1. Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis
- Author
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Toshlmitsu Niwa, Hldeo Yoshizumi, Naosuml Hashimoto, Yutaka Emoto, Takashl Miyazaki, Kenji Maeda, Naohfto Takeda, and Akira Tatematsu
- Subjects
medicine.medical_specialty ,Chemistry ,Anemia ,medicine.medical_treatment ,Biochemistry (medical) ,Clinical Biochemistry ,medicine.disease ,Pathogenesis ,chemistry.chemical_compound ,Immune system ,Endocrinology ,Uremic serum ,Internal medicine ,medicine ,Selected ion monitoring ,Hemodialysis ,Quantitative analysis (chemistry) ,Quinolinic acid - Abstract
Quinolinic acid was first identified in uremic serum by use of gas chromatography/mass spectrometry. Quantification by selected ion monitoring revealed that the serum concentration of quinolinic acid was markedly increased in chronic hemodialysis patients, and that the acid could be removed by conventional hemodialysis. The serum concentration of quinolinic acid was weakly but significantly correlated with the serum uric acid concentration. Accumulation of quinolinic acid in uremic blood may be involved in the pathogenesis of anemia, suppressed immune system, and uremic encephalopathy.
- Published
- 1991
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