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7. Representation of Women Authors in International Heart Failure Guidelines and Contemporary Clinical Trials

Author

Reza, Nosheen, Tahhan, Ayman Samman, Mahmud, Nadim, DeFilippis, Ersilia M, Alrohaibani, Alaaeddin, Vaduganathan, Muthiah, Greene, Stephen J, Ho, Annie Hang, Fonarow, Gregg C, Butler, Javed, O’Connor, Christopher, Fiuzat, Mona, Vardeny, Orly, Piña, Ileana L, Lindenfeld, JoAnn, and Jessup, Mariell

Subjects
Biomedical and Clinical Sciences, Medical Physiology, Cardiovascular Medicine and Haematology, Cardiovascular, Heart Disease, Clinical Research, Clinical Trials and Supportive Activities, Gender Equality, Authorship, Cardiology, Europe, Female, Humans, Manuscripts, Medical as Topic, Publishing, United States, Women, clinical trial, guideline, heart failure, publications, women, Biochemistry and Cell Biology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Medical physiology
Abstract

BackgroundGender disparities in authorship of heart failure (HF) guideline citations and clinical trials have not been examined.MethodsWe identified authors of publications referenced in Class I Recommendations in United States (n=173) and European (n=100) HF guidelines and of publications of all HF trials with >400 participants (n=118) published between 2001 and 2016. Authors' genders were determined, and changes in authorship patterns over time were evaluated with linear regression and nonparametric testing.ResultsThe median proportion of women authors per publication was 20% (interquartile range [IQR], 8%-33%) in United States guidelines, 14% (IQR, 2%-20%) in European guidelines, and 11% (IQR, 4%-20%) in HF trials. The proportion of women authors increased modestly over time in United States and European guidelines' references (β=0.005 and 0.003, respectively, from 1986 to 2016; P0.50). Overall proportions of women as first or last authors in HF trials (16%) did not change significantly over time (P=0.60). North American HF trials had the highest likelihood of having a woman as first or senior author (24%). HF trials with a woman first or senior author were associated with a higher proportion of enrolled female participants (39% versus 26%, P=0.01).ConclusionsIn HF practice guidelines and trials, few women are authors of pivotal publications. Higher number of women authors is associated with higher enrollment of women in HF trials. Barriers to authorship and representation of women in HF guidelines and HF trial leadership need to be addressed.

Published
2020

9. Why Bother with Asian American Studies? Reflections on a Documentary Research Project

Author

Sy, Cherry Lou, Ho, Annie, and Johnson, Niara

Subjects
Documentary films, College teachers, Humanities, Brooklyn College
Abstract

This document catalogs the reflections of a team of students and one faculty member who researched the history of demands for an Asian American Studies program at Brooklyn College. The authors explain their initial interests in the Asian American Studies Program project, describe their learning process as well as the research methods used. They discuss how their commitment to the project transformed during the research process, as well as their reactions to the final documentary video product, Why Is There No Asian American Studies Program at Brooklyn College. KEYWORDS student activism, Asian American Studies, Brooklyn College, student research, Cherry Lou Sy On March 16, 2021, a series of shootings that targeted Asian spas or massage parlors occurred in the metropolitan area of Atlanta, Georgia. The gunman killed eight [...]

Published
2022
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21. CIRCULATING PROGENITOR CELL COUNT: AN INDEPENDENT BIOMARKER OF ADVERSE OUTCOMES IN CORONARY ARTERY DISEASE

Author

Mehta, Anurag, primary, Meng, Qi, additional, Ahmad, Syed F., additional, Ho, Annie, additional, Desai, Shivang, additional, Dhindsa, Devinder, additional, Zuniga, Joshua, additional, Islam, Shabatun, additional, Almuwaqqat, Zakaria, additional, Nayak, Aditi, additional, Sperling, Laurence S., additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2022
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24. Vascular Regenerative Capacity and the Obesity Paradox in Coronary Artery Disease

Author

Mehta, Anurag, primary, Meng, Qi, additional, Li, Xiaona, additional, Desai, Shivang R., additional, D’Souza, Melroy S., additional, Ho, Annie H., additional, Islam, Shabatun J., additional, Dhindsa, Devinder S., additional, Almuwaqqat, Zakaria, additional, Nayak, Aditi, additional, Alkhoder, Ayman A., additional, Hooda, Ananya, additional, Varughese, Anil, additional, Ahmad, Syed F., additional, Mokhtari, Ali, additional, Hesaroieh, Iraj, additional, Sperling, Laurence S., additional, Ko, Yi-An, additional, Waller, Edmund K., additional, and Quyyumi, Arshed A., additional

Published
2021
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29. TCT-426 TAVR Versus SAVR for Bicuspid Aortic Valve

Author

Lisko, John, primary, Maidman, Samuel, additional, Kamioka, Norihiko, additional, Guyton, Robert, additional, Gleason, Patrick, additional, Alvarez, Lucia, additional, Byku, Isida, additional, Grubb, Kendra, additional, Shekiladze, Nikoloz, additional, Bakhtadze, Beka, additional, Brown, Matthew, additional, Ho, Annie, additional, Parihar, Siddhant, additional, Khan, Jaffar, additional, Devireddy, Chandan, additional, Rogers, Toby, additional, and Babaliaros, Vasilis, additional

Published
2019
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30. Simulations for Mechanical Ventilation in Children: Review and Future Prospects

Author

Flechelles, Olivier, Ho, Annie, Hernert, Patrice, Emeriaud, Guillaume, Zaglam, Nesrine, Cheriet, Farida, and Jouvet, Philippe A.

Subjects
Article Subject
Abstract

Mechanical ventilation is a very effective therapy, but with many complications. Simulators are used in many fields, including medicine, to enhance safety issues. In the intensive care unit, they are used for teaching cardiorespiratory physiology and ventilation, for testing ventilator performance, for forecasting the effect of ventilatory support, and to determine optimal ventilatory management. They are also used in research and development of clinical decision support systems (CDSSs) and explicit computerized protocols in closed loop. For all those reasons, cardiorespiratory simulators are one of the tools that help to decrease mechanical ventilation duration and complications. This paper describes the different types of simulators described in the literature for physiologic simulation and modeling of the respiratory system, including a new simulator (SimulResp), and proposes a validation process for these simulators.

Published
2013
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31. Heart to Heart : Poems

Author

Ho, Patty, Bickley, Gillian, Ho, Annie, Ho, Patty, Bickley, Gillian, and Ho, Annie

Subjects
Interpersonal relations--Poetry
Abstract

Heart to Heart: Poems by Patty Ho reveals a gentle and passionate heart longing to give and receive love and seeking to understand where love goes when life ends. The key topics and moods are Love, Loneliness, Longing and Loss. A different tone is set when she seeks to view reality from the perspective of other souls. Patty Ho has an intense interest in poetry, philosophy and music and this, her debut poetry collection, integrates treasured quotations and inspiration from famous poets, philosophers, lyricists and composers. Her poetry is stimulated by flowers, trees, stars, statues, pictures and people. Although personal relations are central to this work, history and current affairs are also subjects. Heart to Heart is stunningly illustrated with reproductions of original watercolours by the poet's sister, Annie Ho.

Published
2010

36. New season, new style.

Author

Barber, Lauren, Clark, Aimi, Cooke, Gaby, Gee, Charlotte, Ho, Annie, Lockwood, Louisa, Mosley, Caroline, Norton, Georgie, Ross, Alexis, Strang, Georgie, Taylor, Izzy, and Woods, Flo

Published
2015

37. Abstract 15473: Representation of Women Authors in Contemporary Heart Failure Clinical Trials

Author

Ho, Annie H, Samman Tahhan, Ayman, Vaduganathan, Muthiah, Greene, Stephen J, Alrohaibani, Alaaeddin, Fonarow, Gregg C, Butler, Javed, O?Connor, Christopher, Fiuzat, Mona, Pina, Ileana L, Lindenfeld, JoAnn, and Jessup, Mariell

Abstract

Introduction:Despite the important role of women in cardiovascular medicine, the disparity in women authors in heart failure (HF) clinical trials has not been addressed. We investigated the extent to which women lead publications in contemporary HF trials.Methods:We identified HF clinical trials (n=118) published between January 2001 and December 2016 using PubMed and ClinicalTrials.gov query. We determined the sex of the first, senior, and remaining authors by reviewing the first name, institutional websites and social media accounts.Results:HF clinical trials were cumulatively authored by 1488 authors (median 11, inter-quartile range (IQR), 8-15 per trial). The total number of authors increased from 9 (IQR 7-12) authors in 2001-2004 to 13 (IQR11-17) authors in 2013-2016 (P<0.001). The proportion of women authors per trial was 11% (IQR 4-20%) and remained stably low over time: 12% (IQR 0-20%) in 2001-2004 to 9% (IQR 0-20%) in 2013-2016 (P>0.50). First (90%) and senior (92%) authors were predominantly men with only 16% of publications having a woman as first or senior author, without significant change over time (P=0.60). Publications of trials conducted in North America had the highest likelihood of having a woman as first or senior author (24%) compared with multiregional (9%) and Western Europe (17%). Trials with a woman as first or senior author was associated with higher proportion of women enrolled (39% vs 26%, P=0.01). Trials authored by larger proportion of women tended to enroll higher proportions of women (R=0.39, P<0.001), Figure. The proportion of women authors was an independent predictor of women enrollment in multivariable model (P<0.0001).Conclusions:One in ten HF trial authors is a woman, and few women are first or senior authors of pivotal publications. Higher number of women authors is associated with higher enrollment of women in trials. Barriers to authorship and representation of women on HF trial leadership need to be addressed.

Published
2019
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38. Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment.

Author

Ogunmowo T, Hoffmann C, Pepper R, Wang H, Gowrisankaran S, Ho A, Raychaudhuri S, Cooper BH, Milosevic I, Milovanovic D, and Watanabe S

Abstract

Neurotransmitter is released from dedicated sites of synaptic vesicle fusion within a synapse. Following fusion, the vacated sites are replenished immediately by new vesicles for subsequent neurotransmission. These replacement vesicles are assumed to be located near release sites and used by chance. Here, we find that replacement vesicles are clustered around this region by Intersectin-1. Specifically, Intersectin-1 forms dynamic molecular condensates with Endophilin A1 near release sites and sequesters vesicles around this region. In the absence of Intersectin-1, vesicles within 20 nm of the plasma membrane are reduced, and consequently, vacated sites cannot be replenished rapidly, leading to depression of synaptic transmission. Similarly, mutations in Intersectin-1 that disrupt Endophilin A1 binding result in similar phenotypes. However, in the absence of Endophilin, this replacement pool of vesicles is available but cannot be accessed, suggesting that Endophilin A1 is needed to mobilize these vesicles. Thus, our work describes a distinct physical region within a synapse where replacement vesicles are harbored for release site replenishment.

Published
2023
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