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2. Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin M, Baker, William L, Bosak, Kelly, Breathett, Khadijah, Fonarow, Gregg C, Heidenreich, Paul, Ho, Jennifer E, Hsich, Eileen, Ibrahim, Nasrien E, Jones, Lenette M, Khan, Sadiya S, Khazanie, Prateeti, Koelling, Todd, Krumholz, Harlan M, Khush, Kiran K, Lee, Christopher, Morris, Alanna A, Page, Robert L, Pandey, Ambarish, Piano, Mariann R, Stehlik, Josef, Stevenson, Lynne Warner, Teerlink, John R, Vaduganathan, Muthiah, Ziaeian, Boback, and Members, Writing Committee

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Humans, Heart Failure, Hospitalization, Prevalence, Incidence, Writing Committee Members, Heart failure, epidemiology, incidence, mortality, outcomes, prevalence, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2023

4. Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass

Author

Khurshid, Shaan, Lazarte, Julieta, Pirruccello, James P, Weng, Lu-Chen, Choi, Seung Hoan, Hall, Amelia W, Wang, Xin, Friedman, Samuel F, Nauffal, Victor, Biddinger, Kiran J, Aragam, Krishna G, Batra, Puneet, Ho, Jennifer E, Philippakis, Anthony A, Ellinor, Patrick T, and Lubitz, Steven A

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Genetics, Bioengineering, Rehabilitation, Heart Disease, Cardiovascular, Human Genome, Assistive Technology, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Humans, Genome-Wide Association Study, Deep Learning, Magnetic Resonance Imaging, Cine, Cardiomyopathies, Magnetic Resonance Spectroscopy, Predictive Value of Tests
Abstract

Left ventricular mass is a risk marker for cardiovascular events, and may indicate an underlying cardiomyopathy. Cardiac magnetic resonance is the gold-standard for left ventricular mass estimation, but is challenging to obtain at scale. Here, we use deep learning to enable genome-wide association study of cardiac magnetic resonance-derived left ventricular mass indexed to body surface area within 43,230 UK Biobank participants. We identify 12 genome-wide associations (1 known at TTN and 11 novel for left ventricular mass), implicating genes previously associated with cardiac contractility and cardiomyopathy. Cardiac magnetic resonance-derived indexed left ventricular mass is associated with incident dilated and hypertrophic cardiomyopathies, and implantable cardioverter-defibrillator implant. An indexed left ventricular mass polygenic risk score ≥90th percentile is also associated with incident implantable cardioverter-defibrillator implant in separate UK Biobank (hazard ratio 1.22, 95% CI 1.05-1.44) and Mass General Brigham (hazard ratio 1.75, 95% CI 1.12-2.74) samples. Here, we perform a genome-wide association study of cardiac magnetic resonance-derived indexed left ventricular mass to identify 11 novel variants and demonstrate that cardiac magnetic resonance-derived and genetically predicted indexed left ventricular mass are associated with incident cardiomyopathy.

Published
2023

8. Infertility and Risk of Heart Failure in the Women’s Health Initiative

Author

Lau, Emily S, Wang, Dongyu, Roberts, Mary, Taylor, Christy N, Murugappan, Gayathree, Shadyab, Aladdin H, Schnatz, Peter F, Farland, Leslie V, Wood, Malissa J, Scott, Nandita S, Eaton, Charles B, and Ho, Jennifer E

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Heart Disease, Infertility, Aging, Clinical Research, Cardiovascular, Prevention, Contraception/Reproduction, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Aged, Cardiovascular Diseases, Female, Heart Failure, Humans, Middle Aged, Prognosis, Risk Factors, Stroke Volume, Ventricular Function, Left, Women's Health, heart failure, infertility, women, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThere is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with future risk of heart failure (HF) is not known.ObjectivesThis study sought to examine the development of HF and HF subtypes in women with and without history of infertility.MethodsWe followed postmenopausal women from the Women's Health Initiative prospectively for the development of HF. Infertility was self-reported at study baseline. Multivariable cause-specific Cox models were used to evaluate the association of infertility with incident overall HF and HF subtypes (heart failure with preserved ejection fraction [HFpEF]: left ventricular ejection fraction of ≥50% vs heart failure with reduced ejection fraction [HFrEF]: left ventricular ejection fraction of

Published
2022

9. Association of Cardiometabolic Disease With Cancer in the Community

Author

Liu, Elizabeth E, Suthahar, Navin, Paniagua, Samantha M, Wang, Dongyu, Lau, Emily S, Li, Shawn X, Jovani, Manol, Takvorian, Katherine S, Kreger, Bernard E, Benjamin, Emelia J, Meijers, Wouter C, Bakker, Stephan JL, Kieneker, Lyanne M, Gruppen, Eke G, van der Vegt, Bert, de Bock, Geertruida H, Gansevoort, Ron T, Hussain, Shehnaz K, Hoffmann, Udo, Splansky, Greta Lee, Vasan, Ramachandran S, Larson, Martin G, Levy, Daniel, Cheng, Susan, de Boer, Rudolf A, and Ho, Jennifer E

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Lung, Nutrition, Cancer, Obesity, Prevention, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Cardiovascular, epidemiology, gastrointestinal cancer, inflammation, obesity, risk factor, BMI, body mass index, CRP, C-reactive protein, CT, computed tomographic, CVD, cardiovascular disease, HOMA-IR, homeostatic model assessment of insulin resistance, PAI, plasminogen activator inhibitor, SAT, subcutaneous adipose tissue, VAT, visceral adipose tissue, WC, waist circumference, Cardiovascular medicine and haematology, Oncology and carcinogenesis
Abstract

BackgroundObesity and cardiometabolic dysfunction have been associated with cancer risk and severity. Underlying mechanisms remain unclear.ObjectivesThe aim of this study was to examine associations of obesity and related cardiometabolic traits with incident cancer.MethodsFHS (Framingham Heart Study) and PREVEND (Prevention of Renal and Vascular End-Stage Disease) study participants without prevalent cancer were studied, examining associations of obesity, body mass index (BMI), waist circumference, visceral adipose tissue (VAT) and subcutaneous adipose tissue depots, and C-reactive protein (CRP) with future cancer in Cox models.ResultsAmong 20,667 participants (mean age 50 years, 53% women), 2,619 cancer events were observed over a median follow-up duration of 15 years. Obesity was associated with increased risk for future gastrointestinal (HR: 1.30; 95% CI: 1.05-1.60), gynecologic (HR: 1.62; 95% CI: 1.08-2.45), and breast (HR: 1.32; 95% CI: 1.05-1.66) cancer and lower risk for lung cancer (HR: 0.62; 95% CI: 0.44-0.87). Similarly, waist circumference was associated with increased risk for overall, gastrointestinal, and gynecologic but not lung cancer. VAT but not subcutaneous adipose tissue was associated with risk for overall cancer (HR: 1.22; 95% CI: 1.05-1.43), lung cancer (HR: 1.92; 95% CI: 1.01-3.66), and melanoma (HR: 1.56; 95% CI: 1.02-2.38) independent of BMI. Last, higher CRP levels were associated with higher risk for overall, colorectal, and lung cancer (P < 0.05 for all).ConclusionsObesity and abdominal adiposity are associated with future risk for specific cancers (eg, gastrointestinal, gynecologic). Although obesity was associated with lower risk for lung cancer, greater VAT and CRP were associated with higher lung cancer risk after adjusting for BMI.

Published
2022

11. HF STATS 2024: Heart Failure Epidemiology and Outcomes Statistics An Updated 2024 Report from the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin, Baker, William L., Bosak, Kelly, Breathett, Khadijah, Carter, Spencer, Drazner, Mark H., Dunlay, Shannon M., Fonarow, Gregg C., Greene, Stephen J., Heidenreich, Paul, Ho, Jennifer E., Hsich, Eileen, Ibrahim, Nasrien E., Jones, Lenette M., Khan, Sadiya S., Khazanie, Prateeti, Koelling, Todd, Lee, Christopher S., Morris, Alanna A., Page, Robert L., II, Pandey, Ambarish, Piano, Mariann R., Sandhu, Alexander T., Stehlik, Josef, Stevenson, Lynne W., Teerlink, John, Vest, Amanda R., Yancy, Clyde, and Ziaeian, Boback

Published
2024
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12. Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion

Author

HARDIN, KATHRYN M., GIVERTS, ILYA, CAMPAIN, JOSEPH, FARRELL, ROBYN, CUNNINGHAM, THOMAS, BROOKS, LIANA, CHRIST, ANASTASIA, WOOSTER, LUKE, BAILEY, COLE S., SCHOENIKE, MARK, SBARBARO, JOHN, BAGGISH, AARON, NAYOR, MATTHEW, HO, JENNIFER E., MALHOTRA, RAJEEV, SHAH, RAVI, and LEWIS, GREGORY D.

Published
2024
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14. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association

Author

Khan, Sadiya S., Coresh, Josef, Pencina, Michael J., Ndumele, Chiadi E., Rangaswami, Janani, Chow, Sheryl L., Palaniappan, Latha P., Sperling, Laurence S., Virani, Salim S., Ho, Jennifer E., Neeland, Ian J., Tuttle, Katherine R., Rajgopal Singh, Radhika, Elkind, Mitchell S.V., and Lloyd-Jones, Donald M.

Published
2023
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16. Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women

Author

Sarma, AMY A., PANIAGUA, SAMANTHA M., LAU, EMILY S., WANG, DONGYU, LIU, ELIZABETH E., LARSON, MARTIN G., HAMBURG, NAOMI M., MITCHELL, GARY F., KIZER, JORGE, PSATY, BRUCE M., ALLEN, NORRINA B., LELY, A. TITIA, GANSEVOORT, RONALD T., ROSENBERG, EMILY, MUKAMAL, KENNETH, BENJAMIN, EMELIA J., VASAN, RAMACHANDRAN S., CHENG, SUSAN, LEVY, DANIEL, BOER, RUDOLF A. DE, GOTTDIENER, JOHN S., SHAH, SANJIV J., and HO, JENNIFER E.

Published
2023
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19. Association of Initial and Longitudinal Changes in C-reactive Protein With the Risk of Cardiovascular Disease, Cancer, and Mortality

Author

Suthahar, Navin, Wang, Dongyu, Aboumsallem, Joseph Pierre, Shi, Canxia, de Wit, Sanne, Liu, Elizabeth E., Lau, Emily S., Bakker, Stephan J.L., Gansevoort, Ron.T., van der Vegt, Bert, Jovani, Manol, Kreger, Bernard E., Lee Splansky, Greta, Benjamin, Emelia J., Vasan, Ramachandran S., Larson, Martin G., Levy, Daniel, Ho, Jennifer E., and de Boer, Rudolf A.

Published
2023
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21. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association

Author

Ndumele, Chiadi E., Neeland, Ian J., Tuttle, Katherine R., Chow, Sheryl L., Mathew, Roy O., Khan, Sadiya S., Coresh, Josef, Baker-Smith, Carissa M., Carnethon, Mercedes R., Després, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, Elkind, Mitchell S.V., and Rangaswami, Janani

Published
2023
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22. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association

Author

Ndumele, Chiadi E., Rangaswami, Janani, Chow, Sheryl L., Neeland, Ian J., Tuttle, Katherine R., Khan, Sadiya S., Coresh, Josef, Mathew, Roy O., Baker-Smith, Carissa M., Carnethon, Mercedes R., Despres, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, and Elkind, Mitchell S.V.

Published
2023
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24. Abstract 17212: Arterial Cannula Size and 30-Day Mortality in Adults With Cardiogenic Shock Supported With Venoarterial Extracorporeal Membrane Oxygenation and Concomitant Left Ventricular Mechanical Unloading: An ELSO Registry Analysis

Author

Delgado, Alvaro A, Aguilar Franco, Laura, Hincapie Tabares, Daniela, Sriwattanakomen, Roy, Fleming, Lisa, Quintero Pinzon, Pablo, Ho, Jennifer E, Sabe, Marwa, Kennedy, Kevin, Garan, A. Reshad, and Grandin, E. Wilson

Published
2023
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35. Genetic analysis of right heart structure and function in 40,000 people

Author

Pirruccello, James P., Di Achille, Paolo, Nauffal, Victor, Nekoui, Mahan, Friedman, Samuel F., Klarqvist, Marcus D. R., Chaffin, Mark D., Weng, Lu-Chen, Cunningham, Jonathan W., Khurshid, Shaan, Roselli, Carolina, Lin, Honghuang, Koyama, Satoshi, Ito, Kaoru, Kamatani, Yoichiro, Komuro, Issei, Jurgens, Sean J., Benjamin, Emelia J., Batra, Puneet, Natarajan, Pradeep, Ng, Kenney, Hoffmann, Udo, Lubitz, Steven A., Ho, Jennifer E., Lindsay, Mark E., Philippakis, Anthony A., and Ellinor, Patrick T.

Published
2022
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37. Deep learning on resting electrocardiogram to identify impaired heart rate recovery

Author

Diamant, Nathaniel, Di Achille, Paolo, Weng, Lu-Chen, Lau, Emily S., Khurshid, Shaan, Friedman, Samuel, Reeder, Christopher, Singh, Pulkit, Wang, Xin, Sarma, Gopal, Ghadessi, Mercedeh, Mielke, Johanna, Elci, Eren, Kryukov, Ivan, Eilken, Hanna M., Derix, Andrea, Ellinor, Patrick T., Anderson, Christopher D., Philippakis, Anthony A., Batra, Puneet, Lubitz, Steven A., and Ho, Jennifer E.

Published
2022
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38. Cohort design and natural language processing to reduce bias in electronic health records research

Author

Khurshid, Shaan, Reeder, Christopher, Harrington, Lia X., Singh, Pulkit, Sarma, Gopal, Friedman, Samuel F., Di Achille, Paolo, Diamant, Nathaniel, Cunningham, Jonathan W., Turner, Ashby C., Lau, Emily S., Haimovich, Julian S., Al-Alusi, Mostafa A., Wang, Xin, Klarqvist, Marcus D. R., Ashburner, Jeffrey M., Diedrich, Christian, Ghadessi, Mercedeh, Mielke, Johanna, Eilken, Hanna M., McElhinney, Alice, Derix, Andrea, Atlas, Steven J., Ellinor, Patrick T., Philippakis, Anthony A., Anderson, Christopher D., Ho, Jennifer E., Batra, Puneet, and Lubitz, Steven A.

Published
2022
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39. Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics

Author

Roh, Jason D., Kitchen, Robert R., Guseh, J. Sawalla, McNeill, Jenna N., Aid, Malika, Martinot, Amanda J., Yu, Andy, Platt, Colin, Rhee, James, Weber, Brittany, Trager, Lena E., Hastings, Margaret H., Ducat, Sarah, Xia, Peng, Castro, Claire, Singh, Abhilasha, Atlason, Bjarni, Churchill, Timothy W., Di Carli, Marcelo F., Ellinor, Patrick T., Barouch, Dan H., Ho, Jennifer E., and Rosenzweig, Anthony

Published
2022
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44. Deep learning enables genetic analysis of the human thoracic aorta

Author

Pirruccello, James P., Chaffin, Mark D., Chou, Elizabeth L., Fleming, Stephen J., Lin, Honghuang, Nekoui, Mahan, Khurshid, Shaan, Friedman, Samuel F., Bick, Alexander G., Arduini, Alessandro, Weng, Lu-Chen, Choi, Seung Hoan, Akkad, Amer-Denis, Batra, Puneet, Tucker, Nathan R., Hall, Amelia W., Roselli, Carolina, Benjamin, Emelia J., Vellarikkal, Shamsudheen K., Gupta, Rajat M., Stegmann, Christian M., Juric, Dejan, Stone, James R., Vasan, Ramachandran S., Ho, Jennifer E., Hoffmann, Udo, Lubitz, Steven A., Philippakis, Anthony A., Lindsay, Mark E., and Ellinor, Patrick T.

Published
2022
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45. Predictors and outcomes of heart failure with mid‐range ejection fraction

Author

Bhambhani, Vijeta, Kizer, Jorge R, Lima, Joao AC, van der Harst, Pim, Bahrami, Hossein, Nayor, Matthew, de Filippi, Christopher R, Enserro, Danielle, Blaha, Michael J, Cushman, Mary, Wang, Thomas J, Gansevoort, Ron T, Fox, Caroline S, Gaggin, Hanna K, Kop, Willem J, Liu, Kiang, Vasan, Ramachandran S, Psaty, Bruce M, Lee, Douglas S, Brouwers, Frank P, Hillege, Hans L, Bartz, Traci M, Benjamin, Emelia J, Chan, Cheeling, Allison, Matthew, Gardin, Julius M, Januzzi, James L, Levy, Daniel, Herrington, David M, van Gilst, Wiek H, Bertoni, Alain G, Larson, Martin G, de Boer, Rudolf A, Gottdiener, John S, Shah, Sanjiv J, and Ho, Jennifer E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Cardiovascular, Clinical Research, Heart Disease, Good Health and Well Being, Aged, Cause of Death, Echocardiography, Female, Follow-Up Studies, Heart Failure, Heart Ventricles, Humans, Incidence, Male, Middle Aged, Prognosis, Prospective Studies, Risk Assessment, Stroke Volume, Survival Rate, United States, Heart failure, Risk factor, Ejection fraction, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsWhile heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid-range ejection fraction (HFmrEF) remain unclear. We sought to examine clinical and biochemical predictors of incident HFmrEF in the community.Methods and resultsWe pooled data from four community-based longitudinal cohorts, with ascertainment of new heart failure (HF) classified into HFmrEF [ejection fraction (EF) 41-49%], HFpEF (EF ≥50%), and HFrEF (EF ≤40%). Predictors of incident HF subtypes were assessed using multivariable Cox models. Among 28 820 participants free of HF followed for a median of 12 years, there were 200 new HFmrEF cases, compared with 811 HFpEF and 1048 HFrEF. Clinical predictors of HFmrEF included age, male sex, systolic blood pressure, diabetes mellitus, and prior myocardial infarction (multivariable adjusted P ≤ 0.003 for all). Biomarkers that predicted HFmrEF included natriuretic peptides, cystatin-C, and high-sensitivity troponin (P ≤ 0.0004 for all). Natriuretic peptides were stronger predictors of HFrEF [hazard ratio (HR) 2.00 per 1 standard deviation increase, 95% confidence interval (CI) 1.81-2.20] than of HFmrEF (HR 1.51, 95% CI 1.20-1.90, P = 0.01 for difference), and did not differ in their association with incident HFmrEF and HFpEF (HR 1.56, 95% CI 1.41-1.73, P = 0.68 for difference). All-cause mortality following the onset of HFmrEF was worse than that of HFpEF (50 vs. 39 events per 1000 person-years, P = 0.02), but comparable to that of HFrEF (46 events per 1000 person-years, P = 0.78).ConclusionsWe found overlap in predictors of incident HFmrEF with other HF subtypes. In contrast, mortality risk after HFmrEF was worse than HFpEF, and similar to HFrEF.

Published
2018

46. Coronary Microvascular Function Following Severe Preeclampsia

Author

Honigberg, Michael C., primary, Economy, Katherine E., additional, Pabón, Maria A., additional, Wang, Xiaowen, additional, Castro, Claire, additional, Brown, Jenifer M., additional, Divakaran, Sanjay, additional, Weber, Brittany N., additional, Barrett, Leanne, additional, Perillo, Anna, additional, Sun, Anina Y., additional, Antoine, Tajmara, additional, Farrohi, Faranak, additional, Docktor, Brenda, additional, Lau, Emily S., additional, DeFaria Yeh, Doreen, additional, Natarajan, Pradeep, additional, Sarma, Amy A., additional, Weisbrod, Robert M., additional, Hamburg, Naomi M., additional, Ho, Jennifer E., additional, Roh, Jason D., additional, Wood, Malissa J., additional, Scott, Nandita S., additional, and Di Carli, Marcelo F., additional

Published
2024
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48. Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Author

Tsao, Connie W., Aday, Aaron W., Almarzooq, Zaid I., Anderson, Cheryl A.M., Arora, Pankaj, Avery, Christy L., Baker-Smith, Carissa M., Beaton, Andrea Z., Boehme, Amelia K., Buxton, Alfred E., Commodore-Mensah, Yvonne, Elkind, Mitchell S.V., Evenson, Kelly R., Eze-Nliam, Chete, Fugar, Setri, Generoso, Giuliano, Heard, Debra G., Hiremath, Swapnil, Ho, Jennifer E., Kalani, Rizwan, Kazi, Dhruv S., Ko, Darae, Levine, Deborah A., Liu, Junxiu, Ma, Jun, Magnani, Jared W., Michos, Erin D., Mussolino, Michael E., Navaneethan, Sankar D., Parikh, Nisha I., Poudel, Remy, Rezk-Hanna, Mary, Roth, Gregory A., Shah, Nilay S., St-Onge, Marie-Pierre, Thacker, Evan L., Virani, Salim S., Voeks, Jenifer H., Wang, Nae-Yuh, Wong, Nathan D., Wong, Sally S., Yaffe, Kristine, and Martin, Seth S.

Published
2023
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