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3. Micromachining of Parts for Microsystems

Author

Hahmann, D., Rüggeberg, M., Wittmer, R., Reichstein, M., Hlavac, M., Denkena, B., Hoffmeister, H.-W., Büttgenbach, Stephanus, editor, Burisch, Arne, editor, and Hesselbach, Jürgen, editor

Published
2011
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5. Combined inhibition of Bcl-xL/Bcl-2 and SREBP-1 results in a synergistic anti-neoplastic activity in glioblastoma cells in vitro

Author

Tosin, D, Schlotter, D, Dwucet, A, Hlavac, M, Westhoff, MA, Siegelin, MD, Wirtz, CR, and Karpel-Massler, G

Subjects
ddc: 610, Medicine and health
Abstract

Objective: A cellular homeostasis that is shifted away from apoptosis and a reprogramming of the lipid metabolism are both, features that are frequently encountered in glioblastoma. This study aimed at investigating whether a combined reprogramming of the apoptotic machinery and the lipid metabolism [for full text, please go to the a.m. URL]

Published
2022
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6. TTFields empowers the anti-glioblastoma activity of CUSP9v3 in vitro

Author

Cao, Q, Dwucet, A, Kast, R, Hlavac, M, Westhoff, MA, Siegelin, MD, Wirtz, CR, Halatsch, ME, and Karpel-Massler, G

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Drug repurposing is a promising strategy to accelerate the clinical use of therapeutics with anti-neoplastic activity. In this study, we examined whether Tumor Treating Fields (TTFields) enhance the biological effects of the repurposed CUSP9v3 regimen in an in vitro setting of glioblastoma. [for full text, please go to the a.m. URL]

Published
2022
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7. Risk factors for additional resection after intraoperative MRI in less invasive pituitary adenomas Knosp 0-2

Author

Hlavac, M, Knoll, A, Etzrodt-Walter, G, Coburger, J, Wirtz, CR, and Pala, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: We anticipated that the introduction of endoscopic technique in pituitary surgery might render our standard procedure of performing intraoperative magnetic resonance imaging (iMRI) in pituitary adenoma surgery in cases of non-invasive tumors (Knosp 0-2) redundant. Methods: We conducted[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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13. Combined treatment with ABT-263 and vacquinol exhibits synergistic anti-glioblastoma activity in vitro which can be further enhanced by inhibition of autophagy

Author

Anthonymuthu, J, Golla, C, Dwucet, A, Pruss, M, Hlavac, M, Kast, RE, Wirtz, CR, Halatsch, ME, Siegelin, MD, Westhoff, MA, and Karpel-Massler, G

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Vacquinol represents an experimental anti-malaria drug which has been previously described to provide anti-glioma activity.The purpose of this study was to examine whether treatment with vacquinol would enhance the pro-apoptotic reprogramming of glioblastoma cells following selective Bcl-2/Bcl-xL[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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15. Continuous positive airway pressure treatment, glycemia, and diabetes risk in obstructive sleep apnea and comorbid cardiovascular disease

Author

Loffler, KA, Heeley, E, Freed, R, Meng, R, Bittencourt, LR, Gonzaga Carvalho, CC, Chen, R, Hlavac, M, Liu, Z, Lorenzi-Filho, G, Luo, Y, McArdle, N, Mukherjee, S, Yap, HS, Zhang, X, Palmer, LJ, Anderson, CS, Doug Mcevoy, R, Drager, LF, Loffler, KA, Heeley, E, Freed, R, Meng, R, Bittencourt, LR, Gonzaga Carvalho, CC, Chen, R, Hlavac, M, Liu, Z, Lorenzi-Filho, G, Luo, Y, McArdle, N, Mukherjee, S, Yap, HS, Zhang, X, Palmer, LJ, Anderson, CS, Doug Mcevoy, R, and Drager, LF

Abstract

OBJECTIVE Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA. RESEARCH DESIGN AND METHODS Blood, medical history, and personal data were collected in a substudy of 888 participants in the Sleep Apnea cardioVascular Endpoints (SAVE) trial in which patients with OSA and stable CVD were randomized to receive CPAP plus usual care, or usual care alone. Serum glucose and glycated hemoglobin A1c (HbA1c)weremeasuredat baseline, 6 months, and 2 and 4 years and incident diabetes diagnoses recorded. RESULTS Median follow-up was 4.3 years. In those with preexisting diabetes (n 5 274), there was no significant difference between the CPAP and usual care groups in serum glucose, HbA1c, or antidiabetic medications during follow-up. There were also no significant between-group differences in participants with prediabetes (n 5 452) or new diagnoses of diabetes. Interaction testing suggested that women with diabetes did poorly in the usual care group, while their counterparts on CPAP therapy remained stable. CONCLUSIONS Among patients with established CVD and OSA, we found no evidence that CPAP therapy over several years affects glycemic control in those with diabetes or prediabetes or diabetes risk over standard-of-care treatment. The potential differential effect according to sex deserves further investigation.

Published
2020

16. Bcl-2/Bcl-xL inhibition enhances the anti-neoplastic activity of photodynamic therapy with 5-aminolevulinic acid against glioblastoma cells in vitro

Author

Golla, C, Anthonymuthu, J, Dwucet, A, Pruss, M, Bader, N, Hlavac, M, Siegelin, MD, Westhoff, MA, Heiland, T, Kast, RE, Wirtz, CR, Capanni, F, Halatsch, ME, Karpel-Massler, G, Golla, C, Anthonymuthu, J, Dwucet, A, Pruss, M, Bader, N, Hlavac, M, Siegelin, MD, Westhoff, MA, Heiland, T, Kast, RE, Wirtz, CR, Capanni, F, Halatsch, ME, and Karpel-Massler, G

Published
2020

21. Metabolic reprogramming following a combined treatment with imipridones and 2-deoxyglucose elicits energy depletion and synergistic anti-glioblastoma activity

Author

Pruss, M, Dwucet, A, Westhoff, MA, Hlavac, M, Siegelin, MD, Wirtz, CR, Halatsch, ME, and Karpel-Massler, G

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The purpose of this study was to examine whether dual reprogramming of the metabolome of glioblastoma cells by imipridone-mediated OXPHOS inhibition and 2-deoxyglucose-mediated inhibition of glycolysis leads to enhanced anti-cancer activity. Methods: Preclinical drug testing including[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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22. Augmented reality (AR) guided ventricular puncture – design, implementation and initial evaluation

Author

Schneider, M, Kunz, C, Zenth, D, Wirtz, CR, Pala, A, and Hlavac, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Augmented reality (AR) is a technique that superimposes virtual information into the real world. This can be achieved using AR glasses. Although being a routine procedure, ventricular drainages are only placed optimally in 60% of cases. Commercially available AR glasses are used as the[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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23. The benefit of an ultra-early postoperative MRI in low grade glioma surgery

Author

Pala, A, Hlavac, M, König, R, Wirtz, CR, and Coburger, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Decision of adjuvant treatment in low grade glioma (LGG) is often based on the presence of residual tumor after surgery. However, differentiation of tumor remnants and surgically induced artifacts can be challenging. MRI imaging immediately after surgical resection might be more appropriate[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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24. The Effects of Long-term CPAP on Weight Change in Patients With Comorbid OSA and Cardiovascular Disease: Data From the SAVE Trial

Author

Ou, Q, Chen, B, Loffler, KA, Luo, Y, Zhang, X, Chen, R, Wang, Q, Drager, LF, Lorenzi-Filho, G, Hlavac, M, McArdle, N, Mukherjee, S, Mediano, O, Barbe, F, Anderson, CS, McEvoy, RD, Woodman, RJ, Ou, Q, Chen, B, Loffler, KA, Luo, Y, Zhang, X, Chen, R, Wang, Q, Drager, LF, Lorenzi-Filho, G, Hlavac, M, McArdle, N, Mukherjee, S, Mediano, O, Barbe, F, Anderson, CS, McEvoy, RD, and Woodman, RJ

Abstract

Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [–0.40 to 0.54]; P =.773) or female subjects (mean [95% CI] between-group difference, –0.14 kg [–0.37 to 0.09]; P =.233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P =.031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change. Trial Registry: ClinicalTrials.gov; No.: NCT00738179; URL: www.clinicaltrials.gov.

Published
2019

25. Effect of obstructive sleep apnea treatment on renal function in patients with cardiovascular disease.

Author

Naughton M.T., Thien F., Young A., Grunstein R.R., Palmer L.J., Woodman R.J., Hanly P.J., McEvoy R.D., Freed R., Anderson C.S., Brockway B., Corbett A., Chang C.L., Douglas J.A., Ferrier K., Graham N., Hamilton G.S., Hlavac M., McArdle N., McLachlan J., Mukherjee S., Loffler K.A., Heeley E., Naughton M.T., Thien F., Young A., Grunstein R.R., Palmer L.J., Woodman R.J., Hanly P.J., McEvoy R.D., Freed R., Anderson C.S., Brockway B., Corbett A., Chang C.L., Douglas J.A., Ferrier K., Graham N., Hamilton G.S., Hlavac M., McArdle N., McLachlan J., Mukherjee S., Loffler K.A., and Heeley E.

Abstract

Rationale: Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. Objective(s): To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular disease. Method(s): This was a substudy of the international SAVE (Sleep Apnea Cardiovascular Endpoints) trial, in which 2,717 patients with moderate to severe OSA and established coronary or cerebrovascular disease were randomized to receive either CPAP plus usual care or usual care alone. Renal function and adverse renal events were compared between the CPAP (n = 102) and usual care (n = 98) groups. Glomerular filtration rate was estimated at randomization and at the end of follow-up, and the urinary albumin-to-creatinine ratio was measured at study exit. Measurements and Main Results: In 200 substudy participants (mean age, 64 yr; median, 4% oxygen desaturation index; 20 events/h; mean estimated glomerular filtration rate at baseline, 82 ml/min/ 1.73 m2), the median (interquartile range) changes in estimated glomerular filtration rate (ml/min/1.73 m2/yr) were 21.64 (23.45 to 20.740) in the CPAP group and 22.30 (24.53 to 20.71) in the usual care group (P = 0.21) after a median of 4.4 years. There were no between-group differences in end-of-study urinary albumin-to-creatinine ratio or in the occurrence of serious renal or urinary adverse events during the trial. The level of CPAP adherence did not influence the findings. Conclusion(s): CPAP treatment of OSA in patients with cardiovascular disease does not alter renal function or the occurrence of renal adverse events.Copyright © 2017 by the American Thoracic Society.

Published
2019

27. The role of surgery in the treatment of recurrent glioblastoma

Author

Pala, A, Schmitz, L, Knoll, A, Hlavac, M, König, R, Wirtz, CR, and Coburger, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Treatment decisions for recurrent glioblastoma (rGB) remain challenging. Individualized treatment options include surgery, various chemotherapeutic regimens and irradiation and are individually recommended by local multidisciplinary oncological teams. We have compared patients with rGB treated[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018
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32. An old psychiatric drug, olanzapine, provides antineoplastic activity against glioblastoma cells when applied as a single-agent or in combination with temozolomide

Author

Karpel-Massler, G, Kast, RE, Westhoff, MA, Dwucet, A, Welscher, N, Nonnenmacher, L, Hlavac, M, Siegelin, MD, Wirtz, CR, Debatin, KM, and Halatsch, ME

Subjects
ddc: 610, Olanzapine, 610 Medical sciences, Medicine, Glioblastoma, Repurposing
Abstract

Objective: The continuously poor prognosis of patients with glioblastoma urges the discovery of more effective therapeutics. Repurposing of already existing drugs involves the clinical application of old agents with previously not known or not utilized anti-cancer activity and represents a strategy [for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015
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36. Navigated high frequency ultrasound as an intraoperative resection control in brain tumor surgery

Author

Coburger, J, König, R, Pedro, MT, Oberhoffer, J, Hlavac, M, and Wirtz, CR

Subjects
high frequency ultrasound, intraoperative imaging, ddc: 610, glioma, 610 Medical sciences, Medicine
Abstract

Objective: Image-guided resection of intracranial lesions has become well established in most neurosurgical centers. Intraoperative MRI (ioMRI) and conventional low frequency intraoperative ultrasound (lfioUS) are the most commonly used intraoperative imaging modalities. The impact of high-frequency[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2013
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37. Use of intraoperative high-field magnetic resonance imaging in pediatric neurosurgery

Author

Mendo-Torres, J.M., König, R., Wirtz, C.R., Hlavac, M., and Schmidt, T.S.

Subjects
ddc: 610, magnetic resonance imaging, intraoperative, 610 Medical sciences, Medicine, kernspintomographie, intraoperative MRI, pediatric neurosurgery, kinderneurochirurgie
Abstract

Objective: Intraoperative MRI (iMRI) and neuronavigation are established adjuncts to the treatment of various neurosurgical disorders. In no patient population has the extent of the surgical resection been shown to be more important than in pediatric patients. Intuitively the benefits of iMRI appear[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012

38. Outcome after surgical treatment of recurrent glioblastoma multiforme with intraoperative high-field magnetic resonance imaging

Author

Hlavac, M, König, R, Schmidt, T, Seitz, K, Engelke, J, and Wirtz, CR

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Despite multimodal treatment recurrent tumor growth in glioblastoma multiforme occurs regularly. Repeated surgery seems often the best treatment but despite additional therapy, the prognosis remains poor. The repeated surgery is more demanding, because brain tissue properties are altered [for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Published
2011
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40. Comparison of incidence of adverse events in microsurgical lumbar discectomy in elective versus emergency setting

Author

Hlavac, M., Kiening, K., Wirtz, R., Haux, D., and Unterberg, A.

Subjects
musculoskeletal diseases, ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: In patients with lumbar disc herniation and pronounced neurological deficit rapid decompression of the nerve root is indicated. In the daily routine of many neurosurgical departments this is often performed at night. Critics of this practice often point out a supposed worse outcome of such[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien

Published
2009

47. Infrared marker tracking with the HoloLens for neurosurgical interventions

Author

Kunz Christian, Maurer Paulina, Kees Fabian, Henrich Pit, Marzi Christian, Hlaváč Michal, Schneider Max, and Mathis-Ullrich Franziska

Subjects
augmented reality, computer assisted surgery, ir-marker, navigation, tracking, Medicine
Abstract

Patient tracking is an essential part in a surgical augmented reality system for correct hologram to patient registration. Augmented reality can support a surgeon with visual assistance to navigate more precisely during neurosurgical interventions. In this work, a system for patient tracking based on infrared markers is proposed. These markers are widely used in medical applications and meet the special medical requirements such as sterilizability. A tracking accuracy of 0.76 mm is achieved when using the near field reflectivity and depth sensor of the HoloLens. On the HoloLens a performance of 55–60 fps is reached, which grants a sufficiently stable placement of the holograms in the operating room.

Published
2020
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