional, and Zoraghi, Roya, additional

Published
2003
Full Text
View/download PDF

21. Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

Author

Wolfe, Scot A., Zhou, Pei, Dotsch, Volker, Chen, Lin, You, Angie, Ho, Steffan N., Crabtree, Gerald R., Wagner, Gerhard, and Verdine, Gregory L.

Subjects
DNA binding proteins -- Analysis, Proteins -- Structure, Genetic transcription -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A 20K domain of NFATc needed to bind DNA and mobilize transcription has been identified. The two proteins use significantly different strategies for DNA recognition despite the relation between the overall folds of the NFATc DNA-binding protein and NF-kB p50. Both structures exhibit differences in the length and conformation of the segments which link these strands. NFAT and Rel proteins have been found to have a high sequence similarity.

Published
1997

22. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

Author

Timmerman, Luika A., Clipstone, Neil A., Ho, Steffan N., Northrop, Jeffrey P., and Crabtree, Gerald R.

Subjects
Calcium ions -- Observations, Genetic transcription -- Research, Cyclosporine -- Observations, FK 506 -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Sustained high concentrations of Ca2+ enable maintenance of nuclear localization of NF-AT transcription factors. The factors are involved in Ca2+ -dependent induction of genes necessary for lymphocyte activation and proliferation. However, immunosuppressive reagents, such as cyclosporin and FK506, block the subcellular localization of NF-AT family of transcription factors.

Published
1996

23. Dimeric ligands define a role for transcriptional activation domains in reinitiation

Author

Ho, Steffan N., Biggar, Stephen R., Spencer, David M., Schreiber, Stuart L., and Crabtree, Gerald R.

Subjects
Ligands -- Usage, Genetic transcription -- Regulation, Promoters (Genetics) -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Homodimeric and heterodimerizing synthetic ligands may be used as transcriptional switches to regulate the transcription, in vitro and in vivo, for both therapeutic and experimental applications. These dimers permit ligand-dependent association and disassociation of a transcriptional activation domain with a promoter. The continued presence of a transcriptional activation domain is necessary to maintain the transcription of endogenous genes in vivo, in both mammalian and yeast cells.

Published
1996

25. NF-AT components define a family of transcription factors targeted in T-cell activation

Author

Northrop, Jeffrey P., Ho, Steffan N., Chen, Lei, Thomas, Daryl J., Timmerman, Luika A., Nolan, Garry P., Admon, Arie, and Crabtree, Gerald R.

Subjects
T cells -- Research, Genetic transcription -- Regulation, Protein kinases -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

NF-AT protein complex is essential for the transcriptional expression of a group of proteins involved in immune systems. The DNA encoding NF-ATc activates the interleukin 2 (IL-2) promoter in non-T lymphocytes, indicating that NF-AT induces IL-2 gene expression. NF-AT RNA expression is confined to lymphoid tissues and is initiated by T-cell proliferations. The homologous NF-ATp protein is activated by a different signalling pathway involving intracellular Ca2+ or protein kinase C activation.

Published
1994

26. List of Contributors

Author

ALLEN, MARIE, primary, ALTING-MEES, MICHELLE A., additional, JOSÉ AYALA, FRANCISCO, additional, BÄHRING, SILVIA, additional, BANKIER, ALAN T., additional, BARRELL, BARCLAY G., additional, BAUER, STEVEN R., additional, BECK, STEPHAN, additional, BECKER-ANDRÉ, MICHAEL, additional, BEHR, JEAN-PAUL, additional, BHAGWAT, ASHOK S., additional, BHARUCHA, ADI D., additional, BIRNBOIM, H.C., additional, BOTTEMA, CYNTHIA D.K., additional, BOTTERMAN, JOHAN, additional, BRONSTEIN, IRENA, additional, BROWN, CAROL M., additional, BULL, MICHAEL, additional, CAI, ZELING, additional, CASSADY, JOSLYN D., additional, CATE, RICHARD L., additional, CHAI, KARL X., additional, CHAO, JULIE, additional, CHAO, LEE, additional, CHEE, MARK S., additional, CHEN, LIN, additional, COLECLOUGH, CHRISTOPHER, additional, CRAXTON, MOLLY, additional, DE BLOCK, MARC, additional, DE LA LUNA, SUSANA, additional, DE WET, JEFFREY R., additional, DENECKE, JÜRGEN, additional, D'HALLUIN, KATHLEEN, additional, DU, ZIJIN, additional, DUTTON, CHARYL M., additional, DWARKI, V.J., additional, EBERWINE, JAMES, additional, ECKELS, DAVID D., additional, EHRENFELS, CHRISTIAN W., additional, ERLICH, HENRY, additional, EVANS, GLEN A., additional, FERRO-LUZZI AMES, GIOVANNA, additional, FINNELL, RICHARD, additional, FROHMAN, MICHAEL A., additional, FULLER, CARL W., additional, GABRIELSEN, ODD S., additional, GARCIA, J. VICTOR, additional, GEE, MELISSA A., additional, JANE GEIGER, MARY, additional, GORSKI, JACK, additional, GUILFOYLE, TOM J., additional, GYLLENSTEN, ULF B., additional, HAGEN, GRETCHEN, additional, HANAFEY, MICHAEL K., additional, HARTL, DANIEL L., additional, HERMANSON, GARY G., additional, HO, STEFFAN N., additional, HOOD, LEROY, additional, HORTON, ROBERT M., additional, HRUBY, DENNIS E., additional, HUET, JANINE, additional, HUFFAKER, TIM C., additional, HUNT, HENRY D., additional, II, SETSUKO, additional, JANSSENS, JAN, additional, JONES, MICHAEL D., additional, JUNG, VINCENT, additional, KAWASAKI, ERNEST, additional, KREITMAN, MARTIN, additional, LANDWEBER, LAURA F., additional, LEEMANS, JAN, additional, LELONG, JEAN-CLAUDE, additional, LÉVESQUE, GEORGES, additional, LIEBER, ANDRE, additional, LOEFFLER, JEAN-PHILIPPE, additional, LUEHRSEN, KENNETH R., additional, LYNCH, CARMEL M., additional, MACFERRIN, KURTIS D., additional, MACKLER, SCOTT, additional, MAEDA, KAYO, additional, MALONE, ROBERT W., additional, MCCLURE, BRUCE A., additional, MILLER, A. DUSTY, additional, MILLER, DANIEL G., additional, MIYASHIRO, KEVIN, additional, MURPHY, OWEN J., additional, OCHMAN, HOWARD, additional, ORTÍU, JUAN, additional, PADDOCK, GARY V., additional, PADMANABHAN, R., additional, PEASE, LARRY R., additional, PESTKA, SIDNEY, additional, PESTKA, STEVEN B., additional, POTTER, HUNTINGTON, additional, POUSTKA, ANNEMARIE, additional, PULLEN, JEFFREY K., additional, RAFALSKI, J. ANTONI, additional, RAWLINSON, WILLIAM D., additional, REYNAERTS, ARLETTE, additional, RUSSELL, J.A., additional, SAIKI, RANDALL, additional, SANDIG, VOLKER, additional, SANFORD, J.C., additional, SARKAR, GOBINDA, additional, SCHEUERMANN, RICHARD H., additional, SCHREIBER, STUART L., additional, SCOTT, JAMIE K., additional, SCZAKIEL, GEORG, additional, SHORT, J.M., additional, SHYAMALA, VENKATAKRISHNA, additional, SINGH, HARINDER, additional, SMITH, F.D., additional, SMITH, GEORGE P., additional, SMITH, VICTORIA, additional, SNIDER, KEN, additional, SOH, JAEMOG, additional, SOMMER, WOLFGANG, additional, SOMMER, STEVE S., additional, SONG, YAH-RU, additional, SORGE, J.A., additional, SPENCER, CORINNE, additional, STRAUSS, MICHAEL, additional, TARTOF, KENNETH D., additional, TERRANOVA, MICHAEL P., additional, TINGEY, SCOTT V., additional, TIZARD, RICHARD, additional, VARNER, JOSEPH E., additional, VEN MURTHY, M.R., additional, VERDINE, GREGORY L., additional, VERMA, INDER M., additional, VOYTA, JOHN C., additional, WALBOT, VIRGINIA, additional, WHITTAKER, PAUL A., additional, WILLIAMS, JOHN G.K., additional, WILSON, ELIZABETH M., additional, WILSON, RICHARD K., additional, YE, ZHENG-HUA, additional, ZELENETZ, ANDREW D., additional, ZHANG, Q.X., additional, and ZHAO, L.-J., additional

Published
1995
Full Text
View/download PDF

27. Gene Splicing by Overlap Extension

Author

HORTON, ROBERT M., primary, HO, STEFFAN N., additional, PULLEN, JEFFREY K., additional, HUNT, HENRY D., additional, CAI, ZELING, additional, and PEASE, LARRY R., additional

Published
1995
Full Text
View/download PDF

31. ALK FISH positivity and crizotinib efficacy in patients (pts) with non-small cell lung cancer (NSCLC).

Author

Soria, Jean-Charles, primary, Ho, Steffan N., additional, Varella-Garcia, Marileila, additional, Iafrate, A. John, additional, Solomon, Benjamin J., additional, Shaw, Alice T., additional, Blackhall, Fiona Helen, additional, Mok, Tony, additional, Wu, Yi-Long, additional, Pestova, Ekaterina, additional, Siebert, Fred W., additional, Wilner, Keith D., additional, Polli, Anna, additional, Paolini, Jolanda, additional, Lanzalone, Silvana, additional, Green, Stephanie J., additional, and Camidge, D. Ross, additional

Published
2016
Full Text
View/download PDF

33. Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties: IMPLICATIONS FOR MECHANISM OF ACTION IN VIVOS⃞

Author

Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L., Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S., Rennard, Rachel, Graff, Christilyn P., Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N., Reff, Mitchell E., Glaser, Scott M., Dong, Jianying, Demarest, Stephen J., and Hariharan, Kandasamy

Subjects
Calorimetry, Differential Scanning, Mechanisms of Signal Transduction, Molecular Conformation, Receptors, Somatomedin, CHO Cells, Ligands, Receptor, IGF Type 1, Epitopes, Kinetics, Cricetulus, Insulin-Like Growth Factor II, Cricetinae, Animals, Humans, Allosteric Site, Epitope Mapping
Abstract

Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because of preliminary data generated in human patients with cancer. These antibodies inhibit ligand-mediated activation of IGF-1R and the resulting down-stream signaling cascade. Here we generated a panel of antibodies against IGF-1R and screened them for their ability to block the binding of both IGF-1 and IGF-2 at escalating ligand concentrations (>1 μm) to investigate allosteric versus competitive blocking mechanisms. Four distinct inhibitory classes were found as follows: 1) allosteric IGF-1 blockers, 2) allosteric IGF-2 blockers, 3) allosteric IGF-1 and IGF-2 blockers, and 4) competitive IGF-1 and IGF-2 blockers. The epitopes of representative antibodies from each of these classes were mapped using a purified IGF-1R library containing 64 mutations. Most of these antibodies bound overlapping surfaces on the cysteine-rich repeat and L2 domains. One class of allosteric IGF-1 and IGF-2 blocker was identified that bound a separate epitope on the outer surface of the FnIII-1 domain. Using various biophysical techniques, we show that the dual IGF blockers inhibit ligand binding using a spectrum of mechanisms ranging from highly allosteric to purely competitive. Binding of IGF-1 or the inhibitory antibodies was associated with conformational changes in IGF-1R, linked to the ordering of dynamic or unstructured regions of the receptor. These results suggest IGF-1R uses disorder/order within its polypeptide sequence to regulate its activity. Interestingly, the activity of representative allosteric and competitive inhibitors on H322M tumor cell growth in vitro was reflective of their individual ligand-blocking properties. Many of the antibodies in the clinic likely adopt one of the inhibitory mechanisms described here, and the outcome of future clinical studies may reveal whether a particular inhibitory mechanism leads to optimal clinical efficacy.

Published
2009

34. Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment

Author

Huang, Donghui, primary, Kim, Dong-Wan, additional, Kotsakis, Athanasios, additional, Deng, Shibing, additional, Lira, Paul, additional, Ho, Steffan N., additional, Lee, Nathan V., additional, Vizcarra, Pamela, additional, Cao, Joan Q., additional, Christensen, James G., additional, Kim, Tae Min, additional, Sun, Jong-mu, additional, Ahn, Jin Seok, additional, Ahn, Myung-Ju, additional, Park, Keunchil, additional, and Mao, Mao, additional

Published
2013
Full Text
View/download PDF

39. Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response

Author

Dong, Jianying, primary, Demarest, Stephen J., additional, Sereno, Arlene, additional, Tamraz, Susan, additional, Langley, Emma, additional, Doern, Adam, additional, Snipas, Tracey, additional, Perron, Keli, additional, Joseph, Ingrid, additional, Glaser, Scott M., additional, Ho, Steffan N., additional, Reff, Mitchell E., additional, and Hariharan, Kandasamy, additional

Published
2010
Full Text
View/download PDF

40. Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties

Author

Doern, Adam, primary, Cao, Xianjun, additional, Sereno, Arlene, additional, Reyes, Christopher L., additional, Altshuler, Angelina, additional, Huang, Flora, additional, Hession, Cathy, additional, Flavier, Albert, additional, Favis, Michael, additional, Tran, Hon, additional, Ailor, Eric, additional, Levesque, Melissa, additional, Murphy, Tracey, additional, Berquist, Lisa, additional, Tamraz, Susan, additional, Snipas, Tracey, additional, Garber, Ellen, additional, Shestowsky, William S., additional, Rennard, Rachel, additional, Graff, Christilyn P., additional, Wu, Xiufeng, additional, Snyder, William, additional, Cole, Lindsay, additional, Gregson, David, additional, Shields, Michael, additional, Ho, Steffan N., additional, Reff, Mitchell E., additional, Glaser, Scott M., additional, Dong, Jianying, additional, Demarest, Stephen J., additional, and Hariharan, Kandasamy, additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results