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Your search keyword '"Ho, Eliza Xin Pei"' showing total 14 results
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14 results on '"Ho, Eliza Xin Pei"'

1. Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes

Author

Ravikrishnan, Aarthi, Wijaya, Indrik, Png, Eileen, Chng, Kern Rei, Ho, Eliza Xin Pei, Ng, Amanda Hui Qi, Mohamed Naim, Ahmad Nazri, Gounot, Jean-Sebastien, Guan, Shou Ping, Hanqing, Jasinda Lee, Guan, Lihuan, Li, Chenhao, Koh, Jia Yu, de Sessions, Paola Florez, Koh, Woon-Puay, Feng, Lei, Ng, Tze Pin, Larbi, Anis, Maier, Andrea B., Kennedy, Brian K., and Nagarajan, Niranjan

Published
2024
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2. Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment.

Author

Chng, Kern Rei, Li, Chenhao, Bertrand, Denis, Ng, Amanda Hui Qi, Kwah, Junmei Samantha, Low, Hwee Meng, Tong, Chengxuan, Natrajan, Maanasa, Zhang, Michael Hongjie, Xu, Licheng, Ko, Karrie Kwan Ki, Ho, Eliza Xin Pei, Av-Shalom, Tamar V, Teo, Jeanette Woon Pei, Khor, Chiea Chuen, MetaSUB Consortium, Chen, Swaine L, Mason, Christopher E, Ng, Oon Tek, Marimuthu, Kalisvar, Ang, Brenda, and Nagarajan, Niranjan

Subjects
MetaSUB Consortium, Humans, Biofilms, Cross Infection, Opportunistic Infections, Equipment and Supplies, Hospital, Beds, Equipment Contamination, Infection Control, Disinfection, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Patients' Rooms, Singapore, Metagenomics, Tertiary Care Centers, Spatio-Temporal Analysis, Geographic Mapping, Microbiota, Medical and Health Sciences, Immunology
Abstract

Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-forming and human-microbiome-influenced environments with corresponding patterns of spatiotemporal divergence. Quasi-metagenomics with nanopore sequencing provided thousands of high-contiguity genomes, phage and plasmid sequences (>60% novel), enabling characterization of resistome and mobilome diversity and dynamic architectures in hospital environments. Phylogenetics identified multidrug-resistant strains as being widely distributed and stably colonizing across sites. Comparisons with clinical isolates indicated that such microbes can persist in hospitals for extended periods (>8 years), to opportunistically infect patients. These findings highlight the importance of characterizing antibiotic resistance reservoirs in hospitals and establish the feasibility of systematic surveys to target resources for preventing infections.

Published
2020

3. Life stage impact on the human skin ecosystem: lipids and the microbial community.

Author

Pagac, Martin P., Davient, Bala, Plado, Luca Antonio, Lam, Hilbert Yuen In, Lee, Shi Mun, Ravikrishnan, Aarthi, Chua, Wee Ling Esther, Muralidharan, Sneha, Sridharan, Aishwarya, Irudayaswamy, Antony S., Srinivas, Ramasamy, Wearne, Stephen, Mohamed Naim, Ahmad Nazri, Ho, Eliza Xin Pei, Ng, H. Q. Amanda, Kwah, Junmei Samantha, Png, Eileen, Bendt, Anne K., Wenk, Markus R., and Torta, Federico

Published
2025
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8. Species Identification and Profiling of Complex Microbial Communities Using Shotgun Illumina Sequencing of 16S rRNA Amplicon Sequences

Author

Ong, Swee Hoe, Kukkillaya, Vinutha Uppoor, Wilm, Andreas, Lay, Christophe, Ho, Eliza Xin Pei, Low, Louie, Hibberd, Martin Lloyd, and Nagarajan, Niranjan

Subjects
Quantitative Biology - Genomics
Abstract

The high throughput and cost-effectiveness afforded by short-read sequencing technologies, in principle, enable researchers to perform 16S rRNA profiling of complex microbial communities at unprecedented depth and resolution. Existing Illumina sequencing protocols are, however, limited by the fraction of the 16S rRNA gene that is interrogated and therefore limit the resolution and quality of the profiling. To address this, we present the design of a novel protocol for shotgun Illumina sequencing of the bacterial 16S rRNA gene, optimized to capture more than 90% of sequences in the Greengenes database and with nearly twice the resolution of existing protocols. Using several in silico and experimental datasets, we demonstrate that despite the presence of multiple variable and conserved regions, the resulting shotgun sequences can be used to accurately quantify the diversity of complex microbial communities. The reconstruction of a significant fraction of the 16S rRNA gene also enabled high precision (>90%) in species-level identification thereby opening up potential application of this approach for clinical microbial characterization., Comment: 17 pages, 2 tables, 2 figures, supplementary material

Published
2012
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9. Household environmental microbiota influences early‐life eczema development

Author

Ta, Le Duc Huy, primary, Tay, Carina Jing Xuan, additional, Lay, Christophe, additional, Sessions, Paola Florez, additional, Tan, Cheryl Pei Ting, additional, Tay, Michelle Jia Yu, additional, Lau, Hui Xing, additional, Zulkifli, Atiqa Binte, additional, Yap, Gaik Chin, additional, Tham, Elizabeth Huiwen, additional, Ho, Eliza Xin Pei, additional, Goh, Anne Eng Neo, additional, Godfrey, Keith M, additional, Eriksson, Johan G, additional, Knol, Jan, additional, Gluckman, Peter D, additional, Chong, Yap Seng, additional, Chan, Jerry Kok Yen, additional, Tan, Kok Hian, additional, Chong, Kok Wee, additional, Goh, Si Hui, additional, Cheng, Zai Ru, additional, Lee, Bee Wah, additional, Shek, Lynette Pei‐chi, additional, and Loo, Evelyn Xiu Ling, additional

Published
2021
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11. A pilot study to examine the association between human gut microbiota and the host's central obesity

Author

Koo, Seok Hwee, primary, Chu, Collins Wenhan, additional, Khoo, Joan Joo Ching, additional, Cheong, Magdalin, additional, Soon, Gaik Hong, additional, Ho, Eliza Xin Pei, additional, Law, Ngai Moh, additional, De Sessions, Paola Florez, additional, Fock, Kwong Ming, additional, Ang, Tiing Leong, additional, Lee, Edmund Jon Deoon, additional, and Hsiang, John Chen, additional

Published
2019
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12. Human pharyngeal microbiota in age-related macular degeneration

Author

Ho, Eliza Xin Pei, primary, Cheung, Chui Ming Gemmy, additional, Sim, Shuzhen, additional, Chu, Collins Wenhan, additional, Wilm, Andreas, additional, Lin, Clarabelle Bitong, additional, Mathur, Ranjana, additional, Wong, Doric, additional, Chan, Choi Mun, additional, Bhagarva, Mayuri, additional, Laude, Augustinus, additional, Lim, Tock Han, additional, Wong, Tien Yin, additional, Cheng, Ching Yu, additional, Davila, Sonia, additional, and Hibberd, Martin, additional

Published
2018
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13. Patient-Based Transcriptome-Wide Analysis Identify Interferon and Ubiquination Pathways as Potential Predictors of Influenza A Disease Severity

Author

Hoang, Long Truong, primary, Tolfvenstam, Thomas, additional, Ooi, Eng Eong, additional, Khor, Chiea Chuen, additional, Naim, Ahmand Nazri Mohamed, additional, Ho, Eliza Xin Pei, additional, Ong, Swee Hoe, additional, Wertheim, Heiman F., additional, Fox, Annette, additional, Van Vinh Nguyen, Chau, additional, Nghiem, Ngoc My, additional, Ha, Tuan Manh, additional, Thi Ngoc Tran, Anh, additional, Tambayah, Paul, additional, Lin, Raymond, additional, Sangsajja, Chariya, additional, Manosuthi, Weerawat, additional, Chuchottaworn, Chareon, additional, Sansayunh, Piamlarp, additional, Chotpitayasunondh, Tawee, additional, Suntarattiwong, Piyarat, additional, Chokephaibulkit, Kulkanya, additional, Puthavathana, Pilaipan, additional, de Jong, Menno D., additional, Farrar, Jeremy, additional, van Doorn, H. Rogier, additional, and Hibberd, Martin Lloyd, additional

Published
2014
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